EX-4.2





 Exhibit 4.2 

 
  

BANCO SANTANDER, S.A. 
 as
Issuer, 
 THE BANK OF NEW YORK MELLON, 

London Branch 
 as Trustee,

 and 
 THE BANK OF NEW YORK
MELLON SA/NV, 
 Luxembourg Branch 

as Subordinated Debt Securities Registrar 
  

 
 FIRST
SUPPLEMENTAL INDENTURE 
 dated as of December 3, 2020 

to 
 SUBORDINATED DEBT
SECURITIES INDENTURE 
 dated as of December 3, 2020 

 
  

 












 FIRST SUPPLEMENTAL INDENTURE (“First Supplemental Indenture”), dated as of
December 3, 2020, among BANCO SANTANDER, S.A., a sociedad anónima incorporated under the laws of The Kingdom of Spain (the “Company”), having its principal executive office located at Ciudad Grupo Santander,
Avenida de Cantabria s/n, 28660 Boadilla del Monte, Madrid, Spain, THE BANK OF NEW YORK MELLON, London Branch, a banking corporation duly organized and existing under the laws of the State of New York, as Trustee (the “Trustee”),
having its Corporate Trust Office at One Canada Square, London, E14 5AL, United Kingdom and THE BANK OF NEW YORK MELLON SA/NV, Luxembourg Branch, a société anonyme/naamloze vennootschap, incorporated under the laws of
Belgium, as Subordinated Debt Securities Registrar (the “Subordinated Debt Securities Registrar”), having its principal office at 2-4 Rue Eugène Ruppert, L-2453 Luxembourg, Luxembourg. 
 WITNESSETH 

WHEREAS, the Company and the Trustee have executed and delivered a Subordinated Debt Securities Indenture dated as of December 3, 2020
(the “Base Indenture”, and together with this First Supplemental Indenture, the “Subordinated Notes Indenture”) to provide for the issuance of the Company’s subordinated debt securities (the
“Subordinated Debt Securities”), including the Subordinated Notes (as defined below). 
 WHEREAS, Section 9.01(d) of
the Base Indenture permits the Company and the Trustee to change or eliminate any provisions of the Base Indenture without the consent of Holders, subject to certain conditions; 

WHEREAS, Section 9.01(f) of the Base Indenture permits the Company and the Trustee to enter into a supplemental indenture to establish
the forms or terms of Subordinated Debt Securities of any series as permitted under Sections 2.01 and 3.01 of the Base Indenture without the consent of Holders; 

WHEREAS, there are no debt securities Outstanding of any series created prior to the execution of this First Supplemental Indenture that are
entitled to the benefit of the provisions set forth herein or that would be adversely affected by such provisions; 
 WHEREAS, the Executive
Committee of the Company have authorized the entry into this First Supplemental Indenture and the establishment of the Subordinated Notes (as defined below), as required by Section 9.01 of the Base Indenture; 

WHEREAS, the parties hereto desire to establish a series of Subordinated Debt Securities to be known as the Series 100 2.749% Tier 2
Subordinated Fixed Rate Notes due 2030 (the “Subordinated Notes”) pursuant to Sections 2.01 and 3.01 of the Base Indenture. The Subordinated Notes may be issued from time to time, and any Subordinated Notes issued as part of the
series created herein will constitute a single series of Subordinated Debt Securities under the Subordinated Notes Indenture and shall be included in the definition of “Subordinated Notes” where the context requires; 

  
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 WHEREAS, the Company has requested and hereby requests that the Trustee execute and deliver
this First Supplemental Indenture and the Company has provided the Trustee with an Executive Committee Resolution authorizing the execution of this First Supplemental Indenture; 

WHEREAS, all actions required by the Company to be taken in order to make this First Supplemental Indenture a valid, binding and enforceable
instrument in accordance with its terms, have been taken and performed, and the execution and delivery of this First Supplemental Indenture has been duly authorized in all respects; and 

WHEREAS, where indicated, this First Supplemental Indenture shall amend and supplement the Base Indenture; and to the extent that the terms of
the Base Indenture are inconsistent with such provisions of this First Supplemental Indenture, the terms of this First Supplemental Indenture shall govern. 

NOW, THEREFORE, the Company and the Trustee mutually covenant and agree as follows: 

ARTICLE 1 
 DEFINITIONS 

Section 1.01.    Definition of Terms. For all purposes of this First Supplemental Indenture: 

(a)    a term defined anywhere in this First Supplemental Indenture has the same meaning throughout; 

(b)    capitalized terms used herein but not otherwise defined shall have the meanings assigned to them in the Base
Indenture; 
 (c)    the singular includes the plural and vice versa; 

(d)    headings are for convenience of reference only and do not affect interpretation; and 

(e)    for the purposes of this First Supplemental Indenture and the Base Indenture, the term “series” shall
mean a series of the Subordinated Debt Securities. 
 ARTICLE 2 

FORM OF SUBORDINATED NOTES 

Section 2.01.    Terms of the Subordinated Notes. The following terms relating to the Subordinated Notes are
hereby established pursuant to Section 3.01 of the Base Indenture: 
 (a)    The Subordinated Notes shall be
designated as: the Series 100 2.749% Tier 2 Subordinated Fixed Rate Notes due 2030; 

  
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 (b)     The price at which the Subordinated Notes shall be issued is
100.000% of the principal amount thereof; 
 (c)     The aggregate principal amount of the Subordinated Notes that may
be authenticated and delivered under the Subordinated Notes Indenture shall not exceed $1,500,000,000, except as otherwise provided in the Subordinated Notes Indenture, including Section 2.01(t) hereof; 

(d)     Principal on the Subordinated Notes shall be payable on December 3, 2030 (the “Maturity
Date”); 
 (e)     The Subordinated Notes shall be issued in global registered form on December 3, 2020
and shall bear interest from and including December 3, 2020 payable semi-annually in arrears on June 3 and December 3 (each, a “Interest Payment Date”), commencing June 3, 2021. The Subordinated Notes shall bear
an annual interest rate of 2.749%; 
 Interest on the Subordinated Notes will be calculated on the basis of a
360-day year divided into twelve months of 30 days each and, in the case of an incomplete month, the actual number of days elapsed in such month. The Regular Record Dates for the Subordinated Notes will be 15
calendar days immediately preceding the relevant Interest Payment Date, whether or not a Business Day; 
 (f)     No
premium, upon redemption or otherwise, shall be payable by the Company on the Subordinated Notes; 
 (g)     Principal
of and any interest on the Subordinated Notes shall be paid to the Holder through The Bank of New York Mellon, as paying agent of the Company having offices in London, United Kingdom and the Borough of Manhattan, The City of New York; 

(h)     The Subordinated Notes shall not be redeemable except as provided in Article 11 of the Base Indenture, as amended
and supplemented by this First Supplemental Indenture; 
 (i)     The Company shall have no obligation to redeem or
purchase the Subordinated Notes pursuant to any sinking fund or analogous provision; 
 (j)     The Subordinated Notes
shall be issued only in minimum denominations of $200,000 and integral multiples of $200,000 in excess thereof; 
 (k)
    The principal amount of the Subordinated Notes shall be payable upon the declaration of acceleration thereof pursuant to Section 5.02 of the Base Indenture; 

  
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 (l)     Additional Amounts in respect of the Subordinated Notes shall be
payable as set forth in the Base Indenture, as amended and supplemented by this First Supplemental Indenture; 
 (m)
    The Subordinated Notes shall be denominated in, and payments thereon shall be made in, U.S. Dollars only; 
 (n)
    The payment of principal of or interest, if any, on the Subordinated Notes shall be payable only in the coin or currency in which the Subordinated Notes are denominated; 

(o)     The Subordinated Notes will be issued in the form of one or more global securities in registered form, without
coupons attached, and initially registered in the name of Cede & Co., as nominee of The Depository Trust Company, the Depositary; 

