Support Documents for 

Significant New Use Rules (SNURs) on 

Premanufacture Notices (PMNs) 

P-09-589 and P-09-590 

EPA Docket EPA-HQ-OPPT-2010-1075 

 

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Index

A-001 Structure Activity Team (SAT) Reports for 

PMNs P-09-589 and P-09-590 

A-002 Initial Review Engineering Reports for 

PMNs P-09-589 and P-09-590 

A-003 Initial Review Exposure Reports for 

PMNs P-09-589 and P-09-590 

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A-001 

Structure Activity Team (SAT) Reports 

for PMNs P-09-589 and P-09-590 

 

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SAT Report

PMN Number: P-09-0589

SAT Date: 9/1/2009

Related cases:

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 2-3 3 Health: PMN ; Eco: 

2-3 Health: Hydrol Pdt ; Eco: 

 Persistence Bioaccum Toxicity Comments

 1 1 3 PMN substance

 2 1 3

Exposure Based Review:

Health: No

Ecotox: No

Routes of exposure: Health: Dermal Drinking Water Inhalation 

Ecotox: All releases to water

Fate: ; PMN negl; Hyd Pdt apid; Hyd Pdt 

rapid

P2Rec Comments:

Comment: No Comment

Keywords:

 Keywords: 

IRR/CORR-E,S,L,MM

ACUTE

REPRO

MUTA

ONCO

BLOOD

SENS-S

SYSTOX: SPLEEN, LIVER, BONE

KIDNEY

NEURO (CNS)

DEVEL

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AQUATOX-A,C

Summary of Assessment:

 Fate:

Fate Summary: P-09-0589

FATE: Estimations for hydrolysis product MW 87 

log Kow = 0.63 (M)

log Koc = 2.06 (E)

log Fish BCF = 0.50 (E)

log Fish BAF = 0.074 (E)

FATE: Estimations for hydrolysis product MW 104 

log Kow = -0.05 (E)

log Koc = 1.94 (E)

log Fish BCF = 0.50 (E)

log Fish BAF = -0.019 (E)

PMN Substance: Liquid with MP = -40 EC (M)

S = Reacts

Hydrolysis Half-life = min - hr

VP = 1.1E-2 torr at 25 EC (E)

BP = 266 EC (E)

H < 1.00E-8 (E)

POTW removal (%) = via hydrolysis; then Hyd Pdt 15 via biodeg; 

Hyd Pdt 0. 

Time for complete ultimate aerobic biodeg = Hyd Pdt Hyd Pdt mo

Sorption to soils/sediments = Hyt Pdt low; Hyd Pdt low.

PBT Potential: PMN P1B1; Hyd Pdt P2B1; Hyd Pdt P2B1.

*CEB FATE: Migration to ground water = PMN negl;Hyd Pdt rapid; Hyd Pdt 

rapid. 

 Health:

 Health Summary: Absorbed with reaction all routes, based on 

physical/chemical properties. There are concerns for; irritation/corrosion to all exposed tissues; 

dermal sensitization; acute toxicity; systemic effects to the spleen, liver, and bone marrow; 

kidney toxicity; neurotoxicity (i.e., effects to the central nervous system); reproductive toxicity; 

blood toxicity; mutagenicity; oncogenicity; and developmental toxicity, based on test data for 

analogs.

 Test Data: Submitted with the PMN 

the major component 

Negative in the Ames assay, with and without activation;

Negative for chromosome abberation in CHO cells, with and without activation;

Rat acute oral toxicity LD50 2.52 g/kg;

Moderate eye irritant (species unspecified);

Slight skin irritant in rabbits;

Rat repeated dose (28D) oral reproductive toxicity NOAEL 250 mg/kg;

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Rat repeated dose (28D) oral toxicity NOAEL 10 mg/kg, with effects to the blood, spleen, liver, 

and bone marrow

Submitted with 

Moderate skin irritant in rabbits;

