### United States Environmental Protection Agency , Washington, D.C. 20460 DATA CALL - IN RESPONSE OMB Approval 2070 - 0174 INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information reques ted on this form. Use additional sheet(s) if necessary. 1. Company Name and Address 2. Case # and Name 250 Mevinphos Active Ingredient # and n ame 015801 Mevinphos 3. Date and Type of DCI and Number GENERIC FFDCA DCI

Item 9, e nter the appropriate numerical re sponse for each guideline study that you intend to support : 1 = Developing Data, 2 = Submitting an Existing Study, 3 = Upgrading a Study, 4 = Citing an Existing Study. (For 860.1500 or 860.1520, concerning a specific commodity, you may enter 5 = Will not support). 4. Guideline Requirement Number 5. Study title Footnotes to Data Requirements 6a. Protocol 6 b . Progress Reports 7. Test Substance 8. Time

Frame (Months) 9. Recipient

Response 1 2 3 860.1200 Directions for Use No ---- 12 860.1500 Crop Field Trial - Broccoli Yes TEP 24 860.1500 Crop Field Trial - Cabbage Yes TEP 24 860.1500 Crop Field Trial - Cauliflower Yes TEP 24 860.1500 Crop Field Trial - Celery Yes TEP 24 860.1500 Crop Field Trial - Grapes Yes TEP 24 860.1500 Crop Field Trial - Lettuce Yes TEP 24 860.1500 Crop Field Trial - Peas Yes TEP 24 860.1500 Crop Field Trial - Peppers Yes TEP 24 860.1500 Crop Field Trial - Spinach Yes TEP 24 860.1500 Crop Field Trial - Squas h, summer Yes TEP 24 860.1500 Crop Field Trial - Strawberries Yes TEP 24 860.1500 Crop Field Trial - Tomatoes Yes TEP 24 860.1520 Processing Study - Tomatoes Yes TEP 24 870.6300 Comparative Cholinesterase Assay Yes TGAI 12 870.7800 Immunotoxicity No TGAI 12 10 . Certification : I certify that the statements made o n this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, i mprisonment or both under applicable law. Signature of Individual or Signature and Title of Company’s Authorized Representative ________________

_______ _________

__ ________ ___ 11. Date 12. Name of Company or Individual Contact (Include e - mail address) 13. Phone NumberFailure to Submit the 90 - Day Response : If a submission of a response to U.S. EPA to comply with the Data Call - In requirements of the final order is not submitted within 90 days after publication of the final order in the Federal Register, EPA may revoke the appropriate tolerance or tolerances associated with the active ingredient named in Item 2. 90 - Day Response Instructions: It em 1, enter your company or individual name and address. It em 6a identifies any study protocol report timef rame, if required by the Agency. It em 6 b identifies study progress report timeframes, if required by the Agency. It em 7 identifies the code associated with the substance that must be used for testing : PAI = pure active ingredient, TGAI = technical grade active ingredient, EUP = end-use product, MP = manufacturing -use product, MET = metabolites, TEP = typical end -use product, PAI/M = pure active ingredient and metabolites, TEP/MET = typical end -use product and metabolites, DEGR = degradates, IMP = impurities, PAIRA = pure active ingredient radiolabeled, PAIRA/M = pure active ingredient radiolabeled and metabolites, PAIRA/PM = pure active ingredient radiolabeled and plant metabolites, TGAI/TEP = technical grade active ingredient or typical end -use product, PAI/PAIRA = pure active ingredient or pure active ingredient radiolabeled, MP/TGAI = manufacturing -use product and technical grade active ingredient, TGAI/PAIRA = technical active ingredient or pure active ingredient radiolabeled, TGAI/PAI = technical grade active ingredient or pure active ingredient, TEP/PAI/M = typical end -use product or pure active ingredient and metabolites . It em 8 identifies timeframe s for EPA’s re ceipt of data. Timeframes begin on the date of publication in the Federal Register of th e final order for the Data Call - In. It em 9, enter the appropriate numerical response for each guideline study that you intend to support: 1 = Developing Data, 2 = Submitting an Existing Study ( that has not been submitted previously to EPA by anyone ) , 3 = Upgrading a Study ( classified by EPA as partially acceptable and upgradeable ) , 4 = Citing an Existing Study ( that EPA has classified as acceptable or an existing study that has been submitted but not reviewed by the Agency) . Note, for guidelines 860.1500 or 860.1520, concerning a specific commodity, you may enter 5 = Will not support . It em 10, sign the certification statement