(p)     The Subordinated Notes will not be initially issued in definitive form; 

(q)     The Events of Default on the Subordinated Notes are as provided for in the Base Indenture, as amended and
supplemented by this First Supplemental Indenture; 
 (r)     The Company agrees with respect to the Subordinated Notes
and each Holder of the Subordinated Notes, by his or her acquisition of a Subordinated Note will be deemed to have agreed to the subordination described in Sections 12.01 and 12.02 of the Base Indenture, as amended and supplemented by this First
Supplemental Indenture. Each such Holder will be deemed to have irrevocably waived his or her rights of priority which would otherwise be accorded to him or her under the laws of Spain, to the extent necessary to effectuate the subordination
provisions of the Subordinated Notes. In addition, each Holder of the Subordinated Notes by his or her acquisition of a Subordinated Note authorizes and directs the Trustee on his or her behalf to take such action as may be necessary or appropriate
to effectuate the subordination of the Subordinated Notes as provided in the Base Indenture, as amended and supplemented by this First Supplemental Indenture, and appoints the Trustee as his or her attorney-in-fact for any and all such purposes; 
 (s)     The form of the
Subordinated Notes to be issued on the date hereof shall be substantially in the form of Exhibit A hereto; 
 (t)
    The Company may issue additional Subordinated Notes (“Additional Subordinated Notes”) after the date hereof having the same ranking and same interest rate, maturity date, redemption terms and other terms,
except for the price to the public, original interest accrual date, issue date and first Interest Payment Date, as the Subordinated Notes; provided, however, that such Additional Subordinated Notes will not have the same CUSIP, ISIN or other
identifying number as the outstanding Subordinated Notes unless the Additional Subordinated Notes are fungible with the Subordinated Notes for U.S. federal income tax purposes. Any such Additional Subordinated Notes, together with the Subordinated
Notes, will constitute a single series of securities under the Subordinated Notes Indenture; 

  
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 (u)     There is no Calculation Agent for the Subordinated Notes; 

(v)     The Company appoints The Bank of New York Mellon SA/NV, Luxembourg Branch as the Subordinated Debt Securities
Registrar for the Subordinated Notes pursuant to Section 3.05 of the Base Indenture; 
 (w)     If a Capital
Disqualification Event, a TLAC/MREL Disqualification Event or a tax event that would entitle the Company to redeem the Subordinated Notes as set forth in Section 11.08 of the Base Indenture occurs and is continuing, the Company may substitute
all (but not some) of the Subordinated Notes or modify the terms of all (but not some) of the Subordinated Notes as provided for in Section 8.04 of the Base Indenture, as amended and supplemented by this First Supplemental Indenture; 

(x)     Subject to applicable law, neither any Holder or beneficial owner of the Subordinated Notes nor the Trustee acting
on behalf of the Holders of the Subordinated Notes may exercise, claim or plead any right of set-off, compensation or retention in respect of any amount owed to it by the Company in respect of, or arising
under, or in connection with, the Subordinated Notes as provided for in Section 12.04 of the Base Indenture, as amended and supplemented by this First Supplemental Indenture; 

(y)     Each Holder of the Subordinated Notes acknowledges, accepts, consents to and agrees to be bound by effect of the
exercise of the Bail-in Power by the Relevant Resolution Authority as provided for in Article 13 of the Base Indenture, as amended and supplemented by this First Supplemental Indenture; and 

(z)     The Bank of New York Mellon SA/NV, Luxembourg Branch, as the Subordinated Debt Securities Registrar for the
Subordinated Notes acknowledges, accepts, consents to and agrees to be bound by effect of the exercise of the Bail-in Power by the Relevant Resolution Authority as provided for in Article 13 of the Base
Indenture, as amended and supplemented by this First Supplemental Indenture. 
 ARTICLE 3 

ADDITIONAL TERMS APPLICABLE TO THE SUBORDINATED NOTES 

Section 3.01.    Addition of Definitions. With respect to the Subordinated Notes only, Section 1.01 of
the Base Indenture is amended to include the following definitions (which shall be deemed to arise in Section 1.01 in their proper alphabetical order): 

“Early Redemption Amount (TLAC/MREL Disqualification Event)” has the meaning set forth in Section 11.10.

 “EU Banking Reforms” means the CRD V Directive, BRRD II, CRR II and the SRM Regulation II. 

  
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 “Issue Date” means December 3, 2020, being the date of
the initial issue of the Subordinated Notes. 
 “Maturity Date” means December 3, 2030. 

A “TLAC/MREL Disqualification Event” shall have occurred at any time that all or part of the outstanding
nominal amount of the Subordinated Notes does not fully qualify as TLAC/MREL Eligible Instruments of the Company and/or the Group, except where such non-qualification (i) is due solely to the remaining
maturity of the Subordinated Notes being less than any period prescribed for TLAC/MREL Eligible Instruments by the Applicable Banking Regulations as at the Issue Date or (ii) is as a result of the Subordinated Notes being bought back by or on
behalf of the Company or a buy back of the Subordinated Notes which is funded by or on behalf of the Company. 
 A TLAC/MREL
Disqualification Event shall, without limitation, be deemed to include where such non-qualification arises as a result of (a) any legislation which gives effect to the EU Banking Reforms in the Kingdom of
Spain differing in any respect from the EU Banking Reforms (including if the EU Banking Reforms are not implemented in full in the Kingdom of Spain), or (b) the official interpretation or application of the EU Banking Reforms as implemented in
the Kingdom of Spain (including any interpretation or pronouncement by any relevant court, tribunal or authority) differing in any respect from the manner in which the EU Banking Reforms have been reflected herein. 

“TLAC/MREL Eligible Instrument” means an instrument that complies with the TLAC/MREL Requirements. 

“TLAC/MREL Requirements” means the total loss-absorbing capacity requirements and/or minimum requirement for
own funds and eligible liabilities applicable to the Company and/or the Group under the Applicable Banking Regulations. 
 Section.
3.02.    Deletion of Definitions. With respect to the Subordinated Notes only, the following definitions shall be deleted in their entirety in Section 1.01 of the Base Indenture: 

“Early Redemption Amount (Call)” has the meaning set forth in Section 11.10. 

“Foreign Currency” means the euro or any currency issued by the government of any country (or a group of
countries or participating member states) other than the United States which as at the time of payment is legal tender for the payment of public and private debts. 

“Foreign Government Securities” means with respect to Subordinated Debt Securities of any series that are
denominated in a Foreign Currency, non-callable (i) direct obligations of the participating member state or government that issued such Foreign Currency for the payment of which obligations its full faith
and 

  
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credit is pledged or (ii) obligations of a Person controlled or supervised by and acting as an agency or instrumentality of such participating member state or government, the payment of
which obligations is unconditionally guaranteed as a full faith and credit obligation of such participating member state or government. For the avoidance of doubt, for all purposes hereof, euro shall be deemed to have been issued by each
participating member state from time to time. 
 “U.S. Government Obligations” means securities that are non-callable and nonredeemable at the option of the issuer and that are (i) direct obligations of the United States for which its full faith and credit are pledged and/or (ii) obligations of a Person
controlled or supervised by and acting as an agency or instrumentality of the United States, the payment of which is unconditionally guaranteed as a full faith and credit obligation of the United States, and shall also include a depository receipt
issued by a bank (as defined in Section 3(a)(2) of the Securities Act of 1933, as amended), which may include the Trustee, as custodian with respect to any such U.S. Government Obligation or a specific payment of principal of or interest on any
such U.S. Government Obligation held by such custodian for the account of the holder of such depository receipt, provided that (except as required by law) such custodian is not authorized to make any deduction from the amount payable to the holder
of such depository receipt from any amount received by the custodian in respect of the U.S. Government Obligation or the specific payment of principal of or interest on or other amount with respect to the U.S. Government Obligation evidenced by such
depository receipt. 
 Section 3.03.    Replacement of Definitions. With respect to the Subordinated
Notes only, Section 1.01 of the Base Indenture is amended to replace in their entirety the following definitions: 

