Docket Number: EPA-HQ-OPP-2010-0454

www.regulations.gov

United States Chemical Safety September 2010

Environmental Protection and Pollution Prevention

Agency (7510P)



# Copper 8-quinolinolate Summary

Document: Registration ReviewDocket Number: EPA-HQ-OPP-2010-0454

www.regulations.gov



## TABLE OF CONTENTS

Copper 8-quinolinotate

Registration Review Team ............................................................................................... 4

I. PRELIMINARY WORK PLAN – Copper 8-quinolinolate ...................................... 5

II. FACT SHEET ............................................................................................................ 14

III. GLOSSARY OF TERMS & ABBREVIATIONS ................................................. 19

IV. APPENDIX A............................................................................................................ 21

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### Copper 8-quinolinolate

Registration Review Team

Human Health & Environmental Effects

William J. Hazel

Srinivas Gowda

Risk Management

Rebecca von dem Hagen

Lance Wormell

Office of General Counsel

Philip Ross

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### I. PRELIMINARY WORK PLAN – Copper 8-quinolinolate

Introduction

The Food Quality Protection Act (FQPA) of 1996 mandated a re gistration review

program. All pesticides distributed or sold in the United States generally must be

registered by the U.S. Environmental Protec tion Agency (USEPA, EPA, or the Agency),

based on scientific data showing that they will not cause unreasonable risks to human

health or the environment when used as di rected on product labe ling. The registration

review program is intended to make sure that , as the ability to assess risk evolves and as

policies and practices change, all registered pesticides continue to meet the statutory

standard of no unreasonable adverse effects to human health or the environment. Changes

in science, public policy, and pesticide use practices will occur over time. Through the

registration review program, the Agency periodically reevaluate s pesticides to make sure

that as change occurs, products in the mark etplace can be used safely. Information on

this program is provided at http://www.epa.gov/oppsrrd1/ registration_review/

.

The Agency is implementing the registra tion review program pursuant to Section

3(g) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and will review

each registered pesticide every 15 years to de termine whether it continues to meet the

FIFRA standard for registration. The Agency will consider benefits information and data

as required by FIFRA. The public phase of re gistration review begins when the initial

docket is opened for each case. The docket is the Agency’s opportunity to state what it

knows about the pesticide and what additional risk analyses and data or information it

believes are needed to make a registrati on review decision. After reviewing and

responding to comments and data received in the docket during th is initial comment

period, the Agency will develop and commit to a final work plan and schedule for the

registration review of copper 8-quinolinolate.

Copper 8-quinolinolate is registered for use as a wood preserva tive for control of

sapstain, mold and decay in unfinished wood and wood products such as millwork,

siding, decks, outdoor furniture, shingles, structural lumber, boats, decks and baseboards.

Treated wood materials may be used in contact with fruit, vegetables and other foodstuffs

in areas such as greenhouses and greenhous e items, produce picking boxes, mushroom

trays and vegetable stakes. The chemical is also registered for use as a disinfectant to

control potato ring rot in plante rs, seed handling equipment, seed cutters, storage areas

and transportation equipment. Copper 8-qui nolinolate is registered for use in the

manufacture of kraft paper, paperboard, backer board, adhesives, and paints as a fungicide

and mildewicide. In additi on, this chemical is register ed for use as a material

preservative to control mold and mildew on industrial and military textiles such as

canvas, burlap, rope, leather and nets (non-aquatic uses only).

Copper 8-quinolinolate (PC Code 024002) was first registered in the United

States in 1956 and currently there are 29 registrations, 2 manufacturing use products

(MUPs) and 27 end use products (EUPs). EPA previously reevaluated copper 8-

quinolinolate as part of the Copper Salts Reregistration case, Case Number 4026.

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### Because copper 8-quinolinolate is toxicolo gically unique from elemental copper and,

therefore, potentially subject to different risk assessmen ts, data needs, and labeling

changes, EPA completed a separate RED fo r copper 8-quinolinolate in September 2007.

To minimize future confusion betwee n copper 8-quinolinolate and other copper

compounds, the Agency created a new Re gistration Review case for copper-8-

quinolinolate, Case Number 5118. As part of the Reregistration pro cess, a data call-in

(DCI) was issued in June 2010. The copper 8-quinolinolate RED can be viewed at

http://www.regulations.gov in docket number EPA-HQ-OPP-2007-0556.

Risk Assessment Status & Anticipa ted Data Needs

Human Health Risk Assessment Status and Anticipated Data Needs

The Agency has reviewed all the availa ble information on toxicology and human

exposure regarding copper 8-qui nolinolate. As a result of this review, EPA confirmed

that the data being called-in through the r ecently issued Reregistration DCI are still

needed. The Agency does not anticipate the ne ed to require any other human health data

for copper 8-quinolinolate for this registration review.

Further human health information is av ailable in the document titled “Human

Health Effects Data for Copper 8-quinolinol ate Registration Revi ew Decision,” dated

August 30, 2010.

Dietary and Drinking Water Assessment

Dietary Exposure

Chronic dietary exposure and risk we re assessed in the 2007 RED for copper 8-

quinolinolate due to copper 8-quinolinolate’ s potential to migrate into food through

pulp/paper and adhesives. EPA will update the chronic dietary risk assessment used to

support the 2007 RED as appropriate including an assessment of risk associated with the

migration of copper 8-quinolinolate from treat ed wood into food. Information to assess

the migration from treated wood into food wa s not available at th e time of the RED and

those data were required through a 2010 Re registration DCI. The Agency does not

anticipate conducting an acute di etary risk assessment because, as stated in the 2007

RED, copper 8-quinolinolate does not cause adverse systemic effects resulting from a

single dose.

Drinking Water Exposure

The need for a drinking water exposure assessment will be determined upon

submission and review of leaching data be ing called in through the 2010 Reregistration

DCI.

