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EPA REGISTRATION DIVISION COMPANY NOTICE OF FILING FOR PESTICIDE PETITIONS PUBLISHED IN THE FEDERAL REGISTER EPA Registration Division contact: William Cutchin, Inert Ingredient Assessment Branch (IIAB) 703 - 305 - 7990 TEMPLATE: Akzo Nobel Surface Chemistry, LLC IN - 10544 EPA has received an amendment to the Notice of Filing (NOF) published i n the Federal Register of July 19, 2013 ( Vol. 78, No. 139 FR 4311) (FRL - 9392 - 9) , where EPA issued a notice pursuant to section 408 of FFDCA, 21 U.S.C. 346a, announcing the filing of a pesticide petition ( IN - 10544 ). The petitioner, Spring Trading Company,10805 W. Timberwagon Cir., Spring, TX 77380 - 4030, on behalf of Akzo Nobel Surface Chemistry , LLC; 525 West Van Buren, Chicago, IL 60607 - 3823 is requesting a change in the 40 CFR sections under which the requested tolerance exemptions would be established from 180.920, 180. 930, or 180. 960 to 180.910, 180. 930, 180. 940 (a) or 180. 960. The petitioner is now requesting , pursuant to section 408(d) of the Federal Food, Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a(d), to amend 40 CFR part 180 to amend the exemption from the requirement of a tolerance for [alpha] - alkyl - [omega] - hydroxypoly (oxypropylene) and/or poly (oxyethylene) polyme rs where the alkyl chain contains a minimum of six carbons under 40 CFR 180.910, 180. 930, 180. 940 (a) in or o n the raw agricultural commodities after harvest or growing crops , animals and food contact surface sanitizing solutions and [alpha] - alkyl - [omega] - h ydroxypoly (oxypropylene) and/or poly (oxyethylene) polymers where the alkyl chain contains a minimum of six carbons, minimum number average molecular weight (in amu) 1,100 under 40 CFR 180.960 to include : CAS # Chemical Name 67254 - 71 - 1 Alcohols, C10 - 12, ethoxylated 161025 - 22 - 5 Alcohols, C 10 - 16, ethoxylated 68409 - 59 - 6 Alcohols, C11 - 14, branched and linear, ethoxylated 160901 - 20 - 2 Alcohols, Cl 1 - 14 - iso - , CIS - rich, propoxylated 159653 - 49 - 3 Alcohols, C12 - 13, branched and linear, ethox ylated 160901 - 19 - 9 Alcohols, C12 - 14, propoxylated 103331 - 86 - 8 Alcohols, C12 - 14 - secondary, ethoxylated propoxylated 126950 - 62 - 7 Alcohols, C12 - 14 - secondary, propoxylated 74499 - 34 - 6 Alcohols, C12 - 15, propoxylated2

