EX-10.22



 Exhibit 10.22 

AGREEMENT 
 THIS
AGREEMENT (this “Agreement”) is entered into as of March 16, 2018, by and among VX3 (DE) LP, a Delaware limited partnership (“VX3”), VX 3 Inc., an Ontario corporation (“VX GP”), Vaccinex,
Inc., a Delaware corporation (“Vaccinex”), and each of the other parties listed on the signature pages hereto (each, a “VX LP”). Each of the foregoing is referred to herein, individually, as a
“Party” and, collectively, as the “Parties.” 
 WHEREAS, VX GP is the general partner of VX3 and
the VX LPs constitute all of the limited partners of VX3; 
 WHEREAS, VX3 has entered into a license agreement and services agreement
with Vaccinex pursuant to which Vaccinex has granted a license under certain patents to use, make, have made, sell, offer and import its lead product candidate VX15 for the treatment of Huntington’s disease in the U.S. and Canada and VX3 has
engaged Vaccinex to perform certain development services for VX15; and 
 WHEREAS, subject to the terms hereof, the Parties propose
to enter into an agreement to exchange all of the limited partnership interests in VX3 for shares of common stock of Vaccinex (the “Exchange Agreement”). 

NOW, THEREFORE, in consideration of the foregoing and other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, each Party, intending legally to be bound hereby, agrees as follows: 
  

	1.	Immediately prior to the consummation of an initial public offering on Form S-1 (an “IPO”) by Vaccinex, such Party will enter into the Exchange Agreement in
substantially the form attached hereto as Exhibit A. 

  

	2.	In connection with the execution of the Exchange Agreement and an “Exchange” (as defined therein), the Parties shall take such actions and execute such documents and instruments as are reasonably necessary to
terminate and wind-down the activities of VX3, including, without limitation, the termination of the license agreement and services agreement described above or the merger of VX3 and Vaccinex, and to effect the Exchange, as applicable, including
such actions as may be reasonably requested by Vaccinex. 

  

	3.	In furtherance of the foregoing, each VX LP hereby irrevocably makes, constitutes, appoints and empowers VX GP, and the President, any Vice President and the Treasurer of VX GP, and any successor of VX GP as general
partner of VX3, acting singly or jointly, in each case with full power of substitution, such VX LP’s true and lawful agent and attorney-in-fact, with full power and
authority in such VX LP’s name, place and stead and for such VX LP’s use and benefit, to make, execute, verify, consent to, acknowledge, swear to, make oath as to, publish, file and/or record all instruments and documents, and to take all
such actions, necessary or advisable in connection with carrying out the intention and purposes and terms of this Agreement, including, without limitation, executing, acknowledging, swearing to, filing and/or recording the Exchange Agreement in
substantially the form attached hereto as 









	 	
Exhibit A. The execution and delivery by said attorney-in-fact of any such agreements, amendments, consents,
certificates, or other instruments, including the Exchange Agreement in substantially the form attached hereto as Exhibit A, shall be conclusive evidence that such execution and delivery was authorized hereby. No person designated as an attorney-in-fact in this Section 3 shall take any action as an attorney-in-fact for any VX
LP which would in any way (i) increase the liability of the VX LP beyond the liability expressly set forth in this Agreement, (ii) reduce the voting interest of the VX LP, or (iii) be adverse to the interests of the VX LP, in each
case, without the prior written consent of such VX LP. The foregoing appointment by each VX LP of VX GP as attorney-in-fact shall be deemed to be a special power of
attorney coupled with an interest in recognition of the fact that each VX LP under this Agreement will be relying upon the power of VX GP to act pursuant to this power of attorney for the orderly administration of the affairs of the LP. The
foregoing power of attorney is irrevocable and shall survive the death or disability of any VX LP who is an individual or (in the case of any VX LP which is not an individual) the dissolution, liquidation, or termination of each VX LP, and the
assignment by any VX LP of the whole or any part of such VX LP’s interest in the LP. 

  

	4.	This Agreement shall be governed by the laws of the State of Delaware, without regard to its conflicts of laws principles. 