Moderate to severe eye irritant in rabbits;

Adverse acute effects to the blood, bone marrow, spleen, and nervous system in rats (single oral 

dose 1.46 g/kg, 15-day study);

Moderate dermal sensitizer in female guinea pigs (4/15 showed positive reaction);

Dermal irritant in guinea pigs;

Submitted with :

Ames assay negative with and without activation;

Chromosome aberration in human peripheral blood lymphocytes negative with and without

activation;

Not a skin sensitizer in male guinea pigs;

Rat repeated dose (28D) oral(gavage) toxicity NOAEL 15 mg/kg, with reversible effects to the 

blood, spleen, liver, and kidney 

Submitted with :

Moderate skin irritant in rabbits;

Adverse acute effects to the blood, bone marrow, spleen, and nervous system in rats (single oral 

dose 1.46 g/kg, 15-day study), acute oral (gavage) LD50 > 1.46 g/kg;

Not a dermal sensitizer in female guinea pigs (4/15 showed equivocal response)

Submitted with (most data for ):

Ames assay negative with and without activation;

Chromosome aberration in human peripheral blood lymphocytes negative with activation and

positive without activation (at highest dose, at 44 hrs);

Corrosive to rabbit eyes;

Mild skin irritant in rabbits;

Skin sensitizer in guinea pigs (M&K); equivocal in Buehler test;

Rat acute oral LD50 2.3 g/kg;

Mouse acute oral LD50 1.0 g/kg;

Repeated dose oral (gavage) toxicity LOEL 10-25 mg/kg, with effects to the blood, spleen, liver, 

and kidney;

Rat acute neurotoxicity LOEL 300 mg/kg, with NOEL 100 mg/kg;

Rat subchronic (13 wk) neurotoxicity LOEL 400 mg/kg, with NOEL 124 mg/kg;

Rat oral (gavage) developmental toxicity NOAEL 600 mg/kg (highest dose tested), with no 

maternal toxicity NOAEL;

Rabbit oral (gavage) developmental toxicity LOAEL 24 mg/kg, with NOAEL 14 mg/kg, and 

with no maternal toxicity NOAEL ;

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Rat two-generation oral (gavage) reproductive toxicity LOAEL 10 mg/kg (lowest dose tested);

Induces liver tumors

Submitted with :

 Ames assay negative with and without activation;

Sister chromatid exchange in CHO cells positive with activation (weak response), negative 

without activation;

Severe eye irritant (species not specified);

Corrosive to rabbit skin;

Extreme skin sensitizer in guinea pigs;

Rat acute oral LD50 2.0-3.0 g/kg;

Rabbit acute dermal LD50 0.5-2.0 g/kg;

Rat (M) oral (gavage) reproductive toxicity LOAEL 186 mg/kg (single dose)

 Ecotox:

Test 

Organism

Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 33

daphnid 48-h LC50 3.1

green algal 96-h EC50 1.2

fish chronic value 0.55

daphnid _ chronic value 0.015

algal _ chronic value 0.52

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for for the 

hydrolysis products; SAR chemical class = (hydrolysis product); MW 242; liquid (P); 

log Kow = 1.69 (EPI, hydrolysis product); pH7; effective concentrations based on 100% active 

ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3; and TOC 

<2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

2

SARs

SAR Class

Ecotox Factors Comments: 

 SAT Chair: J. Kwiat

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SAT Report

PMN Number: P-09-0590

SAT Date: 9/1/2009

Related cases:

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 2-3 3 Health: PMN ; Eco: 

2-3 Health: Hydrol Pdt ; Eco: 

 Persistence Bioaccum Toxicity Comments

 1 1 3 PMN substance

 2 1 3

Exposure Based Review:

Health: No

Ecotox: No

Routes of exposure: Health: Dermal Drinking Water Inhalation 

Ecotox: All releases to water

Fate: ; PMN negl; Hyd Pdt rapid; Hyd Pdt 

rapid

P2Rec Comments:

