Formal Recommendation 

From: National Organic Standards Board (NOSB)

To: the National Organic Program (NOP)

Date: April 26, 2019

Subject: Ammonium Glycinate

NOSB Chair: Harriet Behar

The NOSB hereby recommends to the NOP the following: 

Rulemaking Action: None

Statement of the Recommendation: 

Ammonium glycinate should not be added to the National List.

Rationale Supporting Recommendation (including consistency with OFPA and Organic 

Regulations): 

A range of natural chelating agents and synthetic substances already approved at §205.601 may 

be used to increase plant uptake or water solubility of micronutrients. This material is not 

essential to organic agriculture since alternatives already exist. 

NOSB Vote: 

Classification Motion: 

Motion to classify ammonium glycinate as synthetic

Motion by: Dave Mortenson

Seconded by: Harriet Behar

Yes: 14 No: 0 Abstain: 0 Absent: 0 Recuse: 0

Listing Motion: 

Motion to add ammonium glycinate at §205.601

Motion by: Dave Mortenson

Seconded by: Dan Seitz

Yes: 0 No: 14 Abstain: 0 Absent: 0 Recuse: 0 

Motion Failed
National Organic Standards Board

Crops Subcommittee

Petitioned Material Proposal

Ammonium Glycinate

February 5, 2019

Summary of Petition for Ammonium Glycinate:

Alpha Chelates has petitioned for the inclusion of ammonium glycinate on the National List at 205.601 

(synthetic substances allowed for use in organic crop production). This repetition follows a petition in 

2016 of Ammonium glycinate during which time the NOSB determined in its fall 2016 recommendation

that alternatives exist, including lignin sulfonate, humic acids, fulvic acids, and non-synthetic citrate. 

Also on file for this material are four petition addendums; the first addendum was submitted in 

response to a request for additional information by the Crops Subcommittee in 2016; the second 

addendum was volunteered by the petitioner in 2016; the third addendum was volunteered by the 

petitioner in 2016. An addendum to the current petition and second addendum were submitted in 

2018. At its fall 2018 board meeting, the NOSB presented a Petitioned Materials Discussion Document

to solicit stakeholder feedback. Questions were posed regarding the need expressed by farmers for the 

petitioned material and the efficacy of the petitioned chelating agent over currently approved chelating 

agents.

Ammonium glycinate is used as a chelating agent with inorganic metal micronutrients copper, iron, 

manganese, or zinc for high pH soils. Chelates are used to provide micronutrients that are readily 

available to plants in deficient soils. Ammonium glycinate is not being petitioned to be applied to crops 

alone but in its chelated forms.

During its 2016 review, the Board determined that there was insufficient information in the justification 

statement regarding the necessity of this material for organic crop production. Chelates occur naturally 

in soils, so chelates, per se, are not incompatible with a system of sustainable agriculture; however, 

overreliance on synthetic materials is not compatible with a system of sustainable agriculture. The 

Subcommittee determined that there were insufficient grounds for adding this substance to the 

National List as there are natural alternatives and one allowed synthetic already available, and as far as 

the NOSB knows, the permitted products are adequate to meet farmers’ needs.

The most recent re-petition was submitted on the premise that “the technology concerning chelating 

agents and micronutrient chelates has been significantly misunderstood by [the] NOSB”. Additionally, 

the new petition refers to the results of a field trial of wheat in high pH soil in Australia in which 

chelated micronutrients led to an increase in yield over unchelated micronutrients. A significant 

component of the original and second petitions put forth a case that the use of the term “chelating 

agent” in the regulations needs to be revisited. The petitioner requests that the NOP define which bases 

can be used to neutralize specific acids used to synthesize chelating-agent-salts. Additionally, the 

petitioner asks for “recognition that the species and strength of acid and base are needed for accurate 

and reproducible neutralization; hence the suitability for use of ‘nature identical’ acids and bases”. 

Other clarification and revision appeals are explained in the second petition.

A technical report (TR) was not requested as part of the 2016 review; however, a 2018 TR was solicited 

in response to the second application, both to review the petitioned material and to investigate the 

broader issue of nomenclature and technical errors elaborated by the petitioner. 
Summary of Review:

The Crops Subcommittee determined that in its fall 2016 recommendation that alternatives to the 

proposed substance exist as stated earlier. The most recent repetition by Alpha Chelates asserted “the 

technology concerning chelating agents and micronutrient chelates has been significantly 

misunderstood by [the] NOSB”. To address this concern a revised technical review was requested by the 

Crops Subcommittee, the revised technical review dated October 5, 2018 was provided to the Crops 

Subcommittee shortly thereafter. The Subcommittee asked that the technical review address twelve 

questions ranging from the Subcommittee’s interpretation of language related to the physical chemical 

definition of terms to the environmental fate of the proposed materials to whether or not tractable 

alternatives exist. On the latter two points, if used as proposed, the ammonium citrate has no known 

adverse environmental impacts however, the report reiterated many alternatives exist and are currently 

available for use in organic production. 

