# Patent

## Title
N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase

## Abstract

Novel substituted benzamide based inhibitors, their use in therapy, pharmaceutical compositions comprising the compounds, the use of said compounds in the manufacture of medicaments, and therapeutic methods comprising the administration of said compounds are described. The present compounds modulate the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, such as the metabolic syndrome.

## Background
The present invention relates to novel substituted benzamide based inhibitors, to their use in therapy, to pharmaceutical compositions comprising the compounds, to the use of said compounds in the manufacture of medicaments, and to therapeutic methods comprising the administration of said compounds. The present compounds modulate the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and are accordingly useful in the treatment of diseases in which such a modulation is beneficial, such as the metabolic syndrome.
BACKGROUND OF THE INVENTION
The metabolic syndrome is a major global health problem. In the US, the prevalence in the adult population is currently estimated to be approximately 25%, and it continues to increase both in the US and worldwide. The metabolic syndrome is characterised by a combination of insulin resistance, dyslipidemia, obesity and hypertension leading to increased morbidity and mortality of cardiovascular diseases. People with the metabolic syndrome are at increased risk of developing frank type 2 diabetes, the prevalence of which is equally escalating.
In type 2 diabetes, obesity and dyslipidemia are also highly prevalent and around 70% of people with type 2 diabetes additionally have hypertension once again leading to increased mortality of cardiovascular diseases.
In the clinical setting, it has long been known that glucocorticoids are able to induce all of the cardinal features of the metabolic syndrome and type 2 diabetes.
11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) catalyses the local generation of active glucocorticoid in several tissues and organs including predominantly the liver and adipose tissue, but also e.g. skeletal muscle, bone, pancreas, endothelium, ocular tissue and certain parts of the central nervous system. Thus, 11βHSD1 serves as a local regulator of glucocorticoid actions in the tissues and organs where it is expressed (Tannin et al., J. Biol. Chem., 266, 16653 (1991); Bujalska et al., Endocrinology, 140, 3188 (1999); Whorwood et al., J Clin Endocrinol Metab., 86, 2296 (2001); Cooper et al., Bone, 27, 375 (2000); Davani et al., J. Biol. Chem., 275, 34841 (2000); Brem et al., Hypertension, 31, 459 (1998); Rauz et al., Invest. Ophthalmol. Vis. Sci., 42, 2037 (2001); Moisan et al., Endocrinology, 127, 1450 (1990)).
The role of 11βHSD1 in the metabolic syndrome and type 2 diabetes is supported by several lines of evidence. In humans, treatment with the non-specific 11βHSD1 inhibitor carbenoxolone improves insulin sensitivity in lean healthy volunteers and people with type 2 diabetes. Likewise, 11βHSD1 knock-out mice are resistant to insulin resistance induced by obesity and stress. Additionally, the knock-out mice present with an anti-atherogenic lipid profile of decreased VLDL triglycerides and increased HDL-cholesterol. Conversely, mice that overexpress 11βHSD1 in adipocytes develop insulin resistance, hyperlipidemia and visceral obesity, a phenotype that resembles the human metabolic syndrome (Andrews et al., J. Clin. Endocrinol. Metab., 88, 285 (2003); Walker et al., J. Clin. Endocrinol. Metab., 80, 3155 (1995); Morton et al., J. Biol. Chem., 276, 41293 (2001); Kotelevtsev et al., Proc. Natl. Acad. Sci. USA, 94, 14924 (1997); Masuzaki et al., Science, 294, 2166 (2001)).
The more mechanistic aspects of 11βHSD1 modulation and thereby modulation of intracellular levels of active glucocorticoid have been investigated in several rodent models and different cellular systems. 11βHSD1 promotes the features of the metabolic syndrome by increasing hepatic expression of the rate-limiting enzymes in gluconeogenesis, namely phosphoenolpyuvate carboxykinase and glucose-6-phosphatase, promoting the differentiation of preadipocytes into adipocytes thus facilitating obesity, directly and indirectly stimulating hepatic VLDL secretion, decreasing hepatic LDL uptake and increasing vessel contractility (Kotelevtsev et al., Proc. Natl. Acad. Sci. USA, 94, 14924 (1997); Morton et al., J. Biol. Chem. 276, 41293 (2001); Bujalska et al., Endocrinology, 140, 3188 (1999); Souness et al., Steroids, 67, 195 (2002), Brindley & Salter, Prog. Lipid Res., 30, 349 (1991)).
WO 01/90090, WO 01/90091, WO 01/90092, WO 01/90093 and WO 01/90094 discloses various thiazol-sulfonamides as inhibitors of the human 11β-hydroxysteroid dehydrogenase type 1 enzyme, and further states that said compounds may be useful in treating diabetes, obesity, glaucoma, osteoporosis, cognitive disorders, immune disorders and depression. WO 2004/089470 discloses various substituted amides and the use thereof for stimulating 11β-hydroxysteroid dehydrogenase type 1. WO 2004/089415 and WO 2004/089416 discloses various combination therapies using an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and respectively a glucocorticoid receptor agonist or an antihypertensive agent.
We have now found substituted benzamide based inhibitors that modulate the activity of 11βHSD1 leading to altered intracellular concentrations of active glucocorticoid. More specifically, the present compounds inhibit the activity of 11βHSD1 leading to decreased intracellular concentrations of active glucocorticoid. Thus, the present compounds can be used to treat disorders where a decreased level of active intracellular glucocorticoid is desirable, such as e.g. the metabolic syndrome, type 2 diabetes, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), dyslipidemia, obesity, hypertension, diabetic late complications, cardiovascular diseases, arteriosclerosis, atherosclerosis, myopathy, muscle wasting, osteoporosis, neurodegenerative and psychiatric disorders, and adverse effects of treatment or therapy with glucocorticoid receptor agonists.
One object of the present invention is to provide compounds, pharmaceutical compositions and use of compounds that modulate the activity of 11βHSD1.
DEFINITIONS
The term “monovalent radical” shall mean a chemical group attached via a single bond. The term “halogen” or “halo” means fluorine, chlorine, bromine or iodine.
The term “hydroxy” shall mean the radical —OH.
The term “carboxy” shall mean the radical —(C═O)OH.
The term “C1-C6alkyl” as used herein represents a saturated, branched or straight hydrocarbon group having from 1 to 6 carbon atoms, e.g. C1-C2alkyl, C1-C3alkyl, C1-C4alkyl, C1-C6alkyl, C2-C6alkyl, C3-C6alkyl, and the like. Representative examples are methyl, ethyl, propyl (e.g. prop-1-yl, prop-2-yl (or iso-propyl)), butyl (e.g. 2-methylprop-2-yl (or tert-butyl), but-1-yl, but-2-yl), pentyl (e.g. pent-1-yl, pent-2-yl, pent-3-yl), 2-methylbut-1-yl, 3-methylbut-1-yl, hexyl (e.g. hex-1-yl), and the like. The term “C1-C4alkyl” as used herein represents a saturated, branched or straight hydrocarbon group having from 1 to 4 carbon atoms, e.g. C1-C2alkyl, C1-C3alkyl, C1-C4alkyl, and the like. Representative examples are methyl, ethyl, propyl (e.g. prop-1-yl, prop-2-yl (or iso-propyl)), butyl (e.g. 2-methylprop-2-yl (or tert-butyl), but-1-yl, but-2-yl), and the like.
The term “bridge” as used herein represents a connection in a saturated or partly saturated ring between two atoms of such ring that are not neighbors through a chain of 1 to 3 atoms selected from carbon, nitrogen, oxygen and sulfur. Representative examples of such connecting chains are —CH2—, —CH2CH2—, —CH2NHCH2—, —CH2CH2CH2—, —CH2OCH2—, and the like. In one embodiment according to the invention, the connecting chain is selected from the group consisting of —CH2—, —CH2CH2—, or —CH2OCH2—.
The term “spiro atom” as used herein represents a carbon atom in a saturated or partly saturated ring that connects both ends of a chain of 3 to 7 atoms selected from carbon, nitrogen, oxygen and sulfur. Representative examples are —(CH2)5—, —(CH2)3—, —(CH2)4—, —CH2NHCH2CH2—, —CH2CH2NHCH2CH2—, —CH2NHCH2CH2CH2—, —CH2CH2OCH2—, —OCH2CH2O—, and the like.
The term “C3-C10cycloalkyl” as used herein represents a saturated monocyclic carbocyclic ring having from 3 to 10 carbon atoms, e.g. C3-6-alkyl, C3-10-alkyl, and the like.
Representative examples are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and the like. C3-C10cycloalkyl is also intended to represent a saturated bicyclic carbocyclic ring having from 4 to 10 carbon atoms. Representative examples are decahydro-naphthalenyl, bicyclo[3.3.0]octanyl, and the like. C3-C10cycloalkyl is also intended to represent a saturated carbocyclic ring having from 3 to 10 carbon atoms and containing one or two carbon bridges. Representative examples are adamantyl, norbornanyl, nortricyclyl, bicyclo[3.2.1]octanyl, bicyclo[2.2.2]octanyl, tricyclo[5.2.1.0/2,6]decanyl, bicyclo[2.2.1]-heptyl, and the like. C3-C10cycloalkyl is also intended to represent a saturated carbocyclic ring having from 3 to 10 carbon atoms and containing one or more spiro atoms. Representative examples are spiro[2.5]octanyl, spiro[4.5]decanyl, and the like.
The term “aryl” as used herein is intended to include monocyclic, bicyclic or polycyclic carbocyclic aromatic rings. Representative examples are phenyl, naphthyl (e.g. naphth-1-yl, naphth-2-yl), anthryl (e.g. anthr-1-yl, anthr-9-yl), phenanthryl (e.g. phenanthr-1-yl, phenanthr-9-yl), and the like. Aryl is also intended to include monocyclic, bicyclic or polycyclic carbocyclic aromatic rings substituted with carbocyclic aromatic rings. Representative examples are biphenyl (e.g. biphenyl-2-yl, biphenyl-3-yl, biphenyl-4-yl), phenylnaphthyl (e.g. 1-phenylnaphth-2-yl, 2-phenylnaphth-1-yl), and the like. Aryl is also intended to include partially saturated bicyclic or polycyclic carbocyclic rings with at least one unsaturated moiety (e.g. a benzo moiety). Representative examples are, indanyl (e.g. indan-1-yl, indan-5-yl), indenyl (e.g. inden-1-yl, inden-5-yl), 1,2,3,4-tetrahydronaphthyl (e.g. 1,2,3,4-tetrahydronaphth-1-yl, 1,2,3,4-tetrahydronaphth-2-yl, 1,2,3,4-tetrahydronaphth-6-yl), 1,2-dihydronaphthyl (e.g. 1,2-dihydronaphth-1-yl, 1,2-dihydronaphth-4-yl, 1,2-dihydronaphth-6-yl), fluorenyl (e.g. fluoren-1-yl, fluoren-4-yl, fluoren-9-yl), and the like. Aryl is also intended to include partially saturated bicyclic or polycyclic carbocyclic aromatic rings containing one or two bridges. Representative examples are, benzonorbornyl (e.g. benzonorborn-3-yl, benzonorborn-6-yl), 1,4-ethano-1,2,3,4-tetrahydronapthyl (e.g. 1,4-ethano-1,2,3,4-tetrahydronapth-2-yl, 1,4-ethano-1,2,3,4-tetrahydronapth-10-yl), and the like. Aryl is also intended to include partially saturated bicyclic or polycyclic carbocyclic aromatic rings containing one or more spiro atoms. Representative examples are spiro[cyclopentane-1,1′-indane]-4-yl, spiro[cyclopentane-1,1′-indene]-4-yl, spiro[piperidine-4,1′-indane]-1-yl, spiro[piperidine-3,2′-indane]-1-yl, spiro[piperidine-4,2′-indane]-1-yl, spiro[piperidine-4,1′-indane]-3′-yl, spiro[pyrrolidine-3,2′-indane]-1-yl, spiro[pyrrolidine-3,1′-(3′,4′-dihydronaphthalene)]-1-yl, spiro[piperidine-3,1′-(3′,4′-dihydronaphthalene)]-1-yl, spiro[piperidine-4,1′-(3′,4′-dihydronaphthalene)]-1-yl, spiro[imidazolidine-4,2′-indane]-1-yl, spiro[piperidine-4,1′-indene]-1-yl, and the like.
The term “C3-C10heterocyclyl” as used herein represents a saturated 3 to 10 membered monocyclic ring, containing one or more heteroatoms selected from nitrogen, oxygen, sulfur, S(═O) and S(═O)2. Representative examples are aziridinyl (e.g. aziridin-1-yl), azetidinyl (e.g. azetidin-1-yl, azetidin-3-yl), oxetanyl, pyrrolidinyl (e.g. pyrrolidin-1-yl, pyrrolidin-2-yl, pyrrolidin-3-yl), imidazolidinyl (e.g. imidazolidin-1-yl, imidazolidin-2-yl, imidazolidin-4-yl), oxazolidinyl (e.g. oxazolidin-2-yl, oxazolidin-3-yl, oxazolidin-4-yl), thiazolidinyl (e.g. thiazolidin-2-yl, thiazolidin-3-yl, thiazolidin-4-yl), isothiazolidinyl, piperidinyl (e.g. piperidin-1-yl, piperidin-2-yl, piperidin-3-yl, piperidin-4-yl), homopiperidinyl (e.g. homopiperidin-1-yl, homopiperidin-2-yl, homopiperidin-3-yl, homopiperidin-4-yl), piperazinyl (e.g. piperazin-1-yl, piperazin-2-yl), morpholinyl (e.g. morpholin-2-yl, morpholin-3-yl, morpholin-4-yl), thiomorpholinyl (e.g. thiomorpholin-2-yl, thiomorpholin-3-yl, thiomorpholin-4-yl), 1-oxothiomorpholinyl, 1,1-dioxo-thiomorpholinyl, tetrahydrofuranyl (e.g. tetrahydrofuran-2-yl, tetrahydrofuran-3-yl), tetrahydrothienyl, tetrahydro-1,1-dioxothienyl, tetrahydropyranyl (e.g. 2-tetrahydropyranyl), tetrahydrothiopyranyl (e.g. 2-tetrahydrothiopyranyl), 1,4-dioxanyl, 1,3-dioxanyl, and the like. C3-C10heterocyclyl is also intended to represent a saturated 6 to 10 membered bicyclic ring containing one or more heteroatoms selected from nitrogen, oxygen, sulfur, S(═O) and S(═O)2. Representative examples are octahydroindolyl (e.g. octahydroindol-1-yl, octahydroindol-2-yl, octahydroindol-3-yl, octahydroindol-5-yl), decahydroquinolinyl (e.g. decahydroquinolin-1-yl, decahydroquinolin-2-yl, decahydroquinolin-3-yl, decahydroquinolin-4-yl, decahydroquinolin-6-yl), decahydroquinoxalinyl (e.g. decahydroquinoxalin-1-yl, decahydroquinoxalin-2-yl, decahydroquinoxalin-6-yl) and the like. C3-C10heterocyclyl is also intended to represent a saturated 6 to 10 membered ring containing one or more heteroatoms selected from nitrogen, oxygen, sulfur, S(═O) and S(═O)2 and having one or two bridges. Representative examples are 3-azabicyclo-[3.2.2]nonyl, 2-azabicyclo[2.2.1]heptyl, 3-azabicyclo[3.1.0]hexyl, 2,5-diazabicyclo-[2.2.1]heptyl, atropinyl, tropinyl, quinuclidinyl, 1,4-diazabicyclo[2.2.2]octanyl, and the like. C3-C10heterocyclyl is also intended to represent a 6 to 10 membered saturated ring containing one or more heteroatoms selected from nitrogen, oxygen, sulfur, S(═O) and S(═O)2 and containing one or more spiro atoms. Representative examples are 1,4-dioxaspiro[4.5]decanyl (e.g. 1,4-dioxaspiro[4.5]decan-2-yl, 1,4-dioxaspiro[4.5]decan-7-yl), 1,4-dioxa-8-azaspiro[4.5]decanyl (e.g. 1,4-dioxa-8-azaspiro[4.5]decan-2-yl, 1,4-dioxa-8-azaspiro[4.5]decan-8-yl), 8-azaspiro[4.5]decanyl (e.g. 8-azaspiro[4.5]decan-1-yl, 8-azaspiro[4.5]decan-8-yl), 2-azaspiro[5.5]undecanyl (e.g. 2-azaspiro[5.5]undecan-2-yl), 2,8-diazaspiro[4.5]decanyl (e.g. 2,8-diazaspiro[4.5]decan-2-yl, 2,8-diazaspiro[4.5]decan-8-yl), 2,8-diazaspiro[5.5]undecanyl (e.g. 2,8-diazaspiro[5.5]undecan-2-yl), 1,3,8-triazaspiro[4.5]decanyl (e.g. 1,3,8-triazaspiro[4.5]decan-1-yl, 1,3,8-triazaspiro[4.5]decan-3-yl, 1,3,8-triazaspiro[4.5]decan-8-yl), and the like.
The term “heteroaryl” as used herein is intended to include monocyclic heterocyclic aromatic rings containing one or more heteroatoms selected from nitrogen, oxygen, sulfur, SO and S(═O)2. Representative examples are pyrrolyl (e.g. pyrrol-1-yl, pyrrol-2-yl, pyrrol-3-yl), furanyl (e.g. furan-2-yl, furan-3-yl), thienyl (e.g. thien-2-yl, thien-3-yl), oxazolyl (e.g. oxazol-2-yl, oxazol-4-yl, oxazol-5-yl), thiazolyl (e.g. thiazol-2-yl, thiazol-4-yl, thiazol-5-yl), imidazolyl (e.g. imidazol-2-yl, imidazol-4-yl, imidazol-5-yl), pyrazolyl (e.g. pyrazol-1-yl, pyrazol-3-yl, pyrazol-5-yl), isoxazolyl (e.g. isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl), isothiazolyl (e.g. isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl), 1,2,3-triazolyl (e.g. 1,2,3-triazol-1-yl, 1,2,3-triazol-4-yl, 1,2,3-triazol-5-yl), 1,2,4-triazolyl (e.g. 1,2,4-triazol-1-yl, 1,2,4-triazol-3-yl, 1,2,4-triazol-5-yl), 1,2,3-oxadiazolyl (e.g. 1,2,3-oxadiazol-4-yl, 1,2,3-oxadiazol-5-yl), 1,2,4-oxadiazolyl (e.g. 1,2,4-oxadiazol-3-yl, 1,2,4-oxadiazol-5-yl), 1,2,5-oxadiazolyl (e.g. 1,2,5-oxadiazol-3-yl, 1,2,5-oxadiazol-4-yl), 1,3,4-oxadiazolyl (e.g. 1,3,4-oxadiazol-2-yl, 1,3,4-oxadiazol-5-yl), 1,2,3-thiadiazolyl (e.g. 1,2,3-thiadiazol-4-yl, 1,2,3-thiadiazol-5-yl), 1,2,4-thiadiazolyl (e.g. 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl), 1,2,5-thiadiazolyl (e.g. 1,2,5-thiadiazol-3-yl, 1,2,5-thiadiazol-4-yl), 1,3,4-thiadiazolyl (e.g. 1,3,4-thiadiazol-2-yl, 1,3,4-thiadiazol-5-yl), tetrazolyl (e.g. tetrazol-1-yl, tetrazol-5-yl), pyranyl (e.g. pyran-2-yl), pyridinyl (e.g. pyridine-2-yl, pyridine-3-yl, pyridine-4-yl), pyridazinyl (e.g. pyridazin-2-yl, pyridazin-3-yl), pyrimidinyl (e.g. pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl), pyrazinyl, 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl, thiadiazinyl, azepinyl, azecinyl, and the like. Heteroaryl is also intended to include bicyclic heterocyclic aromatic rings containing one or more heteroatoms selected from nitrogen, oxygen, sulfur, S(═O) and S(═O)2. Representative examples are indolyl (e.g. indol-1-yl, indol-2-yl, indol-3-yl, indol-5-yl), isoindolyl, benzofuranyl (e.g. benzo[b]furan-2-yl, benzo[b]furan-3-yl, benzo[b]furan-5-yl, benzo[c]furan-2-yl, benzo[c]furan-3-yl, benzo[c]furan-5-yl), benzothienyl (e.g. benzo[b]thien-2-yl, benzo[b]thien-3-yl, benzo[b]thien-5-yl, benzo[c]thien-2-yl, benzo[c]thien-3-yl, benzo[c]thien-5-yl), indazolyl (e.g. indazol-1-yl, indazol-3-yl, indazol-5-yl), indolizinyl (e.g. indolizin-1-yl, indolizin-3-yl), benzopyranyl (e.g. benzo[b]pyran-3-yl, benzo[b]pyran-6-yl, benzo[c]pyran-1-yl, benzo[c]pyran-7-yl), benzimidazolyl (e.g. benzimidazol-1-yl, benzimidazol-2-yl, benzimidazol-5-yl), benzothiazolyl (e.g. benzothiazol-2-yl, benzothiazol-5-yl), benzisothiazolyl, benzoxazolyl, benzisoxazolyl, benzoxazinyl, benzotriazolyl, naphthyridinyl (e.g. 1,8-naphthyridin-2-yl, 1,7-naphthyridin-2-yl, 1,6-naphthyridin-2-yl), phthalazinyl (e.g. phthalazin-1-yl, phthalazin-5-yl), pteridinyl, purinyl (e.g. purin-2-yl, purin-6-yl, purin-7-yl, purin-8-yl, purin-9-yl), quinazolinyl (e.g. quinazolin-2-yl, quinazolin-4-yl, quinazolin-6-yl), cinnolinyl, quinoliny (e.g. quinolin-2-yl, quinolin-3-yl, quinolin-4-yl, quinolin-6-yl), isoquinolinyl (e.g. isoquinolin-1-yl, isoquinolin-3-yl, isoquinolin-4-yl), quinoxalinyl (e.g. quinoxalin-2-yl, quinoxalin-5-yl), pyrrolopyridinyl (e.g. pyrrolo[2,3-b]pyridinyl, pyrrolo[2,3-c]pyridinyl, pyrrolo[3,2-c]pyridinyl), furopyridinyl (e.g. furo[2,3-b]pyridinyl, furo[2,3-c]pyridinyl, furo[3,2-c]pyridinyl), thienopyridinyl (e.g. thieno[2,3-b]pyridinyl, thieno[2,3-c]pyridinyl, thieno[3,2-c]pyridinyl), imidazopyridinyl (e.g. imidazo[4,5-b]pyridinyl, imidazo[4,5-c]pyridinyl, imidazo[1,5-a]pyridinyl, imidazo[1,2-a]pyridinyl), imidazopyrimidinyl (e.g. imidazo[1,2-a]pyrimidinyl, imidazo[3,4-a]pyrimidinyl), pyrazolopyridinyl (e.g. pyrazolo[3,4-b]pyridinyl, pyrazolo[3,4-c]pyridinyl, pyrazolo[1,5-a]pyridinyl), pyrazolopyrimidinyl (e.g. pyrazolo[1,5-a]pyrimidinyl, pyrazolo[3,4-d]pyrimidinyl), thiazolopyridinyl (e.g. thiazolo[3,2-d]pyridinyl), thiazolopyrimidinyl (e.g. thiazolo[5,4-d]pyrimidinyl), imdazothiazolyl (e.g. imidazo[2,1-b]thiazolyl), triazolopyridinyl (e.g. triazolo[4,5-b]pyridinyl), triazolopyrimidinyl (e.g. 8-azapurinyl), and the like. Heteroaryl is also intended to include polycyclic heterocyclic aromatic rings containing one or more heteroatoms selected from nitrogen, oxygen, sulfur, S(═O) and S(═O)2. Representative examples are carbazolyl (e.g. carbazol-2-yl, carbazol-3-yl, carbazol-9-yl), phenoxazinyl (e.g. phenoxazin-10-yl), phenazinyl (e.g. phenazin-5-yl), acridinyl (e.g. acridin-9-yl, acridin-10-yl), phenothiazinyl (e.g. phenothiazin-10-yl), carbolinyl (e.g. pyrido[3,4-b]indol-1-yl, pyrido[3,4-b]indol-3-yl), phenanthrolinyl (e.g. phenanthrolin-5-yl), and the like. Heteroaryl is also intended to include partially saturated monocyclic, bicyclic or polycyclic heterocyclic rings containing one or more heteroatoms selected from nitrogen, oxygen, sulfur, S(═O) and S(═O)2. Representative examples are pyrrolinyl, pyrazolinyl, imidazolinyl (e.g. 4,5-dihydroimidazol-2-yl, 4,5-dihydroimidazol-1-yl), indolinyl (e.g. 2,3-dihydroindol-1-yl, 2,3-dihydroindol-5-yl), dihydrobenzofuranyl (e.g. 2,3-dihydrobenzo[b]furan-2-yl, 2,3-dihydrobenzo[b]furan-4-yl), dihydrobenzothienyl (e.g. 2,3-dihydrobenzo[b]thien-2-yl, 2,3-dihydrobenzo[b]thien-5-yl), 4,5,6,7-tetrahydrobenzo[b]furan-5-yl), dihydrobenzopyranyl (e.g. 3,4-dihydrobenzo[b]pyran-3-yl, 3,4-dihydrobenzo[b]pyran-6-yl, 3,4-dihydrobenzo-[c]pyran-1-yl, dihydrobenzo[c]pyran-7-yl), oxazolinyl (e.g. 4,5-dihydrooxazol-2-yl, 4,5-dihydrooxazol-4-yl, 4,5-dihydrooxazol-5-yl), isoxazolinyl, oxazepinyl, tetrahydroindazolyl (e.g. 4,5,6,7-tetrahydroindazol-1-yl, 4,5,6,7-tetrahydroindazol-3-yl, 4,5,6,7-tetrahydroindazol-4-yl, 4,5,6,7-tetrahydroindazol-6-yl), tetrahydrobenzimidazolyl (e.g. 4,5,6,7-tetrahydrobenzimidazol-1-yl, 4,5,6,7-tetrahydrobenzimidazol-5-yl), tetrahydroimidazo[4,5-c]pyridyl (e.g. 4,5,6,7-tetrahydroimidazo[4,5-c]pyrid-1-yl, 4,5,6,7-tetrahydroimidazo[4,5-c]pyrid-5-yl, 4,5,6,7-tetrahydroimidazo[4,5-c]pyrid-6-yl), tetrahydroquinolinyl (e.g. 1,2,3,4-tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinolinyl), tetrahydroisoquinolinyl (e.g. 1,2,3,4-tetrahydroisoquinolinyl, 5,6,7,8-tetrahydroisoquinolinyl), tetrahydroquinoxalinyl (e.g. 1,2,3,4-tetrahydroquinoxalinyl, 5,6,7,8-tetrahydroquinoxalinyl), and the like. Heteroaryl is also intended to include partially saturated bicyclic or polycyclic heterocyclic rings containing one or more spiro atoms. Representative examples are spiro[isoquinoline-3,1′-cyclohexan]-1-yl, spiro[piperidine-4,1′-benzo[c]thiophen]-1-yl, spiro[piperidine-4,1′-benzo[c]furan]-1-yl, spiro[piperidine-4,3′-benzo[b]furan]-1-yl, spiro[piperidine-4,3′-coumarin]-1-yl, and the like.
The term “monocyclic heteroaryl” as used herein is intended to include monocyclic heterocyclic aromatic rings as defined above.
The term “bicyclic heteroaryl” as used herein is intended to include bicyclic heterocyclic aromatic rings as defined above.
The term “4 to 6 membered ring” as used herein represents a saturated 3 to 6 membered monocyclic ring, containing one nitrogen and it might contain a further heteroatom selected from oxygen, sulfur, S(═O) and S(═O)2 and it is intended to include pyrrolidinyl (e.g. pyrrolidin-1-yl, pyrrolidin-2-yl, pyrrolidin-3-yl), piperidinyl (e.g. piperidin-1-yl, piperidin-2-yl, piperidin-3-yl, piperidin-4-yl), morpholinyl (e.g. morpholin-2-yl, morpholin-3-yl, morpholin-4-yl), thiomorpholinyl (e.g. thiomorpholin-2-yl, thiomorpholin-3-yl, thiomorpholin-4-yl), 1-oxothiomorpholinyl, 1,1-dioxo-thiomorpholinyl, aziridinyl (e.g. aziridin-1-yl), azetidinyl (e.g. azetidin-1-yl, azetidin-3-yl), azetidine and the like.
The term C1-C4alkylcarbonyl as used herein refers to the radical C1-C4 alkyl-C(═O)—.
Certain of the defined terms may occur more than once in the structural formulae, and upon such occurrence each term shall be defined independently of the other.
Certain of the defined terms may occur in combinations, and it is to be understood that the first mentioned radical is a substituent on the subsequently mentioned radical, where the point of substitution, i.e. the point of attachment to another part of the molecule, is on the last mentioned of the radicals.
The term “treatment” is defined as the management and care of a patient for the purpose of combating or alleviating the disease, condition or disorder, and the term includes the administration of the active compound to prevent the onset of the symptoms or complications, or alleviating the symptoms or complications, or eliminating the disease, condition, or disorder.
The term “pharmaceutically acceptable” is defined as being suitable for administration to humans without adverse events.
The term “prodrug” is defined as a chemically modified form of the active drug, said prodrug being administered to the patient and subsequently being converted to the active drug. Techniques for development of prodrugs are well known in the art.
SUMMARY OF THE INVENTION
In one aspect of the invention substituted benzamide based inhibitors that modulate the activity of 11βHSD1 leading to altered intracellular concentrations of active glucocorticoid are provided. More specifically, the present compounds inhibit the activity of 11βHSD1 leading to decreased intracellular concentrations of active glucocorticoid. Thus, the present compounds can be used to treat disorders where a decreased level of active intracellular glucocorticoid is desirable, such as e.g. the metabolic syndrome, type 2 diabetes, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), dyslipidemia, obesity, hypertension, diabetic late complications, cardiovascular diseases, arteriosclerosis, atherosclerosis, myopathy, muscle wasting, osteoporosis, neurodegenerative and psychiatric disorders, and adverse effects of treatment or therapy with glucocorticoid receptor agonists.
One object of the present invention is to provide compounds, pharmaceutical compositions and use of compounds that modulate the activity of 11βHSD1.
The present invention furthermore relates to the use in therapy of the compounds according to the invention, to pharmaceutical compositions comprising the compounds, to the use of said compounds in the manufacture of medicaments, and to therapeutic methods comprising the administration of said compounds.