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### Tolerances

Copper 8-quinolinolate is cleared by the U.S. Food and Drug Administration

(FDA) as an indirect food additive for us e as a component in f ood packaging adhesives

[21 CFR § 175.105(c)]; in paper and paperboard in contact wi th aqueous and fatty foods

(21 CFR § 176.170); in paper and paperboard in contact with dry foods (21 CFR §

176.180); and to preserve wooden articles intended for use in packaging, transporting, or

holding raw agricultural pr oducts [21 CFR 178.3800(b)].

There are no EPA established tolerances or exemptions from to lerances associated

with the active ingredient copper 8-quinolinolate.

Aggregate and Cumulative Exposure

In examining aggregate exposure, EP A takes into account the available and

reliable information concerning exposures to pesticide residues in food and drinking

water, as well as non-occupationa l pesticide exposures. Base d on current use patterns, an

aggregate risk assessment is anticipated as being needed for c opper 8-quinolinolate for

dietary (food) and residential exposure. The need for a drinking water exposure

assessment and the inclusion of drinking wate r exposure in the aggregate assessment will

be determined by the review of leac hing data being calle d in through the 2010

Reregistration DCI.

Section 40(b)(2)(D)(v) of FFDCA requi res that, when considering whether to

establish, modify, or revoke a tolerance, th e Agency considers “available information”

concerning the cumulative effects of a part icular pesticide’s residues and “other

substances that have a common mechanism of toxicity.” EPA has not yet determined

whether copper 8-quinolinolate has a common mechanism with other compounds;

consequently a cumulative assessment will not be performed at this time.

Occupational and Residen tial Assessm ent and Risk

An occupational and/or residential expos ure assessment is required for an active

ingredient if (1) certain toxico logical criteria are triggered and (2) there is potential

exposure to handlers (mixers, loaders, applicat ors, etc.) during use or to persons entering

treated sites after application is complete. The Agency reviewed all available

information associated with copper 8-quinolin olate and determined that the currently

registered uses of copper 8-quinolinolate may result in both occupational and residential

exposure.

Occupational Exposure

Occupational handler dermal and inhalation scenarios as well as post-application

exposure scenarios were assessed for the 2007 copper 8-quinolinolate RED. All assessed

scenarios were determined not to exceed the Agency’s level of concern except for the

wood preservative scenario. Because the scen arios used to estimate risk from exposure

through wood preservative uses relied on cons ervative assumptions, EPA considered the

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### use eligible for reregistration but requ ired confirmatory data through a 2010

Reregistration DCI. Once these data are recei ved, EPA intends to review the data and

update the wood preservative scenario.

The Agency reviewed the 2007 risk asse ssment and determined that the data

being called in through the 2010 Reregistration DCI are still needed. The Agency does

not anticipate the need to require any additional occupati onal exposure data for copper 8-

quinolinolate for this registration review.

Residential Exposure

Residential handler dermal and inha lation exposure scenarios as well as

residential post-application exposure scen arios were assessed for the 2007 copper 8-

quinolinolate RED. All residential expos ure assessments, both handler and postapplication, were determined not to exceed the Agency’s level of concern. The Agency

reviewed the 2007 risk assessmen t and determined that the data being called in through

the 2010 Reregistration DCI are still needed. The Agency does not anticipate the need to

require any other residential exposure data for copper 8-quino linolate for this registration

review.

Product Chemistry Status and Anticipated Data Needs

All product chemistry data requirements have been fulfilled for copper 8-

quinolinolate. Therefore, the Agency does not anticipate requiring additional product

chemistry data for copper 8-quinolinol ate for this registration review.

For further information please refer to the Summary of Product Chemistry,

Environmental Fate, and Ecotoxicity Data for the Copper 8-quinolinolate Registration

Review Decision Document, dated July 30, 2010.

Environmental Fate and Ecological Risk A ssessment Status and Anticipated Data

Needs

The Agency does not expect to require additional data through the registration

review process. The data being called in as a result of the June 2010 Reregistration DCI

will be evaluated and used to support the regi stration review risk assessments for copper

8-quinolinolate.

Further information and detailed justificat ion for the studies that are expected to

be required are available in the document titled, Summary of Product Chemistry,

Environmental Fate, and Ecotoxicity Data for the Copper 8-quinolinolate Registration

Review Decision Document, dated July 30, 2010.

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### Endangered Species

The Agency has not conducted a risk assessment that supports a complete

endangered species determination for copper 8-quinolinolate. The ecological risk

assessment planned during registration revi ew will allow the Agency to determine

whether use of copper 8-quinolinolate has “no effect” or “may affect” federally listed

threatened or endangered species (listed specie s) or their designated critical habitats.

When an assessment concludes that a pesticid e’s use “may affect” a listed species or its

designated critical habitat, the Agency w ill consult with the U.S. Fish and Wildlife

Service and/or National Marine Fisheries Se rvice (the Services), as appropriate.

Incidents:

Ecological

There are no reported incidents in the Ag ency’s Ecological Incident Information

System (EIIS) involving copper 8-quinolinolat e. The absence of documented incidents

does not necessarily mean that incidents did not occur.

Human Health

A small number of incidents (eight) have been reported that have a likely

association with exposure to end-use products containing copper 8-qui nolinolate. These

occurred in California between 1982 and 2004. The skin and eyes were the primary

routes of exposure and the resulting symptom was irritation. No severe incidents have

been reported as being associated with copper 8-quinolinolate exposure.