Comment: No Comment

Keywords:

 Keywords: 

IRR/CORR-E,S,L,MM

ACUTE

REPRO

ONCO

BLOOD

SENS-S

SYSTOX: SPLEEN, LIVER, BONE

KIDNEY

NEURO (CNS)

DEVEL

AQUATOX-A,C

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Summary of Assessment:

 Fate:

Fate Summary: P-09-0590

FATE: Estimations for hydrolysis product MW 87 

log Kow = 0.63 (M)

log Koc = 2.06 (E)

log Fish BCF = 0.50 (E)

log Fish BAF = 0.074 (E)

FATE: Estimations for hydrolysis product MW 92 

log Kow = -0.41 (E)

log Koc = 1.64 (E)

log Fish BCF = 0.50 (E)

log Fish BAF = -0.037 (E)

PMN Substance: Liquid with MP < -25 EC (M)

S = Reacts

Hydrolysis Half-life = min - hr

VP = 0.17 torr at 25 EC (NOMO5)

BP = 213 EC (NOMO5) based on 59 EC @ 1.5 mm Hg (M)

H < 1.00E-8 (E)

POTW removal (%) = via hydrolysis; then Hyd Pdt 15 via biodeg; 

Hyd Pdt 0. 

Time for complete ultimate aerobic biodeg = Hyd Pdt mo; Hyd Pdt mo

Sorption to soils/sediments = Hyt Pdt low; Hyd Pdt low.

PBT Potential: PMN P1B1; Hyd Pdt P2B1; Hyd Pdt P2B1.

*CEB FATE: Migration to ground water = PMN negl;Hyd Pdt rapid; Hyd Pdt 

 rapid. 

 Health:

 Health Summary: 

Absorbed with reaction all routes, based on physical/chemical properties. There are concerns 

for; irritation/corrosion to all exposed tissues; dermal sensitization; acute toxicity; systemic 

effects to the spleen, liver, and bone marrow; kidney toxicity; neurotoxicity (i.e., effects to the 

central nervous system); reproductive toxicity; blood toxicity; oncogenicity; and developmental 

toxicity, based on test data for analogs.

 Test Data: Submitted with the PMN (analog data, 

the major component ):

Negative in the Ames assay, with and without activation;

Negative for chromosome abberation in CHO cells, with and without activation;

Rat acute oral toxicity LD50 2.52 g/kg;

Moderate eye irritant (species unspecified);

Slight skin irritant in rabbits;

Rat repeated dose (28D) oral reproductive toxicity NOAEL 250 mg/kg;

Rat repeated dose (28D) oral toxicity NOAEL 10 mg/kg, with effects to the blood, spleen, liver, 

and bone marrow

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Submitted with (most data for ):

Ames assay negative with and without activation;

Chromosome aberration in human peripheral blood lymphocytes negative with activation and

positive without activation (at highest dose, at 44 hrs);

Corrosive to rabbit eyes;

Mild skin irritant in rabbits;

Skin sensitizer in guinea pigs (M&K); equivocal in Buehler test;

Rat acute oral LD50 2.3 g/kg;

Mouse acute oral LD50 1.0 g/kg;

Repeated dose oral (gavage) toxicity LOEL 10-25 mg/kg, with effects to the blood, spleen, liver, 

and kidney;

Rat acute neurotoxicity LOEL 300 mg/kg, with NOEL 100 mg/kg;

Rat subchronic (13 wk) neurotoxicity LOEL 400 mg/kg, with NOEL 124 mg/kg;

Rat oral (gavage) developmental toxicity NOAEL 600 mg/kg (highest dose tested), with no 

maternal toxicity NOAEL;

Rabbit oral (gavage) developmental toxicity LOAEL 24 mg/kg, with NOAEL 14 mg/kg, and 

with no maternal toxicity NOAEL ;