DETAILED DESCRIPTION OF THE INVENTION
The invention provides for a compound of the general formula (I):




wherein R1 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl and cyclopropyl and R2 is selected from the group consisting of a monovalent radical having one of the following formulae, wherein the symbol * denotes the point of attachment:













































or R1 and R2 together with the nitrogen to which they are attached is selected from the group consisting of one of the following formulae wherein the symbol * denotes the point of attachment:





























Q is selected is selected from the group consisting of hydroxy, carboxy, —S(═O)2R6, and S(═O)2NH2;

P is selected from the group consisting of —S(═O)2R6, carboxy and —S(═O)2NH2;

R6 is selected from the group consisting of C1-C4alkyl, phenyl, pyridine and C3-C10cycloalkyl, wherein said C1-C4alkyl, phenyl, pyridine and C3-C10cycloalkyl are optionally substituted with one or two independently selected R7;

R7 is selected from the group consisting of hydrogen, methyl, ethyl, cyclopropyl, —O—CH3, —O-cyclopropyl, —O-isopropyl, hydroxy, and halogen, wherein said methyl, ethyl, cyclopropyl, —O—CH3, —O-cyclopropyl and —O-isopropyl is optionally substituted with one substituent selected from the group consisting of hydroxy and halogen;

R4 is selected from the group consisting of hydrogen, C1-C4alkyl substituted with R12 and R13, —O—(C1-C4alkyl) substituted with R12 and R13, trifluoromethyl, —CN, halogen, —S(═O)2methyl, —S(═O)2ethyl, —S(═O)2cyclopropyl, —S(═O)2NR10R11 and —C(═O)NR10R11;

R95 is selected from the group consisting of C1-C6alkyl, phenyl, pyridine, pyrimidine, cyclopropyl, cyclobutyl and cyclohexyl, wherein said C1-C6alkyl, phenyl, pyridine, pyrimidine, cyclopropyl, cyclobutyl and cyclohexyl are optionally substituted with one or two independently selected R96;

R96 is selected from the group consisting of halogen, hydroxy, oxo, trifluoromethyl, C1-C6alkyl, and —S(═O)2methyl;

R97 is selected from the group consisting of hydrogen and C1-C6alkyl;

R12 and R13 are each independently selected from the group consisting of hydrogen, —O —(C1-C4alkyl), halogen, carboxy and hydroxy;

R5 is selected from the group consisting of hydrogen, C1-C4alkyl substituted with R16, trifluoromethyl, —CN, halogen, C1-C4alkylcarbonyl substituted with R18, —S(═O)2R17, —S(═O)2NR14R15, and —S—R17;

R10 and R11 are each independently selected from the group consisting of hydrogen, and C1-C4alkyl; or R10 and R11 together with the nitrogen to which they are attached form a 4 to 6 membered ring, wherein said C1-C4alkyl and each carbon atom in said 4 to 6 membered ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and halogen;

R14 and R15 are each independently selected from the group consisting of hydrogen, and C1-C4alkyl; or R14 and R15 together with the nitrogen to which they are attached form a 4 to 6 membered ring, wherein said C1-C4alkyl and each carbon atom in said 4 to 6 membered ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and halogen;

R16 and R18 are each independently selected from the group consisting of hydrogen, —O-methyl, methyl, cyclopropyl, halogen, —S(═O)2-methyl, —S(═O)2-ethyl, —C(═O)NH2, —C(═O)N—CH3CH3, carboxy, and hydroxy;

R17 is selected from the group consisting of hydrogen and C1-C6alkyl, wherein said C1-C6alkyl is optionally substituted with one or two substituents selected from the group consisting of hydroxy and halogen;

Y is selected from the group consisting of —X1—X2—X3—R3, —X10, —CR72R73—O—CR70R71—R3, —CR72R73—S—CR70R71—R3, —CR72R73—S(═O)2—CR70R71—R3, —CR72R73—NR25—S(═O)2—R3, —CR72R73—CR70R71—S(═O)2—R3, —CR72R73—CR70R71—O—R3, —CR72R73—CR70R71—S—R3, —CR72R73—CR70R71—NR25—R3, —O—CR44R45—S(═O)2—R3, —CR72R73—O—R3, —CR72R73—S—R3, —CR72R73—S(═O)2—R3, —CR72R73—NR25—R3, —CR72R73—S(═O)2—R3, —O—R103, —O—CR44R45, CR44R45—R103, —O—CR44R45—R103, —O—CR44R45—CR70R71—R103, —CR72R73—CR44R45—CR70R71—R103, and —CH2—R103;

X1 is selected from the group consisting of —S—, —S(═O)—, and —S(═O)2—;

X2 is absent or is selected from the group consisting of —O—, —CR44R45—, —S—, —S(═O)—, —S(═O)2— and —NR25—;

X3 is absent or is selected from the group consisting of —O—, —CR70R71—, —S—, —S(═O)—, —S(═O)2—, and —NR125—;

X10 is selected from the group consisting of C3-C10cycloalkyl substituted with R19 and phenyl substituted with R22;

each R19 is independently selected from the group consisting of —CN, —C(═O)R46, —CH(OH)—R47, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═C—R51R52, —(CR44R45)m—C≡C—R53, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, and —(CR44R45)m-aryl substituted with R56 and R57.

each R22 is independently selected from the group consisting of halogen, —CN, hydroxy, —C(═O)OH, —C(═O)R46, —CH(OH)—R47, hydroxy, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48R49, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═C—R51R52, —(CR44R45)m—C≡C—R53, —(CR44R45)m—C3-C10heterocyclyl substituted with R54, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, —(CR44R45)m-aryl substituted with R56 and R57 and —(CR44R45)m-heteroaryl substituted with R56 and R57;

R24 is selected from the group consisting of —C(═O)—R26, —S(═O)2—R27, heteroaryl substituted with R28, and aryl substituted with R29;

R25 is selected from the group consisting of hydrogen, methyl, ethyl, isobutyl, isopropyl and cyclopropyl;

R125 is selected from the group consisting of hydrogen, methyl, ethyl, isobutyl, isopropyl and cyclopropyl;

R3 is selected from the group consisting of C3-C10heterocyclyl substituted with R30 and R31, C3-C10cycloalkyl substituted with R90 and R91, aryl substituted with R30 and R31, heteroaryl substituted with R90 and R91, —C(═O)R32, —CH(OH)—R33, —(CR44R45)n—C(═O)—NR34R35, —(CR44R45), —NR36C(═O)R37, —(CR44R45)n—OR38, —(CR44R45)n—SR38, —(CR44R45)n—S(═O)2R39, —(CR44R45)n—S(═O)2NR34R35, —(CR44R45)n—NR34S(═O)2—R40, —(CR44R45)n—NR34R35, —(CR44R45)n—NR34C(═O)—NR34R35, —(CR44R45), —C═C—R41R42, and —(CR44R45), —C≡C—R43,

n is selected from the group consisting of 0, 1 and 2;

R44 and R45 are each independently selected from the group consisting hydrogen, halogen, C1-C6alkyl and C3-C10cycloalkyl, wherein said C1-C6alkyl and C3-C10cycloalkyl are optionally substituted with one or two substituents selected independently from the group consisting halogen, hydroxy and oxo; or R44 and R45 together with the carbon atom to which they are attached form a cyclopropyl or cyclobutyl ring, wherein said ring are optionally substituted with hydroxy or halogen;

R70 and R71 are each independently selected from the group consisting hydrogen, halogen, C1-C6alkyl and C3-C10cycloalkyl, wherein said C1-C6alkyl and C3-C10cycloalkyl are optionally substituted with one or two substituents selected independently from the group consisting halogen, hydroxy and oxo; or R44 and R45 together with the carbon atom to which they are attached form a cyclopropyl or cyclobutyl ring, wherein said ring are optionally substituted with hydroxy or halogen;

R72 and R73 are each independently selected from the group consisting hydrogen, halogen, C1-C6alkyl and C3-C10cycloalkyl, wherein said C1-C6alkyl and C3-C10cycloalkyl are optionally substituted with one or two substituents selected independently from the group consisting halogen, hydroxy and oxo; or R44 and R45 together with the carbon atom to which they are attached form a cyclopropyl or cyclobutyl ring, wherein said ring are optionally substituted with hydroxy or halogen;

R30, R31, R42 and R43 are each independently selected from the group consisting of hydrogen, halogen, —CN, —C(═O)OH, —C(═O)R46, —CH(OH)—R47, trifluoromethyl, hydroxy, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44—R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48R49, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═CR51R52, —(CR44R45)m—C≡C—R53, —(CR44R45)m—C3-C10heterocyclyl substituted with R54, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, —(CR44R45)m-aryl substituted with R56 and R57 and —(CR44R45)m-heteroaryl substituted with R56 and R57;

R90 and R91 are each independently selected from the group consisting of hydrogen, halogen, ═O, —CN, —C(═O)OH, —C(═O)R46, —CH(OH)—R47, hydroxy, trifluoromethyl, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48R49, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═CR51R52, —(CR44R45)m—C≡C—R53, —(CR44R45)m—C3-C10heterocyclyl substituted with R54, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, —(CR44R45)m-aryl substituted with R56 and R57 and —(CR44R45)m-heteroaryl substituted with R56 and R57;

m is 0 or 1;

R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, C3-C10heterocyclyl, C3-C10cycloalkyl, aryl and heteroaryl, wherein said C1-C6alkyl, C3-C10heterocyclyl, C3-C10cycloalkyl, aryl and heteroaryl are optionally substituted with one, two or three independently selected R58;

R34, R35, and R36 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, C3-C10cycloalkyl and heteroaryl, wherein said C1-C6alkyl, C3-C10cycloalkyl and heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl and hydroxy; or R34 and R35 together with the nitrogen to which they are attached form a 4 to 6 membered ring, wherein said 4 to 6 membered ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy or halogen;

R26, R27, R46, R47, R49, R50, R51, R52 and R53 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, heteroaryl and C3-C10cycloalkyl, wherein said C1-C6alkyl, heteroaryl and C3-C10cycloalkyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, —OCH2CH2OH, carboxy and hydroxy;

R54, R55, R56 and R57 are each independently selected from the group consisting of hydrogen, halogen, —CN, trifluoromethyl, —OCH2CH2OH, hydroxyl, C1-C6alkyl, heteroaryl and C3-C10cycloalkyl, wherein said C1-C6alkyl, heteroaryl and C3-C10cycloalkyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, —OCH2CH2OH, carboxy and hydroxy;

R48 and R49 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, tetrahydropyrane, cyclohexyl and cyclopentyl, wherein said C1-C6alkyl, tetrahydropyrane, cyclohexyl and cyclopentyl are optionally substituted with one or two substituents independently selected from the group consisting of halogen and hydroxy; or R48 and R49 together with the nitrogen to which they are attached form a 4 to 6 membered ring, wherein said 4 to 6 membered ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and halogen;

R58 are each independently selected from the group consisting of halogen, —CN, hydroxy, oxo, —C(═O)OH, —S(═O)2R59, —S—NR60R61, S(═O)2NR60R61, cyclopropyl, —OR59, C1-C6alkyl, —C(═O)NR60R61, —NR60C(═O)NR61R60, —NR60S(═O)2R59 and —NC(═O)R59;

R59 is selected from the group consisting of hydrogen, C1-C6alkyl, C3-C10cycloalkyl, aryl and heteroaryl, wherein said C1-C6alkyl, C3-C10cycloalkyl, aryl and heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, —CN and hydroxy;

R60 and R61 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, C3-C10heterocyclyl, C3-C10cycloalkyl and heteroaryl, wherein said C1-C6alkyl, C3-C10heterocyclyl, C3-C10cycloalkyl and heteroaryl are optionally substituted with one or two substituents independently selected from the group consisting of halogen and hydroxy; or R60 and R61 together with the nitrogen to which they are attached form a 4 to 6 membered ring, wherein said 4 to 6 membered ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and halogen;

R103 is selected from the group consisting of C3-C10heterocyclyl substituted with two substituents independently selected from the group consisting of R62 and R63, C3-C10cycloalkyl substituted with R30 and R31, aryl substituted with R30 and R31, heteroaryl substituted with two substituents independently selected from the group consisting of R62 and R63, —C(═O)R93, —CH(OH)—R33, —C(═O)—NR94R95, —NR36C(═O)R37, —OR38, —SR38, —S(═O)2R38, —S(═O)2NR34R35, —NR34S(═O)2—R40, —NR24R25—, —NR34C(═O)—NR34R35, —C═C substituted with R41 and R42, W and —C≡C substituted with R43;

W is selected from the group consisting of pyrrolidinone, tetrahydropyrane, 1,4-dioxane, aziridinone, azetidinone, piperidinone, thiazole, imidazole, tetrahydrofurane and oxepane;

R93 is selected from the group consisting of hydrogen, C3-C10heterocyclyl, C3-C10cycloalkyl, aryl and heteroaryl, wherein said C3-C10heterocyclyl, C3-C10cycloalkyl, aryl and heteroaryl are optionally substituted with one, two or three independently selected R58;

R94 and R95 are each independently selected from the group consisting of hydrogen, C3-C10cycloalkyl and heteroaryl, wherein said C3-C10cycloalkyl and heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl and hydroxy; or R94 and R95 together with the nitrogen to which they are attached form a 4 to 6 membered ring, wherein said 4 to 6 membered ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy or halogen;

R62 is selected from the group consisting of halogen, C1-C6alkyl, —C(═O)OH, —CH(OH)—R47, —C(═O)—NR48R49, —NR48C(═O)R46, —SR49, —S(═O)2R50, —S(═O)2NR48R40, —NR48S(═O)2R50, —NR48C(═O)—NR48R40, —C═C—R51R52, —C≡C—R53, CH2CH2OH, —CH2CH2OH, C3-C10heterocyclyl substituted with R54, C3-C10cycloalkyl substituted with R55, aryl substituted with R56 and R57 and heteroaryl substituted with R56 and R57;

R63 is selected from the group consisting of hydrogen, ═O, halogen, hydroxy, trifluoromethyl, —CN, oxo, —C(═O)OH, —S(═O)2R59, —S(═O)2NR60R61, —S(═O)NR60R61 cyclopropyl, —OR59, —SR59, —C1-C6alkyl, —C(═O)NR60R61, —NR60C(═O)NR61R60; —NR60S(═O)2R59, and —N(C═O)R59;

a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, including a racemic mixture, or any tautomeric forms.

The following aspects refer to compounds that fall within the scope of Formula I:
In one aspect, Y is —X1—X2—X3—R3.
In one aspect, X1 is selected from the group consisting of —S— and —S(═O)2—.
In one aspect, X1 is —S(═O)2—.
In one aspect, X2 is absent or is selected from the group consisting of —CR44R45— and —NR25—.
In one aspect, X2 is absent or is —CR44R45.
In one aspect, X3 is absent or is —CR70R71—.
In one aspect, —X1—X2—X3—R3 is selected from the group consisting of —S—R3, —S(═O)2—R3, —S(═O)2—NR25R3, —S(═O)2—CR44R45—R3.
In one aspect, —X1—X2—X3—R3 is selected from the group consisting of —S—R3, —S(═O)2—R3.
In one aspect, —X1—X2—X3—R3 is selected from the group consisting of —S(═O)2—NR25R3, —S(═O)2—CR44R45—R3.
In one aspect, Y is selected from the group consisting of —CR72R73—O—CR70R71—R3, —CR72R73—S—CR70R71—R3, —CR72R73—S(═O)2—CR70R71—R3, —CR72R73—NR25—S(═O)2—R3, —CR72R73—CR70R71—S(═O)2—R3, —CR72R73—CR70R71—O—R3, —CR72R73—CR70R71—S—R3, —CR72R73—CR70R71—NR25—R3, —O—CR44R45—S(═O)2—R3, —CR72R73—O—R3, —CR72R73—S—R3, —CR72R73—S(═O)2—R3, —CR72R73—NR25—R3, —CR72R73—(═O)2—R3, —O—R103, —O—CR44R45, —O—CR44R45—R103, —CR72R73—CR44R45—R103, —O—CR44R45—CR70R71—R103, —CR72R73—CR44R45—CR70R71—R103, and —CR72R73—R103.
In one aspect, Y is selected from the group consisting of —CR72R73—O—CR70R71—R3, —CR72R73—S—CR70R71—R3, —CR72R73—S(═O)2—CR70R71—R3, —CR72R73—NR25—S(═O)2—R3, —CR72R73—CR70R71—S(═O)2—R3, —CR72R73—CR70R71—O—R3 and —CR72R73—CR70R71—NR25—R3.
In one aspect, Y is selected from the group consisting of —CR72R73—O—CR70R71—R3, —CR72R73—S—CR70R71—R3, —CR72R73—CR70R71—O—R3 and —CR72R73—CR70R71—NR25—R3.
In one aspect, Y is selected from the group consisting of —CR72R73—S(═O)2—CR70R71—R3, —CR72R73—CR70R71—S(═O)2—R3 and —CR72R73—NR25—S(═O)2—R3.
In one aspect, Y is selected from the group consisting of —CR72R73—O—CR70R71—R3, —CR72R73—CR70R71—O—R3 and —CR72R73—CR70R71—NR25—R3.
In one aspect, Y is selected from the group consisting of C3-C10cycloalkyl substituted with R19 and phenyl substituted with R22.
In one aspect, Y is C3-C10cycloalkyl substituted with R19,
In one aspect, Y is phenyl substituted with R22.
In one aspect, R3 is selected from the group consisting of C3-C10heterocyclyl substituted with R30 and R31, C3-C10cycloalkyl substituted with R90 and R91, aryl substituted with R30 and R31, heteroaryl substituted with R90 and R91.
In one aspect, R3 is selected from the group consisting of —C(═O)R32, —CH(OH)—R33, —(CR44—R45)n—C(═O)—NR34R35, —(CR44R45), —NR36C(═O)R37, —(CR44R45), —OR38, —(CR44R45), —SR38, —(CR44—R45)n—S(═O)2R39, —(CR44R45)n—S(═O)2NR34R35, —(CR44R45)n—NR34S(═O)2—R40, —(CR44R45)n—NR34R35, —(CR44R45)n—NR34C(═O)—NR34R35, —(CR44R45), —C═C—R41R42 and —(CR44R45), —C≡C—R43.
In one aspect, R3 is selected from the group consisting of C3-C10heterocyclyl substituted with R30, C3-C10cycloalkyl substituted with R90, aryl substituted with R30, heteroaryl substituted with R90, —(CR44R45)n—C(═O)—NR34R35, —(CR44R45)n—NR36C(═O)R37, —(CR44R45)n—OR38, —(CR44—R45)n—S(═O)2R39, —(CR44R45)n—S(═O)2NR34R35, —(CR44R45)n—NR34S(═O)2—R40, —(CR44R45)n—NR34C(═O)—NR34R35, —(CR44R45), —C═CR41R42 and —(CR44R45), —C≡C—R43.
In one aspect, R3 is selected from the group consisting of C3-C10heterocyclyl substituted with R30, C3-C10cycloalkyl substituted with R90, aryl substituted with R30; heteroaryl substituted with R90, —C(═O)—NR34R35, —NR36C(═O)R37, —OR38, —S(═O)2R39, —S(═O)2NR34R35, —NR34S(═O)2—R40, —NR34C(═O)—NR34R35, —C═CR41R42 and —C≡C—R43.
In one aspect, R3 is selected from the group consisting of C3-C10heterocyclyl substituted with R30, C3-C10cycloalkyl substituted with R90, heteroaryl substituted with R30, —C(═O)—NR34R35, —NR36C(═O)R37, —OR38, —S(═O)2R39, —S(═O)2NR34R35, —NR34S(═O)2—R40, —NR34C(═O)—NR34R35, —C═CR41R42 and —C≡C—R43.
In one aspect, R3 is selected from the group consisting of piperidine substituted with R30, pyrrolidine substituted with R30, morpholine substituted with R30, tetrahydropyranyl substituted with R30, cyclohexyl substituted with R30, cyclopropyl substituted with R30, cyclobutyl substituted with R30, cyclopentyl substituted with R30, phenyl substituted with R30; pyridazinyl substituted with R30, pyrazinyl substituted with R30, pyridine substituted with R30, imidazolyl substituted with R30, pyrazolyl substituted with R30 and pyrimidinyl substituted with R30, isoxazolyl substituted with R30, pyridinyl substituted with R30, —C(═O)—NR34R35, —NR36C(═O)R37, —OR38, —S(═O)2R39, —S(═O)2NR34R35, —NR34S(═O)2—R40, —NR34C(═O)—NR34R35 and —C≡C—R43.
In one aspect, R3 is selected from the group consisting of piperidine substituted with R30, pyrrolidine substituted with R30, morpholine substituted with R30, tetrahydropyranyl substituted with R30, cyclohexyl substituted with R30, cyclopropyl substituted with R30, cyclobutyl substituted with R30, cyclopentyl substituted with R30, phenyl substituted with R30; pyridazinyl substituted with R30, pyrazinyl substituted with R30, pyridine substituted with R30, imidazolyl substituted with R30, pyrazolyl substituted with R30 and pyrimidinyl substituted with R30, isoxazolyl substituted with R30, pyridinyl substituted with R30.
In one aspect, R3 is selected from the group consisting of —NR36C(═O)R37, —NR34S(═O)2—R40 and —NR34C(═O)—NR34R35.
In one aspect, R3 is selected from the group consisting of —C(═O)—NR34R35, —OR38, —S(═O)2R39, —S(═O)2NR34R35 and —C≡C—R43.
In one aspect, n is selected from the group consisting of 0 or 1.
In one aspect, n is 0.
In one aspect, R103 is selected from the group consisting of —C(═O)R93, —CH(OH)—R33, —C(═O)—NR94R95, —NR36C(═O)R37, —OR38, —SR38, —S(═O)2R39, —S(═O)2NR34R35, —NR34S(═O)2—R40, —NR24R25—, —NR34C(═O)—NR34R35, —C═C substituted with R40 and R42, W and —C≡C substituted with R43.
In one aspect, R103 is selected from the group consisting of C3-C10heterocyclyl substituted with two substitutions independently selected from the group consisting of R62 and R63, C3-C10cycloalkyl substituted with R30 and R31, aryl substituted with R30 and R31, heteroaryl substituted with two substitutions independently selected from the group consisting of R62 and R63.
In one aspect, R103 is selected from the group consisting of C3-C10heterocyclyl substituted with one or two substitutions independently selected from the group consisting of R62 and R63 and heteroaryl substituted with two substitutions independently selected from the group consisting of R62 and R63.
In one aspect, R103 is selected from the group consisting of cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl substituted with R30 and R31 and phenyl substituted with R30 and R31, tetrahydropyranyl, piperidinyl, pyrrolidinyl and morpholinyl substituted with two substitutions independently selected from the group consisting of R62 and R63 and imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with two substitutions independently selected from the group consisting of R62 and R63.
In one aspect, R103 is selected from the group consisting of tetrahydropyranyl, piperidinyl, pyrrolidinyl and morpholinyl substituted with two substitutions independently selected from the group consisting of R62 and R63 and imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with two substitutions independently selected from the group consisting of R62 and R63.
In one aspect, R103 comprises at least one R62 group.
In one aspect, R103 is selected from the group consisting of C3-C10cycloalkyl substituted with R30 and R31 and aryl substituted with R30 and R31;
In one aspect, R103 is selected from the group consisting of cyclopropyl, cyclobutyl, cyclohexyl, phenyl and cyclopentyl substituted with R30 and R31;
In one aspect, R103 is selected from the group consisting of —C(═O)—NR94R95, —NR36C(═O)R37, —OR38, —SR38, —S(═O)2R39, —S(═O)2NR34R35, —NR34S(═O)2—R40, —NR34C(═O)—NR34R35, W and —C≡C substituted with R43.
In one aspect, R103 is selected from the group consisting of —C(═O)—NR94R95, —NR36C(═O)R37, —OR38, —S(═O)2R39, —S(═O)2NR34R35, —NR34S(═O)2—R40, —NR34C(═O)—NR34R35 and W.
In one aspect, R103 is selected from the group consisting of —NR36C(═O)R37, —NR34S(═O)2—R40 and —NR34C(═O)—NR34R35.
In one aspect, R1033 is selected from the group consisting of —C(═O)—NR94R95, —OR38, —S(═O)2R39, —S(═O)2NR34R35 and W.
In one aspect, R103 is W selected from the group consisting of pyrrolidinone, tetrahydropyrane, 1,4-dioxane, piperidinone, thiazole, imidazole and tetrahydrofurane.
In one aspect, R1033 is W selected from the group consisting of pyrrolidinone, tetrahydropyrane, piperidinone and imidazole.
In one aspect, R1 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl and cyclopropyl and R2 is selected from the group consisting of a monovalent radical having one of the following formulae, wherein the symbol * denotes the point of attachment:












































In one aspect, R1 is selected from the group consisting of hydrogen and methyl.
In one aspect, R1 is hydrogen.
In one aspect, R1 is methyl.
In one aspect, R2 is selected from the group consisting of:
































In one aspect, R2 is selected from the group consisting of:




















In one aspect, R2 is




In one aspect, R2 is












In one aspect, R2 is




In one aspect, R2 is




In one aspect, R2 is




In one aspect, R2 is




In one aspect, R1 and R2 together with the nitrogen to which they are attached is selected from the group consisting of:




























In one aspect, R1 and R2 together with the nitrogen to which they are attached is




