Docket Number: EPA-HQ-OPP-2010-0454 

www.regulations.gov

United States Chemical Safety September 2010 

 Environmental Protection and Pollution Prevention 

 Agency (7510P) 

 

Copper 8-quinolinolateSummary 

Document: Registration Review 

Docket Number: EPA-HQ-OPP-2010-0454 

www.regulations.gov

TABLE OF CONTENTS 

Copper 8-quinolinotate 

Registration Review Team ............................................................................................... 4 

I. PRELIMINARY WORK PLAN – Copper 8-quinolinolate ...................................... 5 

II. FACT SHEET ............................................................................................................ 14 

III. GLOSSARY OF TERMS & ABBREVIATIONS ................................................. 19 

IV. APPENDIX A............................................................................................................ 21 

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Copper 8-quinolinolate 

Registration Review Team 

Human Health & Environmental Effects 

William J. Hazel 

Srinivas Gowda 

Risk Management

Rebecca von dem Hagen 

Lance Wormell 

Office of General Counsel

Philip Ross 

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I. PRELIMINARY WORK PLAN – Copper 8-quinolinolate 

Introduction

The Food Quality Protection Act (FQPA) of 1996 mandated a registration review 

program. All pesticides distributed or sold in the United States generally must be 

registered by the U.S. Environmental Protection Agency (USEPA, EPA, or the Agency), 

based on scientific data showing that they will not cause unreasonable risks to human 

health or the environment when used as directed on product labeling. The registration 

review program is intended to make sure that, as the ability to assess risk evolves and as 

policies and practices change, all registered pesticides continue to meet the statutory 

standard of no unreasonable adverse effects to human health or the environment. Changes 

in science, public policy, and pesticide use practices will occur over time. Through the 

registration review program, the Agency periodically reevaluates pesticides to make sure 

that as change occurs, products in the marketplace can be used safely. Information on 

this program is provided at http://www.epa.gov/oppsrrd1/registration_review/. 

The Agency is implementing the registration review program pursuant to Section 

3(g) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and will review 

each registered pesticide every 15 years to determine whether it continues to meet the 

FIFRA standard for registration. The Agency will consider benefits information and data 

as required by FIFRA. The public phase of registration review begins when the initial 

docket is opened for each case. The docket is the Agency’s opportunity to state what it 

knows about the pesticide and what additional risk analyses and data or information it 

believes are needed to make a registration review decision. After reviewing and 

responding to comments and data received in the docket during this initial comment 

period, the Agency will develop and commit to a final work plan and schedule for the 

registration review of copper 8-quinolinolate. 

Copper 8-quinolinolate is registered for use as a wood preservative for control of 

sapstain, mold and decay in unfinished wood and wood products such as millwork, 

siding, decks, outdoor furniture, shingles, structural lumber, boats, decks and baseboards. 

Treated wood materials may be used in contact with fruit, vegetables and other foodstuffs 

in areas such as greenhouses and greenhouse items, produce picking boxes, mushroom 

trays and vegetable stakes. The chemical is also registered for use as a disinfectant to 

control potato ring rot in planters, seed handling equipment, seed cutters, storage areas 

and transportation equipment. Copper 8-quinolinolate is registered for use in the 

manufacture of kraft paper, paperboard, backerboard, adhesives, and paints as a fungicide 

and mildewicide. In addition, this chemical is registered for use as a material 

preservative to control mold and mildew on industrial and military textiles such as 

canvas, burlap, rope, leather and nets (non-aquatic uses only). 

Copper 8-quinolinolate (PC Code 024002) was first registered in the United 

States in 1956 and currently there are 29 registrations, 2 manufacturing use products 

(MUPs) and 27 end use products (EUPs). EPA previously reevaluated copper 8-

quinolinolate as part of the Copper Salts Reregistration case, Case Number 4026. 

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Because copper 8-quinolinolate is toxicologically unique from elemental copper and, 

therefore, potentially subject to different risk assessments, data needs, and labeling 

changes, EPA completed a separate RED for copper 8-quinolinolate in September 2007. 

To minimize future confusion between copper 8-quinolinolate and other copper 

compounds, the Agency created a new Registration Review case for copper-8-

quinolinolate, Case Number 5118. As part of the Reregistration process, a data call-in 

(DCI) was issued in June 2010. The copper 8-quinolinolate RED can be viewed at 

http://www.regulations.gov in docket number EPA-HQ-OPP-2007-0556. 

Risk Assessment Status & Anticipated Data Needs

Human Health Risk Assessment Status and Anticipated Data Needs 

The Agency has reviewed all the available information on toxicology and human 

exposure regarding copper 8-quinolinolate. As a result of this review, EPA confirmed 

that the data being called-in through the recently issued Reregistration DCI are still 

needed. The Agency does not anticipate the need to require any other human health data 

for copper 8-quinolinolate for this registration review. 

Further human health information is available in the document titled “Human 

Health Effects Data for Copper 8-quinolinolate Registration Review Decision,” dated 

August 30, 2010. 

Dietary and Drinking Water Assessment

Dietary Exposure 

 Chronic dietary exposure and risk were assessed in the 2007 RED for copper 8-

quinolinolate due to copper 8-quinolinolate’s potential to migrate into food through 

pulp/paper and adhesives. EPA will update the chronic dietary risk assessment used to 

support the 2007 RED as appropriate including an assessment of risk associated with the 

migration of copper 8-quinolinolate from treated wood into food. Information to assess 

the migration from treated wood into food was not available at the time of the RED and 

those data were required through a 2010 Reregistration DCI. The Agency does not 

anticipate conducting an acute dietary risk assessment because, as stated in the 2007 

RED, copper 8-quinolinolate does not cause adverse systemic effects resulting from a 

single dose. 

