FOLPET –

Focus Meeting 

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Makhteshim Chemical Works

Ashland Inc

May 29 – EPA 
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Agenda

• Background and Introductions 

• Reg Review team

• Folpet Registrants and stakeholders 

• Adi Azmon – MCW

• Dr. Rob Everich – MANA

• Tom Keenan – Ashland Inc

• Ephi Gur - LSR

• Uses supported for reg review (MANA & Ashland) 

• Ag uses, labels, usage information including history 

• Description of non-food, industrial uses. Label usage information including use history 

• Global use of Folpet and the need for import tolerances 

• Anticipated data needs identified in work plan

• Review of studies submitted since docket has opened 

• Schedule for issuance of DCI

• Folpet label Amendments (avocadoes and hops) 

• Next steps
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Agricultural uses

Identification of uses to be supported through Reg 

Review

•Use on Hops to control downy mildew

• We agree to label changes reducing the 

maximum use rate 

•from 3.0 lb/product/A/app (2.4 lb ai)

• to 2.5 lb/product/A/app (2.0 lb ai)

• REI of 24 hrs to be retained

•Use on Avocado to control Scab (Sphaceloma)
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5

2002: Jim O’Brien elected Chairman 

and CEO

2008: Acquired Hercules 

Incorporated

2006: Divested Ashland Paving and 

Construction, Inc.

2011: Acquired 

International Specialty 

Products Inc. (ISP)

2011: Divested Ashland 

Distribution

2005: Sold stake in Marathon Oil 

joint venture

Our History
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Commercial 

Units

Ashland

Specialty

Ingredients

Ashland

Water

Technologies

Ashland

Performance

Materials

Ashland

Consumer 

Markets

Leading 

Products & 

Services

#1

cellulose ethers,

global leader in 

vinyl pyrrolidones

#1

specialty 

papermaking 

chemicals

#1

unsaturated 

polyester resins 

and vinyl ester 

resins

#2

U.S. franchised 

quick-lube chain, #3 

passenger-car 

motor oil

Sales1 $2.9 billion $1.7 billion $1.5 billion $2.0 billion

1 For 12 Months ended Dec. 31, 2012

Four Businesses
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Label Use Description

 Fungitrol 11 (95.9% Folpet)

 Powder

 For manufacturing use only in the formulation of fungicides for 

agricultural and industrial use

 Formulators are responsible for obtaining their own EPA registration 

of their formulated product

 Fungitrol 11-50S (48% Folpet)

 For industrial use

• Non-aqueous paints

• Coatings

• Caulking compounds

• Dosage levels of Fungitrol 11-50S between 1.0 – 3.0% by weight 

should be considered (0.48 – 1.44% a.i.)
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Folpet Global Status

• Folpet is a broad spectrum contact fungicide used 

world-wide in agriculture and as a biocide in paints, 

coatings, adhesives, wood and plastics as an anti fungal 

agent.

• Folpet is a multi-site active ingredient and has a major 

role in disease resistance management.

• Folpet is widely use in grapes, hops, fruit, vegetables 

and cereals in Europe and Latin America.

• Posted comments from stake holders in Colombia and 

Mexico stress the need to maintain all current import 

tolerances: apple, cranberry, cucumber, grape, raisin, lettuce, melon, onion (dry 

bulb), strawberry, and tomatoes)
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EU Status

• Folpet re-included into Annex I in 2007 and was 

recently re-registered in most of the EU member 

countries. 

•It is the primary choice as a partner to any new 

fungicide developed in Europe today. 

• MCW has over 18 Folpet different mixtures

• Syngenta, Bayer, BASF, DuPont (and others) hold 19 

additional mixtures

• During the re- registration process, Folpet MRLs were 

increased in garlic and tomatoes and were doubled in 

wine grapes.
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Rat 90 day inhalation 

Anticipated data gap 

• A guideline, GLP-compliant 28 day inhalation toxicity study 

will be submitted shortly.

• Results are “as expected” with clear NOAELs

• Systemic – 25 μg/L

• Portal of entry - 5 μg/L. 

• 90 day study for Captan provides additional relevant 

information.

• Based on the above a POD for RA can be set

• Use of additional animals for a 90-day inhalation toxicity 

study with Folpet is unethical given the available data.
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Other anticipated studies 

EFED response posted May 21

• Efate studies will be evaluated (Soil photolysis, Aerobic soil 

metabolism, Aerobic and Anaerobic Aquatic metabolism, 

ECM/ILV for soil and water) 

• Note EFED’s comment re Mesocosm study, Vegetative vigor 

and will review them in greater detail

• We will look into the PI fate data and find out if additional 

information exists. 

• Bird repro studies - we would like to confirm EEC’s. 

• EFED uses default foliar 1⁄2-life of 35 days where in the past used 

2.55 days.

• Using old GAP a maximum EEC of 736 ppm on short grass 

food items (worst case) is calculated.

• Avian Inhalation – non guideline study 
FOLPAN 80WDG Label Changes

Hops: Downy Mildew 

- Apply 3 2.5 pounds of Folpan 80 WDG per acre by ground.

- Do not apply more than 12 10 pounds of Folpan 80 WDG per acre 

per year.

 - Do not enter or allow worker entry into treated areas during the 

restricted-entry interval (REI) of 24 hours. (no change)

Avocado: Scab (Sphaceloma)

- Do not make applications within 1 7 days of harvest.

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Next steps