In one aspect, Q is a hydroxyl group.
In one aspect, Q is a carboxy group.
In one aspect, Q is a —S(═O)2R6 group.
In one aspect, Q is selected is a —S(═O)2NH2 group.
In one aspect, P is a —S(═O)2R6 group.
In one aspect, P is a carboxy group.
In one aspect, P is a —S(═O)2NH2 group.
In one aspect, R6 is selected from the group consisting of methyl, isopropyl, ethyl, phenyl, pyridine, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said methyl, isopropyl, ethyl, phenyl, pyridine, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one or two independently selected R7.
In one aspect, R6 is selected from the group consisting of methyl, ethyl, isopropyl, phenyl, pyridine, cyclopropyl and cyclohexyl, wherein said methyl, isopropyl, phenyl, pyridine, cyclopropyl and cyclohexyl are optionally substituted with R7.
In one aspect, R7 is selected from the group consisting of hydrogen, methyl, cyclopropyl, —O—CH3, —O-cyclopropyl, —O-isopropyl, hydroxy, fluoride and chloride, wherein said methyl, ethyl, cyclopropyl, —O—CH3, —O-isopropyl and —O-cyclopropyl is optionally substituted with one substituent selected from the group consisting of hydroxy and halogen.
In one aspect, R7 is selected from the group consisting of hydrogen, methyl, cyclopropyl, —O-cyclopropyl, —O-isopropyl, hydroxy, fluoride and chloride, wherein said ethyl, cyclopropyl and —O-cyclopropyl is optionally substituted with one substituent selected from the group consisting of hydroxy and halogen.
In one aspect, R4 is selected from the group consisting of hydrogen, methyl, isopropyl, ethyl, —O-methyl, —O-isopropyl, —O-ethyl, wherein said, methyl, isopropyl, ethyl, —O-methyl, —O-isopropyl, —O-ethyl are substituted with R12 and R13, trifluoromethyl, CN, fluorine, chlorine, —S(═O)2methyl, —S(═O)2ethyl, —S(═O)2cyclopropyl, —S(═O)2NHR11 and —C(═O)NHR10.
In one aspect, R4 is selected from the group consisting of hydrogen, methyl, isopropyl, ethyl, —O-methyl, —O-isopropyl, —O-ethyl, wherein said, methyl, isopropyl, ethyl, —O-methyl, —O-isopropyl, —O-ethyl are, substituted with R12, trifluoromethyl, fluorine, chlorine, —S(═O)2(methyl)2, —S(═O)2methyl, —S(═O)2ethyl, —S(═O)2cyclopropyl, —S(═O)2Nmethyl, —S(═O)2Nisopropyl, —C(═O)Nisopropyl, —C(═O)N(methyl)2 and —C(═O)Nmethyl.
In one aspect, R4 is selected from the group consisting of hydrogen, methyl, isopropyl, —O-methyl, —O-isopropyl, —O-ethyl, trifluoromethyl, fluorine, chlorine, —S(═O)2methyl, —S(═O)2ethyl, —S(═O)2cyclopropyl, —S(═O)2Nmethyl, —S(═O)2Nisopropyl, —C(═O)Nisopropyl and —C(═O)Nmethyl.
In one aspect, R4 is in the ortho position.
In one aspect, R4 is in the meta position.
In one aspect, R95 is selected from the group consisting of methyl, isopropyl, ethyl, phenyl, pyridine, pyrimidine, cyclopropyl, cyclobutyl and cyclohexyl, wherein said ethyl, phenyl, pyridine, pyrimidine, cyclopropyl, cyclobutyl and cyclohexyl are optionally substituted with one or two independently selected R96.
In one aspect, R95 is selected from the group consisting of methyl, isopropyl, phenyl, pyridine, pyrimidine, cyclopropyl and cyclohexyl, wherein said ethyl, phenyl, pyridine, pyrimidine, cyclopropyl and cyclohexyl are optionally substituted with one R96.
In one aspect, R96 is selected from the group consisting of fluorine, chlorine, hydroxy, oxo, trifluoromethyl, methyl, isopropyl, ethyl and —S(═O)2-methyl.
In one aspect, R96 is selected from the group consisting of fluorine, chlorine, hydroxy, trifluoromethyl, methyl, isopropyl and —S(═O)2-methyl.
In one aspect, R97 is selected from the group consisting of hydrogen, methyl, isopropyl and ethyl.
In one aspect, R97 is selected from the group consisting of hydrogen, methyl and isopropyl.
In one aspect, R12 is selected from the group consisting of hydrogen, —O-(methyl, isopropyl, ethyl), fluorine, chlorine, carboxy and hydroxy.
In one aspect, R12 is selected from the group consisting of hydrogen, —O-methyl, —O-isopropyl, fluorine and hydroxy.
In one aspect, R13 is selected from the group consisting of hydrogen, —O-(methyl, isopropyl, ethyl), fluorine, chlorine, carboxy and hydroxy.
In one aspect, R13 is selected from the group consisting of hydrogen, —O-methyl, —O-isopropyl, fluorine and hydroxy.
In one aspect, R5 is selected from the group consisting of hydrogen, methyl, isopropyl, ethyl, trifluoromethyl, CN, fluorine, chlorine, acetyl, ethy, carbonyl, —S(═O)2R17, S(═O)2NR14R15, S-methyl, S-isopropyl, and S-ethyl; wherein said methyl, isopropyl, ethyl are substituted with R16 and; wherein said ethyl and carbonyl are substituted with R18.
In one aspect, R5 is selected from the group consisting of hydrogen, methyl, isopropyl, ethyl, trifluoromethyl, fluorine, chlorine, acetyl, —S(═O)2methyl, —S(═O)2 isopropyl, S(═O)2NH2, S(═O)2N(CH3)2, S-methyl, S-isopropyl, and S-ethyl; wherein said methyl, isopropyl, and ethyl are optionally substituted with fluorine or hydroxyl.
In one aspect, R5 is selected from the group consisting of hydrogen, methyl, isopropyl, trifluoromethyl, fluorine, chlorine, acetyl, —S(═O)2methyl and —S(═O)2 isopropyl.
In one aspect, R10 and R11 are each independently selected from the group consisting of hydrogen, and C1-C4alkyl.
In one aspect, R10 and R11 are each independently selected from the group consisting of hydrogen, methyl, ethyl and isopropyl.
In one aspect, R10 and R11 together with the nitrogen to which they are attached form a piperidinyl, pyrrolidinyl and morpholinyl ring, wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and fluoride.
In one aspect, R14 and R15 together with the nitrogen to which they are attached form a piperidinyl, ring, wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and fluoride.
In one aspect, R14 and R15 are each independently selected from the group consisting of hydrogen, and C1-C4alkyl.
In one aspect, R14 and R15 are each independently selected from the group consisting of hydrogen, methyl, ethyl and isopropyl.
In one aspect, R14 and R15 together with the nitrogen to which they are attached form a piperidinyl, pyrrolidinyl and morpholinyl ring wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and fluoride.
In one aspect, R14 and R15 together with the nitrogen to which they are attached form a piperidinyl ring, wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and fluoride
In one aspect, R16 is selected from the group consisting of hydrogen —O-methyl, methyl, cyclopropyl, fluorine, chlorine, —S(═O)2-methyl, —S(═O)2-ethyl, —C(═O)NH2, —C(═O)N—CH3CH3, carboxy, and hydroxy.
In one aspect, R16 is selected from the group consisting of hydrogen, methyl, cyclopropyl, fluorine, —S(═O)2-methyl, —C(═O)N—(CH3)2 and hydroxy.
In one aspect, R18 is selected from the group consisting of hydrogen —O-methyl, methyl, cyclopropyl, fluorine, chlorine, —S(═O)2-methyl, —S(═O)2-ethyl, —C(═O)NH2, —C(═O)N—CH3CH3, carboxy, and hydroxy.
In one aspect, R18 is selected from the group consisting of hydrogen, methyl, cyclopropyl, fluoride, —S(═O)2-methyl, —C(═O)N—(CH3)2 and hydroxy.
In one aspect, R17 is selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, wherein said ethyl and isopropyl is optionally substituted with one or two substituents selected from the group consisting of hydroxyl, fluorine and chlorine.
In one aspect, R17 is selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, wherein said ethyl is optionally substituted with one substituents selected from the group consisting of hydroxy and fluorine.
In one aspect, R19 is selected from the group consisting of halogen, —CN, —C(═O)R46, —CH(OH)—R47, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═C—R51R52, and —(CR44R45)m—C≡C—R53.
In one aspect, R19 is selected from the group consisting of, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, and —(CR44R45)m-aryl substituted with R56 and R57.
In one aspect, R19 is selected from the group consisting of —CN, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—OR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48C(═O)—NR48R49.
In one aspect, R19 is selected from the group consisting of, —C3-C10cycloalkyl substituted with R55, and -phenyl substituted with R56.
In one aspect, R19 is selected from the group consisting of —CN, —C(═O)—NR48R49, —NR48C(═O)R46, —OR49, —S(═O)2R50, —S(═O)2NR48R49, —NR48S(═O)2R50, —NR48C(═O)—NR48R49.
In one aspect, R22 is selected from the group consisting of halogen, —CN, hydroxy, —C(═O)OH, —C(═O)R46, —CH(OH)—R47, hydroxy, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)mR50, —(CR44R45)m—NR48R49, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44—R45)m—C═C—R51R52, —(CR44R45)m—C≡CR53.
In one aspect, R22 is selected from the group consisting of —(CR44R45)m—C3-C10heterocyclyl substituted with R54, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, —(CR44R45)m-aryl substituted with R56 and R57 and —(CR44R45)m-heteroaryl substituted with R56 and R57.
In one aspect, R22 is selected from the group consisting of fluorine, chlorine, —CN, hydroxy, —C(═O)OH, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44—R45)m—NR48C(═O)—NR48R49.
In one aspect, R22 is selected from the group consisting of —C3-C10heterocyclyl substituted with R54, —C3-C10cycloalkyl substituted with R55, -phenyl substituted with R56 and -heteroaryl substituted with R56.
In one aspect, R22 is selected from the group consisting of fluorine, chlorine, —CN, hydroxy, —C(═O)OH, —C(═O)—NR48R49, —NR48C(═O)R46, —OR49, —S(═O)2R50, —S(═O)2NR48R49, —NR48S(═O)2R50, —NR48C(═O)—NR48R49.
In one aspect, R22 is selected from the group consisting of tetrahydropyranyl, piperidinyl, pyrrolidinyl and morpholinyl substituted with R54, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl substituted with R55, -phenyl substituted with R56 and imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R56.
In one aspect, R22 is selected from the group consisting of tetrahydropyranyl, piperidinyl and morpholinyl substituted with R54, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl substituted with R55, phenyl substituted with R56 and pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R56.
In one aspect, R22 is selected from the group consisting of C═C—R51R52, —C≡C—R53 and —CH2CH2OH.
In one aspect, R24 is selected from the group consisting of —C(═O)—R26, —S(═O)2—R27, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R28, and phenyl substituted with R29.
In one aspect, R24 is selected from the group consisting of —C(═O)—R26, —S(═O)2—R27, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R28, and phenyl substituted with R29.
In one aspect, R25 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl and cyclopropyl.
In one aspect, R25 is selected from the group consisting of hydrogen, methyl, isopropyl and cyclopropyl.
In one aspect, R125 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl and cyclopropyl.
In one aspect, R125 is selected from the group consisting of hydrogen, methyl, isopropyl and cyclopropyl.
In one aspect, R44 and R45 are each independently selected from the group consisting hydrogen, fluorine, chlorine, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one substituent selected independently from the group consisting of fluorine, chlorine, hydroxy and oxo.
In one aspect, R44 and R45 are each independently selected from the group consisting hydrogen, fluorine, chlorine, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said ethyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one substituent selected independently from the group consisting of fluorine and hydroxyl.
In one aspect, R44 and R45 together with the carbon atom to which they are attached form a cyclopropyl ring, wherein said ring are optionally substituted with hydroxy or fluorine.
In one aspect, R44 and R45 together with the carbon atom to which they are attached form a cyclobutyl ring, wherein said ring are optionally substituted with hydroxy or fluorine.
In one aspect, R70 and R71 are each independently selected from the group consisting hydrogen, fluorine, chlorine, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one substituent selected independently from the group consisting of fluorine, chlorine, hydroxy and oxo.
In one aspect, R70 and R71 are each independently selected from the group consisting hydrogen, fluorine, chlorine, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said ethyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one substituent selected independently from the group consisting of fluorine and hydroxyl.
In one aspect, R70 and R71 together with the carbon atom to which they are attached form a cyclopropyl ring, wherein said ring are optionally substituted with hydroxy or fluorine.
In one aspect, R70 and R71 together with the carbon atom to which they are attached form a cyclobutyl ring, wherein said ring are optionally substituted with hydroxy or fluorine.
In one aspect, R72 and R73 are each independently selected from the group consisting hydrogen, fluorine, chlorine, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one substituent selected independently from the group consisting of fluorine, chlorine, hydroxy and oxo.
In one aspect, R72 and R73 are each independently selected from the group consisting hydrogen, fluorine, chlorine, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said ethyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one substituent selected independently from the group consisting of fluorine and hydroxyl.
In one aspect, R72 and R73 together with the carbon atom to which they are attached form a cyclopropyl ring, wherein said ring are optionally substituted with hydroxy or fluorine.
In one aspect, R72 and R73 together with the carbon atom to which they are attached form a cyclobutyl ring, wherein said ring are optionally substituted with hydroxy or fluorine.
In one aspect, R30 and R31 are each independently selected from the group consisting of hydrogen, halogen, CN, —C(═O)OH, —C(═O)R46, —CH(OH)—R47, hydroxy, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48R49, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═C—R51R52, and —(CR44R45)m—C≡C—R53.
In one aspect, R30 and R31 are each independently selected from the group consisting of hydrogen, halogen, CN, —C(═O)OH, hydroxy, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48C(═O)—NR48R49, and —(CR44R45)m—C≡C—R53.
In one aspect, R30 and R31 are each independently selected from the group consisting of hydrogen, halogen, CN, —C(═O)OH, hydroxy, —C(═O)—NR48R49, —NR48C(═O)R46, —OR49, —S(═O)2R50, —S(═O)2NR48R49, —NR48S(═O)2R50, —NR48C(═O)—NR48R49 and —C≡C—R53.
In one aspect, R30 and R31 are each independently selected from the group consisting of hydrogen, halogen, CN, —C(═O)OH, hydroxy, —C(═O)—NR48R49, —S(═O)2R50 and —S(═O)2NR48R40.
In one aspect, R30 and R31 are each independently selected from the group consisting of hydrogen, halogen, CN, —C(═O)OH, hydroxy, —NR48C(═O)R46, —OR49, —NR48S(═O)2R50 and —NR48C(═O)—NR48R40.
In one aspect, R30 and R31 are each independently selected from the group consisting of hydrogen, chlorine, fluorine, CN, —C(═O)OH, hydroxy, —NHC(═O)C1-4alkyl, —OC1-4alkyl, —OCH2CH2OH, —NHS(═O)2C1-4alkyl and —NHC(═O)—N(C1-4alkyl)2.
In one aspect, R30, R31, R42 and R43 are each independently selected from the group consisting of —(CR44R45)m—C3-C10heterocyclyl substituted with R54, —(CR44R45)m—C3-C10-cycloalkyl substituted with R55, —(CR44R45)m-aryl substituted with R56 and R57 and —(CR44R45)m-heteroaryl substituted with R56 and R57.
In one aspect, R30, R31, R42 and R43 are each independently selected from the group consisting of —C3-C10heterocyclyl substituted with R54, —C3-C10cycloalkyl substituted with R55, -phenyl substituted with R56 and R57 and -heteroaryl substituted with R56 and R57.
In one aspect, R30, R31, R42 and R43 are each independently selected from the group consisting of tetrahydropyranyl, piperidinyl, pyrrolidinyl and morpholinyl substituted with R54, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl substituted with R55, phenyl substituted with R56 and R57 and imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R56 and R57.
In one aspect, R30, R31, R42 and R43 are each independently selected from the group consisting of tetrahydropyranyl, piperidinyl, pyrrolidinyl and morpholinyl substituted with R54, cyclopropyl, cyclobutyl and cyclohexyl substituted with R55, phenyl substituted with R56 and R57 and pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R56 and R57.
In one aspect, R90 and R91 are each independently selected from the group consisting of hydrogen, halogen, ═O, —CN, —C(═O)OH, —C(═O)R46, —CH(OH)—R47, hydroxy, trifluoromethyl, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(—(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48R49, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═CR51R52, and —(CR44R45)m—C≡C—R53.
In one aspect, R90 and R91 are each independently selected from the group consisting of hydrogen, fluorine, chlorine, ═O, —CN, —C(═O)OH, hydroxy, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═CR51R52, and —(CR44R45)m—C≡C—R53.
In one aspect, R90 and R91 are each independently selected from the group consisting of hydrogen, fluorine, chlorine, —CN, —C(═O)OH, —NR48C(═O)R46, —NR48S(═O)2R50 and —NR48C(═O)—NR48R49.
In one aspect, R90 and R91 are each independently selected from the group consisting of hydrogen, fluorine, chlorine, ═O, —CN, —C(═O)OH, —C(═O)—NR48R49, —OR49, —SR49, —S(═O)2R50, —S(═O)2NR48R49, —C═CR51R52 and —C≡C—R53.
In one aspect, R90 and R91 are each independently selected from the group consisting of hydrogen, —(CR44R45)m—C3-C10heterocyclyl substituted with R54, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, —(CR44R45)m-aryl substituted with R56 and R57 and —(CR44R45)m-heteroaryl substituted with R56 and R57.
In one aspect, R90 and R91 are each independently selected from the group consisting of hydrogen, tetrahydropyranyl, piperidinyl, pyrrolidinyl and morpholinyl substituted with R54, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl substituted with R55, phenyl substituted with R56 and R57 and -imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R56 and R57.
In one aspect, R90 and R91 are each independently selected from the group consisting of hydrogen, tetrahydropyranyl, piperidinyl and morpholinyl substituted with R54, cyclopropyl, cyclobutyl and cyclohexyl substituted with R55, phenyl substituted with R56 and R57 and pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R56 and R57.
In one aspect, m is 0.
In one aspect, m is 1.
In one aspect, R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, C1-C6alkyl and C3-C10cycloalkyl, wherein said C1-C6alkyl and C3-C10cycloalkyl are optionally substituted with one or two independently selected R58.
In one aspect, R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, C1-C6alkyl and C3-C10cycloalkyl, wherein said C1-C6alkyl and C3-C10cycloalkyl are optionally substituted with one R58.
In one aspect, R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, trifluoromethyl and cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said methyl, ethyl and isopropyl, trifluoromethyl and cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one R58.
In one aspect, R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, C3-C10heterocyclyl, aryl and heteroaryl, wherein said C3-C10heterocyclyl, aryl and heteroaryl are optionally substituted with one or two independently selected R58.
In one aspect, R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, C3-C10heterocyclyl, aryl and heteroaryl, wherein said C3-C10heterocyclyl, aryl and heteroaryl are optionally substituted with one or two independently selected R58.
In one aspect, R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, phenyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl wherein said tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, phenyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl are optionally substituted with one or two independently selected R58.
In one aspect, R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, tetrahydropyranyl, piperidinyl, morpholinyl, phenyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl wherein said tetrahydropyranyl, piperidinyl, morpholinyl, phenyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one R58.
In one aspect, R34, R35, and R36 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, C3-C10cycloalkyl and heteroaryl, wherein said C1-C6alkyl, C3-C10-cycloalkyl and heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl and hydroxyl.
In one aspect, R34 and R35 together with the nitrogen to which they are attached form a piperidinyl, pyrrolidinyl and morpholinyl ring, wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy or fluorine.
In one aspect, R34, R35, and R36 are each independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three substituents independently selected from the group consisting of fluorine, methyl, ethyl and hydroxyl.
In one aspect, R34, R35, and R36 are each independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one substituent independently selected from the group consisting of fluorine, methyl, ethyl and hydroxyl.
In one aspect, R26, R27, R46, R47, R49, R50, R51, R53 and R52 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, heteroaryl and C3-C10cycloalkyl, wherein said C1-C6alkyl, heteroaryl and C3-C10cycloalkyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, —OCH2CH2OH, carboxy and hydroxy.
In one aspect, R54, R55, R56 and R57 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, heteroaryl and C3-C10cycloalkyl, wherein said C1-C6alkyl, heteroaryl and C3-C10cycloalkyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, —OCH2CH2OH, carboxy and hydroxy.
In one aspect, R26, R27, R46, R47, R49, R50, R51, R53 and R52 are each independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three substituents independently selected from the group consisting of fluorine, chlorine, methyl, ethyl, methoxy, ethoxy, —OCH2CH2OH, carboxy and hydroxy.
In one aspect, R54, R55, R56 and R57 are each independently selected from the group consisting of hydrogen, halogen, —CN, trifluoromethyl, —OCH2CH2OH, hydroxyl.
In one aspect, R54, R55, R56 and R57 are each independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three substituents independently selected from the group consisting of fluorine, chlorine methyl, ethyl, methoxy, ethoxy, —OCH2CH2OH, carboxy and hydroxy.
In one aspect, R48 is selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl wherein said methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl are optionally substituted with one or two substituents independently selected from the group consisting of fluorine and hydroxy.
In one aspect, R49 is selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl wherein said methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl are optionally substituted with one or two substituents independently selected from the group consisting of fluorine and hydroxy.
In one aspect, R49 is H and R48 is selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl wherein said methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl are optionally substituted with one or two substituents independently selected from the group consisting of fluorine and hydroxy.
In one aspect, R48 is H and R49 is selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl wherein said methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl are optionally substituted with one or two substituents independently selected from the group consisting of fluorine and hydroxy.
In one aspect, R48 and R49 together with the nitrogen to which they are attached form a piperidinyl, pyrrolidinyl and morpholinyl ring, wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and fluoride.
In one aspect, R58 are each independently selected from selected from the group consisting of halogen, —CN, hydroxy, oxo, —C(═O)OH, —S(═O)2R59, —S—NR60R61, S(═O)2NR60R61, cyclopropyl, —OR59, —SR59, C1-C6alkyl, —C(═O)NR60R61, —NR60C(═O)NR61R60, —NR60S(═O)2R59 and —NC(═O)R59.
In one aspect, R58 is selected from the group consisting of fluorine, chlorine, —CN, hydroxy, oxo, —C(═O)OH, —S(═O)2R59, —S(═O)2NR60R61, cyclopropyl, —OR59, —SR59, methyl, ethyl, isopropyl, —C(═O)NR60R61, —NR60C(═O)NR61R60, —NR60S(═O)2R59 and —NC(═O)R59.
In one aspect, R58 are each independently selected from selected from the group consisting of fluorine, chlorine, —CN, hydroxy, oxo, —C(═O)OH, —S(═O)2R59, cyclopropyl, —OR59, methyl, ethyl, isopropyl and —C(═O)NR60R61.
In one aspect, R58 are each independently selected from selected from the group consisting of —S(═O)2NR60R61, —SR59, —NR60C(═O)NR61R60, —NR60S(═O)2R59 and —NC(═O)R59.
In one aspect, R59 is selected from the group consisting of hydrogen, C1-C6alkyl and C3-C10cycloalkyl wherein said —C6alkyl, C3-C10cycloalkyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy trifluoromethyl and hydroxy.
In one aspect, R59 is selected from the group consisting of hydrogen, phenyl and heteroaryl, wherein said, phenyl and heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy and hydroxy.
In one aspect, R59 is selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, phenyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said methyl, ethyl and isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, phenyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy and hydroxy.
In one aspect, R60 are each independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, and heteroaryl, wherein said methyl, ethyl, isopropyl, tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, and heteroaryl are optionally substituted with one or two substituents independently selected from the group consisting of fluorine, chlorine and hydroxy.
In one aspect, R60 are each independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, wherein said methyl, ethyl, isopropyl and cyclopropyl are optionally substituted with one or two substituents independently selected from the group consisting of fluorine, chlorine and hydroxy.
In one aspect, R61 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, C3-C10heterocyclyl, C3-C10cycloalkyl and heteroaryl, wherein said C1-C6alkyl, C3-C10heterocyclyl, C3-C10cycloalkyl and heteroaryl are optionally substituted with one or two substituents independently selected from the group consisting of halogen and hydroxy.
In one aspect, R61 are each independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, and heteroaryl, wherein said methyl, ethyl, isopropyl, tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, and heteroaryl are optionally substituted with one or two substituents independently selected from the group consisting of fluorine, chlorine and hydroxy.
In one aspect, R93 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, phenyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, phenyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three independently selected R58.
In one aspect, R93 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, tetrahydropyranyl, piperidinyl, morpholinyl, phenyl, pyrimidinyl and pyridinyl, wherein said methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, tetrahydropyranyl, piperidinyl, morpholinyl, phenyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three independently selected R58.
In one aspect, R94 and R95 are each independently selected from the group consisting of hydrogen, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three substituents independently selected from the group consisting of fluorine, chlorine, methyl, ethyl and hydroxy.
In one aspect, R94 is hydrogen and R95 are selected from the group consisting of hydrogen, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three substituents independently selected from the group consisting of fluorine, chlorine, methyl, ethyl and hydroxy.
In one aspect, R94 and R95 together with the nitrogen to which they are attached form a piperidinyl, pyrrolidinyl and morpholinyl ring, wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy or fluorine.
In one aspect, R94 and R95 together with the nitrogen to which they are attached form a piperidinyl and pyrrolidinyl ring, wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy or fluorine.
In one aspect, R62 is selected from the group consisting of fluoride, chloride, methyl, —C(═O)OH, —CH(OH)—R47, —C(═O)—NR48R49, —NR48C(═O)R46, —SR49, —S(═O)2R50, —S(═O)2NR48R49, —NR48S(═O)2R50, —NR48C(═O)—NR48R49, —C═C—R51R52, —C≡C—R53, and CH2CH2OH, —CH2CH2OH.
In one aspect, R62 is selected from the group consisting of C3-C10heterocyclyl substituted with R54, C3-C10cycloalkyl substituted with R55, aryl substituted with R56 and R57 and heteroaryl substituted with R56 and R57.
In one aspect, R62 is selected from the group consisting of fluorine, chlorine, methyl, —CH(OH)-cyclopropyl, —C(═O)—NR48R49, —NR48C(═O)R46, —S(═O)2R50, —S(═O)2NR48R49, —NR48S(═O)2R50, —NR48C(═O)—NR48R49, CH2CH2OH, —CH2CH2OH.
In one aspect, R62 is selected from the group consisting of tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl substituted with R54, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl substituted with R55, phenyl substituted with R56 and R57 and imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl substituted with R56 and R57.
In one aspect, R63 is selected from the group consisting of hydrogen, fluoride, chloride, hydroxy, oxo, —S(═O)2R59, —S(═O)2NR60R61, —S(═O)NR60R61 cyclopropyl, —OR59, methyl, ethyl, isopropyl, —C(═O)NR60R61, —NR60C(═O)NR61R60; —NR60S(═O)2R59, and —N(C═O)R59.
In one aspect, R63 is selected from the group consisting of hydrogen, fluoride, chloride, hydroxy, oxo, —S(═O)2R59, —S(═O)2NR60R61, —S(═O)NR60R61 cyclopropyl, —OR59, methyl, ethyl, isopropyl and —C(═O)NR60R61.
In one aspect, R63 is selected from the group consisting of hydrogen, fluoride, chloride, trifluoromethyl, hydroxy, oxo, —S(═O)2cyclopropyl, —S(═O)2methyl, cyclopropyl, —OR59, methyl, ethyl and isopropyl.
In one aspect, the compound of the invention is selected from the group consisting of N-(5-Hydroxy-adamantan-2-yl)-N-methyl-3-phenethyloxy-benzamide, N-(5-Hydroxy-adamantan-2-yl)-3-phenethyloxy-benzamide, 3-Cyclohexylmethoxy-N-(5-hydroxy-adamantan-2-yl)-N-methyl-benzamide, N-(5-Hydroxy-adamantan-2-yl)-N-methyl-3-(1-methyl-butoxy)-benzamide, N-(5-Hydroxy-adamantan-2-yl)-3-methoxy-N-methyl-benzamide, N-(5-Hydroxy-adamantan-2-yl)-N-methyl-3-(2-pyridin-2-yl-ethoxy)-benzamide, N-(5-Hydroxy-adamantan-2-yl)-3-(2-pyridin-2-yl-ethoxy)-benzamide, 3-Benzyloxy-N-(5-hydroxy-adamantan-2-yl)-benzamide, N-(5-Hydroxy-adamantan-2-yl)-3-(2-morpholin-4-yl-ethoxy)-benzamide, 4-{2-[3-(5-Hydroxy-adamantan-2-ylcarbamoyl)-phenoxy]-ethyl}-piperidine-1-carboxylic acid isopropylamide, 3-[2-(1-Cyclopropanesulfonyl-piperidin-4-yl)-ethoxy]-N-(5-hydroxy-adamantan-2-yl)-benzamide, 3-(6-Chloro-pyridin-3-ylmethoxy)-N-(5-hydroxy-adamantan-2-yl)-benzamide, N-(5-Hydroxy-adamantan-2-yl)-3-(tetrahydro-pyran-4-ylmethoxy)-benzamide, N-(5-Hydroxy-adamantan-2-yl)-3-[2-(tetrahydro-pyran-4-yl)-ethoxy]-benzamide, N-(5-Hydroxy-adamantan-2-yl)-3-[2-(2-oxo-pyrrolidin-1-yl)-ethoxy]-benzamide, N-(5-Hydroxy-adamantan-2-yl)-N-methyl-3-(tetrahydro-pyran-4-yloxy)-benzamide′, (3-Hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-[3-(tetrahydro-pyran-4-ylmethoxy)-phenyl]-methanone, (3-Hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-{3-[2-(tetrahydro-pyran-4-yl)-ethoxy]-phenyl}-methanone, (3-Hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-[3-(4-hydroxy-cyclohexylmethoxy)-phenyl]-methanone.
In one embodiment the compound of the invention is an agent useful for the treatment, prevention and/or prophylaxis of any conditions, disorders and diseases wherein a modulation or an inhibition of the activity of 11βHSD1 is beneficial.
In one embodiment the compound of the invention is an agent useful for the treatment, prevention and/or prophylaxis of any conditions, disorders and diseases that are influenced by intracellular glucocorticoid levels.
In one embodiment the compound of the invention is an agent useful for the treatment, prevention and/or prophylaxis of conditions, disorders or diseases selected from the group consisting of the metabolic syndrome, insulin resistance, dyslipidemia, hypertension and obesity.
In one embodiment the compound of the invention is an agent useful for the treatment, prevention and/or prophylaxis of type 2 diabetes, impaired glucose tolerance (IGT), impaired fasting glucose (IFG).
In one embodiment the compound of the invention is an agent useful for the delaying or prevention of the progression from IGT into type 2 diabetes.
In one embodiment the compound of the invention is an agent useful for delaying or prevention of the progression of the metabolic syndrome into type 2 diabetes.
In one embodiment the compound of the invention is an agent useful for the treatment, prevention and/or prophylaxis of adverse effects of glucocorticoid receptor agonist treatment or therapy.
In one aspect of the invention, the compounds according to the invention have a IC50 value as tested as described under the heading “PHARMACOLOGICAL METHODS” below 1000 nM, in a further aspect below 500 nM, in yet a further aspect below 300 nM and in yet a further aspect below 200 nM.
The compounds of the present invention have asymmetric centers and may occur as racemates, racemic mixtures, and as individual enantiomers or diastereoisomers, with all isomeric forms being included in the present invention as well as mixtures thereof.
The present invention also encompasses pharmaceutically acceptable salts of the present compounds. Such salts include pharmaceutically acceptable acid addition salts, pharmaceutically acceptable base addition salts, pharmaceutically acceptable metal salts, ammonium and alkylated ammonium salts. Acid addition salts include salts of inorganic acids as well as organic acids. Representative examples of suitable inorganic acids include hydrochloric, hydrobromic, hydroiodic, phosphoric, sulfuric, nitric acids and the like. Representative examples of suitable organic acids include formic, acetic, trichloroacetic, trifluoroacetic, propionic, benzoic, cinnamic, citric, fumaric, glycolic, lactic, maleic, malic, malonic, mandelic, oxalic, picric, pyruvic, salicylic, succinic, methanesulfonic, ethanesulfonic, tartaric, ascorbic, pamoic, bismethylene salicylic, ethanedisulfonic, gluconic, citraconic, aspartic, stearic, palmitic, EDTA, glycolic, p-aminobenzoic, glutamic, benzenesulfonic, p-toluenesulfonic acids, sulphates, nitrates, phosphates, perchlorates, borates, acetates, benzoates, hydroxyl-naphthoates, glycerophosphates, ketoglutarates and the like. Further examples of pharmaceutically acceptable inorganic or organic acid addition salts include the pharmaceutically acceptable salts listed in J. Pharm. Sci., 66, 2 (1977), which is incorporated herein by reference. Examples of metal salts include lithium, sodium, potassium, barium, calcium, magnesium, zinc, calcium salts and the like. Examples of amines and organic amines include ammonium, methylamine, dimethylamine, trimethylamine, ethylamine, diethylamine, propylamine, butylamine, tetramethylamine, ethanolamine, diethanolamine, triethanolamine, meglumine, ethylenediamine, choline, N,N′-dibenzylethylenediamine, N-benzylphenylethylamine, N-methyl-D-glucamine, guanidine and the like. Examples of cationic amino acids include lysine, arginine, histidine and the like.
Further, some of the compounds of the present invention may form solvates with water or common organic solvents. Such solvates are encompassed within the scope of the invention. The pharmaceutically acceptable salts are prepared by reacting a compound of the present invention with 1 to 4 equivalents of a base such as sodium hydroxide, sodium methoxide, sodium hydride, potassium tert-butoxide, calcium hydroxide, magnesium hydroxide and the like, in solvents like ether, THF, methanol, tert-butanol, dioxane, isopropanol, ethanol etc. Mixtures of solvents may be used. Organic bases like lysine, arginine, diethanolamine, choline, guandine and their derivatives etc. may also be used. Alternatively, acid addition salts wherever applicable are prepared by treatment with acids such as hydrochloric acid, hydrobromic acid, nitric acid, sulfuric acid, phosphoric acid, p-toluenesulphonic acid, methanesulfonic acid, acetic acid, citric acid, maleic acid salicylic acid, hydroxynaphthoic acid, ascorbic acid, palmitic acid, succinic acid, benzoic acid, benzenesulfonic acid, tartaric acid and the like in solvents like ethyl acetate, ether, alcohols, acetone, THF, dioxane etc. Mixture of solvents may also be used.
The stereoisomers of the compounds forming part of this invention may be prepared by using reactants in their single enantiomeric form in the process wherever possible or by conducting the reaction in the presence of reagents or catalysts in their single enantiomer form or by resolving the mixture of stereoisomers by conventional methods. Some of the preferred methods include use of microbial resolution, enzymatic resolution, resolving the diastereomeric salts formed with chiral acids such as mandelic acid, camphorsulfonic acid, tartaric acid, lactic acid, and the like wherever applicable or chiral bases such as brucine, (R)- or (S)-phenylethylamine, cinchona alkaloids and their derivatives and the like. Commonly used methods are compiled by Jaques et al. in “Enantiomers, Racemates and Resolution” (Wiley Interscience, 1981). More specifically the compound of the present invention may be converted to a 1:1 mixture of diastereomeric amides by treating with chiral amines, aminoacids, aminoalcohols derived from aminoacids; conventional reaction conditions may be employed to convert acid into an amide; the diastereomers may be separated either by fractional crystallization or chromatography and the stereoisomers of compound of formula I may be prepared by hydrolysing the pure diastereomeric amide.