Drinking Water Exposure 

The need for a drinking water exposure assessment will be determined upon 

submission and review of leaching data being called in through the 2010 Reregistration 

DCI. 

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Tolerances

Copper 8-quinolinolate is cleared by the U.S. Food and Drug Administration 

(FDA) as an indirect food additive for use as a component in food packaging adhesives 

[21 CFR § 175.105(c)]; in paper and paperboard in contact with aqueous and fatty foods 

(21 CFR § 176.170); in paper and paperboard in contact with dry foods (21 CFR § 

176.180); and to preserve wooden articles intended for use in packaging, transporting, or 

holding raw agricultural products [21 CFR 178.3800(b)]. 

 There are no EPA established tolerances or exemptions from tolerances associated 

with the active ingredient copper 8-quinolinolate. 

Aggregate and Cumulative Exposure

 In examining aggregate exposure, EPA takes into account the available and 

reliable information concerning exposures to pesticide residues in food and drinking 

water, as well as non-occupational pesticide exposures. Based on current use patterns, an 

aggregate risk assessment is anticipated as being needed for copper 8-quinolinolate for 

dietary (food) and residential exposure. The need for a drinking water exposure 

assessment and the inclusion of drinking water exposure in the aggregate assessment will 

be determined by the review of leaching data being called in through the 2010 

Reregistration DCI. 

 Section 40(b)(2)(D)(v) of FFDCA requires that, when considering whether to 

establish, modify, or revoke a tolerance, the Agency considers “available information” 

concerning the cumulative effects of a particular pesticide’s residues and “other 

substances that have a common mechanism of toxicity.” EPA has not yet determined 

whether copper 8-quinolinolate has a common mechanism with other compounds; 

consequently a cumulative assessment will not be performed at this time. 

Occupational and Residential Assessment and Risk

 An occupational and/or residential exposure assessment is required for an active 

ingredient if (1) certain toxicological criteria are triggered and (2) there is potential 

exposure to handlers (mixers, loaders, applicators, etc.) during use or to persons entering 

treated sites after application is complete. The Agency reviewed all available 

information associated with copper 8-quinolinolate and determined that the currently 

registered uses of copper 8-quinolinolate may result in both occupational and residential 

exposure. 

Occupational Exposure 

Occupational handler dermal and inhalation scenarios as well as post-application 

exposure scenarios were assessed for the 2007 copper 8-quinolinolate RED. All assessed 

scenarios were determined not to exceed the Agency’s level of concern except for the 

wood preservative scenario. Because the scenarios used to estimate risk from exposure 

through wood preservative uses relied on conservative assumptions, EPA considered the 

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use eligible for reregistration but required confirmatory data through a 2010 

Reregistration DCI. Once these data are received, EPA intends to review the data and 

update the wood preservative scenario. 

The Agency reviewed the 2007 risk assessment and determined that the data 

being called in through the 2010 Reregistration DCI are still needed. The Agency does 

not anticipate the need to require any additional occupational exposure data for copper 8-

quinolinolate for this registration review. 

Residential Exposure 

 Residential handler dermal and inhalation exposure scenarios as well as 

residential post-application exposure scenarios were assessed for the 2007 copper 8-

quinolinolate RED. All residential exposure assessments, both handler and postapplication, were determined not to exceed the Agency’s level of concern. The Agency 

reviewed the 2007 risk assessment and determined that the data being called in through 

the 2010 Reregistration DCI are still needed. The Agency does not anticipate the need to 

require any other residential exposure data for copper 8-quinolinolate for this registration 

review. 

Product Chemistry Status and Anticipated Data Needs 

All product chemistry data requirements have been fulfilled for copper 8-

quinolinolate. Therefore, the Agency does not anticipate requiring additional product 

chemistry data for copper 8-quinolinolate for this registration review. 

For further information please refer to the Summary of Product Chemistry, 

Environmental Fate, and Ecotoxicity Data for the Copper 8-quinolinolate Registration 

Review Decision Document, dated July 30, 2010. 

Environmental Fate and Ecological Risk Assessment Status and Anticipated Data 

Needs

The Agency does not expect to require additional data through the registration 

review process. The data being called in as a result of the June 2010 Reregistration DCI 

will be evaluated and used to support the registration review risk assessments for copper 

8-quinolinolate. 

Further information and detailed justification for the studies that are expected to 

be required are available in the document titled, Summary of Product Chemistry, 

Environmental Fate, and Ecotoxicity Data for the Copper 8-quinolinolate Registration 

Review Decision Document, dated July 30, 2010. 

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Endangered Species 

The Agency has not conducted a risk assessment that supports a complete 

endangered species determination for copper 8-quinolinolate. The ecological risk 

assessment planned during registration review will allow the Agency to determine 

whether use of copper 8-quinolinolate has “no effect” or “may affect” federally listed 

threatened or endangered species (listed species) or their designated critical habitats. 

When an assessment concludes that a pesticide’s use “may affect” a listed species or its 

designated critical habitat, the Agency will consult with the U.S. Fish and Wildlife 

Service and/or National Marine Fisheries Service (the Services), as appropriate. 

Incidents:

Ecological 

There are no reported incidents in the Agency’s Ecological Incident Information 

System (EIIS) involving copper 8-quinolinolate. The absence of documented incidents 

does not necessarily mean that incidents did not occur. 