CAS # Chemical Name 161025 - 21 - 4 Alcohols, C12 - 16, ethoxylated 176022 - 76 - 7 Alcohols, C12 - 16, propoxylated 68603 - 20 - 3 Alcohols, C12 - 19, ethoxylated 68526 - 95 - 4 Alcohols, C12 - 20, ethoxylated propoxylated 64425 - 86 - 1 Alcohols, C13 - 15, ethoxylated 139626 - 71 - 4 Alcohols, C14 - 100, ethoxylated 152231 - 44 - 2 Alcohols, C14 - 15, ethoxylated propoxylated 120944 - 68 - 5 Alcohols, C14 - 15 - branched and linear, ethoxylated 157707 - 41 - 0 Alcohols, C14 - 16, ethoxylated 288260 - 45 - 7 Alcohols, C14 - 16, ethoxylated 287935 - 46 - 0 Alcohols, C14 - 18 and C16 - 18 - unsatd., propoxylated 126646 - 02 - 4 Alcohols, C14 - 18 and C16 - 18 - unsarurated, ethoxylated 954108 - 36 - 2 Alcohols, C14 - 20, propoxylated 71011 - 10 - 4 Alcohols, C14 - 26, ethoxylated 121617 - 09 - 2 Alcohols, C16 - 18, propoxylated 69227 - 20 - 9 Alcohols, C16 - 22, ethoxylated 116810 - 32 - 3 Alcohols, C18 - 22 - alkyl, ethoxylated 79771 - 03 - 2 Alcohols, C18 - 32, propoxylated 67763 - 08 - 0 Alcohols, C20 - 28, ethoxylated 68439 - 48 - 5 Alcohols, C20 - 30, ethoxyiated 72066 - 65 - 0 Alcohols, C7 - 17, propoxylated 68991 - 48 - 0 Alcohols, C7 - 21, ethoxylated 303176 - 75 - 2 Alcohols, C7 - 9 - branched, C8 - rich, ethoxylated propoxylated 116810 - 33 - 4 Alcohols, C8 - 12 - alkyl, ethoxylated propoxylated 157707 - 43 - 2 Alcohols, C8 - 18, ethoxylated 68954 - 94 - 9 Alcohols, C8 - 20, ethoxylated 160901 - 09 - 7 Alcohols, C9 - 11, branched and linear, ethoxylated 102782 - 43 - 4 Alcohols, C9 - 11, branched and linear, ethoxylated propoxylated 68920 - 69 - 4 Alcohols, C9 - 11, propoxylated 154518 - 36 - 2 Alcohols, C9 - 11 - iso - , C10 - rich, ethoxylated propoxylated 157627 - 88 - 8 A lcohols, C9 - 15, ethoxylated 116810 - 31 - 2 Alcohols, cetyl oleyl, ethoxylated, propoxylated 68439 - 53 - 2 Alcohols, lanolin, propoxylated 103819 - 03 - 0 Alcohols, tallow, ethoxylated propoxylated 70955 - 07 - 6 Alcohols, tallow, propoxylated 74432 - 13 - 6 Alcohol (C6 - C18) ethoxylated 68439 - 30 - 5 Qxirane, 2 - methyl - , polymer with oxirane, 8 - methyhionyl ether 9038 - 29 - 3 Oxirane, 2 - methyl - , polymer with oxirane, decyl ether 68238 - 81 - 3 Oxirane, 2 - methyl - , polymer with oxirane, dodecyl ether 68409 - 58 - 5 Oxirane , 2 - methyl - , polymer with oxirane, hexadecyl octadecyl ether 68238 - 82 - 4 Oxirane, 2 - methyl - , polymer with oxirane, hexyl ether 63303 - 00 - 4 Oxirane, 2 - methyl - , polymer with oxirane, mono(4 - dodecylphenyl)

ether 57455 - 38 - 6 Oxirane , 2 - methyl - , polymer with oxirane, mono(dodecylphenyl) ether3

CAS # Chemical Name 57497 - 74 - 2 Oxirane, 2 - methyl - , polymer with oxirane, mono(isooctylphenyl) ether 70955 - 69 - 0 Oxirane, 2 - methyl - , polymer with oxirane, mono(octylphenyl) ether,

branched 37311 - 00 - 5 Oxirane, 2 - methyl - , polymer with oxirane, monododecyl ether 37311 - 01 - 6 Oxirane, 2 - methyl - , polymer with oxirane, monohexadecyl ether 52232 - 09 - 4 Oxirane, 2 - methyl - , polymer with oxirane, monohexyl ether 73018 - 31 - 2 Oxirane, 2 - methyl - , polymer with oxirane, monoisooctadecyl ether 9038 - 43 - 1 Oxirane, 2 - methyl - , polymer with oxirane, monooctadecyl ether 63303 - 01 - 5 Oxirane, 2 - methyl - , polymer with oxirane, monopentadecyl ether 37311 - 04 - 9 Oxirane, 2 - methyl - , polymer with oxirane, monotetradecyl ether 65150 - 8 1 - 4 Oxirane, 2 - methyl - , polymer with oxirane, monotridecyl ether 63658 - 45 - 7 Oxirane, 2 - methyl - , polymer with oxirane, pentadecyl ether 139381 - 39 - 8 Oxirane, methyl - , polymer with oxirane, butyl octyl ether 72484 - 69 - 6 Oxirane, methyl - , polymer with oxirane, mono(2 - decyltetradecyl)

ether 59112 - 62 - 8 Oxirane, methyl - , polymer with oxirane, mono - (9Z) - 9 - octadecenyl

ether 50861 - 66 - 0 Oxirane, methyl - , polymer with oxirane, monoisotridecyl ether 103657 - 84 - 7 Oxirane, methyl - , polymer with oxirane, monononyl ether 103657 - 85 - 8 Oxirane, methyl - , polymer with oxirane, monoundecyl ether 26401 - 47 - 8 Poly(oxy - l,2 - ethanediyl), a - (4 - dodecylphenyl) - w - hydroxy 39278 - 93 - 8 Poly(oxy - l,2 - ethanediyl), a - (dioctylphenyl) - w - hydroxy 9004 - 87 - 9 Poly(oxy - 1,2 - ethanediyl), a - (isooctylphenyl) - w - hydroxy 68987 - 90 - 6 Poly(oxy - l,2 - ethanediyl), a - (octylphenyl) - w - hydroxy - , branched 26403 - 74 - 7 Poly(oxy - 1,2 - ethanediyl), a - (phenylmethyl) - w - hydroxy 9046 - 09 - 7 Poly(oxy - l,2 - ethanediyl), a - (tributylphenyl) - w - hydroxy 67784 - 96 - 7 Poly(oxy - l,2 - ethanediyl), a - [(9Z) - l - oxo - 9 - octadecen - l - yl] - w - hydroxy - ,

