Exhibit
10.28


 


THE
SECURITIES TO BE ISSUED PURSUANT TO THIS AGREEMENT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (“SECURITIES
ACT”), OR ANY OTHER APPLICABLE STATE SECURITIES LAWS AND MAY NOT BE OFFERED OR SOLD UNLESS REGISTERED THEREUNDER OR UNLESS
AN EXEMPTION FROM SUCH REGISTRATION IS AVAILABLE.


 


SUBSCRIPTION
AGREEMENT


 


Shuttle
Pharmaceuticals Holdings, Inc.


One
Research Court, Suite 450


Rockville,
Maryland 20850


Attn:
Anatoly Dritschilo, M.D.


Chief
Executive Officer


 


Ladies
and Gentlemen:


 


Subscription.
The undersigned (sometimes referred to herein as the “Investor”) hereby subscribes for and agrees to purchase the
principal amount of the Notes and Warrants (as defined below) of Shuttle Pharmaceuticals Holdings, Inc., a Delaware corporation (the
“Company”), for the purchase price (the “Purchase Price”) set forth on the signature page hereto
(collectively, the “Offering Documents”). Terms not defined herein are as defined in the Offering Documents. The Company
is seeking to raise, through a private placement of the Notes pursuant to Rule 506(b) promulgated under the Securities Act of 1933, as
amended, $500,000 (the “Offering Amount”) in this Offering. Boustead and the Company, in their sole discretion, may
accept subscriptions in excess of the Maximum Offering Amount. The minimum amount of investment required from any one subscriber to participate
in this Offering is $250,000, however, the Company reserves the right, in its sole discretion, to accept subscriptions less than this
amount. All references to $ or “dollar(s)” means United States dollars. The undersigned acknowledges that the Company has
engaged Boustead Securities, LLC (“Boustead” or “Placement Agent”) as its exclusive placement agent
in connection with this offering.


 


	1.	Description of Securities; Description of Company
  and Risk Factors.




 


	 	a.	Description
    of Securities. The Company is offering (the “Offering”) to the Investor in the minimum subscription amount
    of $250,000, however, the Company reserves the right, in its sole discretion, to accept subscriptions less than this amount, units
    (the “Units”) consisting of the Company’s (i) 10% unsecured promissory notes (the “Notes” or
    a “Note”), which Notes shall be due upon the earlier of 12 months from the date of execution or completion of
    the Company’s initial public offering and (ii) warrants to purchase Common Stock, with an exercise price of $1.00 per share
    (the “Warrants”), which Warrants shall be equal to 100% of the principal value of the Note. The Notes and Warrants
    shall be substantially in the form attached hereto as Exhibit A and Exhibit B, respectively.
	 	 	 
	 	 	This
    Offering is being conducted in advance of the Company’s intended initial public offering (“IPO”) of our
    common stock, par value $0.00001per share (the “Common Stock”), and listing our Common Stock for trading on the
    Nasdaq Capital Market or other national securities exchange.
	 	 	 
	 	 	Under
    our engagement letter with Boustead, dated as of November 10, 2021 (the “Engagement Letter”), Boustead has been
    engaged as our exclusive financial advisor for the 18-month term of the Engagement Letter. In addition, Boustead has expressed its
    intent to enter into an Underwriting Agreement with the Company to act as the lead underwriter for the proposed IPO on a “firm
    commitment” basis. There can be no assurance that we and Boustead will be able to agree on the terms of such Underwriting Agreement
    or that our proposed IPO will be successfully consummated.


 




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	 	 	The
    Notes, Warrants and shares issuable upon exercise of the Warrants (the “Warrant Shares”) are sometimes referred
    to herein as the “Securities.” The above referenced IPO, SPAC acquisition or Reverse Merger is sometimes hereinafter
    collectively referred to as a “Liquidity Event.”
	 	 	 
	 	b.	Risks
    Related to the Investment in the Securities. Investing in the Securities involves a high degree of risk. The Company has prepared
    and presented to the Investor, and the Investor has had the opportunity to review, a detailed set of risk factors concerning the
    Company, and the Investor has also been provided


 


	2.	Purchase.




 


	 	a.	I
    hereby agree to tender to Sutter Securities, Inc. (the “Escrow Agent”), by check or wire transfer of immediately
    available funds (to a bank account and related wire instructions to be provided to me on my request) made payable to “Sutter
    Securities, Inc., as Escrow Agent for Shuttle Pharmaceuticals Holdings, Inc.” for the principal amount of the Note indicated
    on the signature page hereto, an executed copy of this Subscription Agreement and an executed copy of my Investor Questionnaire attached
    as Exhibit A hereto. Funds will be held in escrow, as set forth in more detail below (the “Escrow Account”),
    pending the Initial Closing.
	 	 	 
	 	b.	The
    Offering is for a maximum offering of the Maximum Offering Amount. All subscriptions to purchase Notes will be held in a noninterest-bearing
    escrow account (the “Escrow Account”) maintained by the Escrow Agent. The subscriptions will remain in the Escrow Account
    until the Company has accepted such subscriptions and the Company, in its sole discretion, may accept subscriptions in excess of
    the Maximum Offering Amount.
	 	 	 
	 	c.	This
    Offering will continue until the earlier of (a) the sale Notes for the Maximum Offering Amount, (b) December 31, 2021, or such extension
    date agreed to, in their sole discretion, by the Company and Boustead (the “Termination Date”). Upon the earlier
    of a “Closing” (defined below) on my subscription or completion of the Offering, I will be notified promptly by the Company
    as to whether my subscription has been accepted by the Company.


 


	3.	Acceptance or Rejection of Subscription.




 


	 	a.	I
    understand and agree that the Company reserves the right to reject this subscription for the Securities, in whole or in part, for
    any reason and at any time prior to the “Closing” (defined below) of my subscription.
	 	 	 
	 	b.	In
    the event the Company rejects this subscription, my subscription payment will be promptly returned to me without interest or deduction
    and this Subscription Agreement shall be of no force or effect. In the event my subscription is accepted and the Offering is completed,
    the subscription funds submitted by me shall be released to the Company.


 


4.           
Closing. The closing (“Closing”) of this Offering may occur at any time and from time to time on or before
the Termination Date. The Company may conduct an initial Closing (the “Initial Closing”) at any time after the acceptance
of an investor’s subscription and the Initial Closing will be held and all funds will be released from the Escrow Account and paid
to the Company, less professional fees and compensation paid to the Placement Agent and syndicate members, if any. Thereafter, additional
Closings will be held as funds are received up to the earlier to occur of receipt of the Maximum Offering Amount or the Termination Date.
Boustead and the Company, in their sole discretion, may accept subscriptions in excess of the Maximum Offering Amount. All subscriptions
will be placed in escrow with the Escrow Agent. If, for any reason, at the Company’s sole discretion, an investors subscription
is rejected the subscribers escrowed funds will be returned to subscribers, without interest or deduction. The Securities subscribed
for herein shall not be deemed issued to or owned by me until one copy of this Subscription Agreement has been executed by me and countersigned
by the Company and the Closing with respect to such Securities has occurred.


 




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5.           
Disclosure. Because this offering is limited to accredited investors as defined in Section 2(15) of the Securities Act, and
Rule 501 promulgated thereunder, in reliance upon the exemption contained in Section 4(a)(2) of the Securities Act and applicable state
securities laws, the Securities are being sold without registration under the Securities Act. I acknowledge receipt of the Offering Documents
and represent that I have carefully reviewed and understand the Offering Documents, including all exhibits attached hereto. I have received
all information and materials regarding the Company that I have requested. I fully understand that the Company has a limited financial
and operating history and that the Securities are speculative investments which involve a high degree of risk, including the potential
loss of my entire investment. I fully understand the nature of the risks involved in purchasing the Securities and I am qualified to
make such investment based on my knowledge of and experience in investing in securities of this type. I have carefully considered the
potential risks relating to the Company and purchase of its Securities and have, in particular, reviewed each of the risks set forth
in the Offering Documents. Both my advisors and I have had the opportunity to ask questions of and receive answers from representatives
of the Company or persons acting on its behalf concerning the Company and the terms and conditions of a proposed investment in the Company
and my advisors and I have also had the opportunity to obtain additional information necessary to verify the accuracy of information
furnished about the Company. Accordingly, I have independently evaluated the risks of purchasing the Securities.


 


6.            
Investor Representations and Warranties. I acknowledge, represent and warrant to, and agree with, the Company as follows:


 


	 	a.	I
    am aware that my investment involves a high degree of risk as disclosed in the Offering Documents and have read carefully the Offering
    Documents, and I understand that by signing this Subscription Agreement I am agreeing to be bound by all of the terms and conditions
    of the Offering Documents.
	 	 	 
	 	b.	I
    acknowledge and am aware that there is no assurance as to the future performance of the Company.
	 	 	 
	 	c.	I
    acknowledge that there may be certain adverse tax consequences to me in connection with my purchase of Securities, and the Company
    has advised me to seek the advice of experts in such areas prior to making this investment.
	 	 	 
	 	d.	I
    am purchasing the Securities for my own account for investment purposes only and not with a view to or for sale in connection with
    the distribution of the Securities, nor with any present intention of selling or otherwise disposing of all or any part of the foregoing
    securities. I agree that I must bear the entire economic risk of my investment for an indefinite period of time because, among other
    reasons, the Securities have not been registered under the Securities Act or under the securities laws of any state and, therefore,
    cannot be resold, pledged, assigned or otherwise disposed of unless they are subsequently registered under the Securities Act and
    under applicable securities laws of certain states or an exemption from such registration is available. I hereby authorize the Company
    to place a restrictive legend on the Securities that are issued to me.
	 	 	 
	 	e.	I
    recognize that the Securities, as an investment, involve a high degree of risk including, but not limited to, the risk of economic
    losses from operations of the Company and the total loss of my investment. I believe that the investment in the Securities is suitable
    for me based upon my investment objectives and financial needs, and I have adequate means for providing for my current financial
    needs and contingencies and have no need for liquidity with respect to my investment in the Company.
	 	 	 
	 	f.	I
    have been given access to full and complete information regarding the Company and have utilized such access to my satisfaction for
    the purpose of obtaining information in addition to, or verifying information included in, the Offering Documents, and I have either
    met with or been given reasonable opportunity to meet with officers of the Company for the purpose of asking questions of, and receiving
    answers from, such officers concerning the terms and conditions of the offering of the Securities and the business and operations
    of the Company and to obtain any additional information, to the extent reasonably available.


