----

----

|  Delaware(State      or other jurisdictionof      incorporation or organization)                          |  22-2845714(I.R.S.      EmployerIdentification      No.) |
|----------------------------------------------------------------------------------------------------------------|---------------------------------------------------------------|
|  45      Northeast Industrial RoadBranford,      Connecticut(Address      of principal executive offices) |  06405(Zip      Code)                                    |

| Securities      registered pursuant to Section 12 (b) of the Act: |
|-------------------------------------------------------------------|
|                                                              |   |   |
| Title      of each class                                          |   | Name      of each exchange on which registered |
| Common      Stock, par value $.025 per share                      |   | The      NASDAQ Stock Market LLC |
| (the      “Common Stock”)                             |   |   |
|                                                              |   |   |
| Securities      registered pursuant to Section 12(g) of the Act:  |
|                                                              | None |   |

----

PARTIII

| Name      of Nominees               |   | Age |   | Principal      Occupation                                                                                        |   | Director      Since |
|-------------------------------------|--------|-----|--------|------------------------------------------------------------------------------------------------------------------|--------|---------------------|
| Julian      C. Baker           |   | 42  |   | Managing      Member, Baker Bros. Advisors, LLC                                                                  |   | May      1999       |
| Eran      Broshy               |   | 50  |   | Chief      Executive Officer and Director of inVentiv Health, Inc.                                               |   | July      2003      |
| Stephen      R. Davis          |   | 48  |   | President      and Chief Executive Officer, Neurogen Corporation                                                 |   | September 2001 |
| Stewart      Hen               |   | 42  |   | Managing      Director, Warburg Pincus LLC                                                                       |   | April      2004     |
| John      L. LaMattina, Ph.D.  |   | 59  |   | Former      Head of Global Research and Development, Pfizer, Inc.                                                |   | February      2008  |
| Craig      Saxton, M.D.             |   | 66  |   | Former      Executive Vice President, Pfizer Global Research and Development and Vice      President, Pfizer Inc |   | January      2002   |
| John      Simon, Ph.D.              |   | 66  |   | Managing      Director, Allen & Company LLC                                                                  |   | May      1989       |

----

----

| Name                                   |   | Age |   | Company      Position                                               |   | Officer      Since  |
|----------------------------------------|--------|-----|--------|---------------------------------------------------------------------|--------|---------------------|
| Stephen      R. Davis                  |   | 48  |   | President      and Chief Executive Officer                          |   | September      2001 |
| Thomas      A. Pitler, Ph.D.           |   | 50  |   | Senior      Vice President and Chief Business and Financial Officer |   | April      2008     |
| Kenneth      J. Sprenger, M.D., MBBCh. |   | 56  |   | Senior      Vice President, Clinical Development and Operations     |   | April      2009     |
| Srdjan      Stankovic, M.D., MSPH      |   | 52  |   | Executive      Vice President and Chief Development Officer         |   | April      2008     |

----

Compensation of Named ExecutiveOfficers

| Named      Executive Officer andPrincipal      Position                                                                                   | Year | Salary($) | OptionAwards      (1)($) | Non-EquityIncentive      PlanCompensation      (2)($)                     | AllOtherCompensation      (3)($) | Total($)  |
|-------------------------------------------------------------------------------------------------------------------------------------------|------|-----------|--------------------------|---------------------------------------------------------------------------|----------------------------------|-----------|
| Stephen      R. DavisPresident,      andChief      Operating Officer                                                                      | 2008 | 421,566   | 457,591                  |                 164,900 | 26,859                           | 1,070,916 |
|                                                                                                                                      | 2007 | 353,145   | 364,941                  |        65,091                                                        | 25,552                           | 808,729   |
| Srdjan      Stankovic, M.D., MSPHExecutive      Vice President, andChief      Development Officer                                         | 2008 | 272,090   | 73,577                   | 109,060                                                                   | 36,876                           | 491,603   |
|                                                                                                                                      | 2007 | -         | -                        | -                                                                         | -                                | -         |
| Thomas      A. Pitler, Ph.D.Senior      Vice President, andChief      Business and Financial Officer                                      | 2008 | 273,563   | 194,168                  | 62,300                                                                    | 26,771                           | 556,802   |
|                                                                                                                                      | 2007 | 250,700   | 180,393                  | 32,122                                                                    | 25,449                           | 488,664   |
| Kenneth      J. Sprenger, M.D., MBBCh.Senior      Vice President, Clinical    Development and      Operations Officer | 2008 | 273,648   | 161,391                  | 45,758                                                                    | 20,990                           | 501,787   |
|                                                                                                                                      | 2007 | 247,095   | 98,521                   | 26,200                                                                    | 21,207                           | 393,023   |

----

| (1) | Represents      the compensation expense of stock options granted in the current and prior      years for financial reporting purposes for the year ended December 31,      2008 under SFAS 123(R). See Note 8 to the Company’s consolidated      financial statements, as set forth in the Company’s Annual Report on Form      10-K for the period ended December 31, 2008, for the assumptions made in      determining SFAS 123(R) values, except that for purposes of the amounts      shown, no forfeitures were assumed to take place. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (2) | The      amount reported in this column reflects the value of cash incentive      bonuses earned in the year reported but paid in the following year under      the Company’s Annual Cash Incentive Plan.                                                                                                                                                                                                                                                                                                                                           |
| (3) | All      Other Compensation for fiscal 2008 as shown above is detailed in the table      below entitled “All Other Compensation – 2008”. .                                                                                                                                                                                                                                                                                                                                                                                              |

Annual Cash IncentiveAwards

| Named      Executive Officer           | Bonus      Target Expressed as a Percentage of Base Salary | Ratio      of Bonus Based on Overall Corporate/Specific      Corporate/Individual Performance |
|----------------------------------------|------------------------------------------------------------|----------------------------------------------------------------------------------------------------|
| Stephen      R. Davis                  | 50%                                                        | 40%      / 40% / 20%                                                                               |
| Srdjan      Stankovic, M.D., MSPH      | 35%                                                        | 40%      / 30% / 30%                                                                               |
| Thomas      A. Pitler, Ph.D.           | 25%                                                        | 30%      / 30% / 40%                                                                               |
| Kenneth      J. Sprenger, M.D., MBBCh. | 20%                                                        | 25%      / 25% / 50%                                                                               |

----

|     § | Successful      completion of planned clinical studies. (aggregate approximate      weighting of 70%)                                                |
|--------------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------|
|     § | Advancement      of non-clinical activities necessary to support ongoing and planned      clinical studies. (aggregate approximate weighting of  5%) |
|     § | Pursue      financing and strategic relationships, and sale of non-core assets      (aggregate approximate weighting of25%)                               |

| Named      Executive Officer           | Accomplishment      of Targeted Objectives | Actual      Bonus as a Percentage of Salary |
|----------------------------------------|--------------------------------------------|---------------------------------------------|
| Stephen      R. Davis                  | 77.6%                                      | 38.8%                                       |
| Srdjan      Stankovic, M.D., MSPH      | 82.0%                                      | 28.7%                                       |
| Thomas      A. Pitler, Ph.D.           | 83.8%                                      | 21.0%                                       |
| Kenneth      J. Sprenger, M.D., MBBCh. | 83.7%                                      | 16.8%                                       |