C12 - 15 - alkyl ethers 25190 - 05 - 0 Poly(oxy - l ,2 - ethanediyl), a - 9 - octadecen - 1 - yl - w - hydroxy 26636 - 39 - 5 Poly(oxy - l,2 - ethanediyl), a - eicosyl - w - hydroxy 64415 - 24 - 3 Poly(oxy - 1,2 - ethanediyl), a - hexadecadien - 1 - yl - w - hydroxy 65104 - 72 - 5 Poly(oxy - 1,2 - ethanediyl), a - hexadecen - 1 - yl - w - hydroxy 9040 - 05 - 5 Poly(oxy - l,2 - ethanediyl), a - octadecenyl - w - hydroxy 27252 - 75 - 1 Poly(oxy - l,2 - ethanediyl), a - octyl - w - hydroxy 288095 - 59 - 0 Poly(oxy - l,2 - ethanediyl), a - phenyl - w - hydroxy - , ar - C8 - 12 - alkyl derivs. 64415 - 25 - 4 Poly(oxy - l,2 - ethanediyl), a - tetradecen - 1 - yl - w - hydroxy 9035 - 85 - 2 Poly[oxy(methyl - l,2 - ethanediyl)], a - hexadecyl - w - hydroxy 72108 - 90 - 8 Poly[oxy(methyl - 1,2 - ethanediyl)], a - isotridecyl - w - hydroxy 25231 - 21 - 4 Poly[oxy(methyl - l,2 - ethanediyl)], a - octadecyl - w - hydroxy 62648 - 50 - 4 Poly[oxy(methyl - l,2 - ethanediyl)], a - pentadecyl - w - hydroxy 63793 - 60 - 2 Poly[oxy(methyl - l ,2 - ethanediyl)], a - tetradecyl - w - hydroxy The petitioner does not expect that the addition of these CAS#s to result in additional exposure or risk.4 EPA has determined that the petition contains data or information regarding the elements set forth in section 408 (d)(2) of FDDCA; however, EPA has not fully evaluated the sufficiency of the submitted data at this time or whether the data supports granting of the petition. Additional data may be needed before EPA rules on the petition. A. Residue Chemistry 1. Plant metabolism. Information regarding plant met abolism is not required since the Agency is establishing an exemption from the requirement of a tolerance . 2. Analytical method. An analytical method is not required for enforcement purposes since the Agency is establishing an exemption from the requirement of a tolerance without any numerical limitation. 3. Magnitude of residues. AkzoNobel is petitioning the agency to amend an existing exemption from the requirement of a tolerance. Therefore information regarding the nature and magnitude of chemical residues resulting from the use of this inert ingredient is not required. B. Toxicological Profile EPA has evaluated the available toxicity data and considered its validity, completeness, and reliability as well as the relationship of the result s of the studies to human risk. EPA has also considered available information concerning the variability of the sensitivities of major identifiable subgroups of consumers including infants and children. 1. Acute toxicity. The [ alpha] - alkyl - [omega] - hydroxypoly (oxypropylene) and/or poly (oxyethylene) polymers where the alkyl chain contains a minimum of six carbons , and a - alkyl - w - hydroxypoly (oxypropylene) and/or poly (oxyethylene) polymers ( AAAs ) are not acutely toxic by the oral and dermal routes of exposure under normal use conditions. Concentrated materials are generally moderate to severe eye and skin irritants and may be skin sensitizers. There is no evidence of mutagenicity in the Ames assay (bacterial strains) . 2. Genotoxicty. The AAA's showed no evidence of mutagenicity, or chromosome aberration. 3. Reproductive and developmental toxicity. No reproductive or developmental/offspring toxicity was observed. It is generally accepted that increased ethoxylation decreases lipophilicity resul ting in decreased absorption and decreased toxicity. The lower molecular weight AAAs would be expected to be absorbed and distributed more readily than higher molecular weight AAAs and therefore to potentially be more toxic. The representative ethoxylated compounds tested have the lowest weight percent ethoxylation and lowest molecular weight of the series and are potentially the most bioavailable of the series. Although metabolism data are not available, the major metabolic pathway for AAA surfactants is e xpected to include the hyd rolysis of ether5