 




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	 	g.	I
    have such knowledge and experience in financial and business matters as to be capable of evaluating the merits and risks of an investment
    in the Securities and have obtained, in my judgment, sufficient information from the Company to evaluate the merits and risks of
    an investment in the Company. I have not utilized any person as my purchaser representative as defined in Regulation D under the
    Securities Act in connection with evaluating such merits and risks.
	 	 	 
	 	h.	I
    have relied solely upon my own investigation in making a decision to invest in the Company.
	 	 	 
	 	i.	I
    have received no representation or warranty from the Company or any of its officers, directors, employees or agents in respect of
    my investment in the Company and I have received no information (written or otherwise) from them relating to the Company or its business
    other than as set forth in the Offering Documents. I am not participating in the offer as a result of or subsequent to: (i) any advertisement,
    article, notice or other communication published in any newspaper, magazine or similar media or broadcast over television or radio
    or (ii) any seminar or meeting whose attendees have been invited by any general solicitation or general advertising.
	 	 	 
	 	j.	I
    have had full opportunity to ask questions and to receive satisfactory answers concerning the offering and other matters pertaining
    to my investment and all such questions have been answered to my full satisfaction.
	 	 	 
	 	k.	I
    have been provided an opportunity to obtain any additional information concerning the offering and the Company and all other information
    to the extent the Company possesses such information or can acquire it without unreasonable effort or expense.
	 	 	 
	 	l.	I
    am an “accredited investor” as defined in Section 2(15) of the Securities Act and in Rule 501 promulgated thereunder
    and have attached the completed Accredited Investor Questionnaire to indicate my “accredited investor” status. I can
    bear the entire economic risk of the investment in the Securities for an indefinite period of time and I am knowledgeable about and
    experienced in making investments in the equity securities of non-publicly traded companies, including early stage companies. I am
    not acting as an underwriter or a conduit for sale to the public or to others of unregistered securities, directly or indirectly,
    on behalf of the Company or any person with respect to such securities.
	 	 	 
	 	m.	I
    understand that (1) the Securities have not been registered under the Securities Act, or the securities laws of certain states, in
    reliance on specific exemptions from registration, (2) no securities administrator of any state or the federal government has recommended
    or endorsed this offering or made any finding or determination relating to the fairness of an investment in the Company, and (3)
    the Company is relying on my representations and agreements for the purpose of determining whether this transaction meets the requirements
    of certain exemptions from registration afforded by the Securities Act and certain state securities laws.
	 	 	 
	 	n.	I
    understand that since neither the offer nor sale of the Securities has been registered under the Securities Act or the securities
    laws of any state, the Securities may not be sold, assigned, pledged or otherwise disposed of unless they are so registered or an
    exemption from such registration is available.


 




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	 	o.	I
    have had the opportunity to seek independent advice from my professional advisors relating to the suitability of an investment in
    the Company in view of my overall financial needs and with respect to the legal and tax implications of such investment.
	 	 	 
	 	p.	If
    the Investor is a corporation, company, trust, employee benefit plan, individual retirement account, Keogh Plan, or other tax-exempt
    entity, it is authorized and qualified to become an Investor in the Company and the person signing this Subscription Agreement on
    behalf of such entity has been duly authorized by such entity to do so.
	 	 	 
	 	q.	The
    information contained in my Investor Questionnaire, as well as any information which I have furnished to the Company with respect
    to my financial position and business experience, is correct and complete as of the date of this Subscription Agreement and, if there
    should be any material change in such information prior to the Closing of the offering, I will furnish such revised or corrected
    information to the Company. I hereby acknowledge and am aware that except for any rescission rights that may be provided under applicable
    laws, I am not entitled to cancel, terminate or revoke this subscription and any agreements made in connection herewith shall survive
    my death or disability.


 


7.
           Placement Agent. The Company has engaged Boustead Securities LLC,
a broker-dealer licensed with FINRA (the “Placement Agent”), as placement agent for the Offering on a reasonable best-efforts
basis. The Company anticipates that the Placement Agent and its sub-agents or syndicate members will be paid at each Closing from the
proceeds in the Escrow Account, fees including and not to exceed: a cash commission of nine percent (9%) of the gross Purchase Price
paid by Subscribers in the Offering r; a non-accountable expense allowance for certain investors of one percent (1%) of the gross purchase
price paid by Subscribers in the Offering; and will receive warrants to purchase a number of shares of Common Stock equal to ten percent
(10%) of the Common Stock underlying the Notes sold in the Offering to investors, with a term of five (5) years from the relevant Closing
Date, and at a per share exercise price equal to the conversion price of the Notes issued to the Subscribers herein (the “Placement
Agent Warrants”). Any sub-agent or syndicate member of the Placement Agent that introduces investors to the Offering will be
entitled to share in the cash fees and Placement Agent Warrants attributable to those investors as described above, pursuant to the terms
of an executed sub-agent or selected dealer agreement. The Company will also pay certain expenses of the Placement Agent.


 


8.
          Representations and Warranties of the Company. When used in this Section
8, unless the context indicates otherwise, all references to the “Company” also mean and include the direct and indirect
subsidiaries of the Company. The Company hereby represents and warrants to the Subscriber, as of the date hereof and on each Closing
Date, the following:


 


	 	a.	Organization
    and Qualification. The Company and each of its subsidiaries, if any, is a corporation or other business entity duly organized,
    validly existing and in good standing under the laws of the jurisdiction of its formation, and has the requisite corporate power
    to own its properties and to carry on its business as now being conducted. The Company and each of its subsidiaries is duly qualified
    as a foreign corporation to do business and is in good standing in every jurisdiction in which the nature of the business conducted
    by it makes such qualification necessary, except to the extent that the failure to be so qualified or be in good standing would not
    have a material adverse effect on the assets, business, financial condition, results of operations or future prospects of the Company
    and its subsidiaries taken as a whole (a “Material Adverse Effect”).


 




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	 	b.	Authorization,
    Enforcement, Compliance with Other Instruments. (i) The Company has the requisite corporate power and authority to enter into
    and perform its obligations under this Agreement, and each of the Offering Documents and to issue the Securities in accordance with
    the terms hereof, (ii) the execution and delivery by the Company of each of the Offering Documents and the consummation by it of
    the transactions contemplated hereby and thereby, including, without limitation, the issuance of the Securities have been, or will
    be at the time of execution of such Offering Document, duly authorized by the Company’s Board of Directors, and no further
    consent or authorization is, or will be at the time of execution of such Offering Document, required by the Company, its respective
    Board of Directors or its stockholders, (iii) each of the Offering Documents will be duly executed and delivered by the Company,
    (iv) the Offering Documents when executed and delivered by the Company and each other party thereto will constitute the valid and
    binding obligations of the Company enforceable against the Company in accordance with their terms, except as such enforceability
    may be limited by general principles of equity or applicable bankruptcy, insolvency, reorganization, moratorium, liquidation or similar
    laws relating to, or affecting generally, the enforcement of creditors’ rights and remedies.
	 	 	 
	 	c.	Capitalization.
    The authorized capital stock of the Company consists of 120,000,000 shares of capital stock consisting of (a) 100,000,000 shares
    of Common shares each with a par value of $0.00001 per share (the “Common Stock”), and (b) 20,000,000 shares of
    preferred stock, of which have been issued 18,587,914 shares of Common stock, 1,212.5 shares of Series A preferred stock,
    which shares are convertible into approximately 97,602 shares of Common Stock and warrants to purchase 97,602 shares of Common Stock.
    The Company also issues Common Stock, stock options, restricted stock units or other forms of equity compensation from time to time
    in lieu of salary or services rendered to the Corporation at fair market value from the Company’s equity incentive plan, pursuant
    to which it has reserved for issuance a total of 3,000,000 shares of Common Stock.
	 	 	 
	 	 	All
    of the outstanding shares of Common Stock of the Company and all of the share capital of each of the Company’s subsidiaries
    have been or will be, as of the Initial Closing, duly authorized, validly issued and are fully paid and nonassessable. No shares
    of capital stock of the Company or any of its subsidiaries will be subject to preemptive rights or any other similar rights or any
    liens or encumbrances suffered or permitted by the Company; (ii) aside from the outstanding Series A convertible preferred stock
    and warrants issuable in connection therewith, which has certain registration rights, there will be no agreements or arrangements
    under which the Company or any of its subsidiaries is obligated to register the sale of any of their securities under the Securities
    Act, and (iii) there are no securities or instruments of the Company or any of its subsidiaries containing anti-dilution or similar
    provisions, including the right to adjust the exercise, exchange or reset price under such securities, that will be triggered by
    the issuance of the Securities as described in this Agreement. Upon request, the Company will make available to the Subscriber true
    and correct copies of the Company’s Certificate of Incorporation, as amended and as in effect on the date hereof (the “Certificate
    of Incorporation”), and the Company’s By-laws, as amended as in effect on the date hereof (the “By-laws”),
    and the terms of all securities exercisable for Common Stock and the material rights of the holders thereof in respect thereto other
    than stock options issued to officers, directors, employees and consultants.
	 	 	 
	 	d.	Subsidiaries
    and Affiliates. The Company’s direct operating subsidiary is Shuttle Pharmaceuticals, Inc., a Maryland corporation.
	 	 	 
	 	e.	Issuance
    of Securities. The Securities are duly authorized and, upon issuance in accordance with the terms hereof, shall be duly issued,
    fully paid and nonassessable, and will be free and clear of all taxes, liens and charges with respect to the issue thereof.


