EX-10.1



 Exhibit 10.1 

EXECUTION VERSION 
 SHARE
LENDING AGREEMENT 
 Dated as of June 28, 2018 

Among 
 INTREXON CORPORATION
(“Lender”), 
 J.P. MORGAN SECURITIES LLC (“Borrower”) 

And 
 JPMORGAN CHASE BANK,
NATIONAL ASSOCIATION, NEW YORK BRANCH 
 (“Collateral Agent”) 

This AGREEMENT sets forth the terms and conditions under which Borrower may borrow from Lender shares of Common Stock (as defined below). 

The parties hereto agree as follows: 

Section 1. Certain Definitions. The following capitalized terms shall have the following meanings: 

“Business Day” means a day on which regular trading occurs in the principal trading market for the Common Stock and on which
banking institutions in New York City are generally open for business. 
 “Cash” means any coin or currency of the United
States as at the time shall be legal tender for payment of public and private debts. 
 “Clearing Organization” means The
Depository Trust Company, or, if agreed to by Borrower and Lender, such other securities intermediary at which Borrower and Lender maintain accounts. 

“Closing Price” means, on any day and with respect to the Common Stock, (i) if the Common Stock is listed on a national
or regional U.S. securities exchange or is included in the OTC Bulletin Board Service (operated by the Financial Industry Regulatory Authority, Inc.) or any successor thereto, the last reported sale price, regular way, in the principal trading
session on such day on such market or service on which the Common Stock is then listed or is included, as the case may be (or, if the day of determination is not a Business Day, the immediately preceding Business Day), and (ii) if the Common
Stock is not so listed or included or if the last reported sale price is not obtainable (even if the Common Stock is listed on such market or included in such service), the average of the bid prices for the Common Stock obtained from as many dealers
in the Common Stock (which may include Borrower or its affiliates), but not exceeding three, as shall furnish bid prices available to Lender. 

“Collateral” means Eligible Collateral held in the Collateral Account. 







 “Collateral Account” means the account of the Collateral Agent maintained on the
books of JPMorgan Chase Bank, National Association, New York Branch, as custodian, and designated “JPMorgan Chase Bank, National Association, New York Branch, as Collateral Agent of Intrexon Corporation, as pledgee of J.P. Morgan Securities
LLC, as Borrower of Loaned Shares”. Any Eligible Collateral deposited in the Collateral Account shall be segregated from all other assets and property of the Collateral Agent, which segregation may be accomplished by appropriate identification
on the books and records of the Collateral Agent. 
 “Collateral Agent” means JPMorgan Chase Bank, National Association,
New York Branch, in its capacity as collateral agent for Lender hereunder, or any successor thereto under Section 20. 

“Common Stock” means the shares of common stock, no par value, of Lender; provided that, if the Common Stock shall be
exchanged for or converted into any other security, assets and/or other consideration (including cash) as the result of any merger, consolidation, other business combination, reorganization, reclassification, recapitalization or other corporate
action (including, without limitation, a reorganization in bankruptcy), then, effective upon such exchange or conversion, the amount of such other security, assets and/or other consideration received in exchange for one share of Common Stock shall
be deemed to become one share of Common Stock. For purposes of the foregoing, where a share of Common Stock may be converted into or exchanged for more than a single type of consideration based upon any form of shareholder election, such
consideration will be deemed to be the weighted average of the types and amounts of consideration actually received by the holders of the Common Stock. 

“Convertible Notes” means the $200,000,000 aggregate principal amount of 3.50% Convertible Senior Notes due 2023 issued by
Lender. 
 “Cutoff Time” means 10:00 a.m. in the jurisdiction of the Clearing Organization, or such other time on a
Business Day by which a transfer of Loaned Shares must be made by Borrower or Lender to the other, as shall be determined in accordance with market practice, in which case such other time will be the “Cutoff Time.” 

“Eligible Collateral” means any Cash and Eligible Non-Cash Collateral. Each of the
parties to this Agreement hereby agrees that Cash and each item within the definition of Eligible Non-Cash Collateral shall be treated as a “financial asset” as defined by Section 8-102(a)(9) of the UCC. 
 “Eligible Non-Cash
Collateral” means U.S. Treasury bills and notes, any irrevocable letter of credit issued by a bank as defined in Section 3(a)(6)(A)-(C) of the Exchange Act and any other property permitted to serve as collateral securing a loan of
securities under Rule 15c3-3 under the Exchange Act pursuant to exemptive, interpretive or no-action relief or otherwise. 

“Exchange Act” means the Securities Exchange Act of 1934, as amended. 

“Facility Termination Date” means the earliest to occur of (i) October 1, 2023 and (ii) the date, if any, on
which this Agreement is terminated pursuant to Section 15. 

  
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 “Loaned Shares” means shares of Common Stock transferred in a Loan hereunder
until such Common Stock (or identical Common Stock) is transferred back to Lender hereunder; provided that, to the extent Borrower subsequently transfers to another transferee shares of Common Stock initially transferred to Borrower
hereunder, “Loaned Shares” means an equivalent number of identical shares of Common Stock. If, as the result of a stock dividend, stock split or reverse stock split, the number of outstanding shares of Common Stock is
increased or decreased, then the number of outstanding Loaned Shares shall, effective as of the payment or delivery date of any such event, be proportionately increased or decreased, as the case may be. If the outstanding shares of Common Stock
shall be exchanged for or converted into any new or different security or securities, assets and/or other consideration, as described in the definition of “Common Stock,” such new or different security or securities, assets and/or other
consideration shall, effective upon such exchange or conversion, as the case may be, be deemed to become a Loaned Share in substitution for the former Loaned Share for which such exchange is made and in the same proportions as described in the
definition of “Common Stock.” For purposes of return of Loaned Shares by Borrower or purchase or sale of securities pursuant to Section 5 or 11, Borrower may return securities of the same issuer, class and quantity as the Loaned
Shares as adjusted pursuant to the two preceding sentences. 
 “Market Value” means, on any day, (i) with respect to
Common Stock, the most recent Closing Price of the Common Stock prior to such day and (ii) with respect to any Collateral that is (a) Cash, the face amount thereof, (b) a letter of credit, the undrawn amount thereof and (c) any
other security or property, the market value thereof, as determined by the Collateral Agent in accordance with market practice for such securities or property, based on the price for such security or property as of the most recent close of trading
obtained from a generally recognized source or the closing bid quotation at the most recent close of trading obtained from such source, plus accrued interest to the extent not included therein, unless market practice with respect to the valuation of
such securities or property in connection is to the contrary. 
 “Securities Act” means the Securities Act of 1933, as
amended. 
 “Supplemental Indenture” means the supplemental indenture to be dated as of July 3, 2018 between Lender
and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”), to provide for the form, terms and other provisions of the Convertible Notes and which shall supplement the base indenture to be dated as of the same
date between Lender and the Trustee. 
 “UCC” means the Uniform Commercial Code as in effect in the State of New York on
the date hereof and as it may be amended from time to time. 
 Section 2. Loan of Shares; Transfer of Loaned Shares. 