Various polymorphs of the compounds forming part of this invention may be prepared by crystallization of said compounds under different conditions. For example, using different solvents commonly used or their mixtures for recrystallization; crystallizations at different temperatures; various modes of cooling, ranging from very fast to very slow cooling during crystallizations. Polymorphs may also be obtained by heating or melting the compound followed by gradual or fast cooling. The presence of polymorphs may be determined by solid probe nmr spectroscopy, it spectroscopy, differential scanning calorimetry, powder X-ray diffraction or such other techniques.
The invention also encompasses prodrugs of the present compounds, which on administration undergo chemical conversion by metabolic processes before becoming active pharmacological substances. In general, such prodrugs will be functional derivatives of the present compounds, which are readily convertible in vivo into the required compound of the present invention. Conventional procedures for the selection and preparation of suitable prodrug derivatives are described, for example, in “Design of Prodrugs”, ed. H. Bundgaard, Elsevier, 1985.
It is a well known problem in drug discovery that compounds, such as enzyme inhibitors, may be very potent and selective in biochemical assays, yet be inactive in vivo. This lack of so-called bioavailability may be ascribed to a number of different factors such as lack of or poor absorption in the gut, first pass metabolism in the liver and/or poor uptake in cells. Although the factors determining bioavailability are not completely understood, there are many examples in the scientific literature—well known to those skilled in the art—of how to modify compounds, which are potent and selective in biochemical assays but show low or no activity in vivo, into drugs that are biologically active.
It is within the scope of the invention to modify the compounds of the present invention, termed the ‘original compound’, by attaching chemical groups that will improve the bioavailability of said compounds in such a way that the uptake in cells or mammals is facilitated.
Examples of said modifications, which are not intended in any way to limit the scope of the invention, include changing of one or more carboxy groups to esters (for instance methyl esters, ethyl esters, tert-butyl, acetoxymethyl, pivaloyloxymethyl esters or other acyloxy-methyl esters). Compounds of the invention, original compounds, such modified by attaching chemical groups are termed ‘modified compounds’.
The invention also encompasses active metabolites of the present compounds.
The compounds according to the invention alter, and more specifically, reduce the level of active intracellular glucocorticoid and are accordingly useful for the treatment, prevention and/or prophylaxis of disorders and diseases in which such a modulation or reduction is beneficial.
Accordingly, the present compounds may be applicable for the treatment, prevention and/or prophylaxis of the metabolic syndrome, insulin resistance, dyslipidemia, hypertension, obesity, type 2 diabetes, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), Latent Autoimmune Diabetes in the Adult (LADA), type 1 diabetes, diabetic late complications including cardiovascular diseases, cardiovascular disorders, disorders of lipid metabolism, neurodegenerative and psychiatric disorders, dysregulation of intraocular pressure including glaucoma, immune disorders, inappropriate immune responses, musculo-skeletal disorders, gastrointestinal disorders, polycystic ovarie syndrome (PCOS), reduced hair growth or other diseases, disorders or conditions that are influenced by intracellular glucocorticoid levels, adverse effects of increased blood levels of active endogenous or exogenous glucocorticoid, and any combination thereof, adverse effects of increased plasma levels of endogenous active glucocorticoid, Cushing's disease, Cushing's syndrome, adverse effects of glucocorticoid receptor agonist treatment of autoimmune diseases, adverse effects of glucocorticoid receptor agonist treatment of inflammatory diseases, adverse effects of glucocorticoid receptor agonist treatment of diseases with an inflammatory component, adverse effects of glucocorticoid receptor agonist treatment as a part of cancer chemotherapy, adverse effects of glucocorticoid receptor agonist treatment for surgical/post-surgical or other trauma, adverse effects of glucocorticoid receptor agonist therapy in the context of organ or tissue transplantation or adverse effects of glucocorticoid receptor agonist treatment in other diseases, disorders or conditions where glucocorticoid receptor agonists provide clinically beneficial effects.
More specifically the present compounds may be applicable for the treatment, prevention and/or prophylaxis of the metabolic syndrome, type 2 diabetes, diabetes as a consequence of obesity, insulin resistance, hyperglycemia, prandial hyperglycemia, hyperinsulinemia, inappropriately low insulin secretion, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), increased hepatic glucose production, type 1 diabetes, LADA, pediatric diabetes, dyslipidemia, diabetic dyslipidemia, hyperlipidemia, hypertriglyceridemia, hyperlipoproteinemia, hypercholesterolemia, decreased HDL cholesterol, impaired LDL/HDL ratio, other disorders of lipid metabolism, obesity, visceral obesity, obesity as a consequence of diabetes, increased food intake, hypertension, diabetic late complications, micro-/macroalbuminuria, nephropathy, retinopathy, neuropathy, diabetic ulcers, cardiovascular diseases, arteriosclerosis, atherosclerosis, coronary artery disease, cardiac hypertrophy, myocardial ischemia, heart insufficiency, congestional heart failure, stroke, myocardial infarction, arrythmia, decreased blood flow, erectile dysfunction (male or female), myopathy, loss of muscle tissue, muscle wasting, muscle catabolism, osteoporosis, decreased linear growth, neurodegenerative and psychiatric disorders, Alzheimers disease, neuronal death, impaired cognitive function, depression, anxiety, eating disorders, appetite regulation, migraine, epilepsia, addiction to chemical substances, disorders of intraocular pressure, glaucoma, polycystic ovary syndrome (PCOS), inappropriate immune responses, inappropriate T helper-1/T helper-2 polarisation, bacterial infections, mycobacterial infections, fungal infections, viral infections, parasitic infestations, suboptimal responses to immunizations, immune dysfunction, partial or complete baldness, or other diseases, disorders or conditions that are influenced by intracellular glucocorticoid levels and any combination thereof, adverse effects of glucocorticoid receptor agonist treatment of allergic-inflammatory diseases such as asthma and atopic dermatitis, adverse effects of glucocorticoid receptor agonist treatment of disorders of the respiratory system e.g. asthma, cystic fibrosis, emphysema, bronchitis, hypersensitivity, pneumonitis, eosinophilic pneumonias, pulmonary fibrosis, adverse effects of glucocorticoid receptor agonist treatment of inflammatory bowel disease such as Crohn's disease and ulcerative colitis; adverse effects of glucocorticoid receptor agonist treatment of disorders of the immune system, connective tissue and joints e.g. reactive arthritis, rheumatoid arthritis, Sjögren's syndrome, systemic lupus erythematosus, lupus nephritis, Henoch-Schönlein purpura, Wegener's granulomatosis, temporal arteritis, systemic sclerosis, vasculitis, sarcoidosis, dermatomyositis-polymyositis, pemphigus vulgaris; adverse effects of glucocorticoid receptor agonist treatment of endocrinological diseases such as hyperthyroidism, hypoaldosteronism, hypopituitarism; adverse effects of glucocorticoid receptor agonist treatment of hematological diseases e.g. hemolytic anemia, thrombocytopenia, paroxysmal nocturnal hemoglobinuria; adverse effects of glucocorticoid receptor agonist treatment of cancer such as spinal cord diseases, neoplastic compression of the spinal cord, brain tumours, acute lymphoblastic leukemia, Hodgkin's disease, chemotherapy-induced nausea, adverse effects of glucocorticoid receptor agonist treatment of diseases of muscle and at the neuro-muscular joint e.g. myasthenia gravis and heriditary myopathies (e.g. Duchenne muscular dystrophy), adverse effects of glucocorticoid receptor agonist treatment in the context of surgery & transplantation e.g. trauma, post-surgical stress, surgical stress, renal transplantation, liver transplantation, lung transplanttation, pancreatic islet transplantation, blood stem cell transplantation, bone marrow transplantation, heart transplantation, adrenal gland transplantation, tracheal transplanttation, intestinal transplantation, corneal transplantation, skin grafting, keratoplasty, lens implanttation and other procedures where immunosuppression with glucocorticoid receptor agonists is beneficial; adverse effects of glucocorticoid receptor agonist treatment of brain absess, nausea/vomiting, infections, hypercalcemia, adrenal hyperplasia, autoimmune hepatitis, spinal cord diseases, saccular aneurysms or adverse effects to glucocorticoid receptor agonist treatment in other diseases, disorders and conditions where glucocorticoid receptor agonists provide clinically beneficial effects.
Accordingly, in a further aspect the invention relates to a compound according to the invention for use as a pharmaceutical composition.
The invention also relates to pharmaceutical compositions comprising, as an active ingredient, at least one compound according to the invention together with one or more pharmaceutically acceptable carriers or diluents.
The pharmaceutical composition is preferably in unit dosage form, comprising from about 0.05 mg/day to about 2000 mg/day, preferably from about 1 mg/day to about 500 mg/day of a compound according to the invention.
In another embodiment, the patient is treated with a compound according to the invention for at least about 1 week, for at least about 2 weeks, for at least about 4 weeks, for at least about 2 months or for at least about 4 months.
In yet another embodiment, the pharmaceutical composition is for oral, nasal, transdermal, pulmonal or parenteral administration.
Furthermore, the invention relates to the use of a compound according to the invention for the preparation of a pharmaceutical composition for the treatment, prevention and/or prophylaxis of disorders and diseases wherein a modulation or an inhibition of the activity of 11βHSD1 is beneficial.
The invention also relates to a method for the treatment, prevention and/or prophylaxis of disorders and diseases wherein a modulation or an inhibition of the activity of 11βHSD1 is beneficial, the method comprising administering to a subject in need thereof an effective amount of a compound according to the invention.
In a preferred embodiment of the invention the present compounds are used for the preparation of a medicament for the treatment, prevention and/or prophylaxis of any diseases and conditions that are influenced by intracellular glucocorticoid levels as mentioned above.
Thus, in a preferred embodiment of the invention the present compounds are used for the preparation of a medicament for the treatment, prevention and/or prophylaxis of conditions and disorders where a decreased level of active intracellular glucocorticoid is desirable, such as the conditions and diseases mentioned above.
In yet a preferred embodiment of the invention the present compounds are used for the preparation of a medicament for the treatment, prevention and/or prophylaxis of the metabolic syndrome including insulin resistance, dyslipidemia, hypertension and obesity.
In yet another preferred embodiment of the invention the present compounds are used for the preparation of a medicament for the treatment, prevention and/or prophylaxis of type 2 diabetes, impaired glucose tolerance (IGT), impaired fasting glucose (IFG).
In yet another preferred embodiment of the invention the present compounds are used for the preparation of a pharmaceutical composition for the delaying or prevention of the progression from IGT to type 2 diabetes.
In yet another preferred embodiment of the invention the present compounds are used for the preparation of a pharmaceutical composition for the delaying or prevention of the progression of the metabolic syndrome into type 2 diabetes.
In still another preferred embodiment of the invention the present compounds are used for the preparation of a pharmaceutical composition for the treatment, prevention and/or prophylaxis of diabetic late complications including cardiovascular diseases; arteriosclerosis; atherosclerosis.
In a further preferred embodiment of the invention the present compounds are used for the preparation of a pharmaceutical composition for the treatment, prevention and/or prophylaxis of neurodegenerative and psychiatric disorders.
In yet a further preferred embodiment of the invention the present compounds are used for the preparation of a pharmaceutical composition for the treatment, prevention and/or prophylaxis of adverse effects of glucocorticoid receptor agonist treatment or therapy.
In another embodiment of the present invention, the route of administration may be any route which effectively transports a compound according to the invention to the appropriate or desired site of action, such as oral, nasal, buccal, transdermal, pulmonal, or parenteral.
In still a further aspect of the invention the present compounds are administered in combination with one or more further active substances in any suitable ratios. Such further active substances may e.g. be selected from antiobesity agents, antidiabetics, agents modifying the lipid metabolism, antihypertensive agents, glucocorticoid receptor agonists, agents for the treatment and/or prevention of complications resulting from or associated with diabetes and agents for the treatment and/or prevention of complications and disorders resulting from or associated with obesity.
Thus, in a further aspect of the invention the present compounds may be administered in combination with one or more antiobesity agents or appetite regulating agents.
Such agents may be selected from the group consisting of CART (cocaine amphetamine regulated transcript) agonists, NPY (neuropeptide Y) antagonists, MC4 (melanocortin 4) agonists, orexin antagonists, TNF (tumor necrosis factor) agonists, CRF (corticotropin releasing factor) agonists, CRF BP (corticotropin releasing factor binding protein) antagonists, urocortin agonists, β3 agonists, MSH (melanocyte-stimulating hormone) agonists, MCH (melanocyte-concentrating hormone) antagonists, CCK (cholecystokinin) agonists, serotonin re-uptake inhibitors, serotonin and noradrenaline re-uptake inhibitors, mixed serotonin and noradrenergic compounds, 5HT (serotonin) agonists, bombesin agonists, galanin antagonists, growth hormone, growth hormone releasing compounds, TRH (thyreotropin releasing hormone) agonists, UCP 2 or 3 (uncoupling protein 2 or 3) modulators, leptin agonists, DA agonists (bromocriptin, doprexin), lipase/amylase inhibitors, PPAR (peroxisome proliferator-activated receptor) modulators, RXR (retinoid X receptor) modulators, TR β agonists, AGRP (Agouti related protein) inhibitors, H3 histamine antagonists, opioid antagonists (such as naltrexone), exendin-4, GLP-1 and ciliary neurotrophic factor.
In one embodiment of the invention the antiobesity agent is leptin; dexamphetamine or amphetamine; fenfluramine or dexfenfluramine; sibutramine; orlistat; mazindol or phentermine.
Suitable antidiabetic agents include insulin, insulin analogues and derivatives such as those disclosed in EP 792 290 (Novo Nordisk A/S), e.g. NεB29-tetradecanoyl des (B30) human insulin, EP 214 826 and EP 705 275 (Novo Nordisk A/S), e.g. AspB28 human insulin, U.S. Pat. No. 5,504,188 (Eli Lilly), e.g. LysB28 ProB29 human insulin, EP 368 187 (Aventis), eg Lantus, which are all incorporated herein by reference, GLP-1 (glucagon like peptide-1) and GLP-1 derivatives such as those disclosed in WO 98/08871 to Novo Nordisk A/S, which is incorporated herein by reference as well as orally active hypoglycaemic agents.
The orally active hypoglycaemic agents preferably comprise sulphonylureas, biguanides, meglitinides, glucosidase inhibitors, glucagon antagonists such as those disclosed in WO 99/01423 to Novo Nordisk A/S and Agouron Pharmaceuticals, Inc., GLP-1 agonists, potassium channel openers such as those disclosed in WO 97/26265 and WO 99/03861 to Novo Nordisk A/S which are incorporated herein by reference, DPP-IV (dipeptidyl peptidase-IV) inhibitors, inhibitors of hepatic enzymes involved in stimulation of gluconeogenesis and/or glycogenolysis, glucose uptake modulators, compounds modifying the lipid metabolism such as antihyperlipidemic agents and antilipidemic agents as PPARα modulators, PPARδ modulators, cholesterol absorption inhibitors, HSL (hormone-sensitive lipase) inhibitors and HMG CoA inhibitors (statins), nicotinic acid, fibrates, anion exchangers, compounds lowering food intake, bile acid resins, RXR agonists and agents acting on the ATP-dependent potassium channel of the β-cells.
In one embodiment, the present compounds are administered in combination with insulin or an insulin analogue or derivative, such as NεB29-tetradecanoyl des (B30) human insulin, AspB28 human insulin, LysB28 ProB29 human insulin, Lantus®, or a mix-preparation comprising one or more of these.
In a further embodiment the present compounds are administered in combination with a sulphonylurea e.g. tolbutamide, glibenclamide, glipizide or glicazide.
In another embodiment the present compounds are administered in combination with a biguanide e.g. metformin.
In yet another embodiment the present compounds are administered in combination with a meglitinide e.g. repaglinide or senaglinide.
In still another embodiment the present compounds are administered in combination with a thiazolidinedione e.g. troglitazone, ciglitazone, pioglitazone, rosiglitazone or compounds disclosed in WO 97/41097 such as 5-[[4-[3-Methyl-4-oxo-3,4-dihydro-2-quinazolinyl]-methoxy]phenyl-methyl]thiazolidine-2,4-dione or a pharmaceutically acceptable salt thereof, preferably the potassium salt.
In yet another embodiment the present compounds may be administered in combination with the insulin sensitizers disclosed in WO 99/19313 such as (−)3-[4-[2-Phenoxazin-10-ypethoxy]phenyl]-2-ethoxypropanoic acid or a pharmaceutically acceptable salts thereof, preferably the arginine salt.
In a further embodiment the present compounds are administered in combination with an α-glucosidase inhibitor e.g. miglitol or acarbose.
In another embodiment the present compounds are administered in combination with an agent acting on the ATP-dependent potassium channel of the β-cells e.g. tolbutamide, glibenclamide, glipizide, glicazide or repaglinide.
Furthermore, the present compounds may be administered in combination with nateglinide.
In still another embodiment the present compounds are administered in combination with an antihyperlipidemic agent or antilipidemic agent e.g. cholestyramine, colestipol, clofibrate, gemfibrozil, fenofibrate, bezafibrate, tesaglitazar, EML-4156, LY-818, MK-767, atorvastatin, fluvastatin, lovastatin, pravastatin, simvastatin, acipimox, probucol, ezetimibe or dextrothyroxine.
In a further embodiment the present compounds are administered in combination with more than one of the above-mentioned compounds e.g. in combination with a sulphonylurea and metformin, a sulphonylurea and acarbose, repaglinide and metformin, insulin and a sulphonylurea, insulin and metformin, insulin, insulin and lovastatin, etc.
Further, the present compounds may be administered in combination with one or more antihypertensive agents. Examples of antihypertensive agents are β-blockers such as alprenolol, atenolol, timolol, pindolol, propranolol, metoprolol, bisoprololfumerate, esmolol, acebutelol, metoprolol, acebutolol, betaxolol, celiprolol, nebivolol, tertatolol, oxprenolol, amusolalul, carvedilol, labetalol, β2-receptor blockers e.g. S-atenolol, OPC-1085, ACE (angiotensin converting enzyme) inhibitors such as quinapril, lisinopril, enalapril, captopril, benazepril, perindopril, trandolapril, fosinopril, ramipril, cilazapril, delapril, imidapril, moexipril, spirapril, temocapril, zofenopril, S-5590, fasidotril, Hoechst-Marion Roussel: 100240 (EP 00481522), omapatrilat, gemopatrilat and GW-660511, calcium channel blockers such as nifedipine, felodipine, nicardipine, isradipine, nimodipine, diltiazem, amlodipine, nitrendipine, verapamil, lacidipine, lercanidipine, aranidipine, cilnidipine, clevidipine, azelnidipine, barnidipine, efonodipine, iasidipine, iemildipine, iercanidipine, manidipine, nilvadipine, pranidipine, furnidipine, α-blockers such as doxazosin, urapidil, prazosin, terazosin, bunazosin and OPC-28326, diuretics such as thiazides/sulphonamides (e.g. bendroflumetazide, chlorothalidone, hydrochlorothiazide and clopamide), loop-diuretics (e.g. bumetanide, furosemide and torasemide) and potassium sparing diuretics (e.g. amiloride, spironolactone), endothelin ET-A antagonists such as ABT-546, ambrisetan, atrasentan, SB-234551, CI-1034, S-0139 and YM-598, endothelin antagonists e.g. bosentan and J-104133, renin inhibitors such as aliskiren, vasopressin V1 antagonists e.g. OPC-21268, vasopressin V2 antagonists such as tolvaptan, SR-121463 and OPC-31260, B-type natriuretic peptide agonists e.g. Nesiritide, angiotensin II antagonists such as irbesartan, candesartancilexetil, losartan, valsartan, telmisartan, eprosartan, candesartan, CL-329167, eprosartan, iosartan, olmesartan, pratosartan, TA-606, and YM-358, 5-HT2 agonists e.g. fenoldopam and ketanserin, adenosine A1 antagonists such as naftopidil, N-0861 and FK-352, thromboxane A2 antagonists such as KT2-962, endopeptidase inhibitors e.g. ecadotril, nitric oxide agonists such as LP-805, dopamine D1 antagonists e.g. MYD-37, dopamine D2 agonists such as nolomirole, n-3 fatty acids e.g. omacor, prostacyclin agonists such as treprostinil, beraprost, PGE1 agonists e.g. ecraprost, Na+/K+ ATPase modulators e.g. PST-2238, Potassium channel activators e.g. KR-30450, vaccines such as PMD-3117, Indapamides, CGRP-unigene, guanylate cyclase stimulators, hydralazines, methyldopa, docarpamine, moxonidine, CoAprovel, MondoBiotech-811.
Further reference can be made to Remington: The Science and Practice of Pharmacy, 19th Edition, Gennaro, Ed., Mack Publishing Co., Easton, Pa., 1995.
Furthermore, the present compounds may be administered in combination with one or more glucocorticoid receptor agonists. Examples of such glucocorticoid receptor agonists are betametasone, dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone, beclomethasone, butixicort, clobetasol, flunisolide, flucatisone (and analogues), momethasone, triamcinolonacetonide, triamcinolonhexacetonide GW-685698, NXC-1015, NXC-1020, NXC-1021, NS-126, P-4112, P-4114, RU-24858 and T-25 series.
It should be understood that any suitable combination of the compounds according to the invention with one or more of the above-mentioned compounds and optionally one or more further pharmacologically active substances are considered to be within the scope of the present invention.
Pharmaceutical Compositions
The compounds of the present invention may be administered alone or in combination with pharmaceutically acceptable carriers or excipients, in either single or multiple doses. The pharmaceutical compositions according to the invention may be formulated with pharmaceutically acceptable carriers or diluents as well as any other known adjuvants and excipients in accordance with conventional techniques such as those disclosed in Remington: The Science and Practice of Pharmacy, 19th Edition, Gennaro, Ed., Mack Publishing Co., Easton, Pa., 1995.
The pharmaceutical compositions may be specifically formulated for administration by any suitable route such as the oral, rectal, nasal, pulmonary, topical (including buccal and sublingual), transdermal, intracisternal, intraperitoneal, vaginal and parenteral (including subcutaneous, intramuscular, intrathecal, intravenous and intradermal) route, the oral route being preferred. It will be appreciated that the preferred route will depend on the general condition and age of the subject to be treated, the nature of the condition to be treated and the active ingredient chosen.
Pharmaceutical compositions for oral administration include solid dosage forms such as hard or soft capsules, tablets, troches, dragees, pills, lozenges, powders and granules. Where appropriate, they can be prepared with coatings such as enteric coatings or they can be formulated so as to provide controlled release of the active ingredient such as sustained or prolonged release according to methods well-known in the art.
Liquid dosage forms for oral administration include solutions, emulsions, suspensions, syrups and elixirs.
Pharmaceutical compositions for parenteral administration include sterile aqueous and non-aqueous injectable solutions, dispersions, suspensions or emulsions as well as sterile powders to be reconstituted in sterile injectable solutions or dispersions prior to use. Depot injectable formulations are also contemplated as being within the scope of the present invention.
Other suitable administration forms include suppositories, sprays, ointments, crèmes, gels, inhalants, dermal patches, implants etc.
A typical oral dosage is in the range of from about 0.001 to about 100 mg/kg body weight per day, preferably from about 0.01 to about 50 mg/kg body weight per day, and more preferred from about 0.05 to about 10 mg/kg body weight per day administered in one or more dosages such as 1 to 3 dosages. The exact dosage will depend upon the frequency and mode of administration, the sex, age, weight and general condition of the subject treated, the nature and severity of the condition treated and any concomitant diseases to be treated and other factors evident to those skilled in the art.
The formulations may conveniently be presented in unit dosage form by methods known to those skilled in the art. A typical unit dosage form for oral administration one or more times per day such as 1 to 3 times per day may contain from 0.05 to about 2000 mg, e.g. from about 0.1 to about 1000 mg, from about 0.5 mg to about 500 mg., from about 1 mg to about 200 mg, e.g. about 100 mg.
For parenteral routes, such as intravenous, intrathecal, intramuscular and similar administration, typically doses are in the order of about half the dose employed for oral administration.
The compounds of this invention are generally utilized as the free substance or as a pharmaceutically acceptable salt thereof. Examples are an acid addition salt of a compound having the utility of a free base and a base addition salt of a compound having the utility of a free acid. The term “pharmaceutically acceptable salts” refers to non-toxic salts of the compounds for use according to the present invention which are generally prepared by reacting the free base with a suitable organic or inorganic acid or by reacting the acid with a suitable organic or inorganic base. When a compound for use according to the present invention, contains a free base such salts are prepared in a conventional manner by treating a solution or suspension of the compound with a chemical equivalent of a pharmaceutically acceptable acid.
When a compounds for use according to the present invention, contains a free acid such salts are prepared in a conventional manner by treating a solution or suspension of the compound with a chemical equivalent of a pharmaceutically acceptable base. Physiologically acceptable salts of a compound with a hydroxy group include the anion of said compound in combination with a suitable cation such as sodium or ammonium ion. Other salts which are not pharmaceutically acceptable may be useful in the preparation of compounds for use according to the present invention and these form a further aspect of the present invention.
For parenteral administration, solutions of the present compounds in sterile aqueous solution, aqueous propylene glycol or sesame or peanut oil may be employed. Such aqueous solutions should be suitable buffered if necessary and the liquid diluent first rendered isotonic with sufficient saline or glucose. The aqueous solutions are particularly suitable for intravenous, intramuscular, subcutaneous and intraperitoneal administration. The sterile aqueous media employed are all readily available by standard techniques known to those skilled in the art.
Suitable pharmaceutical carriers include inert solid diluents or fillers, sterile aqueous solution and various organic solvents. Examples of suitable carriers are water, salt solutions, alcohols, polyethylene glycols, polyhydroxyethoxylated castor oil, peanut oil, olive oil, syrup, phosphor-lipids, gelatine, lactose, terra alba, sucrose, cyclodextrin, amylose, magnesium stearate, talc, gelatin, agar, pectin, acacia, stearic acid or lower alkyl ethers of cellulose, silicic acid, fatty acids, fatty acid amines, fatty acid monoglycerides and diglycerides, pentaerythritol fatty acid esters, polyoxyethylene, hydroxymethylcellulose and polyvinylpyrrolidone. Similarly, the carrier or diluent may include any sustained release material known in the art, such as glyceryl monostearate or glyceryl distearate, alone or mixed with a wax. The formulations may also include wetting agents, emulsifying and suspending agents, preserving agents, sweetening agents or flavouring agents.
The pharmaceutical compositions formed by combining the compounds of the invention and the pharmaceutically acceptable carriers are then readily administered in a variety of dosage forms suitable for the disclosed routes of administration. The formulations may conveniently be presented in unit dosage form by methods known in the art of pharmacy.
Formulations of the present invention suitable for oral administration may be presented as discrete units such as capsules or tablets, each containing a predetermined amount of the active ingredient, and which may include a suitable excipient. These formulations may be in the form of powder or granules, as a solution or suspension in an aqueous or non-aqueous liquid, or as an oil-in-water or water-in-oil liquid emulsion.
Compositions intended for oral use may be prepared according to any known method, and such compositions may contain one or more agents selected from the group consisting of sweetening agents, flavouring agents, colouring agents, and preserving agents in order to provide pharmaceutically elegant and palatable preparations. Tablets may contain the active ingredient in admixture with non-toxic pharmaceutically-acceptable excipients which are suitable for the manufacture of tablets. These excipients may be for example, inert diluents, such as calcium carbonate, sodium carbonate, lactose, calcium phosphate or sodium phosphate; granulating and disintegrating agents, for example corn starch or alginic acid; binding agents, for example, starch, gelatine or acacia; and lubricating agents, for example magnesium stearate, stearic acid or talc. The tablets may be uncoated or they may be coated by known techniques to delay disintegration and absorption in the gastrointestinal tract and thereby provide a sustained action over a longer period. For example, a time delay material such as glyceryl monostearate or glyceryl distearate may be employed. They may also be coated by the techniques described in U.S. Pat. Nos. 4,356,108; 4,166,452; and 4,265,874, incorporated herein by reference, to form osmotic therapeutic tablets for controlled release.
Formulations for oral use may also be presented as hard gelatine capsules where the active ingredient is mixed with an inert solid diluent, for example, calcium carbonate, calcium phosphate or kaolin, or a soft gelatine capsule wherein the active ingredient is mixed with water or an oil medium, for example peanut oil, liquid paraffin, or olive oil.
Aqueous suspensions may contain the active compounds in admixture with excipients suitable for the manufacture of aqueous suspensions. Such excipients are suspending agents, for example sodium carboxymethylcellulose, methylcellulose, hydroxypropylmethylcellulose, sodium alginate, polyvinylpyrrolidone, gum tragacanth and gum acacia; dispersing or wetting agents may be a naturally-occurring phosphatide such as lecithin, or condensation products of an alkylene oxide with fatty acids, for example polyoxyethylene stearate, or condensation products of ethylene oxide with long chain aliphatic alcohols, for example, heptadecaethyl-eneoxycetanol, or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as polyoxyethylene sorbitol monooleate, or condensation products of ethylene oxide with partial esters derived from fatty acids and hexitol anhydrides, for example polyethylene sorbitan monooleate. The aqueous suspensions may also contain one or more colouring agents, one or more flavouring agents, and one or more sweetening agents, such as sucrose or saccharin.
Oily suspensions may be formulated by suspending the active ingredient in a vegetable oil, for example arachis oil, olive oil, sesame oil or coconut oil, or in a mineral oil such as a liquid paraffin. The oily suspensions may contain a thickening agent, for example beeswax, hard paraffin or cetyl alcohol. Sweetening agents such as those set forth above, and flavouring agents may be added to provide a palatable oral preparation. These compositions may be preserved by the addition of an anti-oxidant such as ascorbic acid.
Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water provide the active compound in admixture with a dispersing or wetting agent, suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above. Additional excipients, for example, sweetening, flavouring, and colouring agents may also be present.
The pharmaceutical compositions comprising a compound for use according to the present invention may also be in the form of oil-in-water emulsions. The oily phase may be a vegetable oil, for example, olive oil or arachis oil, or a mineral oil, for example a liquid paraffin, or a mixture thereof. Suitable emulsifying agents may be naturally-occurring gums, for example gum acacia or gum tragacanth, naturally-occurring phosphatides, for example soy bean, lecithin, and esters or partial esters derived from fatty acids and hexitol anhydrides, for example sorbitan monooleate, and condensation products of said partial esters with ethylene oxide, for example polyoxyethylene sorbitan monooleate. The emulsions may also contain sweetening and flavouring agents.
Syrups and elixirs may be formulated with sweetening agents, for example glycerol, propylene glycol, sorbitol or sucrose. Such formulations may also contain a demulcent, preservative and flavouring and colouring agent. The pharmaceutical compositions may be in the form of a sterile injectable aqueous or oleaginous suspension. This suspension may be formulated according to the known methods using suitable dispersing or wetting agents and suspending agents described above. The sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parenterally-acceptable diluent or solvent, for example as a solution in 1,3-butanediol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution, and isotonic sodium chloride solution. In addition, sterile, fixed oils are conveniently employed as solvent or suspending medium. For this purpose, any bland fixed oil may be employed using synthetic mono- or diglycerides. In addition, fatty acids such as oleic acid find use in the preparation of injectables.
The compositions may also be in the form of suppositories for rectal administration of the compounds of the present invention. These compositions can be prepared by mixing the drug with a suitable non-irritating excipient which is solid at ordinary temperatures but liquid at the rectal temperature and will thus melt in the rectum to release the drug. Such materials include cocoa butter and polyethylene glycols, for example.
For topical use, creams, ointments, jellies, solutions of suspensions, etc., containing the compounds of the present invention are contemplated. For the purpose of this application, topical applications shall include mouth washes and gargles.
The compounds for use according to the present invention may also be administered in the form of liposome delivery systems, such as small unilamellar vesicles, large unilamellar vesicles, and multilamellar vesicles. Liposomes may be formed from a variety of phospholipids, such as cholesterol, stearylamine, or phosphatidylcholines.
In addition, some of the compounds for use according to the present invention may form solvates with water or common organic solvents. Such solvates are also encompassed within the scope of the present invention.
Thus, in a further embodiment, there is provided a pharmaceutical composition comprising a compound for use according to the present invention, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, and one or more pharmaceutically acceptable carriers, excipients, or diluents.
If a solid carrier is used for oral administration, the preparation may be tabletted, placed in a hard gelatine capsule in powder or pellet form or it can be in the form of a troche or lozenge. The amount of solid carrier will vary widely but will usually be from about 25 mg to about 1 g. If a liquid carrier is used, the preparation may be in the form of a syrup, emulsion, soft gelatine capsule or sterile injectable liquid such as an aqueous or non-aqueous liquid suspension or solution.
A typical tablet which may be prepared by conventional tabletting techniques may contain:













Core:



Active compound (as free compound or salt thereof)
 5.0 mg


Lactosum Ph. Eur.
67.8 mg


Cellulose, microcryst. (Avicel)
31.4 mg


Amberlite ® IRP88*
 1.0 mg


Magnesii stearas Ph. Eur.
q.s.


Coating:










Hydroxypropyl methylcellulose
approx. 
  9 mg


Mywacett 9-40 T**
approx. 
0.9 mg





*Polacrillin potassium NF, tablet disintegrant, Rohm and Haas.


**Acylated monoglyceride used as plasticizer for film coating.






The compounds of the invention may be administered to a patient which is a mammal, especially a human in need thereof. Such mammals include also animals, both domestic animals, e.g. household pets, and non-domestic animals such as wildlife.
The present invention also relate to the below methods of preparing the compounds of the invention.
The features disclosed in the foregoing description may, both separately and in any combination thereof, be material for realising the invention in diverse forms thereof.
All references, including publications, patent applications and patents, cited herein are hereby incorporated by reference to the same extent as if each reference was individually and specifically indicated to be incorporated by reference and was set forth in its entirety herein.
All headings and sub-headings are used herein for convenience only and should not be construed as limiting the invention in any way,
Any combination of the above-described elements in all possible variations thereof is encompassed by the invention unless otherwise indicated herein or otherwise clearly contradicted by context.
The terms “a” and “an” and “the” and similar referents as used in the context of describing the invention are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context.
Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate value is incorporated into the specification as if it were individually recited herein. Unless otherwise stated, all exact values provided herein are representative of corresponding approximate values (e.g., all exact exemplary values provided with respect to a particular factor or measurement can be considered to also provide a corresponding approximate measurement, modified by “about,” where appropriate).
All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context.
The use of any and all examples, or exemplary language (e.g., “such as”) provided herein, is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention unless otherwise indicated. No language in the specification should be construed as indicating any element is essential to the practice of the invention unless as much is explicitly stated.
The citation and incorporation of patent documents herein is done for convenience only and does not reflect any view of the validity, patentability and/or enforceability of such patent documents,
The description herein of any aspect or embodiment of the invention using terms such as “comprising”, “having”, “including” or “containing” with reference to an element or elements is intended to provide support for a similar aspect or embodiment of the invention that “consists of”, “consists essentially of”, or “substantially comprises” that particular element or elements, unless otherwise stated or clearly contradicted by context (e.g., a formulation described herein as comprising a particular element should be understood as also describing a formulation consisting of that element, unless otherwise stated or clearly contradicted by context).
This invention includes all modifications and equivalents of the subject matter recited in the aspects or claims presented herein to the maximum extent permitted by applicable law.
The present invention is further illustrated in the following representative examples which are, however, not intended to limit the scope of the invention in any way.
The following examples and general procedures refer to intermediate compounds and final products for general formula (I)
EXAMPLES
The following examples and general procedures refer to intermediate compounds and final products for general formula (I) identified in the specification and in the synthesis schemes. The preparation of the compounds of general formula (I) of the present invention is described in detail using the following examples. Occasionally, the reaction may not be applicable as described to each compound included within the disclosed scope of the invention. The compounds for which this occurs will be readily recognised by those skilled in the art. In these cases the reactions can be successfully performed by conventional modifications known to those skilled in the art, which is, by appropriate protection of interfering groups, by changing to other conventional reagents, or by routine modification of reaction conditions. Alternatively, other reactions disclosed herein or otherwise conventional will be applicable to the preparation of the corresponding compounds of the invention. In all preparative methods, all starting materials are known or may easily be prepared from known starting materials. The structures of the compounds are confirmed by either elemental analysis or nuclear magnetic resonance (NMR), where peaks assigned to characteristic protons in the title compounds are presented where appropriate. 1H NMR shifts (δH) are given in parts per million (ppm) down field from tetramethylsilane as internal reference standard. M.p.: is melting point and is given in ° C. and is not corrected. Column chromatography was carried out using the technique described by W. C. Still et al., J. Org. Chem. 43: 2923 (1978) on Merck silica gel 60 (Art. 9385). HPLC analyses are performed using 5 μm C18 4×250 mm column eluted with various mixtures of water and acetonitrile, flow=1 ml/min, as described in the experimental section.
Preparative HPLC: Column: 1.9×15 cm Waters XTerra RP-18. Buffer: linear gradient 5-95% MeCN in water over 15 min, 0.1% TFA, flow rate of 15 ml/min. The pooled fractions are either evaporated to dryness in vacuo, or evaporated in vacuo until the MeCN is removed, and then frozen and freeze dried.
The abbreviations as used in the examples have the following meaning:
ADDP: 1,1′-(Azodicarbonyl)dipiperidine
CDCl3: Deuterio chloroform
DCM: Dichloromethane
DEAD: 1,1′-Diethyl azodicarboxylate
DIAD: 1,1′-Disopropyl azodicarboxylate
DIC: N,N′-Diisopropylcarbodiimide
DMAP: 4-Dimethylaminopyridine
DMF: N,N-Dimethylformamide
DMSO-d6: Hexadeuterio dimethylsulfoxide
DMSO: Dimethylsulfoxide
DIPEA: Diisopropylethylamine
EDC: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
EtOAc: Ethyl acetate
HOBT: 1-Hydroxy-benzotriazole
hrs: hours
MeCN: Acetonitrile
min: minutes
NMP: N-Methylpyrrolidinone
TBAF: Tetrabutyl ammoniumfluoride
TEA: Triethylamine
TFA: Trifluoroacetic acid
THF: Tetrahydrofuran
TLC: Thin layer chromatography




By allowing an acid (I) wherein R4, R5, and Y are defined as above to be coupled with an amine (II) wherein R1 and R2 are defined as above under standard amide bond forming conditions using a coupling reagent (e.g. HOBT, EDC and DIPEA in dry DMF) affording amide (III) wherein R1, R2, R4, R5, and Y are defined as above. Amines (II) are used as single isomers of as mixtures of two isomer, therefore amides (III) are isolated as mixtures of two isomers or as single isomers.




By allowing an acid (I) wherein R4, R5, and Y are defined as above to form the corresponding acid chloride by reaction with thionyl chloride, and then reacting the acid chloride with an amine (II) wherein R1 and R2 are defined as above under basic conditions (eg. triethyl amine, DIPEA, K2CO3 and the like) in a solvent (DCM, DMF, THF, NMP and the like) affording amide (III) wherein R1, R2, R4, R5, and Y are defined as above. Amines (II) are used as single isomers of as mixtures of two isomer, therefore amides (III) are isolated as mixtures of two isomers or as single isomers.
Alternatively, the acid chloride corresponding to acid (I) wherein R4, R5, and Y are defined as above can be used directly to react with amine (II) wherein R1 and R2 are defined as above under similar basic conditions.




By allowing an alcohol (I) wherein Y is defined as above to be coupled with an benzoic acid ester (II) wherein R is a C1-C4alkyl and R4 and R5 are defined as above under standard Mitsunobu conditions using a phosphine reagent (e.g. triphenylphosphine or tributylphosphine) together with a diazocarbonyl reagent (e.g. DEAD, DIAD, ADDP) in a solvent (e.g. THF, dioxane, DCM) followed by standard alkaline hydrolysis (using a strong base such as NaH, NaOH and the like) affording acid (III) wherein R4, R5, and Y are defined as above.












IUPAC
Molecule
LC-MS (m/z)







N-(5-Hydroxy-adamantan-2-yl)-N- methyl-3-phenethyloxy-benzamide




407 (M + 1)


 


N-(5-Hydroxy-adamantan-2-yl)-3- phenethyloxy-benzamide




393 (M + 1)


 


3-Cyclohexylmethoxy-N-(5-hydroxy- adamantan-2-yl)-N-methyl-benzamide




399 (M + 1)


 


N-(5-Hydroxy-adamantan-2-yl)-N- methyl-3-(1-methyl-butoxy)-benzamide




373 (M + 1)


 


N-(5-Hydroxy-adamantan-2-yl)-3- methoxy-N-methyl-benzamide




316 (M + 1)


 


N-(5-Hydroxy-adamantan-2-yl)-N- methyl-3-(2-pyridin-2-yl-ethoxy)- benzamide




408 (M + 1)


 


N-(5-Hydroxy-adamantan-2-yl)-3-(2- pyridin-2-yl-ethoxy)-benzamide




394 (M + 1)


 


3-Benzyloxy-N-(5-hydroxy-adamantan- 2-yl)-benzamide




379 (M + 1)


 


N-(5-Hydroxy-adamantan-2-yl)-3-(2- morpholin-4-yl-ethoxy)-benzamide




402 (M + 1)


 


4-{2-[3-(5-Hydroxy-adamantan-2- ylcarbamoyl)-phenoxy]-ethyl}- piperidine-1-carboxylic acid isopropylamide




485 (M + 1)


 


3-[2-(1-Cyclopropanesulfonyl-piperidin- 4-yl)-ethoxy]-N-(5-hydroxy-adamantan- 2-yl)-benzamide




504 (M + 1)


 


3-(6-Chloro-pyridin-3-ylmethoxy)-N-(5- hydroxy-adamantan-2-yl)-benzamide




413 (M)


 


N-(5-Hydroxy-adamantan-2-yl)-3- (tetrahydro-pyran-4-ylmethoxy)- benzamide




386 (M)


 


N-(5-Hydroxy-adamantan-2-yl)-3-[2- (tetrahydro-pyran-4-yl)-ethoxy]- benzamide




400 (M)


 


N-(5-Hydroxy-adamantan-2-yl)-3-[2-(2- oxo-pyrrolidin-1-yl)-ethoxy]-benzamide




400 (M + 1)


 


N-(5-Hydroxy-adamantan-2-yl)-N- methyl-3-(tetrahydro-pyran-4-yloxy)- benzamide




387 (M + 1)


 


(3-Hydroxy-8-aza-bicyclo[3.2.1]oct-8- yl)-[3-(tetrahydro-pyran-4-ylmethoxy)- phenyl]-methanone




346 (M + 1)


 


(3-Hydroxy-8-aza-bicyclo[3.2.1]oct-8- yl)-{3-[2-(tetrahydro-pyran-4-yl)- ethoxy]-phenyl}-methanone




360 (M)


 


(3-Hydroxy-8-aza-bicyclo[3.2.1]oct-8- yl)-[3-(4-hydroxy-cyclohexylmethoxy)- phenyl]-methanone




360 (M + 1)