 




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	 	f.	No
    Conflicts. The execution, delivery and performance of each of the Offering Documents by the Company, and the consummation by
    the Company of the transactions contemplated hereby and thereby will not (i) result in a violation of the Certificate of Incorporation
    or the By-laws (or equivalent constitutive document) of the Company or any of its subsidiaries or (ii) violate or conflict with,
    or result in a breach of any provision of, or constitute a default (or an event which with notice or lapse of time or both would
    become a default) under, or give to others any rights of termination, amendment, acceleration or cancellation of, any agreement,
    indenture or instrument to which the Company or any subsidiary is a party, except for those which would not reasonably be expected
    to have a Material Adverse Effect, or (iii) result in a violation of any law, rule, regulation, order, judgment or decree (including
    U.S. federal and state securities laws and regulations) applicable to the Company or any subsidiary or by which any property or asset
    of the Company or any subsidiary is bound or affected except for those which could not reasonably be expected to have a Material
    Adverse Effect. Except those which could not reasonably be expected to have a Material Adverse Effect, neither the Company nor any
    subsidiary is in violation of any term of or in default under its constating documents. Except those which could not reasonably be
    expected to have a Material Adverse Effect, neither the Company nor any subsidiary is in violation of any term of or in default under
    any material contract, agreement, mortgage, indebtedness, indenture, instrument, judgment, decree or order or any statute, rule or
    regulation applicable to the Company or any subsidiary. The business of the Company and its subsidiaries is not being conducted,
    and shall not be conducted in violation of any law, ordinance, or regulation of any governmental entity, except for any violation
    which could not reasonably be expected, individually or in the aggregate, to have a Material Adverse Effect. Except as specifically
    contemplated by this Agreement and as required under the Securities Act and any applicable state securities laws, neither the Company
    nor any of its subsidiaries is required to obtain any consent, authorization or order of, or make any filing or registration with,
    any court or governmental agency in order for it to execute, deliver or perform any of its obligations under or contemplated by this
    Agreement or the other Offering Documents in accordance with the terms hereof or thereof. Neither the execution and delivery by the
    Company of the Offering Documents, nor the consummation by the Company of the transactions contemplated hereby or thereby, will require
    any notice, consent or waiver under any contract or instrument to which the Company or any subsidiary is a party or by which the
    Company or any subsidiary is bound or to which any of their assets is subject, except for any notice, consent or waiver the absence
    of which would not reasonably be expected, individually or in the aggregate, to have a Material Adverse Effect and would not adversely
    affect the consummation of the transactions contemplated hereby or thereby. All consents, authorizations, orders, filings and registrations
    which the Company or any of its subsidiaries is required to obtain pursuant to the preceding two sentences have been or will be obtained
    or effected on or prior to the Closing.
	 	 	 
	 	g.	Absence
    of Litigation. There is no action, suit, claim, inquiry, notice of violation, proceeding (including any partial proceeding such
    as a deposition) or investigation before or by any court, public board, governmental or administrative agency, self-regulatory organization,
    arbitrator, regulatory authority, stock market, stock exchange or trading facility (an “Action”) now pending or,
    to the knowledge of the Company, threatened, against or affecting the Company or any of its subsidiaries, wherein an unfavorable
    decision, ruling or finding would (i) adversely affect the validity or enforceability of, or the authority or ability of the Company
    to perform its obligations under this Agreement or any of the other Offering Documents, or (ii) have a Material Adverse Effect.
	 	 	 
	 	h.	Acknowledgment
    Regarding Subscriber’s Purchase of the Securities. The Company acknowledges and agrees that each Subscriber is acting solely
    in the capacity of an arm’s length purchaser with respect to the Offering Documents and the transactions contemplated hereby
    and thereby. The Company further acknowledges that each Subscriber is not acting as a financial advisor or fiduciary of the Company
    (or in any similar capacity) with respect to the Offering Documents and the transactions contemplated hereby and thereby and any
    advice given by such Subscriber or any of their respective representatives or agents in connection with the Offering Documents and
    the transactions contemplated hereby and thereby is merely incidental to such Subscriber’s purchase of the Securities.
	 	 	 
	 	i.	No
    General Solicitation. Neither the Company, nor any of its “affiliates” (as defined in Rule 144 under the Securities
    Act), nor, to the knowledge of the Company, any person acting on its or their behalf, has engaged in any form of general solicitation
    or general advertising (within the meaning of Regulation D) in connection with the offer or sale of the Securities.


 




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	 	j.	No
    Integrated Offering. Neither the Company, nor any of its affiliates, nor to the knowledge of the Company, any person acting on
    its or their behalf has, directly or indirectly, made any offers or sales of any security or solicited any offers to buy any security,
    under circumstances that would require registration of the Securities under the Securities Act or cause this offering of the Securities
    to be integrated with prior offerings by the Company for purposes of the Securities Act.
	 	 	 
	 	k.	Employee
    Relations. Neither the Company nor any subsidiary is involved in any labor dispute nor, to the knowledge of the Company, is any
    such dispute threatened. Neither the Company nor any subsidiary is party to any collective bargaining agreement. The Company’s
    and/or its subsidiaries’ employees are not members of any union, and the Company believes that its and its subsidiaries’
    relationship with their respective employees is good.
	 	 	 
	 	l.	Permits.
    The Company and its subsidiaries have all authorizations, approvals, clearances, licenses, permits, certificates or exemptions (including
    manufacturing approvals and authorizations, pricing and reimbursement approvals, labeling approvals, registration notifications or
    their foreign equivalent) issued by any regulatory authority or governmental agency (collectively, “Permits”)
    required to conduct their respective businesses as currently conducted except to the extent that the failure to have such Permits
    would not have a Material Adverse Effect. The Company or its subsidiaries have fulfilled and performed in all material respects their
    obligations under each Permit, and, as of the date hereof, to the knowledge of the Company, no event has occurred or condition or
    state of facts exists which would constitute a breach or default or would cause revocation or termination of any such Permit except
    to the extent that such breach, default, revocation or termination would not have a Material Adverse Effect.
	 	 	 
	 	m.	Title.
    Each of the Company and its subsidiaries has good and marketable title to all of its real and personal property and assets, free
    and clear of any material restriction, mortgage, deed of trust, pledge, lien, security interest or other charge, claim or encumbrance
    which would have a Material Adverse Effect. With respect to properties and assets it leases, each of the Company and its subsidiaries
    is in material compliance with such leases and holds a valid leasehold interest free of any liens, claims or encumbrances which would
    have a Material Adverse Effect.
	 	 	 
	 	n.	Rights
    of First Refusal. The Company is not obligated to offer the Securities offered hereunder on a right of first refusal basis or
    otherwise to any third parties including, but not limited to, current or former stockholders of the Company, underwriters, brokers,
    agents or other third parties.
	 	 	 
	 	o.	Reliance.
    The Company acknowledges that the Subscriber is relying on the representations and warranties made by the Company hereunder and that
    such representations and warranties are a material inducement to the Subscriber purchasing the Securities. The Company further acknowledges
    that without such representations and warranties of the Company made hereunder, the Subscribers would not enter into this Agreement.
	 	 	 
	 	p.	Brokers’
    Fees. Aside from the fees owed to the Placement Agent, as set forth above, the Company does not have any liability or obligation
    to pay any fees or commissions to any broker, finder or agent with respect to the transactions contemplated by this Agreement.
	 	 	 
	 	q.	Off-Balance
    Sheet Arrangements. There is no transaction, arrangement, or other relationship between the Company or any subsidiary and an
    unconsolidated or other off- balance sheet entity that is required to be disclosed by the Company in the Financial Statements and
    is not so disclosed or that otherwise would have a Material Adverse Effect.


 




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	 	r.	Investment
    Company. The Company is not required to be registered as, and is not an affiliate of, and immediately following the Closing will
    not be required to register as, an “investment company” within the meaning of the Investment Company Act of 1940, as
    amended.
	 	 	 
	 	s.	Reliance.
    The Company acknowledges that the Purchaser is relying on the representations and warranties made by the Company hereunder and that
    such representations and warranties are a material inducement to the Purchaser purchasing the Notes. The Company further acknowledges
    that without such representations and warranties of the Company made hereunder, the Purchaser would not enter into this Agreement.


 


9.           
Indemnification. I hereby agree to indemnify and hold harmless the Company and its officers, directors, shareholders, employees,
agents, advisors and counsel, and Boustead Securities, LLC and its officers, directors, shareholders, employees, agents, advisors and
counsel, against any and all losses, claims, demands, liabilities and expenses (including reasonable legal or other expenses, including
reasonable attorneys’ fees) incurred by each such person in connection with defending or investigating any such claims or liabilities,
whether or not resulting in any liability to such person, to which any such indemnified party may become subject under the Securities
Act, under any other statute, at common law or otherwise, insofar as such losses, claims, demands, liabilities and expenses (a) arise
out of or are based upon any untrue statement or alleged untrue statement of a material fact made by me and contained in this Subscription
Agreement or my Investor Questionnaire, or (b) arise out of or are based upon any breach by me of any representation, warranty, or agreement
made by me contained herein or therein.


 


10.         
Severability. In the event any parts of this Subscription Agreement are found to be void, the remaining provisions of this
Subscription Agreement shall nevertheless be binding with the same force and effect as though the void parts were deleted.


 


11.         
Choice of Law and Jurisdiction. This Subscription Agreement shall be governed by the laws of the State of Delaware as applied
to contracts entered into and to be performed entirely within the State of Delaware. Any action arising out of this Subscription Agreement
shall be brought exclusively in a court of competent jurisdiction in Montgomery County, Maryland, and the parties hereby irrevocably
waive any objections they may have to venue in Montgomery County, Maryland.


 


12.         
Counterparts. This Subscription Agreement may be executed in one or more counterparts, each of which shall be deemed an original
but all of which together shall constitute one and the same instrument. The execution of this Subscription Agreement may be by actual
or facsimile signature.


 


13.         
Benefit. This Subscription Agreement shall be binding upon and inure to the benefit of the parties hereto.


 


14.         
Notices and Addresses. All notices, offers, acceptance and any other acts under this Subscription Agreement (except payment)
shall be in writing, and shall be sufficiently given if delivered to the addresses in person, by Federal Express or similar courier delivery
or by electronic facsimile delivered to the party’s email address, as follows:


 


	Investor:	 	At
                                            the address designated on the signature page of this Subscription Agreement.

     

    Or
    the email address on the signature page of the Subscription Agreement

	The
    Company:	 	Shuttle
                                            Pharmaceuticals Holdings, Inc.

    One
    Research Court, Suite 450 Rockville, Maryland 20850




 


With
a copy to [  ]@shuttlepharma.com


 


or
to such other address as any of them, by notice to the others may designate from time to time. The transmission confirmation receipt
from the sender’s facsimile machine shall be conclusive evidence of successful facsimile delivery. Time shall be counted to, or
from, as the case may be, the delivery in person or by mailing.


 




    	9



     


    

 


15.        
Entire Agreement. This Subscription Agreement, together with the Offering Documents, constitutes the entire agreement between
the parties with respect to the subject matter hereof and supersedes all prior oral and written agreements between the parties hereto
with respect to the subject matter hereof. This Subscription Agreement may not be changed, waived, discharged, or terminated orally but,
rather, only by a statement in writing signed by the party or parties against which enforcement or the change, waiver, discharge or termination
is sought.


