18834 Federal Register / Vol. 77, No. 60 / Wednesday, March 28, 2012 / Notices 

inventors designed a rapid mass 

spectrometry device using direct impact 

spark ionization source for microbial 

analytes identification via spectral 

pattern recognition. The device design 

includes a rapid mass spectrometer 

suitable for analyzing microbiological 

samples that was earlier used to analyze 

low volatile organic compounds. The 

device employs a solid needle for 

electrode discharge. It includes a gear 

plate that introduces stainless steel pins 

carrying bacterial samples. The pins 

also act as counter electrodes and are 

targeted by controlled arcs. The small 

custom-made glass cylinder that is 

meant to shut out oxygen and prevent 

the introduction of ambient moisture 

into the analyte is unique from other 

DISI device. The examination revealed 

enormous peak intensity and spectral 

information with normal ionization 

mode on the same instrument. This 

device can be employed in fields such 

as pathogen determination in clinical 

settings, QA/QC (of drugs, food or 

cosmetic ingredients), continuous 

monitoring of (airborne) Biological 

Warfare Agents and the like. 

Potential Commercial Applications: 

• Pathogen detection, 

• QA/QC (of drugs, food or cosmetic 

ingredients), 

• Continuous monitoring of (airborne) 

Biological Warfare Agents and the like. 

Competitive Advantages: 

• Rapid, specific, sensitive and 

reproducible identification of 

microbiological analytes. 

• Systematic acquisition of 

reproducible spectra among same 

bacterial species. 

• Whole cell analysis of food-borne 

pathogens is rapid, safer and microreliable. 

• Characteristic mass spectra 

obtained and reproduced for food-borne 

pathogens. 

• Unique DISI device with gas 

cylinder chamber. 

Development Stage: 

• Prototype. 

• In vitro data available. 

Inventors: Peter Alusta, Cameron 

Dorey, Ryan Parker, Dan A. Buzatu, Jon 

G. Wilkes (all of FDA/NCTR). 

Intellectual Property: HHS Reference 

No. E–258–2011/0—U.S. Patent 

Application No. 13/271,182 filed 11 Oct 

2011. 

Related Technologies: 

• HHS Reference No. E–169–2000/ 

0—U.S. Patent Application No. 09/ 

975,530 filed 10 Oct 2001. 

• HHS Reference No. E–259–2011/ 

0—U.S. Provision Application No. 61/ 

564,926 filed 30 Nov 2011. 

Licensing Contact: Michael A. 

Shmilovich, Esq., CLP; 301–435–5019; 

shmilovm@mail.nih.gov. 

Collaborative Research Opportunity: 

The NCTR/FDA inventors are seeking 

statements of capability or interest from 

parties interested in collaborative 

research to further develop, evaluate or 

commercialize this device. For 

collaboration opportunities, please 

contact Alice Y. Welch, Ph.D. at 

Alice.Welch@fda.hhs.gov. 

Method of Treating Hepatitis C Virus 

Infection With a Small Molecule CHK2 

Inhibitor 

Description of Technology: DNA 

damage sensors such as Checkpoint 

Kinase 2 (Chk2) are key regulators of the 

cellular DNA damage response that 

limits cell-cycle progression in response 

to DNA damage. It has been reported 

that these DNA damage sensors also 

play a key role in Hepatitis C virus 

(HCV) replication. The subject 

technology are small molecule CHK2 

kinase inhibitors that have been shown 

to have promising activity against HCV 

replication. The compounds were 

discovered by high throughput 

screening of chemical libraries with 

more than 150,000 compounds. These 

novel compounds can potentially be 

used in combination with other antiHCV drugs or interferon and represent 

a novel target for treating HCV. In vitro 

antiviral assay data, as well as 

preliminary in vitro and in vivo 

pharmokinetic data are available upon 

request. 

Potential Commercial Applications: 

The subject technology can potentially 

be developed into anti-HCV 

therapeutics, particularly in 

combination with other anti-HCV 

therapeutics. 

Competitive Advantages: The subject 

technology represents a novel and 

promising target for treating HCV 

infection and thus, has the potential to 

increase the efficacy of other HCV 

antivirals that directly target HCV in a 

multi-drug formulation. Furthermore, 

since the subject technology targets a 

cellular protein necessary for HCV 

replication and not the virus itself, the 

emergence of viral resistance against the 

subject technology could be low or more 

delayed. 

Development Stage: 

• Early-stage. 

• Pre-clinical. 

• In vitro data available. 

• In vivo data available (animal). 

Inventors: Yves G. Pommier, Robert H. 

Shoemaker, Dominic A. Scudiero, 

Andrew G. Jobson, David S. Waugh, 

George T. Lountos (all of NCI) 

Publications: 

1. Jobson AG, et al. Identification of 

a Bis-guanylhydrazone [4,4′- 

Diacetyldiphenylureabis(guanylhydrazone); NSC 109555] as a 

novel chemotype for inhibition of Chk2 

kinase. Mol Pharmacol 2007 

Oct;72(4):876–884. [PMID 17616632] 

2. Jobson AG, et al. Cellular inhibition 

of checkpoint kinase 2 (Chk2) and 

potentiation of camptothecins and 

radiation by the novel Chk2 inhibitor 

PV1019 [7-nitro-1H-indole-2-carboxylic 

acid {4-[1-(guanidinohydrazone)-ethyl]- 

phenyl}-amide]. J Pharmacol Exp Ther. 

