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                                                                   Exhibit 10.49
NABI
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                                           5800 PARK OF COMMERCE BOULEVARD, N.W.
                                                            BOCA RATON, FL 33487

                          EFFECTIVE AS OF APRIL 1, 2001

Mr. Thomas H. McLain
15975 Laurel Creek Drive
Delray Beach, FL 33446

Dear Tom:

         The Board of Directors of Nabi (the "Corporation") and the Compensation
Committee (the "Committee") of the Board have determined that it is in the best
interests of the Corporation and its shareholders for the Corporation to agree,
as provided herein, to pay you termination compensation in the event you should
leave the employ of the Corporation under the circumstances described below.

         The Board and the Committee recognize that the continuing possibility
of a sale or change of control of the Corporation is unsettling to you and other
key employees of the Corporation. Therefore, these arrangements are being made
to help assure a continuing dedication by you to your duties to the Corporation
by diminishing the inevitable distraction to you from the personal uncertainties
and risks created by a pending sale or change of control of the Corporation. In
particular, the Board and the Committee believe it important, should the
Corporation receive proposals from third parties with respect to its future, to
enable you, without being influenced by the uncertainties of your own situation,
to assess and advise the Board whether such proposals would be in the best
interests of the Corporation and its shareholders and to take such other action
regarding such proposals as the Board might determine to be appropriate,
including being available to assist in any transition should there be a sale or
change of control of the Corporation. The Board and the Committee also wish to
demonstrate to executives of the Corporation that the Corporation is concerned
with the welfare of its executives and intends to see that loyal executives are
treated fairly.

         1. In view of the foregoing and in further consideration of your
continued employment with the Corporation, the Corporation will pay you as
termination compensation a lump sum amount, determined as provided below, in the
event that (a) within six months after a Change of Control of the Corporation
you terminate your employment with the Corporation for Good Reason, (b) within
twelve months after a Change of Control of the Corporation your employment with
the Corporation is terminated by the Corporation for any reason, or (c) within
the period beginning on the sixth monthly anniversary of a Change of Control of
the Corporation and ending on the twelfth monthly anniversary thereof, you
terminate your employment with the Corporation for any reason (including,
without limitation, death or disability). The lump sum compensation so payable
(hereinafter referred to as the "Lump Sum Amount") shall be an amount equal to
two times the sum of (a) the higher of (i) your current annual base salary or
(ii) your base salary immediately prior to the Change of Control plus (b)



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your average Bonuses for the three most recently-ended fiscal years prior to the
Change of Control. The Lump Sum Amount shall be paid to you within five days
after the date of termination of your employment (hereinafter referred to as the
"Termination Date").

         2. In addition, in the event your employment with the Corporation
terminates under circumstances entitling you to receive the Lump Sum Amount:

                  (a) Any compensation and other amounts previously deferred by
         you, together with accrued interest thereon, if any, to which you are
         entitled, and any accrued vacation pay and accrued paid leave bank
         amounts not yet paid by the Corporation, shall be paid to you within
         five days of such termination.

                  (b) All other amounts accrued or earned by you through the
         date of such termination and amounts otherwise owing under the
         Corporation's plans and policies shall be paid to you within five days
         of such termination.

                  (c) The Corporation shall maintain in full force and effect,
         for the continued benefit of you and/or your family for twenty-four
         months after the Termination Date, all employee welfare benefit plans
         and any other employee benefit programs or arrangements (including,
         without limitation, medical and dental insurance plans, disability and
         life insurance plans and car allowance programs) in which you were
         entitled to participate immediately prior to the Change of Control,
         provided that your continued participation is possible under the
         general terms and provisions of such plans and programs. In the event
         that your participation in any such plan or program is barred, the
         Corporation shall arrange to provide you with benefits substantially
         similar to those which you are entitled to receive under such plans and
         programs.

                  (d) All outstanding stock options which you hold shall vest
         immediately upon a Change of Control and shall be exercisable for (i)
         the remainder of the option term(s) or (ii) a period of five years from
         the Termination Date, whichever is shorter.

                  (e) The Corporation shall pay up to $25,000 for outplacement
         services provided to you by an organization selected by you.

                  (f) You shall not be required to mitigate the amount of any
         payment provided for in this Agreement by seeking other employment or
         otherwise, nor shall the amount of any payment provided for in this
         Agreement be reduced by any compensation earned by you as the result of
         employment by another employer after the Termination Date, or
         otherwise. The Corporation's obligation to make the payments provided
         for in this Agreement and otherwise to perform its obligations
         hereunder shall not be affected by any set-off, counterclaim,
         recoupment, defense or other claim, right or action which it may have
         against you or others.

                  3. Any termination by you for Good Reason shall be
communicated by a written notice given within 120 days of your having actual
notice of the events giving rise to a right to terminate for Good Reason and
which (i) sets forth in reasonable detail the facts and




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circumstances claimed to provide a basis for termination for Good Reason and
(ii), if the Termination Date is other than the date of receipt of such notice,
specifies the Termination Date (which date shall not be more than 15 days after
the giving of such notice). Your failure to set forth in the notice of
termination any fact or circumstance which contributes to a showing of Good
Reason shall not waive any right of yours hereunder or preclude you from
asserting such fact or circumstance in enforcing your rights hereunder.

         4.  For purposes of this Agreement:

                  (a) "Bonus" means bonus or incentive compensation paid or
         payable by the Corporation to you pursuant to plans which the
         Corporation now maintains or has maintained including, but not limited
         to, signing bonuses. If your Bonus for a fiscal year has been pro rated
         because you were not employed by the Corporation for the entire fiscal
         year, the pro ration shall be ignored and you shall be deemed to have
         received the entire Bonus for the year.

                  (b) "Exchange Act" means the Securities Exchange Act of 1934,
         as amended.

                  (c) A "Change of Control" shall be deemed to have taken place
         if (i) any "person" (as such term is used in Sections 13(d) and
         14(d)(2) of the Exchange Act) is or becomes the beneficial owner
         (within the meaning of Rule 13d-3 promulgated under the Exchange Act),
         directly or indirectly, of securities of the Corporation representing
         25% or more of the combined voting power of the Corporation's then
         outstanding securities; (ii) the shareholders of the Corporation shall
         have approved (A) a reorganization, merger or consolidation, in each
         case, with respect to which persons who were shareholders of the
         Corporation immediately prior to such reorganization, merger or
         consolidation do not, immediately thereafter, own more than 50% of the
         combined voting power entitled to vote generally in the election of
         directors of the reorganized, merged or consolidated company's then
         outstanding voting securities or (B) a liquidation or dissolution of
         the Corporation; or (iii) as the result of a tender offer, exchange
         offer, merger, consolidation, sale of assets or contested solicitation
         of proxies or any combination of the foregoing transactions (a
         "Transaction"), the persons who were directors of the Corporation
         immediately before the Transaction shall cease to constitute a majority
         of the Board of Directors of the Corporation or of any parent of or
         successor to the Corporation immediately after the Transaction occurs.

                  (d)      "Good Reason" means:

                           (i) The assignment to you of any duties inconsistent
                  in any material adverse respect with your position (including
                  status, offices, titles and reporting requirements),
                  authority, duties or responsibilities as in effect on the date
                  of the Change of Control, or any other action by the
                  Corporation which results in a diminution in such position,
                  authority, duties or responsibilities, excluding for this
                  purpose an isolated, insubstantial and inadvertent action not
                  taken in bad faith and which is remedied by the Corporation
                  promptly after receipt of notice from you;




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                           (ii) Any reduction of your base salary or the failure
                  by the Corporation to provide you with an incentive
                  compensation program, welfare benefits, retirement benefits
                  and other benefits which in the aggregate are no less
                  favorable than the benefits to which you were entitled prior
                  to the Change of Control;

                           (iii) The Corporation's requiring you to be based at
                  any office or location more than 15 miles from that location
                  at which you are employed on the date of the Change of
                  Control, except for travel reasonably required in the
                  performance of your responsibilities;

                           (iv) Any action taken or suffered by the Corporation
                  as of or following the Change of Control (such as, without
                  limitation, transfer or encumbrance of assets or incurring of
                  indebtedness) which materially impairs the ability of the
                  Corporation to make any payments due or which may become due
                  to you under this Agreement; or

                           (v) any failure by the Corporation to obtain the
                  assumption and agreement to perform this Agreement by a
                  successor as contemplated by Section 10.

         5.(a) Anything in this Agreement to the contrary notwithstanding, in
the event it shall be determined that any payment or distribution by the
Corporation to you or for your benefit, whether paid or payable or distributed
or distributable pursuant to the terms of this Agreement or otherwise (a
"Payment"), would be subject to the excise tax imposed by Section 4999 of the
Internal Revenue Code of 1986, as amended (the "Code") or any interest or
penalties with respect to such excise tax (such excise tax, together with any
such interest and penalties, are hereinafter collectively referred to as the
"Excise Tax"), then you shall be entitled to receive an additional payment (a
"Gross-Up Payment") in an amount such that after payment by you of all taxes
(including any interest or penalties imposed with respect to such taxes),
including any Excise Tax, imposed upon the Gross-Up Payment, you retain an
amount of the Gross-Up Payment equal to the Excise Tax imposed upon the
Payments.

         (b) Subject to the provisions of Section 5(c), all determinations
required to be made under this Section 5, including whether a Gross-Up Payment
is required and the amount of such Gross-Up Payment, shall be made by Ernst &
Young (the "Accounting Firm") which shall provide detailed supporting
calculations both to the Corporation and you within 15 business days of the date
your employment with the Corporation terminates, or such earlier time as is
requested by the Corporation. If the Accounting Firm determines that no Excise
Tax is payable to you, it shall furnish you with an opinion that you have
substantial authority not to report any Excise Tax on your federal income tax
return. Any determination by the Accounting Firm shall be binding upon the
Corporation and you. As a result of the uncertainty in the application of
Section 4999 of the Code at the time of the initial determination by the
Accounting Firm hereunder, it is possible that Gross-Up Payments which will not
have been made by the Corporation should have been made ("Underpayment"),
consistent with the calculations required to be made hereunder. In the event
that the Corporation exhausts its remedies




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pursuant to Section 5(c) and you thereafter are required to make a payment of
any Excise Tax, the Accounting Firm shall determine the amount of the
Underpayment that has occurred and any such Underpayment shall be promptly paid
by the Corporation to you or for your benefit.

         (c) You shall notify the Corporation in writing of any claim by the
Internal Revenue Service that, if successful, would require the payment by the
Corporation of the Gross-Up Payment. Such notification shall be given as soon as
practicable but no later than ten business days after you know of such claim and
shall apprise the Corporation of the nature of such claim and the date on which
such claim is requested to be paid. You shall not pay such claim prior to the
expiration of the thirty-day period following the date on which you give such
notice to the Corporation (or such shorter period ending on the date that any
payment of taxes with respect to such claim is due). If the Corporation notifies
you in writing prior to the expiration of such period that it desires to contest
such claim, you shall:

                  (i) give the Corporation any information reasonably requested
         by the Corporation relating to such a claim,

                  (ii) take such action in connection with contesting such claim
         as the Corporation shall reasonably request in writing from time to
         time, including, without limitation, accepting legal representation
         with regard to such claim by an attorney reasonably selected by the
         Corporation,

                  (iii) cooperate with the Corporation in good faith in order
         effectively to contest such claim, and

                  (iv) permit the Corporation to participate in any proceedings
         relating to such claim;

provided, however, that the Corporation shall bear and pay directly all costs
and expenses (including additional interest and penalties) incurred in
connection with such contest and shall indemnify and hold you harmless, on an
after-tax basis, for an Excise Tax or income tax, including interest and
penalties with respect thereto, imposed as a result of such representation and
payment of costs and expenses. Without limitation of the foregoing provisions of
this Section 5(c), the Corporation shall control all proceedings taken in
connection with such contest and, at its sole option, may pursue or forgo any
and all administrative appeals, proceedings, hearings and conferences with the
taxing authority in respect of such claim and may, at its sole option, either
direct you to pay the tax claimed and sue for a refund or contest the claim in
any permissible manner, and you agree to prosecute such contest to a
determination before any administrative tribunal, in a court of initial
jurisdiction and in one or more appellate courts, as the Corporation shall
determine; provided, however, that if the Corporation directs you to pay such
claim and sue for a refund, the Corporation shall advance the amount of such
payment to you, on an interest-free basis and shall indemnify and hold you
harmless, on an after-tax basis, from any Excise Tax or income tax, including
interest or penalties with respect thereto, imposed with respect to such advance
or with respect to any imputed income with respect to such advance; and further
provided that any extension of the statute of limitations related to payment of
taxes for your taxable year with respect to which such contested amount is
claimed to be due



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is limited solely to such contested amount. Furthermore, the Corporation's
control of the contest shall be limited to issues with respect to which a
Gross-Up Payment would be payable hereunder and you shall be entitled to settle
or contest, as the case may be, any other issue raised by the Internal Revenue
Service or any other taxing authority.

         (d) If, after the receipt by you of an amount advanced by the
Corporation pursuant to Section 5(c), you become entitled to receive any refund
with respect to such claim, you shall (subject to the Corporation's complying
with the requirements of Section 5(c)) promptly pay to the Corporation the
amount of such refund (together with any interest paid or credited thereon after
taxes applicable thereto). If, after the receipt by you of an amount advanced by
the Corporation pursuant to Section 5(c), a determination is made that you shall
not be entitled to any refund with respect to such claim and the Corporation
does not notify you in writing of its intent to contest such denial of refund
prior to the expiration of thirty days after such determination, then such
advance shall be forgiven and shall not be required to be repaid and the amount
of such advance shall offset, to the extent thereof, the amount of Gross-Up
Payment required to be paid.