 


16.         
Section Headings. Section headings herein have been inserted for reference only and shall not be deemed to limit or otherwise
affect, in any matter, or be deemed to interpret in whole or in part, any of the terms or provisions of this Subscription Agreement.


 


17.        
Survival of Representations, Warranties and Agreements. The representations, warranties and agreements of Investor contained
herein shall survive the delivery of, and the payment for, the Securities.


 


18.         
Acceptance of Subscription. The Company may accept this Subscription Agreement at any time for all or any portion of the Securities
subscribed for by executing a copy hereof as provided and notifying me within a reasonable time thereafter.


 


RESIDENTS
OF ALL STATES: THE SECURITIES OFFERED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”),
OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION AND ARE BEING OFFERED AND SOLD IN RELIANCE ON EXEMPTIONS FROM THE REGISTRATION
REQUIREMENTS OF SAID ACT AND SUCH LAWS. THE SECURITIES ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED
OR RESOLD EXCEPT AS PERMITTED UNDER SAID ACT AND SUCH LAWS PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM. INVESTORS SHOULD BE AWARE
THAT THEY WILL BE REQUIRED TO BEAR THE FINANCIAL RISKS OF THIS INVESTMENT FOR AN INDEFINITE PERIOD OF TIME. THE SECURITIES HAVE NOT BEEN
APPROVED OR DISAPPROVED BY THE SECURITIES AND EXCHANGE COMMISSION, ANY STATE SECURITIES COMMISSION OR OTHER REGULATORY AUTHORITY, NOR
HAVE ANY OF THE FOREGOING AUTHORITIES PASSED UPON OR ENDORSED THE MERITS OF THIS OFFERING OR THE ACCURACY OR ADEQUACY OF THE OFFERING
DOCUMENTS. ANY REPRESENTATION TO THE CONTRARY IS UNLAWFUL.


 


SALES
IN FLORIDA: THE SECURITIES OFFERED HEREBY WILL BE SOLD, AND ACQUIRED, IN A TRANSACTION EXEMPT UNDER SECTION 517.061(11) OF THE FLORIDA
SECURITIES AND INVESTOR PROTECTION ACT. THE SECURITIES HAVE NOT BEEN REGISTERED UNDER SAID ACT IN THE STATE OF FLORIDA. PURSUANT TO SECTION
517.061(11) OF THE FLORIDA SECURITIES AND INVESTOR PROTECTION ACT, WHEN SALES ARE MADE TO FIVE (5) OR MORE PERSONS IN THE STATE OF FLORIDA,
ANY SALE IN THE STATE OF FLORIDA MADE PURSUANT TO SECTION 517.061(11) OF SUCH ACT IS VOIDABLE BY THE PURCHASER IN SUCH SALE (WITHOUT
INCURRING ANY LIABILITY TO THE COMPANY OR TO ANY OTHER PERSON OR ENTITY) EITHER WITHIN THREE (3) DAYS AFTER THE FIRST TENDER OF CONSIDERATION
IS MADE BY SUCH PURCHASER TO THE ISSUER, AN AGENT OF THE ISSUER, OR AN ESCROW AGENT OR WITHIN THREE (3) DAYS AFTER THE AVAILABILITY OF
THAT PRIVILEGE IS COMMUNICATED TO SUCH PURCHASER, WHICHEVER OCCURS LATER. TO VOID HIS OR HER PURCHASE, THE PURCHASER NEED ONLY SEND A
LETTER OR TELEGRAM TO THE COMPANY AT THE ADDRESS INDICATED HEREIN. ANY SUCH LETTER OR TELEGRAM SHOULD BE SENT AND POSTMARKED PRIOR TO
THE END OF THE AFOREMENTIONED THREE (3) DAY PERIOD. IT IS PRUDENT TO SEND ANY SUCH LETTER BY CERTIFIED MAIL, RETURN RECEIPT REQUESTED,
TO ASSURE THAT IT IS RECEIVED AND ALSO TO HAVE EVIDENCE OF THE TIME THAT IT WAS MAILED. SHOULD A PURCHASER MAKE THIS REQUEST ORALLY,
THAT PURCHASER MUST ASK FOR WRITTEN CONFIRMATION THAT THE REQUEST HAS BEEN RECEIVED. IF NOTICE IS NOT RECEIVED WITHIN THE
TIME LIMIT SPECIFIED HEREIN, THE FOREGOING RIGHT TO VOID THE PURCHASE SHALL BE NULL AND VOID.


 


(Remainder
of Page left intentionally blank.)


 




    	10



     


    

 


THE
AGGREGATE AMOUNT SUBSCRIBED FOR HEREBY IS:


 


$_______________principal
Notes


 


Manner
in Which Title is to be Held. (check one)


 


	—	Individual
    Ownership	—
    Community Property
	—	Joint
    Tenant with Right of Survivorship (both parties must sign)
	—	Partnership	—
    Tenants in common
	—	Corporation
    or Trust	—
    IRA or Keogh
	—	Other
    (please indicate)	 


 


 


	INDIVIDUAL
    INVESTORS	 	 	ENTITY
    INVESTORS
	 	 	 	 
	 	 	 	Name
    of entity, if any
	 	 	 	 
	Signature
    (Individual)	 	 	By:	                 
	 	 	 	*Signature
	 	 	 	Its:	 
	 	 	 	Title:	 
	Signature	(Joint)	 	 	 
	(all
    record holders must sign)	 	 		 
	 	 	 	 	 
	 	 	 	 
	Name(s)
    Typed or Printed	 	 	Name
    Typed or Printed
	 	 	 	 
	Address
    to Which Correspondence Should be Directed	 	 	Address
    to Which Correspondence Should be Directed
	 	 	 	 
	 	 	 	 
	 	 	 	 
	 	 	 	 
	City,
    State and Zip Code	 	 	City,
    State and Zip Code
	 	 	 	 
	 	 	 	 
	Email
    address for notices	 	 	Email
    address for notices
	 	 	 	 
	 	 	 	 
	Name(s)
    Typed or Tax Identification or Social Security Number	 	 	Name(s)
    Typed or Tax Identification or Social Security Number





 


*
If Securities are being subscribed for by any entity, the Certificate of Signatory on the below page must also be completed


 




    	11



     


    

 


The
foregoing subscription is accepted and the Company hereby agrees to be bound by its terms on day of______________, 2021.


 


	 	Shuttle
    Pharmaceuticals Holdings, Inc.
	 	 
	Dated:	By:	 
	 	Name:	Dr.
    Anatoly Dritschilo
	 	Its:	Chief
    Executive Officer



 



    	12



     


    

 


CERTIFICATE
OF SIGNATORY


 


(To
be completed if Securities are being subscribed for by an entity)


 


 


	I,_____________________________________,	the_________________________________
	(name of signatory)	(title)




 


	Of________________________________________	(“Entity”), a_____________________________
	(name of entity)	(type of entity)




 


Organized
under the laws of_____________ , hereby certify that I am empowered and duly authorized by the Entity to execute the Subscription Agreement
and to purchase the Securities and certify further that the Subscription Agreement has been duly and validly executed on behalf of the
Entity and constitutes a legal and binding obligation of the Entity.


 


IN
WITNESS WHEREOF, I have set my hand this_______________ day of ____________, 2021.


 


	 	 
	 	(Signature)






 




    	13



     


    

 


INSTRUCTIONS
FOR COMPLETION OF INVESTOR REPRESENTATION


AND
SUITABILITY QUESTIONNAIRE


 


	Item
    I:	Name
    and address information must be provided. Securities will be issued in the name(s) set forth in this Item and delivered to the address
    set forth in this Item. If two people are subscribing jointly, both people must provide their names and social security numbers.
    A telephone number must also be provided.
	 	 
	Item
    II:	If
    the securities are to be held in a different name than the investor and sent to a different address (i.e., an IRA or other account
    held at a brokerage firm), this Item must be completed. If the securities are to be issued and delivered directly to the entity listed
    in Item I, this Item need not be completed.
	 	 
	Item
    III:	This
    Item needs to be read by the investor, but nothing needs to be written here. The Securities are suitable for investment only by prospective
    investors who are “Accredited Investors.”


 


	Item
    IV:	A.
    Only complete this Item by checking the appropriate line if you are an individual investor.
	 	 
	 	B.
    Only complete this Item if you are an entity investor.
	 	 
	 	C.
    Only complete this Item if you are a trust investor.
	 	 
	Item
    V:	This
    Item needs to be read by the investor, but nothing needs to be written here.
	 	 
	Item
    VI:	The
    USA Freedom Act requires us to collect information on the sources of funds. Please complete section 1, add the documents requested
    in section 2 only if funds did not come from an approved country (U.S. is approved), and complete section 3.
	 	 
	Item
    VII:	You
    must thoroughly complete the Suitability Questionnaire in order for the Company and the Managing Dealer to make a determination
    whether this is a suitable investment for you.
	 	 
	Item
    VIII:	You
    must sign and date here.


 




    	1



     


    

 


INSTRUCTIONS
FOR PAYMENT


 


Review
and complete the Investor Representation and Suitability Questionnaire and deliver it


to
the email below, then send a wire transfer using the instructions below:


 


Sutter
Securities, Inc.


 


Email:
offerings@boustead1828.com


 


If
you prefer to send a wire transfer instead of a check, please mail or deliver your completed Investor Representation and Suitability
Questionnaire to the address above and send the wire transfer using these instructions:


 


Wiring
Instructions


 


Bank
Name: Banc of California


Bank
Address: 3 MacArthur Pl, Santa Ana, CA 92707


SWIFT
Code: BCLFUS66


Routing
Number: 122243774


Account
Number: 2030618919


REF:
Shuttle Pharma – [Investor Name]


 


If
you prefer to send a check instead of a wire transfer, please send a check to the account name and address below:


 


Sutter
Securities, Inc.


6
Venture, Suite 395


Irvine,
CA 92618


 


If
you need assistance, please contact:


 


Contact:
Brinson Lingenfelter


 


Email:
offerings@boustead1828.com


Phone:
949-375-6879


 




    	1



     


    

 


 



    	 



     


    




 


 



    	 



     


    




 


 



    	 



     


    




 


 



    	 



     


    

 


 



    	 



     


    




 


 



    	 



     


    

 


 



    	 



     


    

 


 



    	 



     


    




 





 



    	 



     


    




 


 



    	 



     


    




 


 



    	 



     


    







 


EXHIBIT
A


 


FORM
OF NOTE


 




    	13



     


    

 


Form
of Note


 


NEITHER
THIS NOTE NOR THE SECURITIES INTO WHICH THIS NOTE IS CONVERTIBLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR
THE SECURITIES COMMISSION OF ANY STATE. THESE SECURITIES HAVE BEEN SOLD IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES
ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION
REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS.


