----- Forwarded by Zachary Pekar/RTP/USEPA/US on 10/15/2012 12:26 PM

-----

From: "Zanobetti, Antonella" <azanobet@hsph.harvard.edu>

To: Zachary Pekar/RTP/USEPA/US@EPA

Date: 04/20/2012 10:20 AM Subject: RE: Request for city

- specific effect estimates for potential use in the EPA's ozone NAAQS risk

assessment



### Yes, those are the 8hr average ozone

Antonella

From: Zachary Pekar [mailto:Pekar.Zachary@epamail.epa.gov]

Sent: Thursday, April 19, 2012 3:56 PM

To: Zanobetti, Antonella

Cc: Bryan Hubbell Subject: RE: Request for city

- specific effect estimates for potential use in the EPA's ozone NAAQS risk

assessment

Antonella

- tnx!

Just to clarify

- are these 8hr average values?

zach

Zachary Pekar, MSPH, P hD

Human Health Risk Assessment Office of Air Quality Planning and Standards U.S. Environmental Protection Agency tele: (919) 541

- 3704

e

- mail: pekar.zachary@epa.gov

"Zanobetti, Antonella"

--- 04/19/2012 03:26:37 PM

--- Hi Zack, Check if this is OK

From: "Zanobetti, Antonella" < azanobet@hsph.harvard.edu > To: Zachary Pekar/RTP/USEPA/US@EPA

Date: 04/19/2012 03:26 PM Subject: RE: Request for city

- specific effect estimates for potential use in the EPA's ozone NAAQS risk assessment

Hi Zack,

Check if this is OK

Antonella

From: Zachary Pekar [ mailto:Pekar.Zachary@epamail.epa. gov ]

Sent: Thursday, April 19, 2012 2:20 PM

To: Zanobetti, Antonella

Cc: Bryan Hubbell Subject: RE: Request for city

- specific effect estimates for potential use in the EPA's ozone NAAQS risk

assessmentThanks for the support on this and I apologize if I sounded pushy

- feeling the effects of our tight time

table :) Thanks again,

zach

Zachary Pekar, MSPH, PhD

Human Health Risk Assessment Office of Air Quality Planning and Standards

U.S. Environmental Pr otection Agency tele: (919) 541

- 3704

e

- mail: pekar.zachary@epa.gov

"Zanobetti, Antonella"

--- 04/19/2012 02:15:08 PM

--- Hi Zack, I am trying to do this ASAP, just need to

finis h some other analysis first

From: "Zanobetti, Antonella" < azanobet@hsph.harvard.edu > To: Zachary Pekar/RTP/USEPA/US@EPA

Date: 04/19/2012 02:15 PM Subject: RE: Request for city

- specific effect estimates for potential use in the EPA's ozone NAAQS risk assessment

Hi Zack,

I am trying to do this ASAP, just need to finish some other analysis first

Antonella

From: Zachary Pekar [ mailto:Pekar.Zachary@epamail.epa.gov ]

Sent: Thursday, April 19, 2012 12:57 PM

To: Zanobetti, Antonella

Cc: Bryan Hubbell; Neal Fann; Pradeep Rajan Subject: RE: Request for city

- specific effect estimates for potential use in the EPA's ozone NAAQS risk

assessment

Antonella

- just following up on our request. Given how busy you are, the priority for us would be to first get the air quality summary data for the metrics used in the mortality study (i.e., 8hr average ozone by city, as described below). The city

- specific unadjusted HA effect estimates are also important, but not as critical as the exposure metric data used in the mortality study. Please let me know if and when you might be able to get us the air quality metric summary data (by city) associated with the mortality study. Thanks,

zach

Zachary Pekar, MSPH, PhD

Human Health Risk Assessment Office of Air Quality Planning and Standards

U.S. Environmental Protection Agency tele: (919) 541

- 3704

e

- mail: pekar.zachary@epa.gov

"Zanobetti, Antonella"

--- 04/12/2012 04:01:14 PM

--- Hi Zack, Thanks for the reminder!

From: "Zanobetti, A ntonella" < azanobet@hsph.harvard.edu > To: Zachary Pekar/RTP/USEPA/US@EPA

Cc: Bryan Hubbell/RTP/USEPA/US@EPA, Neal Fann/RTP/USEPA/US@EPA, Pradeep Rajan/RTP/USEPA/US@EPADate: 04/12/2012 04:01 PM

Subject: RE: Request for city

- specific effect estimates for potential use in the EPA's ozone NAAQS risk assessment

Hi Zack,

Thanks for the reminder!

I don ’ t have time today, but I will look for Mercedes city specific results.
I will also let you know about your first question.

Also: are you interested in our long term effect of ozone?