Human Health 

A small number of incidents (eight) have been reported that have a likely 

association with exposure to end-use products containing copper 8-quinolinolate. These 

occurred in California between 1982 and 2004. The skin and eyes were the primary 

routes of exposure and the resulting symptom was irritation. No severe incidents have 

been reported as being associated with copper 8-quinolinolate exposure. 

Timeline:

EPA has created the following estimated timeline for the completion of the copper 

8-quinolinolate registration review: 

Anticipated Schedule

Activities Estimated Month/Year

Phase 1: Opening the docket 

Open Public Comment Period for Copper 8-quinolinolate Docket September 2010 

Close Public Comment Period November 2010 

Phase 2: Case Development 

Develop Final Work Plan (FWP) February 2011 

Open Public Comment Period for Preliminary Risk Assessments June 2013 

Close Public Comment Period September 2013 

Phase 3: Registration Review Decision 

Open Public Comment Period for Proposed Reg. Review Decision December 2014 

Close Public Comment Period March 2015 

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Final Decision and Begin Post-Decision Follow-up 2015 

Total (years) 5 

Guidance for Respondents:

The public is invited to comment on EPA’s preliminary registration review work 

plan and rationale. The Agency will carefully consider all comments as well as any 

additional information or data provided in a timely manner prior to issuing a final work 

plan for the copper 8-quinolinolate registration review case. 

Trade Irritants 

Through the registration review process, the Agency intends to solicit information 

on trade irritants and, to the extent feasible, take steps toward facilitating irritant 

resolution. Growers and other stakeholders are asked to comment on any trade irritant 

issues resulting from lack of Maximum Residue Limits (MRLs) or disparities between 

U.S. tolerances and MRLs in key export markets, providing as much specificity as 

possible regarding the nature of the concern. 

Water Quality 

Copper 8-quinolinolate is not identified as a cause of impairment for any water 

bodies listed as impaired under section 303(d) of the Clean Water Act, based on 

information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation_cy.cause_detail_303d?p_cause_grou

p_id=885. In addition, no Total Maximum Daily Loads (TMDL) have been developed 

for copper 8-quinolinolate, based on information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation.tmdl_pollutant_detail?p_pollutant_gr

oup_id=885&p_pollutant_group_name=PESTICIDES. More information on impaired 

water bodies and TMDLs can be found at http://www.epa.gov/owow/tmdl/. The Agency 

invites submission of water quality data for this pesticide. To the extent possible, data 

should conform to the quality standards in Appendix A of the OPP Standard Operating 

Procedure: Inclusion of Impaired Water Body and Other Water Quality Data in OPP’s 

Registration Review Risk Assessment and Management Process (see: 

http://www.epa.gov/oppsrrd1/registration_review/water_quality_sop.htm) in order to 

ensure they can be used quantitatively or qualitatively in pesticide risk assessments. 

Environmental Justice 

EPA seeks to achieve environmental justice, the fair treatment and meaningful 

involvement of all people, regardless of race, color, national origin, or income, in the 

development, implementation, and enforcement of environmental laws, regulations, and 

policies. To help address potential environmental justice issues, the Agency seeks 

information on any groups or segments of the population who, as a result of their 

location, cultural practices, or other factors, may have atypical, unusually high exposure 

to copper 8-quinolinolate compared to the general population. Please comment if you are 

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aware of any sub-populations that may have atypical, unusually high exposure compared 

to the general population. 

Structure Activity Relationships 

EPA must rely upon information of appropriate quality and reliability for each 

decision made by the Agency. In the Office of Pesticide Programs (OPP), the evaluation 

process for a pesticide chemical traditionally begins with the applicant’s submission of a 

set of studies conducted with the specific pesticide chemical of interest. The use of the 

results of such testing (measured data) is a logical, scientifically rigorous process that 

identifies the physical, chemical, and environmental fate properties of the pesticide, as 

well as the dose and endpoints at which an adverse effect can occur in various animal 

species. 

Today, there is significant interest in alternative techniques, i.e., techniques other 

than data generation that could significantly inform the Agency’s decision-making 

process. Recently, OPP has made increasing use of structure activity relationship (SAR) 

as part of its regulatory decision-making process. In the SAR process, a chemical's 

molecular structure is compared to that of other chemicals for which data are available. 

These structural similarities are then used to make predictive judgments about a 

chemical’s physical, chemical, and biological properties. Thus, the chemical’s physical, 

chemical, and biological properties are a function of (or directly related to) the chemical’s 

molecular structure. Quantitative SAR is referred to as QSAR. To develop a QSAR, a 

selected set of measured data on a single physical, chemical, or biological property is 

used to derive a model (an equation) to predict the value of that property. 

 Since SAR assessments and QSAR modeling are another set of tools that are 

available to Agency scientists, OPP has begun a process shift that envisions shifting from 

the current study-by-study approach to an approach in which the use of predicted data, 

generated using validated models, is considered along with information from open 

literature and studies specifically generated under Part 161 requirements. All relevant 

information would be considered as part of a weight-of-the-evidence evaluation. 

At this time, EPA believes that for certain endpoints, especially physical/chemical 

and fate properties, that SAR and QSAR might be effectively utilized to fulfill these data 

requirements for many antimicrobial pesticide chemicals. When considering biological 

properties, at this time, EPA believes that SAR and QSAR can be most effectively 

utilized in the evaluation of chemicals that exhibit lower toxicity for human health and/or 

ecotoxicity parameters. This is appropriate because the risk assessment for lower toxicity 

chemicals can be stream-lined, i.e., a screening-level assessment procedure rather than 

multiple tiers of assessments with progressively more data requirements. 