(a) Subject to the terms and conditions of this Agreement, in consideration of Borrower’s agreements hereunder and other good and valuable
consideration (the receipt of which is hereby acknowledged), Lender hereby agrees to lend to Borrower, on the closing date of the initial issuance of the Convertible Notes (the “Closing Date”), 7,479,431 shares of Common Stock
through the issuance by Lender of such Loaned Shares upon the terms, and subject to the conditions, set forth in this Agreement (such issuance and loan, the “Loan”); provided that


  
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Lender shall have no obligation to make the Loan unless the closing of the initial issuance of the Convertible Notes shall have occurred or shall occur substantially contemporaneously therewith.
The Loan shall be confirmed through the book-entry settlement system of the Clearing Organization. The records maintained by the Clearing Organization shall constitute conclusive evidence with respect to the Loan, including the number of shares of
Common Stock that are the subject of the Loan. 
 (b) Notwithstanding anything to the contrary in this Agreement, Borrower shall not be
permitted to borrow or have any right to take delivery of, or otherwise receive or be deemed to have received, any shares of Common Stock hereunder to the extent (but only to the extent) that after receipt of such shares (i) the Section 16
Percentage would exceed 7.5% or (ii) the Share Amount would exceed the Applicable Share Limit. The “Section 16 Percentage” as of any day is the fraction, expressed as a percentage, (A) the numerator of
which is the number of shares of Common Stock that Borrower and any of its affiliates or any other person subject to aggregation with Borrower for purposes of the “beneficial ownership” test under Section 13 of the Exchange Act, or
any “group” (within the meaning of Section 13 of the Exchange Act) of which Borrower is or may be deemed to be a part beneficially owns (within the meaning of Section 13 of the Exchange Act), without duplication, on such day (or,
to the extent that for any reason the equivalent calculation under Section 16 of the Exchange Act and the rules and regulations thereunder results in a higher number, such higher number) and (B) the denominator of which is the number of
shares of Common Stock outstanding on such day. The “Share Amount” as of any day is the number of shares of Common Stock that Borrower and any person whose ownership position would be aggregated with that of Borrower (Borrower or
any such person, a “Borrower Person”) under any law, rule, regulation, regulatory order or organizational documents or contracts of Lender that are, in each case, applicable to ownership of shares of Common Stock
(“Applicable Restrictions”), owns, beneficially owns, constructively owns, controls, holds the power to vote or otherwise meets a relevant definition of ownership under any Applicable Restriction, as determined by Borrower in its
reasonable discretion. The “Applicable Share Limit” means a number of shares of Common Stock equal to (A) the minimum number of shares of Common Stock that could give rise to reporting or registration obligations or other
requirements (including obtaining prior approval from any person or entity) of a Borrower Person, or could result in an adverse effect on a Borrower Person, under any Applicable Restriction, as determined by Borrower in its reasonable discretion,
minus (B) 1% of the number of shares of Common Stock outstanding. If any delivery owed to Borrower hereunder is not made, in whole or in part, as a result of a limitation set forth in this paragraph, Lender’s obligation to make such
delivery shall not be extinguished and Lender shall make such delivery as promptly as practicable after, but in no event later than one Business Day after, Borrower gives notice to Lender that such delivery would not result in any such limitation
being breached. If, notwithstanding the foregoing, any delivery of Common Stock is erroneously made to Borrower or Borrower otherwise receives or is deemed to have received Common Stock in excess of the foregoing limitation contrary to the first
sentence of this paragraph, such Common Stock shall remain the property of Lender and Borrower shall be deemed to hold the same as bailee of Lender and shall have no voting, dispositive control or pecuniary interest with respect thereto. 

  
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 (c) Lender shall transfer Loaned Shares to Borrower on or before the Cutoff Time on the Closing
Date. Delivery of the Loaned Shares to Borrower shall be made in the manner set forth under Section 13 below. 
 Section 3.
Collateral. 
 (a) Borrower shall, no later than the close of business on the Closing Date, transfer to Collateral Agent, for deposit
to the Collateral Account, Eligible Collateral with a Market Value at least equal to the Market Value of the Loaned Shares as of the Closing Date. 

(b) Any Eligible Collateral deposited into the Collateral Account shall be security for Borrower’s obligations in respect of the Loaned
Shares and for any other obligations of Borrower to Lender hereunder. Borrower hereby pledges, collaterally assigns and grants to Collateral Agent for the benefit of Lender a continuing first priority security interest in, and a lien upon, the
Collateral, which shall attach upon transfer of the Loaned Shares by Lender to Borrower and which shall cease upon the transfer of any such Collateral to Borrower in accordance with the terms of this Agreement. In addition to the rights and remedies
given to Lender hereunder, Lender shall have all the rights and remedies of a secured party under the UCC. Notwithstanding anything to the contrary herein, Lender may not use or invest the Collateral and Collateral Agent shall take no instruction
from Lender regarding the use or investment of Collateral, except as set forth in Section 11. 
 (c) Following the transfer to Lender
of Loaned Shares pursuant to Section 5, Collateral Agent shall release to Borrower Collateral with a Market Value equal to the Market Value of the Loaned Shares so transferred but only to the extent that immediately following such transfer of
Collateral, no Collateral Deficit would exist; provided that in the case of (x) a transfer to Lender of all outstanding Loaned Shares, (y) payment in full of Replacement Cash to Lender pursuant to Section 11(b) or
(z) satisfaction of all Borrower’s obligations hereunder as a result of the purchase of Replacement Shares pursuant to Section 11(d), Collateral Agent shall release all of the Collateral to Borrower. Such transfer of Collateral shall
be made no later than the Cutoff Time on the day the Loaned Shares are transferred, or if such day is not a day on which a transfer of such Collateral may be effected under Section 13, or if the transfer of Loaned Shares by Lender to Borrower
occurs after the Cutoff Time on such day, then in each case the next day on which such a transfer may be effected. 
 (d) If Borrower
transfers Collateral to Collateral Agent, as provided in this Section 3, and Lender does not transfer the Loaned Shares to Borrower, Borrower shall have the absolute right to the return of the Collateral; and if Lender transfers Loaned Shares
to Borrower and Borrower does not transfer Collateral to Collateral Agent as provided in this Section 3, Lender shall have the absolute right to the return of the Loaned Shares. 

(e) Borrower may, upon notice to Lender and Collateral Agent, substitute Eligible Collateral for Collateral securing the Loan; provided
that such substituted Eligible Collateral shall have a Market Value such that the aggregate Market Value of such substituted Eligible Collateral, together with all other Collateral, shall equal or exceed the Market Value of the Loaned Shares as of
the date of such substitution. 

  
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 (f) Lender hereby appoints Collateral Agent to act as its agent for purposes of holding
Collateral hereunder and otherwise complying with the terms hereof. Collateral Agent accepts such appointment; provided that Collateral Agent shall have no duties or obligations except those expressly set forth herein. Without limiting the
generality of the foregoing, Collateral Agent shall not be subject to any fiduciary or other implied duties. Collateral Agent shall have no liability for any action taken or omitted to be taken in accordance with the terms of this Agreement. 

Section 4. Mark to Market. 

(a) Borrower shall daily mark to market the Loan hereunder, and if at the close of trading on any Business Day the aggregate Market Value of
all Collateral shall be less than the Market Value of all the outstanding Loaned Shares (a “Collateral Deficit”), Borrower shall transfer to Collateral Agent, for deposit to the Collateral Account, no later than the following
Business Day, additional Collateral so that the Market Value of such additional Collateral, when added to the Market Value of all other Collateral, shall equal or exceed the Market Value of the Loaned Shares on such Business Day of determination.

 (b) If at the close of trading on any Business Day the aggregate Market Value of all Collateral shall be greater than the Market Value of
all the outstanding Loaned Shares (a “Collateral Excess”), Borrower may, by notice to Collateral Agent, demand that Collateral Agent transfer to Borrower such amount of the Collateral selected by Borrower so that the Market Value of
the Collateral, after deduction of such amounts, shall thereupon be at least equal to the Market Value of the Loaned Shares on such Business Day of determination; provided that no Collateral Excess shall be returned to Borrower if at the time
of transfer a Borrower Default has occurred and is continuing. 
 Section 5. Loan Terminations. 