----

|  Named Executive Officer          |   | Life,      Accidental Death and Dismemberment Insurance premiums paid by      Company($) |   |   | Medical      Premiums paid by company($) |   |   | Moving      & Relocation($) |   |    | Dental      Premiums paid by company($) |   |   | Other($) |   |   | 401(k)      Match($) |   |   | Total($) |   |
|----------------------------------------|--------|------------------------------------------------------------------------------------------|--------|--------|------------------------------------------|--------|--------|---------------------------------|--------|---------|-----------------------------------------|--------|--------|----------|--------|--------|----------------------|--------|--------|----------|--------|
| Stephen      R. Davis                  |   |                                                                                     | 1,722  |   |                                     |   | 10,106 |                            |   |  - |                                    |   |   | 1,231    |   |   |  -              |   |   |     | 13,800 |   |   |   | 26,859 |   |
| Srdjan      Stankovic, M.D., MSPH      |   |                                                                                     | 1,148  |   |                                     |   | -      |                            |   |    | 25,700                                  |   |   |     | -      |   |                 | -      |   |     |   | 10,028 |   |   |   | 36,876 |   |
| Thomas      A. Pitler, Ph.D.           |   |                                                                                     | 1,634  |   |                                     |   | 10,106 |                            |   |    | -                                  |   |   |     | 1,231  |   |                 | -      |   |     |   | 13,800 |   |   |   | 26,771 |   |
| Kenneth      J. Sprenger, M.D., MBBCh. |   |                                                                                     | 1,667  |   |                                     |   | 4,588  |                            |   |    | -                                  |   |   |     | 516    |   |                 |   | 419    | (1)      |   |   | 13,800 |   |   |   | 20,990 |   |

|   | (1)      Dr. Sprenger was paid this amount to cover certain entertainment expenses      in return for leaving a planned vacation to attend a company      meeting. |
|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