Timeline:

EPA has created the following estimated timeline for the completion of the copper

8-quinolinolate registration review:

Anticipated Schedule

Activities Estimated Month/Year

Phase 1: Opening the docket

Open Public Comment Period for Copper 8-quinolinolate Docket September 2010

Close Public Comment Period November 2010

Phase 2: Case Development

Develop Final Work Plan (FWP) February 2011

Open Public Comment Period for Preliminary Risk Assessments June 2013

Close Public Comment Period September 2013

Phase 3: Registration Review Decision

Open Public Comment Period for Propos ed Reg. Review Decision December 2014

Close Public Comment Period March 2015

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### Final Decision and Begin Post-Decision Follow-up 2015

Total (years) 5

Guidance for Respondents:

The public is invited to co mment on EPA’s preliminary registration review work

plan and rationale. The Agency will caref ully consider all comments as well as any

additional information or data provided in a timely manner pr ior to issuing a final work

plan for the copper 8-quinolinol ate registration review case.

Trade Irritants

Through the registration review process, th e Agency intends to solicit information

on trade irritants and, to the extent feasible , take steps toward facilitating irritant

resolution. Growers and other stakeholders are asked to comment on any trade irritant

issues resulting from lack of Maximum Residue Limits (MRLs) or disparities between

U.S. tolerances and MRLs in key export ma rkets, providing as much specificity as

possible regarding the nature of the concern.

Water Quality

Copper 8-quinolinolate is not identified as a cause of impairment for any water

bodies listed as impaired under section 303(d) of the Clean Water Act, based on

information provided at

http://iaspub.epa.gov/tmdl_waters10/attain s_nation_cy.cause_detail_303d? p_cause_grou

p_id=885 . In addition, no Total Maximum Daily Loads (TMDL) have been developed

for copper 8-quinolinolate, base d on information provided at

http://iaspub.epa.gov/tmdl_waters10/attain s_nation.tm dl_pollutant _detail?p_pollutant_gr

oup_id=885&p_pollutant_group_name=PESTICIDES . More information on impaired

water bodies and TMDLs can be found at http://www.epa.gov/owow/tmdl/ . The Agency

invites submission of water quality data for this pesticide. To the extent possible, data

should conform to the quality standards in Appendix A of the OPP Standard Operating

Procedure: Inclusion of Im paired Water Body and Other Water Quality Data in OPP’s

Registration Review Risk A ssessment and Management Process (see:

http://www.epa.gov/oppsrrd1/regist ration_review/water_quality_sop.htm ) in order to

ensure they can be used quantitatively or qualitatively in pesticide risk assessments.

Environmental Justice

EPA seeks to achieve environmental justi ce, the fair treatment and meaningful

involvement of all people, regardless of race, color, national origin, or income, in the

development, implementation, and enforcemen t of environmental laws, regulations, and

policies. To help address potential environmental justice issues, the Agency seeks

information on any groups or segments of the population who, as a result of their

location, cultural practices, or other factor s, may have atypical, unusually high exposure

to copper 8-quinolinolate compared to the ge neral population. Please comment if you are

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### aware of any sub-populations that may have atypical, unusually high exposure compared

to the general population.

Structure Activity Relationships

EPA must rely upon information of appropr iate quality and reliability for each

decision made by the Agency. In the Office of Pesticide Programs (OPP), the evaluation

process for a pesticide chemical traditionally begins with the appli cant’s submission of a

set of studies conducted with th e specific pesticide chemical of interest. The use of the

results of such testing (measured data) is a logical, scientifically rigorous process that

identifies the physical, chemical, and environmen tal fate properties of the pesticide, as

well as the dose and endpoints at which an adverse effect can occur in various animal

species.

Today, there is significant interest in a lternative techniques, i.e., techniques other

than data generation that could significan tly inform the Agency’s decision-making

process. Recently, OPP has made increasing use of structure activity relationship (SAR)

as part of its regulatory d ecision-making process. In the SAR process, a chemical's

molecular structure is compared to that of other chemicals fo r which data are available.

These structural similarities are then us ed to make predictive judgments about a

chemical’s physical, chemical, and biological properties. Thus, the chemical’s physical,

chemical, and biological propertie s are a function of (o r directly related to) the chemical’s

molecular structure. Quantitative SAR is re ferred to as QSAR. To develop a QSAR, a

selected set of measured data on a single phys ical, chemical, or bi ological property is

used to derive a model (an equation) to predict the valu e of that property.

Since SAR assessments and QSAR modeli ng are another set of tools that are

available to Agency scientists, OPP has begun a process shift that envisions shifting from

the current study-by-study appro ach to an approach in which the use of predicted data,

generated using validated models, is cons idered along with information from open

literature and studies specifi cally generated under Part 161 requirements. All relevant

information would be considered as part of a weight-of-the-evidence evaluation.

At this time, EPA believes that for cert ain endpoints, especially physical/chemical

and fate properties, that SAR and QSAR might be effectively utilized to fulfill these data

requirements for many antimicrobial pesticide chemicals. When c onsidering biological

properties, at this time, EPA believes that SAR and QSAR can be most effectively

utilized in the evaluation of ch emicals that exhibit lower toxi city for human health and/or

ecotoxicity parameters. This is appropriate because the risk assessment for lower toxicity

chemicals can be stream-lined, i.e., a screen ing-level assessment pr ocedure rather than

multiple tiers of assessments with pr ogressively more data requirements.

If stakeholders believe that submission of predicted data can fulfill one of the data

needs for copper 8-quinolinolate, then the Agen cy invites submission of this information.

The submitter would be expected to supply a rationale describing the utility of the

information and provide documentation on the sc ientific validity of the information. The

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### determination that the predicted data fulfills the data requirement would be at the sole

discretion of the Agency. Pre-submission c onsultation with the Agency is encouraged.