If stakeholders believe that submission of predicted data can fulfill one of the data 

needs for copper 8-quinolinolate, then the Agency invites submission of this information. 

The submitter would be expected to supply a rationale describing the utility of the 

information and provide documentation on the scientific validity of the information. The 

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determination that the predicted data fulfills the data requirement would be at the sole 

discretion of the Agency. Pre-submission consultation with the Agency is encouraged. 

Endocrine Disruptor Screening Program 

As required under FFDCA section 408(p), EPA has developed the Endocrine 

Disruptor Screening Program (EDSP) to determine whether certain substances (including 

pesticide active and other ingredients) may have an effect in humans or wildlife similar to 

an effect produced by a “naturally occurring estrogen, or other such endocrine effects as 

the Administrator may designate.” The EDSP employs a two-tiered approach to making 

the statutorily required determinations. Tier 1 consists of a battery of 11 screening assays 

to identify the potential of a chemical substance to interact with the estrogen, androgen, 

or thyroid (E, A, or T) hormonal systems. Chemicals that go through Tier 1 screening 

and are found to have the potential to interact with E, A, or T hormonal systems will 

proceed to the next stage of the EDSP where EPA will determine which, if any, of the 

Tier 2 tests are necessary based on the available data. Tier 2 testing is designed to 

identify any adverse endocrine related effects caused by the substance, and establish a 

dose-response relationship between the dose and the E, A, or T effect. 

Between October 2009 and February 2010, EPA issued test orders/data call-ins 

for the first group of 67 chemicals, which contains 58 pesticide active ingredients and 9 

inert ingredients. This list of chemicals was selected based on the potential for human 

exposure through pathways such as food and water, residential activity, and certain postapplication agricultural scenarios. This list should not be construed as a list of known or 

likely endocrine disruptors. 

Copper 8-quinolinolate is not among the group of 58 pesticide active ingredients 

on the initial list to be screened under the EDSP. Under FFDCA sec. 408(p) the Agency 

must screen all pesticide chemicals. Accordingly, EPA anticipates issuing future EDSP 

test orders/data call-ins for Registration Review cases, including those for which EPA has 

already opened a Registration Review docket for a pesticide active ingredient. 

For further information on the status of the EDSP, the policies and procedures, the 

list of 67 chemicals, the test guidelines and the Tier 1 screening battery, please visit our 

website: http://www.epa.gov/endo/. 

Additional Information 

Stakeholders are also specifically asked to provide available information and data 

that will assist the Agency in refining the risk assessments. The Agency is interested in 

receiving the following information. 

1. Confirmation on the following label information: 

a. Sites of application 

b. Formulations 

c. Application methods and equipment 

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d. Maximum application rates 

e. Frequency of application, application intervals and maximum 

number of applications 

f. Geographic limitations on use 

2. Use or potential use distribution 

3. Use history 

4. Usage/use information for non-agricultural uses (e.g., materials 

preservation) 

5. Typical application interval 

6. State or local use restrictions 

7. Ecological incidents (non-target plant damage and avian, fish, 

reptilian, amphibian and mammalian mortalities) not already reported 

to the Agency 

8. Monitoring data 

9. Structure Activity Relationships 

Next Steps: 

After the 60-day comment period closes, the Agency will review and respond to 

any comments received in a timely manner, and then issue a Final Work Plan for copper 

8-quinolinolate. 

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II. FACT SHEET 

Background Information

 Chemical Name: Copper, bis(8-quinolinolato-N1,O8)- 

 Common Names: Copper 8-quinolinolate and oxine-copper 

 Trade and Other Names: Copper 8, Copper quinolinolate, Copper-8-

hydroxyquinoline 

 Registration review case number: 5118 

 PC Code: 024002 

 CAS#: 10380-28-6 

 Technical Registrants: Osmose Inc. and Tanabe U.S.A. Inc. 

 First approved for use in a registered product: 1956 

 There are 29 registered products that contain copper 8-quinolinolate as an active 

ingredient: 2 manufacturing use products and 27 end use products 

 Antimicrobials Division Chemical Review Manager (CRM): Rebecca von dem 

Hagen; vondem-hagen.rebecca@epa.gov 

 Antimicrobials Division Product Manager (PM): Jacqueline CampbellMcFarlane, campbell-mcfarlane.jacqueline@epa.gov

Chemical Structure:

 

Use & Usage Information

Type of Pesticide: Algaecide, Bacteriocide/Bacteriostat, Fungicide, Insecticide, 

Microbicide, Repellent or Feeding Depressant 

Use Sites: 

Materials Preservatives

Military/Industrial Textiles, Industrial Cotton, Industrial Fabrics, Webbing, Rope, 

Canvas, Leather, Kraft paper, Paperboard, Adhesives, Paints 

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Wood Preservatives

Wood used in Greenhouse Premises, Equipment and Containers (indirect food 

contact), Log Homes, Shingle Roofs, Siding, Fences, Decks, Furniture, 

Playground Equipment, 

Sills and Baseboards, Structural Building Lumber 

 

Food handling/storage establishments, premises and equipment

Potato Processing, Storage and Transportation Facilities 

Recent Regulatory Actions

In September 2007, the EPA published a Reregistration Eligibility Decision 

(RED) for copper 8-quinolinolate. As part of the Reregistration process, the Agency 

issued a DCI in June 2010. In response to the product specific DCI, the Agency 

anticipates receiving updated labels within 9 months of the date the registrant receives the 

DCI. The copper 8-quinolinolate RED can be viewed at http://www.regulations.gov in 

docket number EPA-HQ-OPP-2007-0556. 