linkage to the corresponding alkyl alcohol and polyalkoxylate (POE or POE/POP) gr oup wh ich subsequently undergoes oxidative degradation and/or excretion. 4. Subchronic toxicity. Following subchronic exposure to rats and dogs, decreases in body weight and food consumption were observed, but nonspecific target organ toxicity or neurotoxicity was seen. No effects were detected in a functional observational battery (FOB) or motor activity assessment. In a 90 - day dermal toxicity study with AAA surfactant, no systemic toxicity was observed at doses up to 125 mg/kg/day (the highest dose tested). 5. Chronic toxicity. There is no evidence that the AAA surfactants are carcinogenic. The Agency used a qualitati ve structure activity relationship (SAR) database, DEREK Version 11, to determine if there were structural alerts. No structural alerts were identified. In addition, there was little concern about any of the postulated metabolites having greater toxicity t han the parent compounds. Specific information on the studies received and the nature of the adverse effects caused by AAA, as well as, the no - observed - adverse - effect - level (NOAEL) and the lowest observed adverse - effect - level (LOAEL) from the toxicity st udies can be found at http://www.regulations.gov in document Alky l Alcohol Alkoxylates (AAA - JITF CST 1 Inert Ingredient). Human Health Risk Assessment to Support Proposed Exemption from the Requirement of a Tolerance When Used as an Inert Ingredient in Pesticide For mulations at pp 13 - 20 and pp 61 - 75 in docket ID number EPAHQ - OPP - 2009 - 0145. ] 6. Endocrine disruption . FQPA requires EPA to develop a screening program to determine whether certain substances, including all pesticide chemicals (both inert and active ingredients), "may have an effect in humans that is similar to an effect produced by a naturally occurring estrogen, or such other endocrine effect..." EPA has been working with interested stakeholders to develop a screening and testing program as well as a priority setting scheme. As the Agency proceeds with implementation of this program, further testing of products containing AA A's for endocrine effects may be required. C. Aggregate Exposure 1. Dietary exposure. In examining aggregate exposure, section 408 of the FFDCA directs EPA to consider available information concerning exposures from the pesticide residue in food and all other non - occupational exposures, including drinking water from ground water or surface water and exposure thro ugh pesticide use in gardens, lawns, or buildings (residential and other indoor uses). EPA establishes exemptions from the requirement of a tolerance only in those cases where it can be demonstrated that the risks from aggregate exposure to pesticide chemical residues under reasonably foreseeable circumstances will pose no appreciable risks to human health. In orde r to determine the risks from a ggregate exposure to pesticide inert ingredients, the Agency considers the toxicity o f the inert in conjunction with possible exposure to residues of the inert ingredient through food, drinking water, and through other exposures that occur as a res ult o f pesticide use in residential settings. If EPA is6

able to determine that a finite tolera nce is not nec essary to ensure that there is a reasonable certainty that no harm will result from aggregate exposure to the inert ingredient, an exemption from the requirement of a tolerance may be established. The AAAs are used as inert ingredients in pesticide produ cts that are currently registered for uses that could result in intermediate - term residential exposure and the Agency has determined that it is appropriate to aggregate chronic exposure through food and water with intermediate - term residential exposures to the AAAs. EPA has concluded that the combined intermediate - term aggregated food, water, and residential exposures result in aggregate MOEs of 230 for both adult males and females, respectively. Adult residential exposure includes high - end post application dermal exposure from contact with treated pets. EPA has concluded that the combined intermediate - term aggregated food, water, and residential exposures result in an aggregate MOE of 1 10 for children. Children's residential exposure includes total combined pet exposure. As the level of concern is for MOEs that are lower than 100, these MOEs are not of concern. The Agency has used various screening - level models to estimate some of the existing levels of exposure and those that could occur as a result of est ablishing this tolerance exemption. D. Cumulative Effects We have not found a common mechanism of toxicity finding as to AAAs and any other substances. AAAs do not appear to produce a toxic metabolite produced by other substances. For the purposes of this requested tolerance action AAAs do not have a common mechanism of toxicity with other substances. E. Safety Determination 1. U.S. population. Based on these risk assessments, EPA concludes that there is a reasonable certainty that no harm will res ult to the general population or to infants and children from aggregate exposure to residues of the AAAs. 2. Infants and children . Based on these risk assessments, EPA concludes that there is a reasonable certainty that no harm will result to the general population or to infants and children from aggregate exposure to residues of the lower weight AAAs. F. International Tolerances AkzoNobel is not aware of any country requiring a tolerance fo r the AA As nor have any CODEX Maximum Residue Level s been established for any food crops at this time.