“Additional Tier 1 Instrument” means any contractually subordinated obligation (créditos
subordinados) of the Company according to Article 281.1.2o of the Spanish Insolvency Law, ranking as an additional tier 1 instrument (instrumentos de capital adicional de nivel 1) under Additional Provision 14.3o(c) of Law
11/2015. 
 “Business Day” means any day, other than Saturday or Sunday, that is not a Legal Holiday
nor a day on which banking institutions are authorized or required by law, regulation or executive order to close in the City of New York or London nor a day when the Trans-European Automated Real-time Gross Settlement Express Transfer system (the
TARGET2 System), or any successor thereto, is closed for business. 
 “Qualifying Notes” means, with
respect to the Subordinated Notes, at any time, any securities issued directly by the Company that have terms not otherwise materially less favorable to the Holders of the Subordinated Notes than the terms of the Subordinated Notes, provided that
the Company shall have delivered a certificate signed by two directors of the Company to that effect to the Trustee not less than five Business Days prior to (x) in the case of a substitution of the Subordinated Notes pursuant to
Section 8.04, the issue date of the relevant 

  
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securities or (y) in the case of a variation of the Subordinated Notes pursuant to Section 8.04, the date such variation becomes effective, provided that such securities shall: 

 

	 	(i)	 contain terms which comply with the then current requirements for TLAC/MREL Eligible Instruments as embodied in
the Applicable Banking Regulations and with the then current requirements for their inclusion in the Tier 2 Capital of the Company; 


  

	 	(ii)	 carry the same rate of interest as the Subordinated Notes prior to the relevant substitution or variation
pursuant to Section 8.04; 


  

	 	(iii)	 have the same denomination and aggregate outstanding principal amount as the Subordinated Notes prior to the
relevant substitution or variation pursuant to Section 8.04; 


  

	 	(iv)	 have the same date of maturity and the same dates for payment of interest as the Subordinated Notes prior to
the relevant substitution or variation pursuant to Section 8.04; 


  

	 	(v)	 have at least the same ranking as the Subordinated Notes; 



 

	 	(vi)	 not, immediately following such substitution or variation, be subject to a Capital Disqualification Event, a
TLAC/MREL Disqualification Event and/or a tax event that would entitle the Company to redeem the debt securities as set forth under Section 11.08; and 


  

	 	(vii)	 be listed or admitted to trading on any stock exchange as selected by the Company, if the Subordinated Notes
were listed or admitted to trading on a stock exchange immediately prior to the relevant substitution or variation pursuant to Section 8.04. 



“Redemption Price”, when used with respect to any Subordinated Note to be redeemed, means the price at
which it is to be redeemed pursuant to this Subordinated Notes Indenture, which shall include the Early Redemption Amount (Tax), Early Redemption Amount (Capital Disqualification Event) or Early Redemption Amount (TLAC/MREL Disqualification Event),
as applicable. 
 “Relevant Resolution Authority” means the Spanish Fund for the Orderly
Restructuring of Banks, the Bank of Spain, the European Single Resolution Board, as the case may be, according to Law 11/2015, and any other entity with the authority to exercise the Bail-in Power or any other
resolution power from time to time. 
 “Senior Non Preferred Liabilities” means any unsubordinated and
unsecured senior non preferred obligations (créditos ordinarios no preferentes) of the Company under Additional Provision 14.2o of Law 11/2015 and any other obligations which, by law and/or by their terms, and to the extent
permitted by Spanish law, rank pari passu with the Senior Non Preferred Debt Liabilities. 

  
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 “Senior Subordinated Liabilities” means any contractually
subordinated obligation (créditos subordinados) of the Company according to Article 281.1.2o of the Spanish Insolvency Law, ranking as subordinated debt which is not an Additional Tier 1 Instrument or a Tier 2 Instrument(deuda
subordinada que no sea capital adicional de nivel 1 o 2) under Additional Provision 14.3o(a) of Law 11/2015. 

“Tier 2 Instrument” means any contractually subordinated obligation (créditos subordinados) of
the Company according to Article 281.1.2o of the Spanish Insolvency Law, ranking as a tier 2 instrument (instrumentos de capital de nivel 2) under Additional Provision 14.3o(b) of Law 11/2015. 

Section 3.04.    [Reserved]. 

Section 3.05.    Collection of Indebtedness and Suits for Enforcement by the Trustee. With respect to the
Subordinated Notes only, Section 5.03 of the Base Indenture is amended in part to add the following sentences at the end of the section: 

No remedy against the Company other than as referred to in this Article 5 shall be available to the Holders, whether for the
recovery of amounts owing to the Holders in respect of the Subordinated Notes or under this Subordinated Notes Indenture or in respect of any breach by the Company of any of its other obligations under or in respect of the Subordinated Notes or
under this Subordinated Notes Indenture, except that the Holders shall have such rights and powers as they are required to have under the Trust Indenture Act. 

Section 3.06.    Deletion of Satisfaction and Discharge Provisions. With respect to the Subordinated Notes
only, Article 4 of the Base Indenture is deleted in its entirety. 
 Section 3.07.    Deletion of Provisions
with Respect to Selection by the Trustee of Subordinated Notes to Be Redeemed. With respect to the Subordinated Notes only, the first paragraph of Section 11.03 of the Base Indenture is deleted in its entirety. 

Section 3.08.    Replacement of Provisions with Respect to Optional Redemption. With respect to the
Subordinated Notes only, Section 11.10 of the Base Indenture is hereby replaced with the following. 
 Optional
Redemption For TLAC/MREL Disqualification Event. Unless otherwise provided as contemplated by Section 3.01 with respect to the Subordinated Notes if, in relation to the Subordinated Notes, a TLAC/MREL Disqualification
Event has occurred and is continuing, then the Company may, at its option and having given not less than 15 nor more than 60 days’ notice to the Holders of the Subordinated Notes in accordance with Section 11.04 above (which notice shall
be irrevocable and shall specify the date for redemption) and a concurrent copy thereof to the Trustee, elect to redeem in whole but not in part the Outstanding Subordinated Notes at their principal amount, together with any accrued and unpaid
interest thereon to (but excluding) the date fixed for redemption (“Early Redemption Amount (TLAC/MREL Disqualification Event)”). 

  
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 Redemption on the basis of a TLAC/MREL Disqualification Event is subject to
is subject to the prior consent of the Regulator if and as required under Applicable Banking Regulations and may only take place in accordance with Applicable Banking Regulations in force at the relevant time. 

Section 3.09.    Payment. Notwithstanding Section 3.07 of the Base Indenture, payments of interest, if
any, and any Additional Amounts on the Subordinated Notes may be made by wire transfer of immediately available funds. 

Section 3.10.    Replacement of Provisions with Respect to Events of Default. With respect to the Subordinated
Notes only, Section 5.01(ii) of the Base Indenture is hereby replaced with the following: 
 Winding up: any
order is made by any competent court or resolution passed for the winding up, dissolution or liquidation of the Company (except in any such case for the purpose of reconstruction or amalgamation or a merger or
spin-off or any other structural modification (modificación estructural) which has been previously approved by the Holders of at least a majority of the outstanding principal amount of the
Subordinated Notes or a merger with, or spin-off or other structural modification into, another institution in this case even without being approved by Holders of the Subordinated Notes, provided that such
merger, spin-off or other structural modification is carried out in compliance with the requirements set forth in Section 8.01 of the Base Indenture). 