Human Health Risk Assessment Status

 

 The Agency does not anticipate requiring additional human health data for copper 

8-quinolinolate for this registration review. 

Further human health information is available in the document titled “Human 

Health Effects Data for the Copper 8-quinolinolate Registration Review Decision,” dated 

August 30, 2010. 

Product Chemistry Database Status

All product chemistry data requirements have been fulfilled for copper 8-

quinolinolate. Therefore, the Agency does not anticipate requiring any additional product 

chemistry data for this registration review. 

For further information please refer to the Summary of Product Chemistry, 

Environmental Fate, and Ecotoxicity Data for the Copper 8-quinolinolate Registration 

Review Decision Document, dated July 30, 2010. 

Environmental Fate & Ecological Risk Assessment Status

The Agency does not anticipate requiring additional environmental fate and 

ecological risk data for copper 8-quinolinolate for this registration review. 

 The Agency has not conducted a risk assessment that supports a complete 

endangered species determination for copper 8-quinolinolate. The ecological risk 

assessment planned during registration review will allow the Agency to determine 

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whether copper 8-quinolinolate use has “no effect” or “may affect” federally listed 

threatened or endangered species (listed species) or their designated critical habitats. 

When an assessment concludes that a pesticide’s use “may affect” a listed species or its 

designated critical habitat, the Agency will consult with the U.S. Fish and Wildlife 

Service and/or National Marine Fisheries Services (the Services), as appropriate. 

Further information and detailed justification for the studies that are expected to 

be required are available in the document titled, Summary of Product Chemistry, 

Environmental Fate, and Ecotoxicity Data for the Copper 8-quinolinolate Registration 

Review Decision Document, dated July 26, 2010. 

Tolerances 

Copper 8-quinolinolate is cleared by the U.S. Food and Drug Administration 

(FDA) as an indirect food additive for use as a component in food packaging adhesives 

[21 CFR § 175.105(c)]; in paper and paperboard in contact with aqueous and fatty foods 

(21 CFR § 176.170); in paper and paperboard in contact with dry foods (21 CFR § 

176.180); and to preserve wooden articles intended for use in packaging, transporting, or 

holding raw agricultural products [21 CFR 178.3800(b)]. 

There are no tolerances or exemptions from tolerances associated with the active 

ingredient copper 8-quinolinolate. 

Data Call-In Status

 

Generic and product specific DCIs were issued for copper 8-quinolinolate in June 

2010 in connection with reregistration. 

Labels 

There are 29 registered products that contain copper 8-quinolinolate. The EPA 

registration numbers are provided in Table 1 below. For future reference, during 

registration review a list of product registration numbers will be included in the docket. 

Product registration labels may be obtained from the Pesticide Product Label System 

(PPLS) website at: http://oaspub.epa.gov/pestlabl/ppls.home. 

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Table 1. Registered Products Containing Copper 8-quinolinolate

Registration # Registration Name Company Name Formulation 

Type 

% of Active 

Ingredient 

707-302 Cunilate 2002 Rohm & Haas Co Flowable 

Concentrate 10 

1022-476 Chapman PQ-8 IBC Manufacturing Co Soluble 

Concentrate 5.4 

1022-489 PQ-56 IBC Manufacturing Co Soluble 

Concentrate 10 

1022-490 PQ-57 IBC Manufacturing Co Soluble 

Concentrate 5 

1022-491 PQ-15 RTU Clear Wood 

Preservative IBC Manufacturing Co Ready-to-Use Solution 0.25 

1022-492 PQ-20 IBC Manufacturing Co Soluble 

Concentrate 3.75 

1022-493 PQ-15 IBC Manufacturing Co Soluble 

Concentrate 1.38 

1022-503 PQ-7 IBC Manufacturing Co Soluble 

Concentrate 3.24 

1022-504 PQ-56 RTU IBC Manufacturing Co Ready-to-Use 

Solution 0.8 

1022-505 PQ-20 R-T-U Wood 

Preservative IBC Manufacturing Co Ready-to-Use Solution 0.25 

1022-514 Woodguard-Oil Based 

Wood Preservative IBC Manufacturing Co Ready-to-Use Solution 0.675 

2829-42 Socci No. 3500-WP Rohm And Haas 

Company 

Soluble 

Concentrate 10 

2829-44 Cunilate 2174-NO Rohm And Haas 

Company 

Ready-to-Use 

Solution 10 

2829-49 Socci No. 3500 Rohm And Haas 

Company 

Soluble 

Concentrate 10 

2829-112 Cunilate 2419-75 Rohm And Haas 

Company 

Emulsifiable 

Concentrate 7.5 

2829-135 Nytek 10WP Rohm And Haas 

Company 

Wettable 

Powder 10 

2829-136 Nytek 10 Rohm And Haas 

Company 

Soluble 

Concentrate 10 

2829-137 Nytek WD Rohm And Haas 

Company 

Emulsifiable 

Concentrate 10 

3008-91 ORD-X378 Osmose Inc. Ready-to-Use 34.18 

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Formulation % of Active Registration # Registration Name Company Name Type Ingredient 

Solution 

3008-93 Copper 8-Quinolinolate Osmose Inc. Technical 

Chemical 96 

10829-8 Copper 8-Quinolinolate Tanabe U.S.A. Inc. Technical 

Chemical 96 

60061-17 Woodtreat C8 Concentrate Kop-Coat, Inc. Soluble 

Concentrate 1.2 

60061-18 Woodtreat C8 Ready To 

Use Kop-Coat, Inc. Ready-to-Use Solution 0.25 

60061-22 

Woodtreat C81 Ready To 

Use Water Repellent 

Fungicide 

Kop-Coat, Inc. Ready-to-Use 

Solution 1 

75341-14 ORD-X240 Osmose Utilities 

Services, Inc. 

