[Federal Register Volume 77, Number 12 (Thursday, January 19, 2012)]
[Notices]
[Pages 2728-2729]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2012-875]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES


Request for Public Comment on Nominations and Call for Additional 
Nominations to the Report on Carcinogens

AGENCY: Division of the National Toxicology Program (DNTP), National 
Institute of Environmental Health Sciences (NIEHS); National Institutes 
of Health (NIH).

ACTION: Request for Public Comment and Call for Nominations.

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SUMMARY: The NTP requests comments on several substances, mixtures, and 
exposure circumstances (collectively referred to as ``substances'') 
nominated for possible review for future editions of the Report on 
Carcinogens (RoC). The NTP also invites the nomination of additional 
substances.

DATES: The deadline for submission of public comments on the nominated 
substances is February 28, 2012; comments submitted after this date 
will be considered as time permits. There is no deadline for submission 
of new nominations.

ADDRESSES: Comments should be sent to Dr. Ruth Lunn, Director, Office 
of the RoC, DNTP, NIEHS, P.O. Box 12233, MD K2-14, Research Triangle 
Park, NC 27709; telephone (919) 316-4637; Fax: (919) 541-0144; 
<a href="/cdn-cgi/l/email-protection#acc0d9c2c2ecc2c5c9c4df82c2c5c482cbc3da"><span class="__cf_email__" data-cfemail="036f766d6d436d6a666b702d6d6a6b2d646c75">[email protected]</span></a>. Courier address: NIEHS, Room 2138, 530 Davis Drive, 
Morrisville, NC 27560.

FOR FURTHER INFORMATION CONTACT: Dr. Ruth Lunn (telephone: (919) 316-
4637 or email <a href="/cdn-cgi/l/email-protection#533f263d3d133d3a363b207d3d3a3b7d343c25"><span class="__cf_email__" data-cfemail="ef839a8181af81868a879cc1818687c1888099">[email protected]</span></a>).

SUPPLEMENTARY INFORMATION:

Background Information on the RoC

    The RoC is a congressionally mandated document that identifies and 
discusses substances that may pose a hazard to human health by virtue 
of their carcinogenicity. Substances are listed in the report as either 
known or reasonably anticipated human carcinogens. The NTP prepares the 
RoC on behalf of the Secretary of Health and Human Services following a 
formal, multi-step process for review and evaluation of selected 
substances. The evaluation process was recently revised and the final 
process is available on the RoC Web site (http://ntp.niehs.nih.gov/go/rocprocess). Information about the RoC is available on the RoC Web site 
(http://ntp.niehs.nih.gov/go/roc) or by contacting Dr. Lunn (see FOR 
FURTHER INFORMATION CONTACT).

Request for Public Comment on Nominations to the RoC

    The NTP requests public comment on the substances listed below that 
have been nominated for possible review for future editions of the RoC 
(for more information, see http://ntp.niehs.nih.gov/go/rocnom). 
Specifically, the NTP requests information on each substance for the 
following topics: (1) Data on current production, use patterns, and 
human exposure, where relevant; (2) information about published, 
ongoing, or planned studies related to evaluating carcinogenicity; (3) 
scientific issues important for assessing carcinogenicity of the 
substance; and (4) names of scientists with expertise or knowledge 
about the substance. Please include any available bibliographic 
citations for the information. The NTP will use this information for 
identifying nominated substances to propose for formal evaluation for 
the RoC.
    Persons submitting public comments are asked to include their name, 
contact information, affiliation, and sponsoring organization (if any) 
and to send them to Dr. Lunn (see ADDRESSES above). All information 
received will be posted on the RoC Web site and the submitter 
identified by name, affiliation, and sponsoring organization, if 
applicable. The deadline for submission of public comment is February 
28, 2012. Comments and information received after that date will be 
added to the public record and used by the NTP, as time permits, in 
considering whether to propose a substance for evaluation for the RoC.

Some Substances Nominated to the RoC*

    <bullet> alkenylbenzenes (selected dietary: estragole, myristicin, 
isosafrole)
    <bullet> 1-bromopropane
    <bullet> carbon black
    <bullet> cumene
    <bullet> diesel exhaust particulates
    <bullet> ethylbenzene
    <bullet> Helicobacter pylori
    <bullet> indium compounds
    <bullet> iron (excess) or iron overload
    <bullet> pentachlorophenol
    <bullet> shiftwork involving light at night
    <bullet> ortho-toluidine
    <bullet> trichloroethylene
    <bullet> uranium (depleted)
    <bullet> viruses (selected): Kaposi's sarcoma--associated 
herpesvirus, Epstein-Barr virus (EBV), human T-cell lymphotropic virus 
type 1 (HTLV-1), human immunodeficiency virus (HIV), and Merkel cell 
polyomavirus

    * Nominations to the RoC may seek to list a new substance in the 
report, reclassify the listing status of a substance already listed, or 
remove a listed substance.

Request for Additional Nominations to the RoC

    The NTP solicits and encourages the broadest participation possible 
from interested individuals or parties in nominating substances for the 
RoC. A nomination may seek to list a new substance in the report, 
reclassify the listing status of a substance already listed, or remove 
a listed substance. Nominations should contain (1) a rationale or 
reason for the RoC review and, if possible, appropriate background 
information and relevant data to support the rationale (e.g., journal 
articles, NTP Technical Reports, International Agency for Research on 
Cancer listings, exposure surveys, or release inventories) and (2) the 
nominator's name, affiliation, contact information, and

[[Page 2729]]

sponsoring organization (if any). Nominations should be sent to Dr. 
Lunn (see ADDRESSES) or submitted online via the NTP Web site (http://ntp.niehs.nih.gov/go/27911). There is no deadline for the submission of 
new nominations.

    Dated: January 9, 2012.
John R. Bucher,
Associate Director, National Toxicology Program.
[FR Doc. 2012-875 Filed 1-18-12; 8:45 am]
BILLING CODE 4140-01-P


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