Endocrine Disruptor Screening Program

As required under FFDCA section 408(p) , EPA has developed the Endocrine

Disruptor Screening Program (EDSP) to dete rmine whether certain substances (including

pesticide active and other ingred ients) may have an effect in humans or wildlife similar to

an effect produced by a “natur ally occurring estrogen, or othe r such endocrine effects as

the Administrator may designate.” The ED SP employs a two-tiered approach to making

the statutorily required determinations. Tier 1 consists of a battery of 11 screening assays

to identify the potential of a chemical substa nce to interact with the estrogen, androgen,

or thyroid (E, A, or T) hormonal systems. Chemicals that go through Tier 1 screening

and are found to have the potential to inte ract with E, A, or T hormonal systems will

proceed to the next stage of the EDSP wher e EPA will determine which, if any, of the

Tier 2 tests are necessary based on the avai lable data. Tier 2 te sting is designed to

identify any adverse endocrine related eff ects caused by the substance, and establish a

dose-response relationship between th e dose and the E, A, or T effect.

Between October 2009 and February 2010, EPA issued test orders/data call-ins

for the first group of 67 chemicals, which c ontains 58 pesticide ac tive ingredients and 9

inert ingredients. This list of chemicals was selected based on the potential for human

exposure through pathways such as food and wa ter, residential activity, and certain postapplication agricultural s cenarios. This list should not be construed as a list of known or

likely endocrine disruptors.

Copper 8-quinolinolate is not among the group of 58 pesticide active ingredients

on the initial list to be scr eened under the EDSP. Under FFDCA sec. 408(p) the Agency

must screen all pesticide chemicals. Acco rdingly, EPA anticipates issuing future EDSP

test orders/data call-ins fo r Registration Review cases, in cluding those for which EPA has

already opened a Registration Review docke t for a pesticide active ingredient.

For further information on the status of the EDSP, the policies and procedures, the

list of 67 chemicals, the test guidelines and the Tier 1 screening battery, please visit our

website: http://www.epa.gov/endo/.

Additional Information

Stakeholders are also specifically asked to provide available information and data

that will assist the Agency in refining the risk assessments. The Agency is interested in

receiving the following information.

1. Confirmation on the following label information:

a. Sites of application

b. Formulations

c. Application methods and equipment

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### d. Maximum application rates

e. Frequency of application, app lication intervals and maximum

number of applications

f. Geographic limitations on use

2. Use or potential use distribution

3. Use history

4. Usage/use information for non-agricultural uses (e.g., materials

preservation)

5. Typical application interval

6. State or local use restrictions

7. Ecological incidents (non-target plant damage and avian, fish,

reptilian, amphibian and mammalian mo rtalities) not already reported

to the Agency

8. Monitoring data

9. Structure Activity Relationships

Next Steps:

After the 60-day comment period closes, the Agency will review and respond to

any comments received in a timely manner, and then issue a Final Work Plan for copper

8-quinolinolate.

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### II. FACT SHEET

Background Information

 Chemical Name: Copper, bis(8-quinolinolato-N1,O8)-

 Common Names: Copper 8-quino linolate and oxine-copper

 Trade and Other Names: Copper 8, Copper quinolinolate, Copper-8-

hydroxyquinoline

 Registration review case number: 5118

 PC Code: 024002

 CAS#: 10380-28-6

 Technical Registrants: Osmose Inc. and Tanabe U.S.A. Inc.

 First approved for use in a registered product: 1956

 There are 29 registered pr oducts that contain copper 8-quinolinolate as an active

ingredient: 2 manufacturing use prod ucts and 27 end use products

 Antimicrobials Division Chemical Revi ew Manager (CRM): Rebecca von dem

Hagen; vondem-hagen.rebecca@epa.gov

 Antimicrobials Division Product Mana ger (PM): Jacqueline CampbellMcFarlane, campbell-mcfarlane.jacqueline@epa.gov

Chemical Structure:

Use & Usage Information

Type of Pesticide : Algaecide, Bacteriocide/Bacte riostat, Fungicide, Insecticide,

Microbicide, Repellent or Feeding Depressant

Use Sites :

Materials Preservatives

Military/Industrial Textiles, Industrial Cotton, Industrial Fabrics, Webbing, Rope,

Canvas, Leather, Kraft paper, Paperboard, Adhesives, Paints

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### Wood Preservatives

Wood used in Greenhouse Premises, Equi pment and Containers (indirect food

contact), Log Homes, Shingle Roofs, Siding, Fences, Decks, Furniture,

Playground Equipment,

Sills and Baseboards, Structural Building Lumber

Food handling/storage establishm ents, premises and equipment

Potato Processing, Storage a nd Transportation Facilities

Recent Regulatory Actions

In September 2007, the EPA published a Reregistration Eligibility Decision

(RED) for copper 8-quinolinolate. As part of the Reregistration process, the Agency

issued a DCI in June 2010. In response to the product specific DCI, the Agency

anticipates receiving updated labels within 9 mont hs of the date the registrant receives the

DCI. The copper 8-quinolinolate RED can be viewed at http://www.regulations.gov in

docket number EPA-HQ-OPP-2007-0556.

Human Health Risk Assessment Status

The Agency does not anticipate requiring additional human health data for copper

8-quinolinolate for this registration review.

Further human health information is av ailable in the document titled “Human

Health Effects Data for the Copper 8-quinoli nolate Registration Review Decision,” dated

August 30, 2010.

Product Chemistry Database Status

All product chemistry data requirements have been fulfilled for copper 8-

quinolinolate. Therefore, the Agency does not anticipate requiring any additional product

chemistry data for this registration review.

For further information please refer to the Summary of Product Chemistry,

Environmental Fate, and Ecotoxicity Data for the Copper 8-quinolinolate Registration

Review Decision Document, dated July 30, 2010.

Environmental Fate & Ecologi cal Risk Assessment Status

The Agency does not anticipate requiring additional environmental fate and

ecological risk data for copper 8-quino linolate for this registration review.

The Agency has not conducted a risk assessment that supports a complete

endangered species determination for copper 8-quinolinolate. The ecological risk

assessment planned during registration revi ew will allow the Agency to determine

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### whether copper 8-quinolinolate use has “no effect” or “may affect” federally listed

threatened or endangered species (listed specie s) or their designated critical habitats.