 


SHUTTLE
PHARMACEUTICALS HOLDINGS, INC.


 


 


10%
PROMISORRY NOTE


 


	Issuance
    Date:________________, 2021	 	Original
    Principal Amount: $______________
	Note
    No.	 	 



 


FOR
VALUE RECEIVED, Shuttle Pharmaceuticals Holdings, Inc., a Delaware corporation (“Shuttle Pharma” or the “Maker”),
hereby promises to pay to the order of________________ (the “Subscriber”), or its registered assigns (together with
the Subscriber, the “Holder”), the amount set out above as the Original Principal Amount, as reduced pursuant to the
terms hereof pursuant to redemption, conversion or otherwise (the “Principal”), when due, whether upon the Maturity
Date (as defined below), acceleration, redemption or otherwise (in each case in accordance with the terms hereof) and to pay interest
(“Interest”) on any outstanding Principal at the applicable Interest Rate from the date set out above as the Issuance
Date (the “Issuance Date”) until the same becomes due and payable, upon the Maturity Date or acceleration, conversion,
redemption or otherwise (in each case in accordance with the terms hereof).


 


The
Original Principal Amount is__________________ Dollars ($_______________). For purposes hereof, the term “Outstanding Balance”
means the Original Principal Amount, as reduced or increased, as the case may be, pursuant to the terms hereof for conversion, breach
hereof or otherwise, plus any accrued but unpaid interest, collection and enforcements costs, and any other fees or charges incurred
under this Note provided that, in the event of an optional or mandatory conversion of the Note into shares of Common Stock
(as provided herein), all accrued interest on the Principal subject to such conversion shall be waived.


 


This
Note is being issued pursuant to the terms of a subscription agreement dated as of ____ ___, 2021 between the Maker and the Subscriber
and exhibits thereto (collectively, the “Transaction Documents”). Unless otherwise defined herein, all capitalized
terms, when used in this Note, shall have the same meaning as they are defined in the Transaction Documents.


 




    	 



     


    

 


1.
GENERAL TERMS


 


(a)
Payment of Principal. Unless previously converted into shares of the common stock, $0.00001par value, of Shuttle Pharma or the
common stock of any successor in interest to the Maker (each the “Common Stock”) as contemplated hereby, this Note,
together with all accrued interest hereon at the Interest Rate, shall be due and payable on the earlier of the Company’s completion
of its IPO (as defined below) or December 31, 2022 (the “Maturity Date”). In the event that within 12 months of the
Issuance Date, the Maker shall not have consummated an initial public offering of its Common Stock and the listing or trading of its
Common Stock on a “Qualified Securities Market”, as defined below (the “IPO”).


 


(b)
Interest. Interest shall accrue from the Issuance Date on the Original Principal Amount or other outstanding Principal at an annual
rate of ten percent (10%) (the “Interest Rate”) and all accrued interest shall be fully paid on the Maturity Date
(or sooner as provided herein) to the Holder or its assignee in whose name this Note is registered on the records of the Maker regarding
registration and transfers of Notes in cash. However, in the event of an optional or mandatory conversion of the Note into shares of
Common Stock (as provided herein), all accrued interest on the Principal subject to such conversion shall be waived.


 


2.
EVENTS OF DEFAULT.


 


Whenever
used herein, an “Event of Default” means the occurrence and continuation of any one of the following events, whatever
the reason, and whether it shall be voluntary or involuntary, or effected by operation of law or pursuant to any judgment, decree or
order of any court, or any order, rule or regulation of any administrative or governmental body:


 


(a)
The Maker’s failure to pay to the Holder any amount of Principal, Interest, or other amounts when and as due under this Note; or


 


(b)
A Conversion Failure as defined in Section 3(d)(ii); or


 


(c)
A material breach by Shuttle Pharma of any material representation, warranty or covenant contained in the Transaction Documents or a
material breach by Shuttle Pharma of any material representation, warranty or covenant contained in the Purchase Agreement, that, if
capable of cure, is not cured within 30 days from the date such breach has occurred; or


 


(d)
The Maker or any subsidiary of the Maker shall commence, or there shall be commenced against the Maker or any subsidiary of the Maker
under any applicable bankruptcy or insolvency laws as now or hereafter in effect or any successor thereto, or the Maker or any subsidiary
of the Maker commences any other proceeding under any reorganization, arrangement, adjustment of debt, relief of debtors, dissolution,
insolvency or liquidation or similar law of any jurisdiction whether now or hereafter in effect relating to the Maker or any subsidiary
of the Maker or there is commenced against the Maker or any subsidiary of the Maker any such bankruptcy, insolvency or other proceeding
which remains undismissed for a period of ninety-one (91) days; or the Maker or any subsidiary of the Maker is adjudicated insolvent
or bankrupt; or any order of relief or other order approving any such case or proceeding is entered; or the Maker or any subsidiary of
the Maker suffers any appointment of any custodian, private or court appointed receiver or the like for it or any substantial part of
its property which continues undischarged or unstayed for a period of ninety-one (91) days; or the Maker or any subsidiary of the Maker
makes a general assignment for the benefit of creditors; or the Maker or any subsidiary of the Maker shall fail to pay, or shall state
that it is unable to pay, or shall be unable to pay, its debts generally as they become due; or the Maker or any subsidiary of the Maker
shall call a meeting of its creditors with a view to arranging a composition, adjustment or restructuring of its debts; or the Maker
or any subsidiary of the Maker shall by any act or failure to act expressly indicate its consent to, approval of or acquiescence in any
of the foregoing; or any corporate or other action is taken by the Maker or any subsidiary of the Maker for the purpose of effecting
any of the foregoing.


 




    	 



     


    

 


3.
PREPAYMENT. This Note may note may not be prepaid by Shuttle Pharma.


 


4.
REISSUANCE OF THIS NOTE.


 


Upon
receipt by the Maker of evidence reasonably satisfactory to the Maker of the loss, theft, destruction or mutilation of this Note, and,
in the case of loss, theft or destruction, of any indemnification undertaking by the Holder to the Maker in customary form and, in the
case of mutilation, upon surrender and cancellation of this Note, the Maker shall execute and deliver to the Holder a new Note representing
the outstanding Principal.


 


5.
NOTICES. Any notices, consents, waivers or other communications required or permitted to be
given under the terms shall be handled according to the Notice clause in the Subscription Agreement. The addresses for such communications
shall be:


 


If
to the Maker:


Dr.
Anatoly Dritschilo, CEO


Shuttle
Pharmaceuticals Holdings, Inc.


One
Research Court, Suite 450 Rockville, MD 20850


Email:
[  ]@shuttlepharma.com


 


If
to the Holder:


 


6.
APPLICABLE LAW AND VENUE. This Note shall be governed by and construed in accordance with the laws of the State of New York, without
giving effect to conflicts of laws thereof. Any action brought by either party against the other concerning the transactions contemplated
by this Agreement shall be brought only in the state courts of New York or in the federal courts located in New York County, in the State
of New York. Both parties and the individuals signing this Agreement agree to submit to the jurisdiction of such courts.


 


7.
WAIVER. Any waiver by the Holder of a breach of any provision of this Note shall not operate as or be construed to be a waiver of any
other breach of such provision or of any breach of any other provision of this Note. The failure of the Holder to insist upon strict
adherence to any term of this Note on one or more occasions shall not be considered a waiver or deprive that party of the right thereafter
to insist upon strict adherence to that term or any other term of this Note. Any waiver must be in writing.


 


8.
MISCELLANEOUS


 


(a)
Lawful Money; Costs of Collection. All amounts payable hereunder are payable in lawful money of the United States. Shuttle Pharma
agrees to pay all costs of collection when incurred, including reasonable attorneys’ fees and costs, whether or not a suit or action
is instituted to enforce this Note, including but not limited to court costs, appraisal fees, the cost of searching records, obtaining
title reports and title insurance and trustee’s fees, to the extent permitted by applicable law.


 




    	 



     


    

 


(b)
No Offset; Holder in Due Course. All payments under this Note made by or on behalf of Shuttle Pharma shall be made without setoff
or counterclaim and free and clear of, and without deduction or withholding for or on account of, any federal, state, or local taxes.
Shuttle Pharma waives any right of offset it now has or may hereafter have against Agent or Holder and its successors and assigns as
to this Note (but retains any such rights as to any other prior or future transaction between these parties), and agrees to make the
payments called for hereunder in accordance with the terms hereof. The holder hereof and all successors thereof shall have all the rights
of a holder in due course as provided in the Delaware Uniform Commercial Code and other laws of the State of Delaware.


 


(c)
Waivers. Shuttle Pharma and any endorsers, guarantors or sureties hereof severally waive presentment and demand for payment, notice
of intent to accelerate maturity, protest or notice of protest or nonpayment, bringing of suit and diligence in taking any action to
collect any sums owing hereunder or in proceeding against any of the rights and properties securing payment hereunder; expressly agree
that this Note, or any payment hereunder, may be extended from time to time; and consent to the acceptance of further security or the
release of any security for this Note, all without in any way affecting the liability of Shuttle Pharma and any endorsers or guarantors
hereof. No extension of time for the payment of this Note, or any installment hereof, made by agreement by the holder hereof with any
person now or hereafter liable for the payment of this Note, shall affect the original liability under this Note of Shuttle Pharma, even
if Shuttle Pharma (or any entity comprising Shuttle Pharma) is not a party to such agreement.


 


(d)
Usury Protection. The parties hereto intend to conform strictly to the applicable usury laws. In no event, regardless of any provisions
contained therein or in any other document executed or delivered in connection herewith, shall the holder hereof ever be deemed to have
contracted for or be entitled to receive, collect or apply as interest on this Note, any amount in excess of the maximum amount permitted
by applicable law (the “Maximum Rate”). In no event, whether by reason of demand for payment, prepayment, acceleration
of the maturity hereof or otherwise, shall the interest contracted for, charged or received by the holder hereunder or otherwise exceed
the Maximum Rate. If for any circumstance whatsoever interest would otherwise be payable to the holder in excess of the maximum lawful
amount, the interest payable to the holder shall be reduced automatically to the Maximum Rate and any payment received in excess of such
amount shall be applied to the outstanding principal balance of the Note.


