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Subject: email to Dr. Kotchmar from Dr Akinbami, Re: Multi-pollutant results in Akinbami et al. 

2010

From: "Akinbami, Lara (CDC/OSELS/NCHS)" <lea8@cdc.gov>

To: Dennis Kotchmar/RTP/USEPA/US@EPA

Date: 07/26/2011 04:18 PM

Subject: RE: Multi-pollutant results in Akinbami et al. 2010

For the first worksheet, SO2 is also in these models, but not NO2 which was 

highly correlated and left out of the multipollutant model. The second 

worksheet is O3, PM2.5 and PM10. Let me know if this is what you need. Keep 

in mind that the mix of counties will be different from the single pollutant 

models and between the multipollutant model including and excluding SO2. If 

you want me to rerun with identical samples, let me know. I put in into a 

spreadsheet to match the layout in the published manuscript so comparison 

should be easy.

Lara

multipollutant model.xlsx

-----Original Message-----

From: Dennis Kotchmar [mailto:Kotchmar.Dennis@epamail.epa.gov] 

Sent: Tuesday, July 19, 2011 10:45 AM

To: Akinbami, Lara (CDC/OSELS/NCHS)

Subject: RE: Multi-pollutant results in Akinbami et al. 2010

Thank you for responding. We are drafting a table for long-term respiratory 

morbidity effects that presents results on confounders, particularly PM. The 

table will attempt to present side by side the effects of ozone alone, PM 

alone, and their separate effects when they are both in the model. At the 

moment, I am considering presenting this both quantitatively and 

qualitatively. Of an available 7-8 studies that directly discuss this 2-3 

provide the OR's and CI's needed while others state that the two pollutant 

model results "were similar but less precise CI.." If possible providing the 

quantitative results will be more informative. Using the space holder 

qualitative statements sets us up to release with the OR and CI later.

Timeline to insert the quantitative results is about two weeks with some 

potential thru the first week of August.

Thank you for considering this request. I await your response.

Best Regards,

Dennis J. Kotchmar M.D.

National Center for Environmental Assessment

United States Environmental Protection Agency

919-541-4158

kotchmar.dennis@epa.gov
From: "Akinbami, Lara (CDC/OSELS/NCHS)" <lea8@cdc.gov>

To: Dennis Kotchmar/RTP/USEPA/US@EPA

Date: 07/18/2011 04:59 PM

Subject: RE: Multi-pollutant results in Akinbami et al. 2010

Hi Dennis,

This may take a while to get to. I'll try this week.

Lara

-----Original Message-----

From: Dennis Kotchmar [mailto:Kotchmar.Dennis@epamail.epa.gov]

Sent: Thursday, July 14, 2011 10:37 AM

To: Akinbami, Lara (CDC/OSELS/NCHS)

Subject: Multi-pollutant results in Akinbami et al. 2010

In your paper on asthma prevalence in the US [Akinbami, LJ; Lynch, CD; Parker, 

JD; Woodruff, TJ (2010) The association between childhood asthma prevalence 

and monitored air pollutants in metropolitan areas, United States, 2001-2004. 

Environmental Research 110:294-301] you note that multi-pollutant analysis 

was conducted yielding similar results with less precise confidence limits. If 

possible , can you provide the quantitative results showing Ozone in the 

single pollutant model with OR and CI and ozone in the two pollutant model 

with PM with OR and CI. This will help me compare this across several studies 

providing similar information

Your help will be greatly appreciated.

Thank you.

Dennis J. Kotchmar M.D.

National Center for Environmental Assessment

United States Environmental Protection Agency

919-541-4158

kotchmar.dennis@epa.gov
Odds ratios by pollutant value quartile (a) for currently having asthma or having at least one asthma attck in the previous year

Pollutant Sample size Quartile Adjusted OR (95%CI) (b) Pollutant Sample size Quartile Ad

Current asthma Asthma attack

SO2 10492 1st (lowest) Reference SO2 10492 1st (lowest) Re

2nd 0.94 (0.69, 1.27) 2nd 1.

3rd 1.34 (0.64, 2.79) 3rd 2.

4th 0.86 (0.28, 2.70) 4th 1.

O3 10492 1st (lowest) Reference O3 10492 1st (lowest) Re

2nd 1.17 (0.71, 1.92) 2nd 1.

3rd 1.36 (0.82, 2.25) 3rd 1.

4th 1.86 (1.02, 3.40) 4th 2.

PM2.5 10492 1st (lowest) Reference PM2.5 10492 1st (lowest) Re

2nd 1.01 (0.76, 1.35) 2nd 0.

3rd 0.88 (0.60, 1.28) 3rd 0.

4th 1.24 (0.70, 2.21) 4th 1.

PM10 10492 1st (lowest) Reference PM10 10492 1st (lowest) Re

2nd 0.93 (0.69, 1.26) 2nd 0.

3rd 1.16 (0.80, 1.66) 3rd 1.

4th 0.92 (0.58, 1.44) 4th 0.

a. Includes pollutant values for each county with monitored data regardless of linkage to sample children

b. Adjusted for SO2, O3, PM2.5, PM10, sex, race/ethnicity, age group, exposure to adult household smoker, single parent household

highest level of parental education, poverty status, and region of residence. NO2 not included in multipollutant model due to

high correlation with other pollutants

Multipollutant with SO2 O3 PM1 of 1"WorkSheet 1"
Odds ratios by pollutant value quartile (a) for currently having asthma or having at least one asthma attck in the previous year

Pollutant Sample size Quartile Adjusted OR (95%CI) (b) Pollutant Sample size Quartile Ad

Current asthma Asthma attackO3 13924 1st (lowest) Reference O3 13924 1st (lowest) Re

2nd 0.84 (0.62, 1.14) 2nd 0.

3rd 0.98 (0.72, 1.35) 3rd 0.

4th 1.36 (0.91, 2.02) 4th 1.

PM2.5 13924 1st (lowest) Reference PM2.5 13924 1st (lowest) Re

2nd 1.02 (0.82, 1.28) 2nd 1.

3rd 0.95 (0.70, 1.29) 3rd 0.

4th 1.26 (0.80, 1.98) 4th 1.

PM10 13924 1st (lowest) Reference PM10 13924 1st (lowest) Re

2nd 0.98 (0.78, 1.22) 2nd 1.

3rd 1.14 (0.86, 1.51) 3rd 1.

4th 0.93 (0.65, 1.35) 4th 1.

a. Includes pollutant values for each county with monitored data regardless of linkage to sample children

b. Adjusted for O3, PM2.5, PM10, sex, race/ethnicity, age group, exposure to adult household smoker, single parent household

highest level of parental education, poverty status, and region of residence.

Multipollutant with O3 PM

1 of 1

"WorkSheet 2"