When an assessment concludes that a pesticid e’s use “may affect” a listed species or its

designated critical habitat, the Agency w ill consult with the U.S. Fish and Wildlife

Service and/or National Marine Fisheries Se rvices (the Services ), as appropriate.

Further information and detailed justificat ion for the studies that are expected to

be required are available in the document titled, Summary of Product Chemistry,

Environmental Fate, and Ecotoxicity Data for the Copper 8-quinolinolate Registration

Review Decision Document, dated July 26, 2010.

Tolerances

Copper 8-quinolinolate is cleared by the U.S. Food and Drug Administration

(FDA) as an indirect food additive for us e as a component in f ood packaging adhesives

[21 CFR § 175.105(c)]; in paper and paperboard in contact wi th aqueous and fatty foods

(21 CFR § 176.170); in paper and paperboard in contact with dry foods (21 CFR §

176.180); and to preserve wooden articles intended fo r use in packaging, transporting, or

holding raw agricultural pr oducts [21 CFR 178.3800(b)].

There are no tolerances or exemptions fr om tolerances associated with the active

ingredient copper 8-quinolinolate.

Data Call-In Status

Generic and product specific DCIs were issu ed for copper 8-quinolinolate in June

2010 in connection with reregistration.

Labels

There are 29 registered pr oducts that contain copper 8-quinolinolate. The EPA

registration numbers are provi ded in Table 1 below. Fo r future reference, during

registration review a list of product registration numbers will be included in the docket.

Product registration labels may be obtained from the Pesticide Product Label System

(PPLS) website at: http://oaspub.epa.gov/pestlabl/ppls.home

.

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### Table 1. Registered Products Containing Copper 8-quinolinolate

Registration # Registration Name Company Name Formulation

Type % of Active

Ingredient

707-302 Cunilate 2002 Rohm & Haas Co Flowable

Concentrate 10

1022-476 Chapman PQ-8 IBC Manufacturing Co Soluble

Concentrate 5.4

1022-489 PQ-56 IBC Manufacturing Co Soluble

Concentrate 10

1022-490 PQ-57 IBC Manufacturing Co Soluble

Concentrate 5

1022-491 PQ-15 RTU Clear Wood

Preservative IBC Manufacturing Co Ready-to-Use

Solution 0.25

1022-492 PQ-20 IBC Manufacturing Co Soluble

Concentrate 3.75

1022-493 PQ-15 IBC Manufacturing Co Soluble

Concentrate 1.38

1022-503 PQ-7 IBC Manufacturing Co Soluble

Concentrate 3.24

1022-504 PQ-56 RTU IBC Manufacturing Co Ready-to-Use

Solution 0.8

1022-505 PQ-20 R-T-U Wood

Preservative IBC Manufacturing Co Ready-to-Use

Solution 0.25

1022-514 Woodguard-Oil Based

Wood Preservative IBC Manufacturing Co Ready-to-Use

Solution 0.675

2829-42 Socci No. 3500-WP Rohm And Haas

Company Soluble

Concentrate 10

2829-44 Cunilate 2174-NO Rohm And Haas

Company Ready-to-Use

Solution 10

2829-49 Socci No. 3500 Rohm And Haas

Company Soluble

Concentrate 10

2829-112 Cunilate 2419-75 Rohm And Haas

Company Emulsifiable

Concentrate 7.5

2829-135 Nytek 10WP Rohm And Haas

Company Wettable

Powder 10

2829-136 Nytek 10 Rohm And Haas

Company Soluble

Concentrate 10

2829-137 Nytek WD Rohm And Haas

Company Emulsifiable

Concentrate 10

3008-91 ORD-X378 Osmose Inc. Ready-to-Use 34.18



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Formulation % of Active Registration # Registration Name Company Name Type Ingredient

Solution

3008-93 Copper 8-Quino linolate Osmose Inc. Technical

Chemical 96

10829-8 Copper 8-Quinolinolate Tanabe U.S.A. Inc. Technical

Chemical 96

60061-17 Woodtreat C8 Conc entrate Kop-Coat, Inc. Soluble

Concentrate 1.2

60061-18 Woodtreat C8 Ready To

Use Kop-Coat, Inc. Ready-to-Use

Solution 0.25

60061-22 Woodtreat C81 Ready To

Use Water Repellent

Fungicide Kop-Coat, Inc. Ready-to-Use

Solution 1

75341-14 ORD-X240 Osmose Utilities

Services, Inc. Ready-to-Use

Solution .3

81819-1 Q8 Log Oil CTA Products Group Ready-to-Use

Solution 0.675

83515-1 A4 James Hardie Building

Products, Inc. Formulation

Intermediate 98

84397-1 Moldan-10 Environmental RX, Inc. Soluble

Concentrate 10

84711-1 Nylate PW Genett Group, Inc. Ready-to-Use

Solution 0.625



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### III. GLOSSARY of TERMS & ABBREVIATIONS

ai Active Ingredient

AR Anticipated Residue

ASTM American Society for Testing and Materials

AWPA American Wood Preserver’s Association

CFR Code of Federal Regulations

cPAD Chronic Population Adjusted Dose

CSF Confidential Statement of Formula

CSFII USDA Continuing Surveys for Food Intake by Individuals

DCI Data Call-In

DEEM Dietary Exposure Evaluation Model

DFR Dislodgeable Foliar Residue

DNT Developmental Neurotoxicity

DWLOC Drinking Water Level of Comparison

EC Emulsifiable Concentrate Formulation

EDWC Estimated Drinking Water Concentration

EEC Estimated Environmental Concentration

EPA Environmental Protection Agency

EUP End-Use Product

FDA Food and Drug Administration

FIFRA Federal Insecticide, Fungicide, and Rodenticide Act

FFDCA Federal Food, Drug, and Cosmetic Act

FQPA Food Quality Protection Act

FOB Functional Observation Battery

GENEEC Tier I Surface Water Computer Model

IR Index Reservoir

LC 50 Median Lethal Concentration. A statistically derived concentration of a

substance that can be expected to cause death in 50% of test animals. It is

usually expressed as the weight of substance per weight or volume of water, air

or feed, e.g., mg/l, mg/kg or ppm.