Section 3.11.    Replacement of Provisions with Respect to Substitution and Variation. With respect to the
Subordinated Notes only, the first (1st) paragraph of Section 8.04 of the Base Indenture is hereby replaced with the following: 

Substitution and Variation. If a Capital Disqualification Event, a TLAC/MREL Disqualification Event or an event that
would entitle the Company to redeem the Subordinated Notes as set forth in Section 11.08 occurs and is continuing, the Company may substitute all (but not some) of the Subordinated Notes or modify the terms of all (but not some) of the
Subordinated Notes, without any requirement for the consent or approval of the Holders of the Subordinated Notes, so that they are substituted for, or varied to, become, or remain, Qualifying Notes, subject to having given not less than 15 nor more
than 60 days’ notice to the Holders of the Subordinated Notes in accordance with Section 1.06 and to the Trustee (which notice shall be irrevocable and shall specify the date for substitution or, as applicable, variation), and subject to
obtaining Regulator consent, if required. 

  
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 Section 3.12.    Replacement of Provisions with Respect to
Additional Amounts. With respect to the Subordinated Notes only, the sixth (6th) paragraph of Section 10.04 of the Base Indenture is hereby replaced with the following: 

As used in this Section 10.04, the term “Redemption Amount” means, as appropriate, the Maturity Redemption
Amount, Early Redemption Amount (Tax), Early Redemption Amount (TLAC/MREL Disqualification Event), Early Redemption Amount (Capital Disqualification Event) and Early Termination Amount or such other amount in the nature of a redemption amount as may
be specified in, or determined in accordance with the Section 3.01. 
 Section 3.13.    Replacement of
Provisions with Respect to Notice of Redemption. With respect to the Subordinated Notes only, item “(d)” of the second (2nd) paragraph of Section 11.04 of the Base Indenture is
hereby replaced with the following: 
 (d) if fewer than all the Outstanding Subordinated Notes are to be redeemed, the
principal amount of the Subordinated Notes to be redeemed, (except in the case of a redemption pursuant to Section 11.08, 11.09 or 11.10, which must be a redemption in full), 

Section 3.14.    Replacement of Provisions with Respect to Subordination. With respect to the Subordinated
Notes only, Section 12.01 of the Base Indenture is hereby replaced with the following: 
 Subordinated Notes
Subordinate to Claims of Senior Creditors. The Company, for itself, its successors and assigns, covenants and agrees, and each Holder of the Subordinated Notes by his acceptance thereof, likewise covenants and agrees, that the payment
obligations of the Company under the Subordinated Notes on account of principal constitute direct, unconditional, unsecured and subordinated obligations (créditos subordinados) of the Company according to Article
281.1.2o of the Spanish Insolvency Law and, in accordance with Additional Provision 14.3o of Law 11/2015, but subject to any other ranking that may apply as a result of any mandatory provision of law (or otherwise), upon the insolvency of
the Company rank for so long as the obligations of the Company in respect of the Subordinated Notes constitute Tier 2 Instruments: 
  

	 	(i)	 pari passu among themselves and with (a) all other claims for principal in respect of Tier 2
Instruments which are not subject to any other ranking that may apply as a result of any mandatory provision of law (or otherwise), and (b) any other subordinated obligations (créditos subordinados) which by law and/or by
their terms, to the extent permitted by Spanish law, rank pari passu with the Company’s obligations under the Subordinated Notes; 


  

	 	(ii)	 junior to (a) any unsubordinated obligations (créditos ordinarios) of the Company
(including any Senior Non Preferred Liabilities), (b) any claim for principal in respect of Senior Subordinated Liabilities which are not subject to any other ranking that may apply as a result of any mandatory provision of law (or otherwise) and
(c) any other subordinated obligations (créditos subordinados) which by law and/or by their terms, to the extent permitted by Spanish law, rank senior to the Company’s obligations under the Subordinated Notes; and




  
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	 	(iii)	 senior to (a) any claims for principal in respect of Additional Tier 1 Instruments of the Company, and
(b) any other subordinated obligations (créditos subordinados) of the Company which by law and/or by their terms, to the extent permitted by Spanish law, rank junior to the obligations of the Company under the Subordinated
Notes. 


 Claims of Holders of Subordinated Notes in respect of interest accrued but unpaid as of the
commencement of any insolvency procedure in respect of the Company shall constitute subordinated claims (créditos subordinados) against the Company ranking in accordance with the provisions of Article 281.1.3o of the Spanish Insolvency
Law and no further interest shall accrue from the date of the declaration of insolvency of the Company. 
 The provisions
of this Article 12 shall apply only to rights or claims payable under the Subordinated Notes and nothing herein shall affect or prejudice the payment of the costs, charges, expenses, liabilities, indemnity or remuneration of the Trustee, the first
lien rights of the Trustee under Section 6.08 hereof, or the rights and remedies of the Trustee in respect thereof. 

The Company agrees with respect to the Subordinated Notes and each Holder of Subordinated Notes, by his or her acquisition of a
Subordinated Note will be deemed to have agreed to the subordination as described in this Section 12.01. Each such Holder will be deemed to have irrevocably waived his or her rights of priority which would otherwise be accorded to him or her
under the laws of Spain, to the extent necessary to effectuate the subordination provisions of the Subordinated Note. In addition, each Holder of Subordinated Notes by his or her acquisition of such Subordinated Notes authorizes and directs the
Trustee on his or her behalf to take such action as may be necessary or appropriate to effectuate the subordination of the such Subordinated Notes as provided in this Subordinated Notes Indenture and appoints the Trustee as his or her attorney-in-fact for any and all such purposes. 
 ARTICLE 4 

MISCELLANEOUS 

Section 4.01.    Effect Of Supplemental Indenture. Upon the execution and delivery of this First Supplemental
Indenture by each of the Company and the Trustee, the Base Indenture shall be supplemented in accordance herewith, and this First Supplemental Indenture shall form a part of the Base Indenture for all purposes in respect of the Subordinated Notes or
otherwise as applicable. 
 Section 4.02.    Confirmation Of Indenture. The Base Indenture, as amended and
supplemented by this First Supplemental Indenture with respect to the Subordinated Notes or otherwise as applicable, is in all respects ratified and confirmed, and the Base 

  
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Indenture, this First Supplemental Indenture and all indentures supplemental thereto shall, in respect of the Subordinated Notes or otherwise as applicable, be read, taken and construed as one
and the same instrument. This First Supplemental Indenture constitutes an integral part of the Subordinated Notes Indenture and, where applicable, with respect to the Subordinated Notes. In the event of a conflict between the terms and conditions of
the Base Indenture and the terms and conditions of this First Supplemental Indenture, the terms and conditions of this First Supplemental Indenture shall prevail where applicable. 

Section 4.03.    Concerning The Trustee. The Trustee does not make any representations as to the validity,
sufficiency or adequacy of this First Supplemental Indenture or the Subordinated Notes. The recitals and statements herein and in the Subordinated Notes are deemed to be those of the Company and not the Trustee. In entering into this First
Supplemental Indenture, the Trustee shall be entitled to the benefit of every provision of the Base Indenture relating to the conduct of or affecting the liability of or affording protection to the Trustee. 