2009 Dec;331(3):816–826. [PMID 

19741151] 

3. Lountos GT, et al. Crystal structure 

of checkpoint kinase 2 in complex with 

NSC 109555, a potent and selective 

inhibitor. Protein Sci. 2009 

Jan;18(1):92–100. [PMID 19177354] 

4. Lountos GT, et al. X-ray structures 

of checkpoint kinase 2 in complex with 

inhibitors that target its gatekeeperdependent hydrophobic pocket. FEBS 

Lett. 2011Oct 20;585(20):3245–3249. 

[PMID 21907711] 

5. Lountos GT, et al. Structural 

characterization of inhibitor complexes 

with checkpoint kinase 2 (Chk2), a drug 

target for cancer therapy. J Struct Biol. 

2011 Dec;176(3):292–301. [PMID 

21963792] 

Intellectual Property: HHS Reference 

No. E–224–2011/0—U.S. Provisional 

Patent Application No. 61/551,742 filed 

26 Oct 2011. 

Related Technology: HHS Reference 

No. E–211–2005/0—U.S. Patent 

Application No. 11/989,737 filed 29 Jan 

2008, with corresponding applications 

in Europe, Canada, and Australia. 

Licensing Contact: Kevin W. Chang, 

Ph.D.; 301–435–5018; 

changke@mail.nih.gov. 

Dated: March 22, 2012. 

Richard U. Rodriguez, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health. 

[FR Doc. 2012–7419 Filed 3–27–12; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HOMELAND 

SECURITY 

Federal Emergency Management 

Agency 

[Internal Agency Docket No. FEMA–4057– 

DR; Docket ID FEMA–2012–0002] 

Kentucky; Amendment No. 5 to Notice 

of a Major Disaster Declaration 

AGENCY: Federal Emergency 

Management Agency, DHS. 

ACTION: Notice. 

SUMMARY: This notice amends the notice 

of a major disaster declaration for the 


tkelley on DSK3SPTVN1PROD with NOTICES
Federal Register / Vol. 77, No. 60 / Wednesday, March 28, 2012 / Notices 18835 

Commonwealth of Kentucky (FEMA– 

4057–DR), dated March 6, 2012, and 

related determinations. 

DATES: Effective Date: March 20, 2012. 

FOR FURTHER INFORMATION CONTACT: 

Peggy Miller, Office of Response and 

Recovery, Federal Emergency 

Management Agency, 500 C Street SW., 

Washington, DC 20472, (202) 646–3886. 

SUPPLEMENTARY INFORMATION: The notice 

of a major disaster declaration for the 

Commonwealth of Kentucky is hereby 

amended to include the following areas 

among those areas determined to have 

been adversely affected by the event 

declared a major disaster by the 

President in his declaration of March 6, 

2012. 

Ballard County for Public Assistance. 

Johnson, Kenton, Larue, Pendleton, 

Trimble, and Wolfe Counties for Public 

Assistance (already designated for Individual 

Assistance). 

The following Catalog of Federal Domestic 

Assistance Numbers (CFDA) are to be used 

for reporting and drawing funds: 97.030, 

Community Disaster Loans; 97.031, Cora 

Brown Fund; 97.032, Crisis Counseling; 

97.033, Disaster Legal Services; 97.034, 

Disaster Unemployment Assistance (DUA); 

97.046, Fire Management Assistance Grant; 

97.048, Disaster Housing Assistance to 

Individuals and Households in Presidentially 

Declared Disaster Areas; 97.049, 

Presidentially Declared Disaster Assistance— 

Disaster Housing Operations for Individuals 

and Households; 97.050, Presidentially 

Declared Disaster Assistance to Individuals 

and Households—Other Needs; 97.036, 

Disaster Grants—Public Assistance 

(Presidentially Declared Disasters); 97.039, 

Hazard Mitigation Grant. 

W. Craig Fugate, 

Administrator, Federal Emergency 

Management Agency. 

[FR Doc. 2012–7396 Filed 3–27–12; 8:45 am] 

BILLING CODE 9111–23–P 

DEPARTMENT OF HOMELAND 

SECURITY 

Federal Emergency Management 

Agency 

[Internal Agency Docket No. FEMA–4057– 

DR; Docket ID FEMA–2011–0001] 

Kentucky; Amendment No. 4 to Notice 

of a Major Disaster Declaration 

AGENCY: Federal Emergency 

Management Agency, DHS. 

ACTION: Notice. 

SUMMARY: This notice amends the notice 

of a major disaster declaration for the 

Commonwealth of Kentucky (FEMA– 

4057–DR), dated March 6, 2012, and 

related determinations. 