  

	5.	This Agreement may be executed in counterparts, each of which shall be enforceable against the Parties actually executing such counterparts, and all of which shall constitute one instrument, and facsimile or .pdf
signatures shall be treated as originals for all purposes. 

 [signature pages follow] 







 
			
	VX3 (DE) LP
	
	By: VX 3 Inc., its General Partner
		
	By:	 	 /s/ Richard Sutin

	Name:	 	Richard Sutin
	Title:	 	President
	
	VX GP:
	
	VX3 INC.
		
	By:	 	 /s/ Richard Sutin

	Name:	 	Richard Sutin
	Title:	 	President
	
	VACCINEX, INC.
		
	By:	 	 /s/ Maurice Zauderer, Ph.D.

	Name:	 	Maurice Zauderer, Ph.D.
	Title:	 	CEO
	
	VX LPs:
	
	FCMI PARENT CO.
		
	By:	 	 /s/ Dan Scheiner

	Name:	 	Dan Scheiner
	Title:	 	Vice President
	
	 /s/ Richard Sutin

	 Richard Sutin

	
	 /s/ Benjamin Zarnett

	 Benjamin Zarnett



 [Signature Page to Agreement] 







 
	
	 /s/ Joseph Rutman

	 Joseph Rutman, as bare trustee for:
 Jonathan
Rutman
 Shawna Rutman Iankelevic
 Gerald Ruthman

Joseph Rutman
 Laila Rutman Alter

Reena Rutman Lauterpacht

	
	 /s/ Stephen Halperin

	Stephen Halperin
	
	 /s/ Lawrence Chernin

	Lawrence Chernin
	
	 /s/ Jack Frieberg

	Jack Frieberg


 [Signature Page to Agreement] 







 Exhibit A 

Exchange Agreement 

(attached) 







 EXECUTION VERSION 

VX3 EXCHANGE AGREEMENT 
 THIS
VX3 EXCHANGE AGREEMENT (this “Agreement”) is entered into as of March     , 2018, by and among: 
  

	(1)	VX 3 INC., an Ontario corporation (“VX GP”); 

  

	(2)	VX3 (DE) LP, a Delaware limited partnership (“LP”); 

  

	(3)	VACCINEX, INC., a Delaware corporation (“Vaccinex”); 

  

	(4)	FCMI PARENT CO., a Nova Scotia Unlimited Liability Company (“FCMI”); and 

  

	(5)	Certain investors listed on Schedule A attached hereto to whom LP issued units of limited partnership interest (the “Units”) (the “Investors”) 


Each of the above are referred to herein individually, as a “Party,” and collectively, as the “Parties.” 

WHEREAS, VX GP is the general partner of LP; 

AND WHEREAS, LP issued Units to the Investors; 

AND WHEREAS, as of the date hereof, the Investors set forth on Schedule A are all the limited partners of LP (the “Limited
Partners”); 
 AND WHEREAS, the number of Units held by the Limited Partners and the aggregate number of Units issued and
outstanding, in each case, as of the date hereof, are set forth on Schedule A; 
 AND WHEREAS, VX GP is entering into this agreement on
behalf of the Limited Partners. 
 NOW THEREFORE THIS AGREEMENT WITNESSETH that in consideration of the mutual covenants
and agreements herein contained and other good and valuable consideration, the Parties hereby agree as follows: 
  

	1	As used herein, the following terms have the following meanings: 


“Exchange” means the transfer by an Investor to Vaccinex of the number of Units in exchange for a number of Vaccinex
Shares calculated pursuant to the Exchange Ratio. As of the date hereof, the Investors hold an aggregate of [20,000,000]1 Units which are exchangeable hereunder for an aggregate of [up to
10,989,997] Vaccinex Shares. 
 “Exchange Notice” means a notice, in substantially the form of Schedule B
attached hereto, provided by or on behalf of an Investor to exercise such Investor’s Exchange Right. 
 “Exchange
Ratio” means 0.5495 Vaccinex Shares for every 1 Unit transferred pursuant to an Exchange (subject to appropriate adjustment in the event of any splits, dividends, combinations, subdivisions, recapitalizations or the like, affecting the
Units or Vaccinex Shares, in each case, 
  

	1 	To be updated as necessary as of the date of this Agreement. 








 
following the date hereof, provided, however, that no such adjustment shall be made to effect any such event affecting the Vaccinex Shares to the extent that a corresponding
adjustment is made to all issued and outstanding Units prior to such Exchange under the terms of the LPA). 
 “Exchange
Right” means the right of the Investors, FCMI and Vaccinex hereunder to initiate an Exchange. 
 “LPA” means the
Agreement of Limited Partnership of LP, dated October 27, 2017, by and among VX GP, the Investors, and any other persons who shall in the future execute and deliver the LPA as additional Limited Partners. 