LD 50 Median Lethal Dose. A statistically deri ved single dose that can be expected to

cause death in 50% of the test animals when administered by the route indicated

(oral, dermal, inhalation). It is expressed as a weight of substance per unit

weight of animal, e.g., mg/kg.

LOC Level of Concern

LOAEL Lowest Observed Adverse Effect Level

μg/g Micrograms Per Gram

μg/L Micrograms Per Liter

mg/kg/day Milligram Per Kilogram Per Day

mg/L Milligrams Per Liter

MOE Margin of Exposure

MRID Master Record Identifi cation (number). EPA's system of recording and tracking

submitted studies.

MUP Manufacturing-Use Product

NA Not Applicable

NAWQA USGS National Ambient Water Quality Assessment

NPDES National Pollutant Discharge Elimination System

NR Not Required

NOAEL No Observed Adverse Effect Level

OPP EPA Office of Pesticide Programs

OPPTS EPA Office of Prevention, Pesticides and Toxic Substances

PAD Population Adjusted Dose

PAIRA Pure Active Ingredient Radiolabelled

PCA Percent Crop Area

PDP USDA Pesticide Data Program



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### 20 of 34 PHED Pesticide Handler's Exposure Data

PHI Preharvest Interval

ppb Parts Per Billion

PPE Personal Protective Equipment

ppm Parts Per Million

PRZM/EXAMS Tier II Surface Water Computer Model

Q 1 * The Carcinogenic Potential of a Compound, Quantified by the EPA's Cancer

Risk Model

RAC Raw Agriculture Commodity

RED Reregistration Eligibility Decision

REI Restricted Entry Interval

RfD Reference Dose

RQ Risk Quotient

SCI-GROW Tier I Ground Water Computer Model

SAP Science Advisory Panel

SF Safety Factor

SLN Special Local Need (Registrati ons Under Section 24©) of FIFRA)