Example 1
Ethyl 3-cyclohexylmethoxy-benzoate
Cyclohexyl methanol (2.0 g, 17.5 mmol), ethyl 3-hydroxybenzoate (2.6 g, 15.8 mmol), tri-n-butyl phosphin (5.3 g, 26 mmol), and ADDP (6.6 g, 26 mmol) were dissolved in dry THF (100 ml) and stirred overnight at 20° C. under N2. Water (100 ml) is added, and the resulting solution is extracted with DCM (3×100 ml). The combined organic layers were washed with water (100 ml), dried (MgSO4) and evaporated. The crude mixture was purified by preparative HPLC to give 1.8 g of the title compound. LC-MS (m/z): 264 (M+2).
3-Cyclohexylmethoxy-benzoic acid
Ethyl 3-cyclohexylmethoxy benzoic acid (1.8 g, 6.7 mmol) was dissolved in ethanol (50 ml) and THF (50 ml), wereupon NaOH (4 N, 10 ml) was added, and the solution was stirred overnight at 20° C. To the reaction mixture was added HCl (2 N, 200 ml), and the resulting solution was extracted with DCM (3×100 ml). The combined organic extracts were washed with water (100 ml), dried (MgSO4) and evaporated to give 1.6 g of the title compound. LC-MS (m/z): 236 (M+2).
The following compounds were prepared by a method similar to Example 1
3-Phenethyloxy-benzoic acid
Prepared from 2-phenethylalcohol and ethyl 3-hydroxybenzoate. LC-MS (m/z): 265 (M+22 (Na)).
3-(Tetrahydro-pyran-4-ylmethoxy)-benzoic acid
Prepared from tetrahydro-2H-pyran-4-yl-methanol and ethyl 3-hydroxybenzoate.
3-[2-(Tetrahydro-pyran-4-yl)-ethoxy]-benzoic acid
Prepared from tetrahydro-2H-pyran-4-yl-ethanol and ethyl 3-hydroxybenzoate.
3-(Tetrahydro-pyran-4-yloxy)-benzoic acid
Prepared from 4-hydroxy-tetrahydropyrane and ethyl 3-hydroxybenzoate. LC-MS (m/z): 245 (M−23 (Na)).
Example 2
[4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexyl]-methanol
tert-Butyldimethylsilyl chloride (8.8 g, 58 mmol) was added to a solution of ethyl 4-hydroxycyclohexanecarboxylate (10 g, 58 mmol) and imidazole (4.3 g, 64 mmol) in DCM (300 ml), and the mixture was stirred overnight at 20° C. After washing with water (2×100 ml), the organic phase was dried (MgSO4) and evaporated to dryness. The residue was dissolved in dry THF (300 ml) and cooled to −10° C. Dibal-H (1.0 M in toluene, 174 ml, 174 mmol) was added dropwise over a period of 60 min, while the temperature was kept at −10° C. After stirring for 2 hrs the reaction was quenched by slow addition of a saturated ammonium chloride solution (30 ml). The resulting suspension was filtered, and the filtrate was concentrated in vacuo to give 13 g of the title compound as a mixture of two isomers. LC-MS (m/z): 245 (M+1).
3-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexylmethoxy]-benzoic acid
Prepared from [4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-methanol and ethyl 3-hydroxybenzoate by a method similar to Example 1.
Example 3
N-Boc-3-(2-piperidin-4-yl-ethoxy)-benzoic acid ethyl ester
N-Boc-4-piperidine ethanol (15 g, 65 mmol) and ethyl 3-hydroxybenzoate (11 g, 65 mmol) were dissolved in dry THF (750 ml) under N2. To this was added tri-n-butylphosphin (24 ml, 98 mmol) and ADDP (25 g, 98 mmol) resulting in a suspension, which was stirred overnight at 20° C. The mixture was concentrated in vacuo to  ̃100 ml, filtered, and the filtrate was evaporated with silica gel. Flash chromatography (EtOAc/heptane 1:4) afforded 24 g of the title compound. LC-MS (m/z): 401 (M+23).
Ethyl 3-(2-piperidin-4-yl-ethoxy)-benzoate
TFA (25 ml) was added to a solution of N-Boc-3-(2-piperidin-4-yl-ethoxy)-benzoic acid ethyl ester (8.5 g, 22 mmol) in DCM (100 ml). Stirring overnight followed by evaporation of the solvents afforded 10 g of the title compound as the TFA salt. LC-MS (m/z): 279 (M+1).
Ethyl 3-[2-(1-isopropylcarbamoyl-piperidin-4-yl)-ethoxy]-benzoate
Ethyl 3-(2-piperidin-4-yl-ethoxy)-benzoate (1.0 g of the TFA salt, 2.6 mmol) was dissolved in DCM (10 ml), wereupon DIPEA (1.3 ml, 7.7 mmol) and isopropyl isocyanate (0.33 g, 3.8 mmol) was added. The reaction mixture was shaken overnight at 20° C. Silica gel (10 ml) was added, and the solvent removed in vacuo. Flash chromatography (EtOAc/heptan 35:65→55:45) provided 0.67 g of the title compound. LC-MS (m/z): 364 (M+2).
3-[2-(1-Isopropylcarbamoyl-piperidin-4-yl)-ethoxy]-benzoic acid
Ethyl 3-[2-(1-isopropylcarbamoyl-piperidin-4-yl)-ethoxy]-benzoate (0.67 g, 1.8 mmol) was dissolved in ethanol (25 ml), wereupon NaOH (1 N, 10 ml) was added, and the solution was stirred overnight at 20° C. The reaction mixture was concentrated in vacuo, dissolved in HCl (1 N, 25 ml) and the resulting solution was extracted with EtOAc (3×25 ml). The combined organic extracts were dried (MgSO4) and evaporated to give 0.62 of the title compound. LC-MS (m/z): 336 (M+2).
The following compound was prepared by a method similar to Example 3 with the variation stated.
3-[2-(1-cyclopropanesulfonyl-piperidin-4-yl)-ethoxy]-benzoic acid
Prepared from N-Boc-4-piperidine ethanol and ethyl 3-hydroxybenzoate, with the exception that ethyl 3-(2-piperidin-4-yl-ethoxy)-benzoate was converted to its corresponding sulfonamide as described below before the final alkaline hydrolysis to give the title compound. LC-MS (m/z): 377 (M+23 (Na)).
Sulfonamide Formation
DIPEA (1.3 ml, 7.7 mmol) was added to a solution of ethyl 3-(2-piperidin-4-yl-ethoxy)-benzoate (1.0 g of the TFA salt, 2.6 mmol) in DCM (10 ml). After shaking for 5 min cyclopropanesulfonyl chloride (0.54 g, 3.8 mmol) was added and the reaction mixture was shaken overnight at 20° C. After addition of silica gel (10 ml) the solvent was removed in vacuo, and flash chromatography (EtOAc/heptan 30:70→50:50) gave 0.71 g of the desired sulfonamide.
Example 4
3-(6-Chloro-pyridin-3-ylmethoxy)-benzoic acid
NaH (55% suspension in mineral oil, 1.2 g, 28 mmol) was slowly added to a suspension of 2-chloro-5-chloromethylpyridine (3.0 g, 19 mmol), ethyl 3-hydroxybenzoate (3.1 g, 19 mmol), and potassium iodide (600 mg, 3.7 mmol) in DMF (20 ml). After stirring for 2 days at 20° C., water (10 ml) and NaOH (32.5%, 2 ml) was added. The dark mixture was stirred at 80° C. overnight, wereupon it was concentrated in vacuo. The residue was purified by preparative LC-MS to give 0.80 g of the title compound. LC-MS (m/z): 264 (M+1).
The following compounds were prepared by a method similar to Example 4
3-(5-Chloro-pyridin-2-yloxy)-benzoic acid
Prepared from 2,5-dichloropyridine and ethyl 3-hydroxybenzoate. 1H NMR (400 MHz, DMSO-d5) δ 13.17 (br. s., 1H), 8.22 (d, 1H), 8.00 (dd, 1H), 7.81 (dd, 1H), 7.60-7.64 (m, 1H), 7.58 (t, 1H), 7.43 (dd, 1H), 7.18 (d, 1H).
3-(6-Bromo-pyridin-3-yloxy)-benzoic acid
Prepared from 2-bromo-5-fluoropyridine and ethyl 3-hydroxybenzoate. 1H NMR (400 MHz, DMSO-d5) δ 13.12 (br. s., 1H), 8.28 (d, 1H), 7.78 (d, 1H), 7.69 (d, 1H), 7.56 (t, 1H), 7.48-7.54 (m, 2H), 7.39 (dd, 1H)
Example 5
4-Amino-1-hydroxyadamantane
Prepared as described in Tetrahedron 1968, 24, 5369
Example 6
(5-Hydroxyadamantan-2-yl)carbamic acid tert-butyl ester
Ammonium formate (10 g, 0.15 mol) was added to a solution of 5-hydroxyadamantan-2-one (4.5 g, 0.027 mol, prepared as described in Tetrahedron 1968, 24, 5369) in MeOH (50 ml). Then 10% Pd—C (500 mg) was added carefully and the solution heated under reflux for 1 h. It was then filtered through celite and to this filtrate at 0° C. was added triethylamine (11.2 ml, 0.081 mol) and Boc anhydride (7.06 g, 0.0324 mol). The solution was stirred for 4 h at 20° C. and then concentrated under reduced pressure. The residue was diluted with water and extracted with EtOAc. The organic layer was dried and concentrated to give (5-hydroxyadamantan-2-yl)carbamic acid tert-butyl ester (7 g, 96%). LC-MS (m/z): 168 (M+1).
1HNMR (300 MHz, DMSO-d5): δ 6.8 (d, 1H), 6.7 (brs, 1H), 3.45 (d, 1H), 2.0 (s, 1H), 1.75-1.95 (m, 4H), 1.5-1.7 (m, 6H), 1.35 (s, 9H), 1.25 (t, 2H).
1-Hydroxy-4-methylamino-adamantane
Lithium aluminium hydride (0.711 g, 0.018 mol) was added to a solution of (5-hydroxy-adamantan-2-yl)carbamic acid tert-butyl ester (1 g, 0.0037 mol) in THF (50 ml) at 0° C. under a nitrogen atmosphere. The slurry was heated under reflux for 5 h. It was then cooled to 0° C. and quenched with 30% NaOH solution (12 ml) and filtered. The filtrate was concentrated to give 2-methylaminoadamantan-5-ol as a white solid (0.6 g, 90%). LC-MS (m/z): 181.9 (M+1). 1HNMR (300 MHz, DMSO-d5): δ 4.3 (s, 1H), 4.2 (s, 1H), 2.4 (s, 0.7H), 2.3 (s, 0.3H), 2.2 (s, 3H), 1.8-2.0 (m, 5H), 1.5-1.6 (m, 5H), 1.4-1.5 (m, 2H), 1.2 (m, 2H).
Example 7
3-Oxo-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester
Nortropinone (10 g, 0.062 mol) was dissolved in DCM (100 ml) and triethylamine (13.5 ml, 0.13 mol) was added followed by Boc anhydride (21.8 g, 0.10 mol). The reaction mixture was stirred at 20° C. for 3 h. It was then diluted with DCM (60 ml) and washed with 1N HCl, then twice with water and finally with brine. The organic layer was dried over anhydrous sodium sulphate and was concentrated under vacuum to give 15 g (86%) of 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester. 1HNMR (300 MHz, DMSO-d5): δ 4.2 (1H, s), 2.3 (2H, brs), 2.2 (2H, d), 2.0 (2H, brs), 1.6 (2H, d), 1.4 (9H, m).
3-Hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester
NaBH4 (8.8 g, 0.23 mol) was added to a 0° C. solution of 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (35 g, 0.16 mol) in ethanol (200 ml). The reaction mixture was stirred for 45 min at 0° C., whereupon it was allowed to reach 20° C. After stirring overnigth the suspension was evaporated to dryness. EtOAc (350 ml) was added, and the precipitate was filtered off. Water (200 ml) was added to the filtrate, and the layers were separated. The aqueous layer was extracted with EtOAc (100 ml), and the combined organic layers were dried (Na2SO4) and concentrated in vacuo to afford 29.5 g of an oil, which crystallised on standing. The two isomers were separated by flash chromatography (EtOAc/heptane 1:5→1:1), affording 5 g of the title compound. LC-MS (m/z): 250 (M+23 (Na)).
(1R,3S,5S)-8-Aza-bicyclo[3.2.1]octan-3-ol
HCl (conc. 10 ml) was added to a solution of 3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (2.1 g, 9.2 mmol) in ethanol (30 ml). After stirring for 5 h the solvent was removed in vacuo to give 1.4 g of the title compound. LC-MS (m/z): 127 (M+1).
Example 8
3-Cyclohexylmethoxy-N-(5-hydroxy-adamantan-2-yl)-N-methyl-benzamide
3-Cyclohexylmethoxy-benzoic acid (300 mg, 1.3 mmol), HOBT (294 mg, 1.9 mmol), EDC (245 mg, 1.3 mmol), and 1-hydroxy-4-methylaminoadamantane (232 mg, 1.28 mmol) were suspended in DMF (2.5 ml) before DIPEA (0.44 ml, 2.6 mmol) was added. The reaction mixture was stirred at 20° C. overnight. The reaction mixture was purified directly by Preparative HPLC to give 199 mg of the title compound as a mixture of two isomers.
1H NMR (400 MHz, CDCl3) δ: 7.24-7.32 (m, 1H), 6.88-6.98 (m, 3H), 4.10-4.24 (m, 1H), 3.76 (d, 1H), 3.10 (s, 3H), 2.51 (br. s., 2H), 2.23 (br. s., 2H), 1.63-2.02 (m, 14H), 1.57 (d, 2H), 1.16-1.36 (m, 3H), 0.98-1.11 (m, 2H).
The following compounds were prepared by a method similar to Example 8.
4-{2-[3-(5-Hydroxy-adamantan-2-ylcarbamoyl)-phenoxy]-ethyl}-piperidine-1-carboxylic acid isopropylamide
Prepared from 3-[2-(1-isopropylcarbamoyl-piperidin-4-yl)-ethoxy]-benzoic acid and 4-amino-1-hydroxyadamantane. 1H NMR (400 MHz, CDCl3): δ 7.31-7.37 (m, 2H), 7.23-7.26 (m, 1H), 7.04 (dd, 1H), 6.37 (d, 1H), 4.18-4.24 (m, 1H), 4.06 (t, 2H), 3.98 (septet, 1H), 3.90 (d, 2H), 2.82 (t, 2H), 2.17-2.29 (m, 3H), 1.92-1.99 (m, 2H), 1.73-1.86 (m, 11H), 1.59 (d, 2H), 1.19-1.30 (m, 2H), 1.16 (d, 6H).
3-[2-(1-Cyclopropanesulfonyl-piperidin-4-yl)-ethoxy]-N-(5-hydroxy-adamantan-2-yl)-benzamide
Prepared from 3-[2-(1-cyclopropanesulfonyl-piperidin-4-yl)-ethoxy]-benzoic acid and 4-amino-1-hydroxyadamantane. 1H NMR (400 MHz, CDCl3): δ 7.32-7.38 (m, 2H), 7.24-7.26 (m, 1H), 7.03 (dd, 1H), 6.32 (d, 1H), 4.19-4.24 (m, 1H), 4.07 (t, 2H), 3.78-3.85 (m, 2H), 2.81 (td, 2H), 2.61 (br. s., 2H), 2.22-2.29 (m, 3H), 2.18-2.22 (m, 1H), 1.95 (d, 2H), 1.73-1.89 (m, 11H), 1.65-1.73 (m, 1H), 1.59 (d, 2H), 1.41 (dd, 1H), 1.35 (dd, 1H), 1.14-1.20 (m, 2H), 0.94-1.00 (m, 2H).
3-(6-Chloro-pyridin-3-ylmethoxy)-N-(5-hydroxy-adamantan-2-yl)-benzamide
Prepared from 3-(6-chloro-pyridin-3-ylmethoxy)-benzoic acid and 4-amino-1-hydroxyadamantane. 1H NMR (400 MHz, CDCl3): δ 8.49 (d, 1H), 7.78 (dd, 1H), 7.42-7.44 (m, 1H), 7.38 (t, 2H), 7.32 (d, 1H), 7.10 (dd, 1H), 6.32 (d, 1H), 5.12 (s, 2H), 4.19-4.24 (m, 1H), 3.13 (br. s., 2H), 2.26 (br. s., 2H), 2.21 (br. s., 1H), 1.95 (d, 2H), 1.73-1.85 (m, 6H), 1.59 (d, 2H).
N-(5-Hydroxy-adamantan-2-yl)-3-(tetrahydro-pyran-4-ylmethoxy)-benzamide
Prepared from 3-(tetrahydro-pyran-4-ylmethoxy)-benzoic acid and 4-amino-1-hydroxyadamantane. LC-MS (m/z): 386 (M+1).
N-(5-Hydroxy-adamantan-2-yl)-3-[2-(tetrahydro-pyran-4-yl)-ethoxy]-benzamide
Prepared from 3-(tetrahydro-pyran-4-ylethoxy)-benzoic acid and 4-amino-1-hydroxyadamantane. LC-MS (m/z): 400 (M).
N-(5-Hydroxy-adamantan-2-yl)-3-[2-(2-oxo-pyrrolidin-1-yl)-ethoxy]-benzamide
Prepared from pyrrolidinoneethoxy-benzoic acid and 4-amino-1-hydroxyadamantane. LC-MS (m/z): 400 (M+1).
N-(5-Hydroxy-adamantan-2-yl)-N-methyl-3-(tetrahydro-pyran-4-yloxy)-benzamide
Prepared from 3-(tetrahydro-pyran-4-yloxy)-benzoic acid and 1-hydroxy-4-methylaminoadamantane. LC-MS (m/z): 387 (M+2).
3-Hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-[3-(tetrahydro-pyran-4-ylmethoxy)-phenyl]-methanone
Prepared from 3-(tetrahydro-pyran-4-yl-methoxy)-benzoic acid and 8-aza-bicyclo[3.2.1]octan-3-ol. LC-MS (m/z): 346 (M+1).
(3-Hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-{3-[2-(tetrahydro-pyran-4-yl)-ethoxy]-phenyl}-methanone
Prepared from 3-(tetrahydro-pyran-4-yl-ethoxy)-benzoic acid and 8-aza-bicyclo[3.2.1]octan-3-01. LC-MS (m/z): 360 (M).
3-(4-Fluoro-benzyloxy)-N-(5-hydroxy-adamantan-2-yl)-benzamide
Prepared from 3-(4-fluoro-benzyloxy)-benzoic acid and 4-amino-1-hydroxyadamantane. LC-MS (m/z): 296 (M+1).
3-(5-Chloro-pyridin-2-yloxy)-N-(5-hydroxy-adamantan-2-yl)-benzamide
Prepared from 3-(5-chloro-pyridin-2-yloxy)-benzoic acid and 4-amino-1-hydroxyadamantane. 1H NMR (400 MHz, CDCl3): δ8.11 (s, 1H), 7.68 (d, 1H), 7.51-7.61 (m, 2H), 7.47 (t, 1H), 6.94 (d, 1H), 6.23-6.36 (m, 1H), 4.08-4.25 (m, 1H), 2.24 (t, 3H), 1.51-2.03 (m, 13H).
3-(6-Bromo-pyridin-3-yloxy)-N-(5-hydroxy-adamantan-2-yl)-benzamide
Prepared from 3-(6-bromo-pyridin-3-yloxy)-benzoic acid and 4-amino-1-hydroxyadamantane. LC-MS (m/z): 444 (M+1).
(3-Hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-[3-(4-hydroxy-cyclohexylmethoxy)-phenyl]-methanone
Prepared from 3-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexylmethoxy]-benzoic acid and 8-Aza-bicyclo[3.2.1]octan-3-ol by a method similar to Example 8 followed by desilylation:
Desilylation
The partly desilylated product from the coupling reaction was dissolved in dry THF (20 ml), and after addition of TBAF (1.0 M in THF, 0.83 ml) the solution was allowed to stir overnight at 20° C. Addition of citric acid (5% in water, 25 ml) and extraction with EtOAc (3×25 ml), followed by drying (MgSO4) and evaporation of the combined organic layers afforded the crude product. This was purified by preparative HPLC to give 170 mg of the title compound as a mixture of four isomers. 1H NMR (400 MHz, CDCl3): δ 7.27-7.33 (m, 1H), 6.93-7.03 (m, 3H), 4.78-4.90 (m, 1H), 4.03-4.24 (m, 2H), 3.75-3.85 (m, 2H), 2.81 (br. s., 4H), 1.07-2.36 (m, 19H).
Example 9
N-(5-Hydroxy-adamantan-2-yl)-N-methyl-3-phenethyloxy-benzamide
3-Phenethyloxy-benzoic acid (4.2 g, 17 mmol) was dissolved in thionylchloride (30 ml), and the mixture was stirred at 20° C. overnight. The solvent was removed, and 108 mg (0.41 mmol) of this acid chloride was added to a solution of 1-hydroxy-4-methylaminoadamantane (75 mg, 0.41 mmol) and DIPEA (0.14 ml, 0.83 mmol) in DCM/DMF (1:1, 4 ml). After stirring the reaction mixture at 20° C. overnight, the solution was concentrated in vacuo and purified by preparative LC-MS to give 95 mg of the title compound as a mixture of two isomers. 1H NMR (400 MHz, CDCl3): δ 7.21-7.36 (m, 6H), 6.89-7.00 (m, 3H), 4.10-4.23 (m, 3H), 3.05-3.16 (m, 5H), 2.54 (d, 2H), 2.24 (d, 1H), 1.49-2.04 (m, 11H).
The following compounds were prepared by a method similar to Example 9.
N-(5-Hydroxy-adamantan-2-yl)-3-phenethyloxy-benzamide
Prepared from 3-phenethyloxy-benzoic acid and 4-amino-1-hydroxyadamantane to give the title compound as a mixture of two isomers. 1H NMR (300 MHz, CDCl3): δ 7.20-7.39 (m, 8H), 7.13 (dd, 0.3H), 7.02 (dd, 0.7H), 6.22-6.38 (m, 1H), 4.09-4.28 (m, 3H), 3.11 (t, 2H), 2.24 (t, 2H), 1.47-2.00 (m, 9H).
3-Benzyloxy-N-(5-hydroxy-adamantan-2-yl)-benzamide
Prepared from 3-(benzyloxy)benzoic acid and 4-amino-1-hydroxyadamantane to give the title compound as a mixture of two isomers. 1H NMR (300 MHz, CDCl3): δ 7.69-7.74 (m, 1H), 7.29-7.48 (m, 7H), 7.20-7.24 (m, 0.5H), 7.09-7.13 (m, 0.5; H), 6.27 (d, 1H), 5.12 (s, 2H), 4.18-4.23 (m, 1H), 2.16-2.27 (m, 3H), 1.91-1.98 (m, 2H), 1.71-1.84 (m, 6H), 1.54-1.61 (m, 2H).
The compounds in examples 10-12 were prepared analogously as described above.
Examples 10
3-(6-Bromopyridin-3-yloxy)-N-(5-hydroxyadamantan-2-yl)benzamide




4-Dimethylamino-N-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)benzamide




4-Dimethylamino-N-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)benzamide




Pharmacological Methods

11βHSD1 Enzyme Assay

Materials

3H-cortisone and anti-rabbit Ig coated scintillation proximity assay (SPA) beads were purchased from Amersham Pharmacia Biotech, 13-NADPH was from Sigma and rabbit anti-cortisol antibodies were from Fitzgerald. An extract of yeast transformed with h-11βHSD1 (Hutt et al., FEBS Lett, 441, 25 (1998)) was used as the source of enzyme. The test compounds were dissolved in DMSO (10 mM). All dilutions were performed in a buffer containing 50 mM TRIS-HCl (Sigma Chemical Co), 4 mM EDTA (Sigma Chemical Co), 0.1% BSA (Sigma Chemical Co), 0.01% Tween-20 (Sigma Chemical Co) and 0.005% bacitracin (Novo Nordisk A/S), pH=7.4. Optiplate 96 wells plates were supplied by Packard. The amount of 3H-cortisol bound to the SPA beads was measured on TopCount NXT, Packard.
Methods
h-11βHSD1, 120 nM 3H-cortisone, 4 mM β-NADPH, antibody (1:200), serial dilutions of test compound and SPA particles (2 mg/well) were added to the wells. The reaction was initiated by mixing the different components and was allowed to proceed under shaking for 60 min at 30° C. The reaction was stopped be the addition of 10 fold excess of a stopping buffer containing 500 μM carbenoxolone and 1 μM cortisone. Data was analysed using GraphPad Prism software.
While the invention has been described and illustrated with reference to certain preferred embodiments thereof, those skilled in the art will appreciate that various changes, modifications, and substitutions can be made therein without departing from the spirit and scope of the present invention. For example, effective dosages other than the preferred dosages as set forth herein may be applicable as a consequence of variations in the responsiveness of the mammal being treated. Likewise, the specific pharmacological responses observed may vary according to and depending on the particular active compound selected or whether there are present pharmaceutical carriers, as well as the type of formulation and mode of administration employed, and such expected variations or differences in the results are contemplated in accordance with the objects and practices of the present invention. Accordingly, the invention is not to be limited as by the appended claims.
The features disclosed in the foregoing description and/or in the claims may both separately and in any combination thereof be material for realising the invention in diverse forms thereof.
Preferred features of the invention:
1. A compound of the general formula (I):




wherein R1 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl and cyclopropyl and R2 is selected from the group consisting of a monovalent radical having one of the following formulae, wherein the symbol * denotes the point of attachment:













































R1 and R2 together with the nitrogen to which they are attached is selected from the group consisting of one of the following formulae wherein the symbol * denotes the point of attachment:





























Q is selected is selected from the group consisting of hydroxy, carboxy, —S(═O)2R6, and S(═O)2NH2;

P is selected from the group consisting of —S(═O)2R6, carboxy and —S(═O)2NH2,

R6 is selected from the group consisting of C1-C4alkyl, phenyl, pyridine and C3-C10cycloalkyl, wherein said C1-C4alkyl, phenyl, pyridine and C3-C10cycloalkyl are optionally substituted with one or two independently selected R7;

R7 is selected from the group consisting of hydrogen, methyl, ethyl, cyclopropyl, —O—CH3, —O-cyclopropyl, —O-isopropyl, hydroxy, and halogen, wherein said methyl, ethyl, cyclopropyl, —O—CH3, —O-cyclopropyl and —O-isopropyl is optionally substituted with one substituent selected from the group consisting of hydroxy and halogen;

R4 is selected from the group consisting of hydrogen, C1-C4alkyl substituted with R12 and R13, —O—(C1-C4alkyl) substituted with R12 and R13, trifluoromethyl, —CN, halogen, —S(═O)2methyl, —S(═O)2ethyl, —S(═O)2cyclopropyl, —S(═O)2NR10R11 and —C(═O)NR10R11;

R95 is selected from the group consisting of C1-C6alkyl, phenyl, pyridine, pyrimidine, cyclopropyl, cyclobutyl and cyclohexyl, wherein said C1-C6alkyl, phenyl, pyridine, pyrimidine, cyclopropyl, cyclobutyl and cyclohexyl are optionally substituted with one or two independently selected R96;

R96 is selected from the group consisting of halogen, hydroxy, oxo, trifluoromethyl, C1-C6alkyl, and —S(═O)2methyl;

R97 is selected from the group consisting of hydrogen and C1-C6alkyl;

R12 and Rn are each independently selected from the group consisting of hydrogen, —O—(C1-C4alkyl), halogen, carboxy and hydroxy;

R5 is selected from the group consisting of hydrogen, C1-C4alkyl substituted with R16, trifluoromethyl, —CN, halogen, C1-C4alkylcarbonyl substituted with R18, —S(═O)2R17, —S(═O)2NR14R15, and —S—R17;

R10 and R11 are each independently selected from the group consisting of hydrogen, and C1-C4alkyl; or R10 and R11 together with the nitrogen to which they are attached form a 4 to 6 membered ring, wherein said C1-C4alkyl and each carbon atom in said 4 to 6 membered ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and halogen;

R14 and R15 are each independently selected from the group consisting of hydrogen, and C1-C4alkyl; or R14 and R15 together with the nitrogen to which they are attached form a 4 to 6 membered ring, wherein said C1-C4alkyl and each carbon atom in said 4 to 6 membered ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and halogen;

R16 and R18 are each independently selected from the group consisting of hydrogen, —O-methyl, methyl, cyclopropyl, halogen, —S(═O)2-methyl, —S(═O)2-ethyl, —C(═O)NH2, —C(═O)N—CH3CH3, carboxy, and hydroxy;

R17 is selected from the group consisting of hydrogen and C1-C6alkyl, wherein said C1-C6alkyl is optionally substituted with one or two substituents selected from the group consisting of hydroxy and halogen;

Y is selected from the group consisting of —X1—X2—X3—R3, —X10, —CR72R73—O—CR70R71—R3, —CR72R73—S—CR70R71—R3, —CR72R73—S(═O)2—CR70R71—R3, —CR72R73—NR25—S(═O)2—R3, —CR72R73—CR70R71—S(═O)2—R3, —CR72R73—CR70R71—O—R3, —CR72R73—CR70R71—S—R3, —CR72R73—CR70R71—NR25—R3, —O—CR44R45—S(═O)2—R3, —CR72R73—O—R3, —CR72R73—S—R3, —CR72R73—S(═O)2—R3, —CR72R73—NR25—R3, —CR72R73—S(═O)2—R3, —O—R103, —CR72R73—CR44R45—R103—O—CR44R45—CR70R71—R103, —CR72R73—CR44R45—CR70R71—R103, and —CH2—R103;

X1 is selected from the group consisting of —S—, —S(═O)—, and —S(═O)2—;

X2 is absent or is selected from the group consisting of —O—, —CR44R45—, —S—, —S(═O)—, —S(═O)2—and —NR25—;

X3 is absent or is selected from the group consisting of —O—, —CR70R71—, —S—, —S(═O)—, —S(═O)2—, and —NR125—;

X3 is selected from the group consisting of C3-C10cycloalkyl substituted with R19 and phenyl substituted with R22;

each R10 is independently selected from the group consisting of —CN, —C(═O)R46, —CH(OH)—R47, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═C—R51R52, —(CR44R45)m—C≡C—R53, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, and —(CR44R45)m-aryl substituted with R56 and R57.

each R22 is independently selected from the group consisting of halogen, —CN, hydroxy, —C(═O)OH, —C(═O)R46, —CH(OH)—R47, hydroxy, —(CR44R45)mC(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48R49, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═C—R51R52, —(CR44R45)m—C≡C—R53, —(CR44R45)m—C3-C10heterocyclyl substituted with R54, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, —(CR44R45)m-aryl substituted with R56 and R57 and —(CR44R45)m-heteroaryl substituted with R56 and R57;

R24 is selected from the group consisting of —C(═O)—R26, —S(═O)2—R27, heteroaryl substituted with R28, and aryl substituted with R29;

R25 is selected from the group consisting of hydrogen, methyl, ethyl, isobutyl, isopropyl and cyclopropyl;

R125 is selected from the group consisting of hydrogen, methyl, ethyl, isobutyl, isopropyl and cyclopropyl;

R3 is selected from the group consisting of C3-C10heterocyclyl substituted with R30 and R31, C3-C10cycloalkyl substituted with R90 and R91, aryl substituted with R30 and R31, heteroaryl substituted with R90 and R91, —C(═O)R32, —CH(OH)—R33, —(CR44R45)n—C(═O)—NR34R35, —(CR44R45)n—NR36C(═O)R37, —(CR44R45)n—OR38, —(CR44R45)n—SR38, —(CR44R45), —S(═O)2R39, —(CR44R45)n—S(═O)2NR34R35, —(CR44R45)n—NR34S(═O)2—R40, —(CR44R45)n—NR34R35, —(CR44R45)n—NR34C(═O)—NR34R35, —(CR44R45)n—C═C—R41R42, and —(CR44R45)n—C≡C—R43,

n is selected from the group consisting of 0, 1 and 2;

R44 and R45 are each independently selected from the group consisting hydrogen, halogen, C1-C6alkyl and C3-C10cycloalkyl, wherein said C1-C6alkyl and C3-C10cycloalkyl are optionally substituted with one or two substituents selected independently from the group consisting halogen, hydroxy and oxo; or R44 and R45 together with the carbon atom to which they are attached form a cyclopropyl or cyclobutyl ring, wherein said ring are optionally substituted with hydroxy or halogen;

R70 and R71 are each independently selected from the group consisting hydrogen, halogen, C1-C6alkyl and C3-C10cycloalkyl, wherein said C1-C6alkyl and C3-C10cycloalkyl are optionally substituted with one or two substituents selected independently from the group consisting halogen, hydroxy and oxo; or R44 and R45 together with the carbon atom to which they are attached form a cyclopropyl or cyclobutyl ring, wherein said ring are optionally substituted with hydroxy or halogen;

R72 and R73 are each independently selected from the group consisting hydrogen, halogen, C1-C6alkyl and C3-C10cycloalkyl, wherein said C1-C6alkyl and C3-C10cycloalkyl are optionally substituted with one or two substituents selected independently from the group consisting halogen, hydroxy and oxo; or R44 and R45 together with the carbon atom to which they are attached form a cyclopropyl or cyclobutyl ring, wherein said ring are optionally substituted with hydroxy or halogen;

R30, R31, R42 and R43 are each independently selected from the group consisting of hydrogen, halogen, —CN, —C(═O)OH, —C(═O)R46, —CH(OH)—R47, trifluoromethyl, hydroxy, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44—R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48R49, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═CR51R52, —(CR44R45)m—C≡C—R53, —(CR44R45)m—C3-C10heterocyclyl substituted with R54, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, —(CR44R45)m-aryl substituted with R56 and R57 and —(CR44R45)m-heteroaryl substituted with R56 and R57;

R90 and R91 are each independently selected from the group consisting of hydrogen, halogen, ═O, —CN, —C(═O)OH, —C(═O)R46, —CH(OH)—R47, hydroxy, trifluoromethyl, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48R49, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═CR51R52, —(CR44R45)m—C≡C—R53, —(CR44R45)m—C3-C10heterocyclyl substituted with R54, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, —(CR44R45)m-aryl substituted with R56 and R57 and —(CR44R45)m-heteroaryl substituted with R56 and R57;

m is 0 or 1;

R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, C3-C10heterocyclyl, C3-C10cycloalkyl, aryl and heteroaryl, wherein said C1-C6alkyl, C3-C10heterocyclyl, C3-C10cycloalkyl, aryl and heteroaryl are optionally substituted with one, two or three independently selected R58;

R34, R35, and R36 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, C3-C10cycloalkyl and heteroaryl, wherein said C1-C6alkyl, C3-C10cycloalkyl and heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl and hydroxy; or R34 and R35 together with the nitrogen to which they are attached form a 4 to 6 membered ring, wherein said 4 to 6 membered ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy or halogen;

R26, R27, R46, R47, R49, R50, R51, R52 and R53 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, heteroaryl and C3-C10cycloalkyl, wherein said C1-C6alkyl, heteroaryl and C3-C10cycloalkyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, —OCH2CH2OH, carboxy and hydroxy;

R54, R55, R56 and R57 are each independently selected from the group consisting of hydrogen, halogen, —CN, trifluoromethyl, —OCH2CH2OH, hydroxyl, C1-C6alkyl, heteroaryl and C3-C10cycloalkyl, wherein said C1-C6alkyl, heteroaryl and C3-C10cycloalkyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, —OCH2CH2OH, carboxy and hydroxy;

R48 and R49 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, tetrahydropyrane, cyclohexyl and cyclopentyl, wherein said C1-C6alkyl, tetrahydropyrane, cyclohexyl and cyclopentyl are optionally substituted with one or two substituents independently selected from the group consisting of halogen and hydroxy; or R48 and R49 together with the nitrogen to which they are attached form a 4 to 6 membered ring, wherein said 4 to 6 membered ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and halogen;

R58 are each independently selected from the group consisting of halogen, —CN, hydroxy, oxo, —C(═O)OH, —S(═O)2R59, —S—NR60R61, S(═O)2NR60R61, cyclopropyl, C1-C6alkyl, —C(═O)NR60R61, —NR60C(═O)NR61R60, —NR60S(═O)2R59 and —NC(═O)R59;

R59 is selected from the group consisting of hydrogen, C1-C6alkyl, C3-C10cycloalkyl, aryl and heteroaryl, wherein said C1-C6alkyl, C3-C10cycloalkyl, aryl and heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, —CN and hydroxy;

R60 and R61 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, C3-C10heterocyclyl, C3-C10cycloalkyl and heteroaryl, wherein said C1-C6alkyl, C3-C10heterocyclyl, C3-C10cycloalkyl and heteroaryl are optionally substituted with one or two substituents independently selected from the group consisting of halogen and hydroxy; or R60 and R61 together with the nitrogen to which they are attached form a 4 to 6 membered ring, wherein said 4 to 6 membered ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and halogen;

R103 is selected from the group consisting of C3-C10heterocyclyl substituted with two substituents independently selected from the group consisting of R62 and R63, C3-C10cycloalkyl substituted with R30 and R31, aryl substituted with R30 and R31, heteroaryl substituted with two substituents independently selected from the group consisting of R62 and R63, —C(═O)R93, —CH(OH)—R33, —C(═O)—NR94R95, —NR36C(═O)R37, —OR38, —SR38, —S(═O)2R39, —S(═O)2NR34R35, —NR34S(═O)2—R40, —NR24R25—, —NR34C(═O)—NR34R35, —C═C substituted with R41 and R42, W and —C≡C substituted with R43;

W is selected from the group consisting of pyrrolidinone, tetrahydropyrane, 1,4-dioxane, aziridinone, azetidinone, piperidinone, thiazole, imidazole, tetrahydrofurane and oxepane;

R93 is selected from the group consisting of hydrogen, C3-C10heterocyclyl, C3-C10cycloalkyl, aryl and heteroaryl, wherein said C3-C10heterocyclyl, C3-C10cycloalkyl, aryl and heteroaryl are optionally substituted with one, two or three independently selected R58;

R94 and R95 are each independently selected from the group consisting of hydrogen, C3-C10cycloalkyl and heteroaryl, wherein said C3-C10cycloalkyl and heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl and hydroxy; or R94 and R95 together with the nitrogen to which they are attached form a 4 to 6 membered ring, wherein said 4 to 6 membered ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy or halogen;

R62 is selected from the group consisting of halogen, —C(═O)OH, —CH(OH)—R47, —C(═O)—NR48R49, —NR48C(═O)R46, —SR49, —S(═O)2R50, —S(═O)2NR48R49, —NR48S(═O)2R50, —NR48C(═O)—NR48R49, —C═C—R51R52, —C≡C—R53, CH2CH2OH, —CH2CH2OH, C3-C10heterocyclyl substituted with R54, C3-C10cycloalkyl substituted with R55, aryl substituted with R56 and R57 and heteroaryl substituted with R56 and R57;

R63 is selected from the group consisting of hydrogen, ═O, halogen, hydroxy, trifluoromethyl, —CN, oxo, —C(═O)OH, —S(═O)2R59, —S(═O)2NR60R61, —S(═O)NR60R61 cyclopropyl, —OR59, —SR59, —C1-C6alkyl, —C(═O)NR60R61, —NR60C(═O)NR61R60; —NR60S(═O)2R59, and —N(C═O)R59;

a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, including a racemic mixture, or any tautomeric forms.