----

|     § | If      the executive is terminated without cause, or if the executive terminates      his employment for good reason not in connection with a change of control,      he will be entitled to: (i) a lump sum payment in an amount equal to his      then current base salary, (ii) continuation of the health and welfare      benefits (or the economic equivalent thereof) for one year after the      termination and (iii) the right to exercise immediately any stock options      and to freely trade any restricted stock that, but for such termination,      would have become exercisable or tradable, as the case may be, within one      year of the date of suchtermination. |
|--------------------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|     § | In      addition to the foregoing, if the executive is terminated without cause or      terminates his employment for good reason as a result of a change of      control (including without limitation any termination within two years of      a change of control) then he shall also be entitled to a lump sum payment      in an amount equal to the greater of: (i) his then targeted annual bonus      or (ii) his annual bonus immediately prior to the change of      control.   Mr. Davis’s employment agreement further provides      that in the event of a change of control, on the first annual anniversary      of the effective date of such change of control, all stock options granted      to him prior to the effective date of the change of control that have not      otherwise vested or expired shall automatically vest and be      exercisable. |
|--------------------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|     § | If      the executive’s employment is terminated due to disability, the executive      will be entitled to: (i) continuation of payment of his base salary until      he commences to receive payments under the Company’s long-term disability      plan, (ii) continuation of the health and welfare benefits (or the      economic equivalent thereof) for one year after the date of termination      and (iii) the right to exercise immediately that proportion of the stock      options which would become exercisable on or before the anniversary date      of the employment agreement immediately following the date of termination      equal to the number of days worked by the executive since the preceding      anniversary date to the termination date, divided by 365    days. |
|--------------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|     § | If      the Company provides the executive with a notice of non-renewal for the      employment agreement in accordance with the notice provisions of the      agreement, the executive will be entitled to: (i) continuation of payment      of his base salary for a period equal to one year less the number of days      notice given by the Company to the executive that it does not wish to      extend or further extend the employment agreement, (ii) continuation of      the health and welfare benefits (or the economic equivalent) for one year      after such termination and (iii) the right to exercise immediately any      stock options and to trade freely any restricted stock granted to the      executive which, but for such termination, would have become exercisable      or freely tradable, as the case may be, on or before the anniversary date      of the agreement immediately following the date on which the continuation      of his base salary ends; provided, however, that the amounts paid to the      executive in the form of continued base salary payments shall be offset on      a dollar for dollar basis by any cash, or the fair market value of any      non-cash, remuneration, benefit or other entitlement earned, received or      receivable by him in connection with the employment of him in any      capacity, other than dividends, interest income or other passive      investment income earned as a result of an interest in a business or      entity of which he owns less than 2% of the beneficial      ownership. |
|--------------------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Name                     | GrantDate  | Number      of SecuritiesUnderlying      UnexercisedOptions      Exercisable(#) | Number      of SecuritiesUnderlying      UnexercisedOptions      Unexercisable(#) | OptionExercisePrice($) | Option      ExpirationDate |   |
|--------------------------|------------|---------------------------------------------------------------------------------|-----------------------------------------------------------------------------------|------------------------|----------------------------|--------|
| Stephen      R. Davis    | 12/19/2002 | 8,750                                                                           | -                                                                                 | $3.870000              | 12/19/2010                 | (1)    |
|                     | 12/19/2002 | 8,750                                                                           | -                                                                                 | $3.870000              | 12/19/2011                 | (1)    |
|                     | 12/15/2003 | 7,875                                                                           | -                                                                                 | $8.790000              | 12/15/2009                 | (1)    |
|                     | 12/15/2003 | 7,875                                                                           | -                                                                                 | $8.790000              | 12/15/2010                 | (1)    |
|                     | 12/15/2003 | 7,875                                                                           | -                                                                                 | $8.790000              | 12/15/2011                 | (1)    |
|                     | 12/15/2003 | 7,875                                                                           | -                                                                                 | $8.790000              | 12/15/2012                 | (1)    |
|                     | 12/21/2004 | 25,000                                                                          | -                                                                                 | $9.050000              | 12/21/2012                 | (1)    |
|                     | 12/21/2004 | 25,000                                                                          | -                                                                                 | $9.050000              | 12/21/2013                 | (1)    |
|                     | 12/21/2004 | 25,000                                                                          | -                                                                                 | $9.050000              | 12/21/2010                 | (1)    |
|                     | 12/21/2004 | 25,000                                                                          | -                                                                                 | $9.050000              | 12/21/2011                 | (1)    |
|                     | 12/16/2005 | 6,930                                                                           | -                                                                                 | $7.880000              | 12/16/2011                 | (1)    |
|                     | 12/16/2005 | 6,930                                                                           | -                                                                                 | $7.880000              | 12/16/2012                 | (1)    |
|                     | 12/16/2005 | 6,930                                                                           | -                                                                                 | $7.880000              | 12/16/2013                 | (1)    |
|                     | 12/16/2005 | -                                                                               | 6,930                                                                             | $7.880000              | 12/16/2014                 | (1)    |
|                     | 12/15/2006 | 9,100                                                                           | -                                                                                 | $5.780000              | 12/15/2012                 | (1)    |
|                     | 12/15/2006 | 9,100                                                                           | -                                                                                 | $5.780000              | 12/15/2013                 | (1)    |
|                     | 12/15/2006 | -                                                                               | 9,100                                                                             | $5.780000              | 12/15/2014                 | (1)    |
|                     | 12/15/2006 | -                                                                               | 9,100                                                                             | $5.780000              | 12/15/2015                 | (1)    |
|                     | 1/17/2007  | -                                                                               | 12,000                                                                            | $6.200000              | 1/17/2015                  | (2)    |
|                     | 12/20/2007 | 6,563                                                                           | -                                                                                 | $3.560000              | 12/20/2013                 | (1)    |
|                     | 12/20/2007 | -                                                                               | 6,563                                                                             | $3.560000              | 12/20/2014                 | (1)    |
|                     | 12/20/2007 | -                                                                               | 6,562                                                                             | $3.560000              | 12/20/2015                 | (1)    |
|                     | 12/20/2007 | -                                                                               | 6,562                                                                             | $3.560000              | 12/20/2016                 | (1)    |
|                     | 4/24/2008  | 29,750                                                                          | -                                                                                 | $1.200000              | 7/24/2013                  | (3)    |
|                     | 4/24/2008  | 29,750                                                                          | -                                                                                 | $1.200000              | 10/24/2013                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 29,750                                                                            | $1.200000              | 1/24/2014                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 29,750                                                                            | $1.200000              | 4/24/2014                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 29,750                                                                            | $1.200000              | 7/24/2014                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 29,750                                                                            | $1.200000              | 10/24/2014                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 29,750                                                                            | $1.200000              | 1/24/2015                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 29,750                                                                            | $1.200000              | 4/24/2015                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 29,750                                                                            | $1.200000              | 7/24/2015                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 29,750                                                                            | $1.200000              | 10/24/2015                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 29,750                                                                            | $1.200000              | 1/24/2016                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 29,750                                                                            | $1.200000              | 4/24/2016                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 4,366                                                                             | $1.200000              | 7/24/2016                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 25,384                                                                            | $1.200000              | 7/24/2016                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 29,750                                                                            | $1.200000              | 10/24/2016                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 29,750                                                                            | $1.200000              | 1/24/2017                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 29,750                                                                            | $1.200000              | 4/24/2017                  | (3)    |
|                     | 7/25/2008  | 14,000                                                                          | -                                                                                 | $1.200000              | 7/24/2013                  | (3)    |
|                     | 7/25/2008  | 14,000                                                                          | -                                                                                 | $1.200000              | 10/24/2013                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 14,000                                                                            | $1.200000              | 1/24/2014                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 14,000                                                                            | $1.200000              | 4/24/2014                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 14,000                                                                            | $1.200000              | 7/24/2014                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 14,000                                                                            | $1.200000              | 10/24/2014                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 14,000                                                                            | $1.200000              | 1/24/2015                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 14,000                                                                            | $1.200000              | 4/24/2015                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 14,000                                                                            | $1.200000              | 7/24/2015                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 14,000                                                                            | $1.200000              | 10/24/2015                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 14,000                                                                            | $1.200000              | 1/24/2016                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 14,000                                                                            | $1.200000              | 4/24/2016                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 14,000                                                                            | $1.200000              | 7/24/2016                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 14,000                                                                            | $1.200000              | 10/24/2016                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 14,000                                                                            | $1.200000              | 1/24/2017                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 14,000                                                                            | $1.200000              | 4/24/2017                  | (3)    |
|                     |       |                                                                            |                                                                              |                   |                       |
| Thomas      A. Pitler    | 12/31/1999 | 15,000                                                                          | -                                                                                 | $16.500000             | 12/31/2009                 | (4)    |
|                     | 12/31/2000 | 7,000                                                                           | -                                                                                 | $35.125000             | 12/31/2010                 | (4)    |
|                     | 12/31/2001 | 1,440                                                                           | -                                                                                 | $17.484375             | 12/31/2009                 | (4)    |
|                     | 12/31/2001 | 1,440                                                                           | -                                                                                 | $17.484375             | 12/31/2011                 | (4)    |
|                     | 12/31/2001 | 1,440                                                                           | -                                                                                 | $17.484375             | 12/31/2011                 | (4)    |
|                     | 12/19/2002 | 1,206                                                                           | -                                                                                 | $3.870000              | 12/19/2010                 | (4)    |
|                     | 12/19/2002 | 1,206                                                                           | -                                                                                 | $3.870000              | 12/19/2011                 | (4)    |
|                     | 12/19/2002 | 1,206                                                                           | -                                                                                 | $3.870000              | 12/19/2012                 | (4)    |
|                     | 12/15/2003 | 1,463                                                                           | -                                                                                 | $8.790000              | 12/15/2009                 | (1)    |
|                     | 12/15/2003 | 1,463                                                                           | -                                                                                 | $8.790000              | 12/15/2010                 | (1)    |
|                     | 12/15/2003 | 1,462                                                                           | -                                                                                 | $8.790000              | 12/15/2011                 | (1)    |
|                     | 12/15/2003 | 1,462                                                                           | -                                                                                 | $8.790000              | 12/15/2012                 | (1)    |
|                     | 5/21/2004  | 10,000                                                                          | -                                                                                 | $9.500000              | 5/21/2010                  | (1)    |
|                     | 5/21/2004  | 10,000                                                                          | -                                                                                 | $9.500000              | 5/21/2011                  | (1)    |
|                     | 5/21/2004  | 10,000                                                                          | -                                                                                 | $9.500000              | 5/21/2012                  | (1)    |
|                     | 5/21/2004  | 10,000                                                                          | -                                                                                 | $9.500000              | 5/21/2013                  | (1)    |