Ready-to-Use 

Solution .3 

81819-1 Q8 Log Oil CTA Products Group Ready-to-Use 

Solution 0.675 

83515-1 A4 James Hardie Building 

Products, Inc. 

Formulation 

Intermediate 98 

84397-1 Moldan-10 Environmental RX, Inc. Soluble 

Concentrate 10 

84711-1 Nylate PW Genett Group, Inc. Ready-to-Use 

Solution 0.625 

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III. GLOSSARY of TERMS & ABBREVIATIONS

ai Active Ingredient 

AR Anticipated Residue 

ASTM American Society for Testing and Materials 

AWPA American Wood Preserver’s Association 

CFR Code of Federal Regulations 

cPAD Chronic Population Adjusted Dose 

CSF Confidential Statement of Formula 

CSFII USDA Continuing Surveys for Food Intake by Individuals 

DCI Data Call-In 

DEEM Dietary Exposure Evaluation Model 

DFR Dislodgeable Foliar Residue 

DNT Developmental Neurotoxicity 

DWLOC Drinking Water Level of Comparison 

EC Emulsifiable Concentrate Formulation 

EDWC Estimated Drinking Water Concentration 

EEC Estimated Environmental Concentration 

EPA Environmental Protection Agency 

EUP End-Use Product 

FDA Food and Drug Administration 

FIFRA Federal Insecticide, Fungicide, and Rodenticide Act 

FFDCA Federal Food, Drug, and Cosmetic Act 

FQPA Food Quality Protection Act 

FOB Functional Observation Battery 

GENEEC Tier I Surface Water Computer Model 

IR Index Reservoir 

LC50 Median Lethal Concentration. A statistically derived concentration of a 

substance that can be expected to cause death in 50% of test animals. It is 

usually expressed as the weight of substance per weight or volume of water, air 

or feed, e.g., mg/l, mg/kg or ppm. 

LD50 Median Lethal Dose. A statistically derived single dose that can be expected to 

cause death in 50% of the test animals when administered by the route indicated 

(oral, dermal, inhalation). It is expressed as a weight of substance per unit 

weight of animal, e.g., mg/kg. 

LOC Level of Concern 

LOAEL Lowest Observed Adverse Effect Level 

μg/g Micrograms Per Gram 

μg/L Micrograms Per Liter 

mg/kg/day Milligram Per Kilogram Per Day 

mg/L Milligrams Per Liter 

MOE Margin of Exposure 

MRID Master Record Identification (number). EPA's system of recording and tracking 

submitted studies. 

MUP Manufacturing-Use Product 

NA Not Applicable 

NAWQA USGS National Ambient Water Quality Assessment 

NPDES National Pollutant Discharge Elimination System 

NR Not Required 

NOAEL No Observed Adverse Effect Level 

OPP EPA Office of Pesticide Programs 

OPPTS EPA Office of Prevention, Pesticides and Toxic Substances 

PAD Population Adjusted Dose 

PAIRA Pure Active Ingredient Radiolabelled 

PCA Percent Crop Area 

PDP USDA Pesticide Data Program 

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PHED Pesticide Handler's Exposure Data 

PHI Preharvest Interval 

ppb Parts Per Billion 

PPE Personal Protective Equipment 

ppm Parts Per Million 

PRZM/EXAMS Tier II Surface Water Computer Model 

Q1* The Carcinogenic Potential of a Compound, Quantified by the EPA's Cancer 

Risk Model 

RAC Raw Agriculture Commodity 

RED Reregistration Eligibility Decision 

REI Restricted Entry Interval 

RfD Reference Dose 

RQ Risk Quotient 

SCI-GROW Tier I Ground Water Computer Model 

SAP Science Advisory Panel 

SF Safety Factor 

SLN Special Local Need (Registrations Under Section 24©) of FIFRA) 

TGAI Technical Grade Active Ingredient 

TEP Typical End-Use Product 

USDA United States Department of Agriculture 

UF Uncertainty Factor 

WPS Worker Protection Standard 
Docket Number: EPA-HQ-OPP-2010-0454 

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IV. APPENDIX A

Use Patterns for Copper 8-quinolinolate 

Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use L

Materials preservatives 

Soluble Concentrate: 1022-493 1022-492 2829-42 2829-49 2829-135 60061-17 

Textiles, Canvas, Burlap, Rope, Twine, Cotton Duck, Cotton Webbing, Twill and Cardboard 

Ready to Use: 60061-22 60061-18 

Dip, spray, or flow coat

Water Based Solution:Dilute 1:20 to 1:50 in water for .25% to .75% of copper depending upon severity of service. Immersion: Immerse completely the object to be treated in the solution for 15 to 30 seconds. Allow sufficient time for the treated objects to dry prior to any further processing. For objects that cannot be immersed, liberal applications by flooding, rolling or brushing. Oil Based Solution: 1 volume to 5 volumes of petroleum oil (or other organic solvent) dip for 15 seconds to 10 minutes depending on the tightness of the weave. 

Not stated 

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Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use L

Adhesives and Glues Soluble 

Concentrate: 10829-8 

Dispersing in Solvent or Aqueous Systems 

It is recommended that levels from 0.015 to 0.1% by weight of copper 8- quinolinolate be used for the protection of adhesives and glues based on the weight of the finished product, to protect the product while in the can. 