(a) Borrower may terminate all or any portion of the Loan on any Business Day by giving written notice thereof to Lender and transferring the
corresponding number of Loaned Shares to Lender no later than the fifth Business Day following the date of such notice, without any consideration being payable in respect thereof by Lender to Borrower; provided that such termination shall not
relieve Borrower from the obligation to make such other payments and/or deliveries required to be made by it to Lender hereunder, including any such payments and/or deliveries pursuant to Section 6 hereof. Any such Loan termination shall be
effective immediately upon delivery of the applicable Loaned Shares in accordance with the terms hereof. 
 (b) Subject to Section 11
below, the Loan shall terminate on the Facility Termination Date, and all Loaned Shares, if any, then outstanding shall be delivered by Borrower to Lender, without any consideration being payable in respect thereof by Lender to Borrower, no later
than the fifth Business Day following the Facility Termination Date; provided that such termination shall not relieve Borrower from the obligation to make such other payments and/or deliveries required to be made by it to Lender hereunder,
including any such payments and/or deliveries pursuant to Section 6 hereof. 

  
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 (c) Subject to Section 11 below, if the Loan is terminated upon the occurrence of a Default
as set forth in Section 10, the Loaned Shares shall be delivered by Borrower to Lender, without any consideration being payable in respect thereof by Lender to Borrower, no later than the fifth Business Day following the termination date of the
Loan as provided in Section 10; provided that such termination shall not relieve Borrower from the obligation to make such other payments and/or deliveries required to be made by it to Lender hereunder, including any such payments and/or
deliveries pursuant to Section 6 hereof. 
 Section 6. Distributions. 

(a) If, at any time when there are Loaned Shares outstanding under this Agreement, Lender pays a cash dividend or makes a cash distribution in
respect of all its outstanding shares of Common Stock, Borrower shall pay to Lender (whether or not Borrower is a holder of any or all of the outstanding Loaned Shares), within five Business Days after the payment of such dividend or distribution,
an amount in cash equal to the product of (i) the amount per share of Common Stock of such dividend or distribution, as the case may be, and (ii) the number of Loaned Shares outstanding at such time; provided that if Borrower
returns any Loaned Shares to Lender following a record date for such a dividend or distribution on such Loaned Shares but prior to the payment of such dividend or distribution on such Loaned Shares, Borrower shall nonetheless pay to Lender the
amount of such dividend or distribution, as the case may be, within five Business Days after the payment of such dividend or distribution. 

(b) If, at any time when there are Loaned Shares outstanding under this Agreement, Lender makes a distribution in respect of its outstanding
Common Stock (other than a distribution upon liquidation or a reorganization in bankruptcy) in property or securities, other than a distribution of Common Stock, including any options, warrants, rights or privileges in respect of securities
(including any options, warrants, rights or privileges exercisable for, convertible into or exchangeable for Common Stock) to the then holder or holders of such Loaned Shares (a “Non-Cash
Distribution”), Borrower shall, at its option, either (i) deliver to Lender (whether or not Borrower is a holder of any or all of the outstanding Loaned Shares) in kind, within five Business Days after the date of such Non-Cash Distribution, the property or securities distributed in an amount equal to the product of (x) the amount per share of Common Stock of such Non-Cash Distribution
and (y) the number of Loaned Shares on the record date for such Non-Cash Distribution or (ii) elect that the number of Loaned Shares then outstanding under this Agreement shall be deemed adjusted in
the same manner as the conversion rate of the Convertible Notes is required to be adjusted in respect of such Non-Cash Distribution; provided that if Borrower returns any Loaned Shares to Lender
following a record date for such a distribution on such Loaned Shares but prior to the payment of such distribution on such Loaned Shares, Borrower shall nonetheless comply with the provisions of this subsection (b) as if such Loaned Shares
were outstanding on the date of such distribution. 
 (c) Any interest or other cash payment made on or in respect of any Collateral
hereunder shall, subject to subsection (e) below, be delivered by the Collateral Agent to Borrower on the date such interest or other cash payment is received by the Collateral Agent. 

  
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 (d) Any non-cash distribution made on or in respect of
any Collateral hereunder shall, subject to subsection (e) below, be delivered by the Collateral Agent to Borrower on the date such non-cash distribution is received by the Collateral Agent. 

(e) If the cash or other property received by the Collateral Agent under the provisions of subsection (c) or (d) of this Section 6
qualifies as Collateral, to the extent that a transfer of such cash or other property to Borrower by the Collateral Agent would give rise to a Collateral Deficit, the Collateral Agent shall (only to the extent of any such Collateral Deficit) not
make such transfer of cash or other property in accordance with this Section 6, but shall in lieu of such transfer immediately credit the amounts that would have been transferable under this Section 6 to the Collateral Account. 

Section 7. Rights in Respect of Loaned Shares. 

Subject to the terms of this Agreement, including Borrower’s obligation to return the Loaned Shares in accordance with the terms of this
Agreement, and except as otherwise agreed by Borrower and Lender or Borrower and any subsequent transferee of Loaned Shares, insofar as such person is the owner of any such Loaned Shares, such person shall have all of the incidents of ownership in
respect of any such Loaned Shares, including the right to transfer the Loaned Shares to others. 
 Section 8. Representations and
Warranties. 
 (a) Each of Borrower and Lender represent and warrant to the other that: 

(i) it has full power to execute and deliver this Agreement, to enter into the Loan contemplated hereby and to perform its obligations
hereunder; 
 (ii) it has taken all necessary action to authorize such execution, delivery, entry and performance; 

(iii) this Agreement constitutes its legal, valid and binding obligation, enforceable against it in accordance with its terms, subject to
applicable bankruptcy, insolvency, fraudulent conveyance, reorganization, moratorium and similar laws affecting creditors’ rights and remedies generally, and subject, as to enforceability, to general principles of equity, including principles
of commercial reasonableness, good faith and fair dealing (regardless of whether enforcement is sought in a proceeding at law or in equity) and except that rights to indemnification and contribution hereunder may be limited by federal or state
securities laws or public policy relating thereto; and 
 (iv) the execution, delivery and performance of this Agreement does not and will
not violate, contravene, or constitute a default under, (A) its certificate or articles of incorporation, bylaws or other governing documents, (B) any laws, rules or regulations of any governmental authority to which it is subject,
(C) any material contracts, agreements or instrument to which it is a party or (D) any judgment, injunction, order or decree by which it is bound. 

  
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 (b) Lender represents and warrants to Borrower, as of the date hereof, and as of the date the
Loaned Shares are transferred to Borrower in respect of the Loan hereunder, that the Loaned Shares and all other outstanding shares of Common Stock of Lender have been duly authorized and, upon the issuance and delivery of such Loaned Shares to
Borrower in accordance with the terms and conditions hereof, will be duly authorized, validly issued, fully paid non-assessable shares of Common Stock, and the shareholders of Lender have no preemptive rights
with respect to such Loaned Shares. 
 (c) Lender represents and warrants to Borrower, as of the date hereof, and as of the date the Loaned
Shares are transferred to Borrower in respect of the Loan hereunder, that all of the Loaned Shares have been approved for listing on The New York Stock Exchange, subject to official notice of issuance. 

(d) Borrower represents to Lender that it has, or at the time of transfer to the Collateral Agent shall have, the right to grant to Lender,
and Lender shall acquire a continuing first priority security interest in the Collateral. 
 (e) Lender acknowledges that Borrower is not
making any representations or warranties or taking any position or expressing any view with respect to the treatment of this Agreement or the Loan under any accounting standards. 