|                     | 12/21/2004 | 5,000                                                                           | -                                                                                 | $9.050000              | 12/21/2010                 | (1)    |
|                     | 12/21/2004 | 5,000                                                                           | -                                                                                 | $9.050000              | 12/21/2011                 | (1)    |
|                     | 12/21/2004 | 5,000                                                                           | -                                                                                 | $9.050000              | 12/21/2012                 | (1)    |
|                     | 12/21/2004 | 5,000                                                                           | -                                                                                 | $9.050000              | 12/21/2013                 | (1)    |
|                     | 12/16/2005 | 4,950                                                                           | -                                                                                 | $7.880000              | 12/16/2011                 | (1)    |
|                     | 12/16/2005 | 4,950                                                                           | -                                                                                 | $7.880000              | 12/16/2012                 | (1)    |
|                     | 12/16/2005 | 4,950                                                                           | -                                                                                 | $7.880000              | 12/16/2013                 | (1)    |
|                     | 12/16/2005 | -                                                                               | 4,950                                                                             | $7.880000              | 12/16/2014                 | (1)    |
|                     | 12/15/2006 | -                                                                               | -                                                                                 | $5.780000              | 12/15/2012                 | (1)    |
|                     | 12/15/2006 | -                                                                               | -                                                                                 | $5.780000              | 12/15/2013                 | (1)    |
|                     | 12/15/2006 | -                                                                               | 5,687                                                                             | $5.780000              | 12/15/2014                 | (1)    |
|                     | 12/15/2006 | -                                                                               | 5,687                                                                             | $5.780000              | 12/15/2015                 | (1)    |
|                     | 1/17/2007  | -                                                                               | 50,000                                                                            | $6.200000              | 1/17/2015                  | (2)    |
|                     | 12/20/2007 | 3,282                                                                           | -                                                                                 | $3.560000              | 12/20/2013                 | (1)    |
|                     | 12/20/2007 | -                                                                               | 3,281                                                                             | $3.560000              | 12/20/2014                 | (1)    |
|                     | 12/20/2007 | -                                                                               | 3,281                                                                             | $3.560000              | 12/20/2015                 | (1)    |
|                     | 12/20/2007 | -                                                                               | 3,281                                                                             | $3.560000              | 12/20/2016                 | (1)    |
|                     | 4/24/2008  | 10,625                                                                          | -                                                                                 | $1.200000              | 7/24/2013                  | (3)    |
|                     | 4/24/2008  | 10,625                                                                          | -                                                                                 | $1.200000              | 10/24/2013                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 1/24/2014                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 4/24/2014                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 7/24/2014                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 10/24/2014                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 1/24/2015                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 4/24/2015                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 7/24/2015                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 10/24/2015                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 1/24/2016                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 4/24/2016                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 7/24/2016                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 10/24/2016                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 1/24/2017                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 4/24/2017                  | (3)    |
|                     | 7/25/2008  | -                                                                               | -                                                                                 | $1.200000              | 7/24/2013                  | (3)    |
|                     | 7/25/2008  | -                                                                               | -                                                                                 | $1.200000              | 10/24/2013                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 1/24/2014                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 4/24/2014                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 7/24/2014                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 10/24/2014                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 1/24/2015                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 4/24/2015                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 7/24/2015                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 10/24/2015                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 1/24/2016                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 4/24/2016                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 7/24/2016                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 10/24/2016                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 1/24/2017                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 4/24/2017                  | (3)    |
|                     |       |                                                                            |                                                                              |                   |                       |
| Kenneth      J. Sprenger | 12/6/2005  | 12,000                                                                          | 8,000                                                                             | $7.480000              | 12/6/2015                  | (5)    |
|                     | 12/16/2005 | 1,020                                                                           | -                                                                                 | $7.880000              | 12/16/2011                 | (1)    |
|                     | 12/16/2005 | 1,020                                                                           | -                                                                                 | $7.880000              | 12/16/2012                 | (1)    |
|                     | 12/16/2005 | 1,020                                                                           | -                                                                                 | $7.880000              | 12/16/2013                 | (1)    |
|                     | 12/16/2005 | -                                                                               | 1,020                                                                             | $7.880000              | 12/16/2014                 | (1)    |
|                     | 12/15/2006 | 864                                                                             | -                                                                                 | $5.780000              | 12/15/2012                 | (1)    |
|                     | 12/15/2006 | 864                                                                             | -                                                                                 | $5.780000              | 12/15/2013                 | (1)    |
|                     | 12/15/2006 | -                                                                               | 864                                                                               | $5.780000              | 12/15/2014                 | (1)    |
|                     | 12/15/2006 | -                                                                               | 863                                                                               | $5.780000              | 12/15/2015                 | (1)    |
|                     | 1/17/2007  | -                                                                               | 50,000                                                                            | $6.200000              | 1/17/2015                  | (2)    |
|                     | 12/20/2007 | 3,282                                                                           | -                                                                                 | $3.560000              | 12/20/2013                 | (1)    |
|                     | 12/20/2007 | -                                                                               | 3,281                                                                             | $3.560000              | 12/20/2014                 | (1)    |
|                     | 12/20/2007 | -                                                                               | 3,281                                                                             | $3.560000              | 12/20/2015                 | (1)    |
|                     | 12/20/2007 | -                                                                               | 3,281                                                                             | $3.560000              | 12/20/2016                 | (1)    |
|                     | 4/24/2008  | 10,625                                                                          | -                                                                                 | $1.200000              | 7/24/2013                  | (3)    |
|                     | 4/24/2008  | 10,625                                                                          | -                                                                                 | $1.200000              | 10/24/2013                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 1/24/2014                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 4/24/2014                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 7/24/2014                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 10/24/2014                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 1/24/2015                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 4/24/2015                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 7/24/2015                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 10/24/2015                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 1/24/2016                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 4/24/2016                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 7/24/2016                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 10/24/2016                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 1/24/2017                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 10,625                                                                            | $1.200000              | 4/24/2017                  | (3)    |
|                     | 7/25/2008  | 5,000                                                                           | -                                                                                 | $1.200000              | 7/24/2013                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 1/24/2014                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 4/24/2014                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 7/24/2014                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 10/24/2014                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 1/24/2015                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 4/24/2015                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 7/24/2015                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 10/24/2015                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 1/24/2016                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 4/24/2016                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 7/24/2016                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 10/24/2016                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 1/24/2017                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 5,000                                                                             | $1.200000              | 4/24/2017                  | (3)    |
|                     |       |                                                                            |                                                                              |                   |                       |
| Srdjan      Stankovic    | 4/24/2008  | 12,750                                                                          | -                                                                                 | $1.200000              | 7/24/2013                  | (3)    |
|                     | 4/24/2008  | 12,750                                                                          | -                                                                                 | $1.200000              | 10/24/2013                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 12,750                                                                            | $1.200000              | 1/24/2014                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 12,750                                                                            | $1.200000              | 4/24/2014                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 12,750                                                                            | $1.200000              | 7/24/2014                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 12,750                                                                            | $1.200000              | 10/24/2014                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 12,750                                                                            | $1.200000              | 1/24/2015                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 12,750                                                                            | $1.200000              | 4/24/2015                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 12,750                                                                            | $1.200000              | 7/24/2015                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 12,750                                                                            | $1.200000              | 10/24/2015                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 12,750                                                                            | $1.200000              | 1/24/2016                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 12,750                                                                            | $1.200000              | 4/24/2016                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 12,750                                                                            | $1.200000              | 7/24/2016                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 12,750                                                                            | $1.200000              | 10/24/2016                 | (3)    |
|                     | 4/24/2008  | -                                                                               | 12,750                                                                            | $1.200000              | 1/24/2017                  | (3)    |
|                     | 4/24/2008  | -                                                                               | 12,750                                                                            | $1.200000              | 4/24/2017                  | (3)    |
|                     | 7/25/2008  | 6,000                                                                           | -                                                                                 | $1.200000              | 7/24/2013                  | (3)    |
|                     | 7/25/2008  | 6,000                                                                           | -                                                                                 | $1.200000              | 10/24/2013                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 6,000                                                                             | $1.200000              | 1/24/2014                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 6,000                                                                             | $1.200000              | 4/24/2014                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 6,000                                                                             | $1.200000              | 7/24/2014                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 6,000                                                                             | $1.200000              | 10/24/2014                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 6,000                                                                             | $1.200000              | 1/24/2015                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 6,000                                                                             | $1.200000              | 4/24/2015                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 6,000                                                                             | $1.200000              | 7/24/2015                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 6,000                                                                             | $1.200000              | 10/24/2015                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 6,000                                                                             | $1.200000              | 1/24/2016                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 6,000                                                                             | $1.200000              | 4/24/2016                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 6,000                                                                             | $1.200000              | 7/24/2016                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 6,000                                                                             | $1.200000              | 10/24/2016                 | (3)    |
|                     | 7/25/2008  | -                                                                               | 6,000                                                                             | $1.200000              | 1/24/2017                  | (3)    |
|                     | 7/25/2008  | -                                                                               | 6,000                                                                             | $1.200000              | 4/24/2017                  | (3)    |