Rat two-generation oral (gavage) reproductive toxicity LOAEL 10 mg/kg (lowest dose tested);

Induces liver tumors

Submitted with :

 Ames assay negative with and without activation;

Sister chromatid exchange in CHO cells positive with activation (weak response), negative 

without activation;

Severe eye irritant (species not specified);

Corrosive to rabbit skin;

Extreme skin sensitizer in guinea pigs;

Rat acute oral LD50 2.0-3.0 g/kg;

Rabbit acute dermal LD50 0.5-2.0 g/kg;

Rat (M) oral (gavage) reproductive toxicity LOAEL 186 mg/kg (single dose)

 Ecotox:

Test 

Organism

Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 31

daphnid 48-h LC50 2.9

green algal 96-h EC50 1.1

fish _ chronic value 0.52

daphnid chronic value 0.015

algal _ chronic value 0.49

Sewage Sludge 3-h EC50 _

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Sewage Sludge _ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for for the 

hydrolysis products; SAR chemical class = (hydrolysis product); MW 230; liquid (P); 

log Kow = 1.69 (EPI, hydrolysis product); pH7; effective concentrations based on 100% active 

ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3; and TOC 

<2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

2

SARs

SAR Class

Ecotox Factors Comments: 

 SAT Chair: J. Kwiat

EPA SANITIZED Page 11 of 55
A-002 

Initial Review Engineering Reports 

 for PMNs P-09-589 and P-09-590 

 

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INITIAL REVIEW ENGINEERING REPORT

P-09-0589

Focus Ready Draft 9/14/2009

ENGINEER: El-Zoobi \ AG

PV (kg/yr): 

Revision Notes/Assessment Overview:

SUBMITTER:

 

 

Consumer Use:

SAT (concerns): (9/1/2009):

Related Cases and Misc SAT Info:

Migration to groundwater:

PBT rating: P2 B1 T3 PMN: Health 2-3; Eco 3 // Hydrolysis Product: Health 2-3 /// PMN: P1B1T3 // 

: P2B1T3

Health: 2-3, Dermal, Drinking Water, Inhalation

Eco: 3, Water (All releases to water with a CC = 2 ppb)

OCCUPATIONAL EXPOSURE RATING: 2B

NOTES & KEY ASSUMPTIONS:

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Generated by the 06/07/2005 version of ChemSTEER. 

POLLUTION PREVENTION CONSIDERATIONS:

 

P2 REC:

EXPOSURE-BASED REVIEW: 

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P-09-0589

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P-09-0589

 

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INITIAL REVIEW ENGINEERING REPORT

P-09-0590

Focus Ready Draft 9/14/2009

ENGINEER: El-Zoobi \ AG

PV (kg/yr): 

Revision Notes/Assessment Overview:

SUBMITTER:

USE:

 

 

 

Consumer Use: No

SAT (concerns): (9/1/2009):

Related Cases and Misc SAT Info:

Migration to groundwater:

PBT rating: P2 B1 T3 PMN: Health 2-3; Eco 3 // Hydrolysis Product: Health 2-3 /// PMN: P1B1T3 // 

: P2B1T3

Health: 2-3, Dermal, Drinking Water, Inhalation

Eco: 3, Water (All releases to water with a CC = 2 ppb)

OCCUPATIONAL EXPOSURE RATING: 2-3B

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NOTES & KEY ASSUMPTIONS:

Generated by the 06/07/2005 version of ChemSTEER. 