2. The compound according to clause 1, wherein Y is —X1—X2—X3—R3.
3. The compound according to clause 2, wherein X1 is selected from the group consisting of —S— and —S(═O)2—.
4. The compound according to clause 3, wherein X1 is —S(═O)2—.
5. The compound according to any one of clauses 2-4, wherein X2 is absent or is selected from the group consisting of —CR44R45— and —NR25—.
6. The compound according to clause 5, wherein X2 is absent or is —CR44R45.
7. The compound according to any one of clauses 2-6, wherein X3 is absent or is —CR70R71—.
8. The compound according to any one of clauses 2-7, wherein —X1—X2—X3—R3 is selected from the group consisting of —S—R3, —S(═O)2—R3, —S(═O)2—NR25R3, —S(═O)2—CR44R45—R3.
9. The compound according to clause 8, wherein —X1—X2—X3—R3 is selected from the group consisting of —S—R3, —S(═O)2—R3.
10. The compound according to clause 8, wherein —X1—X2—X3—R3 is selected from the group consisting of —S(═O)2—NR25R3, —S(═O)2—CR44R45—R3.
11. The compound according to clause 1, wherein Y is selected from the group consisting of —CR72R73—O—CR70R71—R3, —CR72R73—S—CR70R71—R3, —CR72R73—S(═O)2—CR70R71—R3, —CR72R73—NR25—S(═O)2—R3, —CR72R73—CR70R71—S(═O)2—R3, —CR72R73—CR70R71—O—R3, —CR72R73—CR70R71—S—R3, —CR72R73—CR70R71—NR25—R3, —O—CR44R45—S(═O)2—R3, —CR72R73—O—R3, —CR72R73—S—R3, —CR72R73—S(═O)2—R3, —CR72R73—NR25—R3, —CR72R73—S(═O)2—R3, —O—R103—CR72R73—CR44R45—R103, —O—CR44R45—CR70R71—R103, —CR72R73—CR44R45—CR70R71—R103, and —CR72R73—R103.
12. The compound according to clause 11, wherein Y is selected from the group consisting of —CR72R73—O—CR70R71—R3, —CR72R73—S—CR70R71—R3, —CR72R73—S(═O)2—CR70R71—R3, —CR72R73—NR25—S(═O)2—R3, —CR72R73—CR70R71—S(═O)2—R3, —CR72R73—CR70R71—O—R3 and —CR72R73—CR70R71—NR25—R3.
13. The compound according to clause 12, wherein Y is selected from the group consisting of —CR72R73—O—CR70R71—R3, —CR72R73—S—CR70R71—R3, —CR72R73—CR70R71—O—R3 and —CR72R73—CR70R71—NR25—R3.
14. The compound according to clause 11, wherein Y is selected from the group consisting of —CR72R73—S(═O)2—CR70R71—R3, —CR72R73—CR70R71—S(═O)2—R3 and —CR72R73—NR25—S(═O)2—R3.
15. The compound according to clause 11, wherein Y is selected from the group consisting of —CR72R73—O—CR70R71—R3, —CR72R73—CR70R71—O—R3 and —CR72R73—CR70R71—NR25—R3.
16. The compound according to clause 1, wherein Y is selected from the group consisting of C3-C10cycloalkyl substituted with R19 and phenyl substituted with R22.
17. The compound according to clause 16, wherein Y is C3-C10cycloalkyl substituted with R19,
18. The compound according to clause 16, wherein Y is phenyl substituted with R22.
19. The compound according to any one of clauses 1-15, wherein R3 is selected from the group consisting of C3-C10heterocyclyl substituted with R30 and R31, C3-C10cycloalkyl substituted with R90 and R91, aryl substituted with R30 and R31, heteroaryl substituted with R90 and R91.
20. The compound according to any one of clauses 1-15, wherein R3 is selected from the group consisting of —C(═O)R32, —CH(OH)—R33, —(CR44R45)n—C(═O)—NR34R35, —(CR44R45)n—NR36C(═O)R37, —(CR44R45), —OR38, —(CR44R45)n—SR38, —(CR44R45)n—S(═O)2R39, —(CR44R45)n—S(═O)2NR34R35, —(CR44R45), —NR34S(═O)2—R40, —(CR44R45), —NR34R35, —(CR44R45)n—NR34C(═O)—NR34R35, —(CR44R45), —C═C—R41R42 and —(CR44R45), —C≡C—R43.
21. The compound according to any one of clauses 1-15, wherein R3 is selected from the group consisting of C3-C10heterocyclyl substituted with R30, C3-C10cycloalkyl substituted with R90, aryl substituted with R30, heteroaryl substituted with R90, —(CR44R45), —C(═O)—NR34R35, —(CR44R45), —NR36C(═O)R37, —(CR44R45), —OR38, —(CR44R45)n—S(═O)2R39, —(CR44R45)n—S(═O)2NR34R35, —(CR44R45)n—NR34S(═O)2—R40, —(CR44R45)n—NR34C(═O)—NR34R35, —(CR44R45)n—C═CR41R42 and —(CR44R45)n—C≡C—R43.
22. The compound according to any one of clauses 1-15, wherein R3 is selected from the group consisting of C3-C10heterocyclyl substituted with R30, C3-C10cycloalkyl substituted with R90, aryl substituted with R30; heteroaryl substituted with R90, —C(═O)—NR34R35, —NR36C(═O)R37, —OR38, —S(═O)2R39, —S(═O)2NR34R35, —NR34S(═O)2—R40, —NR34C(═O)—NR34R35, —C═CR41R42 and —C≡C—R43.
23. The compound according to any one of clauses 1-15, wherein R3 is selected from the group consisting of C3-C10heterocyclyl substituted with R30, C3-C10cycloalkyl substituted with R90, heteroaryl substituted with R30, —C(═O)—NR34R35, —NR36C(═O)R37, —OR38, —S(═O)2R39, —S(═O)2NR34R35, —NR34S(═O)2—R40, —NR34C(═O)—NR34R35, —C═CR41R42 and —C≡C—R43.

24. The compound according to any one of clauses 1-15, wherein R3 is selected from the group consisting of piperidine substituted with R30, pyrrolidine substituted with R30, morpholine substituted with R30, tetrahydropyranyl substituted with R30, cyclohexyl substituted with R30, cyclopropyl substituted with R30, cyclobutyl substituted with R30, cyclopentyl substituted with R30, phenyl substituted with R30; pyridazinyl substituted with R30, pyrazinyl substituted with R30, pyridine substituted with R30, imidazolyl substituted with R30, pyrazolyl substituted with R30 and pyrimidinyl substituted with R30, isoxazolyl substituted with R30, pyridinyl substituted with R30, —C(═O)—NR34R35, —NR36C(═O)R37, —OR38, —S(═O)2R39, —S(═O)2NR34R35, —NR34S(═O)2—R40, —NR34C(═O)—NR34R35 and —C≡C—R43.

25. The compound according to any one clauses 1-15, wherein R3 is selected from the group consisting of piperidine substituted with R30, pyrrolidine substituted with R30, morpholine substituted with R30, tetrahydropyranyl substituted with R30, cyclohexyl substituted with R30, cyclopropyl substituted with R30, cyclobutyl substituted with R30, cyclopentyl substituted with R30, phenyl substituted with R30; pyridazinyl substituted with R30, pyrazinyl substituted with R30, pyridine substituted with R30, imidazolyl substituted with R30, pyrazolyl substituted with R30 and pyrimidinyl substituted with R30, isoxazolyl substituted with R30, pyridinyl substituted with R30.
26. The compound according to any one of clauses 1-15, wherein R3 is selected from the group consisting of —NR36C(═O)R37, —NR34S(═O)2—R40 and —NR34C(═O)—NR34R35.
27. The compound according to any one of clauses 1-15, wherein R3 is selected from the group consisting of —C(═O)—NR34R35, —OR38, —S(═O)2R39, —S(═O)2NR34R35 and —C≡C—R43.
28. The compound according to any one of clauses 1-15, wherein n is selected from the group consisting of 0 or 1.
29. The compound according to clause 28, wherein n is 0.
30. The compound according to clause 11, wherein R103 is selected from the group consisting of —C(═O)R93, —CH(OH)—R33, —C(═O)—NR94R95, —NR36C(═O)R37, —OR38, —SR38, —S(═O)2R39, —S(═O)2NR34R35, —NR34S(═O)2—R40, —NR24R25—, —NR34C(═O)—NR34R35, —C═C substituted with R41 and R42, W and substituted with R43.
31. The compound according to clause 11, wherein R103 is selected from the group consisting of C3-C10heterocyclyl substituted with two substitutions independently selected from the group consisting of R62 and R63, C3-C10cycloalkyl substituted with R30 and R31, aryl substituted with R30 and R31, heteroaryl substituted with two substitutions independently selected from the group consisting of R62 and R63.
32. The compound according to clause 11, wherein R103 is selected from the group consisting of C3-C10heterocyclyl substituted with two substitutions independently selected from the group consisting of R62 and R63 and heteroaryl substituted with two substitutions independently selected from the group consisting of R62 and R63.
33. The compound according to clause 11, wherein R103 is selected from the group consisting of cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl substituted with R30 and R31 and phenyl substituted with R30 and R31, tetrahydropyranyl, piperidinyl, pyrrolidinyl and morpholinyl substituted with two substitutions independently selected from the group consisting of R62 and R63 and imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with two substitutions independently selected from the group consisting of R62 and R63.
34. The compound according to clause 11, wherein R103 is selected from the group consisting of tetrahydropyranyl, piperidinyl, pyrrolidinyl and morpholinyl substituted with two substitutions independently selected from the group consisting of R62 and R63 and imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with one or two substitutions independently selected from the group consisting of R62 and R63.
35. The compound according to any one of clauses 31-34, wherein R103 comprises at least one R62 group.
36. The compound according to clause 11, wherein R103 is selected from the group consisting of C3-C10cycloalkyl substituted with R30 and R31 and aryl substituted with R30 and R31;
37. The compound according to clause 11, wherein R103 is selected from the group consisting of cyclopropyl, cyclobutyl, cyclohexyl, phenyl and cyclopentyl substituted with R30 and R31;
38. The compound according to clause 11, wherein R103 is selected from the group consisting of —C(═O)—NR94R95, —NR36C(═O)R37, —OR38, —SR38, —S(═O)2R39, —S(═O)2NR34R35, —NR34S(═O)2—R40, —NR34C(═O)—NR34R35, W and —C≡C substituted with R43.
39. The compound according to clause 11, wherein R103 is selected from the group consisting of —C(═O)—NR94R95, —NR36C(═O)R37, —OR38, S(═O)R39—S(═O)2NR34R35, —NR34S(═O)2—R40, —NR34C(═O)—NR34R35 and W.
40. The compound according to clause 11, wherein R103 is selected from the group consisting of —NR36C(═O)R37, —NR34S(═O)2—R40 and —NR34C(═O)—NR34R35.
41. The compound according to clause 11, wherein R103 is selected from the group consisting of —C(═O)—NR94R95, —OR38, —S(═O)2R39, —S(═O)2NR34R35 and W.
42. The compound according to clause 11, wherein R103 is W selected from the group consisting of pyrrolidinone, tetrahydropyrane, 1,4-dioxane, piperidinone, thiazole, imidazole and tetrahydrofurane.
43. The compound according to clause 11, wherein R103 is W selected from the group consisting of pyrrolidinone, tetrahydropyrane, piperidinone and imidazole.
44. The compound according to any one clauses 1-43, wherein R1 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl and cyclopropyl and R2 is selected from the group consisting of a monovalent radical having one of the following formulae, wherein the symbol * denotes the point of attachment:












































45. The compound according to clause 44, wherein R1 is selected from the group consisting of hydrogen and methyl.
46. The compound according to clause 44, wherein R1 is hydrogen.
47. The compound according to clause 44, wherein R1 is methyl.
48. The compound according to any one of clauses 44-47, wherein R2 is selected from the group consisting of:
































49. The compound according to clause 48, wherein R2 is selected from the group consisting of:




















50. The compound according to clause 48, wherein R2 is




51. The compound according to clause 48, wherein R2 is












52. The compound according to clause 48, wherein R2 is




53. The compound according to clause 48, wherein R2 is




54. The compound according to clause 48, wherein R2 is




55. The compound according to clause 48, wherein R2 is




56. The compound according to any one of clauses 1-43, wherein R1 and R2 together with the nitrogen to which they are attached is selected from the group consisting of:




