----

| (1) | These      options vest in 4 equal annual installments and expire 5 years from each      vesting date.                                                                        |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (2) | These      options vest in full on the third anniversary of the date of grant and      expire 8 years from date of grant.                                                     |
| (3) | These      options vest quarterly in 16 equal installments over a 4 year period from      date of grant with the first installment vesting 91 days after the grant      date. |
| (4) | These      options vest in 5 equal annual installments and expire 5 years from each      vesting date.                                                                        |
| (5) | This      option vest in 5 equal annual installments and expire 10 years from each      vesting date.                                                                         |

----

|                                                                  |   | AnnualRetainer      Fees |    |   | AnnualOption      Awards |   |
|-----------------------------------------------------------------------|--------|--------------------------|---------|--------|--------------------------|--------|
| Chairman      of the Board                                            |   | $                        | 100,000 |   |                     |   | (3) |   |   |   | - |   |   |   |   |
| Chairman      of the Audit Committee                                  |   | $                        | 25,000  |   |                     |   | (2)) | (3) |   |   | 2,500 |   |   |   | (4) |   |
| Chairman      of the Compensation, Governance, or Science Committee   |   | $                        | 5,000   |   |                     |   | (3) |   |   |   | 2,500 |   |   |   | (4) | (5) |
| Member      of the Board of Directors                                 |   | $                        | 25,000  |   |                     |   | (3) |   |   |   | 10,000 |   |   |   | (1) |   |
| Members      of Audit, Governance, Compensation, or Science Committee |   |                     | -       |   |                     |   |   |   |   |   | 1,500 |   |   |   | (4) | (5) |

| (1) | Granted      in quarterly increments of 2,500 options.                                                                                                                                                      |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (2) | Annual      maximum of $5,000 to a director if a director chairs more than one      committee with the exception of the chair of the Audit Committee, who      receives $25,000 annually for that position. |
| (3) | All      annual retainers are paid in quarterly installments.                                                                                                                                               |
| (4) | Granted      annually upon appointment to each committee.                                                                                                                                                   |
| (5) | Annual      maximum of 5,000 options to a director for committee    service.                                                                                                                                |

----

| Name                    | Fees      Earned orPaid      in Cash($) | Stock      Awards($) | Option      Awards (1)      (2)($) | Total($) |
|-------------------------|-----------------------------------------|----------------------|-----------------------------------------|----------|
| Julian      C. Baker    | 30,000                                  | -                    | 10,688                                  | 40,688   |
| Eran      Broshy        | 30,000                                  | -                    | 10,688                                  | 40,688   |
| Stewart      Hen        | 25,000                                  | -                    | 9,569                                   | 34,569   |
| John      L. LaMattina  | 20,810                                  | -                    | 3,543                                   | 24,353   |
| Craig      Saxton, M.D. | 127,500                                 | 42,918               | 15,703                                  | 188,621  |
| John      Simon, Ph.D.  | 50,000                                  | -                    | 5,856                                   | 55,856   |

| (1) | Represents      the compensation costs for financial reporting purposes for the year ended      December 31, 2008 under SFAS 123(R). See Note 8 to the Company’s      consolidated financial statements, as set forth in the Company’s Annual      Report on Form 10-K for the period ended December 31, 2008, for the      assumptions made in determining SFAS 123(R) values, except that for      purposes of the amounts shown, no forfeitures were assumed to take      place.  Based upon the retirement provisions of the plan      documents the full compensation expense is recorded as of the date of      grant.  There can be no assurance that the SFAS 123(R) amounts      will ever be realized.  The maximum amount of options granted to a      single director is 15,000 per year. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (2) | At      December 31, 2008, the aggregate number of option awards outstanding was:       Mr. Julian C. Baker – 123,035 shares; Mr. Eran Broshy – 90,309      shares; Mr. Stewart Hen – 82,542 shares; Mr. John L. LaMattina – 12,324      shares; Dr. Craig Saxton – 175,747 shares and Dr. John Simon –      102,754 shares.                                                                                                                                                                                                                                                                                                                                                                                                                                                                 |