 


(e)
Entire Agreement. This Note, the other Transaction Documents, and all other documents and instruments contemplated hereby and
thereby together constitute the entire agreement between and among the parties pertaining to the subject matter hereof. No supplement,
modification or amendment of this Note shall be binding unless executed in writing by the parties. No waiver shall be binding unless
executed in writing by the party making the waiver. No provision of this Note shall be interpreted for or against the drafting party.


 


(f)
Commercial Purpose. Shuttle Pharma agrees that no funds advanced under this Note shall be used for personal, family or household
purposes, and that all funds advanced hereunder shall be used solely for business, commercial, investment or other similar purposes.


 


(g)
Successors and Assigns. All the terms and provisions of this Note shall be binding upon and inure to the benefit of the parties
to this Note and their respective successors and assigns.


 


(h)
Assignment. Shuttle Pharma may not, voluntarily or involuntarily, directly or indirectly, by operation of law or otherwise, sell,
transfer, assign, hypothecate, pledge or in any way alienate this Note or any right or interest in this Note (each a “Transfer”)
without Holder’s prior written consent, which Holder may withhold in its sole and absolute discretion. Any consent by Holder to
any Transfer shall not constitute consent to any other Transfer. Holder may freely Transfer its interest, rights, or title in or to this
Note or the other Transaction Documents in Holder’s sole and absolute discretion.


 




    	 



     


    

 


(i)
Construction. Whenever used in this Note, the terms “including,” “include,” “includes” and
the like are not intended as terms of limitation, and, hence, shall be deemed to be followed by “without limitation.”


 


(j)
Severability. If any provision of this Note, as applied to any party or to any circumstance, shall be found by a court of competent
jurisdiction to be void, invalid or unenforceable, the same shall in no way affect any other provision of this Note, the application
of any such provision in any other circumstance, or the validity or enforceability of this Note, and any provision which is found to
be void, invalid or unenforceable shall be curtailed and limited only to the extent necessary to bring such provision within the requirements
of the law.


 


(k)
Survival of Terms. The terms and provisions of this Note shall survive the Maturity Date until full payment of all amounts due
hereunder.


 


(l)
Preferential Payment. If at any time any payment made pursuant to this Note is deemed to have been a voidable preference, fraudulent
conveyance or other similar conveyance or preferential payment under any bankruptcy, insolvency or other debtor relief or similar law,
then the obligation to make such payment shall survive any cancellation or satisfaction of this Note or return of this Note to Shuttle
Pharma and shall not be discharged or satisfied with any such payment or cancellation. Such payment shall instead remain a valid and
binding obligation enforceable in accordance with the terms of this Note and shall be immediately due and payable.


 


(m)
Relief From Stay. As an additional inducement to and material consideration for Holder agreeing to execute this this Note and the other Transaction Documents,
Shuttle Pharma agrees that in the event a Bankruptcy or Judicial Action (as hereinafter defined in this Section 8(n)) is commenced
which subjects Holder to any stay in the exercise of Holder’s rights and remedies under this Note or the other Transaction Documents,
including, but not limited to, the automatic stay imposed by Section 362 of the United States Bankruptcy Code (individually and collectively,
“Stay”), then Shuttle Pharma irrevocably consents and agrees that such Stay shall automatically be lifted and released
against Holder, and Holder shall thereafter be entitled to exercise all of its rights and remedies against Shuttle Pharma that is or
could be subject any Stay under this Note or the other Transaction Documents. Nothing contained herein shall limit or prevent Holder
from exercising all of its rights and remedies against Shuttle Pharma that is not the subject any Stay under this Note or the other Transaction
Documents. Shuttle Pharma acknowledges that it is knowingly, voluntarily, and intentionally waiving its rights to any Stay and agrees
that the benefits provided to Shuttle Pharma under the terms of this Note are valuable consideration for such waiver. As used in this
Section 8(n), the term “Bankruptcy or Judicial Action” shall mean any voluntary or involuntary case filed by
or against a Shuttle Pharma under the United States Bankruptcy Code, or any voluntary or involuntary petition in composition, readjustment,
liquidation, or dissolution, or any state and federal bankruptcy law action filed by or against a Shuttle Pharma, any action where a
Shuttle Pharma is adjudicated as bankrupt or insolvent, any action for dissolution of a Shuttle Pharma, or any action in furtherance
of any of the foregoing, or any other action, case, or proceeding that has the effect of staying (or in which a stay is being obtained
against) the enforcement by Holder of its rights and remedies under the this Note or the other Transaction Documents.


 


Except
to enforce the terms of the Transaction Documents, Shuttle Pharma shall not take any action and shall not fail to take any action which
such action or omission will or might tend to interfere with, delay, enjoin or otherwise prohibit the commencement, continuation or completion
of efforts by Holder to enforce its remedies under this Note or the other Transaction Documents, or applicable law. Without limiting
the generality of the foregoing and except to enforce the terms of the Transaction Documents, each Shuttle Pharma waives its, his, or
her rights, if any, to seek or obtain a stay, injunction or other form of order prohibiting in any way any act necessary or appropriate
for the commencement or completion of Holder’s enforcement of its remedies under the this Note or the other Transaction Documents,
or applicable law (without limiting the generality of the foregoing, such waiver extends to such rights which may exist under any statute
or rule relating to bankruptcy cases, including, without limitation, 11 U.S.C. § 105, 11 U.S.C. § 301, 11 U.S.C. § 302,
11 U.S.C. § 303, 11 U.S.C. § 304, 11 U.S.C. § 362, 11 U.S.C. § 348, 11 U.S.C. § 706, 28 U.S.C. § 157, 28
U.S.C. § 158, Federal Rule of bankruptcy Procedure (“FRBP”) 3007, FRBP 3008, FRBP 3012, FRBP 8005, FRBP 9023, FRBP 9024,
or FRBP 9029).


 




    	 



     


    

 


9.
AMENDMENT AND WAIVER OF RIGHTS. This Note may be amended and the observance of any term hereof may be waived (either generally or in
a particular instance either retroactively or prospectively) only by a written instrument executed by the Maker and the Holder.


 


10.
WAIVER OF RIGHT TO TRIAL BY JURY.


 


EACH
PARTY TO THIS NOTE HEREBY EXPRESSLY WAIVES ANY RIGHT TO TRIAL BY JURY OF ANY CLAIM, DEMAND, ACTION, OR CAUSE OF ACTION (1) ARISING UNDER
THIS NOTE, THE OTHER TRANSACTION DOCUMENTS, OR ANY OTHER INSTRUMENT, DOCUMENT, OR AGREEMENT EXECUTED OR DELIVERED IN CONNECTION THEREWITH,
OR (2) IN ANY WAY CONNECTED WITH OR RELATED OR INCIDENTAL TO THE DEALINGS OF THE PARTIES HERETO OR ANY OF THEM WITH RESPECT TO THIS NOTE
OR ANY OTHER INSTRUMENT, DOCUMENT, OR AGREEMENT EXECUTED OR DELIVERED IN CONNECTION HEREWITH, OR THE TRANSACTIONS RELATED HERETO OR THERETO,
IN EACH CASE WHETHER NOW EXISTING OR HEREAFTER ARISING, AND WHETHER SOUNDING IN CONTRACT OR TORT OR OTHERWISE; AND EACH PARTY HEREBY
AGREES AND CONSENTS THAT ANY SUCH CLAIM, DEMAND, ACTION, OR CAUSE OF ACTION SHALL BE DECIDED BY COURT TRIAL WITHOUT A JURY. THE PARTIES
HERETO HEREBY AGREE THAT THE PROVISIONS CONTAINED HEREIN HAVE BEEN FAIRLY NEGOTIATED ON AN ARM’S-LENGTH BASIS, WITH BOTH SIDES
AGREEING TO THE SAME KNOWINGLY AND BEING AFFORDED THE OPPORTUNITY TO HAVE THEIR RESPECTIVE LEGAL COUNSEL CONSENT TO THE MATTERS CONTAINED
HEREIN. ANY PARTY TO THIS NOTE MAY FILE AN ORIGINAL COUNTERPART OR A COPY OF THIS SECTION WITH ANY COURT AS WRITTEN EVIDENCE OF THE CONSENT
OF THE PARTIES HERETO TO THE WAIVER OF THEIR RIGHT TO TRIAL BY JURY AND THE AGREEMENTS CONTAINED HEREIN REGARDING THE APPLICATION OF
JUDICIAL REFERENCE IN THE EVENT OF THE INVALIDITY OF SUCH JURY TRIAL WAIVER.


 


IN
WITNESS WHEREOF, each of the Maker has caused this Note to be duly executed by a duly authorized officer as of the date set forth above.


 


	 	Shuttle
    Pharmaceuticals Holdings, Inc.
	 	 	 
	 	By:	 
	 	Name:	Dr.
    Anatoly Dritschilo
	 	Title:	Chief
    Executive Officer


 


Note
No. [           ]


 




    	 



     


    

 


EXHIBIT
B


 


FORM
OF WARRANT


 




    	14



     


    

 


NEITHER
THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION
OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED
(THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT
UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS
OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF COUNSEL TO THE TRANSFEROR
TO SUCH EFFECT, THE SUBSTANCE OF WHICH SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY. THIS SECURITY AND THE SECURITIES ISSUABLE UPON
EXERCISE OF THIS SECURITY MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT OR OTHER LOAN SECURED BY SUCH SECURITIES.


 


FORM
OF COMMON STOCK PURCHASE WARRANT


 


SHUTTLE
PHARMACEUTICALS HOLDINGS, INC.


 


	Warrant No. ___________	Issue Date: ____________2021




 


THIS
COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, [ ] or any registered
assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions
hereinafter set forth, at any time following the Issue Date (the “Initial Exercise Date”) and on or prior to
the close of business on , 20261 (the “Termination Date”) but not thereafter, to subscribe
for and purchase from Shuttle Pharmaceuticals Holdings, Inc., a Delaware corporation (the “Company”),
up to 250,000 shares of Common Stock (the “Warrant Shares”). The purchase price of one share of Common Stock
under this Warrant shall be $1.00.


 


Section
1. Definitions. For the purposes hereof, in addition to the terms defined elsewhere in this Warrant, (a) capitalized terms
not otherwise defined herein shall have the meanings set forth in the Subscription Agreement entered into by the Company and the Holder
of even day herewith and (b) the following terms shall have the following meanings:


 


“Business
Day” means any day except any Saturday, any Sunday, any day which shall be a federal legal holiday in the United States
or any day on which banking institutions in the State of New York are authorized or required by law or other governmental action to close.