“Vaccinex Shares” means shares of authorized common stock, par value $0.0001 per share, of Vaccinex. 

 

	2	In the event of a request of an Investor made to Vaccinex to exercise such Investor’s Exchange Right in respect of all but not less than all of that Investor’s Units (“Exchange Units”):


  

	 	(a)	Such Investor will transfer to Vaccinex the Exchange Units, or such transfer may be effected by VX GP, pursuant to the power of attorney granted by such Investor to VX GP as general partner of LP under the LPA;


  

	 	(b)	Vaccinex will issue to such Investor the number of Vaccinex Shares as determined by the Exchange Ratio (and as listed in Schedule A) in exchange for such Exchange Units. 


The right of Investors to exercise an Exchange Right is expressly limited to those Units held by the Investors as of the date hereof (subject
to appropriate adjustment in the event of any splits, dividends, combinations, subdivisions, recapitalizations or the like, affecting the Units following the date hereof), which Units are set forth on Schedule A to the LPA as of the date hereof.

  

	3	Without limiting Section 2, in the event of a request of FCMI made to Vaccinex to exercise FCMI’s Exchange Right in respect of all but not less than all of FCMI’s Units: 


 

	 	(a)	Each Investor, including FCMI, will transfer to Vaccinex all but not less than all of that Investor’s Units, or such transfer may be effected by VX GP, pursuant to the power of attorney granted by such Investor to
VX GP as general partner of LP under the LPA; 

  

	 	(b)	Vaccinex will issue to each Investor, including FCMI, the number of Vaccinex Shares as determined by the Exchange Ratio in exchange for such Investor’s Units. 


 

	4	Vaccinex may exercise the Exchange Right at its option, at any time, so as to result in the transfer of all but not less than all of the then-outstanding Units to Vaccinex in any of the following circumstances:


  

	 	(a)	Vaccinex has entered into (including by entering into definitive documents related thereto) a transaction such as a sale, merger or consolidation such that Vaccinex Shares are or will be sold or, exchanged for cash
and/or marketable securities; 


  
 2 









	 	(b)	At any time on or after the fifth anniversary of the date hereof; and 

  

	 	(c)	Vaccinex or LP has entered into (including by entering into definitive documents related thereto) a licensing, partnering or similar transaction, including a product sale or option to enter into the foregoing, with
respect to one or more of the products and indications licensed to LP by Vaccinex, and all amounts then due and owing to LP in connection with such transaction have been paid to LP; provided, that Vaccinex will use its commercially reasonable
efforts to structure the transaction, or enter into such related transactions, such that the Investors are either able to defer tax liabilities, to the extent permitted by law, or to monetize a portion of their Units or Vaccinex Shares so as to
defray any taxes arising as a result of the transaction, in each case, in accordance with applicable law. 

 For the avoidance
of doubt, (i) following the consummation of an Exchange in accordance with this Agreement with respect to all Units, other than as a holder of Vaccinex Shares, if applicable, neither LP nor the Investors shall have a right to receive proceeds
of such transaction paid to Vaccinex or LP following the consummation of such Exchange, and (ii) the Parties agree and acknowledge that nothing contained in this Agreement shall require Vaccinex or LP to obtain the consent of any Party hereto
in order to enter into or consummate any such transaction. 
  

	5	In the event either an Investor, FCMI or Vaccinex exercise their Exchange Right hereunder, each Investor, FCMI and Vaccinex shall take all steps necessary to effect the applicable Exchange on the terms and conditions
contained herein, including by taking any action reasonably requested by Vaccinex with respect to the transfer of Units. 