----

| Name      and Address of Beneficial Owner                           |   | Shares      Ownedincluding      OptionsExercisable      within60      days of April 16, 2009 |   | Right      to AcquireBeneficial      Ownershipunder      Options Exercisablewithin      60 days of April 16, 2009 |   | Percent      ofCommon      Stockowned |
|---------------------------------------------------------------------|--------|----------------------------------------------------------------------------------------------|--------|-------------------------------------------------------------------------------------------------------------------|--------|---------------------------------------|
| Warburg      Pincus & Co. (1)                                   |   | 13,571,411                                                                                   |   |                                                                                                              |   | 19.9                                  |
| 466      Lexington Avenue                                           |   |                                                                                         |   |                                                                                                              |   |                                  |
| New      York, NY 10017                                        |   |                                                                                         |   |                                                                                                              |   |                                  |
| Andrew      H. Tisch (2)                                            |   | 947,108                                                                                      |   |                                                                                                              |   | 1.4                                   |
| Daniel      R. Tisch (2)                                            |   | 947,108                                                                                      |   |                                                                                                              |   | 1.4                                   |
| James      S. Tisch (2)                                        |   | 947,108                                                                                      |   |                                                                                                              |   | 1.4                                   |
| Thomas      J. Tisch (2)                                            |   | 947,108                                                                                      |   |                                                                                                              |   | 1.4                                   |
| Joan      H. Tisch (2)                                              |   | 24,100                                                                                       |   |                                                                                                              |   | *                                     |
| Four-Fourteen      Partners, LLC (2)                           |   | 2,800,004                                                                                    |   |                                                                                                              |   | 4.1                                   |
| 667      Madison Avenue East 52nd Street                            |   |                                                                                         |   |                                                                                                              |   |                                  |
| New      York, NY 10065                                        |   |                                                                                         |   |                                                                                                              |   |                                  |
| Tang      Capital Management (3)                               |   | 4,578,980                                                                                    |   |                                                                                                              |   | 6.7                                   |
| 441      Eastgate Mall                                              |   |                                                                                         |   |                                                                                                              |   |                                  |
| San      Diego, CA 92121                                       |   |                                                                                         |   |                                                                                                              |   |                                  |
| Columbia      Wanger Asset Management, L.P.  (4)          |   | 3,660,000                                                                                    |   |                                                                                                              |   | 5.4                                   |
| 227      West Monroe Street,Suite      3000                         |   |                                                                                         |   |                                                                                                              |   |                                  |
| Chicago,      IL 60606                                         |   |                                                                                         |   |                                                                                                              |   |                                  |
| All      current officers and directors as a group(10 persons) |   | 10,266,421                                                                                   |   | 1,300,745                                                                                                         |   | 14.9                                  |
| Stephen      R. Davis                                               |   | 512,825                                                                                      |   | 369,553                                                                                                           |   | *                                     |
| Julian      C. Baker (5)                                       |   | 8,402,139                                                                                    |   | 122,033                                                                                                           |   | 12.2                                  |
| Eran      Broshy                                                    |   | 89,307                                                                                       |   | 89,307                                                                                                            |   | *                                     |
| Stewart      Hen                                                    |   | 82,166                                                                                       |   | 82,166                                                                                                            |   | *                                     |
| John      LaMattina                                                 |   | 11,948                                                                                       |   | 11,948                                                                                                            |   | *                                     |
| Thomas      A. Pitler                                               |   | 256,111                                                                                      |   | 187,796                                                                                                           |   | *                                     |
| Craig      Saxton                                                   |   | 199,620                                                                                      |   | 174,620                                                                                                           |   | *                                     |
| John      Simon                                                     |   | 410,246                                                                                      |   | 101,752                                                                                                           |   | *                                     |
| Kenneth      J. Sprenger                                            |   | 146,499                                                                                      |   | 86,570                                                                                                            |   | *                                     |
|  Srdjan      Stankovic                                         |   | 155,560                                                                                      |   | 75,000                                                                                                            |   | *                                     |

----

|  *  | Less      than 1% of the outstanding shares of common stock.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |
|---------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (1)           | Based      on a Schedule 13D/A filed with the SEC on April 14 2008, reporting      beneficial ownership as of April 11, 2008, by Warburg Pincus Private      Equity VIII, L.P., (“WP VII LP”), Warburg Pincus LLC, the manager of each      Investor defined below (“WP LLC”), Warburg Pincus Partners LLC, (WP      Partners LLC”) , Warburg Pincus & Co., the sole general partner      of WP VIII and the managing member of WP Partners (“WP”) and Messrs.      Charles R. Kaye and Joseph P. Landy, each a Managing General Partner of WP      and Co-President and Managing Member of WP LLC.  Due to their      respective relationships with Warburg and each other, each of WP IX LLC,      WP LLC, WPP LLC, WP, Mr. Kaye and Mr. Landy may be deemed to      beneficially own, and each  report shared voting and shared      dispositive power with respect to, an aggregate of 8,571,429 shares of      Common Stock (the “WP Shares”), excluding 7,499,973 shares of Common Stock      issuable upon the exchange of the 192,307 shares of Series A Preferred      Stock and exercise of Warrants to purchase Common Stock beneficially owned      by Warburg Pincus Private Equity VIII, L.P. reported as beneficially owned      in the Schedule 13D/A, The WP Shares include the holdings of Warburg      Pincus Netherlands Private Equity VIII C.V. I (“WPNPE”) and WP-WPVIII      Investors L.P. (WPVIII).  Each of WP VII LP, WP LLC, WP, WP      Partners LLC, Mr. Kaye and Mr. Landy disclaim beneficial      ownership of all shares of the Common Stock except to the extent of any      indirect pecuniary interest therein.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
| (2)           | Based      on Schedule 13G/A with the SEC on January 30, 2009, reporting beneficial      ownership as of December 31, 2008, by Andrew H. Tisch, Daniel R. Tisch,      James H. Tisch, Thomas J. Tisch and Joan H. Tisch.  The shares      held by Andrew H. Tisch include 694,803 shares held directly by Andrew H.      Tisch, 126,153 shares held by Andrew H. Tisch 1995 Issue Trust 1, and      126,152 shares held by Andrew H. Tisch 1995 Issue Trust 2 as to which      Daniel R. Tisch has sole voting and sole dispositive power. The      shares held by Daniel R. Tisch include 694,803 shares held directly by      Daniel R. Tisch and 252,305 shares held by the Daniel R. Tisch 1999 Issue      Trust as to which Daniel R. Tisch has sole voting and sole dispositive      power.  The shares held by James H. Tisch include 694,803 held      directly by James H. Tisch and 252,305 shares  held by the James      S. Tisch 1995 Issue Trust as to which James S. Tisch has sole voting and      sole dispositive power.  Joan H. Tisch holds 24,100 shares as to      which she has sole voting and dispositive power.  The shares      held by Thomas J. Tisch include 694,803 held directly by Thomas J. Tisch      and 252,305 shares held by the Thomas J. Tisch 1994 Issue Trust and      2,800,004 shares held by Four-Fourteen Partners, LLC as to which Thomas J.      Tisch has sole voting and sole dispositive power.  By virtue of      their status as trustees of the respective Trusts referred to above, each      of Andrew H. Tisch, Daniel R. Tisch, James S. Tisch and Thomas J. Tisch      may be deemed to be the beneficial owner of securities held by those      trusts.  By virtue of his status as manager of Four-Fourteen      Partners, LLC, Thomas J. Tisch may be deemed to be the beneficial owner of      securities owned by Four-Fourteen Partners, LLC.   Each of      Andrew H. Tisch, Daniel R. Tisch, James S. Tisch, Joan H. Tisch and Thomas      J. Tisch disclaims that he or she and any other person or persons in fact      constitute a "group" for purposes of Section 13(d)(3) of the Securities      Exchange Act of 1934, as amended, or Rule 13d-5 thereunder or that he is      the beneficial owner of, or has a pecuniary interest in, any securities      owned by any other person.  The address of each person is 667      Madison Ave., 7th Floor, New York, NY 10021, except for Daniel R.      Tisch, whose address is 500 Park Ave., New York,      NY 10022. |
| (3)           | Based      on a Schedule 13G/A filed with the SEC on February 17, 2009 which reported      beneficial ownership as of December 13, 2008 for Tang Capital Partners, LP      and Tang Capital Management as the general partner of Tang Capital      Partners.  Tang Capital  Management, Tang capital      Partners and Kevin C. Tang share voting and dispositive power over the      4,578,980 shares.  Kevin C. Tang is manager of Tang Capital      Management.  Mr Tang disclaims beneficial ownership of all      shares reported herein except to the extent of his pecuniary interest      therein.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
| (4)           | Based      on a Schedule 13G/A filed with the SEC on January 27, 2009 reporting      beneficial ownership as of December 31, 2008 by Columbia Wanger Asset      Management, L.P., which acts as an investment adviser and  is      deemed to have sole voting and sole dispositive power with respect to      these shares.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |
| (5)           | Based      on a Schedule 13D/A filed with the SEC on April 15, 2008, reporting      beneficial ownership as of April 11, 2008 by Julian C. Baker (“J. Baker”)      and Felix J. Baker (“F. Baker”).  Includes 16,200 shares held      directly by J. Baker as to which he has sole voting as dispositive power,      4,692 shares held directly by F. Baker as to which he has sole voting and      dispositive power and 210,556 shares held by Baker/Tisch Investments,      L.P., 230,162 shares held by Baker Bros. Investments, L.P., 203,190 shares      held by Baker Bros. Investments II, L.P., 2,195,509 shares held by Baker      Biotech Fund I, L.P., 2,307,661 shares held by Baker Brothers Life      Sciences, L.P., 58,500 shares held by FBB Associates as to which J. Baker      and F. Baker have shared voting and shared dispositive      power.  Excluding 1,956,825 held by Baker Biotech Fund I, L.P.,      181,116 shares held by Baker Bros Investments II, L.P., 205,140 shares      held by Baker Bros Investments, L.P., 2,056,743 shares held by Baker      Brothers Life Sciences, L.P. and 187,668 shares held by Baker Tisch      Investments, L.P. issuable upon the exchange of shares of Series A      Preferred Stock and exercise of Warrants to purchase Common Stock reported      as beneficially owned in the Schedule 13D/A.  By virtue of their      ownership of entities that have power to control the investment decisions      of the limited partnerships listed above, J. Baker and F. Baker may each      be deemed to be the beneficial owners of the shares owned by such      entities.  J. Baker and F. Baker are also sole partners of FBB      Associates, a general partnership and as such may be deemed to be      beneficial owners of shares owned by FBB Associates.  The      address for J. Baker, F. Baker and each entity listed above is 667 Madison      Avenue, 17th Floor, New York,NY 10065.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         |

