<TABLE> <S> <C>


<ARTICLE>                     5
<CIK>     0000849043
<NAME>    Neurogen Corporation
<MULTIPLIER>                                   1,000

<S>                                               <C>               <C>                  <C>

<PERIOD-TYPE>                                  YEAR              YEAR                YEAR
<FISCAL-YEAR-END>                              DEC-31-1999       DEC-31-1998         DEC-31-1997
<PERIOD-START>                                 JAN-01-1999       JAN-01-1998         JAN-01-1997
<PERIOD-END>                                   DEC-31-1999       DEC-31-1998         DEC-31-1997
<CASH>                                         31,588            26,066              66,924
<SECURITIES>                                   33,441            48,944              17,227
<RECEIVABLES>                                  0                 0                   0
<ALLOWANCES>                                   0                 0                   0
<INVENTORY>                                    0                 0                   0
<CURRENT-ASSETS>                               66,236            76,964              86,465
<PP&E>                                         35,455            31,755              29,851
<DEPRECIATION>                                 9,840             7,265               4,950
<TOTAL-ASSETS>                                 92,134            101,810             111,869
<CURRENT-LIABILITIES>                          5,464             3,195               4,823
<BONDS>                                        0                 0                   0
<PREFERRED-MANDATORY>                          0                 0                   0
<PREFERRED>                                    0                 0                   0
<COMMON>                                       370               366                 360
<OTHER-SE>                                     (251)             74                  (3)
<TOTAL-LIABILITY-AND-EQUITY>                   92,134            101,810             111,869
<SALES>                                        0                 0                   0
<TOTAL-REVENUES>                               10,209            11,081              17,979
<CGS>                                          0                 0                   0
<TOTAL-COSTS>                                  28,465            24,834              23,276
<OTHER-EXPENSES>                               (3,638)           (4,295)             (5,040)
<LOSS-PROVISION>                               0                 0                   0
<INTEREST-EXPENSE>                             (1)               (17)                (35)
<INCOME-PRETAX>                                (14,618)          (9,458)             (257)
<INCOME-TAX>                                   0                 0                   0
<INCOME-CONTINUING>                            (14,618)          (9,458)             (257)
<DISCONTINUED>                                 0                 0                   0
<EXTRAORDINARY>                                0                 0                   0
<CHANGES>                                      0                 0                   0
<NET-INCOME>                                   (14,618)          (9,458)             (257)
<EPS-BASIC>                                  (1.00)            (.66)               (.02)
<EPS-DILUTED>                                  (1.00)            (.66)               (.02)



</TABLE>