  

	6	Vaccinex Shares issued in connection with an Exchange shall be issued in accordance with the registration instructions set forth in the Exchange Notice, in the absence of which they shall be issued in the name of the
applicable Investor. 

  

	7	Notwithstanding anything herein to the contrary, if applicable, no fractional Vaccinex Shares shall be issuable upon exercise of the Exchange Right or in connection with an Exchange. If applicable, the number of
Vaccinex Shares to be issued shall be rounded down to the nearest whole number of Vaccinex Shares. 

  

	8	Prior to the consummation of an applicable Exchange in accordance with this Agreement, no Investor shall have any rights of a holder of Vaccinex Shares, or otherwise as a stockholder of Vaccinex, including, without
limitation, the right to vote on any matter presented to the stockholders of Vaccinex or receive any dividends or distributions on Vaccinex Shares or other shares of Vaccinex stock. Following the consummation of an applicable Exchange in accordance
with this Agreement, the Investors shall not have any rights as a holder of Units, including, without limitation, with respect to the management of LP, any distribution made to the holders of Units or any other interest in LP. 


 

	9	Vaccinex shall reserve and keep available during the term of this Agreement, out of its authorized and unissued shares of common stock, that number of Vaccinex Shares that will from time to time be sufficient to permit
the exercise in full of the Exchange Right. If in connection with the exercise of an Exchange Right, Vaccinex does not have sufficient authorized and unissued Vaccinex Shares to permit the exercise in full of the Exchange Right, Vaccinex will
promptly take such actions as are reasonably necessary to authorize additional Vaccinex Shares to permit the exercise in full of the Exchange Right, subject to applicable laws and the rights of Vaccinex stockholders. 


  
 3 









	10	The Parties hereby represent and warrant to each other as follows: 

  

	 	(a)	Such Party has the full corporate or limited partnership power and authority, as applicable, to execute and deliver this Agreement and to carry out the transactions contemplated hereby; 


 

	 	(b)	The execution and delivery of, and performance by such Party under, this Agreement and the consummation of the transactions contemplated hereby have been duly authorized by all necessary corporate or limited partnership
action, as applicable, on the part of such Party and LP; 

  

	 	(c)	Neither the execution and delivery of this Agreement nor the consummation of the transactions contemplated hereby will (i) violate any provision of the organizational documents of such Party,
(ii) violate any provision of applicable law binding on such Party, or (iii) conflict with, result in a breach of, or constitute a default (or an event which, with notice or lapse of time, or both, would constitute a default)
under any material contract binding on such Party. 

  

	11	LP and VX GP hereby represent and warrant to Vaccinex as follows: 

  

	 	(a)	Schedule A to the LPA sets forth the true, correct and complete capitalization of LP, including all issued and outstanding Units and the holders thereof, and there are no holders of equity interests in or other
securities of LP except for the Investors (all of whom are set forth on such Schedule A) and the general partnership interest of VX GP; and 

  

	 	(b)	Except for the Units set forth on Schedule A to the LPA, there are no outstanding units or other partnership interests in LP, or options, warrants, rights (including conversion or preemptive rights and rights of first
refusal or similar rights) or agreements, orally or in writing, to purchase or acquire from LP any units or partnership interests, or any securities convertible into or exchangeable for units or partnership interests of LP. 


 

	12	Vaccinex hereby represents and warrants to LP and VX GP as follows: all Vaccinex Shares which may be issued upon an Exchange hereunder shall, upon issuance in accordance with this Agreement, be duly authorized, validly
issued, fully paid and nonassessable, and free of any liens and encumbrances except as may be provided herein, restrictions under applicable federal and state securities laws, the certificate of incorporation of Vaccinex, as then in effect, or the
Stockholders Agreements (as defined below) if then in effect, and for such liens and encumbrances as may be created by an Investor. 