TGAI Technical Grade Active Ingredient

TEP Typical End-Use Product

USDA United States Department of Agriculture

UF Uncertainty Factor

WPS Worker Protection StandardDocket Number: EPA-HQ-OPP-2010-0454www.regulations.govIV. APPENDIX AUse Patterns for Copper 8-quinolinolateUse SiteFormulationMethod ofApplicationApplication Rate/ No. ofapplicationsUse LimitationsMaterials preservativesSolubleConcentrate:1022-4931022-4922829-422829-492829-13560061-17Textiles, Canvas, Burlap,Rope, Twine, CottonDuck, Cotton Webbing,Twill and CardboardReady to Use:60061-2260061-18Dip, spray, orflow coatWater Based Solution:Dilute 1:20 to 1:50 in waterfor .25% to .75% of copperdepending upon severity ofservice.Immersion:Immersecompletely the object to betreated in the solution for15 to 30 seconds. Allowsufficient time for thetreated objects to dry priorto any further processing.For objects that cannot beimmersed, liberalapplications by flooding,rolling or brushing.Oil Based Solution:1 volume to 5 volumes ofpetroleum oil (or otherorganic solvent) dip for 15seconds to 10 minutesdepending on the tightnessof the weave.Not stated21 of 34Docket Number: EPA-HQ-OPP-2010-0454www.regulations.govUse SiteFormulation Method ofApplicationApplication Rate/ No. ofapplicationsUse LimitationsAdhesives and GluesSolubleConcentrate:10829-8Dispersing inSolvent orAqueousSystemsIt is recommended thatlevels from 0.015 to 0.1%by weight of copper 8-quinolinolate be used forthe protection of adhesivesand glues based on theweight of the finishedproduct, to protect theproduct while in the can.Not statedPaintsSolubleConcentrate:10829-8Dispersing inSolvent orAqueousSystemsCopper 8- quinolinolateshould be used at levels offrom 0.1%to1.0% based onthe volume of the finishedproduct. The median levelof 0.5% to 0.75% is mostgenerally used and hasremained free from moldafter two years underconditions where ordinarypaint becomescontaminated after 60 daysof exposure.Not statedSolubleConcentrate1022-4901022-4892829-44707-302Brush, Sprayor Short DipDilute 1:20 to 1:50 for.25% to .75% of copperdepending upon severity ofservice.Not statedPaper ProductsEmulsifiableApplied at theIncorporate a minimum ofNot stated22 of 34Docket Number: EPA-HQ-OPP-2010-0454www.regulations.govUse SiteFormulation Method ofApplicationApplication Rate/ No. ofapplicationsUse LimitationsConcentrate2829-112Size Press3.2% of product by weightinto the sheet to deposit0.45% copper as metal.Cement, Pulp and PaperIngredientsFormulationIntermediate83515-1Not statedFor formulation into enduse products as an additiveto control mold andmildew on cement and/orpulp paper ingredients insuch products.Not for use in food grade paper, paperboard,and paper coating.This product is a concentrate specificallydesigned to be usedin a manufacturingfacility where dosing and dusting can becontrolled.Adhesives, Kraft Paper,Paints, Paperboard andTextilesAdhesives, Kraft Paper,Paints, Paperboard andTextiles (Continued)SolubleConcentrate84397-1SolubleConcentrate84397-1Spray and DipSpray and DipPaper and PaperboardProducts:Use a minimumlevel of 5.5% of thisproduct by weight(equivalent to 0.1% Cu) forincorporation into theproduct.This rate is recommendedto control mold, mildewand fungal degradation.Kraft Papers are treated bydip and dry methods.Paperboard and heavyKrafts are treated byadding this product to thepulp followed by thoroughmixing of the pulp and thisNot statedNot stated23 of 34Docket Number: EPA-HQ-OPP-2010-0454www.regulations.govUse SiteFormulation Method ofApplicationApplication Rate/ No. ofapplicationsUse LimitationsAdhesives, Kraft paper,Paints, Paperboard andTextiles (Continued)SolubleConcentrate84397-1Spray and Dipproduct.Military Shoe CounterSpecifications: 0.5% to0.10% Cu.Textiles: Use a minimumlevel of 8.3% of thisproduct by weight(equivalent to 0.15% Cu)for control of textiles mold,mildew and fungaldegradation. Waterrepellents can beincorporated with thisproduct into the textiles.Before incorporating theseproducts, check to be surethat the forms flakes,sludges, jells, oily films orlayers, or otherprecipitates. If these areobserved, the mixture ofthis product with the waterrepellant should not beused.Adhesives:For dried filmprotection of adhesives andNot stated24 of 34Docket Number: EPA-HQ-OPP-2010-0454www.regulations.govUse SiteFormulation Method ofApplicationApplication Rate/ No. ofapplicationsUse Limitationsglues, use this product at2.8% to 5.8% by weight ofthe dry material.Synthetic emulsions(ethylene-vinyl acetate)and naturally derivedstarches, dextrins andanimal glues are protectedfrom mildew by a thoroughmixing of this product inthe final compounding ofthe adhesive.Paints:Add this product tointerior latex paints at ratesranging from 1% to 10%by volume of paint.Optimum protection of thepaint film from mold andmildew are obtained withclose levels of 7.5% (v/v).Spray Applications:Dilute this product withwater by mixing 1 part ofthis product with between15 and 60 parts water.Apply as a coarse spray tothoroughly cover the wood25 of 34Docket Number: EPA-HQ-OPP-2010-0454www.regulations.govUse SiteFormulation Method ofApplicationApplication Rate/ No. ofapplicationsUse LimitationsAdhesives, Kraft paper,Paints, Paperboard andTextiles (Continued)SolubleConcentrate84397-1Spray and Dipsurface. Collect anysolution that runs off fromthe treated wood so it canbe re-used. One gallon ofthe diluted spray solutionwill treat 150 to 250 sq. ft.of wood, depending on thewood type.Dip Applications:Dilutethis product with water bymixing 1 part of thisproduct between 15 and 40parts of water.Ensure that the placementof the wood allows allwood surfaces to becompletely covered intreatment solution. Allowthe wood to be immersedin the equipment, allowany treatment solution todrip back into theequipment for re-use. Fiveto ten gallons of the diluteddipping solution will treat1,000 board feet.Not stated26 of 34Docket Number: EPA-HQ-OPP-2010-0454www.regulations.govUse SiteFormulation Method ofApplicationApplication Rate/ No. ofapplicationsUse LimitationsPaper and Paperboard(Wallboard), Brown PaperMills, Sheet forCorrugated Board, KraftPaper and NewsprintReady-to-Use84711-1Spray or DipSpray or dip Kraft Paper orPaperboard (Wallboard)with this product, thenallow the product to dry.Do not apply this product in a way that willcontact workers or other persons, eitherdirectly or through drift. Only protectedhandlers may be in the area duringapplication.This product is only for use in non-foodapplications.Wood preservativesWood Used in AboveGround Service andGround Contact ServiceSolubleConcentrate1022-4891022-4902829-137Dip, Spray orFlow CoatAbove Ground Service:For mild conditions, applyliberally by brush or sprayat 1:20 use dilution inwater. For severeconditions, dip for aminimum of three minutes.For Ground contactService: For mildconditions, apply bydipping for 12 – 48 hoursat a 1:10 dilution in water.For Severe Service: use a1:4 use dilution in waterand dip for 12-48 hours.Not statedWood Items: Used inSolubleDip orIt is recommended thatNone stated27 of 34Docket Number: EPA-HQ-OPP-2010-0454www.regulations.govUse SiteFormulation Method ofApplicationApplication Rate/ No. ofapplicationsUse LimitationsPackaging, Transporting,or Holding AgriculturalProducts; WoodenDecking for Trucks,Trailers, Railroad