Not stated

Paints Soluble 

Concentrate: 10829-8 

Dispersing in Solvent or Aqueous Systems 

Copper 8- quinolinolate should be used at levels of from 0.1%to1.0% based on the volume of the finished product. The median level of 0.5% to 0.75% is most generally used and has remained free from mold after two years under conditions where ordinary paint becomes contaminated after 60 days of exposure. 

Not stated

Soluble Concentrate 1022-490 1022-489 2829-44 707-302

Brush, Spray or Short Dip 

Dilute 1:20 to 1:50 for .25% to .75% of copper depending upon severity of service. 

Paper Products Not stated

Emulsifiable Applied at the Incorporate a minimum of Not stated 

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Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use L

Concentrate 2829-112 

Size Press 3.2% of product by weight 

into the sheet to deposit 0.45% copper as metal. 

Cement, Pulp and Paper Ingredients 

Formulation Intermediate 83515-1 

Not stated For formulation into enduse products as an additive 

to control mold and mildew on cement and/or pulp paper ingredients in such products. 

Not for use in food and paper coating. This product is a co

designed to be used facility where dosincontrolled. 

Adhesives, Kraft Paper, Paints, Paperboard and Textiles Adhesives, Kraft Paper, Paints, Paperboard and Textiles (Continued) 

Soluble Concentrate 84397-1 Soluble Concentrate 84397-1 

Spray and Dip Spray and Dip 

Paper and Paperboard Products: Use a minimum level of 5.5% of this product by weight (equivalent to 0.1% Cu) for incorporation into the product. This rate is recommended to control mold, mildew and fungal degradation. Kraft Papers are treated by dip and dry methods. Paperboard and heavy Krafts are treated by adding this product to the pulp followed by thorough mixing of the pulp and this 

Not stated Not stated 

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Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use L

Adhesives, Kraft paper, Paints, Paperboard and Textiles (Continued) 

Soluble Concentrate 84397-1 

Spray and Dip 

product. Military Shoe Counter Specifications: 0.5% to 0.10% Cu. Textiles: Use a minimum level of 8.3% of this product by weight (equivalent to 0.15% Cu) for control of textiles mold, mildew and fungal degradation. Water repellents can be incorporated with this product into the textiles. Before incorporating these products, check to be sure that the forms flakes, sludges, jells, oily films or layers, or other precipitates. If these are observed, the mixture of this product with the water repellant should not be used. Adhesives: For dried film protection of adhesives and 

 Not stated 

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Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use L

glues, use this product at 2.8% to 5.8% by weight of the dry material. Synthetic emulsions (ethylene-vinyl acetate) and naturally derived starches, dextrins and animal glues are protected from mildew by a thorough mixing of this product in the final compounding of the adhesive. Paints: Add this product to interior latex paints at rates ranging from 1% to 10% by volume of paint. Optimum protection of the paint film from mold and mildew are obtained with close levels of 7.5% (v/v). Spray Applications:Dilute this product with water by mixing 1 part of this product with between 15 and 60 parts water. Apply as a coarse spray to thoroughly cover the wood 

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Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use L

Adhesives, Kraft paper, Paints, Paperboard and Textiles (Continued) 

Soluble Concentrate 84397-1 

Spray and Dip 

surface. Collect any solution that runs off from the treated wood so it can be re-used. One gallon of the diluted spray solution will treat 150 to 250 sq. ft. of wood, depending on the wood type. Dip Applications: Dilute this product with water by mixing 1 part of this product between 15 and 40 parts of water. Ensure that the placement of the wood allows all wood surfaces to be completely covered in treatment solution. Allow the wood to be immersed in the equipment, allow any treatment solution to drip back into the equipment for re-use. Five to ten gallons of the diluted dipping solution will treat 1,000 board feet. 

Not stated 

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Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use L

Paper and Paperboard (Wallboard), Brown Paper Mills, Sheet for Corrugated Board, Kraft Paper and Newsprint 

Ready-to-Use 84711-1 

Spray or Dip Spray or dip Kraft Paper or 

Paperboard (Wallboard) with this product, then allow the product to dry. 

Do not apply this prcontact workers or odirectly or through dhandlers may be in application. This product is only applications. 

Wood preservativesWood Used in Above Ground Service and Ground Contact Service 

Soluble Concentrate 1022-489 1022-490 2829-137 

Dip, Spray or Flow Coat 

Above Ground Service: For mild conditions, apply liberally by brush or spray at 1:20 use dilution in water. For severe conditions, dip for a minimum of three minutes. For Ground contact Service: For mild conditions, apply by dipping for 12 – 48 hours at a 1:10 dilution in water. For Severe Service: use a 1:4 use dilution in water and dip for 12-48 hours. 

Not stated 

Wood Items: Used in Soluble Dip or It is recommended that None stated 

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Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use L

Packaging, Transporting, or Holding Agricultural Products; Wooden Decking for Trucks, Trailers, Railroad Cars, Patios, Beverage Cases, Interior Plywood and Lumber Walls, Ceilings of Vans and Refrigerator Van Bodies, Rail Beams, Ladders, Interior Bolds of Boats, Framing Lumber in Floors and Walls of Shower Rooms, Wood Used Around Swimming Pools (and Roofs), Wood Used for Construction of Food Processing Establishments and Warehouses 

Concentrate 2829-136 

Pressure Treatment 

levels of 0.15 to 1.0% by weight of the product be used in the protection of adhesives and glues, based on the weight of the finished product. This product should be incorporated at levels 5 to 10% based on the volume of paint. The medium level of 7.5% is most generally used. 

