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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MEMORANDUM 

Date: 7111/2014 

OFFICE OF CHEMICAL SAFETY 

AND POLLUTION PREVENTION 

SUBJECT: Halauxifen-Methyl Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessment for the Section 3 Registration Action on Barley, 

Wheat, and Triticale 

PC Code: 117501 

Decision No.: 470169 

Petition: 2E8086 

Risk Assessment Type: Dietary 

TXRNo.: NA 

MRIDNo.: NA 

DP Barcode: D416128 

Registration Nos.: 62719-AAE, AAG, AAN, AAR, 

AAU 

Regulatory Action: Section 3 Registration 

CaseNo.: NA 

CAS No.: 943831-98-9 

40 CFR: NA 

FROM: Douglas Dotson, Ph.D., Chemist 

Risk Assessment Branch II 

Health Effects Division 7509P) 

THROUGH: Je~fer Tyler, C~emi~ . . ~l~~ David Hrdy, Seruor Bio gist '/ttl(! f %J0~ Dietary Exposure Science Ad isory Council (DE ) 

TO: Maggie Rudick/Kable Bo Davis, PM Team 25 

Herbicide Branch 

Registration Division (7505P) 

Executive Summary 

A chronic aggregate dietary (food and drinking water) exposure assessment was conducted using 

the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database 
Halauxifen-Methyl Dietary Exposure and Risk Assessment DP Number: D416128 

(DEEM-FCID) Version 3.16. This software uses 2003-2008 food consumption data from the 

U.S. Department of Agriculture's (USDA's) National Health and Nutrition Examination Survey, 

What We Eat in America, (NHANES/WWEIA). The analysis was conducted as part of a human 

health risk assessment for the use of the new active ingredient, halauxifen-methyl. The only 

proposed new uses for this chemical are barley, wheat, and triticale. This memorandum was 

reviewed by two peer reviewers ofthe DESAC, per DESAC SOP 2012.1. 

Halauxifen-methyl has a methyl ester moiety that converts to an acid moiety upon metabolism or 

environmental degradation. The acid metabolite is referred to as XDE-729 acid. The 

toxicological effects caused by parent halauxifen-methyl and the XDE-729 acid metabolite are 

different. The parent targets the liver, while the metabolite causes kidney effects. Parent 

halauxifen-methyl causes toxicity at lower doses than the XDE-729 acid metabolite; however, 

exposure is predominantly to the metabolite. In the field trials, no residues of parent or acid 

were found in wheat or barley grain. The acid metabolite is a major degradate in drinking water. 

As the parent and metabolite have different toxicological effects, the toxicological databases for 

the two compounds were evaluated separately, and separate chronic toxicity endpoints were 

selected for them. Chronic dietary exposure assessments were performed for the two compounds 

separately. For parent halauxifen-methyl, an assessment was performed for food and drinking 

water and a separate assessment was performed for drinking water only. The assessment that 

included food was based on tolerance level residues and the assumption that 100% of all barley, 

wheat, and triticale consumed will be treated with halauxifen-methyl. For the acid metabolite, 

the assessment was based on drinking water alone because the acid metabolite is not a residue of 

concern in food, but it is a residue of concern in water. 

In all three of the chronic dietary exposure assessments that were performed, the general U.S. 

population and all population subgroups used <1% of the chronic population adjusted dose 

(cPAD). 

An acute dietary exposure assessment was not performed because acute dietary endpoints were 

not identified for the two compounds. 

Halauxifen-methyl is classified as "not likely to be carcinogenic to humans at dose levels that do 

not induce liver toxicity or Cypl a1 expression." As a result, cancer risk is not of concern for this 

chemical. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% ofthe PAD. References that discuss the acute and chronic risk assessments in 

Page 2 of 12 
Halauxifen-Methyl Dietary Exposure and Risk Assessment DP Number: D416128 

more detail are available on the EPA/pesticides web site: "Available Information on Assessing 

Exposure from Pesticides, A User's Guide," 21 Jun 2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/606l.pdf; or see SOP 99.6 (20 Aug 

1999). 

As halauxifen-methyl is a new active ingredient, this is the first dietary exposure assessment 

performed for the chemical. 

II. Residue Information 

HED has determined that the residue of concern in plant commodities for risk assessment is 

parent halauxifen-methyl only. In drinking water, the residues of concern are parent, XDE-729 

acid, X11449757, X11406790, and Degradates 1, 2, 4, 10, 11, and 14. HED decided that it was 

appropriate to perform separate dietary exposure assessments for parent halauxifen-methyl and 

the acid metabolite. For further details, see the decision memo ofthe Residues of Concern 

Knowledgebase Subcommittee (D416125, E. Holman, 5/20/2014). 

