| 1.   | DEFINITIONS |
|----------------|-------------|

| (a)   | Cause |
|-----------------|-------|

| (b)   | Good      Reason |
|-----------------|------------------|

| 2.   | TERM |
|----------------|------|

| 3.   | DUTIES      AND SERVICES |
|----------------|--------------------------|

| 4.   | COMPENSATION      AND OTHER BENEFITS |
|----------------|--------------------------------------|

| (a)   | Salary |
|-----------------|--------|

| (b)   | Annual      Bonus |
|-----------------|-------------------|

| (c)   | Benefits |
|-----------------|----------|

| (d)   | Equity |
|-----------------|--------|

| 5.   | NON-COMPETITION |
|----------------|-----------------|

| 6.   | CONFIDENTIAL      INFORMATION |
|----------------|-------------------------------|

| 7.   | TERMINATION |
|----------------|-------------|

| (a)   | Termination      by the Company for Cause |
|-----------------|-------------------------------------------|

| (b)   | Termination      Without Cause or Termination For GoodReason |
|-----------------|--------------------------------------------------------------|

| (c)   | Termination      Due to Death or Disability |
|-----------------|---------------------------------------------|

| (d)   | Voluntary      Termination |
|-----------------|----------------------------|

| (e)   | Termination      by the Company at End of EmploymentPeriod |
|-----------------|------------------------------------------------------------|

| 8.   | SURVIVAL |
|----------------|----------|

| 9.   | NOTICES |
|----------------|---------|

| 10.   | WAIVER |
|-----------------|--------|

| 11.   | SUCCESSORS |
|-----------------|------------|

| (a)   | Effect      on Employee |
|-----------------|-------------------------|

| (b)   | Effect      on Company |
|-----------------|------------------------|

| 12.   | NO      THIRD PARTY BENEFICIARIES |
|-----------------|-----------------------------------|

| 13.   | GOVERNING      LAW |
|-----------------|--------------------|

| 14.   | SEVERABILITY |
|-----------------|--------------|

| 15.   | NO      VIOLATION OF OUTSTANDINGAGREEMENT(S) |
|-----------------|----------------------------------------------|

|  NEUROGEN      CORPORATION                                   |   |   |  EMPLOYEE                                                                           |   |
|-------------------------------------------------------------------|--------|--------|------------------------------------------------------------------------------------------|--------|
|                                                              |   |   |                                                                                     |   |
| /s/      Stephen R. Davis                                         |   |   | /s/      Kenneth Sprenger                                                                |   |
| Name:        Stephen R. Davis                           |   |   | Name:       Kenneth Sprenger                                                        |   |
| Title:   President and Chief      Executive Office |   |   | Title:         Senior Vice President, Clinical Development and Operations |   |