**LICENSE      AGREEMENT**

**Effective      Day**
**Company**
**NTT**

**WHEREAS**
**Yissum      Agreement**
**Yissum**
**Ethosome**

**WHEREAS**

**WHEREAS**

**NOW      THEREFORE THE PARTIES DO HEREBY AGREE AS FOLLOWS:**

**Interpretation      and Definitions**

*vice-versa*

----

**Affiliate**

**Agreement**

**Company      Confidential Information**

**Development      Plan**

**Development      Results**

**Drug**

**Drug      Formulation**

**First      Commercial Sale**

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**Intellectual      Property Rights**

**Intercompany      Consideration"**

**License**

**Net      Sales**

**NTT      Confidential Information**

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**NTT      Formulation Technology**

**NTT      Patents**

**Party**
**Parties**

**Product**

**Regulatory      Approval**

**Reporting      Period**

**Resulting      Patents**

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**Sublicensee**

**Sub-License      Consideration**
**Intercompany      Consideration**

**Territory**

**Valid      Patent Claim**

**2.**
**Development      Plan**

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**Adverse      Experience**

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**Company's      Information**
**New      Company Information**

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**3.**
**Grant      of License by NTT**

**No      Implied Licenses**

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**4.**
**Consideration      and Reporting.**

| Milestone                                                                                                                                                                                                                                                                                                                        |   | Payment (in US Dollars) |
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|----------------------------------------|
|                                                                                                                                                                                                                                                                                                                             |   |                                   |
| Within 5 days                following the Effective Date                                                                                                                                                                                                                                                              |   | [***]                                  |
|                                                                                                                                                                                                                                                                                                                             |   |                                   |
| 90                days from the Effective Day                                                                                                                                                                                                                                                                                    |   | [***]                                  |
|                                                                                                                                                                                                                                                                                                                             |   |                                   |
| The                earliest of (a) within 30 days of the first enrollment in any country                of                the first patient in a Phase III clinical trial study (or equivalent                clinical program outside of the United States) or, (b) 36 months                from                Effective Day. |   | [***]                                  |
|                                                                                                                                                                                                                                                                                                                             |   |                                   |
| The                earliest of (a) Within 30 days of first received Regulatory Approval                or,                (b) 72 months form the effective day.                                                                                                                                                                  |   | [***]                                  |

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**Periodic      Report**
**Royalty      Period**

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**Auditing      Party**
**Audited      Party**

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**5.**
**Development      and Commercialization **

**6.      Ownership**

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**United      States Bankruptcy Code**
**Code**

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**7.**
**Confidentiality**

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**8.**
**Representations      Disclaimers and Warranties.**

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**8A.**
**Intellectual      Property.**

**Option**
**Prosecute**
**Prosecution**

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**9.**
**Liability,      Indemnity and Insurance**

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**10.**
**Termination      of the Agreement**

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**12.      Law**

**13.      Miscellaneous**

----

| NTT:                                                                                                    | Novel                Therapeutic Technologies Inc. |
|---------------------------------------------------------------------------------------------------------|----------------------------------------------------|
|                                                                                                    | POB                12006,                          |
|                                                                                                    | 7                Yad Harutzim                      |
|                                                                                                    | Herzliya                Pituach 46722              |
|                                                                                                    | ISRAEL                                             |
|                                                                                                    | Tel                - 972-9-961-2703                |
|                                                                                                    | Fax                - 972-9-961-2701                |
|                                                                                                    |                                               |
| Attention                Dan Touitou                                                                    |
|                                                                                                    |                                               |
| With                a copy to: Gross, Kleinhendler, Hodak, Berkman & Co. Law                Offices |
|                                                                                                    | One                Azrieli Center (Round Building) |
|                                                                                                    | Tel                Aviv 67021, Israel              |
|                                                                                                    | Tel:                +972-3-6074520                 |
|                                                                                                    | Fax:                +972-3-6074411                 |
|                                                                                                    |                                               |
|                                                                                                    | Attention:                Adv. Heather A. Stone    |
|                                                                                                    |                                               |
| The                Company:-                                                                            |
|                                                                                                    |                                               |
|                                                                                                    | Synvista                Therapeutics, Inc.         |
|                                                                                                    | 221                West Grand Avenue, Suite 200    |
|                                                                                                    | Montvale,                New Jersey 07645          |
|                                                                                                    | Tel:                201-818-5000                   |
|                                                                                                    | Fax:                201-934-8880                   |
|                                                                                                    |                                               |
|                                                                                                    | Attention:                Dr. Noah Berkowitz       |
| With                a copy to                                                                           |
|                                                                                                    |                                               |
|                                                                                                    | Pearl                Cohen Zedek Latzer, LLP       |
|                                                                                                    | 1500                Broadway, 12th Floor           |
|                                                                                                    | New                York, NY 10036                  |
|                                                                                                    | Tel:                646-878-0804                   |
|                                                                                                    | Fax:                646-878-0801                   |
|                                                                                                    |                                               |
|                                                                                                    | Attention:                Mark S. Cohen            |

----

| NTT    |                             |   | THE                COMPANY |
|--------|----------------------------------|--------|----------------------------|
|   |                             |   |                       |   |
| By:    | /s/                  Dan Touitou |   | By:                        | /s/              Noah Berkowitz |
|   |                             |   |                       |   |
| Name:  | Dan                Touitou       |   | Name:                      | Noah              Berkowitz, MD, PhD |
|   |                             |   |                       |   |
| Title: | CEO                              |   | Title:                     | President              & CEO |
|   |                             |   |                       |   |
| Date:  | January                20, 2008  |   | Date:                      | January                20, 2008 |

----

----

----

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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| **Provid                      Number** | **Lab                      Journal Reference** | **Molecular                      Formula** | **Molecular                      Weight** | **Structure** |
|----------------------------------------|------------------------------------------------|--------------------------------------------|-------------------------------------------|---------------|
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| [***]                                  | [***]                                          | [***]                                      | [***]                                     | [***]         |

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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
|                                 |                                         |                                     |                                    |          |
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|                                 |                                         |                                     |                                    |          |
| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
|                                 |                                         |                                     |                                    |          |
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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

----

| **Provid                        Number** | **Lab                        Journal Reference** | **Molecular                        Formula** | **Molecular                        Weight** | **Structure** |
|------------------------------------------|--------------------------------------------------|----------------------------------------------|---------------------------------------------|---------------|
|                                     |                                             |                                         |                                        |          |
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| [***]                                    | [***]                                            | [***]                                        | [***]                                       | [***]         |

----

| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

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| **Provid                    Number** | **Lab                    Journal Reference** | **Molecular                    Formula** | **Molecular                    Weight** | **Structure** |
|--------------------------------------|----------------------------------------------|------------------------------------------|-----------------------------------------|---------------|
|                                 |                                         |                                     |                                    |          |
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| [***]                                | [***]                                        | [***]                                    | [***]                                   | [***]         |

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