Section 4.04.    Governing Law. The Subordinated Notes Indenture and the Subordinated Notes shall be governed
by and construed in accordance with the laws of the State of New York (without giving effect to the choice of law provisions), except for Sections 12.01 and 12.02 of the Base Indenture, as amended and supplemented by this First Supplemental
Indenture, Section 2.01(r) of this First Supplemental Indenture and the status provisions of the Subordinated Notes, which shall be governed by and construed in accordance with the laws of the Kingdom of Spain, and except that the authorization
and execution by the Company of the Subordinated Notes Indenture and the Subordinated Notes shall be governed by (in addition to the laws of the State of New York relevant to execution) the respective jurisdictions of organization of the Company and
the Trustee, as the case may be. 
 Section 4.05.    Separability. In case any provision contained in this
First Supplemental Indenture shall be invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

Section 4.06.    Counterparts. This First Supplemental Indenture may be executed in any number of
counterparts, each of which so executed shall be deemed to be an original, but all such counterparts shall together constitute but one and the same instrument. The exchange of copies of this First Supplemental Indenture and of signature pages by
facsimile, email or other electronic format (i.e., “pdf”, “tif” or “jpg”) transmission and other electronically imaged signatures (including, without limitation, DocuSign and AdobeSign) shall constitute effective
execution and delivery of this First Supplemental Indenture as to the parties hereto and may be used in lieu of the original First Supplemental Indenture for all purposes. Signatures of the parties hereto transmitted by facsimile or electronic
format (i.e., “pdf” or “tif”) shall be deemed to be their original signatures for all purposes. This First Supplemental Indenture and any indenture supplemental hereto and any other document, certificate or opinion delivered in
connection with this First Supplemental Indenture, such supplemental indenture or the issuance and delivery of the Subordinated Notes may be signed by or on behalf of the Company and the Trustee by manual, facsimile or pdf or other electronically
imaged signature (including, without limitation, DocuSign and AdobeSign). 

  
 13 













 [Signature Pages Follow] 

  
 14 













 IN WITNESS WHEREOF, the parties hereto have caused this First Supplemental Indenture to be duly executed as
of the date first written above. 
  

							
	BANCO SANTANDER, S.A., as Issuer
			
	        	 	By:	 	 /s/ Antonio Torío Martín

		 		 	Name:	 	 Antonio Torío Martín

		 		 	Title:	 	Authorized Representative



  
 [Signature Page to
First Supplemental Indenture] 













 
							
	THE BANK OF NEW YORK MELLON, London Branch, as Trustee
			
	        	 	By:	 	 /s/ Melissa Laidley

		 		 	Name:	 	 Melissa Laidley

		 		 	Title:	 	Vice President



  
 [Signature Page to
First Supplemental Indenture] 













 
							
	THE BANK OF NEW YORK MELLON SA/NV, Luxembourg Branch, as Registrar
			
	        	 	By:	 	 /s/ Melissa Laidley

		 		 	Name:	 	Melissa Laidley
		 		 	Title:	 	Vice President



  
 [Signature Page to
First Supplemental Indenture] 













 EXHIBIT A 

FORM OF GLOBAL NOTE 
 THIS NOTE IS A
GLOBAL SECURITY AND IS REGISTERED IN THE NAME OF THE DEPOSITORY TRUST COMPANY AS THE DEPOSITARY (AS DEFINED IN THE SUBORDINATED NOTES INDENTURE GOVERNING THIS NOTE), OR ITS NOMINEE IN CUSTODY FOR THE BENEFIT OF THE BENEFICIAL OWNERS HEREOF, AND IS
NOT TRANSFERABLE TO ANY PERSON UNDER ANY CIRCUMSTANCES EXCEPT THAT (I) THE TRUSTEE MAY MAKE SUCH NOTATIONS HEREON AS MAY BE REQUIRED PURSUANT TO THE BASE INDENTURE, (II) THIS GLOBAL NOTE MAY BE EXCHANGED IN WHOLE BUT NOT IN PART PURSUANT
TO SECTION 3.05 OF THE BASE INDENTURE, (III) THIS GLOBAL NOTE MAY BE DELIVERED TO THE TRUSTEE FOR CANCELLATION PURSUANT TO SECTION 3.09 OF THE BASE INDENTURE AND (IV) THIS GLOBAL NOTE MAY BE TRANSFERRED TO A SUCCESSOR DEPOSITARY WITH THE
PRIOR WRITTEN CONSENT OF THE COMPANY. UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SUBORDINATED NOTES IN DEFINITIVE FORM, THIS NOTE MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF THE DEPOSITARY OR BY A NOMINEE
OF THE DEPOSITARY TO THE DEPOSITARY OR ANOTHER NOMINEE OF THE DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY. UNLESS THIS GLOBAL SECURITY IS PRESENTED BY AN AUTHORIZED
REPRESENTATIVE OF THE DEPOSITARY TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY GLOBAL SECURITY ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR SUCH OTHER NAME AS MAY BE REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF THE DEPOSITARY (AND ANY PAYMENT IS MADE TO CEDE & CO. OR SUCH OTHER ENTITY AS MAY BE REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITARY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO
ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 THE SUBORDINATION OF THIS NOTE IS SET FORTH
IN SECTIONS 12.01 AND 12.02 OF THE BASE INDENTURE, AS AMENDED AND SUPPLEMENTED BY THE FIRST SUPPLEMENTAL INDENTURE, AND SECTION 2.01(r) OF THE FIRST SUPPLEMENTAL INDENTURE, AND THIS NOTE IS ISSUED SUBJECT TO THE PROVISIONS OF SUCH SECTIONS 12.01,
12.02 AND 2.01(r), RESPECTIVELY, AND THE HOLDER OF THIS NOTE, BY ACCEPTING THE SAME, AGREES TO AND SHALL BE BOUND BY SUCH PROVISIONS. THE PROVISIONS OF SECTIONS 12.01 AND 12.02 OF THE BASE INDENTURE, AS AMENDED AND SUPPLEMENTED BY THE FIRST
SUPPLEMENTAL INDENTURE, SECTION 2.01(r) OF THE FIRST SUPPLEMENTAL INDENTURE AND THE TERMS OF THIS PARAGRAPH ARE GOVERNED BY, AND SHALL BE CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE KINGDOM OF SPAIN. 












 CUSIP No. 05971K AG4 

ISIN No. US05971KAG40 
 SERIES 100
2.749% TIER 2 SUBORDINATED FIXED RATE NOTES DUE 2030 
 Issued by 

BANCO SANTANDER, S.A. 
  

					
	 No.         
	  	$	         	 

 BANCO SANTANDER, S.A., a sociedad anónima, incorporated under the laws of the Kingdom of Spain (herein called
the “Company”, which term includes any successor person under the Subordinated Notes Indenture (as defined on the reverse hereof)), for value received, hereby promises to pay to CEDE & CO., or registered assigns, the principal sum
of $         (        dollars) on December 3, 2030 or on such earlier date as the principal hereof may become due in accordance with the terms hereof and to pay
interest thereon semi-annually in arrears on June 3 and December 3 of each year, commencing on June 3, 2021, and ending on December 3, 2030 (each, a “Payment Date”). Interest so payable on any Payment Date shall be paid
to the Holder in whose name this Note is registered on the 15th calendar day immediately preceding the relevant Payment Date, whether or not such day is a Business Day, as defined in the
Subordinated Notes Indenture (each a “Regular Record Date”). 
 Interest shall accrue on this Note from day to day from the date
of issuance hereof or from the most recent Payment Date at the rate of 2.749% per annum, until the principal amount hereof is paid or made available for payment. 

Payments of interest on this Note shall be computed on the basis of a 360-day year divided into twelve
months of 30 days each and, in the case of an incomplete month, the actual number of days elapsed in such month. 
 Payment of the principal
amount of and any interest on, this Note will be made by wire transfer of immediately available funds in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts. Such
payment shall be made to the Holder including through a Paying Agent of the Company for collection by the Holder. If the date for payment of the principal amount hereof or interest thereon is not a Business Day, then (subject as provided in the
Subordinated Notes Indenture) such payment shall be made on the next succeeding Business Day with the same force and effect as if made on such date for payment, provided that no interest shall accrue on such payment for the period from and after
such payment date. 
 The Subordinated Notes are issuable in minimum denominations of $200,000 and integral multiples of $200,000 in excess
thereof. 