Chronic Assessment 

For both assessments, the tolerance of0.01 ppm was used as the residue input for all wheat, 

barley, and triticale commodities. 

Processing Factors 

Processing factors were not used for any commodities in the assessments. The submitted 

processing study demonstrated that residues do not concentrate in cereal grain processed 

commodities. In addition, there are no default processing factors for the wheat or barley 

processed commodities that appear in DEEM-FCID. 

Residues in Fish 

HED does not anticipate that the use ofhalauxifen-methyl on wheat, barley, and triticale will 

result in residues in fish. Tolerances are not being established for fish, and fish monitoring data 

are not available for the chemical because it has not been registered. As a result, residues in fish 

are not included in the assessment. 

III. Percent Crop Treated Information 

For the chronic assessments, the assumption was made that all commodities in DEEM-FCID, 

Version 3 .16, would be treated to a level of 1 00%. 

Page 3 of 12 
Halauxifen-Methyl Dietary Exposure and Risk Assessment DP Number: D416128 

IV. Drinking Water Data 

EFED provided estimated drinking water concentrations (EDWCs) for the proposed uses 

(D406773, R. Bohaty, 6/12/2014). EFED provided values for parent, metabolite, and the total 

toxic residues in both surface and groundwater. In all three cases (parent, metabolite, and total 

toxic residues) the groundwater values were higher than the surface water numbers. For parent, 

EFED used the PRZM-GW Model and generated a maximum groundwater value of 0.007 ppb. 

For risk assessment, the drinking water residues of concern include parent, the acid metabolite, 

and various other metabolites. For the XDE-729 acid dietary exposure assessment, all residues 

of concern were included in the EDWC, yielding a total toxic residue value of 19.5 ppb. 

V. DEEM-FCID Program and Consumption Information 

Chronic dietary exposure assessments were conducted using the DEEM-FCID, Version 3.16, 

which incorporates 2003-2008 consumption data from USDA's NHANES/WWEIA. The data 

are based on the reported consumption of more than 20,000 individuals over two nonconsecutive survey days. Foods "as consumed" (e.g., apple pie) are linked to EPA-defined food 

commodities (e.g., apples, peeled fruit- cooked; fresh or N/S; baked; or wheat flour- cooked; 

fresh or N/S, baked) using publicly available recipe translation files developed jointly by 

USDA/ARS and EPA. 

For chronic exposure assessment, consumption data are averaged for the entire U.S. population 

and within population subgroups. However, for acute exposure assessment, consumption data 

are retained as individual consumption events. Based on analysis of the 2003-2008 WWEIA 

consumption data, which took into account dietary patterns and survey respondents, HED 

concluded that it is most appropriate to report risk for the following population subgroups: the 

general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 

13-19, adults 20-49, females 13-49, and adults 50-99 years old. 

VI. Toxicological Information 

Adequate data have been submitted to characterize the toxicity ofhalauxifen-methyl and XDE729 acid for the purposes of dietary risk assessment. The database consists of studies on XDE729 acid, along with bridging and mechanistic studies on halauxifen-methyl. An acute dietary 

endpoint was not identified for either chemical. In the toxicity database, no hazard was observed 

from a single exposure. Long-term oral exposure studies were only conducted on XDE-729 

acid; however, the rat subchronic oral studies on halauxifen-methyl exhibited lower 

NOAELs/LOAELs and different target organ specificity than the subchronic studies on the acid 

metabolite. Therefore, the chronic dietary endpoint for halauxifen-methyl was based on the 

molecular initiating event for liver toxicity in the 90-day oral rat toxicity study on halauxifenmethyl to ensure that it is protective for potential effects from long-term dietary exposure to the 

parent compound. The chronic dietary endpoint for XDE-729 acid was based on effects seen in 

the rat 2-year chronic toxicity/carcinogenicity study. 

Page 4 of 12 
Halauxifen-Methyl Dietary Exposure and Risk Assessment DP Number: D416128 

Halauxifen-methyl is classified as "not likely to be carcinogenic to humans at dose levels that do 

not induce liver toxicity or Cyplal expression." As a result, cancer risk is not of concern for this 

chemical. The FQPA Safety Factor was reduced to lx for all population subgroups. The 

halauxifen-methyl doses and endpoints for dietary exposure assessment are summarized in Table 

1. The XDE-729 acid doses and endpoints for dietary exposure assessment are summarized in 

Table 2. 