Cars,Patios, Beverage Cases,Interior Plywood andLumber Walls, Ceilings ofVans and RefrigeratorVan Bodies, Rail Beams,Ladders, Interior Bolds ofBoats, Framing Lumber inFloors and Walls ofShower Rooms, WoodUsed Around SwimmingPools (and Roofs), WoodUsed for Construction ofFood ProcessingEstablishments andWarehousesConcentrate2829-136PressureTreatmentlevels of 0.15 to 1.0% byweight of the product beused in the protection ofadhesives and glues, basedon the weight of thefinished product.This product should beincorporated at levels 5 to10% based on the volumeof paint. The medium levelof 7.5% is most generallyused.Wood PreservationShingles, Siding,Millwork, Timber,Furniture, Poles, Posts,Decks, Greenhouse Items,Playground Equipment,Window Sills and Frames,Fascia Boards, LogHomes, Roofs, OldSolubleconcentrate:1022-4761022-503Dip, Spray, orFlow CoatBase Strength:1 gallon to 150-250 gallonsof water.Stronger than BaseStrength:1 gallon to 30-50 gallons ofwater.None stated28 of 34Docket Number: EPA-HQ-OPP-2010-0454www.regulations.govUse SiteFormulation Method ofApplicationApplication Rate/ No. ofapplicationsUse LimitationsWeathered Wood andNew Porous WoodReady to use:1022-5051022-5041022-4911022-514The most effectivetreatment is obtained withpressure treating orextended soaking wheredeep penetration and highabsorption are obtained.With spraying or brushingmultiple flowing coatsshould be applied.Solubleconcentrate:1022-4761022-503Base Strength:1 gallon to 150-250 gallonsof water.Stronger than BaseStrength:1 gallon to 30-50 gallons ofwater.Wood used in GreenhousePremises Equipment andContainers (indirect foodcontact) Wood in Contactwith Fruit, Vegetables andother Food StuffsIncluding Boxes and Bins,Mushrooms Trays, Pallets,Nursery Trays, Flats,Stakes and FencesReady to Use:1022-5051022-5041022-4911022-514Dip, Spray, orFlow CoatThe most effectivetreatment is obtained withpressure treating orextended soaking wheredeep penetration and highabsorption are obtained.With spraying or brushingmultiple flowing coatsshould be appliedNone statedLumber (2 inch thick orless) Sapstain ControlSolubleConcentrate:Dip, Spray, orFlow CoatBase strength:1 gallon to 150-250 gallonsNone stated29 of 34Docket Number: EPA-HQ-OPP-2010-0454www.regulations.govUse SiteFormulation Method ofApplicationApplication Rate/ No. ofapplicationsUse Limitations1022-4761022-503Ready to use:3008-91of waterStronger than BaseStrength:1 gallon to 30-50 gallons ofwaterWood PreservativesTechnicalChemical3008-93Not StatedThis product is for theformulation of woodpreservatives and in theproduction of porouscement surfaces.This product may be used to formulateproducts for any additional uses not listed onthe label if the formulator has compiled withU.S. EPA data submission requirementsregarding support of such uses.In-Service Poles, Postsand Other TimberMembersReady-to-Use75341-14Brush, Trowelor PumpExternal Treatment:Apply to a thickness of1/16” on poles or timber.Typical pole application isfrom 3” above to 18”below ground line andlower where deeper decayis suspected. Applicationon poles to be restoredshould extend the length ofNot for household use.30 of 34Docket Number: EPA-HQ-OPP-2010-0454www.regulations.govUse SiteFormulation Method ofApplicationApplication Rate/ No. ofapplicationsUse Limitationswrap-around type repairsystems. Wrap area withwater-proof bandage,OSMOSHIELD.Internal Treatment:Forcontrol of internal decay inpoles and other timbers,holes may be drilled inareas of the poles or timberwhere protection isrequired. Fill drilled holes,decay pockets, and voidsusing a grease gun or otherpressurized applicator.Plug application holes withsecure- fitting dowels.Water Repellent WoodPreservativeReady-to-Use81819-1Spray, Brushor RollerApplication:Surfaces tobe treated should bebleached or acid cleanedand free of all loose debris.For maximum penetrationand fastest drying apply todry wood. This productcan be applied to dampwood but expect reducedperformance.Do not apply to non-porous or film coveredsurfaces that prevent or significantly retardpenetration.31 of 34Docket Number: EPA-HQ-OPP-2010-0454www.regulations.govUse SiteFormulation Method ofApplicationApplication Rate/ No. ofapplicationsUse LimitationsWater Repellent WoodPreservative(Continued)Ready-to-Use81819-1Spray, Brushor RollerApply one coat of thisproduct liberally to thesurface to be treated bywetting down the surfaceas follows:Spray- Using pump-upgarden type sprayequipment set the sprayernozzle to deliver a coarse,low pressure spray, andbackrush as needed.Roller or Brushapplications are suitable ifapplied to the point ofrefusal. Spray applicationsare preferred whenpossible.Do not apply to non-porous or film coveredsurfaces that prevent or significantly retardpenetration.Above Ground Uses:Decking for Trucks,Patios, Swimming Pools,Ladders, Boat Interiors,Gypsum Board orPanelings in ShowerRoomsSolubleConcentrate84397-1Dip or PaintDilute this product as a1:10 dilution in water. Dipthe wood to be treated inthis product for threeminutes. Alternatively, thewood can be painted using1 gallon of a 1:10 dilutionof this product per 450 sq.Not stated32 of 34Docket Number: EPA-HQ-OPP-2010-0454www.regulations.govUse SiteFormulation Method ofApplicationApplication Rate/ No. ofapplicationsUse Limitationsft. of wood.Above Ground Uses:Decking for Trucks,Patios, Swimming Pools,Ladders, Boat Interiors,Gypsum Board orPanelings in ShowerRooms (Continued)Ready-to-Use84711-1Ready-to-Use84711-1Dip, Spray orPaintDip, Spray orPaintWood:Wood can either besprayed or dipped in thisproduct for three minutes.Alternatively the wood canbe painted using 1 gallonof this product per 450 sq.ft. of wood.Spray Applications:Apply this product as acoarse spray to thoroughlycover the wood surface.Collect any solution thatruns off from treated woodso it can re-used.One gallon of the dilutedspray solution will treat150-250 sq. ft. of wood,depending upon woodtype.Dip Applications:Ensurethat the placement of woodin a dip tank containingthis product allows allwood surfaces to becompletely covered by theDo not apply this product in a way that willcontact workers or other persons, eitherdirectly or through drift. Only protectedhandlers may be in the area duringapplication.Do not apply this product in a way that willcontact workers or other persons, eitherdirectly or through drift. Only protectedhandlers may be in the area duringapplication.33 of 34Docket Number: EPA-HQ-OPP-2010-0454www.regulations.gov34 of 34Use Site Formulation Method ofApplicationApplication Rate/ No. ofapplicationsUse Limitationstreatment solution. Allowthe wood immersed in thetreatment solution for aminimum of three minutes.After removing the woodfrom the dippingequipment, allow anytreatment solution to dripback into the equipment forre-use. Five to ten gallonsof the dipping solution willtreat 1,000 board feet.Food handling/storage establishments, premises and equipmentPotato processing, storageand transportationfacilitiesSolubleConcentrate:1022-4891022-49075675-1SprayApplicatorPre-clean area and allow toair dry before applying.Dilute 1:100-200 in waterwith careful agitation tolessen foaming. Spray allsurfaces with a non-misttype nozzle set at approx.20 psi.Although not phototoxic to cut seed potatoes,DO NOT treat the potato seed surfaces.