  
 A-2 













 For information purposes only, without any substantive effect whatsoever and solely in order
to comply with Article 413(d) of the Spanish Companies Law (Ley de Sociedades de Capital), approved by Royal Decree 1/2010, of July 2, to the extent applicable, it is hereby noted that the initial aggregate principal amount of the
Subordinated Notes, i.e., US$1,500,000,000, was equivalent to approximately €1,252,050,000, based on the exchange rate as of November 30, 2020 of €0.8347 per US $1.00. Amounts due on the Notes shall not under any circumstances
whatsoever be payable in any currency other than U.S. Dollars. 
 Prior to due presentment of this Note for registration of transfer, the
Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name this Note is registered as the owner of such Note for the purpose of receiving payment of principal and interest, if any, on and any Additional
Amounts with respect to such Note and for all other purposes whatsoever, whether or not such Note be overdue, and neither the Company, the Trustee nor any agent of the Company or the Trustee shall be affected by notice to the contrary. 

Reference is hereby made to the further provisions of this Note set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 Unless the certificate of authentication hereon has been executed by the
Trustee referred to on the reverse hereof by manual signature, this Note shall not be entitled to any benefit under the Subordinated Notes Indenture or be valid or obligatory for any purpose. 

Notwithstanding any other term of this Note or any other agreements, arrangements, or understandings between the Company and any Holder of the
Subordinated Notes, by its acquisition of this Note, each Holder (which includes each holder of a beneficial interest in this Note) acknowledges, accepts, consents to and agrees: 

(i) to be bound by effect of the exercise of the Bail-in Power by the Relevant Resolution Authority,
which may include and result in any of the following, or some combination thereof: 
  

	 	•	 	 the reduction of all, or a portion, of the Amounts Due on a permanent basis; 



 

	 	•	 	 the conversion of all, or a portion, of the Amounts Due into shares, other securities or other obligations of the
Company or another person (and the issue to the Holder of such shares, securities or obligations), including by means of an amendment, modification or variation of the terms of the Subordinated Notes, in which case the Holder agrees to accept in
lieu of its rights under this Note any such shares, other securities or other obligations of the Company or another person; 


  

	 	•	 	 the cancellation of this Note or Amounts Due; 



 

	 	•	 	 the amendment or alteration of the maturity of this Note or amendment of the interest payable on this Note, or
the date on which the interest becomes payable, including by suspending payment for a temporary period; and 


 (ii) that
the terms of this Note are subject to, and may be varied, if necessary, to give effect to, the exercise of the Bail-in Power by the Relevant Resolution Authority. 

  
 A-3 













 “Amounts Due” means the principal amount of, premium, if any, together with any
accrued but unpaid interest, and Additional Amounts, if any, due on the Subordinated Notes. References to such amounts will include amounts that have become due and payable, but which have not been paid, prior to the exercise of the Bail-in Power by the Relevant Resolution Authority. 

“Bail-in Power” means any power existing from time to time under, and exercised in
compliance with, any laws, regulations, rules or requirements in effect in the Kingdom of Spain, relating to (i) the transposition of the BRRD (including but not limited to, Law 11/2015, RD 1012/2015 and any other implementing regulations), as
amended or superseded from time to time, (ii) the SRM Regulation and (iii) the instruments, rules or standards created thereunder, pursuant to which any obligation of a Regulated Entity (or an affiliate of such Regulated Entity) can be
reduced, cancelled, suspended, modified, or converted into shares, other securities, or other obligations of such Regulated Entity (or affiliate of such Regulated Entity). 

“BRRD” means Directive 2014/59/EU of 15 May establishing the framework for the recovery and resolution of credit institutions
and investment firms or such other directive as may amend or come into effect in place thereof (including the BRRD II), as implemented into law by Law 11/2015 and RD 1012/2015, as amended or replaced from time to time and including any other
relevant implementing regulatory provisions. 
 “BRRD II” means Directive (EU) 2019/879 of the European Parliament and of the
Council of 20 May 2019 amending Directive 2014/59/EU as regards the loss-absorbing and recapitalisation capacity of credit institutions and investment firms and Directive 98/26/EC. 

“RD 1012/2015” means Royal Decree 1012/2015, of 6 November developing Law 11/2015, as amended or superseded from time to time.

 “Regulated Entity” means any entity to which BRRD, as implemented in the Kingdom of Spain (including but not limited to, Law
11/2015, RD 1012/2015 and any other implementing regulations) and as amended or superseded from time to time, or any other Spanish law relating to the Bail-in Power, applies, which includes, certain credit
institutions, investment firms, and certain of their parent or holding companies. 
 “Relevant Resolution Authority” means the
Spanish Fund for the Orderly Restructuring of Banks, the Bank of Spain, the European Single Resolution Board, as the case may be, according to Law 11/2015, and any other entity with the authority to exercise the
Bail-in Power or any other resolution power from time to time. 
 “SRM Regulation” means
Regulation (EU) No. 806/2014 of the European Parliament and of the Council of 15 July 2014, establishing uniform rules and a uniform procedure for the resolution of credit institutions and certain investment firms in the framework of the
Single Resolution Mechanism and the Single Resolution Fund and amending Regulation (EU) No. 1093/2010, as amended or replaced from time to time (including by the SRM Regulation II). 

“SRM Regulation II” means Regulation (EU) 2019/877 of the European Parliament and of the Council of 20 May 2019 amending
Regulation (EU) No 806/2014 as regards the loss-absorbing and recapitalization capacity of credit institutions and investment firms. 

  
 A-4 













 The public deed of issuance (escritura de emisión) related to the Subordinated
Notes represented hereby was executed on December 2, 2020 before Mr. Gonzalo Sauca Polanco with the number 5,496 of his records. 

  
 A-5 













 IN WITNESS WHEREOF, the Company has caused this Note to be duly executed. 

Dated: December 3, 2020 
  

	
	BANCO SANTANDER, S.A.
	
	By:                                     
                               
	Name:
	Title:


 [Global Note Signature Page] 

  
 A-6 













 CERTIFICATE OF AUTHENTICATION 

This is one of the Subordinated Debt Securities of the series designated herein referred to in the within-mentioned Subordinated Notes
Indenture. 
 Dated: December 3, 2020 
  

	
	THE BANK OF NEW YORK MELLON,
	London Branch, as Trustee
	
	By:                                     
                               
	 Authorized Signatory



 [Global Note Signature Page] 

  
 A-7 













 [REVERSE OF SECURITY] 