Table 1. Summ~iy of ToXicological Doses ancJ Endpoints for Halauxifen-Methyl for Use in Dietary and NonOccu_l)_ational Human Health Risk Assessments 

Uncertainty/ RID, PAD, Level 

Exposure/Scenario Point of FQPA of Concern for Study and Toxicological Effec;ts Departure Safety Risk Assessment Factors ,;- ~. ,'· 

Acute Dietary (All 

-

populations, No hazard from a single exposure was identified in the available database; therefore, no risk is expected including Infants and 

Children and females from this exposure scenario. 

age 13-49) 

90-day oral toxicity in the rat (halauxifen-methyl) 

UFA= lOx Chronic RID = Increased hepatic Cyplal expression (molecular 

UFH=lOx 0.03 initiating event for liver toxicity from AhR 

Chronic Dietary (All POD=3.0 FQPASF= mglkg/day activation) was observed at 10 mglkg/day. 

Populations) mglkg/day lx cPAD =0.03 [note: study NOAEL = 10 mg/kg/day, based on 

mglkg/day liver enlargement and pathology at 52 

mglkg/day.] 

Classification: Not likely to be carcinogenic to humans at dose levels that do not induce liver toxicity 

Cancer (oral, dermal, or Cyplal expression. The cRfD is considered to be protective of potential cancer effects in the 

inhalation) absence of long-term toxicity data on halauxifen-methyl because it protects for the molecular initiating 

event for liver toxicity from AhR activation. 

Point of Departure (POD)= A data point or an estunated point that is denved from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH =potential variation in 

sensitivity among members of the human population (intraspecies). FQPA SF= FQPA Safety Factor. PAD= 

population adjusted dose (a= acute, c =chronic). RID= reference dose. MOE= margin of exposure. 

Table 2. Summary of Toxicological Doses and Endpoints for XDE-729 acid for Use in Dietary Huma~ Health Risk 

Assessments 

RID, PAD, • F •.. " ...,. 

Point of Uncertainty/ Level of 

Exposure/Scenario Departure FQPASafety Concern Study and Toxicological Effects 

Factors for Risk 

Assessment 

Acute Dietary (All 

populations, No hazard from a single exposure was identified in the available database; therefore, no risk is expected including Infants and from this exposure scenario. Children and females 

age 13-49) 

Page 5 of12 
Halauxifen-Methyl Dietary Exposure and Risk Assessment DP Number: D416128 

Table 2. Summary of Toxicological Doses and Endpoints for XDE-729 acid for Use in Dietary Human Health Risk 

Assessments . RID, PAD, 

. Uncertainty/ Level of Point of Exposure/Scenario Departure FQPASafety Concern Study and Toxicological Effects 

Factors for Risk 

.. i r.. Assessment 

Rat two-year dietary chronic toxicity/carcinogenicity 

study 

Chronic NOAEL = 101/20.3 mglkglday [M/F] 

NOAEL= RID= 0.20 LOAEL = 404/101 mglkglday [M/F] based on 

20.3 UFA= lOx mglkglday increased mortality, altered urinalysis parameters, 

Chronic Dietary (All mglkglday UFH=lOx decreased body weight, increased kidney weights, 

Populations) (female FQPA SF= lx cPAD= adrenal zone glomerulosa hypertrophy, increased 

rats) 0.20 degeneration and regeneration of renal tubules and 

kidney stones, and bladder pathology in males; in mglkglday females, hyperplasia of pelvic epithelium of the 

kidney. 

Cancer (oral, dermal, Classification: Not likely to be carcinogenic to humans. inhalation) 

Pomt of Departure (POD) = A data pomt or an estimated pomt that ts denved from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA =extrapolation from animal to human (interspecies). UFH =potential variation in 

sensitivity among members of the human population (intraspecies). FQPA SF= FQPA Safety Factor. PAD= 

population adjusted dose (a= acute, c =chronic). RID= reference dose. 

VII. Results/Discussion 

As stated above, for a chronic dietary exposure assessment, HED is concerned when dietary risk 

exceeds 100% ofthe cPAD. The DEEM-FCID analyses estimate the dietary exposure ofthe 

U.S. population and various population subgroups. The results reported in Tables 3 and 4 are for 

the general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, 

youth 13-19, females 13-49, adults 20-49, and adults 50-99 years. 