  

	13	VX GP and LP hereby covenant and agree that following the date hereof, without the prior written consent of Vaccinex, LP will not (a) issue any Units or any other units or other partnership or equity interests,
including any securities convertible for exchangeable for units or other partnership or equity interests of LP, (b) declare or consummate any split, dividend, combination, subdivision, recapitalization or the like, affecting the Units or
any other unit or partnership or equity interest in LP, or (c) cause or permit the transfer of any Units to any person or entity not listed on Schedule A attached hereto; provided, however, that
(1) Vaccinex may not unreasonably withhold its consent from any proposed transfer of Units to any person or entity 


  
 4 









	 	
which is not an Investor as of the date hereof (as reflected on Schedule A to the LPA as of the date hereof), and (2) any holder of Units may, without the prior written consent of Vaccinex,
transfer Units for bona fide estate planning purposes, either during or after such holder’s lifetime or upon death by will or intestacy, to his or her spouse, child (natural or adopted), or any other direct lineal descendant of such holder (or
of his or her spouse) (all of the foregoing collectively referred to as “Family Members”), or any custodian or trustee of any trust, partnership or limited liability company for the benefit of, or the ownership interests of which
are owned wholly by, such holder or any such family members; provided, that (i) such holder shall deliver prior written notice to Vaccinex of such transfer, (ii) such Units and such transferee(s) shall remain subject
to the terms of this Agreement; and (iii) such transfer shall be permitted by applicable law. 

  

	14	The obligations of Vaccinex to issue Vaccinex Shares and the rights of any holder of Units to receive Vaccinex Shares hereunder in connection with an Exchange are expressly subject to the execution and delivery by any
recipient of Vaccinex Shares (including Investors, as applicable) of joinders or counter-part signature pages to all stockholders agreements binding on holders of Vaccinex Shares and such other documents or instruments as may be reasonably requested
by Vaccinex, which may include transfer instruments with respect to the Units, transfer restrictions applicable to other holders of Vaccinex Shares, representations and warranties of such recipient regarding their ownership of the Units and/or the
Vaccinex Shares or as may be necessary or advisable under United States federal and state securities laws (the “Stockholders Agreements”). 

  

	15	This Agreement shall be effective as of the date first written above upon the execution and delivery hereof by each Party hereto. 

  

	16	This Agreement may be amended by mutual written agreement of Vaccinex and FCMI. 

  

	17	This Agreement may be terminated by mutual written agreement of Vaccinex and FCMI, and shall automatically terminate upon (a) the consummation of the Exchange with respect to all Units or (b) upon
FCMI’s prior written consent (which consent shall not be unreasonably withheld, conditioned or delayed), a merger or consolidation of LP with or into Vaccinex or any of its direct or indirect subsidiaries or controlled affiliates.


  

	18	Any notice, consent, waiver or other communication given under this Agreement must be in writing and may be given by delivering it or sending it by confirmed email addressed: 


to Vaccinex: 
 Attention:
Maurice Zauderer 
 Email: mzauderer@vaccinex.com 

with a copy (which shall not constitute notice) to: 

Attention: Asher M. Rubin 

Email: asher.rubin@hoganlovells.com 

  
 5 








 to LP: 

Attention: Richard Sutin 
 Email:
richard.sutin@nortonrosefulbright.com 
 with a copy (which shall not constitute notice) to: 

Attention: Asher M. Rubin 

Email: asher.rubin@hoganlovells.com 

to FCMI: 
 Attention: Dan
Scheiner 
 Email: dscheiner@friedberg.ca 

Any such communication is deemed to have been delivered on the date of confirmed transmission, unless that day is not a business day in Canada
or in the United States or if such confirmed transmission is not received during normal business hours of the recipient, in which event it will be deemed delivered on the next following business day. Any Party may change its email address for
service by notice given in accordance with the foregoing and any subsequent notice must be sent to such Party at its changed email address. 
  

	19	None of the Parties shall sell, transfer or assign (including by operation of law) its interest in this Agreement without (a) providing reasonable prior written notice to the other Parties, and
(b) subject to Section 13, obtaining the prior written consent of Vaccinex. Any transfer or assignment not permitted under this section shall be null and void and of no effect whatsoever. 


 

	20	The provisions hereof shall inure to the benefit of the Parties and their respective successors and permitted assigns. 

  

	21	Nothing in this Agreement, express or implied, is intended to confer upon any person other than the Parties hereto or their respective successors and permitted assigns and the Investors any rights, remedies,
obligations, or liabilities under or by reason of this Agreement. 

