EXHIBIT 31.1



CERTIFICATION PURSUANT TO

SECTION 302 OF THE SARBANES-OXLEY ACT OF
2002



I, Ron Bentsur certify that:



(1) I have reviewed this Annual Report on
Form 10-K for the year ended December 31, 2021 of Nuvectis Pharma, Inc. (the registrant);



(2) Based on my knowledge, this report does
not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of
the circumstances under which such statements were made, not misleading with respect to the period covered by this report;



(3) Based on my knowledge, the financial
statements, and other financial information included in this report, fairly present in all material respects, the financial condition,
results of operations and cash flows of the registrant as of, and for, the periods presented in this report;



(4) The registrant’s other certifying
officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act
Rules 13a-15(e) and 15d-15(e)) for the registrant and have:



(a) designed such disclosure
controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material
information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities,
particularly during the period in which this report is being prepared;



(b) [Paragraph omitted
pursuant to Exchange Act Rules 13a-14(a) and 15d-15(a)];



(c) evaluated the effectiveness
of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the
disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and



(d) disclosed in the
report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most
recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or
is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and



(5) The registrant’s other certifying
officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s
auditors and the audit committee of registrant’s board of directors (or persons performing the equivalent functions):



(a) all significant
deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely
to adversely affect the registrant’s ability to record, process, summarize and report financial information; and



(b) any fraud, whether
or not material, that involves management or other employees who have a significant role in the registrant’s internal control over
financial reporting.



|Dated: March 23, 2022 | By: | /s/ Ron Bentsur                                       
|--------------------- | --- | ------------------------------------------------------
|                      |     | Name: Ron Bentsur                                     
|                      |     | Title: President, Chief Executive Officer and Chairman
|                      |     | Principal Executive Officer