(f) Lender acknowledges that it has received the disclosures attached hereto as Annex A. 

(g) Lender represents and warrants that no state or local (including non-U.S. jurisdictions) law,
rule, regulation or regulatory order applicable to the Common Stock due to the nature of Lender’s or any of its subsidiaries’ business (excluding banking laws, rules, regulations or regulatory orders and any other law, rule, regulation or
regulatory order that is applicable to Borrower due to the nature of Borrower’s business) in any jurisdiction in which Lender or any subsidiary thereof is organized, conducts business, operates or is licensed on the date hereof would give rise
to any reporting, consent, registration or other requirement (including without limitation a requirement to obtain prior approval from any person or entity) solely as a result of Borrower or its affiliates owning or holding (however defined) shares
of Common Stock due to the nature of Lender’s or any of its subsidiaries’ business. 
 (h) Lender represents and warrants that it
is entering into this Agreement in good faith and not as part of a plan or scheme to evade compliance with federal securities laws including, without limitation, Rule 10b-5 under the Exchange Act or any other
antifraud or anti-manipulation provisions of the federal or applicable state securities laws. 
 (i) Lender represents and warrants to
Borrower, as of the date the Loaned Shares are transferred to Borrower in respect of the Loan hereunder, that Lender is not “insolvent” (as such term is defined under Section 101(32) of Title 11 of the United States Code (the
“Bankruptcy Code”) and Lender would be able to purchase the number of shares of Common Stock lent hereunder in compliance with the corporate law of Lender’s jurisdiction of incorporation. 

(j) Lender represents and warrants to Borrower that, as of the date hereof, and as of the date the Loaned Shares are transferred to Borrower
in respect of the Loan hereunder, Lender is not, and will not be required to register as, an “investment company” as such term is defined in the Investment Company Act of 1940, as amended. 

  
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 (k) Lender represents and warrants to Borrower that Lender (A) is capable of evaluating
investment risks independently, both in general and with regard to all transactions and investment strategies involving a security or securities; (B) will exercise independent judgment in evaluating the recommendations of any broker-dealer or
its associated persons, unless it has otherwise notified the broker-dealer in writing; and (C) has total assets of at least $50 million as of the date hereof. 

(l) Lender represents and warrants that it (and any successor entity) is, and at any time during which a Loan made pursuant to this Agreement
is outstanding will be, a United States person within the meaning of Section 7701(a)(30) of the U.S. Internal Revenue Code of 1986, as amended (the “Code”). 

(m) Borrower represents and warrants that it (and any successor entity) is, and at any time during which a Loan made pursuant to this
Agreement is outstanding will be, a United States person within the meaning of Section 7701(a)(30) of the Code. 
 (n) Borrower
represents and warrants to Lender that any shares of Common Stock that Borrower transfers to Lender in respect of any Loan termination, and any property or securities comprising any Non-Cash Distribution that
Borrower transfers to Lender, in each case, shall be made free from any lien, charge, claim or other encumbrance or restrictions (other than (x) a lien, charge, claim or other encumbrance or restriction routinely imposed on all securities by
the relevant Clearance System and (y) any lien, charge, claim or other encumbrance or restriction (i) in the case of any shares of Common Stock, that exists in respect to all outstanding shares of Common Stock and (ii) in the case of
any property or securities comprising any Non-Cash Distribution, that exists in respect of all such property or securities so distributed). 

(o) The representations and warranties of Borrower and Lender under this Section 8 shall remain in full force and effect at all times
during the term of this Agreement and shall survive the termination for any reason of this Agreement. 
 Section 9. Covenants.

 (a) The parties hereto acknowledge that Borrower has informed Lender that Borrower is a “financial participant” within the
meaning of Section 101(22A) of the Bankruptcy Code. The parties hereto further acknowledge and agree that (i) the Loan hereunder is intended to be a “securities contract,” as such term is defined in Section 741(7) of the
Bankruptcy Code; (ii) each and every transfer of funds, securities and other property under this Agreement is intended to be a “transfer” and a “settlement payment” or a “margin payment,” as such terms are used in
Section 546(e) of the Bankruptcy Code; and (iii) Borrower is intended to be entitled to the protections afforded by, among other sections, Sections 362(b)(6), 546(e), 555 and 561 of the Bankruptcy Code. 

(b) Lender shall, no later than five Business Days prior to any repurchase of Common Stock, give Borrower a written notice of such repurchase
(a “Repurchase Notice”) if, following such repurchase, the Outstanding Borrow Percentage as determined on such day after giving 

  
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effect to such repurchase would be greater than 5.0% or, after the first such Repurchase Notice, greater by 0.5% than the Outstanding Borrow Percentage included in the immediately preceding
Repurchase Notice. The “Outstanding Borrow Percentage” as of any day is the fraction (A) the numerator of which is the aggregate number of Loaned Shares outstanding on such day and (B) the denominator of which is the
number of shares of Common Stock outstanding on such day, including such Loaned Shares. 
 (c) Lender covenants and agrees that, unless
otherwise agreed to by Borrower in writing, Lender shall not, and shall not permit any of its direct or indirect subsidiaries, or any entity or person controlled by Lender, to, directly or indirectly, purchase shares of Common Stock if, after giving
effect to such purchase, the Outstanding Borrow Percentage shall be greater than 7.5%. 
 (d) Borrower covenants and agrees with Lender
that, insofar as Borrower or any of its affiliates is the record owner of any Loaned Shares, Borrower shall use good faith efforts to use such Loaned Shares solely for the purpose of directly or indirectly facilitating the sale of the Convertible
Notes and hedging activities (including short sales of such Loaned Shares) relating to the Convertible Notes by the holders thereof. 
 (e)
Lender covenants and agrees that upon the occurrence of any event described in the definition of “Common Stock” that results in the right of holders of Common Stock to receive more than one type of consideration based upon any form of
shareholder election, Lender shall notify Borrower promptly (but in any case prior to the effective date of such event) of the weighted average of the types and amounts of consideration actually received by the holders of the Common Stock. 

(f) Borrower and Lender agree to deliver the following documents, as applicable: 

 

					
	 Party required to

deliver document
	  	 Form/Document/

Certificate
	  	 Date by which to be

delivered

	Borrower	  	A complete and accurate U.S. Internal Revenue Service Form W-9 (or successor thereto).	  	(A) Prior to becoming a party to this Agreement and (B) promptly upon learning that any form or other document previously provided to Collateral Agent or Lender has become obsolete or incorrect.
	Lender	  	A complete and accurate U.S. Internal Revenue Service Form W-9 (or successor thereto).	  	(A) Prior to becoming a party to this Agreement and (B) promptly upon learning that any form or other document previously provided to Borrower has become obsolete or incorrect.