POLLUTION PREVENTION CONSIDERATIONS:

 

P2 REC:

EXPOSURE-BASED REVIEW: 

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P-09-0590

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P-09-0590

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STANDARD REVIEW ENGINEERING REPORT

P-09-0589

Standard Review Draft 11/10/2009

ENGINEER: El-Zoobi \ AG

PV (kg/yr): 

 

 

SUBMITTER:

USE:

 

 

 

SAT (concerns): (9/1/2009):

Related Cases and Misc SAT Info:

Migration to groundwater:

PBT rating: P2 B1 T3 PMN: Health 2-3; Eco 3 // Hydrolysis Product: Health 2-3 /// PMN: P1B1T3 // 

EPA SANITIZED Page 27 of 55
: P2B1T3

Health: 2-3, Dermal, Drinking Water, Inhalation

Eco: 3, Water (All releases to water with a CC = 2 ppb)

OCCUPATIONAL EXPOSURE RATING: 1-2B

NOTES & KEY ASSUMPTIONS:

Generated by the 06/07/2005 version of ChemSTEER. 

POLLUTION PREVENTION CONSIDERATIONS:

P2 REC:

EXPOSURE-BASED REVIEW: No 

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P-09-0589

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P-09-0589

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STANDARD REVIEW ENGINEERING REPORT

P-09-0590

Standard Review Draft 11/25/2009

ENGINEER: El-Zoobi \ AG

PV (kg/yr): 

 

 

SUBMITTER:

USE:

 

 

 

Consumer Use:

SAT (concerns): (9/1/2009):

Related Cases and Misc SAT Info:

Migration to groundwater: Other (please specify)

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PBT rating: P2 B1 T3 PMN: Health 2-3; Eco 3 // Hydrolysis Product: Health 2-3 /// PMN: P1B1T3 // 

: P2B1T3

Health: 2-3, Dermal, Drinking Water, Inhalation

Eco: 3, Water (All releases to water with a CC = 2 ppb)

OCCUPATIONAL EXPOSURE RATING: 2B

NOTES & KEY ASSUMPTIONS:

Generated by the 06/07/2005 version of ChemSTEER. 

 

 

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P-09-0590

 

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P-09-0590

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A-003 

Initial Review Exposure Reports 

 for PMNs P-09-589 and P-09-590 

 

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September 11, 2009 page of 

INITIAL REVIEW EXPOSURE REPORT (IRExR) 

 Chemical ID: P090590 Reviewer: Sherer 

 

Results Table: Dose, Concentration, and Days Exceeded Results Summary 

Exposure Scenario1 Water Landfill Stack Air Fugitive Air 

Drinking Water Fish Ingestion 

ADR LADD ADR LADD 

7Q104 

CC=2 

PDM 

Days 

Exceeded

LADD ADR LADD ADR LADD 

Release activity(ies)2; 

exposure 

calculation(s)3

mg/kg/day mg/kg/day mg/kg/day mg/kg/day μg/l # Days mg/kg/day mg/kg/day mg/kg/day mg/kg/day mg/kg/day 

max LADD --- --- --- --- --- --- 1.79e-04 --- --- --- --- 

max ADR, max 

Acute Eco, PDM, max 

LADD 

5.17e-03 2 31e-05 6.13e-05 3.13e-07 113.21 85 --- --- --- --- --- 

 

1

 Exposure scenario titles consist of release activity followed by exposure calculation abbreviation. 2 Release activities are from engineering report's Manufacturing (Mfg), Processing (Proc) and Use release activity 

labels. 

Multiple release activities are combined in one exposure scenario if their releases occur at same location. 3

 Exposure calculations are Acute Dose Rate (ADR), Lifetime Average Daily Dose (LADD), and Probabilistic 

Dilution Model (PDM). There may be one, two, or all three exposure calculations per exposure scenario. 

CC is the aquatic concentration of concern. 

4

 This column displays concentration values for the 7Q10 streamflow, which is defined as the average streamflow of 

the 7 consecutive days of lowest flow within a 10 year period. 