For parent halauxifen-methyl, an assessment was performed for food and drinking water and a 

separate assessment was performed for drinking water only. For the acid metabolite, the only 

assessment that was performed was for drinking water only. In all three assessments, the risk 

estimates are below HED's level of concern for the general U.S. population and all population 

subgroups. For both parent halauxifen-methyl and the XDE-729 acid metabolite, the general 

U.S. population and all population subgroups used <1% of the cP AD. 

Page 6 of 12 
Halauxifen-Methyl Dietary Exposure and Risk Assessment DP Number: D416128 

Table 3. Summary of Dietary Exposure and Risk Estimates for Parent Balauxifen-Methyl and XDE-729 

Acid 

Population Parent Halauxifen-Methyl: Parent Halauxifen-Methyl: XDE-729 Acid Metabolite: 

Subgroup Drinking Water Only Food Plus Water Drinking Water Only 

cPAD Exposure Exposure cPAD Exposure 

mglkgl Estimate %cPAD Estimate, %cPAD mglkgl Estimate %cPAD 

day mglkglday mglkglday day mglkglday 

U.S. Population 0.03 0.000000 <1 0.000017 <1 0.20 0.000408 

All infants* 0.03 0.000000 <1 0.001010 <1 0.20 0.001053 

Children 1-2 yrs 0.03 0.000000 <1 0.000040 <1 0.20 0.000589 

Children 3-5 yrs 0.03 0.000000 <1 0.000041 <1 0.20 0.000496 

Children 6-12 yrs 0.03 0.000000 <1 0.000030 <1 0.20 0.000358 

Youth 13-19 yrs 0.03 0.000000 <1 0.000018 <1 0.20 0.000298 

Adults 20-49 yrs 0.03 0.000000 <1 0.000015 <1 0.20 0.000407 

Adults 50-99 yrs 0.03 0.000000 <1 0.000012 <1 0.20 0.000403 

Females 13-49 yrs 0.03 0.000000 <1 0.000013 <1 0.20 0.000406 

*Most htghly exposed population subgroup 

VIII. Characterization of Inputs/Outputs 

The chronic assessments are unrefined. They are based on the assumption that all commodities 

will have residues at the tolerance level and that all commodities will be treated to a level of 

100%. Refinements are not needed at this time. In the event that refinements are needed in the 

future, they could be made to both the residue levels and the percentage of the crop that is 

treated. 

IX. Conclusions 

The chronic exposure estimates that were generated are conservative estimates of the actual 

dietary exposures that might occur. The aggregate (food plus drinking water) dietary risk 

estimates are below HED's level of concern for the general U.S. population and all population 

subgroups. HED is confident that the chronic assessments do not underestimate risk to the 

general U.S. population or any population subgroup. 

X. List of Attachments 

Attachment 1. Halauxifen-Methyl Chronic Residue Input File (Food and Drinking Water) 

Attachment 2. Halauxifen-Methyl Chronic Residue Input File (Drinking Water Only) 

Attachment 3. XDE-729 Acid Chronic Residue Input File (Drinking Water Only) 

Attachment 4. Results ofHalauxifen-Methyl Dietary Assessment (Food and Drinking Water) 

Attachment 5. Results ofHalauxifen-Methyl Dietary Assessment (Drinking Water Only) 

Attachment 6. Results ofXDE-729 Acid Dietary Assessment (Drinking Water Only) 

Page 7 of 12 

<1 

<1 

<1 

<I 

<1 

<1 

<1 

<1 

<I 
Halauxifen-Methyl Dietary Exposure and Risk Assessment DP Number: D416128 

Attachment 1: Halauxifen-Methyl Chronic Residue Input File (Food and Drinking Water) 

Chemical: Halauxifen-Methyl 

DEEMIFCID Program ver. 3.16, 03-08-d 

Filename: C:\U sers\ddotson\Documents\DEEM Version3 .16\HalauxifenMethyl\HalauxifenChronic.R08 