  
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 Section 10. Events of Default. The Loan may, at the option of Lender (in the
case of a Default by Borrower) or Borrower (in the case of a Default by Lender) by a written notice to the other parties (which option shall be deemed exercised, even if no notice is given, immediately on the occurrence of an event specified in
Section 10(e) or 10(f) below), be terminated (1) immediately on the occurrence of any of the events set forth in Section 10(e) or 10(f) below or (2) two Business Days following such notice on the occurrence of any of the other
events set forth below (each, a “Default”): 
 (a) Borrower fails to deliver Loaned Shares to Lender as required by
Section 5; 
 (b) Borrower or Lender fails to deliver or pay to Lender or Borrower, respectively, when due any cash, securities or
other property as required by Section 6 or otherwise; 
 (c) Borrower or Lender fails to transfer or return Collateral when due as
required by Section 3 and Section 4 or otherwise; 
 (d) Borrower or Lender fails to pay Lender or Borrower, respectively, any
amount when due as required by Section 11; 
 (e) the filing by or on behalf of Lender or Borrower of a voluntary petition or an answer
seeking reorganization, arrangement, readjustment of its debts or for any other relief under any bankruptcy, reorganization, compromise, arrangement, insolvency, readjustment of debt, dissolution, moratorium, delinquency, winding-up or liquidation or similar act or law, of any state, federal or other applicable foreign jurisdictions, now or hereafter existing (“Bankruptcy Law”), or any action by such party for, or
consent or acquiescence to, the appointment of a receiver, trustee, conservatory, custodian or similar official of such party, or of all or a substantial part of its property; or the making by such party of a general assignment for the benefit of
creditors; or the admission by such party in writing of its inability to pay its debts as they become due; 
 (f) the filing of any
involuntary petition against Lender or Borrower in bankruptcy or seeking reorganization, arrangement, readjustment of its debts or for any other relief under any Bankruptcy Law and an order for relief by a court having jurisdiction in the premises
shall have been issued or entered therein; or any other similar relief shall be granted under any applicable federal or state law or law of any other applicable foreign jurisdictions; or a decree or order of a court having jurisdiction in the
premises for the appointment of a receiver, liquidator, sequestrator, trustee or other officer having similar powers over such party or over all or a part of its property shall have been entered; or the involuntary appointment of an interim
receiver, trustee or other custodian of such party or of all or a substantial part of its property or the issuance of a warrant of attachment, execution or similar process against any substantial part of


  
 12 








 
the property of such party; and continuance of any such event for 15 consecutive calendar days unless dismissed, bonded to the satisfaction of the court having jurisdiction in the premises or
discharged; 
 (g) Lender fails to provide any indemnity as required by Section 14; provided that Borrower may waive such
Default by Lender in its sole discretion; 
 (h) Borrower or Lender notifies Lender or Borrower, respectively, of its inability to or
intention not to perform its obligations hereunder or otherwise disaffirms, fails to perform, rejects or repudiates any of its obligations hereunder; or 

(i) any representation made by Borrower or Lender under this Agreement shall be incorrect or untrue in any material respect when made or
Borrower or Lender fails to comply in any material respect with any of its covenants under this Agreement. 
 Section 11. Right to
Extend; Lender’s Remedies. 
 (a) Except to the extent the Loan is terminated pursuant to Section 5(c) as a
result of a Default by Borrower, Borrower may, following the termination of all or any portion of the Loan pursuant to Section 5, delay the date on which the related Loaned Shares are due to Lender for up to an additional 75 Business Days (the
“Settlement Due Date”, as so delayed to the extent applicable), with respect to some or all (as the case may be) of such Loaned Shares, if Borrower reasonably determines in good faith based on the advice of counsel that such
extension with respect to some or all (as the case may be) of such Loaned Shares is reasonably necessary to enable Borrower (or any of its affiliates) to effect purchases of Common Stock related to the delivery of Loaned Shares due to Lender in
connection with this Agreement in a manner that (x) would be in compliance with (i) legal and regulatory requirements or related policies and procedures applicable to Borrower or such affiliates in purchasing such shares of Common Stock or
(ii) legal and regulatory requirements that would be applicable if Borrower were deemed to be Lender or an affiliated purchaser of Lender in purchasing such shares of Common Stock and (y) shall not be commercially impracticable, in the
reasonable judgment of Borrower, in the time period required by Section 5. 
 (b) Upon the termination of the Loan by Lender or
Borrower under Section 10, Borrower may, with the prior written consent of Lender (solely in the case of a termination of the Loan by Lender), in lieu of the delivery of Loaned Shares to Lender in accordance with Section 5(c), pay to
Lender, no later than five Business Days following notice of such Default, an amount in immediately available funds (the “Replacement Cash”) equal to the Market Value of the Loaned Shares otherwise required to be delivered as of the
date of such notice of Default; provided that Borrower may direct the Collateral Agent to deliver to Lender any Collateral held by the Collateral Agent in respect of the Loan so terminated and, to the extent the Market Value of any such
Collateral delivered to Lender is less than the required amount of Replacement Cash, pay to Lender such difference in immediately available funds. Any Collateral in respect of the Loan so terminated that is not so delivered to Lender pursuant to
this subsection shall, upon payment in full of the Replacement Cash to Lender, be immediately delivered by Collateral Agent to Borrower. 

  
 13 








 (c) If, upon the termination of the Loan as a result of a Default by Borrower under
Section 5(c), the purchase of Common Stock in an amount equal to all or any portion of the Loaned Shares to be delivered to Lender by Borrower in accordance with Section 5(c) of this Agreement (i) shall be prohibited by any law, rules
or regulation of any governmental authority to which it is or would be subject or any related policies and procedures, (ii) shall violate, or would upon such purchase reasonably likely violate, any order or prohibition of any court, tribunal or
other governmental authority, (iii) shall require the prior consent of any court, tribunal or governmental authority prior to any such repurchase, (iv) would subject Borrower, based on the advice of counsel to the Borrower, to any
liability or potential liability under any applicable federal securities laws (including, without limitation, Section 16 of the Exchange Act) or (v) shall be commercially impracticable in the time period required by Section 5(c), in
the commercially reasonable judgment of Borrower as a result of a demonstrable legal or regulatory impediment (including regulations of self-regulatory organizations) to such purchases (each of (i), (ii), (iii), (iv) and (v), a “Legal
Obstacle”), then, in each case, Borrower shall immediately notify Lender of the Legal Obstacle and the basis therefor, whereupon Borrower’s obligations under Section 5(c) shall be suspended until such time as no Legal Obstacle
with respect to such obligations shall exist (a “Repayment Suspension”). Following the occurrence of and during the continuation of any Repayment Suspension, Borrower shall use commercially reasonable efforts to remove or cure the
Legal Obstacle as promptly as reasonably practicable; provided that (except in circumstances where the Legal Obstacle resulted from the failure by Borrower to comply with applicable securities laws or regulations) Lender shall promptly
reimburse all reasonable actual out-of-pocket costs and expenses (including of legal counsel to Borrower) incurred or, at Borrower’s election, provide reasonably
adequate surety or guarantee for any such costs and expenses that may be incurred by Borrower, in each case, in removing or curing such Legal Obstacle; and provided further that, if Borrower cannot remove or cure the Legal Obstacle
within ten Business Days, then Lender shall have the right, exercisable in its sole discretion, to (x) notify Borrower of its election that Borrower pay to Lender, in lieu of the Loaned Shares otherwise due in accordance with Section 5(c),
Replacement Cash in an amount equal to the Market Value as of the date of such notice of the Loaned Shares otherwise due and (y) direct the Collateral Agent to, and the Collateral Agent upon receipt of the written request of Lender (with a copy
to Borrower but without any further consent of Borrower) shall, release to Lender an amount of Collateral with a Market Value as of the date of such notice to Borrower equal to the amount of such Replacement Cash, whereupon the Borrower’s
obligation to return the specified number of Loaned Shares to the Lender or to pay such Replacement Cash shall be automatically extinguished. 