Antonella

From: Zachary Pekar [ mailto:Pekar.Zachary@epamail.epa.gov ]

Sent: Thursday, April 12, 2012 3:42 PM

To: Zanobet ti, Antonella

Cc: Bryan Hubbell; Neal Fann; Pradeep Rajan Subject: Re: Request for city

- specific effect estimates for potential use in the EPA's ozone NAAQS risk

assessment

Antonella,

I wanted to check in with you on two items:

a) in modeling short

- term exposure

- related mortality for the ozone review, as you know, we will be using the adjusted city

- specific effect estimates you provided several months ago (thanks again for those!). As part of that analysis, we were planning to look at the fraction of ris k that is associated with various increments of ambient ozone. Our goal here would be to identify the fraction of modeled risk that is associated with reduced confidence since it falls across an ambient ozone range at the lower end of the

dataset used in d riving the effect estimates used in modeling risk. Therefore, in defining those ambient ozone increments, we were hoping to use specific percentiles of the ambient ozone levels you used in your epidemiological study

- the study that provided the shrunken c ity

- specific effect estimates. Furthermore, we were hoping to implement this assessment at the city

- specific level. Consequently, would you be able to provide us with: (a) the lowest ozone level, and (b) the 5th, 10th, 25th, 50th and 75th percentile ambien t ozone levels you used in generating the shrunken city

- specific estimates and could we have these metrics by city? If it is easier to provide this city

- specific air metric data just for the 12 cities we will be including in the ozone risk assessment that would also work (the cities are: Atlanta, Boston, Cleveland, Detroit, Houston, LA, NYC, Pili, Sacramento, Baltimore, Denver, St. Louis). The study of yours I am referring to here (just to be clear) is: Zanobetti and Schwartz 2008b “ Mortality displacement

... . ”

.

We can certainly discuss this request if that would be helpful.

b) in addition, you had asked me to remind you about sending us the city

- specific (unadjusted) effect estimates for hospital admissions (respiratory effects) related to short

- term ozone exposure. The original request I sent to you for those data included the following description of the effect estimates we are looking to obtain:

As part of that risk assessment, we are considering modeling morbidity endpoints (including hospital

admissio ns for respiratory effects) associated with shorter

- term ozone exposure. We have identified your epidemiological study ("The Effect of Ozone and PM10 on Hospital Admissions for Pneumonia andChronic Obstructive Pulmonary Disease: A National Multicity Study "

- AJ of Epidemiology, Vol 183, No 5,

p. 579) as a potential source for effect estimates to use in our risk modeling. We would like to conduct modeling for individual urban study areas and therefore, were hoping that you would be able to provide us

with t he city

- specific effect estimates for ozone (2

- day cumulative lag) from your study. These would be the city

- specific effect estimates reflected in Figure 1. In addition, if you do provide the city

- specific effect estimates, would you clarify the lag struct ure reflected in those estimates (we assume they would reflect a 2 day cumulative lag) and whether those effect estimates reflect a two

- pollutant model that also accounts for PM10 or a single pollutant (ozone only) model.

Thanks for considering this requ est and as we have discussed in the past, any information we obtain would need to be able to be placed in the docket in memo form for public access (to be fully transparent regarding our data and methods). Thanks again,

zach

Zachary Pekar, MSPH, PhD

Huma n Health Risk Assessment Office of Air Quality Planning and Standards U.S. Environmental Protection Agency tele: (919) 541

- 3704

e

- mail: pekar.zachary@epa.gov

"Antonella Zanobetti"

--- 03/14/2012 02:53:30 PM

--- Hi Zach,

From: "Antonella Zanobetti" < AZANOBET@hsph.harvard.edu > To: Zachary Pekar/RTP/USEPA/US@EPA

Cc: Neal Fann/RTP/USE PA/US@EPA, Bryan Hubbell/RTP/USEPA/US@EPA, Pradeep Rajan/RTP/USEPA/US@EPA

Date: 03/14/2012 02:53 PM Subject: Re: Request for city

- specific effect estimates for potential use in the EPA's ozone NAAQS risk assessment



### Hi Zach,

I need to check if I have th ese. I will get back to you, if I don't within few days please remind me!!!

thanks

Antonella

>>> Zachary Pekar < Pekar.Zachary@epamail.epa.gov > 3/14/2012 1:54 PM >>>

Antonellal,

I had originally sent this e

- mail to Dr. Medina

- Ramon, but it bounced back, so I am forwarding the original

e

- mail to you in the hopes that you can help with this request for city

- specific effect estimates related to respiratory hospital admissions

- the o riginal e

- mail is below (if you have current contact info for Dr.

Medina

- Ramon and would rather have me contact her, just let me know). Thanks!

-----------------------

I am the lead on the ozone risk assessment being completed by EPA as part of our ongoi ng review of the National Ambient Air Quality Standard (NAAQS) for ozone. As part of that risk assessment, we are considering modeling morbidity endpoints (including hospital admissions for respiratory effects)

associated with shorter

- term ozone exposure. We have identified your epidemiological study ("The Effect of Ozone and PM10 on Hospital Admissions for Pneumonia and Chronic Obstructive Pulmonary Disease: A National Multicity Study"

- AJ of Epidemiology, Vol 183, No 5, p. 579) as a potential source for effectestimates to use in our risk modeling. We would like to conduct modeling for individual urban study areas

and therefore, were hoping that you would be able to provide us with the city

- specific effect estimates for ozone (2

- day cumulative lag) from y our study. These would be the city

- specific effect estimates reflected in Figure 1. In addition, if you do provide the city

- specific effect estimates, would you clarify the lag structure reflected in those estimates (we assume they would reflect a 2 day cu mulative lag) and whether

those effect estimates reflect a two

- pollutant model that also accounts for PM10 or a single pollutant (ozone only) model.

If we do use those effect estimates, in order to be transparent with our modeling, we would need to post them publically (probably in memo format), so I wanted to also verify that that would be ok.

As you probably would expect, our time table is tight for this risk assessment, so if you can provide us with the effect estimates, it would be great to have them in the near term.

Thanks and please let me know if you have any questions.

zach

Zachary Pekar, MSPH, PhD

Human Health Risk Assessment Office of Air Quality Planning and Standards U.S. Environmental Protection Agency tele: (919) 541

- 3704