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| x | ANNUAL      REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF      1934 |
|---|------------------------------------------------------------------------------------------------|

| ¨ | TRANSITION      REPORT PURSUANT TO SECTIONS 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF      1934 |
|--------|-----------------------------------------------------------------------------------------------------|

| Delaware                                                                |   | 22-2845714                                    |
|-------------------------------------------------------------------------|--------|-----------------------------------------------|
| (State      or other jurisdiction ofincorporation      or organization) |   | (I.R.S.      EmployerIdentification      No.) |

|                                          |   |                                      |
|-----------------------------------------------|--------|-------------------------------------------|
| Title      of Class                           |   | Name      of Exchange on Which Registered |
| Common      Stock, $0.025 par value per share |   | NASDAQ      Global Market                 |

|                                                      |   |                                                        |
|-----------------------------------------------------------|--------|-------------------------------------------------------------|
| Large accelerated filer        ¨ |   | Accelerated filer        x                   |
| Non-accelerated filer        ¨        |   | Smaller reporting company        ¨ |
| (Do      not check if smaller reporting company)          |   |                                                        |

SIGNATURES

| NEUROGEN      CORPORATION                                                                                 |
|-----------------------------------------------------------------------------------------------------------|
|                                                                                                      |
| By: /s/ STEPHEN R.      DAVIS                                                                             |
|                                                                                                      |
| Stephen      R. DavisPresident      and Chief Executive OfficerDated:       April      4, 2008  |

| SIGNATURE                                                                                                                                                                                      |   | TITLE                                                                                                     |   | DATE                     |
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|-----------------------------------------------------------------------------------------------------------|--------|--------------------------|
|                                                                                                                                                                                           |   |                                                                                                      |   |                     |
|                                                                                                                                                                                           |   |                                                                                                      |   |                     |
| *                                                                                                                                                                                              |   |                                                                                                      |   |                     |
| Craig      Saxton                                                                                                                                                                              |   | Chairman      of the Board and Director                                                                   |   | April      4, 2008       |
|                                                                                                                                                                                           |   |                                                                                                      |   |                     |
| /s/      STEPHEN R. DAVIS                                                                                                                                                                      |   |                                                                                                      |   |                     |
| Stephen      R. Davis                                                                                                                                                                          |   | President      and Chief Executive Officer and Director (Principal Financial and      Accounting Officer) |   | April      4, 2008       |
|                                                                                                                                                                                           |   |                                                                                                      |   |                     |
| *                                                                                                                                                                                              |   |                                                                                                      |   |                     |
|  Felix      Baker                             |   | Director                                                                                                  |   | April      4, 2008       |
|                                                                                                                                                                                           |   |                                                                                                      |   |                     |
| *                                                                                                                                                                                         |   |                                                                                                      |   |                     |
| William      H. Koster                                                                                                                                                                         |   | Director                                                                                                  |   |  April      4, 2008 |
|                                                                                                                                                                                           |   |                                                                                                      |   |                     |
| *                                                                                                                                                                                              |   |                                                                                                      |   |                     |
| Julian      C. Baker                                                                                                                                                                           |   | Director                                                                                                  |   | April      4, 2008       |
|                                                                                                                                                                                           |   |                                                                                                      |   |                     |
| *                                                                                                                                                                                              |   |                                                                                                      |   |                     |
| Eran      Broshy                                                                                                                                                                               |   | Director                                                                                                  |   | April      4, 2008       |
|                                                                                                                                                                                           |   |                                                                                                      |   |                     |
| *                                                                                                                                                                                              |   |                                                                                                      |   |                     |
| Stewart      Hen                                                                                                                                                                               |   | Director                                                                                                  |   | April      4, 2008       |
|                                                                                                                                                                                           |   |                                                                                                      |   |                     |
|                                                                                                                                                                                           |   |                                                                                                      |   |                     |
| John      L. LaMattina                                                                                                                                                                         |   | Director                                                                                                  |   | April      4, 2008       |
|                                                                                                                                                                                           |   |                                                                                                      |   |                     |
| *                                                                                                                                                                                              |   |                                                                                                      |   |                     |
| Jonathan      S. Leff                                                                                                                                                                          |   | Director                                                                                                  |   | April      4, 2008       |
|                                                                                                                                                                                           |   |                                                                                                      |   |                     |
| *                                                                                                                                                                                              |   |                                                                                                      |   |                     |
| John      Simon                                                                                                                                                                                |   | Director                                                                                                  |   | April      4, 2008       |
|                                                                                                                                                                                           |   |                                                                                                      |   |                     |
| * By:  /s/      STEPHEN R. DAVIS                                                                                                                                                     |
| Stephen      R. Davis, Attorney-in-Fact                                                                                                                                                        |