57. The compound according to clause 56, wherein R1 and R2 together with the nitrogen to which they are attached is




58. The compound according to any one any one of clauses 44-51 and 53-57, wherein Q is a hydroxyl group.
59. The compound according to any one of any one of clauses 44-51 and 53-57, wherein Q is a carboxy gorup.
60. The compound according to any one of clauses 44-51 and 53-57, wherein Q is a —S(═O)2R6 group.
61. The compound according to any one of clauses 44-51 and 53-57, wherein Q is selected is a —S(═O)2NH2 group.
62. The compound according to any one of clauses 44-52 wherein P is a —S(═O)2R6 group.
63. The compound according to any one of clauses 44-52, wherein P is a carboxy group.
64. The compound according to any one of clauses 44-52, wherein P is a —S(═O)2NH2 group.
65. The compound according to clause 60 or 62, wherein R6 is selected from the group consisting of methyl, isopropyl, ethyl, phenyl, pyridine, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said methyl, isopropyl, ethyl, phenyl, pyridine, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one or two independently selected R7.
66. The compound according to clause 60 or 62, wherein R6 is selected from the group consisting of methyl, ethyl, isopropyl, phenyl, pyridine, cyclopropyl and cyclohexyl, wherein said methyl, isopropyl, phenyl, pyridine, cyclopropyl and cyclohexyl are optionally substituted with R7.
67. The compound according to clauses 65 or 66, wherein R7 is selected from the group consisting of hydrogen, methyl, cyclopropyl, —O—CH3, —O-cyclopropyl, —O-isopropyl, hydroxy, fluoride and chloride, wherein said methyl, ethyl, cyclopropyl, —O—CH3, —O-isopropyl and —O-cyclopropyl is optionally substituted with one substituent selected from the group consisting of hydroxy and halogen.
68. The compound according to clause 65 or 66, wherein R7 is selected from the group consisting of hydrogen, methyl, cyclopropyl, —O-cyclopropyl, —O-isopropyl, hydroxy, fluoride and chloride, wherein said ethyl, cyclopropyl and —O-cyclopropyl is optionally substituted with one substituent selected from the group consisting of hydroxy and halogen.
69. The compound according to any one clauses 1-68, wherein R4 is selected from the group consisting of hydrogen, methyl, isopropyl, ethyl, —O-methyl, —O-isopropyl, —O-ethyl, wherein said, methyl, isopropyl, ethyl, —O-methyl, —O-isopropyl, —O-ethyl are substituted with R12 and R13, trifluoromethyl, CN, fluorine, chlorine, —S(═O)2methyl, —S(═O)2ethyl, —S(═O)2cyclopropyl, —S(═O)2NHR11 and —C(═O)NHR10.
70. The compound according to any one clauses 1-68, wherein R4 is selected from the group consisting of hydrogen, methyl, isopropyl, ethyl, —O-methyl, —O-isopropyl, —O-ethyl, wherein said, methyl, isopropyl, ethyl, —O-methyl, —O-isopropyl, —O-ethyl are, substituted with R12, trifluoromethyl, fluorine, chlorine, —S(═O)2(methyl)2, —S(═O)2methyl, —S(═O)2ethyl, —S(═O)2cyclopropyl, —S(═O)2Nmethyl, —S(═O)2Nisopropyl, —C(═O)Nisopropyl, —C(═O)N(methyl)2 and —C(═O)Nmethyl.
71. The compound according to any one clause 1-68, wherein R4 is selected from the group consisting of hydrogen, methyl, isopropyl, —O-methyl, —O-isopropyl, —O-ethyl, trifluoromethyl, fluorine, chlorine, —S(═O)2methyl, —S(═O)2ethyl, —S(═O)2cyclopropyl, —S(═O)2Nmethyl, —S(═O)2Nisopropyl, —C(═O)Nisopropyl and —C(═O)Nmethyl.
72. The compound according to any one of clauses 69-71 wherein R4 is in the ortho position.
73. The compound according to any one of clauses 69-71, wherein R4 is in the meta position.
74. The compound according to any one of clauses 44-48 and 69-73, wherein R95 is selected from the group consisting of methyl, isopropyl, ethyl, phenyl, pyridine, pyrimidine, cyclopropyl, cyclobutyl and cyclohexyl, wherein said ethyl, phenyl, pyridine, pyrimidine, cyclopropyl, cyclobutyl and cyclohexyl are optionally substituted with one or two independently selected R96.
75. The compound according to any one of clauses 44-48 and 69-73 wherein R95 is selected from the group consisting of methyl, isopropyl, phenyl, pyridine, pyrimidine, cyclopropyl and cyclohexyl, wherein said ethyl, phenyl, pyridine, pyrimidine, cyclopropyl and cyclohexyl are optionally substituted with one R96.
76. The compound according to clauses 74 or 75, wherein R96 is selected from the group consisting of fluorine, chlorine, hydroxy, oxo, trifluoromethyl, methyl, isopropyl, ethyl and —S(═O)2methyl.
77. The compound according clauses 74 or 75, wherein R96 is selected from the group consisting of fluorine, chlorine, hydroxy, trifluoromethyl, methyl, isopropyl and —S(═O)2methyl.
78. The compound according to any one of clauses 44-48 and 69-73, wherein R97 is selected from the group consisting of hydrogen, methyl, isopropyl and ethyl.
79. The compound according to any one of clauses 44-48 and 69-73, wherein R97 is selected from the group consisting of hydrogen, methyl and isopropyl.
80. The compound according to any one of clauses 1-79, wherein R12 is selected from the group consisting of hydrogen, —O-(methyl, isopropyl, ethyl), fluorine, chlorine, carboxy and hydroxy.
81. The compound according to any one of clauses 1-79, wherein R12 is selected from the group consisting of hydrogen, —O-methyl, —O-isopropyl, fluorine and hydroxy.
82. The compound according to any one of clauses 1-81, wherein R13 is selected from the group consisting of hydrogen, —O-(methyl, isopropyl, ethyl), fluorine, chlorine, carboxy and hydroxy.
83. The compound according to any one of clauses 1-79, wherein R13 is selected from the group consisting of hydrogen, —O-methyl, —O-isopropyl, fluorine and hydroxy.
84. The compound according to any one of clauses 1-83, wherein R5 is selected from the group consisting of hydrogen, methyl, isopropyl, ethyl, trifluoromethyl, CN, fluorine, chlorine, acetyl, ethy, carbonyl, —S(═O)2R17, S(═O)2NR14R15, S-methyl, S-isopropyl, and S-ethyl; wherein said methyl, isopropyl, ethyl are substituted with R16 and; wherein said ethyl and carbonyl are substituted with R18.
85. The compound according to any one of clauses 1-83, wherein R5 is selected from the group consisting of hydrogen, methyl, isopropyl, ethyl, trifluoromethyl, fluorine, chlorine, acetyl, —S(═O)2methyl, —S(═O)2 isopropyl, S(═O)2NH2, S(═O)2N(CH3)2, S-methyl, S-isopropyl, and S-ethyl; wherein said methyl, isopropyl, and ethyl are optionally substituted with fluorine or hydroxyl.
86. The compound according to any one clauses 1-83, wherein R5 is selected from the group consisting of hydrogen, methyl, isopropyl, trifluoromethyl, fluorine, chlorine, acetyl, —S(═O)2methyl and —S(═O)2 isopropyl.
87. The compound according to any one of clauses 1-86, wherein R10 and R11 are each independently selected from the group consisting of hydrogen, and C1-C4alkyl.
88. The compound according to any one of clauses 1-86, wherein R10 and R11 are each independently selected from the group consisting of hydrogen, methyl, ethyl and isopropyl.
89. The compound according to any one clauses 1-86, wherein R10 and R11 together with the nitrogen to which they are attached form a piperidinyl, pyrrolidinyl and morpholinyl ring, wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and fluoride.
90. The compound according to any one clauses 1-86, wherein R10 and R11 together with the nitrogen to which they are attached form a piperidinyl, ring, wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and fluoride.
91. The compound according to any one of clauses 1-90, wherein R14 and R15 are each independently selected from the group consisting of hydrogen, and C1-C4alkyl.
92. The compound according to any one of clauses 1-90, wherein R14 and R15 are each independently selected from the group consisting of hydrogen, methyl, ethyl and isopropyl.
93. The compound according to any one of clauses 1-90, wherein R14 and R15 together with the nitrogen to which they are attached form a piperidinyl, pyrrolidinyl and morpholinyl ring wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and fluoride.
94. The compound according to any one of clauses 1-90, wherein R14 and R15 together with the nitrogen to which they are attached form a piperidinyl ring, wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and fluoride
95. The compound according to any one of clauses 1-94, wherein R16 is selected from the group consisting of hydrogen —O-methyl, methyl, cyclopropyl, fluorine, chlorine, —S(═O)2-methyl, —S(═O)2-ethyl, —C(═O)NH2, —C(═O)N—CH3CH3, carboxy, and hydroxy.
96. The compound according to any one of clauses 1-94, wherein R16 is selected from the group consisting of hydrogen, methyl, cyclopropyl, fluorine, —S(═O)2-methyl, —C(═O)N—(CH3)2 and hydroxy.
97. The compound according to any one of clauses 1-96, wherein R18 is selected from the group consisting of hydrogen —O-methyl, methyl, cyclopropyl, fluorine, chlorine, —S(═O)2-methyl, —S(═O)2-ethyl, —C(═O)NH2, —C(═O)N—CH3CH3, carboxy, and hydroxy.
98. The compound according to any one of clauses 1-96, wherein R18 is selected from the group consisting of hydrogen, methyl, cyclopropyl, fluoride, —S(═O)2-methyl, —C(═O)N—(CH3)2 and hydroxy.
99. The compound according to any one clauses 1-98, wherein R17 is selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, wherein said ethyl and isopropyl is optionally substituted with one or two substituents selected from the group consisting of hydroxyl, fluorine and chlorine.
100. The compound according to any one of clauses 1-98, wherein R17 is selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, wherein said ethyl is optionally substituted with one substituents selected from the group consisting of hydroxy and fluorine.
101. The compound according to any one of clauses 1-100, wherein R19 is selected from the group consisting of halogen, —CN, —C(═O)R46, —CH(OH)—R47, —(CR44R45)m—C(═O)—NR48R49, (CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═C—R51R52, and —(CR44R45)m—C≡C—R53.
102. The compound according to any one of clauses 1-100, wherein R19 is selected from the group consisting of, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, and —(CR44R45)m-aryl substituted with R56 and R57.
103. The compound according to any one of clauses 1-100, wherein R19 is selected from the group consisting of —CN, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—OR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48C(═O)—NR48R49.
104. The compound according to any one of clauses 1-100, wherein R19 is selected from the group consisting of, —C3-C10cycloalkyl substituted with R55, and -phenyl substituted with R56.
105. The compound according to any one of clauses 1-100, wherein R19 is selected from the group consisting of —CN, —C(═O)—NR48R40, —NR48C(═O)R46, —OR49, —S(═O)R50—, S(═O)2NR49R49, —NR48S(═O)2R50, —NR48C(═O)—NR48R49.
106. The compound according to any one of clauses 1-105, wherein R22 is selected from the group consisting of halogen, —CN, hydroxy, —C(═O)OH, —C(═O)R46, —CH(OH)—R47, hydroxy, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44—R45)m—NR48R49, —CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═C—R51R52, —(CR44R45)m—C≡C—R53.
107. The compound according to any one of clauses 1-105 wherein R22 is selected from the group consisting of —(CR44R45)m—C3-C10heterocyclyl substituted with R54, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, —(CR44R45)m-aryl substituted with R56 and R57 and —(CR44R45)m-heteroaryl substituted with R56 and R57.
108. The compound according to any one of clauses 1-105, wherein R22 is selected from the group consisting of fluorine, chlorine, —CN, hydroxy, —C(═O)OH, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)mNR48S(═O)2R50, —(CR44R45)m—NR48R49 
109. The compound according to any one of clauses 1-105 wherein R22 is selected from the group consisting of —C3-C10heterocyclyl substituted with R54, —C3-C10cycloalkyl substituted with R55, -phenyl substituted with R56 and -heteroaryl substituted with R56.
110. The compound according to any one clauses 1-105, wherein R22 is selected from the group consisting of fluorine, chlorine, —CN, hydroxy, —C(═O)OH, —C(═O)—NR48R49, —NR48C(═O)R46, —OR49, —S(═O)2R50, —S(═O)2NR48R49, —NR48S(═O)2R50, —NR48C(═O)—NR48R49.
111. The compound according to any one of clauses 1-105, wherein R22 is selected from the group consisting of tetrahydropyranyl, piperidinyl, pyrrolidinyl and morpholinyl substituted with R54, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl substituted with R55, -phenyl substituted with R56 and imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R56.
112. The compound according to any one of clauses 1-105, wherein R22 is selected from the group consisting of tetrahydropyranyl, piperidinyl and morpholinyl substituted with R54, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl substituted with R55, phenyl substituted with R56 and pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R56.
113. The compound according to any one of clauses 1-105, wherein R22 is selected from the group consisting of C═C—R51R52, —C≡C—R53 and —CH2CH2OH.
114. The compound according to any one of clauses 1-113, wherein R24 is selected from the group consisting of —C(═O)—R26, —S(═O)2—R27, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R28, and phenyl substituted with R29.
115. The compound according to any one of clauses 1-113, wherein R24 is selected from the group consisting of —C(═O)—R26, —S(═O)2—R27, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R28, and phenyl substituted with R29.
116. The compound according to any one of clauses 1-115, wherein R25 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl and cyclopropyl.
117. The compound according to any one of clauses 1-115, wherein R25 is selected from the group consisting of hydrogen, methyl, isopropyl and cyclopropyl.
118. The compound according to any one of clauses 1-117, wherein R125 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl and cyclopropyl.
119. The compound according to any one of clauses 1-118, wherein R125 is selected from the group consisting of hydrogen, methyl, isopropyl and cyclopropyl.
120. The compound according to any one of clauses 1-119, wherein R44 and R45 are each independently selected from the group consisting hydrogen, fluorine, chlorine, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one substituent selected independently from the group consisting of fluorine, chlorine, hydroxy and oxo.
121. The compound according to any one of clauses 1-119, wherein R44 and R45 are each independently selected from the group consisting hydrogen, fluorine, chlorine, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said ethyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one substituent selected independently from the group consisting of fluorine and hydroxyl.
122. The compound according to any one of clauses 1-121, wherein R44 and R45 together with the carbon atom to which they are attached form a cyclopropyl ring, wherein said ring are optionally substituted with hydroxy or fluorine.
123. The compound according to any one of clauses 1-122, wherein R44 and R45 together with the carbon atom to which they are attached form a cyclobutyl ring, wherein said ring are optionally substituted with hydroxy or fluorine.
124. The compound according to any one of clauses 1-123, wherein R70 and R71 are each independently selected from the group consisting hydrogen, fluorine, chlorine, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one substituent selected independently from the group consisting of fluorine, chlorine, hydroxy and oxo.
125. The compound according to any one of clauses 1-123, wherein R70 and R71 are each independently selected from the group consisting hydrogen, fluorine, chlorine, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said ethyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one substituent selected independently from the group consisting of fluorine and hydroxyl.
126. The compound according to any one of clauses 1-123, wherein R70 and R71 together with the carbon atom to which they are attached form a cyclopropyl ring, wherein said ring are optionally substituted with hydroxy or fluorine.
127. The compound according to any one of clauses 1-123, wherein R70 and R71 together with the carbon atom to which they are attached form a cyclobutyl ring, wherein said ring are optionally substituted with hydroxy or fluorine.
128. The compound according to any one of clauses 1-123, wherein R72 and R73 are each independently selected from the group consisting hydrogen, fluorine, chlorine, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one substituent selected independently from the group consisting of fluorine, chlorine, hydroxy and oxo.
129. The compound according to any one of clauses 1-123, wherein R72 and R73 are each independently selected from the group consisting hydrogen, fluorine, chlorine, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said ethyl, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one substituent selected independently from the group consisting of fluorine and hydroxyl.
130. The compound according to any one of clauses 1-123, wherein R72 and R73 together with the carbon atom to which they are attached form a cyclopropyl ring, wherein said ring are optionally substituted with hydroxy or fluorine.
131. The compound according to any one clauses 1-123, wherein R72 and R73 together with the carbon atom to which they are attached form a cyclobutyl ring, wherein said ring are optionally substituted with hydroxy or fluorine.
132. The compound according to any one of clauses 1-131, wherein R30 and R31 are each independently selected from the group consisting of hydrogen, halogen, CN, —C(═O)OH, —C(═O)R46, —CH(OH)—R47, hydroxy, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48R49, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44—R45)m—C═C—R51R52, and —(CR44R45)m—C≡C—R53.
133. The compound according to any one of clauses 1-131, wherein R30 and R31 are each independently selected from the group consisting of hydrogen, halogen, CN, —C(═O)OH, hydroxy, —(CR44R45)m—C(O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48C(═O)—NR48R49, and —(CR44R45)m—C≡C—R53.
134. The compound according to any one of clauses 1-131, wherein R30 and R31 are each independently selected from the group consisting of hydrogen, halogen, CN, —C(═O)OH, hydroxy, —C(═O)—NR48R49, —NR48C(═O)R46, —OR49, —S(═O)2R50, —S(═O)2NR48R49, —NR48S(═O)2R50, —NR48C(═O)—NR48R49 and —C≡C—R53.
135. The compound according to any one clauses 1-131, wherein R30 and R31 are each independently selected from the group consisting of hydrogen, halogen, CN, —C(═O)OH, hydroxy, —C(═O)—NR48R49, —S(═O)2R50 and —S(═O)2NR48R49.
136. The compound according to any one of clauses 1-131, wherein R30 and R31 are each independently selected from the group consisting of hydrogen, halogen, CN, —C(═O)OH, hydroxy, —NR48C(═O)R46, —OR49, —NR48S(═O)2R50 and —NR48C(═O)—NR48R49.
137. The compound according to any one of clauses 1-131, wherein R30 and R31 are each independently selected from the group consisting of hydrogen, chlorine, fluorine, CN, —C(═O)OH, hydroxy, —NHC(═O)C1-4alkyl, —OC1-4alkyl, —OCH2CH2OH, —NHS(═O)2C1-4alkyl and —NHC(═O)—N(C1-4alkyl)2.
138. The compound according to any one of clauses 1-137, wherein R30, R31, R42 and R43 are each independently selected from the group consisting of —(CR44R45)m—C3-C10heterocyclyl substituted with R54, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, —(CR44R45)m-aryl substituted with R56 and R57 and —(CR44R45)m-heteroaryl substituted with R56 and R57.
139. The compound according to any one of clauses 1-137, wherein R30, R31, R42 and R43 are each independently selected from the group consisting of —C3-C10heterocyclyl substituted with R54, —C3-C10cycloalkyl substituted with R55, -phenyl substituted with R56 and R57 and -heteroaryl substituted with R56 and R57.
140. The compound according to any one of clauses 1-137, wherein R30, R31, R42 and R43 are each independently selected from the group consisting of tetrahydropyranyl, piperidinyl, pyrrolidinyl and morpholinyl substituted with R54, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl substituted with R55, phenyl substituted with R56 and R57 and imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R56 and R57.
141. The compound according to any one of clauses 1-137, wherein R30, R31, R42 and R43 are each independently selected from the group consisting of tetrahydropyranyl, piperidinyl, pyrrolidinyl and morpholinyl substituted with R54, cyclopropyl, cyclobutyl and cyclohexyl substituted with R55, phenyl substituted with R56 and R57 and pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R56 and R57.
142. The compound according to any one of clauses 1-141, wherein R90 and R91 are each independently selected from the group consisting of hydrogen, halogen, ═O, —CN, —C(═O)OH, —C(═O)R46, —CH(OH)—R47, hydroxy, trifluoromethyl, —(CR44R45)m—C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)m—OR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R59, —(CR44R45)m—NR48R49, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═CR51R52, and —(CR44R45)m—C≡C—R53.
143. The compound according to any one of clauses 1-141, wherein R90 and R91 are each independently selected from the group consisting of hydrogen, fluorine, chlorine, ═O, —CN, —C(═O)—NR48R49, —(CR44R45)m—NR48C(═O)R46, —(CR44R45)mOR49, —(CR44R45)m—SR49, —(CR44R45)m—S(═O)2R50, —(CR44R45)m—S(═O)2NR48R49, —(CR44R45)m—NR48S(═O)2R50, —(CR44R45)m—NR48C(═O)—NR48R49, —(CR44R45)m—C═CR51R52, and —(CR44R45)m—C≡C—R53.
144. The compound according to any one of clauses 1-141, wherein R90 and R91 are each independently selected from the group consisting of hydrogen, fluorine, chlorine, —CN, —C(═O)OH, —NR48C(═O)R46, —NR48S(═O)2R50 and —NR48C(═O)—NR48R49.
145. The compound according to any one of clauses 1-141, wherein R90 and R91 are each independently selected from the group consisting of hydrogen, fluorine, chlorine, ═O, —CN, —C(═O)OH, —C(═O)—NR48R49, —OR49, —SR49, —S(═O)2R50, —S(═O)2NR48R49, —C═CR51R52 and —C≡C—R53.
146. The compound according to any one of clauses 1-141, wherein R90 and R91 are each independently selected from the group consisting of hydrogen, —(CR44R45)m—C3-C10heterocyclyl substituted with R54, —(CR44R45)m—C3-C10cycloalkyl substituted with R55, —(CR44R45)m-aryl substituted with R56 and R57 and —(CR44R45)m-heteroaryl substituted with R56 and R57.
147. The compound according to any one of clauses 1-141, wherein R90 and R91 are each independently selected from the group consisting of hydrogen, tetrahydropyranyl, piperidinyl, pyrrolidinyl and morpholinyl substituted with R54, cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl substituted with R55, phenyl substituted with R56 and R57 and -imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R56 and R57.
148. The compound according to any one of clauses 1-141, wherein R90 and R91 are each independently selected from the group consisting of hydrogen, tetrahydropyranyl, piperidinyl and morpholinyl substituted with R54, cyclopropyl, cyclobutyl and cyclohexyl substituted with R55, phenyl substituted with R56 and R57 and pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl substituted with R56 and R57.
149. The compound according to any one of clauses 1-148, wherein m is 0.
150. The compound according to any one of clauses 1-148, wherein m is 1.
151. The compound according to any one of clauses 1-150, wherein R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, C1-C6alkyl and C3-C10cycloalkyl, wherein said C1-C6alkyl and C3-C10cycloalkyl are optionally substituted with one or two independently selected R58.
152. The compound according to clause 150, wherein R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, C1-C6alkyl and C3-C10cycloalkyl, wherein said C1-C6alkyl and C3-C10cycloalkyl are optionally substituted with one R58.
153. The compound according to clause 150, wherein R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, trifluoromethyl and cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl, wherein said methyl, ethyl and isopropyl, trifluoromethyl and cyclopropyl, cyclobutyl, cyclohexyl and cyclopentyl are optionally substituted with one R58.
154. The compound according to clause 150, wherein R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, C3-C10heterocyclyl, aryl and heteroaryl, wherein said C3-C10heterocyclyl, aryl and heteroaryl are optionally substituted with one or two independently selected R58.
155. The compound according to clause 150, wherein R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, C3-C10heterocyclyl, aryl and heteroaryl, wherein said C3-C10heterocyclyl, aryl and heteroaryl are optionally substituted with one or two independently selected R58.
156. The compound according to clause 150, wherein R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, phenyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl wherein said tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, phenyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl pyrimidinyl and pyridinyl are optionally substituted with one or two independently selected R58.
157. The compound according to clause 150, wherein R32, R33, R37, R38, R39, R40 and R41 are each independently selected from the group consisting of hydrogen, tetrahydropyranyl, piperidinyl, morpholinyl, phenyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl wherein said tetrahydropyranyl, piperidinyl, morpholinyl, phenyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one R58.
158. The compound according to any one of clauses 1-157, wherein R34, R35, and R36 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, C3-C10cycloalkyl and heteroaryl, wherein said C1-C6alkyl, C3-C10cycloalkyl and heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl and hydroxyl.
159. The compound according to any one clauses 1-158, wherein R34 and R35 together with the nitrogen to which they are attached form a piperidinyl, pyrrolidinyl and morpholinyl ring, wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy or fluorine.
160. The compound according to any one of clauses 1-157, wherein R34, R35, and R36 are each independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three substituents independently selected from the group consisting of fluorine, methyl, ethyl and hydroxyl.
161. The compound according to any one of clauses 1-157, wherein R34, R35, and R36 are each independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one substituent independently selected from the group consisting of fluorine, methyl, ethyl and hydroxyl.
162. The compound according to any one of clauses 1-161, wherein R26, R27, R46, R47, R49, R50, R51, R53 and R52 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, heteroaryl and C3-C10cycloalkyl, wherein said C1-C6alkyl, heteroaryl and C3-C10cycloalkyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, —OCH2CH2OH, carboxy and hydroxy.
163. The compound according to any one of clauses 1-162, wherein R54, R55, R56 and R57 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, heteroaryl and C3-C10cycloalkyl, wherein said C1-C6alkyl, heteroaryl and C3-C10cycloalkyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, —OCH2CH2OH, carboxy and hydroxy.
164. The compound according to any one of clauses 1-163, wherein R26, R27, R46, R47, R49, R50, R51, R53 and R52 are each independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three substituents independently selected from the group consisting of fluorine, chlorine, methyl, ethyl, methoxy, ethoxy, —OCH2CH2OH, carboxy and hydroxy.
165. The compound according to any one of clauses 1-164, wherein R54, R55, R56 and R57 are each independently selected from the group consisting of hydrogen, halogen, —CN, trifluoromethyl, —OCH2CH2OH, hydroxyl.
166. The compound according to any one of clauses 1-164, wherein R54, R55, R56 and R57 are each independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three substituents independently selected from the group consisting of fluorine, chlorine methyl, ethyl, methoxy, ethoxy, —OCH2CH2OH, carboxy and hydroxy.
167. The compound according to any one of clauses 1-166, wherein R48 is selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl wherein said methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl are optionally substituted with one or two substituents independently selected from the group consisting of fluorine and hydroxy.
168. The compound according to any one of clauses 1-167, wherein R49 is selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl wherein said methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl are optionally substituted with one or two substituents independently selected from the group consisting of fluorine and hydroxy.
169. The compound according to any one of clauses 1-167, wherein R49 is H and R48 is selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl wherein said methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl are optionally substituted with one or two substituents independently selected from the group consisting of fluorine and hydroxy.
170. The compound according to any one of clauses 1-167, wherein R48 is H and R49 is selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl wherein said methyl, ethyl and isopropyl, tetrahydropyrane, cyclohexyl and cyclopentyl are optionally substituted with one or two substituents independently selected from the group consisting of fluorine and hydroxy.
171. The compound according to any one of clauses 1-167, wherein R48 and R49 together with the nitrogen to which they are attached form a piperidinyl, pyrrolidinyl and morpholinyl ring, wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy and fluoride.
172. The compound according to any one of clauses 1-171, wherein R58 are each independently selected from selected from the group consisting of halogen, —CN, hydroxy, oxo, —C(═O)OH, —S(═O)2R59, —S—NR60R61, S(═O)2NR60R61, cyclopropyl, —OR59, —SR59, C1-C6alkyl, —C(═O)NR60R61, —NR60C(═O)NR61R60, —NR60S(═O)2R59 and —NC(═O)R59.
173. The compound according to any one of clauses 1-171, wherein R58 is selected from the group consisting of fluorine, chlorine, —CN, hydroxy, oxo, —C(═O)OH, —S(═O)2R59, —S(═O)2NR60R61, cyclopropyl, —OR59, —SR59, methyl, ethyl, isopropyl, —C(═O)NR60R61, —NR60C(═O)NR61R60, —NR60S(═O)2R59 and —NC(═O)R59.
174. The compound according to any one of clauses 1-171, wherein R58 are each independently selected from selected from the group consisting of fluorine, chlorine, —CN, hydroxy, oxo, —C(═O)OH, —S(═O)2R59, cyclopropyl, —OR59, methyl, ethyl, isopropyl and —C(═O)NR60R61.
175. The compound according to any one of clauses 1-171, wherein R58 are each independently selected from selected from the group consisting of —S(═O)2NR60R61, —SR59, —NR60C(═O)NR61R60, —NR60S(═O)2R59 and —NC(═O)R59.
176. The compound according to any one of clauses 1-175, wherein R59 is selected from the group consisting of hydrogen, C1-C6alkyl and C3-C10cycloalkyl wherein said —C6alkyl, C3-C10cycloalkyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy trifluoromethyl and hydroxy.
177. The compound according to any one of clauses 1-175, wherein R59 is selected from the group consisting of hydrogen, phenyl and heteroaryl, wherein said, phenyl and heteroaryl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy and hydroxy.
178. The compound according to any one of clauses 1-175, wherein R59 is selected from the group consisting of hydrogen, methyl, ethyl and isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, phenyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said methyl, ethyl and isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, phenyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, methyl, ethyl, methoxy, ethoxy and hydroxy.
179. The compound according to any one of clauses 1-178, wherein R60 are each independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, and heteroaryl, wherein said methyl, ethyl, isopropyl, tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, and heteroaryl are optionally substituted with one or two substituents independently selected from the group consisting of fluorine, chlorine and hydroxy.
180. The compound according to any one of clauses 1-178, wherein R60 are each independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, wherein said methyl, ethyl, isopropyl and cyclopropyl are optionally substituted with one or two substituents independently selected from the group consisting of fluorine, chlorine and hydroxy.
181. The compound according to any one of clauses 1-180, wherein R61 are each independently selected from the group consisting of hydrogen, C1-C6alkyl, C3-C10heterocyclyl, C3-C10cycloalkyl and heteroaryl, wherein said C1-C6alkyl, C3-C10heterocyclyl, C3-C10cycloalkyl and heteroaryl are optionally substituted with one or two substituents independently selected from the group consisting of halogen and hydroxy.
182. The compound according to any one clauses 1-181, wherein R61 are each independently selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, and heteroaryl, wherein said methyl, ethyl, isopropyl, tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, and heteroaryl are optionally substituted with one or two substituents independently selected from the group consisting of fluorine, chlorine and hydroxy.
183. The compound according to any one of clauses 1-182, wherein R93 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, phenyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl, phenyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three independently selected R58.
184. The compound according to any one of clauses 1-182, wherein R93 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, tetrahydropyranyl, piperidinyl, morpholinyl, phenyl, pyrimidinyl and pyridinyl, wherein said methyl, ethyl, isopropyl, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, tetrahydropyranyl, piperidinyl, morpholinyl, phenyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three independently selected R58.
185. The compound according to any one of clauses 1-184, wherein R94 and R95 are each independently selected from the group consisting of hydrogen, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three substituents independently selected from the group consisting of fluorine, chlorine, methyl, ethyl and hydroxy.
186. The compound according to any one of clauses 1-184, wherein R94 is hydrogen and R95 are selected from the group consisting of hydrogen, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl, wherein said cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl, imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl are optionally substituted with one, two or three substituents independently selected from the group consisting of fluorine, chlorine, methyl, ethyl and hydroxy.
187. The compound according to any one of clauses 1-184, wherein R94 and R95 together with the nitrogen to which they are attached form a piperidinyl, pyrrolidinyl and morpholinyl ring, wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy or fluorine.
188. The compound according to any one of clauses 1-184, wherein R94 and R95 together with the nitrogen to which they are attached form a piperidinyl and pyrrolidinyl ring, wherein said ring optionally is substituted with one or two substituents independently selected from the group consisting of hydroxy or fluorine.
189. The compound according to any one of clauses 1-188, wherein R62 is selected from the group consisting of fluoride, chloride, —C(═O)OH, —CH(OH)—R47, —C(═O)—NR48R49, —NR48C(═O)R46, —SR49, —S(═O)2R50, —S(═O)2NR48R49, —NR48S(═O)2R50, —NR48C(═O)—NR48R49, —C═C—R51R52, —C≡C—R53, and CH2CH2OH, —CH2CH2OH.
190. The compound according to any one of clauses 1-188, wherein R62 is selected from the group consisting of C3-C10heterocyclyl substituted with R54, C3-C10cycloalkyl substituted with R55, aryl substituted with R56 and R57 and heteroaryl substituted with R56 and R57.
191. The compound according to any one clauses 1-188, wherein R62 is selected from the group consisting of fluorine, chlorine, —CH(OH)-cyclopropyl, —C(═O)—NR48R49, —NR48C(═O)R46, —S(═O)2R50, —S(═O)2NR48R49, —NR48S(═O)2R50, —NR48C(═O)—NR48R49, CH2CH2OH, —CH2CH2OH.
192. The compound according to any one of clauses 1-188, wherein R62 is selected from the group consisting of tetrahydropyranyl, piperidinyl, pyrrolidinyl, morpholinyl substituted with R54, cyclopropyl, cyclobutyl, cyclohexyl, cyclopentyl substituted with R55, phenyl substituted with R56 and R57 and imidazolyl, pyrazolyl, isoxazolyl, pyridazinyl, pyrazinyl, pyrimidinyl and pyridinyl substituted with R56 and R57.
193. The compound according to any one of clauses 1-192, wherein R63 is selected from the group consisting of hydrogen, fluoride, chloride, hydroxy, oxo, —S(═O)2R59, —S(═O)2NR60R61, —S(═O)NR60R61 cyclopropyl, —OR59, methyl, ethyl, isopropyl, —C(═O)NR60R61, —NR60C(═O)NR61R60; —NR60S(═O)2R59, and —N(C═O)R59.
194. The compound according to any one of clauses 1-192, wherein R63 is selected from the group consisting of hydrogen, fluoride, chloride, hydroxy, oxo, —S(═O)2R59, —S(═O)2NR60R61, —S(═O)NR60R61 cyclopropyl, —OR59, methyl, ethyl, isopropyl and —C(═O)NR60R61.
195. The compound according to any one of clauses 1-192, wherein R63 is selected from the group consisting of hydrogen, fluoride, chloride, trifluoromethyl, hydroxy, oxo, —S(═O)2cyclopropyl, —S(═O)2methyl, cyclopropyl, —OR59, methyl, ethyl and isopropyl.
196. A compound according to any one of clauses 1-195, wherein said compound is selected from the group consisting of N-(5-Hydroxy-adamantan-2-yl)-N-methyl-3-phenethyloxy-benzamide, N-(5-Hydroxy-adamantan-2-yl)-3-phenethyloxy-benzamide, 3-Cyclohexylmethoxy-N-(5-hydroxy-adamantan-2-yl)-N-methyl-benzamide, N-(5-Hydroxy-adamantan-2-yl)-N-methyl-3-(1-methyl-butoxy)-benzamide, N-(5-Hydroxy-adamantan-2-yl)-3-methoxy-N-methyl-benzamide, N-(5-Hydroxy-adamantan-2-yl)-N-methyl-3-(2-pyridin-2-yl-ethoxy)-benzamide, N-(5-Hydroxy-adamantan-2-yl)-3-(2-pyridin-2-yl-ethoxy)-benzamide, 3-Benzyloxy-N-(5-hydroxy-adamantan-2-yl)-benzamide, N-(5-Hydroxy-adamantan-2-yl)-3-(2-morpholin-4-yl-ethoxy)-benzamide, 4-{2-[3-(5-Hydroxy-adamantan-2-ylcarbamoyl)-phenoxy]-ethyl}-piperidine-1-carboxylic acid isopropylamide, 3-[2-(1-Cyclopropanesulfonyl-piperidin-4-yl)-ethoxy]-N-(5-hydroxy-adamantan-2-yl)-benzamide, 3-(6-Chloro-pyridin-3-ylmethoxy)-N-(5-hydroxy-adamantan-2-yl)-benzamide, N-(5-Hydroxy-adamantan-2-yl)-3-(tetrahydro-pyran-4-ylmethoxy)-benzamide, N-(5-Hydroxy-adamantan-2-yl)-3-[2-(tetrahydro-pyran-4-yl)-ethoxy]-benzamide, N-(5-Hydroxy-adamantan-2-yl)-3-[2-(2-oxo-pyrrolidin-1-yl)-ethoxy]-benzamide, N-(5-Hydroxy-adamantan-2-yl)-N-methyl-3-(tetrahydro-pyran-4-yloxy)-benzamide′, (3-Hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-[3-(tetrahydro-pyran-4-ylmethoxy)-phenyl]-methanone, (3-Hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-{3-[2-(tetrahydro-pyran-4-yl)-ethoxy]-phenyl}-methanone, (3-Hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-[3-(4-hydroxy-cyclohexylmethoxy)-phenyl]-methanone.
197. A compound according to any one of clauses 1-196, which is an agent useful for the treatment, prevention and/or prophylaxis of any conditions, disorders and diseases wherein a modulation or an inhibition of the activity of 11βHSD1 is beneficial.
198. A compound according to any one of the clauses 1-196, which is an agent useful for the treatment, prevention and/or prophylaxis of any conditions, disorders and diseases that are influenced by intracellular glucocorticoid levels.
199. A compound according to any one of the clauses 1-196, which is an agent useful for the treatment, prevention and/or prophylaxis of conditions, disorders or diseases selected from the group consisting of the metabolic syndrome, insulin resistance, dyslipidemia, hypertension and obesity.
200. A compound according to any one of the clauses 1-196, which is an agent useful for the treatment, prevention and/or prophylaxis of type 2 diabetes, impaired glucose tolerance (IGT), impaired fasting glucose (IFG).
201. A compound according to any one of the clauses 1-196, which is an agent useful for the delaying or prevention of the progression from IGT into type 2 diabetes.
202. A compound according to any one of the clauses 1-196, which is an agent useful for delaying or prevention of the progression of the metabolic syndrome into type 2 diabetes.
203. A compound according to any one of the clauses 1-196, which is an agent useful for the treatment, prevention and/or prophylaxis of adverse effects of glucocorticoid receptor agonist treatment or therapy.
204. A pharmaceutical composition comprising, as an active ingredient, at least one compound according to any one of the clauses 1-196 together with one or more pharmaceutically acceptable carriers or excipients.
205. The pharmaceutical composition according to clause 204 which is for oral, nasal, buccal, transdermal, pulmonal or parenteral administration.
206. The pharmaceutical composition according to clause 204 or 205 in unit dosage form, comprising from 0.05 mg to 2000 mg/day, from 0.1 mg to 1000 mg or from 0.5 mg to 500 mg per day of the compound according to anyone of the clauses 1-196.
207. A use of a compound according to any of the clauses 1-196, for the preparation of a pharmaceutical composition for the treatment, prevention and/or prophylaxis of any conditions, disorders and diseases wherein a modulation or an inhibition of the activity of 11βHSD1 is beneficial.
208. A use of a compound according to any of the clauses 1-196, for the preparation of a pharmaceutical composition for the treatment, prevention and/or prophylaxis of any conditions, disorders and diseases that are influenced by intracellular glucocorticoid levels.
209. A use of a compound according to any of the clauses 1-196, for the preparation of a pharmaceutical composition for the treatment, prevention and/or prophylaxis of conditions, disorders or diseases selected from the group consisting of the metabolic syndrome, insulin resistance, dyslipidemia, hypertension and obesity.
210. A use of a compound according to any of the clauses 1-196, for the preparation of a pharmaceutical composition for the treatment, prevention and/or prophylaxis of type 2 diabetes, impaired glucose tolerance (IGT), impaired fasting glucose (IFG).
211. A use of a compound according to any of the clauses 1-196, for the preparation of a pharmaceutical composition for the delaying or prevention of the progression from IGT to type 2 diabetes.
212. A use of a compound according to any of the clauses 1-196, for the preparation of a pharmaceutical composition for the delaying or prevention of the progression of the metabolic syndrome into type 2 diabetes.
213. A use of a compound according to any of the clauses 1-196, for the preparation of a pharmaceutical composition for the treatment, prevention and/or prophylaxis of adverse effects of glucocorticoid receptor agonist treatment or therapy.
214. A method for the treatment, prevention and/or prophylaxis of any conditions, disorders or diseases wherein a modulation or an inhibition of the activity of 11βHSD1 is beneficial, the method comprising administering to a subject in need thereof an effective amount of a compound according to any one of clauses 1-196.
215. The method according to clause 214 wherein the conditions, disorders or diseases are selected from the group consisting of the metabolic syndrome, insulin resistance, dyslipidemia, hypertension and obesity.

## Claims

1. A method of treating Cushing's disease comprising administering to a subject in need thereof an effective amount of a compound, wherein the compound is a compound of Formula (I) or a pharmaceutically acceptable salt thereof:




wherein:
R1 is hydrogen;
R2 is 5-hydroxy-adamantan-2-yl;
R4 is hydrogen;
R5 is hydrogen; and
Y is selected from the group consisting of 2-[1-(carboxylic acid isopropylamide)-piperidin-4-yl]-ethoxy, 6-chloro-pyridin-3-ylmethoxy, tetrahydropyran-4-yl-methoxy, 2-(2-oxo-pyrrolidin-1-yl)-ethoxy, 5-chloro-pyridin-2-yloxy, 6-bromo-pyridin-3-yloxy, phenethyloxy, 2-(tetrahydropyran-4-yl)-ethoxy, benzyloxy, 2-(1-cyclopropane-sulfonyl-piperidin-4-yl)-ethoxy, and 4-fluorobenzyloxy.

2. The method of claim 1, wherein the compound is 4-{2-[3-(5-Hydroxy-adamantan-2-ylcarbamoyl)-phenoxy]-ethyl}-piperidine-1-carboxylic acid isopropylamide or a pharmaceutically acceptable salt thereof.

3. The method of claim 1, wherein the compound is 3-(6-Chloro-pyridin-3-ylmethoxy)-N-(5-hydroxy-adamantan-2-yl)-benzamide or a pharmaceutically acceptable salt thereof.

4. The method of claim 1, wherein the compound is N-(5-Hydroxy-adamantan-2-yl)-3-(tetrahydro-pyran-4-ylmethoxy)-benzamide or a pharmaceutically acceptable salt thereof.

5. The method of claim 1, wherein the compound is N-(5-Hydroxy-adamantan-2-yl)-3-[2-(2-oxo-pyrrolidin-1-yl)-ethoxy]-benzamide or a pharmaceutically acceptable salt thereof.

6. The method of claim 1, wherein the compound is 3-(5-Chloro-pyridin-2-yloxy)-N-(5-hydroxy-adamantan-2-yl)-benzamide or a pharmaceutically acceptable salt thereof.

7. The method of claim 1, wherein the compound is 3-(6-Bromo-pyridin-3-yloxy)-N-(5-hydroxy-adamantan-2-yl)-benzamide or a pharmaceutically acceptable salt thereof.

8. The method of claim 1, wherein the compound is N-(5-Hydroxy-adamantan-2-yl)-3-phenethyloxy-benzamide or a pharmaceutically acceptable salt thereof.

9. The method of claim 1, wherein the compound is N-(5-Hydroxy-adamantan-2-yl)-3-[2-(tetrahydro-pyran-4-yl)-ethoxy]-benzamide or a pharmaceutically acceptable salt thereof.

10. The method of claim 1, wherein the compound is 3-Benzyloxy-N-(5-hydroxy-adamantan-2-yl)-benzamide or a pharmaceutically acceptable salt thereof.

11. The method of claim 1, wherein the compound is 3-[2-(1-Cyclopropane-sulfonyl-piperidin-4-yl)-ethoxy]-N-(5-hydroxy-adamantan-2-yl)-benzamide or a pharmaceutically acceptable salt thereof.

12. The method of claim 1, wherein the compound is 3-(4-Fluoro-benzyloxy)-N-(5-hydroxy-adamantan-2-yl)-benzamide or a pharmaceutically acceptable salt thereof.

13. A method of treating retinopathy comprising administering to a subject in need thereof an effective amount of a compound, wherein the compound is a compound of Formula (I) or a pharmaceutically acceptable salt thereof:




wherein:
R1 is hydrogen;
R2 is 5-hydroxy-adamantan-2-yl;
R4 is hydrogen;
R5 is hydrogen; and
Y is selected from the group consisting of 2-[1-(carboxylic acid isopropylamide)-piperidin-4-yl]-ethoxy, 6-chloro-pyridin-3-ylmethoxy, tetrahydropyran-4-yl-methoxy, 2-(2-oxo-pyrrolidin-1-yl)-ethoxy, 5-chloro-pyridin-2-yloxy, 6-bromo-pyridin-3-yloxy, phenethyloxy, 2-(tetrahydropyran-4-yl)-ethoxy, benzyloxy, 2-(1-cyclopropane-sulfonyl-piperidin-4-yl)-ethoxy, and 4-fluorobenzyloxy.

14. The method of claim 13, wherein the compound is 4-{2-[3-(5-Hydroxy-adamantan-2-ylcarbamoyl)-phenoxy]-ethyl}-piperidine-1-carboxylic acid isopropylamide or a pharmaceutically acceptable salt thereof.

15. The method of claim 13, wherein the compound is 3-(6-Chloro-pyridin-3-ylmethoxy)-N-(5-hydroxy-adamantan-2-yl)-benzamide or a pharmaceutically acceptable salt thereof.

16. The method of claim 13, wherein the compound is N-(5-Hydroxy-adamantan-2-yl)-3-(tetrahydro-pyran-4-ylmethoxy)-benzamide or a pharmaceutically acceptable salt thereof.

17. The method of claim 13, wherein the compound is N-(5-Hydroxy-adamantan-2-yl)-3-[2-(2-oxo-pyrrolidin-1-yl)-ethoxy]-benzamide or a pharmaceutically acceptable salt thereof.

18. The method of claim 13, wherein the compound is 3-(5-Chloro-pyridin-2-yloxy)-N-(5-hydroxy-adamantan-2-yl)-benzamide or a pharmaceutically acceptable salt thereof.

19. The method of claim 13, wherein the compound is 3-(6-Bromo-pyridin-3-yloxy)-N-(5-hydroxy-adamantan-2-yl)-benzamide or a pharmaceutically acceptable salt thereof.

20. The method of claim 13, wherein the compound is N-(5-Hydroxy-adamantan-2-yl)-3-phenethyloxy-benzamide or a pharmaceutically acceptable salt thereof.

21. The method of claim 13, wherein the compound is N-(5-Hydroxy-adamantan-2-yl)-3-[2-(tetrahydro-pyran-4-yl)-ethoxy]-benzamide or a pharmaceutically acceptable salt thereof.

22. The method of claim 13, wherein the compound is 3-Benzyloxy-N-(5-hydroxy-adamantan-2-yl)-benzamide or a pharmaceutically acceptable salt thereof.

23. The method of claim 13, wherein the compound is 3-[2-(1-Cyclopropane-sulfonyl-piperidin-4-yl)-ethoxy]-N-(5-hydroxy-adamantan-2-yl)-benzamide or a pharmaceutically acceptable salt thereof.

24. The method of claim 13, wherein the compound is 3-(4-Fluoro-benzyloxy)-N-(5-hydroxy-adamantan-2-yl)-benzamide or a pharmaceutically acceptable salt thereof.