 


“Common
Stock” means the shares of common stock, $0.00001 par value per share, of the Company.


 


“Common
Stock Equivalents” means any securities of the Company which would entitle the holder thereof to acquire at any time Common
Stock, including, without limitation, any debt, preferred stock, rights, options, warrants or other instrument that is at any time convertible
into or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive Common Stock.


 


“Exercise
Period” shall have the meaning as that term is defined in Section 2(a) below.


 


 






 


1
Five years from the Issue Date


 




    	1



     


    

 


“Person”
means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability
company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.


 


“Securities
Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.


 


“Trading
Day” means a day on which the New York Stock Exchange is open for business.


 


“Trading
Market” means the following markets or exchanges on which the Common Stock may be listed or quoted for trading on the date
in question: the NYSE MKT, LLC, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, or the New York
Stock Exchange.


 


“Transfer
Agent” means VStock Transfer LLC.


 


Section
2. Exercise.


 


a)
Exercise of Warrant. Exercise of the purchase rights represented by this Warrant may be made, in whole or in part, at any time
or times on or after the Initial Exercise  Date and on or before the Termination Date (the “Exercise
Period”) by delivery to the Company (or such other office or agency of the Company as it may designate by notice in writing
to the registered Holder at the address of the Holder appearing on the books of the Company) of a duly executed notice of exercise (“Notice
of Exercise”) form attached hereto as Exhibit A; and, within three (3) Trading Days of the date said Notice of Exercise
is delivered to the Company, the Company shall have received payment of the aggregate Exercise Price of the shares thereby purchased
by wire transfer or cashier’s check drawn on a United States bank. Notwithstanding anything herein to the contrary, the Holder
shall not be required to physically surrender this Warrant to the Company until the Holder has purchased all of the Warrant Shares available
hereunder and the Warrant has been exercised in full, in which case, the Holder shall surrender this Warrant to the Company for cancellation
within three (3) Trading Days of the date the final Notice of Exercise is delivered to the Company. Partial exercises of this Warrant
resulting in purchases of a portion of the total number of Warrant Shares available hereunder shall have the effect of lowering the outstanding
number of Warrant Shares purchasable hereunder in an amount equal to the applicable number of Warrant Shares purchased. The Holder and
the Company shall maintain records showing the number of Warrant Shares purchased and the date of such purchases. In the event of any
dispute or discrepancy, the records of the Company shall be controlling and determinative in the absence of manifest error.


 


b)
Exercise Price. The exercise price per share of the Common Stock under this Warrant shall be $1.00.


 




    	2



     


    

 


c)
Mechanics of Exercise.


 


i.
Delivery of Warrant Shares Upon Exercise. Certificates for shares purchased hereunder shall be transmitted by the Company’s
transfer agent (the “Transfer Agent”) to the Holder by crediting the account of the Holder’s prime broker
with the Depository Trust Company through its Deposit Withdrawal Agent Commission (“DWAC”) system if the Company
is then a participant in such system and either (A) there is an effective registration statement for its initial public offering registering
the Warrants Shares, in which case the Holder will simultaneously exercise this Warrant upon the effectiveness of such registration statement,
(B) there is a registration statement permitting the resale of the Warrant Shares by the Holder or (C) the shares are eligible for resale
without volume or manner-of-sale limitations pursuant to Rule 144, and otherwise by physical delivery of certificates to the address
specified by the Holder in the Notice of Exercise within four (4) Trading Days from the delivery to the Company of the Notice of Exercise
Form, surrender of this Warrant (if required) and payment of the aggregate Exercise Price as set forth above (the “Warrant
Share Delivery Date”). This Warrant shall be deemed to have been exercised on the date the Exercise Price is received by
the Company. The Warrant Shares shall be deemed to have been issued, and Holder or any other person so designated to be named therein
shall be deemed to have become a holder of record of such shares for all purposes, as of the date the Warrant has been exercised by payment
to the Company of the Exercise Price and all taxes required to be paid by the Holder, if any, pursuant to Section 2(d)(vi) prior to the
issuance of such shares, have been paid. .


 


ii.
Delivery of Warrants Upon Exercise. If this Warrant shall have been exercised in part, the Company shall, at the request of a
Holder and upon surrender of this Warrant certificate, at the time of delivery of the certificate or certificates representing Warrant
Shares, deliver to Holder a new Warrant evidencing the rights of Holder to purchase the unpurchased Warrant Shares called for by this
Warrant, which new Warrant shall in all other respects be identical with this Warrant.


 


iii.
Rescission Rights. If the Company fails to cause the Transfer Agent to transmit to the Holder a certificate or the certificates
representing the Warrant Shares pursuant to Section 2(d)(i) by the Warrant Share Delivery Date, then the Holder will have the right to
rescind such exercise.


 


iv.
No Fractional Shares or Scrip. No fractional shares or scrip representing fractional shares shall be issued upon the exercise
of this Warrant. As to any fraction of a share which Holder would otherwise be entitled to purchase upon such exercise, the Company shall,
at its election, either pay a cash adjustment in respect of such final fraction in an amount equal to such fraction multiplied by the
Exercise Price or round up to the next whole share.


 


v.
Charges, Taxes and Expenses. Issuance of certificates for Warrant Shares shall be made without charge to the Holder for any issue
or transfer tax or other incidental expense in respect of the issuance of such certificate, all of which taxes and expenses shall be
paid by the Company, and such certificates shall be issued in the name of the Holder or in such name or names as may be directed by the
Holder; provided, however, that in the event certificates for Warrant Shares are to be issued in a name other than the name of
the Holder, this Warrant when surrendered for exercise shall be accompanied by the assignment form (“Assignment Form”)
attached hereto as Exhibit B duly executed by the Holder and the Company may require, as a condition thereto, the payment of a sum sufficient
to reimburse it for any transfer tax incidental thereto.


 


vi.
Closing of Books. The Company will not close its shareholder books or records in any manner which prevents the timely exercise
of this Warrant, pursuant to the terms hereof.


 




    	3



     


    

 


Section
3. Certain Adjustments.


 


a)
Stock Dividends and Splits. If the Company, at any time while this Warrant is outstanding: (i) pays a stock dividend or otherwise
make a distribution or distributions on shares of its Common Stock or any other equity or equity equivalent securities payable in shares
of Common Stock (which, for avoidance of doubt, shall not include any Warrant Shares issued by the Company upon exercise of this Warrant),
(ii) subdivides outstanding shares of Common Stock into a larger number of shares, (iii) combines (including by way of reverse stock
split) outstanding shares of Common Stock into a smaller number of shares or (iv) issues by reclassification of shares of the Common
Stock any shares of capital stock of the Company, then in each case the Exercise Price shall be multiplied by a fraction of which the
numerator shall be the number of shares of Common Stock (excluding treasury shares, if any) outstanding immediately before such event
and of which the denominator shall be the number of shares of Common Stock outstanding immediately after such event and the number of
shares issuable upon exercise of this Warrant shall be proportionately adjusted such that the aggregate Exercise Price of this Warrant
shall remain unchanged. Any adjustment made pursuant to this Section 3(a) shall become effective immediately after the record date for
the determination of shareholders entitled to receive such dividend or distribution and shall become effective immediately after the
effective date in the case of a subdivision, combination or re-classification.


 


 


b)
Calculations. All calculations under this Section 4 shall be made to the nearest cent or the nearest 1/100th of a share, as the
case may be. For purposes of this Section 4, the number of shares of Common Stock deemed to be issued and outstanding as of a given date
shall be the sum of the number of shares of Common Stock (excluding treasury shares, if any) issued and outstanding.


 


c)
Notice to Holder.


 


i.
Adjustment to Exercise Price. Whenever the Exercise Price is adjusted pursuant to any provision of this Section 4, the
Company shall promptly mail to the Holder a notice setting forth the Exercise Price after such adjustment and setting forth a brief statement
of the facts requiring such adjustment.


 


ii.
Notice to Allow Exercise by Holder. If (A) the Company shall declare a dividend (or any other distribution in whatever form) on
the Common Stock, (B) the Company shall declare a special nonrecurring cash dividend on or a redemption of the Common Stock, (C) the
Company shall authorize the granting to all holders of the Common Stock rights or warrants to subscribe for or purchase any shares of
capital stock of any class or of any rights, (D) the approval of any shareholders of the Company shall be required in connection with
any reclassification of the Common Stock, any consolidation or merger to which the Company is a party, any sale or transfer of all or
substantially all of the assets of the Company, of any compulsory share exchange whereby the Common Stock is converted into other securities,
cash or property, or (E) the Company shall authorize the voluntary or involuntary dissolution, liquidation or winding up of the affairs
of the Company, then, in each case, the Company shall cause to be mailed to the Holder at its last address as it shall appear upon the
Warrant Register of the Company, at least 20 calendar days prior to the applicable record or effective date hereinafter specified, a
notice stating (x) the date on which a record is to be taken for the purpose of such dividend, distribution, redemption, rights or warrants,
or if a record is not to be taken, the date as of which the holders of the Common Stock of record to be entitled to such dividend, distributions,
redemption, rights or warrants are to be determined or (y) the date on which such reclassification, consolidation, merger, sale, transfer
or share exchange is expected to become effective or close, and the date as of which it is expected that holders of the Common Stock
of record shall be entitled to exchange their shares of the Common Stock for securities, cash or other property deliverable upon such
reclassification, consolidation, merger, sale, transfer or share exchange; provided that the failure to mail such notice or any defect
therein or in the mailing thereof shall not affect the validity of the corporate action required to be specified in such notice. The
Holder is entitled to exercise this Warrant during the period commencing on the date of such notice to the effective date of the event
triggering such notice.


 




    	4



     


    

 


Section
4. Transfer of Warrant.


 


a)
Transferability. This Warrant and all rights hereunder (including, without limitation, any registration rights) are transferable,
in whole or in part, upon surrender of this Warrant at the principal office of the Company or its designated agent, together with a written
assignment of this Warrant substantially in the form attached hereto duly executed by the Holder or its agent or attorney and funds sufficient
to pay any transfer taxes payable upon the making of such transfer. Upon such surrender and, if required, such payment, the Company shall
execute and deliver a new Warrant or Warrants in the name of the assignee or assignees, as applicable, and in the denomination or denominations
specified in such instrument of assignment, and shall issue to the assignor a new Warrant evidencing the portion of this Warrant not
so assigned, and this Warrant shall promptly be cancelled. The Warrant, if properly assigned, may be exercised by a new holder for the
purchase of Warrant Shares without having a new Warrant issued.


