**Exhibit      31.1**

**Certification      Under Section 302**

|   |                      a) designed such disclosure controls and procedures, or caused such                disclosure controls and procedures to be designed under our supervision,                to ensure that material information relating to the registrant, including                its consolidated subsidiaries, is made known to us by others within                those                entities, particularly during the period in which this report is                being                prepared;    |
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|   |                      b) designed such internal control over financial reporting, or caused                such internal control over financial reporting to be designed under                our                supervision, to provide reasonable assurance regarding the reliability                of                financial reporting and the preparation of financial statements for                external purposes in accordance with generally accepted accounting                principles;           |
|   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
|   |                      c) evaluated the effectiveness of the registrant’s disclosure                controls and procedures and presented in this report our conclusions                about                the effectiveness of the disclosure controls and procedures, as of                the end                of the period covered by this report based on such                evaluation; and                                                                                                   |
|   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
|   |                      d) disclosed in this report any change in the registrant’s internal                control over financial reporting that occurred during the registrant’s                most recent fiscal quarter (the registrant’s fourth fiscal quarter in the                case of an annual report) that has materially affected, or is reasonably                likely to materially affect, the registrant’s internal control over                financial reporting; and |

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| Date:                November 14, 2008  |   |   |   | By: |   | /s/                Noah Berkowitz, M.D., Ph.D.  |
|                                         |   |   |   |   |   | Noah                Berkowitz, M.D., Ph.D.President                and Chief Executive Officer(principal                executive officer) |

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