  

	22	Without limiting anything else contained herein, the Parties shall do or cause to be done all such reasonable acts and things as may be necessary, proper, or advisable, consistent with all applicable laws, to consummate
and make effective the transactions contemplated hereby on the terms and subject to the conditions contained herein. Without limiting the foregoing, each Party shall use its commercially reasonable efforts, and the other Parties shall cooperate with
such efforts, to (a) execute and deliver, or cause to be executed and delivered, such further documents and instruments, including tax certifications and documents, in each case as may be necessary or proper in the reasonable judgment of
Vaccinex, to carry out the provisions and purposes of this Agreement and to comply with applicable legal requirements and (b) obtain any consents, approvals or authorization, or effect the notification of or filing with, each person, whether
private or governmental, whose consent or approval is required in order to permit the consummation of the transactions contemplated hereby on the terms and subject to the conditions contained herein. 


 

	23	The construction and performance of this Agreement shall be governed by the laws of the State of Delaware. 

  

	24	This Agreement may be executed in one or more counterparts, each of which will be deemed an original and all of which together will constitute one and the same instrument. This Agreement may be executed through delivery
of duly executed signature pages by facsimile or electronic mail. 

 [signature pages follow] 

  
 6 








 IN WITNESS WHEREOF the Parties have executed this VX3 Exchange Agreement as of the date
first above written. 
  

			
	VX 3 INC.
		
	By:	 	  

	Name:	 	  

	Title:	 	  



 [Signature Page to VX3 Exchange Agreement] 







 IN WITNESS WHEREOF the Parties have executed this VX3 Exchange Agreement as of the date
first above written. 
  

			
	VX3 (DE) LP
	
	By: VX 3 Inc., its general partner
		
	By:	 	  

	Name:	 	  

	Title:	 	  



 [Signature Page to VX3 Exchange Agreement] 







 IN WITNESS WHEREOF the Parties have executed this VX3 Exchange Agreement as of the date
first above written. 
  

			
	VACCINEX, INC.


 
			
		
	By:	 	  

	Name:	 	  

	Title:	 	  



 [Signature Page to VX3 Exchange Agreement] 







 IN WITNESS WHEREOF the Parties have executed this VX3 Exchange Agreement as of the date
first above written. 
  

			
	FCMI PARENT CO.


 
			
		
	By:	 	  

	Name:	 	  

	Title:	 	  



 [Signature Page to VX3 Exchange Agreement] 







 IN WITNESS WHEREOF the Parties have executed this VX3 Exchange Agreement as of the date
first above written. 
  

			
	  

		
	By:	 	  

	Name:	 	  

	Title:	 	  



 [Signature Page to VX3 Exchange Agreement] 







 IN WITNESS WHEREOF the Parties have executed this VX3 Exchange Agreement as of the date
first above written. 
  

			
	  

		
	By:	 	  

	Name:	 	  

	Title:	 	  



 [Signature Page to VX3 Exchange Agreement] 







 IN WITNESS WHEREOF the Parties have executed this VX3 Exchange Agreement as of the date
first above written. 
  

			
	 Joseph Rutman, as bare trustee for:

Jonathan Rutman
 Shawna Rutman Iankelevic

Gerald Ruthman
 Joseph Rutman

Laila Rutman Alter
 Reena Rutman Lauterpacht

	
	  





			
		
	By:	 	  

	Name:	 	  

	Title:	 	  



 [Signature Page to VX3 Exchange Agreement] 







 IN WITNESS WHEREOF the Parties have executed this VX3 Exchange Agreement as of the date
first above written. 
  

			
	  

		
	By:	 	  

	Name:	 	  

	Title:	 	  



 [Signature Page to VX3 Exchange Agreement] 







 IN WITNESS WHEREOF the Parties have executed this VX3 Exchange Agreement as of the date
first above written. 
  

			
	  

		
	By:	 	  

	Name:	 	  

	Title:	 	  



 [Signature Page to VX3 Exchange Agreement] 







 IN WITNESS WHEREOF the Parties have executed this VX3 Exchange Agreement as of the date
first above written. 
  

			
	  

		
	By:	 	  

	Name:	 	  

	Title:	 	  



 [Signature Page to VX3 Exchange Agreement]