DATES: Effective Date: March 16, 2012. 

FOR FURTHER INFORMATION CONTACT: 

Peggy Miller, Office of Response and 

Recovery, Federal Emergency 

Management Agency, 500 C Street SW., 

Washington, DC 20472, (202) 646–3886. 

SUPPLEMENTARY INFORMATION: The notice 

of a major disaster declaration for the 

Commonwealth of Kentucky is hereby 

amended to include the Public 

Assistance program for the following 

areas among those areas determined to 

have been adversely affected by the 

event declared a major disaster by the 

President in his declaration of March 6, 

2012. 

Grant, Laurel, Lawrence, Magoffin, Martin, 

Menifee, and Morgan Counties for Public 

Assistance (already designated for Individual 

Assistance). 

The following Catalog of Federal Domestic 

Assistance Numbers (CFDA) are to be used 

for reporting and drawing funds: 97.030, 

Community Disaster Loans; 97.031, Cora 

Brown Fund; 97.032, Crisis Counseling; 

97.033, Disaster Legal Services; 97.034, 

Disaster Unemployment Assistance (DUA); 

97.046, Fire Management Assistance Grant; 

97.048, Disaster Housing Assistance to 

Individuals and Households in Presidentially 

Declared Disaster Areas; 97.049, 

Presidentially Declared Disaster Assistance— 

Disaster Housing Operations for Individuals 

and Households; 97.050, Presidentially 

Declared Disaster Assistance to Individuals 

and Households—Other Needs; 97.036, 

Disaster Grants—Public Assistance 

(Presidentially Declared Disasters); 97.039, 

Hazard Mitigation Grant. 

W. Craig Fugate, 

Administrator, Federal Emergency 

Management Agency. 

[FR Doc. 2012–7399 Filed 3–27–12; 8:45 am] 

BILLING CODE 9111–23–P 

DEPARTMENT OF HOMELAND 

SECURITY 

Federal Emergency Management 

Agency 

[Docket ID FEMA–2012–0003; Internal 

Agency Docket No. FEMA–B–1246] 

Proposed Flood Hazard 

Determinations 

AGENCY: Federal Emergency 

Management Agency, DHS. 

ACTION: Notice. 

SUMMARY: Comments are requested on 

proposed flood hazard determinations, 

which may include additions or 

modifications of any Base Flood 

Elevation (BFE), base flood depth, 

Special Flood Hazard Area (SFHA) 

boundary or zone designation, or 

regulatory floodway on the Flood 

Insurance Rate Maps (FIRMs), and 

where applicable, in the supporting 

Flood Insurance Study (FIS) reports for 

the communities listed in the table 

below. The purpose of this notice is to 

seek general information and comment 

regarding the preliminary FIRM, and 

where applicable, the FIS report that the 

Federal Emergency Management Agency 

(FEMA) has provided to the affected 

communities. The FIRM and FIS report 

are the basis of the floodplain 

management measures that the 

community is required either to adopt 

or to show evidence of having in effect 

in order to qualify or remain qualified 

for participation in the National Flood 

Insurance Program (NFIP). In addition, 

the FIRM and FIS report, once effective, 

will be used by insurance agents and 

others to calculate appropriate flood 

insurance premium rates for new 

buildings and the contents of those 

buildings. 

DATES: Comments are to be submitted 

on or before June 26, 2012. 

ADDRESSES: The Preliminary FIRM, and 

where applicable, the FIS report for 

each community are available for 

inspection at both the online location 

and the respective Community Map 

Repository address listed in the tables 

below. Additionally, the current 

effective FIRM and FIS report for each 

community are accessible online 

through the FEMA Map Service Center 

at www.msc.fema.gov for comparison. 

You may submit comments, identified 

by Docket No. FEMA–B–1246, to Luis 

Rodriguez, Chief, Engineering 

Management Branch, Federal Insurance 

and Mitigation Administration, FEMA, 

500 C Street SW., Washington, DC 

20472, (202) 646–4064, or (email) 

Luis.Rodriguez3@fema.dhs.gov. 

FOR FURTHER INFORMATION CONTACT: Luis 

Rodriguez, Chief, Engineering 

Management Branch, Federal Insurance 

and Mitigation Administration, FEMA, 

500 C Street SW., Washington, DC 

20472, (202) 646–4064, or (email) 

Luis.Rodriguez3@fema.dhs.gov; or visit 

the FEMA Map Information eXchange 

(FMIX) online at 

www.floodmaps.fema.gov/fhm/ 

fmx_main.html. 

SUPPLEMENTARY INFORMATION: FEMA 

proposes to make flood hazard 

determinations for each community 

listed below, in accordance with section 

110 of the Flood Disaster Protection Act 

of 1973, 42 U.S.C. 4104, and 44 CFR 

67.4(a). 

These proposed flood hazard 

determinations, together with the 

floodplain management criteria required 

by 44 CFR 60.3, are the minimum that 

are required. They should not be 

construed to mean that the community 


tkelley on DSK3SPTVN1PROD with NOTICES