This Note is one of a duly authorized issue of securities of the Company of the series designated Series 100 2.749% Tier 2 Subordinated Fixed
Rate Notes due 2030 (herein called the “Subordinated Notes”) issued and to be issued in one or more series under a Subordinated Notes Indenture, dated as of December 3, 2020 (herein called the “Base Indenture”), between the
Company, as issuer and The Bank of New York Mellon, London Branch, as Trustee (herein called the “Trustee”, which term includes any successor trustee under the Base Indenture), as amended and supplemented by the First Supplemental
Indenture, dated as of December 3, 2020, among the Company, the Trustee and The Bank of New York Mellon, Luxembourg Branch, as Subordinated Debt Securities Registrar (the “First Supplemental Indenture”, and, together with the Base
Indenture, the “Subordinated Notes Indenture”) to which Subordinated Notes Indenture and all indentures supplemental thereto reference is hereby made for a statement of the respective rights, limitations of rights, duties and immunities
thereunder of the Company and the Trustee and the Holders of the Subordinated Notes and of the terms upon which the Subordinated Notes are, and are to be, authenticated and delivered. Capitalized terms used herein are used as defined in the
Subordinated Notes Indenture unless otherwise indicated. The terms of the Subordinated Notes include those stated in the Subordinated Notes Indenture. The Subordinated Notes are subject to all such terms, and Holders are referred to the
Subordinated Notes Indenture for a statement of all such terms. To the extent permitted by applicable law, in the event of any inconsistency between the terms of this Subordinated Note and the terms of the Subordinated Notes Indenture, the
terms of the Subordinated Notes Indenture will control. 
 This Note is one of the series designated on the face hereof, initially limited
in aggregate principal amount to $1,500,000,000; provided, that the Company may, from time to time, without the consent of the Holders of the Subordinated Notes, issue additional Subordinated Debt Securities under the Subordinated Notes Indenture,
having the same ranking and same interest rate, maturity, redemption terms and other terms, except for the price to the public, original interest accrual date, issue date and first interest payment date, as the Subordinated Notes; provided,
however, that such additional Subordinated Notes will not have the same CUSIP, ISIN or other identifying number as the outstanding Subordinated Notes unless the additional Subordinated Notes are fungible with the Subordinated Notes for U.S. federal
income tax purposes. Any such additional Subordinated Notes, together with the Subordinated Notes, will constitute a single series of Subordinated Notes under the Subordinated Notes Indenture and shall be included in the definition of
“Subordinated Debt Securities” in the Base Indenture where the context requires. 
 The payment obligations of the Company under
the Subordinated Notes on account of principal constitute direct, unconditional, unsecured and subordinated obligations (créditos subordinados) of the Company according to Article 281.1.2o of the Insolvency Law (Ley Concursal)
approved by the Royal Decree-Legislative 1/2020, of 5 May (the “Spanish Insolvency Law”) and, in accordance with Additional Provision 14.3o of Law 11/2015, but subject to any other ranking that may apply as a result of any
mandatory provision of law (or otherwise), upon the insolvency of the Company rank for so long as the obligations of the Company in respect of the Subordinated Notes constitute Tier 2 Instruments (as defined below): (i) pari passu
among themselves and with (a) all other claims for principal in respect of Tier 2 Instruments which are not subject to any other ranking that may apply as a result of any mandatory provision of law (or otherwise), and (b) any other
subordinated obligations (créditos subordinados) which by law 

  
 A-8 













 
and/or by their terms, to the extent permitted by Spanish law, rank pari passu with the Company’s obligations under the Subordinated Notes; (ii) junior to (a) any
unsubordinated obligations (créditos ordinarios) of the Company (including any Senior Non Preferred Liabilities (as defined below)), (b) any claim for principal in respect of Senior Subordinated Liabilities (as defined below)
which are not subject to any other ranking that may apply as a result of any mandatory provision of law (or otherwise) and (c) any other subordinated obligations (créditos subordinados) which by law and/or by their terms,
to the extent permitted by Spanish law, rank senior to the Company’s obligations under the Subordinated Notes; and (iii) senior to (a) any claims for principal in respect of Additional Tier 1 Instruments (as defined below) of the
Company, and (b) any other subordinated obligations (créditos subordinados) of the Company which by law and/or by their terms, to the extent permitted by Spanish law, rank junior to the obligations of the Company under the
Subordinated Notes. 
 The Company agrees with respect to the Subordinated Notes and each Holder of the Subordinated Notes, by his or her
acquisition of a Subordinated Note, will be deemed to have agreed to the above described subordination. Each such Holder will be deemed to have irrevocably waived his or her rights of priority which would otherwise be accorded to him or her under
the laws of Spain, to the extent necessary to effectuate the subordination provisions of the Subordinated Notes. In addition, each Holder of the Subordinated Notes by his or her acquisition of the Subordinated Notes authorizes and directs the
Trustee on his or her behalf to take such action as may be necessary or appropriate to effectuate the subordination of the Subordinated Notes as provided in the Subordinated Notes Indenture and as summarized herein and appoints the Trustee as his or
her attorney-in-fact for any and all such purposes. 

Claims of Holders of the Subordinated Notes in respect of interest accrued but unpaid as of the commencement of any insolvency procedure in
respect of the Company shall constitute subordinated claims (créditos subordinados) against the Company ranking in accordance with the provisions of Article 281.1.3o of the Spanish Insolvency Law and no further interest shall accrue from
the date of the declaration of insolvency of the Company. 
 The obligations of the Company under the Subordinated Notes are subject
to the Bail-in Power. 
 “Additional Tier 1 Instrument” means any contractually
subordinated obligation (créditos subordinados) of the Company according to Article 281.1.2o of the Spanish Insolvency Law, ranking as an additional tier 1 instrument (instrumentos de capital adicional de nivel 1)
under Additional Provision 14.3o(c) of Law 11/2015. 
 “Law 11/2015” means Law 11/2015 of 18 June, on recovery and
resolution of credit institutions and investment firms (Ley 11/2015, de 18 de junio, de recuperación y resolución de entidades de crédito y empresas de servicios de inversión) as amended or replaced from
time to time. 
 “Senior Non Preferred Liabilities” means any unsubordinated and unsecured senior non preferred obligations
(créditos ordinarios no preferentes) of the Company under Additional Provision 14.2o of Law 11/2015 and any other obligations which, by law and/or by their terms, and to the extent permitted by Spanish law, rank pari
passu with the Senior Non Preferred Liabilities. 

  
 A-9 













 “Senior Subordinated Liabilities” means any contractually subordinated obligation
(créditos subordinados) of the Company according to Article 281.1.2o of the Spanish Insolvency Law, ranking as subordinated debt which is not an Additional Tier 1 Instrument or a Tier 2 Instrument (deuda subordinada que
no sea capital adicional de nivel 1 o 2) under Additional Provision 14.3o(a) of Law 11/2015. 
 “Tier 2 Instrument” means
any contractually subordinated obligation (créditos subordinados) of the Company according to Article 281.1.2o of the Spanish Insolvency Law, ranking as a tier 2 instrument (instrumentos de capital de nivel 2) under
Additional Provision 14.3o(b) of Law 11/2015. 
 The provisions of Sections 12.01 and 12.02 of the Base Indenture, as amended and
supplemented by the First Supplemental Indenture, and Section 2.01(r) of the First Supplemental Indenture shall apply only to rights or claims payable with respect to the Subordinated Notes and nothing herein shall affect or prejudice the
payment of the costs, charges, expenses, liabilities, indemnity or remuneration of the Trustee, the first lien rights of the Trustee under Section 6.08 of the Base Indenture, or the rights and remedies of the Trustee in respect thereof. 

Notwithstanding any other term of this Note or any other agreements, arrangements, or understandings between the Company and any Holder of the
Subordinated Notes, by its acquisition of this Note, each Holder (which includes each holder of a beneficial interest in this Note) acknowledges, accepts, consents to and agrees: 

(i) to be bound by effect of the exercise of the Bail-in Power by the Relevant Resolution Authority,
which may include and result in any of the following, or some combination thereof: 
  

	 	•	 	 the reduction of all, or a portion, of the Amounts Due on a permanent basis; 



 

	 	•	 	 the conversion of all, or a portion, of the Amounts Due into shares, other securities or other obligations of the
Company or another person (and the issue to the Holder of such shares, securities or obligations), including by means of an amendment, modification or variation of the terms of this Note, in which case the Holder agrees to accept in lieu of its
rights under this Note any such shares, other securities or other obligations of the Company or another person; 


  

	 	•	 	 the cancellation of this Note or Amounts Due; 



 

	 	•	 	 the amendment or alteration of the maturity of this Note or amendment of the interest payable on this Note, or
the date on which the interest becomes payable, including by suspending payment for a temporary period; and 


 (ii) that
the terms of this Note are subject to, and may be varied, if necessary, to give effect to, the exercise of the Bail-in Power by the Relevant Resolution Authority. 

“Amounts Due” means the principal amount of, premium, if any, together with any accrued but unpaid interest, and Additional Amounts,
if any, due on the Subordinated Notes. References to such amounts will include amounts that have become due and payable, but which have not been paid, prior to the exercise of the Bail-in Power by the Relevant
Resolution Authority. 

