log Fish BCF = 3.98 (E)

log Fish BAF = 6.52 (E) 

POTW removal (%) = 90 via sorption; OECD 301D(Closed Btl): 

 

Time for complete ultimate aerobic biodeg > mo

Sorption to soils/sediments = v.strong

PBT Potential: P3B2

*CEB FATE: Migration to ground water = negl

 Health:

 Health Summary: Absorption of the neat material is nil through the skin, 

poor through the skin when in solution, poor from the lung and GI tract (pchem). Concern for 

respiratory sensitization, mutagenicity, developmental toxicity, male reproductive, liver, kidney 

toxicity and marginal concern for oncogenicity based on the epoxides. Concern for respiratory 

irritation based on information in MSDS

 Test Data: (-) Salmonella with and without activation; (-) E. coli 

with and without activation; rat oral LD0 = 2500 mg/kg; rat dermal LD0 = 2500 mg/kg; no eye 

irritation in rabbits; no skin irritation in rabbits; no skin sensitization in guinea pigs using the 

Magnusson-Kligman assay; rat 28-day oral NOEL = 1000 mg/kg (highest dose tested)

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 *

daphnid 48-h LC50 *

green algal 96-h EC50 *

fish _ chronic value 0.001

daphnid _ chronic 

value

0.002

algal _ chronic 

value

0.035 Using Baseline 

Toxicity Values in the 

Absence of a QSAR.

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for Polyepoxides; SAR chemical 

class = epoxides-poly; MW 593; solid with mp = 39-46 C (M); log Kow = 7.3 (P); S = 0.063 

mg/L at 20 C (M); pH7; effective concentrations based on 100% active ingredients and mean 

measured concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Ecotoxicity Test Data Results
P-15-0356 (Oxirane, 2,2'-[[1-[4-[1-methyl-1-[4-(2-oxiranylmethoxy)phenyl]ethyl]phenyl]

ethylidene]bis(4,1-phenyleneoxymethylene)]bis- and 2-Propanol, 

1,3-bis[4-[1-[4-[1-methyl-1-[4-(2-oxiranylmethoxy)phenyl]ethyl]phenyl]-1-[4-(2-oxiranylmetho

xy)phenyl]ethyl]phenoxy]-)

CAS RN: 115254-47-2 and 180063-56-3

Trade Name: TECHMORE VG3101L, VG3101L, PAEX (2nd chemical)

The PMN product is a "one pot mixture" consisting of two substances, CASRNs 115254-47-2 

and 180063-56-3. The aquatic studies submitted for this PMN were previously submitted and 

reviewed under and . The ecotoxicity review for is 

provided below. 

Two ecotoxicity studies were submitted with the from 

 a 96-hour acute fish test and a 48-hour acute daphnid immobilization test. The 

studies were conducted in 1993 and the substance was described as light yellow solid with the 

water solubility of 63.4 μg/L, a mixture of 

7,7,8-tris-[4-(2,3-epoxy-propoxyphenyl)]-7-methyl-p-cymene and its dimer (PAEX) with no 

reported ratios and purity. Both studies were conducted by the 

 under GLP conditions with a certificate of 

analysis and a signed quality assurance statement also provided. The actual concentrations in the 

test solution were determined by HPLC (level of detection not reported). The studies complied 

with OECD guidelines 301 D and 202 (Daphnia sp., Acute Immobilization Test And 

Reproduction Test), and EC guidelines C.1 and 2., published in the Official Journal of the 

European Communities L 383 A dated December 29th, 1992. The tests followed the OECD test 

guidelines for 1) O2, pH, and temperature; 2) species, age, number of organisms per replicate 

and 4) appropriate response in controls. 

Fish Ecotoxicity Test:

The 96-hour acute toxicity test for Gold orfe (Leuciscus idus) (10 fish/ concentration) was a limit 

test conducted under semi-static conditions (daily renewal), using a nominal concentration of 

100mg/L. A control and a vehicle control (100 mg Tween 80/L) were also run. The test solution 

was prepared by suspending the test substance in 100 mg Tween 80 using a mortar and pestle, 

then mixing with 100 mL water, followed by sonication for 15 minutes. The volume was made 

up to 1000 mL with water. Water quality parameters were the following: temperature = 

20.0-20.5°C, pH = 6.80-7.71, and DO = 62.0%-99.6%. No mortality or behavioral changes were 

observed. The actual concentrations in the test solution were determined by HPLC. The 

analytical concentration in the test solution was 0.97 mg/L.

96-hour LC50 > 0.97 mg/L (analytical concentration)

NOEC = 0.97 mg/L (analytical concentration)

Invertebrate Ecotoxicity Test:

The 48-hour acute toxicity test for D. magna (four replicates per test concentration/ 5 daphnids 

per replicate) was a limit test conducted under semi-static conditions with daily renewal, using a 

nominal concentration of 100 mg/L. A control and a vehicle control (100 mg Tween 80/L) were 

also run. The test solution was prepared by suspending the test substance in 100 mg Tween 80 

using a mortar and pestle, then mixing with 100 mL water, followed by sonication for 15 
minutes. The volume was made up to 1000 mL with water. Water quality parameters were the 

following: temperature = 20±1°C, pH = 7.65-7.96, and DO = 94.1%-99.0%. No mortality, 

immobilization or other indications of toxic effects were observed in D. magna. The actual 

concentrations in the test solution were determined by HPLC. The analytical concentration in 

the test solution was 0.84 mg/L. 

48-hour EC50 > 0.84 mg/L (analytical concentration)

NOEC = 0.84 mg/L (analytical concentration)

Both tests are considered invalid. There is no information on purity or the ratios of the mixture 

for the test substance. Also, the carrier, Tween 80, is an emulsifier and should not have been 

used as a vehicle, since this is not one of the recommended carriers. In addition, for this 

polyepoxide, the concern is for chronic, not acute, therefore predicted values from ECOSAR (v. 

1.00a) will be used to determine risk for under the chemical class of polyepoxides. 

The most appropriate and environmentally protective value used to determine the chronic 

concern concentration is the ChV for fish as 0.001 mg/L. This value is already the most 

conservative without an assessment (uncertainty) factor of 10, to yield 0.001 mg/L or 1 ìg/L.

Chronic Concern Concentration = 1 ppb.

To address the acute concern concentration, based on a log Kow of 7.29 (EPI) and predicted 

water solubility of 0.003 mg/L at 25oC, acute concern concentrations are predicted to be no 

effects at saturation.

Acute Concern Concentration = no effects at saturation.

Ecotox Reviewer: 

Date: April 9, 2015

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb) 

Acute 

Concentration of Concern 

(ppb) Chronic

1

SARs Epoxides

SAR Class Epoxides-Poly

New Chemcial Category Epoxides

Ecotox Factors Comments: 

 SAT Chair: