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Subject: email to Dr. Kotchmar from Dr Akinbami, Re: Multi-pollutant results in Akinbami et al.

2010

From: "Akinbami, Lara (CDC/OSELS/NCHS)" <lea8@cdc.gov>

To: Dennis Kotchmar/RTP/USEPA/US@EPA

Date: 07/26/2011 04:18 PM

Subject: RE: Multi-pollutant results in Akinbami et al. 2010



# For the first worksheet, SO2 is also in these model s, but not NO2 which was

highly correlated and left out of the multipollutan t model. The second

worksheet is O3, PM2.5 and PM10. Let me know if th is is what you need. Keep

in mind that the mix of counties will be different from the single pollutant

models and between the multipollutant model includi ng and excluding SO2. If

you want me to rerun with identical samples, let me know. I put in into a

spreadsheet to match the layout in the published ma nuscript so comparison

should be easy.

Lara

multipollutant model.xlsx



# -----Original Message-----

From: Dennis Kotchmar [mailto:Kotchmar.Dennis@epama il.epa.gov]

Sent: Tuesday, July 19, 2011 10:45 AM

To: Akinbami, Lara (CDC/OSELS/NCHS)

Subject: RE: Multi-pollutant results in Akinbami et al. 2010

Thank you for responding. We are drafting a table f or long-term respiratory

morbidity effects that presents results on confound ers, particularly PM. The

table will attempt to present side by side the effe cts of ozone alone, PM

alone, and their separate effects when they are bot h in the model. At the

moment, I am considering presenting this both quant itatively and

qualitatively. Of an available 7-8 studies that dir ectly discuss this 2-3

provide the OR's and CI's needed while others state that the two pollutant

model results "were similar but less precise CI.." If possible providing the

quantitative results will be more informative. Usin g the space holder

qualitative statements sets us up to release with the OR and CI later.

Timeline to insert the quantitative results is abou t two weeks with some

potential thru the first week of August.

Thank you for considering this request. I await you r response.

Best Regards,

Dennis J. Kotchmar M.D.

National Center for Environmental Assessment

United States Environmental Protection Agency

919-541-4158

kotchmar.dennis@epa.gov

# From: "Akinbami, Lara (CDC/OSELS/NCHS)" <lea8@cdc.g ov>

To: Dennis Kotchmar/RTP/USEPA/US@EPA

Date: 07/18/2011 04:59 PM

Subject: RE: Multi-pollutant results in Akinbami et al. 2010

Hi Dennis,

This may take a while to get to. I'll try this wee k.

Lara

-----Original Message-----

From: Dennis Kotchmar [mailto:Kotchmar.Dennis@epama il.epa.gov]

Sent: Thursday, July 14, 2011 10:37 AM

To: Akinbami, Lara (CDC/OSELS/NCHS)

Subject: Multi-pollutant results in Akinbami et al. 2010

In your paper on asthma prevalence in the US [Akinb ami, LJ; Lynch, CD; Parker,

JD; Woodruff, TJ (2010) The association between chi ldhood asthma prevalence

and monitored air pollutants in metropolitan areas, United States, 2001-2004.

Environmental Research 110:294-301] you note that multi-pollutant analysis

was conducted yielding similar results with less pr ecise confidence limits. If

possible , can you provide the quantitative results showing Ozone in the

single pollutant model with OR and CI and ozone in the two pollutant model

with PM with OR and CI. This will help me compare t his across several studies

providing similar information

Your help will be greatly appreciated.

Thank you.

Dennis J. Kotchmar M.D.

National Center for Environmental Assessment

United States Environmental Protection Agency

919-541-4158

kotchmar.dennis@epa.govOddsratiosbypollutantvaluequartile(a)forcurrentlyhavingasthmaorhavingatleastoneasthmaattckinthepreviousyearPollutant Samplesize Quartile AdjustedOR(95%CI)(b) Pollutant Samplesize Quartile AdjustedOR(95%CI)(b)Currentasthma AsthmaattackSO2 10492 1st(lowest) Reference SO2 10492 1st(lowest) Reference2nd 0.94(0.69,1.27) 2nd 1.05(0.71,1.55)3rd 1.34(0.64,2.79) 3rd 2.15(0.84,5.53)4th 0.86(0.28,2.70) 4th 1.06(0.15,7.57)O3 10492 1st(lowest) Reference O3 10492 1st(lowest) Reference2nd 1.17(0.71,1.92) 2nd 1.26(0.66,2.42)3rd 1.36(0.82,2.25) 3rd 1.50(0.77,2.92)4th 1.86(1.02,3.40) 4th 2.16(0.95,4.90)PM2.5 10492 1st(lowest) Reference PM2.5 10492 1st(lowest) Reference2nd 1.01(0.76,1.35) 2nd 0.99(0.70,1.41)3rd 0.88(0.60,1.28) 3rd 0.75(0.48,1.16)4th 1.24(0.70,2.21) 4th 1.01(0.48,2.15)PM10 10492 1st(lowest) Reference PM10 10492 1st(lowest) Reference2nd 0.93(0.69,1.26) 2nd 0.81(0.58,1.12)3rd 1.16(0.80,1.66) 3rd 1.06(0.72,1.57)4th 0.92(0.58,1.44) 4th 0.94(0.57,1.54)a.Includespollutantvaluesforeachcountywithmonitoreddataregardlessoflinkagetosamplechildrenb.AdjustedforSO2,O3,PM2.5,PM10,sex,race/ethnicity,agegroup,exposuretoadulthouseholdsmoker,singleparenthouseholdhighestlevelofparentaleducation,povertystatus,andregionofresidence.NO2notincludedinmultipollutantmodelduetohighcorrelationwithotherpollutantsMultipollutantwithSO2O3PM1of1"WorkSheet1"Oddsratiosbypollutantvaluequartile(a)forcurrentlyhavingasthmaorhavingatleastoneasthmaattckinthepreviousyearPollutant Samplesize Quartile AdjustedOR(95%CI)(b) Pollutant Samplesize Quartile AdjustedOR(95%CI)(b)Currentasthma AsthmaattackO3 13924 1st(lowest) Reference O3 13924 1st(lowest) Reference2nd 0.84(0.62,1.14) 2nd 0.76(0.51,1.15)3rd 0.98(0.72,1.35) 3rd 0.92(0.60,1.43)4th 1.36(0.91,2.02) 4th 1.26(0.75,2.10)PM2.5 13924 1st(lowest) Reference PM2.5 13924 1st(lowest) Reference2nd 1.02(0.82,1.28) 2nd 1.07(0.81,1.40)3rd 0.95(0.70,1.29) 3rd 0.88(0.62,1.24)4th 1.26(0.80,1.98) 4th 1.04(0.58,1.86)PM10 13924 1st(lowest) Reference PM10 13924 1st(lowest) Reference2nd 0.98(0.78,1.22) 2nd 1.00(0.76,1.31)3rd 1.14(0.86,1.51) 3rd 1.18(0.85,1.65)4th 0.93(0.65,1.35) 4th 1.16(0.75,1.78)a.Includespollutantvaluesforeachcountywithmonitoreddataregardlessoflinkagetosamplechildrenb.AdjustedforO3,PM2.5,PM10,sex,race/ethnicity,agegroup,exposuretoadulthouseholdsmoker,singleparenthouseholdhighestlevelofparentaleducation,povertystatus,andregionofresidence.MultipollutantwithO3PM1of1"WorkSheet2"