  
 A-10 













 “Bail-in Power” means any power existing
from time to time under, and exercised in compliance with, any laws, regulations, rules or requirements in effect in the Kingdom of Spain, relating to (i) the transposition of the BRRD (including but not limited to, Law 11/2015, RD 1012/2015
and any other implementing regulations), as amended or superseded from time to time, (ii) the SRM Regulation and (iii) the instruments, rules or standards created thereunder, pursuant to which any obligation of a Regulated Entity (or an
affiliate of such Regulated Entity) can be reduced, cancelled, suspended, modified, or converted into shares, other securities, or other obligations of such Regulated Entity (or affiliate of such Regulated Entity). 

“BRRD” means Directive 2014/59/EU of 15 May establishing the framework for the recovery and resolution of credit institutions
and investment firms or such other directive as may amend or come into effect in place thereof (including the BRRD II), as implemented into law by Law 11/2015 and RD 1012/2015, as amended or replaced from time to time and including any other
relevant implementing regulatory provisions. 
 “BRRD II” means Directive (EU) 2019/879 of the European Parliament and of the
Council of 20 May 2019 amending Directive 2014/59/EU as regards the loss-absorbing and recapitalisation capacity of credit institutions and investment firms and Directive 98/26/EC. 

“RD 1012/2015” means Royal Decree 1012/2015, of 6 November developing Law 11/2015, as amended or superseded from time to time.

 “Regulated Entity” means any entity to which BRRD, as implemented in the Kingdom of Spain (including but not limited to, Law
11/2015, RD 1012/2015 and any other implementing regulations) and as amended or superseded from time to time, or any other Spanish law relating to the Bail-in Power, applies, which includes, certain credit
institutions, investment firms, and certain of their parent or holding companies. 
 “Relevant Resolution Authority” means the
Spanish Fund for the Orderly Restructuring of Banks, the Bank of Spain, the European Single Resolution Board, as the case may be, according to Law 11/2015, and any other entity with the authority to exercise the
Bail-in Power or any other resolution power from time to time. 
 “SRM Regulation” means
Regulation (EU) No. 806/2014 of the European Parliament and of the Council of 15 July 2014, establishing uniform rules and a uniform procedure for the resolution of credit institutions and certain investment firms in the framework of the
Single Resolution Mechanism and the Single Resolution Fund and amending Regulation (EU) No. 1093/2010, as amended or replaced from time to time (including by the SRM Regulation II). 

“SRM Regulation II” means Regulation (EU) 2019/877 of the European Parliament and of the Council of 20 May 2019 amending
Regulation (EU) No 806/2014 as regards the loss-absorbing and recapitalization capacity of credit institutions and investment firms. 
 The
exercise of the Bail-in Power by the Relevant Resolution Authority with respect to the Subordinated Notes shall not constitute an event of default and the terms and conditions of the Subordinated Notes shall
continue to apply in relation to the residual principal amount of, or 

  
 A-11 













 
outstanding amount payable with respect to, the Subordinated Notes subject to any modification of the amount of distributions payable to reflect the reduction of the principal amount, and any
further modification of the terms that the Relevant Resolution Authority may decide in accordance with applicable laws and regulations relating to the resolution of credit institutions, investment firms and/or Company entities incorporated in the
relevant member state. 
 No repayment or payment of Amounts Due, if any, on the Subordinated Notes, will become due and payable or be paid
after the exercise of any Bail-in Power by the Relevant Resolution Authority if and to the extent such amounts have been reduced, converted, cancelled, amended or altered as a result of such exercise. 

By its acquisition of this Note, each Holder of this Note, (which, for the purposes of this clause, includes each holder of a beneficial
interest in this Note), to the extent permitted by the Trust Indenture Act, will waive any and all claims, in law and/or in equity, against the Trustee for, agree not to initiate a suit against the Trustee in respect of, and agree that the Trustee
will not be liable for, any action that the Trustee takes, or abstains from taking, in either case in accordance with the exercise of the Bail-in Power by the Relevant Resolution Authority with respect to this
Note. 
 Additionally, by its acquisition of this Note, each Holder of this Note acknowledges and agrees that, upon the exercise of the Bail-in Power by the Relevant Resolution Authority: 
 (i) the Trustee will not be required to take any
further directions from the Holders of the Subordinated Notes with respect to any portion of the Subordinated Notes that are written-down, converted to equity and/or cancelled under the Subordinated Notes Indenture, which authorizes holders of a
majority in aggregate outstanding principal amount of the outstanding Subordinated Notes to direct certain actions relating to the Subordinated Notes; and 

(ii) the Subordinated Notes Indenture will not impose any duties upon the Trustee whatsoever with respect to the exercise of the Bail-in Power by the Relevant Resolution Authority; 
 provided, however, that notwithstanding the
exercise of the Bail-in Power by the Relevant Resolution Authority, so long as the Subordinated Notes remain outstanding, there will at all times be a Trustee for the Subordinated Notes in accordance with the
Subordinated Notes Indenture, and the resignation and/or removal of the Trustee and the appointment of a successor Trustee will continue to be governed by the Base Indenture, including to the extent no additional supplemental indenture or amendment
is agreed upon in the event the Subordinated Notes remain outstanding following the completion of the exercise of the Bail-in Power. 

By its acquisition of this Note, each Holder of this Note acknowledges and agrees that neither a cancellation or deemed cancellation of the
principal or interest (in each case, in whole or in part), nor the exercise of the Bail-in Power by the Relevant Resolution Authority with respect to the Subordinated Notes will give rise to a default for
purposes of Section 315(b) (Notice of Default) and Section 315(c) (Duties of the Trustee in Case of Default) of the Trust Indenture Act. 

By purchasing this Note, each Holder (including each beneficial owner) of this Note shall be deemed to have authorized, directed and requested
DTC and any direct participant in DTC or 

  
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other intermediary through which it holds this Note to take any and all necessary action, if required, to implement the exercise of the Bail-in Power with
respect to the Subordinated Notes as it may be imposed, without any further action or direction on the part of such Holder. 
 Each Holder
of this Note also acknowledges and agrees that the foregoing description of the Bail-in Power and its exercise is exhaustive on the matters described herein to the exclusion of any other agreements,
arrangements or understandings relating to the application of any Bail-in Power to the Subordinated Notes. 

Each Holder of this Note that acquires such Subordinated Notes in the secondary market (including each beneficial owner) shall be deemed to
acknowledge, agree to be bound by and consent to the same provisions specified herein to the same extent as the Holders of the Subordinated Notes that acquire the Subordinated Notes upon their initial issuance, including, without limitation, with
respect to the acknowledgment and agreement to be bound by and consent to the terms of the Subordinated Notes, including in relation to the Bail-in-Power. 

Additional terms of the Subordinated Notes, including but not limited to events of default, remedies, payment of additional amounts in respect
of withholding tax, substitution and variation of the Subordinated Notes upon certain regulatory events, and amendment are set forth in the Subordinated Notes Indenture. 

The Subordinated Notes Indenture and the Subordinated Notes shall be governed by and construed in accordance with the laws of the State of New
York (without giving effect to the choice of law provisions), except for Sections 12.01 and 12.02 of the Base Indenture, as amended and supplemented by the First Supplemental Indenture, Section 2.01(r) of the First Supplemental Indenture
and the status of the Subordinated Notes, which shall be governed by and construed in accordance with the laws of The Kingdom of Spain, and except that the authorization and execution by the Company of the Subordinated Notes Indenture and the
Subordinated Notes shall be governed by (in addition to the laws of the State of New York relevant to execution) the respective jurisdictions of organization of the Company and the Trustee, as the case may be. 

The Subordinated Notes and this Note have been issued in the State of New York. 

  
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