----

----

| Name      of Investor                              | Number      of Units Purchased | Shares      of Common Stock Issuable Upon Exchange of Series A Exchangeable Preferred      Stock | Shares      of Common Stock Issuable Upon Exercise of Warrants |
|----------------------------------------------------|--------------------------------|--------------------------------------------------------------------------------------------------|----------------------------------------------------------------|
| Baker      Bros. Advisors, LLC                     | 117,628                        | 3,058,328                                                                                        | 1,529,164                                                      |
| Warburg      Pincus LLC                            | 192,307                        | 4,999,982                                                                                        | 2,499,991                                                      |
| Four-Fourteen      Partners, L.L.C.  (1) | 96,154                         | 2,500,004                                                                                        | 1,250,002                                                      |
| John      Simon, Ph.D.                             | 9,615                          | 249,990                                                                                          | 124,995                                                        |

ITEM 14. PRINCIPAL ACCOUNTING FEES ANDSERVICES

----

----

| EXHIBITNUMBER | DESCRIPTION                                                                                                                                                                                                                                                                                                                                                                                                    |
|---------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 3.1           | Restated      Certificate of Incorporation, filed July 7, 1994 (incorporated by      reference to Exhibit 4.1 to Registration Statement No. 33-81268 on Form      S-8).                                                                                                                                                                                                                                        |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 3.2           | By-Laws,      as amended (incorporated by reference to Exhibit 3.6 to the Company's Form      10-K for the fiscal year ended December 31, 1993).                                                                                                                                                                                                                                                               |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 3.3           | Restated      Certificate of Incorporation, as amended effective June 8, 2007      (incorporated by reference to Exhibit 3.1 to the Company’s Form 10-Q for      the quarterly period ended June 30, 2007).                                                                                                                                                                                              |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 3.4           | Amendment      to Restated Certificate of Incorporation, effective July 31, 2008      (incorporated by reference to Exhibit 3.1 to the Company’s Form 8-K filed      on July 31, 2008).                                                                                                                                                                                                                  |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 3.5           | Certificate      of Designations, Number, Voting Powers, Preferences and Rights of Series A      Exchangeable Preferred Stock of Neurogen Corporation, filed April 10, 2008      (incorporated by reference to Exhibit 4.2 to the Company’s Form 8-K filed      on April 11, 2008).                                                                                                                      |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 4.1           | Registration      Rights Agreement, dated April 7, 2008, by and between Neurogen Corporation      and certain selected institutional investors listed on Exhibit A thereof      (incorporated by reference to Exhibit 4.1 to the Company’s Form 8-K filed      on April 11, 2008).                                                                                                                       |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.1          | Neurogen      Corporation 1993 Omnibus Incentive Plan, as amended (incorporated by      reference to Exhibit 10.3 to the Company's Form 10-K for the fiscal year      ended December 31, 1993).                                                                                                                                                                                                                |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.2          | Form      of Stock Option Agreement currently used in connection with the grant of      options under Neurogen Corporation 1993 Omnibus Incentive Plan      (incorporated by reference to Exhibit 10.4 to the Company's Form 10-K for      the fiscal year ended December 31, 1993).                                                                                                                           |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.3          | Neurogen      Corporation 1993 Non-Employee Directors Stock Option Program (incorporated      by reference to Exhibit 10.5 to the Company's Form 10-K for the fiscal      year ended December 31, 1993).                                                                                                                                                                                                       |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.4          | Form      of Stock Option Agreement currently used in connection with the grant of      options under Neurogen Corporation 1993 Non-Employee Directors Stock      Option Program (incorporated by reference to Exhibit 10.6 to the Company's      Form 10-K for the fiscal year ended December 31, 1993).                                                                                                      |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.5          | Form      of Proprietary Information and Inventions Agreement (incorporated by      reference to Exhibit 10.31 to Registration Statement No. 33-29709 on Form      S-1).                                                                                                                                                                                                                                       |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.6          | Collaborative      Research Agreement and License and Royalty Agreement between the Company      and Pfizer Inc, dated as of January 1, 1992 (CONFIDENTIAL TREATMENT      REQUESTED) (incorporated by reference to Exhibit 10.35 to the Company's      Form 10-K for the fiscal year ended December 31, 1991).                                                                                                 |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.7          | Collaborative      Research Agreement and License and Royalty Agreement between the Company      and Pfizer Inc, dated as of July 1, 1994 (CONFIDENTIAL TREATMENT      REQUESTED) (incorporated by reference of Exhibit 10.1 to the Company's      Form 10-Q for the quarterly period ended June 30,1994).                                                                                                     |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.8          | Stock      Purchase Agreement between the Company and Pfizer dated as of July 1, 1994      (incorporated by reference to Exhibit 10.2 to the Company's Form 10-Q for      the quarterly period ended June 30, 1994).                                                                                                                                                                                           |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.9          | Collaboration      and License Agreement and Screening Agreement between the Company and      Schering-Plough Corporation (CONFIDENTIAL TREATMENT REQUESTED)      (incorporated by reference to Exhibit 10.1 to the Company's Form 8-K dated      July 28, 1995).                                                                                                                                              |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.10         | Collaborative      Research Agreement between the Company and Pfizer dated as of November 1,      1995 (CONFIDENTIAL TREATMENT REQUESTED) (incorporated by reference to      Exhibit 10.1 of the Company's Form 8-K dated November 1,      1995).                                                                                                                                                              |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.11         | Development      and Commercialization Agreement between the Company and Pfizer dated as of      November 1, 1995 (incorporated by reference to Exhibit 10.2 of the      Company's Form 8-K dated November 1, 1995).                                                                                                                                                                                           |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.12         | Stock      Purchase Agreement between the Company and Pfizer dated as of November 1,      1995 (incorporated by reference to Exhibit 10.3 of the Company's Form 8-K      dated November 1, 1995).                                                                                                                                                                                                              |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.13         | Stock      Purchase Agreement dated as of November 25, 1996 between American Home      Products Corporation, acting through its Wyeth-Ayerst Laboratories      Division, and Neurogen Corporation (CONFIDENTIAL TREATMENT REQUESTED)      (incorporated by reference to Exhibit 10.1 of the Company's Form 8-K dated      March 31, 1997).                                                                     |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.14         | Technology      agreement between the Company and Pfizer Inc, dated as of June 15, 1999      (CONFIDENTIAL TREATMENT REQUEST) (Incorporated by reference to Exhibit      10.27 to the Company's Form 10-Q for the quarterly period ended June 30,      1999).                                                                                                                                                  |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.15         | Neurogen      Corporation 2000 Non-Employee Directors Stock Option Program (incorporated      by reference to Exhibit 10.31 to the Company's Form 10-Q for the quarterly      period ended June 30, 2000).                                                                                                                                                                                                     |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.16         | Form      of the Non-Qualified Stock Option Agreement currently used in connection      with the grant of options under the Neurogen Corporation 2000 Non-Employee      Directors Stock Option Program (incorporated by reference to Exhibit 10.32      to the Company's Form 10-Q for the quarterly period ended June 30,      2000).                                                                         |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.17         | Registration      Rights Agreement dated as of June 26, 2000 between the Company and the      Purchasers listed on Exhibit A thereto (incorporated by reference to      Exhibit 10.33 to the Company's Form 10-Q for the quarterly period ended      June 30, 2000).                                                                                                                                           |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.18         | Amended      and Restated Neurogen Corporation 2001 Stock Option Plan, as amended and      restated effective September 4, 2001 (incorporated by reference to Exhibit      10.29 to the Company's Form 10-Q for the quarterly period ended September      30, 2001).                                                                                                                                           |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.19         | Form      of Incentive Stock Option Agreement currently used in connection with the      grant of options under the Amended and Restated Neurogen Corporation 2001      Stock Option Plan (incorporated by reference to Exhibit 10.30 to the      Company's Form 10-Q for the quarterly period ended September 30,      2001).                                                                                 |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.20         | Form      of the Non-Qualified Stock Option Agreement currently used in connection      with the grant of options under the Amended and Restated Neurogen      Corporation 2001 Stock Option Plan (incorporated by reference to Exhibit      10.31 to the Company's Form 10-Q for the quarterly period ended September      30, 2001).                                                                         |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.21         | Form      of Neurogen Special Committee Stock Option Plan (incorporated by reference      to Exhibit 10.32 to the Company's Form 10-Q for the quarterly period ended      September 30, 2001).                                                                                                                                                                                                                 |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.22         | Collaboration      and License Agreement dated as of December 11, 2001 between the Company      and Aventis Pharmaceuticals Inc. (CONFIDENTIAL TREATMENT REQUESTED)      (incorporated by reference to Exhibit 10.35 to the Company's Form 10-K/A2      for the period ended December 31, 2001).                                                                                                               |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.23         | Modification      Agreement dated as of December 1, 2000 between Neurogen Properties LLC and      Connecticut Innovations, Incorporated (incorporated by reference to      Exhibit 10.36 to the Company's Form 10-KA/3 for the period ended December      31, 2001).                                                                                                                                           |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.24         | Construction      Loan Agreement dated as of October 22, 1999 between Neurogen Properties      LLC and Connecticut Innovations, Incorporated (incorporated by reference      to Exhibit 10.37 to the Company's Form 10-KA/3 for the period ended      December 31, 2001).                                                                                                                                      |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.25         | Commercial      Term Note dated as of December 21, 2001 held by the Company and payable to      Webster Bank (incorporated by reference to Exhibit 10.38 to the Company's      Form 10-KA/3 for the period ended December 31, 2001).                                                                                                                                                                           |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.26         | Commercial      Loan Agreement dated as of December 21, 2001 between Webster Bank and the      Company (incorporated by reference to Exhibit 10.39 to the Company's Form      10-KA/3 for the period ended December 31, 2001).                                                                                                                                                                                 |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.27         | Form      of Proprietary Information and Inventions Agreement (incorporated by      reference to Exhibit 10.2 to the Company's Form 10-Q for the quarterly      period ended June 30, 2002).                                                                                                                                                                                                                   |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.28         | Amendments      to the Neurogen Corporation Non-Employee Directors Stock Option Program      (incorporated by reference to Exhibit 10.1 to the Company's Form 10-Q for      the quarterly period ended September 30, 2002).                                                                                                                                                                                    |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.29         | Collaboration      and License Agreement dated as of November 24, 2003 between the Company      and Merck Sharp & Dohme Limited (CONFIDENTIAL TREATMENT REQUESTED)      (incorporated by reference to Exhibit 10.43 to the Company's Form 10-K for      the period ended December 31, 2003).                                                                                                               |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.30         | Stock      Purchase Agreement dated as of November 24, 2003 between the Company and      Merck Sharp & Dohme Limited (CONFIDENTIAL TREATMENT REQUESTED)      (incorporated by reference to Exhibit 10.43 to the Company's Form 10-K for      the period ended December 31, 2003).                                                                                                                          |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.31         | Securities      Purchase Agreement by and between Neurogen Corporation, Warburg Pincus      Private Equity VIII, L.P., entities affiliated with Baker Brothers      Investments and entities affiliated with the Tisch family (incorporated by      reference to Exhibit 99.1 to the Company's Form 8-K dated March 26,      2004).                                                                            |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.32         | Letter      Agreement dated as of March 26, 2004, amending the securities purchase      dated March 19, 2004, by and between Neurogen Corporation, Warburg Pincus      Private Equity VIII, L.P., entities affiliated with Baker Brothers      Investments and entities affiliated with the Tisch family (incorporated by      reference to Exhibit 99.1 to the Company's Form 8-K dated March 26,      2004). |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.33         | Neurogen      Corporation Code of Business Conduct and Ethics, April 27, 2004      (incorporated by reference to Exhibit 14.1 of the Company's Form 10-K/A      dated April 29, 2004).                                                                                                                                                                                                                         |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.34         | Neurogen      Corporation 2000 Non-Employee Directors Stock Option Program, as amended      (incorporated by reference to Appendix B to the Registrant's Definitive      Proxy Statement on Schedule 14A (File No. 000-18311) filed on July 12,      2004).                                                                                                                                                    |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.35         | Amended      and Restated Neurogen Corporation 2001 Stock Option Plan, as amended      (incorporated by reference to Appendix D to the Registrant's Definitive      Proxy Statement on Schedule 14A (File No. 000-18311) filed on July 12,      2004).                                                                                                                                                         |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.36         | Neurogen      Corporation Audit Committee Charter (May 19, 2004) (incorporated by      reference to Appendix E to the Company's Form DEF 14A dated July 12,      2004).                                                                                                                                                                                                                                        |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.37         | Form      of Non-Qualified Stock Option Agreement for the Neurogen Corporation 2000      Non-Employee Directors Stock Option Program (incorporated by reference to      Exhibit 10.1 to the Company's Form 8-K dated December 20,      2004).                                                                                                                                                                  |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.38         | Form      of Incentive Stock Option Agreement for the Amended and Restated Neurogen      Corporation 2001 Stock Option Plan (incorporated by reference to Exhibit      10.2 to the Company's Form 8-K dated December 20,2004).                                                                                                                                                                                 |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.39         | Form      of Non-Qualified Stock Option Agreement for the Amended and Restated      Neurogen Corporation 2001 Stock Option Plan (incorporated by reference to      Exhibit 10.3 to the Company's Form 8-K dated December 20,      2004).                                                                                                                                                                       |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.40         | Form      of Restricted Share Award Agreement for the Amended and Restated Neurogen      Corporation 2001 Stock Option Plan (incorporated by reference to Exhibit      10.4 to the Company's Form 8-K dated December 20,2004).                                                                                                                                                                                 |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.41         | Amended      and Restated Neurogen Corporation 2001 Stock Option Plan (as amended and      restated) (incorporated by reference to Appendix B to the Registrant's      Definitive Proxy Statement on Schedule 14A (File No. 000-18311) filed on      May 19, 2005).                                                                                                                                            |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.42         | Neurogen      Corporation Audit Committee Charter (As Amended on July 20, 2004)      (incorporated by reference to Appendix C to the Company's Form DEF 14A      dated May 19, 2005).                                                                                                                                                                                                                          |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.43         | License      Agreement between Neurogen Corporation and Wyeth Pharmaceuticals dated as      of November 22, 2006 (CONFIDENTIAL TREATMENT REQUESTED) (incorporated by      reference to Exhibit 10.47 to the Company’s Form 10-K filed on March 15,      2007).                                                                                                                                           |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.44         | Neurogen      Corporation 2000 Non-Employee Directors Stock Option Program, as amended      (incorporated by reference to Appendix B to the Registrant's Definitive      Proxy Statement on Schedule 14A (File No. 000-18311) filed on May 1,      2006).                                                                                                                                                      |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.45         | Amended      and Restated Neurogen Corporation 2001 Stock Option Plan, as amended      (incorporated by reference to Appendix D to the Registrant's Definitive      Proxy Statement on Schedule 14A (File No. 000-18311) filed on May 26,      2006).                                                                                                                                                          |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.46         | Amended      and Restated Employment Agreement between Neurogen Corporation and Stephen      R. Davis dated as of May 8, 2007 (incorporated by reference to Exhibit      10.1 to the Company’s Form 10-Q for the quarterly period ended March 31,      2007).                                                                                                                                            |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.47         | Amended      and Restated Employment Agreement between Neurogen Corporation and Stephen      Uden dated as of May 8, 2007 (incorporated by reference to Exhibit 10.2 to      the Company’s Form 10-Q for the quarterly period March 31,      2007).                                                                                                                                                      |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.48         | Amended      and Restated Employment Agreement between Neurogen Corporation and Alan      Hutchison dated as of May 8, 2007 (incorporated by reference to Exhibit      10.3 of the Company’s Form 10-Q for the quarterly period March 31,      2007).                                                                                                                                                    |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.49         | Employment      Agreement between Neurogen Corporation and James Krause dated as of May 8,      2007 (incorporated by reference to Exhibit 10.4 of the Company’s Form 10-Q      for the quarterly period March 31, 2007).                                                                                                                                                                                |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.50         | Employment      Agreement between Neurogen Corporation and Bertrand Chenard dated as of      May 8, 2007 (incorporated by reference to Exhibit 10.5 of the Company’s      Form 10-Q for the quarterly period March 31, 2007).                                                                                                                                                                            |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.51         | Amended      and Restated Neurogen Corporation 2001 Stock Option Plan, as amended      (incorporated by reference to Appendix B of the Registrant's Definitive      Proxy Statement on Schedule 14A (File No. 000-18311) filed on May 14,      2007).                                                                                                                                                          |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.52         | Securities      Purchase Agreement, dated April 7, 2008, between Neurogen Corporation and      certain selected institutional investors listed in Exhibit A thereof      (incorporated by reference to Exhibit 10.1 of the Company's Form 8-K dated      April 11, 2008).                                                                                                                                      |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.53         | Employment      Contract between the Company and Srdjan Stankovic, dated as of April 14,      2008 (incorporated by reference to Exhibit 10.1 to the Company's Form 8-K      dated April 24, 2008).                                                                                                                                                                                                            |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.54    |  Employment      Contract between the Company and Thomas A. Pitler dated as of March 30,      2009 (incorporated by reference to Exhibit 10.54 to the Company’s Form      10-K dated March 31, 2009).                                                                                                                                                                                               |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.55    |  Employment      Contract between the Company and Kenneth Sprenger dated as of March 30,      2009 (incorporated by reference to Exhibit 10.55 to the Company’s Form      10-K dated March 31, 2009).                                                                                                                                                                                               |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 10.56         |  Employment      Contract between the Company and George Maynard dated as of March 30, 2009      (incorporated by reference to Exhibit 10.56 to the Company’s Form 10-K      dated March 31, 2009).                                                                                                                                                                                                 |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 21.1          | Subsidiary      of the registrant (incorporated by reference to Exhibit 21.1 to the      Company's Form 10-K for the fiscal year ended December 31,      1999).                                                                                                                                                                                                                                                |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 23.1          | Consent      of PricewaterhouseCoopers LLP, Independent Registered Public Accounting      Firm (incorporated by reference to Exhibit 23.1 to the Company’s Form 10-K      dated March 31, 2009).                                                                                                                                                                                                         |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 24.1          | Powers      of Attorney of Julian C. Baker, Eran Broshy, Stewart Hen, John L.      LaMattina, Craig Saxton, and John Simon (incorporated by reference to      Exhibit 24.1 to the Company’s Form 10-K dated March 31,    2009).                                                                                                                                                                     |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 31.1          | Certification      Pursuant to Section 302 of the Sarbanes-Oxley Act of  2002.                                                                                                                                                                                                                                                                                                                                 |
|          |                                                                                                                                                                                                                                                                                                                                                                                                           |
| 31.2          | Certification      Pursuant to Section 302 of the Sarbanes-Oxley Act of  2002.                                                                                                                                                                                                                                                                                                                                 |