 


b)
Warrants. This Warrant may be divided or combined with other Warrants upon presentation hereof at the aforesaid office of the
Company, together with a written notice specifying the names and denominations in which new Warrants are to be issued, signed by the
Holder or its agent or attorney. Subject to compliance with Section 5(a), as to any transfer which may be involved in such division or
combination, the Company shall execute and deliver a new Warrant or Warrants in exchange for the Warrant or Warrants to be divided or
combined in accordance with such notice. All Warrants issued on transfers or exchanges shall be dated the Initial Exercise Date and shall
be identical with this Warrant except as to the number of Warrant Shares issuable pursuant thereto.


 


c)
Warrant Register. The Company shall register this Warrant, upon records to be maintained by the Company for that purpose (the
“Warrant Register”), in the name of the record Holder hereof from time to time. The Company may deem and treat
the registered Holder of this Warrant as the absolute owner hereof for the purpose of any exercise hereof or any distribution to the
Holder, and for all other purposes, absent actual notice to the contrary.


 


Section
5. Miscellaneous.


 


a)
No Rights as Shareholder Until Exercise. This Warrant does not entitle the Holder to any voting rights or other rights as a shareholder
of the Company prior to the exercise hereof.


 


b)
Loss, Theft, Destruction or Mutilation of Warrant. The Company covenants that upon receipt by the Company of evidence reasonably
satisfactory to it of the loss, theft, destruction or mutilation of this Warrant or any stock certificate relating to the Warrant Shares,
and in case of loss, theft or destruction, of indemnity or security reasonably satisfactory to it (which, in the case of the Warrant,
shall not include the posting of any bond), and upon surrender and cancellation of such Warrant or stock certificate, if mutilated, the
Company will make and deliver a new Warrant or stock certificate of like tenor and dated as of such cancellation, in lieu of such Warrant
or stock certificate.


 




    	5



     


    

 


c)
Saturdays, Sundays, Holidays, etc. If the last or appointed day for the taking of any action or the expiration of any right required
or granted herein shall not be a Business Day, then, such action may be taken or such right may be exercised on the next succeeding Business
Day.


 


d)
Authorized Shares.


 


The
Company covenants that, during the period the Warrant is outstanding, it will reserve from its authorized and unissued Common Stock one
hundred (100%) of the number of shares to provide for the issuance of the Warrant Shares upon the exercise of any purchase rights under
this Warrant. In case such amount of Common Stock is insufficient at any time, the Company shall call and hold a special meeting to increase
the number of authorized shares of common stock. Management of the Company shall recommend to shareholders to vote in favor of increasing
the number of authorized shares of common stock.


 


The
Company further covenants that its issuance of this Warrant shall constitute full authority to its officers who are charged with the
duty of executing stock certificates to execute and issue the necessary certificates for the Warrant Shares upon the exercise of the
purchase rights under this Warrant. The Company will take all such reasonable action as may be necessary to assure that such Warrant
Shares may be issued as provided herein without violation of any applicable law or regulation, or of any requirements of the Trading
Market upon which the Common Stock may be listed. The Company covenants that all Warrant Shares which may be issued upon the exercise
of the purchase rights represented by this Warrant will, upon exercise of the purchase rights represented by this Warrant, be duly authorized,
validly issued, fully paid and nonassessable and free from all taxes, liens and charges created by the Company in respect of the issue
thereof (other than taxes in respect of any transfer occurring contemporaneously with such issue).


 


Except
and to the extent as waived or consented to by the Holder, the Company shall not by any action, including, without limitation, amending
its amended and restated certificate of incorporation, as amended, or through any reorganization, transfer of assets, consolidation,
merger, dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance
of any of the terms of this Warrant, but will at all times in good faith assist in the carrying out of all such terms and in the taking
of all such actions as may be necessary or appropriate to protect the rights of Holder as set forth in this Warrant against impairment.
Without limiting the generality of the foregoing, the Company will (i) not increase the par value of any Warrant Shares above the amount
payable therefor upon such exercise immediately prior to such increase in par value, (ii) take all such action as may be necessary or
appropriate in order that the Company may validly and legally issue fully paid and nonassessable Warrant Shares upon the exercise of
this Warrant and (iii) use commercially reasonable efforts to obtain all such authorizations, exemptions or consents from any public
regulatory body having jurisdiction thereof, as may be, necessary to enable the Company to perform its obligations under this Warrant.


 


Before
taking any action which would result in an adjustment in the number of Warrant Shares for which this Warrant is exercisable or in the
Exercise Price, the Company shall obtain all such authorizations or exemptions thereof, or consents thereto, as may be necessary from
any public regulatory body or bodies having jurisdiction thereof.


 


e)
Jurisdiction. All questions concerning the construction, validity, enforcement and interpretation of this Warrant shall be determined
in accordance with the provisions of the laws of the State of Delaware.


 




    	6



     


    

 


f)
Restrictions. The Holder acknowledges that the Warrant Shares acquired upon the exercise of this Warrant, if not registered, will
have restrictions upon resale imposed by state and federal securities laws.


 


g)
Nonwaiver and Expenses. No course of dealing or any delay or failure to exercise any right hereunder on the part of Holder shall
operate as a waiver of such right or otherwise prejudice Holder’s rights, powers or remedies, notwithstanding the fact that all
rights hereunder terminate on the Termination Date. If the Company willfully and knowingly fails to comply with any provision of this
Warrant, which results in any material damages to the Holder, the Company shall pay to Holder such amounts as shall be sufficient to
cover any costs and expenses including, but not limited to, reasonable attorneys’ fees, including those of appellate proceedings,
incurred by Holder in collecting any amounts due pursuant hereto or in otherwise enforcing any of its rights, powers or remedies hereunder.


 


h)
Notices. Any notice, request or other document required or permitted to be given or delivered to the Holder by the Company shall
be delivered in accordance with the addresses provided by the Holder of this Warrant.


 


i)
Limitation of Liability. No provision hereof, in the absence of any affirmative action by Holder to exercise this Warrant to purchase
Warrant Shares, and no enumeration herein of the rights or privileges of Holder, shall give rise to any liability of Holder for the purchase
price of any Common Stock or as a shareholder of the Company, whether such liability is asserted by the Company or by creditors of the
Company.


 


j)
Remedies. The Holder, in addition to being entitled to exercise all rights granted by law, including recovery of damages, will
be entitled to specific performance of its rights under this Warrant. The Company agrees that monetary damages would not be adequate
compensation for any loss incurred by reason of a breach by it of the provisions of this Warrant and hereby agrees to waive and not to
assert the defense in any action for specific performance that a remedy at law would be adequate.


 


k)
Successors and Assigns. Subject to applicable securities laws, this Warrant and the rights and obligations evidenced hereby shall
inure to the benefit of and be binding upon the successors of the Company and the successors and permitted assigns of Holder. The provisions
of this Warrant are intended to be for the benefit of all Holders from time to time of this Warrant and shall be enforceable by the Holder
or holder of Warrant Shares.


 


l)
Amendment. This Warrant may be modified or amended or the provisions hereof waived with the written consent of the Company and
the Holder.


 


m)
Severability. Wherever possible, each provision of this Warrant shall be interpreted in such manner as to be effective and valid
under applicable law, but if any provision of this Warrant shall be prohibited by or invalid under applicable law, such provision shall
be ineffective to the extent of such prohibition or invalidity, without invalidating the remainder of such provisions or the remaining
provisions of this Warrant.


 


n)
Headings. The headings used in this Warrant are for the convenience of reference only and shall not, for any purpose, be deemed
a part of this Warrant.


 


[Signature
Page Follows.]


 




    	7



     


    

 


IN
WITNESS WHEREOF, the Company has caused this Warrant to be executed by its officer thereunto duly authorized as of the date first above
indicated.


 


SHUTTLE
PHARMACEUTICALS HOLDINGS, INC.


 


	By:
    	 	 
	Name:
    	Anatoly
    Dritschilo	 
	Title:	Chief
    Executive Officer	 


 




    	 



     


    

 


EXHIBIT
A


 


NOTICE
OF EXERCISE


 


TO:


 


(1)
The undersigned hereby elects to purchase__________ Warrant Shares of the Company pursuant to the terms of the attached Warrant and tenders
herewith payment of the exercise price in full, together with all applicable transfer taxes, if any.


 


(2)
Please issue a certificate or certificates representing said Warrant Shares in the name of the undersigned or in such other name as is
specified below:


 


 _____________________________


 


The
Warrant Shares shall be delivered to the following DWAC Account Number or by physical delivery of a certificate to:


 


 _____________________________


 


 _____________________________


 


 _____________________________


 


(3)
Accredited Investor. The undersigned is an “accredited investor” as defined in Regulation D promulgated under the
Securities Act of 1933, as amended.


 


[SIGNATURE
OF HOLDER]


 


	Name
    of Investing Entity:
	 _________________________________________________________________________
	 
	Signature
                                            of Authorized Signatory of Investing Entity:

                                                          

	 ___________________________________________
	 
	Name
    of Authorized Signatory:
	 
	_________________________________________________________________________
	 
	Title
    of Authorized Signatory:
	 
	 _________________________________________________________________________
	 
	Date:
	__________________________________________________________________________
	 


 




    	 



     


    

 


EXHIBIT
B


 


ASSIGNMENT
FORM


 


(To
assign the foregoing warrant, execute this form and supply required information. Do not use this form to exercise the warrant.)


 


 


FOR
VALUE RECEIVED, [___________] all of or [____________] shares of the foregoing Warrant and all rights evidenced thereby are hereby assigned
to


 


________________________________________________________whose
address is


 


 


 __________________________________________________________________.


 


 __________________________________________________________________


 


Dated:
_________________,_________


 


	 	Holder’s
    Signature:	_________________________	 
	 	 	 	 
	 	Holder’s
    Address:	_________________________	 
	 	 	 	 
	 	 	_________________________	 


 


 


Signature
Guaranteed:________________________________________


 


NOTE:
The signature to this Assignment Form must correspond with the name as it appears on the face of the Warrant, without alteration or enlargement
or any change whatsoever, and must be guaranteed by a bank or trust company. Officers of corporations and those acting in a fiduciary
or other representative capacity should file proper evidence of authority to assign the foregoing Warrant.