Remarks: 

Fate test recommendations?: (default is NA) 

EPA SANITIZED Page 49 of 55
September 11, 2009 page of 

 INITIAL REVIEW EXPOSURE REPORT 

Chemical ID: P090590 Assessor: Sherer 

ENVIRONMENTAL RELEASES 

 Scenario#:1 Number of Release Sites: 

 Release Activity: max LADD 

 Release Description: WATER LANDFILL 

Non-sludge/Sludge 

STACK FUGITIVE 

Total Releases: 

 (kg/yr) (kg/yr) (kg/yr) (kg/yr) 

 

 Non-sludge/Sludge 

Release Days/yr: 

Per Site Release: 

 (kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day) 

Remarks: 

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September 11, 2009 page of 

INITIAL EXPOSURE REVIEW REPORT 

Chemical ID: P090590 

DRINKING WATER EXPOSURE ESTIMATES FROM LANDFILL RELEASES 

SCENARIO #: 1 ACTIVITY: - max LADD 

RELEASE DESCRIPTION: 

EXPOSED POPULATION: Adult 

NUMBER 

OF 

SITES 

NON-SLUDGE 

LANDFILL 

RELEASE AND 

DAYS OF 

RELEASE 

(kg/site/day)/(days) 

 LANDFILLED 

SLUDGE1 

AND DAYS OF 

RELEASE 

(kg/site/day)/(days)

MIGRATION 

DESCRIPTOR2

ADSORPTION 

TO 

WASTEWATER 

SLUDGE 

 (%) 

DRINKING 

WATER 

TREATMENT 

 (%) 

 

 1 Landfilled sludge equals the fraction adsorbed to wastewater treatment sludge times the surface 

 water pre-treatment release.

 

 2 Migration Descriptor Log Koc Groundwater Concentration (GWC) 

 (mg/L per kg release)

 Negligible no migration None 

Negligible to slow > 4.5 3.21E-6 

Slow <4.5 to 3.5 2.67E-5 

Moderate <3.5 to 2.5 5.95E-5 

Rapid <2.5 7.55E-5 

 

ASSUMPTIONS 

 Exposure Units Results ED 

(years) 

AT 

(years) 

BW 

(kg) 

IR 

 (L/day) 

Cancer 

LADDpot (mg/kg/day) 1.79E-04 30.00 75.00 71.80 1.40 

LADCpot (mg/L) 9.18E-03 30.00 75.00 NA NA 

REMARKS: 

 

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September 11, 2009 page of 

 INITIAL REVIEW EXPOSURE REPORT 

Chemical ID: P090590 Assessor: 

ENVIRONMENTAL RELEASES 

 Scenario#:2 Number of Release Sites: 

 Release Activity: - max ADR, max acute eco, PDM, max LADD 

 Release Description: WATER LANDFILL 

Non-sludge/Sludge 

STACK FUGITIVE 

Total Releases: 

 (kg/yr) (kg/yr) (kg/yr) (kg/yr) 

 

 Non-sludge/Sludge 

Release Days/yr: 

Per Site Release: 

 (kg/site/day) (kg/site/day) (kg/site/day) (kg/site/day) 

Remarks: 

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INITIAL REVIEW EXPOSURE REPORT 

 Chemical ID: P090590 

SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES 

SCENARIO #: 2 Number of Sites: RELEASE ACTIVITY max 

ADR, max acute eco, PDM, max 

LADD 

SIC-CODE DESCRIPTION: POTW's (All facilities) 

SIC-CODE (S): 4952 EXPOSED POPULATION: Adult 

WWT 

REMOVAL 

(%) 

RELEASE 

DAYS 

PRETREATMENT 

RELEASE 

(kg/site/day) 

POSTTREATMENT 

RELEASE 

(kg/site/day) 

DWT 

(%) BCF 

(L/kg) 

 

AQUATIC EXPOSURE ESTIMATES - SURFACE WATER 

PLANT 

TYPE 

% ILE 

FACILITY 

STREAM FLOW (MLD) STREAM CONC. (μg/l) 