----

| NEUROGEN      CORPORATION                                                                                                |
|--------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                     |
| By: /s/ THOMAS A.      PITLER                                                                                            |
|                                                                                                                     |
| Thomas      A. PitlerSenior      Vice President and Chief Business and Financial OfficerDated:      April 30, 2009  |

| SIGNATURE                                  |   | TITLE                                                   |   | DATE                |
|--------------------------------------------|--------|---------------------------------------------------------|--------|---------------------|
|                                       |   |                                                    |   |                |
|                                       |   |                                                    |   |                |
| *                                          |   |                                                    |   |                |
| Craig      Saxton                          |   | Chairman      of the Board and Director                 |   | April      30, 2009 |
|                                       |   |                                                    |   |                |
| /s/      STEPHEN R. DAVIS                  |   |                                                    |   |                |
| Stephen      R. Davis                      |   | President      and Chief Executive Officer and Director |   | April      30, 2009 |
|                                       |   |                                                    |   |                |
|                                       |   |                                                    |   |                |
| *                                          |   |                                                    |   |                |
| Julian      C. Baker                       |   | Director                                                |   | April      30, 2009 |
|                                       |   |                                                    |   |                |
| *                                          |   |                                                    |   |                |
| Eran      Broshy                           |   | Director                                                |   | April      30, 2009 |
|                                       |   |                                                    |   |                |
| *                                          |   |                                                    |   |                |
| Stewart      Hen                           |   | Director                                                |   | April      30, 2009 |
|                                       |   |                                                    |   |                |
|  *                                    |   |                                                    |   |                |
| John      L. LaMattina                     |   | Director                                                |   | April      30, 2009 |
|                                       |   |                                                    |   |                |
|                                       |   |                                                    |   |                |
| *                                          |   |                                                    |   |                |
| John      Simon                            |   | Director                                                |   | April      30, 2009 |
|                                       |   |                                                    |   |                |
| * By:  /s/      THOMAS A. PITLER |
| Thomas      A. Pitler,Attorney-in-Fact     |