Date created/last modified: 04-24-2014118:0 I :05 

NOAEL (Chronic): 3 mglkg bw/day 

RfD(Chronic): .03 mglkg bw/day 

No Acute Dietary Endpoint 

NOAEL (Acute): 0 mglkg bw/day 

RfD(Acute): 0 mglkg bw/day 

EPA Crop 

Code Grp Commodity Name 

1500025000 15 

1500025001 15 

1500026000 15 

1500026001 15 

1500027000 15 

1500381000 15 

1500381001 15 

1500401000 15 

1500401001 15 

1500402000 15 

1500402001 15 

1500403000 15 

1500404000 15 

8601000000 86A 

8602000000 86B 

Barley, pearled barley 

Barley, pearled barley-babyfood 

Barley, flour 

Barley, flour-babyfood 

Barley, bran 

Triticale, flour 

Triticale, flour-babyfood 

Wheat, grain 

Wheat, grain-babyfood 

Wheat, flour 

Wheat, flour-babyfood 

Wheat, germ 

Wheat, bran 

Water, direct, all sources 

Water, indirect, all sources 

Def Res 

(ppm) 

0.010000 

0.010000 

0.010000 

0.010000 

0.010000 

0.010000 

0.010000 

0.010000 

0.010000 

0.010000 

0.010000 

0.010000 

0.010000 

0.000007 

0.000007 

Adj.Factors 

#1 #2 

1.000 

1. 000 

1. 000 

1.000 

1.000 

1. 000 

1. 000 

1. 000 

1.000 

1. 000 

1.000 

1.000 

1.000 

1. 000 

1. 000 

1. 000 

1. 000 

1. 000 

1.000 

1. 000 

1. 000 

1.000 

1.000 

1. 000 

1.000 

1. 000 

1. 000 

1.000 

1. 000 

1. 000 

Comment 

Attachment 2: Halauxifen-Methyl Chronic Residue Input File (Drinking Water Only) 

Chemical: Halauxifen-Methyl 

DEEM/FCID Program ver. 3.16, 03-08-d 

Filename: C:\U sers\ddotson \Documents \DEEM Version3 .16\HalauxifenMethyl\HalauxifenChronic Water0nly.R08 

Date created/last modified: 04-24-2014118:01:44 

NOAEL (Chronic): 3 mg/kg bw/day 

RfD(Chronic): .03 mglkg bw/day 

No Acute Dietary Endpoint 

NOAEL (Acute): 0 mg/kg bw/day 

RID( Acute): 0 mglkg bw/day 

EPA Crop 

Code Grp Commodity Name 

---------- ------------------------------- 8601000000 86A Water, direct, all sources 

8602000000 86B Water, indirect, all sources 

Page 8 of 12 

Def Res Adj.Factors Comment 

(ppm) #1 #2 

---------- -------

0.000007 1. 000 1. 000 

0.000007 1. 000 1. 000 
Halauxifen-Methyl Dietary Exposure and Risk Assessment DP Number: D416128 

Attachment 3: XDE-729 Acid Chronic Residue Input File (Drinking Water Only) 

Chemical: XDE-729 Acid and Metabolites 

DEEM/FCID Program ver. 3.16, 03-08-d 

Filename: C:\Users\ddotson\Documents\DEEM Version3 .16\Halaux.ifenMethyl\ XDE-729 Acid Water0nly.R08 

Date created/last modified: 04-24-2014/17:58:27 

NOAEL (Chronic): 3 mglkg bw/day 

RfD(Chronic): .03 mglkg bw/day 

No Acute Dietary Endpoint 

NOAEL (Acute): 0 mglkg bw/day 

RfD(Acute): 0 mglkg bw/day 

EPA 

Code 

Crop 

Grp Commodity Name 

8601000000 86A water, direct, all sources 

8602000000 86B Water, indirect, all sources 

Page 9 of 12 

Def Res 

(ppm) 

Adj.Factors Comment 

#1 #2 

0.019500 1.000 1.000 

0.019500 1.000 1.000 
Halauxifen-Methyl Dietary Exposure and Risk Assessment DP Number: D416128 

Attachment 4: Halauxifen-Methyl: Results of Chronic Dietary Exposure Assessment (Food and 

Drinking Water) 

DEEM-FCID Version 3.16, 03-08-d 

Food Consumption Survey: NHANES 2003-2008 2-day 

Residue file name: C:\Users\ddotson\Documents\DEEM Version3.16\HalauxifenMethyl\HalauxifenChronic.R08 

Adjustment factor #2 NOT used. 