Harmonic 

Mean 30Q5 7Q10 1Q10 

Harmonic 

Mean 30Q5 7Q10 1Q10 

ALL 50 125.56 44.02 26.80 22.53 0.96 2.73 4.48 5.33 

ALL 10 11.11 1.94 1.06 0.96 10.80 61.86 113.21 125.00 

DRINKING WATER AND FISH INGESTION EXPOSURE ESTIMATES 

Exposure Units 

Drinking Water Results Drinking 

Water Units Fish Ingestion Results 

Fish 

Ingestion 

Units 

50% 10% 50% 10% 

Cancer 

LADDpot 2.04E-06 2.31E-05 mg/kg/day 2.77E-08 3.13E-07 mg/kg/day 

LADCpot 1.05E-04 1.18E-03 mg/L 3.31E-04 3.74E-03 mg/kg 

Acute 

ADRpot 2.28E-04 5.17E-03 mg/kg/day 5.43E-06 6.13E-05 mg/kg/day 

SIC Code Comments: 

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September 11, 2009 page of 

INITIAL REVIEW EXPOSURE REPORT 

 Chemical ID: P090590 

SIC CODE EXPOSURES TO SURFACE WATER RELEASES 

SCENARIO #: 2 RELEASE ACTIVITY: max ADR, max acute eco, PDM, max 

LADD 

SIC CODE DESCRIPTION: POTW's (All facilities) 

ASSOCIATED SIC CODES: 4952 

SIC CODE RESULTS 

COC (μg/L) 

Percent of 

Year COC 

Exceeded 

Number of 

Days COC 

Exceeded 

Release 

days/year 

Loading 

(kg/site/day) 

Waste Water 

Treatment (%) 

High/Avg 

Analysis 

2.00 23 85 High 

Remark: COC is exceeded more than 20 days/year. 

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September 11, 2009 page of 

LEGEND FOR NEW CHEMICALS EXPOSURE REPORT 

This new chemicals exposure report was prepared by the Exposure Assessment Branch (EAB) of the Economics, 

Exposure and Technology Division, Office of Pollution Prevention and Toxics, USEPA. 

The goals of these reports are to calculate conservative (protective) estimates of exposure endpoints for consumers, 

the general population, and the environment. 

For each exposure scenario to industrial releases, the following three endpoints are calculated: 

(1) maximum possible acute concentrations and doses 

(2) maximum possible chronic concentrations and doses 

(3) for water releases ≥ 20 days, the probability of exceedence of the aquatic concentration of concern 

These endpoints are identified by abbreviations on the Release Activity line, e.g., (1) max ADR, (2) max 

LADD, (3) max PDM. Depending on the release inputs, these endpoints may be calculated and presented on 

the same page or different pages. That is, a release activity ID of mfg; max ADR, max PDM, max LADD

indicates that all the exposure endpoints were calculated from common manufacturing release values; 

conversely, a release activity ID of mfg &proc; max ADR indicates that only the maximum acute exposure 

values were calculated for manufacturing and processing releases that occurred at the same site. 

For each consumer product use exposure scenario, whether exposure is to the user directly or to the general 

population/environment, the maximum exposure values are calculated and presented together. 

In addition to the exposure values above, EPA policy directs that exposure and release values be compared to 

criteria threshold values for Exposure-based and PBT Exposure-based cases. 

Exposure-based (YX) cases (those with ≥ 100,000 kg/yr production volume) 

Criteria are exceeded under the following conditions: 

 Presence in consumer product with likely exposure 

≥ 3E-3 mg/kg/d exposure via air, fish ingestion or drinking water 

≥ 10,000 kg/yr release to environment (post-treatment) 

≥ 1,000 kg/yr release to water (post-treatment) 

Persistent, Bioaccumulative, Toxic (PBT) chemicals of P2B2 rating or higher and production volume ≥ 20,000 kg/yr 

Criteria are exceeded as for YX cases, with the following differences: 

≥ 2,000 kg/yr release to environment (post-treatment) 

≥ 200 kg/yr release to water (post-treatment) 

Bolding rules in the Report: Values for endpoints above that are also health or eco concerns are bolded. 

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