On the Subcommittee’s use and interpretation of language regarding “chelates” and “chelating agents”, 

a point the petitioner asserted the subcommittee had misapplied, the technical review concluded we 

were in fact interpreting their meaning correctly and had consistently done so in past reviews. The 

October 5, 2018 technical review provides a detailed review (top of page 4 through the middle of page 

6) of terms and definitions of those terms pertaining to “chelates”, “chelating agents” and “ligands”. 

Specifically, the technical review went on to state: “the NOP requested technical clarification of the 

terms “ligand,” “chelating agent,” and “chelate.” The petitioner claims that NOP has used “chelating 

agent” incorrectly and suggests replacing the term “chelating agent” with “ligand.” Therefore, it seems 

that, prior to the analysis of NOP’s usage of the term “chelating agent,” a discussion of the two terms 

may be helpful. A ligand has been defined as an ion or molecule that is covalently bonded to a metal

atom that can also have an independent existence. A chelating agent is a specific type of ligand and is 

characterized by its ability to form multiple bonds to the metal center from multiple attachment points 

(i.e., a polydentate ligand). Based on these definitions, it is technically correct to classify all chelating 

agents as ligands. However, in the United States (the petitioning company is Australian), it is far more 

common to refer to these polydentate ligands as “chelating agents,” rather than the more general 

“ligand.” Moreover, the term chelating agent is typically reserved for ligands that not only have the 

capacity to form multiple attachment points, but also ligands that tend towards forming these 

attachment points as a rule—a tendency that results in a specific set of properties and applications. In 

conclusion, the term ligand is not synonymous with chelating agent, with chelating agents comprising a 

specific mode of coordination while ligand refers to anything molecule or ion that coordinates to a metal 

atom.”

Category 1: Classification 

1. For CROP use: Is the substance _______ Non-synthetic or ___X____ Synthetic?

 Is the substance formulated or manufactured by a process that chemically changes a substance 

extracted from naturally occurring plant, animal, or mineral sources? [OFPA §6502(21)] If so, 

describe, using NOP 5033-1 as a guide. 

No

2. Reference to appropriate OFPA category:

Is the substance used in production, and does it contain an active synthetic ingredient in the 

following categories: [§6517(c)(1)(B)(i)]; copper and sulfur compounds; toxins derived from 

bacteria; pheromones, soaps, horticultural oils, fish emulsions, treated seed, vitamins and 
minerals; livestock parasiticides and medicines and production aids including netting, tree wraps 

and seals, insect traps, sticky barriers, row covers, and equipment cleansers; or (ii) is used in 

production and contains synthetic inert ingredients that are not classified by the Administrator 

of the Environmental Protection Agency as inerts of toxicological concern? 

No. Ammonium glycinate does not contain any of the materials listed in (A). However, as copper 

is an essential micronutrient for plant development, it may be used in concert with ammonium 

glycinate in the form of a chelate. In this form, the copper is unlikely to be reactive due to the 

multiple coordination points of the glycinate, although the water solubility of the copper (if 

used) is likely to be increased. 

When used as petitioned, ammonium glycinate would serve as an inert ingredient for the 

delivery of micronutrients. The glycinate chelated micronutrients are inert due to their multiple 

points of attachment to the micronutrient. The petitioned substance is not listed by the 

Environmental Protection Agency (EPA) as an inert of toxicological concern and is not listed in 40 

CFR 180, per (B).

Category 2: Adverse Impacts 

1. What is the potential for the substance to have detrimental chemical interactions with other 

materials used in organic farming systems? [§6518(m)(1)]

Chelates occur in nature and are used at low rates in organic farming, so there should be no 

detrimental chemical interactions with other materials used in organic farming systems. 

2. What is the toxicity and mode of action of the substance and of its breakdown products or any 

contaminants, and their persistence and areas of concentration in the environment? 

[§6518(m)(2)]

The chelated micronutrient acts to increase the bioavailability of the metal cation to ensure its 

uptake by crops. Due to the use of the petitioned as a precursor to micronutrient chelates, they 

will exist in many possible combinations that are dependent on the micronutrient in question, as 

well as the inorganic salt that is chosen as the micronutrient source. Therefore, an analysis of 

the individual ions in the environment is important. Once the water-soluble micronutrient has 

been absorbed by plant life, the glycinate anion and ammonium salt remain in the soil. 