(d) If Borrower shall fail to deliver Loaned Shares to Lender pursuant to Section 5(c) when due or shall fail to pay the Replacement Cash
to Lender when due in accordance with Section 11(b) or (c) above, then, in either case, in addition to any other remedies available to Lender under this Agreement or under applicable law, Lender shall have the right (upon prior written
notice to Borrower) to purchase a like amount of Loaned Shares (“Replacement Shares”) in the principal market for such securities in a commercially reasonable manner. To the extent Lender shall exercise such right,
(i) Borrower’s obligation to return a like amount of Loaned Shares or to pay the Replacement Cash, as applicable, shall terminate and Borrower shall be liable to Lender for the purchase price of Replacement Shares, (ii) Lender shall
have the right to direct the Collateral Agent to, and the Collateral Agent upon receipt of the written request of Lender (which request shall identify the failure giving rise to such right with specificity, contain


  
 14 








 
a certification that such failure has occurred and state that Lender is exercising its rights under this Section 11(d)) and without any further consent of Borrower shall, sell any Collateral
in the principal market for such Collateral in a commercially reasonable manner and (iii) Lender shall have the right to apply and set off the Collateral and any proceeds thereof (including any amounts drawn under a letter of credit supporting
the Loan) against the payment of the purchase price for such Replacement Shares (plus all other amounts, if any, due to Lender hereunder). In the event that (x) the purchase price of Replacement Shares (plus all other amounts, if
any, due to Lender hereunder) exceeds (y) the Market Value of the Collateral, Borrower shall be liable to Lender for the amount of such excess. The purchase price of Replacement Shares purchased under this Section 11 shall include, and the
proceeds of any sale of Collateral shall be determined after deduction of, brokers’ fees and commissions and all other reasonable costs, fees and expenses related to such purchase and sale. In the event Lender exercises its rights under this
Section 11, Lender may elect in its sole discretion, in lieu of purchasing all or a portion of the Replacement Shares or selling all or a portion of the Collateral, to be deemed to have made, respectively, such purchase of Replacement Shares or
sale of Collateral for an amount equal to the Closing Price of the Common Stock on the date Lender elects to exercise this remedy. Upon the satisfaction of all Borrower’s obligations hereunder, any remaining Collateral shall be returned to
Borrower. 
 (e) If upon Lender’s instruction the Collateral Agent fails to transfer Collateral, if any, to Borrower when due as
required by Section 3 and Section 4, or if a Default shall occur with respect to Lender, then Borrower shall have the right (without further notice to Lender) to (i) purchase a like amount of Collateral (which amount may be all of the
Collateral in the case of a Default with respect to Lender) (“Replacement Collateral”) in the principal market for such Collateral in a commercially reasonable manner, (ii) sell a like amount of Loaned Shares in the principal
market for such Loaned Shares in a commercially reasonable manner and (iii) apply and set off Borrower’s obligation to return such Loaned Shares and any proceeds thereof against the payment of the purchase price for such Replacement
Collateral, Lender’s obligation to return any cash or other Collateral to Borrower and any amounts due to Borrower under this Agreement. To the extent Borrower shall exercise such right, Lender’s obligation to return a like amount of
Collateral shall terminate. In the event that (i) the purchase price of Replacement Collateral (plus all other amounts, if any, due to Lender hereunder) exceeds (ii) the sale price of the Loaned Shares, Lender shall be liable to Borrower
for the amount of such excess. The purchase price of Replacement Collateral purchased under this Section 11 shall include, and the proceeds of any sale of Loaned Shares shall be determined after deduction of, broker’s fees and commissions
and all other reasonable costs, fees and expenses related to such purchase and sale. In the event Borrower exercises its rights under this Section 11, Borrower may elect in its sole discretion, in lieu of selling all or a portion of the Loaned
Shares or purchasing all or a portion of the Replacement Collateral, to be deemed to have made, respectively, such sale of Loaned Shares or such purchase of the Replacement Collateral for an amount equal to the Closing Price of the Loaned Shares or
the Market Value of the Collateral, respectively, on the date Borrower elects to exercise this remedy. Upon the satisfaction of all Lender’s obligations hereunder, any remaining Loaned Shares shall be returned to Lender. 

(f) Notwithstanding anything to the contrary, the parties hereto agree that no special, indirect or consequential damages shall be due in
connection with, arising out of, or in relation to this Agreement. 

  
 15 








 Section 12. Transfer Taxes. 

All transfer taxes with respect to the transfer of the Loaned Shares by Lender to Borrower and by Borrower to Lender upon termination of the
Loan and with respect to the transfer of Collateral by Borrower to Collateral Agent and by Collateral Agent to Borrower upon termination of the Loan or pursuant to Section 3(e) or Section 4 shall be paid by Lender. 

Section 13. Transfers. 

(a) All transfers of Loaned Shares to Borrower hereunder shall be made by the crediting by a Clearing Organization of such Loaned Shares to
Borrower’s “securities account” (within the meaning of Section 8-501 of the UCC) designated by Borrower and maintained with such Clearing Organization. All transfers of Loaned Shares to Lender hereunder shall be made by the
crediting by a Clearing Organization of such Loaned Shares to Lender’s “securities account” (within the meaning of Section 8-501 of the UCC) designated by Lender and maintained with such Clearing Organization; provided
that, if Lender does not provide all relevant details with respect to such “securities account” to Borrower promptly upon request, Borrower shall be deemed to have satisfied its obligation to transfer Loaned Shares to Lender under
Section 5 upon its notice to Lender that such Loaned Shares are available for transfer, and thereafter Borrower shall be deemed to hold the same as bailee of Lender. In every transfer of Loaned Shares hereunder, the transferor shall take all
steps necessary (a) to effect a delivery to the transferee under Section 8-301 of the UCC, or to cause the creation of a security entitlement in favor of the transferee under Section 8-501 of the UCC, (b) to enable the transferee
to obtain “control” (within the meaning of Section 8-106 of the UCC), and (c) to provide the transferee with comparable rights under any applicable foreign law or regulation that is applicable to such transfer. 

(b) All transfers of cash hereunder to Borrower or Lender shall be by wire transfer in immediately available, freely transferable funds. 

(c) A transfer of securities or cash may be effected under this Section 13 on any day except (i) a day on which the transferee is
closed for business at its address set forth in Section 16 or (ii) a day on which a Clearing Organization or wire transfer system is closed, if the facilities of such Clearing Organization or wire transfer system are required to effect
such transfer, in which case under clause (i) or (ii), such transfer shall be made on the immediately following day on which such exceptions are not in effect. 

(d) To the extent permitted by law, neither this Agreement nor any interest or obligation in or under this Agreement may be transferred
(whether by way of security or otherwise) by any party without the prior written consent of the other parties; provided that Borrower may, without the consent of Lender, transfer or assign all or any part of its rights or obligations under
this Agreement to any of Borrower’s affiliates (i) if Borrower determines that such transfer is required or advisable in light of legal and regulatory requirements or related policies and procedures applicable to Borrower or its affiliates
or (ii) if, absent such transfer, Borrower or any of its affiliates would incur a materially increased cost or other increased expense (compared to such cost of expenses as of the date hereof) or would experience any other material adverse
effect so long as such transfer or assignment would not reasonably be expected to result in 

  
 16 








 
materially adverse tax consequences for Lender and (x) such affiliate has a long-term issuer rating that is equal to or better than Borrower’s credit rating at the time of such transfer
or assignment, (y) such affiliate’s obligations hereunder will be guaranteed, pursuant to the terms of a customary guarantee in a form used by Borrower generally for similar transactions, by Borrower or JPMorgan Chase & Co. or
(z) such affiliate has a long-term issuer rating equal to or better than A- by Standard and Poor’s Rating Group, Inc. or its successor (“S&P”) or A3 by Moody’s Investor
Service, Inc. or its successor (“Moody’s”) or, if either S&P or Moody’s ceases to rate such debt, at least an equivalent rating or better by a substitute rating agency mutually agreed by Borrower and Lender. Subject to
the foregoing, this Agreement shall be binding upon and shall inure to the benefit of Borrower, Lender and their respective successors and permitted assigns. Any purported transfer that is not in compliance with this Section 13(d) shall be null
and void 
 Section 14. Indemnification. 