Wood Preservation Shingles, Siding, Millwork, Timber, Furniture, Poles, Posts, Decks, Greenhouse Items, Playground Equipment, Window Sills and Frames, Fascia Boards, Log Homes, Roofs, Old 

Soluble concentrate: 1022-476 1022-503 

Dip, Spray, or Flow Coat 

Base Strength: 1 gallon to 150-250 gallons of water. Stronger than Base Strength: 1 gallon to 30-50 gallons of water. 

None stated

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Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use L

Weathered Wood and New Porous Wood 

Ready to use: 1022-505 1022-504 1022-491 1022-514 

The most effective treatment is obtained with pressure treating or extended soaking where deep penetration and high absorption are obtained. With spraying or brushing multiple flowing coats should be applied. 

Soluble concentrate: 1022-476 1022-503 

Base Strength: 1 gallon to 150-250 gallons of water. Stronger than Base Strength: 1 gallon to 30-50 gallons of water. 

Wood used in Greenhouse Premises Equipment and Containers (indirect food contact) Wood in Contact with Fruit, Vegetables and other Food Stuffs Including Boxes and Bins, Mushrooms Trays, Pallets, Nursery Trays, Flats, Stakes and Fences Ready to Use: 

1022-505 1022-504 1022-491 1022-514 

Dip, Spray, or Flow Coat 

The most effective treatment is obtained with pressure treating or extended soaking where deep penetration and high absorption are obtained. With spraying or brushing multiple flowing coats should be applied 

None stated 

Lumber (2 inch thick or less) Sapstain Control 

Soluble Concentrate: 

Dip, Spray, or Flow Coat 

Base strength: 1 gallon to 150-250 gallons 

None stated

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Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use L

1022-476 1022-503 Ready to use: 3008-91 

of water Stronger than Base Strength: 1 gallon to 30-50 gallons of water 

Wood Preservatives Technical 

Chemical 3008-93 

Not Stated This product is for the 

formulation of wood preservatives and in the production of porous cement surfaces. 

This product may bproducts for any addthe label if the formU.S. EPA data submregarding support o

In-Service Poles, Posts and Other Timber Members 

Ready-to-Use 75341-14 

Brush, Trowel or Pump 

External Treatment: Apply to a thickness of 1/16” on poles or timber. Typical pole application is from 3” above to 18” below ground line and lower where deeper decay is suspected. Application on poles to be restored should extend the length of 

Not for household u

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Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use L

wrap-around type repair systems. Wrap area with water-proof bandage, OSMOSHIELD. Internal Treatment: For control of internal decay in poles and other timbers, holes may be drilled in areas of the poles or timber where protection is required. Fill drilled holes, decay pockets, and voids using a grease gun or other pressurized applicator. Plug application holes with secure- fitting dowels. 

Water Repellent Wood Preservative 

Ready-to-Use 81819-1 

Spray, Brush or Roller 

Application: Surfaces to be treated should be bleached or acid cleaned and free of all loose debris. For maximum penetration and fastest drying apply to dry wood. This product can be applied to damp wood but expect reduced performance. 

Do not apply to nonsurfaces that prevenpenetration. 

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Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use L

Water Repellent Wood Preservative (Continued) 

Ready-to-Use 81819-1 

Spray, Brush or Roller 

Apply one coat of this product liberally to the surface to be treated by wetting down the surface as follows: Spray- Using pump-up garden type spray equipment set the sprayer nozzle to deliver a coarse, low pressure spray, and backrush as needed. Roller or Brush applications are suitable if applied to the point of refusal. Spray applications are preferred when possible. 

Do not apply to nonsurfaces that prevenpenetration. 

Above Ground Uses: Decking for Trucks, Patios, Swimming Pools, Ladders, Boat Interiors, Gypsum Board or Panelings in Shower Rooms 

Soluble Concentrate 84397-1 

Dip or Paint Dilute this product as a 

1:10 dilution in water. Dip the wood to be treated in this product for three minutes. Alternatively, the wood can be painted using 1 gallon of a 1:10 dilution of this product per 450 sq. 

Not stated 

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Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use L

ft. of wood. 

Above Ground Uses: Decking for Trucks, Patios, Swimming Pools, Ladders, Boat Interiors, Gypsum Board or Panelings in Shower Rooms (Continued) 

Ready-to-Use 84711-1 Ready-to-Use 84711-1 

Dip, Spray or Paint Dip, Spray or Paint 

Wood: Wood can either be sprayed or dipped in this product for three minutes. Alternatively the wood can be painted using 1 gallon of this product per 450 sq. ft. of wood. Spray Applications:Apply this product as a coarse spray to thoroughly cover the wood surface. Collect any solution that runs off from treated wood so it can re-used. One gallon of the diluted spray solution will treat 150-250 sq. ft. of wood, depending upon wood type. Dip Applications: Ensure that the placement of wood in a dip tank containing this product allows all wood surfaces to be completely covered by the 

Do not apply this prcontact workers or odirectly or through dhandlers may be in application. Do not apply this prcontact workers or odirectly or through dhandlers may be in application. 

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Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use L

treatment solution. Allow the wood immersed in the treatment solution for a minimum of three minutes. After removing the wood from the dipping equipment, allow any treatment solution to drip back into the equipment for re-use. Five to ten gallons of the dipping solution will treat 1,000 board feet. 

Food handling/storage establishments, premises and equipment Potato processing, storage and transportation facilities 

Soluble Concentrate: 1022-489  1022-490  75675-1 

Spray Applicator 

Pre-clean area and allow to air dry before applying. Dilute 1:100-200 in water with careful agitation to lessen foaming. Spray all surfaces with a non-mist type nozzle set at approx. 20 psi. 

Although not photoDO NOT treat the p