However, both ammonium and glycinate ions are prevalent in nature, are readily metabolized 

by a variety of organisms, and therefore are not anticipated to have any toxicological impact on 

the environment. Furthermore, the need for micronutrients in trace amounts would lead to the 

introduction of minimal amounts (ppm applications) of ammonium glycinate as a micro nutrient 

chelate when used as petitioned.

3. Describe the probability of environmental contamination during manufacture, use, misuse or 

disposal of such substance? [§6518(m)(3)]

The petition states that there is minimal chance of environmental or human contamination 

during the manufacturing process as the reaction takes place inside a sealed vessel. As stated 

above, the petitioned substance is an ingredient in a finished product and is converted into a 

metal salt chelate and is therefore not subject to questions of disposal. However, ammonium 

hydroxide is used in the manufacture of the substance, and ammonium hydroxide is produced 
by the reaction of ammonia with water. Ammonia can be harmful to human health and aquatic 

life if spilled or improperly handled.

4. Discuss the effect of the substance on human health. [§6517(c)(1)(A)(i); §6517(c)(2)(A)(i); 

§6518(m)(4)].

The petition states that “in the unlikely event of contact of reaction vessel contents with human 

skin, there is a very low level of hazard as the substance is at a low concentration, is not toxic, 

and can be easily washed off with water”.

5. Discuss any effects the substance may have on biological and chemical interactions in the 

agroecosystem, including the physiological effects of the substance on soil organisms (including 

the salt index and solubility of the soil), crops and livestock. [§6518(m)(5)] 

The Subcommittee is not aware of negative effects of the petitioned material on biological and 

chemical interactions in the agroecosystem.

6. Are there any adverse impacts on biodiversity? (§205.200)

None known.

Category 3: Alternatives/Compatibility

1. Are there alternatives to using the substance? Evaluate alternative practices as well as nonsynthetic and synthetic available materials. [§6518(m)(6)]

Yes, alternatives exist. There are a range of natural chelating agents that are excreted by plants 

and microorganisms, or are produced from the decomposition of organic matter, and aid in the 

delivery of micronutrients in the soil. These compounds are broadly classified as 

phytosiderophores or phytometallophores. These compounds are wide ranging and include 

organic (carboxylic) acids and non-synthetic amino acids. However, organic or amino acids must 

first undergo a neutralization reaction with bases in the soil before they are able to acts as 

chelating agents. In basic (alkaline) soils, the application of these natural organic and amino 

acids will result in their neutralization, and the subsequent anions may act as chelating agents 

for micronutrient sources already existing in the soil.

There are a variety of synthetic substances approved in 7 CFR 205.601 that may be used in place 

of the petitioned substance as a means of increasing the water solubility of micronutrients. 

Most of these substances are acids, which would result in a pH change in the soil, converting 

insoluble hydroxide salts into more soluble micronutrient salts. The approved acids are the 

following: peracetic acid, boric acid, humic acids, and sulfurous acid. However, like the 

application of natural organic and amino acids to access natural chelating agents, the application 

of approved synthetic acids could result in the negative outcomes associated with soil 

acidification.

Lignin sulfonate, or lignosulfonate, is a synthetic chelating agent that is approved by the NOP for 

use in organic agricultural production at 7 CFR 205.601. Like ammonium glycinate, 

lignosulfonates can form chelates with cationic micronutrients, increasing their water solubility 

and bioavailability. Lignosulfonates are derived from the biopolymer lignin via the pulping 
process. Studies have shown that these chelating agents increase the uptake of both zinc and 

iron micronutrients in crops.

2. In balancing the responses to the criteria above, is the substance compatible with a system of 

sustainable agriculture? [§6518(m)(7)]

In so far as this substance is a synthetic material designed for enhancing uptake of 

micronutrients, a process which naturally occurs in soils, and for which a range of alternatives 

already exist, it is difficult to see how the substance is compatible with a system of sustainable 

agriculture. 

Classification Motion: 

Motion to classify ammonium glycinate as synthetic

Motion by: Dave Mortenson

Seconded by: Harriet Behar

Yes: 7 No:0 Abstain: 0 Absent: 1 Recuse: 0

National List Motion:

Motion to add ammonium glycinate as petitioned at §205.601

Motion by: Dave Mortenson

Seconded by: Dan Seitz

Yes: 0 No: 7 Abstain: 0 Absent: 1 Recuse: 0

Approved by Steve Ela, Subcommittee Chair to transmit to NOSB, February 9, 2019