– it must be signed by an authorized representative of your company and the person signing must include his/her title. It em 11, enter the date of signature. It em 12, enter the name of the person EPA should contact with questions regarding your response (Include e - mail address) . It em 13, enter the telephone number of your company contact. Failure to Comp ly with Response Commitment and/or Data Requirements: Events that may be the basis for revocation of tolerances associated with the active ingredient named in Item 2 include, but are not limited to the following: No person submits on the required schedule: (1) an acceptable proposed or final protocol when such is required to be submitted to the Agency for review, (2) an adequate progress report on a study as required by the final order, (3) acceptable data as required by the final order, (4) supportable certifications as to the condit ions of submitted data, where required by the final order and where no other cited or submitted study meets the data requirements the study was intended to fulfill.

### United States Environmental Protection Agency , Washington, D.C. 20460

FOOTNOTES AND KEY DE FINITIONS FOR GUIDELINE REQUIREMENTS

Case # and Name 250 Mevinphos , GENERIC FFDCA DCI 

### OMB Approval 2070 - 0174 Footnotes: 860.1200 Directions for use (No footnotes for this study) 860.1500 Crop field trials 1. Required for residential outdoor uses on food crops if the corresponding agricultural use is not approved or the residential use is expected to produce higher residue s based on the label directions. 2. A residue method, storage stability data, and crop field trials are required for the nonfood cr op tobacco (green, freshly harvested). Depending on the level of residues found on the green tobacco, additional data may be required on cured/dried tobacco and pyrolysis products. 3. Required for indoor uses which are direct postharvest treatments of raw agricultural commodities (e.g., fungicidal axes or stored grain fumigants). 4. Crop field trials are required to establish tolerances on rotational crops when quantifiable residues of concern are observed in the field rotational crops study. 5. Not require d for an exemption from a tolerance provided that dietary exposure estimates are not needed due to low toxicity or that theoretical estimates of exposure are adequate to assess dietary risk. 860.1520 Processed food or feed 1. Required if indoor use could result in pesticide residues in or on food or feed. 2. Data on the nature and level of residues in processed food/feed are required if residues could potentially concentrate on processing thus requiring the establishment of a separate tolerance higher than that of the raw agricultural commodity. 3. Not required for an exemption from a tolerance provided that dietary exposure estimates are not needed due to low toxicity or that theoretical estimates of exposure are adequate to assess dietary risk. 870.6300 Developmental neurotoxicity 1. An information - based approach to testing is preferred, which utilizes the best available knowledge on the chemical (hazard, pharmacokinetic, or mechanistic data) to determine whether a standard guideline study, an enhanced gu ideline study, or an alternative study should be conducted to assess potential hazard to the developing animal, or in some cases to support a waiver for such testing. Registrants should submit any alternative proposed testing protocols and supporting scientific rationale to the Agency prior to study initiation. 2. Study required using a weight - of - evidence approach considering: (i) The pesticide causes treatment - related neurological effects in adult animal studies (i.e ., clinical signs of neurotoxicity, neuropathology, functional or behavioral effects). (ii) The pesticide causes treatment - related neurological effects in developing animals, following pre - and postnatal exposure ( i.e. , nervous system malformations or neuropathy, brain weight changes in offsp ring, functional or behavioral changes in the offspring). (iii) The pesticide elicits a causative association between exposures and adverse neurological effects in human epidemiologic al studies. (iv) The pesticide evokes a mechanism that is associated with adverse effects on the development of the nervous system (e.g., SAR relationship to known neurotoxicants, altered neurorecept or or neurotransmitter responses). 3. The use of a combined study that utilizes the 2

–generation reproduction study in rodents as a basic protocol for the addition of other endpoints or functional assessments in the immature animal is encouraged. 870.7800 Immunotoxicity (No footnotes for this study)