Residue file dated: 04-24-2014118:01:05 

Analysis Date 04-24-2014/18:05:08 

Total exposure by population subgroup 

Population 

Subgroup 

Total US Population 

Hispanic 

Non-Hisp-White 

Non-Hisp-Black 

Non-Hisp-Other 

Nursing Infants 

Non-Nursing Infants 

Female 13+ PREG 

Children 1-6 

Children 7-12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13-50 

Children 1-2 

Children 3-5 

Children 6-12 

Youth 13-19 

Adults 20-49 

Adults 50-99 

Female 13-49 

Total Exposure 

mg/kg 

body wt/day 

0.000017 

0.000017 

0.000018 

0.000016 

0.000017 

0.000006 

0.001012 

0.000014 

0.000041 

0.000028 

0.000020 

0.000016 

0.000016 

0.000012 

0.000011 

0.001010 

0.000013 

0.000040 

0.000041 

0.000030 

0.000018 

0.000015 

0.000012 

0.000013 

Page 10 of 12 

Percent of 

Rfd 

0.1% 

0.1% 

0.1% 

0.1% 

0.1% 

0.0% 

0.0% 

0.0% 

0.1% 

0.1% 

0.1% 

0.1% 

0.1% 

0.0% 

0.0% 

0.0% 

0.0% 

0.1% 

0.1% 

0.1% 

0.1% 

0.0% 

0.0% 

0.0% 
Halauxifen-Methyl Dietary Exposure and Risk Assessment DP Number: D416128 

Attachment 5: Halauxifen-Methyl: Results of Chronic Dietary Exposure Assessment (Drinking 

Water Only) 

DEEM-FCID Version 3.16, 03-08-d 

Food Consumption Survey: NHANES 2003-2008 2-day 

Residue file name: C:\Users\ddotson\Documents\DEEM Version3.16\HalauxifenMethyl\ 

HalauxifenChronic WaterOnly .R08 

Adjustment factor #2 NOT used. 

Residue file dated: 04-24-2014/18:01:44 

Analysis Date 04-24-2014/18:06:10 

=============================================================================== 

Population 

Subgroup 

Total us Population 

Hispanic 

Non-Hisp-White 

Non-Hisp-Black 

Non-Hisp-Other 

Nursing Infants 

Non-Nursing Infants 

Female 13+ PREG 

Children 1-6 

Children 7-12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13-50 

Children 1-2 

Children 3-5 

Children 6-12 

Youth 13-19 

Adults 20-49 

Adults 50-99 

Female 13-49 

Total exposure by population subgroup 

Total Exposure 

mg/kg 

body wt/day 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

0.000000 

Page 11 of 12 

Percent of 

Rfd 

0.0% 

0 . 0% 

0 . 0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0 . 0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 

0.0% 
Halauxifen-Methyl Dietary Exposure and Risk Assessment DP Number: D416128 

Attachment 6: XDE-729 Acid: Results of Chronic Dietary Exposure Assessment (Drinking 

Water Only) 

DEEM-FCID Version 3.16, 03-08-d 

Food Consumption Survey: NHANES 2003-2008 2-day 

Residue file name: C:\Users\ddotson\Documents\DEEM Version3.16\HalauxifenMethyl\ 

XDE-729 Acid Water0nly.R08 

Adjustment factor #2 NOT used. 

Residue file dated: 04-24-2014/17:58:27 

Analysis Date 04-24-2014/18:08:32 

Total exposure by population subgroup 

Total Exposure 

Population 

Subgroup 

Total US Population 

Hispanic 

Non-Hisp-White 

Non-Hisp-Black 

Non-Hisp-Other 

Nursing Infants 

Non-Nursing Infants 

Female 13+ PREG 

Children 1-6 

Children 7-12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13-50 

Children 1-2 

Children 3-5 

Children 6-12 

Youth 13-19 

Adults 20-49 

Adults 50-99 

Female 13-49 

mg/kg 

body wt/day 

0.000408 

0.000390 

0.000420 

0.000337 

0. 000471 

0.000369 

0.001358 

0.000384 

0.000523 

0.000340 

0.000281 

0.000315 

0.000380 

0.000429 

0.000395 

0.001053 

0.000406 

0.000589 

0.000496 

0.000358 

0.000298 

0.000407 

0.000403 

0.000406 

Page 12 of 12 

Percent of 

Rfd 

0.2% 

0.2% 

0.2% 

0.2% 

0.2% 

0.2% 

0.7% 

0.2% 

0.3% 

0.2% 

0.1% 

0.2% 

0.2% 

0.2% 

0.2% 

0.5% 

0.2% 

0.3% 

0.2% 

0.2% 

0.1% 

0.2% 

0.2% 

0.2%