(a) Lender hereby agrees to indemnify and hold harmless Borrower and its affiliates and its former, present and future directors, officers and
employees from and against any and all liabilities, judgments, claims, settlements, losses, damages and other expenses (including, without limitation, direct losses relating to Borrower’s market activities as a consequence of becoming subject
to Section 16(b) under the Exchange Act, and including, without limitation, any forbearance from market activities or cessation of market activities and any losses in connection therewith or with respect to this Agreement) (collectively,
“Losses”) incurred or suffered by any such person or entity directly arising from (i) any material breach by Lender of any of its representations or warranties contained in Section 8 or (ii) any material breach by
Lender of any of its covenants or agreements in this Agreement; provided, however, that Lender shall not be liable for any Losses arising from (A) any material breach by Borrower of any of its representations or warranties
contained in Section 8 or (B) any material breach by Borrower of any of its covenants or agreements in this Agreement. 
 (b) In
case any claim or litigation which might give rise to any obligation of Lender under this Section 14 (each an “Indemnifying Party”) shall come to the attention of the party seeking indemnification hereunder (the
“Indemnified Party”), the Indemnified Party shall within five Business Days notify the Indemnifying Party in writing of the existence and amount thereof; provided that the failure of the Indemnified Party to give such notice
shall not adversely affect the right of the Indemnified Party to indemnification under this Agreement, except to the extent the Indemnifying Party is materially prejudiced thereby. The Indemnifying Party shall promptly notify the Indemnified Party
in writing if it accepts such claim or litigation as being within its indemnification obligations under this Section 14. Such response shall be delivered no later than 45 days after the initial notification from the Indemnified Party;
provided that, if the Indemnifying Party reasonably cannot respond to such notice within 45 days, the Indemnifying Party shall respond to the Indemnified Party as soon thereafter as reasonably possible. 

(c) An Indemnifying Party shall be entitled to participate in and, if (i) in the good faith judgment of the Indemnified Party such claim
can properly be resolved by money damages alone and the Indemnifying Party has the financial resources to pay such damages and (ii) the Indemnifying Party admits that this indemnity fully covers the claim or litigation, the Indemnifying Party
shall be entitled to direct the defense of any claim at its expense, but such 

  
 17 








 
defense shall be conducted by legal counsel reasonably satisfactory to the Indemnified Party. An Indemnified Party shall not make any settlement of any claim or litigation under this
Section 14 without the written consent of the Indemnifying Party (such consent not to be unreasonably withheld or delayed). Nothing in this subsection (c) shall be deemed to limit, or be a waiver of either party in respect of, this
Section 14. 
 Section 15. Termination of Agreement. 

(a) This Agreement may be terminated (i) at any time by the written agreement of Lender and Borrower or (ii) by Lender (upon the
occurrence of a Default with respect to Borrower) or Borrower (upon the occurrence of a Default with respect to Lender). 
 (b) Unless
otherwise agreed by Borrower and Lender, the provisions of this Agreement shall survive the termination of this Agreement. 

Section 16. Amendments. No amendment or modification in respect of this Agreement shall be effective unless it shall be in
writing and signed by the parties hereto. 
 Section 17. Notices. 

(a) All notices and other communications hereunder shall be in writing and shall be deemed to have been duly given when received. 

(b) All such notices and other communications shall be directed to the following address: 

 

	 	(i)	If to Borrower to: 

  

	 	 	J.P. Morgan Securities LLC 


	 	 	EDG Marketing Support 


	 	 	Email: edg_notices@jpmorgan.com 


	 	 	edg.us.flow.corporates.mo@jpmorgan.com 


	 	 	Facsimile No: 1-866-886-4506 


 

	 	 	With a copy to: 

  

	 	 	Attention: Santosh Sreenivasan 


	 	 	Title: Managing Director 


	 	 	Telephone No: (212) 622-5604 


	 	 	Email: santosh.sreenivasan@jpmorgan.com 

  

	 	(ii)	If to Lender to: 

  

	 	 	Intrexon Corporation 


	 	 	20374 Seneca Meadows Parkway 


	 	 	Germantown, MD 20876 


	 	 	Attn: Donald P. Lehr 


	 	 	Telephone: (301) 556-9809 


	 	 	Email: dlehr@intrexon.com 


  
 18 









	 	(iii)	If to Collateral Agent to: 

  

	 	 	JPMorgan Chase Bank, National Association, New York Branch 


	 	 	EDG Marketing Support 


	 	 	Email: edg_notices@jpmorgan.com 


	 	 	edg.us.flow.corporates.mo@jpmorgan.com 


	 	 	Facsimile No: 1-866-886-4506 


 

	 	 	With a copy to: 

  

	 	 	Attention: Santosh Sreenivasan 


	 	 	Title: Managing Director 


	 	 	Telephone No: (212) 622-5604 


	 	 	Email: santosh.sreenivasan@jpmorgan.com 

 or, in the case of any party, at such other address as may be
designated by written notice to the other parties. 
 Section 18. Governing Law; Submission To Jurisdiction; Severability. 

(a) This Agreement shall be governed by and construed in accordance with the laws of the State of New York, but excluding any choice of law
provisions that would require the application of the laws of a jurisdiction other than New York. 
 (b) EACH PARTY HERETO IRREVOCABLY AND
UNCONDITIONALLY (A) SUBMITS TO THE NON-EXCLUSIVE JURISDICTION OF ANY UNITED STATES FEDERAL OR NEW YORK STATE COURT SITTING IN NEW YORK CITY, AND ANY APPELLATE COURT FROM ANY SUCH COURT, SOLELY FOR THE
PURPOSE OF ANY SUIT, ACTION OR PROCEEDING BROUGHT TO ENFORCE ITS OBLIGATIONS HEREUNDER OR RELATING IN ANY WAY TO THIS AGREEMENT OR THE LOAN HEREUNDER AND (B) WAIVES, TO THE FULLEST EXTENT IT MAY EFFECTIVELY DO SO, ANY DEFENSE OF AN INCONVENIENT
FORUM TO THE MAINTENANCE OF SUCH ACTION OR PROCEEDING IN ANY SUCH COURT AND ANY RIGHT OF JURISDICTION ON ACCOUNT OF ITS PLACE OF RESIDENCE OR DOMICILE. 

(c) EACH PARTY HERETO HEREBY IRREVOCABLY WAIVES ANY RIGHT THAT IT MAY HAVE TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM ARISING
OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY. 
 (d) To the extent permitted by law, the unenforceability or
invalidity of any provision or provisions of this Agreement shall not render any other provision or provisions herein contained unenforceable or invalid. 

(e) For purposes of the UCC, New York is the jurisdiction of the Collateral Agent in its capacity as securities intermediary with respect to
the Collateral and the Collateral Account. 

  
 19 








 Section 19. Counterparts. This Agreement may be executed in any number of
counterparts, and all such counterparts taken together shall be deemed to constitute one and the same agreement. 
 Section 20.
Designation of Replacement Collateral Agent. If at any time while this Agreement is in effect the Collateral Agent provides notice of its intention to resign as Collateral Agent hereunder, Lender shall be entitled to designate a bank or
trust company reasonably satisfactory to Borrower as a successor Collateral Agent. In the event of a designation of a successor Collateral Agent, each of the parties to this Agreement agrees to take all such actions as are reasonably necessary to
effect the transfer of rights and obligations of the departing Collateral Agent to such successor Collateral Agent, including the execution and delivery of amendments to this Agreement as shall be necessary to effect such designation and transfer.