         6. Anything in this Agreement to the contrary notwithstanding, if your
employment with the Corporation is terminated prior to the date on which a
Change of Control occurs, and it is reasonably demonstrated by you that such
termination (a) was at the request of a third party who has taken steps
reasonably calculated to effect a Change of Control or (b) otherwise arose in
connection with or in anticipation of a Change of Control, then for all purposes
of this Agreement, a Change of Control shall be deemed to have occurred the date
immediately prior to the date of such termination.

         7. This Agreement shall be binding upon and inure to the benefit of
you, your estate and the Corporation and any successor or assign of the
Corporation, but neither this Agreement nor any rights arising hereunder may be
assigned or pledged by you. If you should die while any amount would still be
payable to you hereunder if you had continued to live, all such amounts, unless
otherwise provided herein, shall be paid in accordance with the terms of this
Agreement to your devisee, legatee, or other designee or, if there by no such
designee, to your estate.

         8. For purposes of this Agreement, notices and all other communications
provided for in the Agreement shall be in writing and shall be deemed to have
been duly given when delivered or mailed by United States registered mail,
return receipt requested, postage prepaid, addressed, in your case, to the
address set forth on the first page of this Agreement and, in the Corporation's
case, to the address of its principal office (all notices to the Corporation to
be directed to the attention of the President of the Corporation with a copy to
the Secretary of the Corporation) or to such other address as either party may
have furnished to the other in writing in accordance herewith, except that
notices of change of address shall be effective only upon receipt.

         9. No provisions of this Agreement may be modified, waived or
discharged unless such waiver, modification or discharge is agreed to in writing
signed by you and such officer as may be specifically designated by the Board of
Directors of the Corporation. No waiver by either party hereto at any time of
any breach by the other party hereto of, or compliance with,



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any condition or provision of this Agreement to be performed by such other party
shall be deemed a waiver of similar or dissimilar provisions or conditions at
the time or at any prior or subsequent time. No agreements or representations,
oral or otherwise, express or implied, with respect to the subject matter hereof
have been made by either party which are not set forth expressly in this
Agreement. The validity, interpretation, construction and performance of this
Agreement shall be governed by the laws of the State of Florida without regard
to principles of conflicts of laws.

         10. The Corporation will require any successor (whether direct or
indirect, by purchase, merger, consolidation or otherwise) to all or
substantially all of the business and/or assets of the Corporation to expressly
assume and agree to perform this Agreement in the same manner and to the same
extent that the Corporation would be required to perform it if no such
succession had taken place. As used in this Agreement, "Corporation" shall mean
the Corporation as hereinbefore defined and any successor to its business and/or
assets as aforesaid which assumes and agrees to perform this Agreement by
operation of law, or otherwise.

         11. Nothing in this Agreement shall prevent or limit your continuing or
future participation in any benefit, bonus, incentive or other plan or program
provided by the Corporation and for which you may qualify, nor shall anything
herein limit or otherwise prejudice such rights as you may have under any other
agreements with the Corporation. Amounts which are vested benefits or which you
are otherwise entitled to receive under any plan or program of the Corporation
at or subsequent to any Change of Control shall be payable in accordance with
such plan or program. To the extent the terms of any other agreements you may
have with the Corporation are inconsistent with this Agreement, the terms of
this Agreement shall control.

         12. If you assert any claim in any contest (whether initiated by you or
by the Corporation) as to the validity, enforceability or interpretation of any
provision of this Agreement, the Corporation shall pay your legal expenses (or
cause such expenses to be paid), including, without limitation, your reasonable
attorneys' fees, on a quarterly basis, upon presentation of proof of such
expenses in a form reasonably acceptable to the Corporation, provided that you
shall reimburse the Corporation for such amounts, plus simple interest thereon
at the 90-day United States Treasury Bill rate as in effect from time to time,
compounded annually, if a court of competent jurisdiction shall find that you
did not have a good faith and reasonable basis to believe that you would prevail
as to at least one material issue presented to such court.

         13. The invalidity or unenforceability of any provisions of this
Agreement shall not affect the validity or enforceability of any other provision
of this Agreement, which shall remain in full force and effect.

         14. This Agreement may be executed in one or more counterparts, each of
which shall be deemed to be an original but all of which together will
constitute one and the same instrument.




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         If you are in agreement with the foregoing, please so indicate by
signing and returning to the Corporation the enclosed copy of this letter,
whereupon this letter shall constitute a binding agreement under seal between
you and the Corporation.

                                       Very truly yours,


                                       NABI



                                       By /s/ DAVID J. GURY
                                          --------------------------------------
                                          Name: David J. Gury
                                          Title: Chairman, President and
                                                 Chief Executive Officer

Agreed:

/s/ THOMAS H. McLAIN
-----------------------------
Name: Thomas H. McLain







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