  
 20 








 IN WITNESS WHEREOF, the parties hereto have executed this Share Lending Agreement as of the date
and year first above written. 
  

			
	 INTREXON CORPORATION,
 as
Lender

		
	By:	 	 /s/ Donald P. Lehr

		 	Donald P. Lehr
		 	Chief Legal Officer


 [Signature Page to Share Lending Agreement] 

  
 21 








 
			
	 J.P. MORGAN SECURITIES LLC,
 as
Borrower

		
	By:	 	 /s/ Kevin Cheng

		 	Name: Kevin Cheng
		 	Title: Vice President


 [Signature Page to Share Lending Agreement] 

  
 22 








 
			
	 JPMORGAN CHASE BANK, NATIONAL ASSOCIATION, NEW YORK BRANCH,

as Collateral Agent

		
	By:	 	 /s/ Kevin Cheng

		 	Name: Kevin Cheng
		 	Title: Vice President


 [Signature Page to Share Lending Agreement] 

  
 23 








 ANNEX A 

IMPORTANT RISK DISCLOSURES 

WITH RESPECT TO FULLY PAID OR 

EXCESS MARGIN SECURITIES 

LENDING TRANSACTIONS1 

Please read these important disclosures carefully before agreeing to lend any of your fully paid securities or excess margin securities (the “Loaned
Securities”) to J.P. Morgan Securities LLC (“we” or “JPMS”) pursuant to the Share Lending Agreement (the “SLA”) to which this Annex A is attached. These disclosures are intended to be read in conjunction with the
SLA between you and JPMS, which must be executed prior to entering into, and which governs, any loans of Loaned Securities to JPMS. These disclosures describe important characteristics of, and risks associated with engaging in, securities lending
transactions: 
  

	 	1.	THE PROVISIONS OF THE SECURITIES INVESTOR PROTECTION ACT OF 1970 (“SIPA”) MAY NOT PROTECT YOU WITH RESPECT TO LOANED SECURITIES AND, THEREFORE, THE COLLATERAL DELIVERED TO YOU MAY CONSTITUTE THE ONLY SOURCE
OF SATISFACTION OF JPMS’S OBLIGATIONS IN THE EVENT JPMS FAILS TO RETURN THE LOANED SECURITIES. 

  

	 	2.	Loss of Rights with Respect to Loaned Securities. While a securities loan is outstanding, and until Loaned Securities are credited back to your account upon termination of a loan, you will cease to own the Loaned
Securities and will not have the right to sell the Loaned Securities. However, you retain a contractual right to the return of the Loaned Securities and, accordingly, continue to have market exposure with respect to the Loaned Securities.


  

	 	3.	JPMS Compensation with Respect to Loaned Securities. JPMS and its associated persons will receive compensation in connection with the use of your Loaned Securities, including in connection with facilitating
settlement of short sales by JPMS, its affiliates and/or its customers. 

 The key factor in determining the amount of such
compensation JPMS and its associated persons will receive from using your Loaned Securities is the availability of the securities for lending in the marketplace relative to the demand to borrow such securities. JPMS has an opportunity to earn more
compensation when the securities become limited in supply relative to demand (i.e., become “hard to borrow” securities) 
  

	 	4.	Your Compensation with Respect to Loaned Securities. JPMS will not pay you any fee for the borrowing of the Loaned Securities. You have agreed to loan the Loaned Securities to JPMS in consideration of the
benefits you will receive in connection with the offer and sale of convertible notes for which JPMS is acting as underwriter. 


 

	1 	These disclosures are designed to satisfy the requirements of FINRA Rule 4330(b)(2)(B). 


  
 24 









	 	5.	Collateral for Loaned Securities. Pursuant to the SLA, in exchange for the Loaned Securities, JPMS will provide you (or, in the alternative, pledge to you in an account maintained by a custodian) with either cash
collateral or a form of non-cash collateral permissible under Rule 15c3-3(b)(3)(iii)(B) of the Securities Exchange Act of 1934 and related SEC guidance.


 Pursuant to the SLA and applicable regulations, JPMS will mark the Loaned Securities to market at the close of trading on
each business day and, if necessary, will transfer additional collateral no later than the close of business on the next business day so that the market value of the collateral is equal to the market value of the Loaned Securities. If JPMS defaults
and the market value of the Loaned Securities increases in value on the day JPMS defaults, the cash collateral provided by JPMS may be insufficient to fully collateralize the Loaned Securities. If JPMS collateralizes the Loaned Securities with
securities collateral, the securities collateral will be subject to market risk, and therefore may not be sufficient to replace the full value of Loaned Securities should JPMS default. 

SHOULD JPMS POST SECURITIES COLLATERAL AS PERMITTED BY APPLICABLE LAW, SOME SECURITIES PROVIDED BY JPMS AS COLLATERAL UNDER THE SLA MAY NOT BE
GUARANTEED BY THE UNITED STATES. 
  

	 	6.	Permitted Purpose to Borrow Loaned Securities. JPMS may borrow the Loaned Securities for any purpose permitted under Regulation T, including to make and facilitate short sales. Use of the Loaned Securities to
make or facilitate short sales could put downward pressure on the price of the Loaned Securities. 

  

	 	7.	“Hard to Borrow” Determination. Loaned Securities may be, or may become, “hard to borrow” because of short selling or scarcity of available lending supply or corporate events that may impact
liquidity in a security. 

  

	 	8.	Loaned Securities / Short Sales. You are under no obligation to enter into a securities loan with JPMS and may elect not to allow your Loaned Securities to be used in connection with short sales or any
other permitted purpose by not agreeing to enter into the SLA. 

  

	 	9.	Potential Tax Implication with Respect to Loaned Securities. During the term of any securities loan, you are entitled to receive the amount of all dividends and distributions made on or in respect of the Loaned
Securities. However, you will receive manufactured payments (e.g., cash substitute payments) in lieu of receiving dividends or distributions directly from the issuer (or in some cases involving non-cash
distributions, we may adjust the number of Loaned Shares to account for the value of the relevant distribution). Certain unique distributions may not be capable of being exactly replicated as a manufactured payment by JPMS. 


  
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 (a) Cash payments, and the fair value of
non-cash payments, in lieu of dividends may be taxable to you, and you may not be entitled to any exemption or preference with respect to these amounts. Adjustments to the number of Loaned Shares in lieu
of non-cash dividends could also be taxable to you. 
 (b) You should consult a tax
advisor regarding the tax implications of entering into a securities loan with JPMS, including, but not limited to: treatment of cash-in-lieu payments and adjustments to
the number of Loaned Shares under U.S. state tax laws and the Internal Revenue Code, as well as any foreign tax regulations and the treatment of interest received on cash collateral. 

 

	 	10.	JPMS Right to Terminate. JPMS shall have the right to terminate all or any portion of the securities loan at any time. In addition, JPMS shall have the right to liquidate the securities loan if a default, as
defined in the SLA, occurs with respect to you. A default includes, but is not limited to, if you: 

 (a) are
subject to certain voluntary or involuntary bankruptcy- or insolvency-related events; or 
 (b) fail to comply with your
obligation under the SLA to return collateral to JPMS when due; 
 (c) fail to provide any indemnity as required by the SLA;

 (d) notify JPMS of your inability or intention not to perform your obligations under the SLA; or 

(e) breach your representations and warranties or covenants in the SLA. 

  
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