i

EPA REGISTRATION DIVISION COMPANY NOTICE OF FILING FOR 

PESTICIDE PETITIONS PUBLISHED IN THE FEDERAL REGISTER 

EPA Registration Division contact: William Cutchin, Inert Ingredient Assessment 

Branch (IIAB) 703-305-7990

TEMPLATE:

Akzo Nobel Surface Chemistry, LLC

IN-10544

EPA has received an amendment to the Notice of Filing (NOF) published in the 

Federal Register of July 19, 2013 (Vol. 78, No. 139 FR 4311) (FRL-9392-9), where 

EPA issued a notice pursuant to section 408 of FFDCA, 21 U.S.C. 346a, announcing the 

filing of a pesticide petition (IN-10544). The petitioner, Spring Trading Company,10805 

W. Timberwagon Cir., Spring, TX 77380-4030, on behalf of Akzo Nobel Surface 

Chemistry, LLC; 525 West Van Buren, Chicago, IL 60607-3823 is requesting a change in 

the 40 CFR sections under which the requested tolerance exemptions would be 

established from 180.920, 180.930, or 180.960 to 180.910, 180.930, 180.940(a) or 

180.960. 

The petitioner is now requesting, pursuant to section 408(d) of the Federal Food, 

Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 346a(d), to amend 40 CFR part 180 to 

amend the exemption from the requirement of a tolerance for [alpha]-alkyl-[omega]-

hydroxypoly (oxypropylene) and/or poly (oxyethylene) polymers where the alkyl chain 

contains a minimum of six carbons under 40 CFR 180.910, 180.930, 180.940(a) in or on 

the raw agricultural commodities after harvest or growing crops, animals and food 

contact surface sanitizing solutions and [alpha]-alkyl-[omega]-hydroxypoly 

(oxypropylene) and/or poly (oxyethylene) polymers where the alkyl chain contains a 

minimum of six carbons, minimum number average molecular weight (in amu) 1,100

under 40 CFR 180.960 to include:

CAS # Chemical Name

67254-71-1 Alcohols, C10-12, ethoxylated

161025-22-5 Alcohols, C10-16, ethoxylated

68409-59-6 Alcohols, C11 -14, branched and linear, ethoxylated

160901 -20-2 Alcohols, Cl 1-14-iso-, CIS-rich, propoxylated

159653-49-3 Alcohols, C12-13, branched and linear, ethoxylated

160901-19-9 Alcohols, C12-14, propoxylated

103331-86-8 Alcohols, C12-14-secondary, ethoxylated propoxylated

126950-62-7 Alcohols, C12-14-secondary, propoxylated

74499-34-6 Alcohols, C12-15, propoxylated
2

CAS # Chemical Name

161025-21-4 Alcohols, C12-16, ethoxylated

176022-76-7 Alcohols, C12-16, propoxylated

68603-20-3 Alcohols, C12-19, ethoxylated

68526-95-4 Alcohols, C12-20, ethoxylated propoxylated

64425-86-1 Alcohols, C13-15, ethoxylated

139626-71-4 Alcohols, C14-100, ethoxylated

152231-44-2 Alcohols, C14-15, ethoxylated propoxylated

120944-68-5 Alcohols, C14-15-branched and linear, ethoxylated

157707-41-0 Alcohols, C14-16, ethoxylated

288260-45-7 Alcohols, C14-16, ethoxylated

287935-46-0 Alcohols, C14-18 and C16-18-unsatd., propoxylated

126646-02-4 Alcohols, C14-18 and C16-18-unsarurated, ethoxylated

954108-36-2 Alcohols, C14-20, propoxylated

71011-10-4 Alcohols, C14-26, ethoxylated

121617-09-2 Alcohols, C16-18, propoxylated

69227-20-9 Alcohols, C16-22, ethoxylated

116810-32-3 Alcohols, C18-22-alkyl, ethoxylated

79771-03-2 Alcohols, C18-32, propoxylated

67763-08-0 Alcohols, C20-28, ethoxylated

68439-48-5 Alcohols, C20-30, ethoxyiated

72066-65-0 Alcohols, C7-17, propoxylated

68991-48-0 Alcohols, C7-21, ethoxylated

303176-75-2 Alcohols, C7-9-branched, C8-rich, ethoxylated propoxylated

116810-33-4 Alcohols, C8-12-alkyl, ethoxylated propoxylated

157707-43-2 Alcohols, C8-18, ethoxylated

68954-94-9 Alcohols, C8-20, ethoxylated

160901-09-7 Alcohols, C9-11, branched and linear, ethoxylated

102782-43-4 Alcohols, C9-11, branched and linear, ethoxylated propoxylated

68920-69-4 Alcohols, C9-11, propoxylated

154518-36-2 Alcohols, C9-11-iso-, C10-rich, ethoxylated propoxylated

157627-88-8 Alcohols, C9-15, ethoxylated

116810-31-2 Alcohols, cetyl oleyl, ethoxylated, propoxylated

68439-53-2 Alcohols, lanolin, propoxylated

103819-03-0 Alcohols, tallow, ethoxylated propoxylated

70955-07-6 Alcohols, tallow, propoxylated

74432-13-6 Alcohol (C6-C18) ethoxylated

68439-30-5 Qxirane, 2-methyl-, polymer with oxirane, 8-methyhionyl ether

9038-29-3 Oxirane, 2-methyl-, polymer with oxirane, decyl ether

68238-81-3 Oxirane, 2-methyl-, polymer with oxirane, dodecyl ether

68409-58-5 Oxirane, 2-methyl-, polymer with oxirane, hexadecyl octadecyl ether

68238-82-4 Oxirane, 2-methyl-, polymer with oxirane, hexyl ether

63303-00-4 Oxirane, 2-methyl-, polymer with oxirane, mono(4-dodecylphenyl) 

ether

57455-38-6 Oxirane, 2-methyl-, polymer with oxirane, mono(dodecylphenyl) ether
3

CAS # Chemical Name

57497-74-2 Oxirane, 2-methyl-, polymer with oxirane, mono(isooctylphenyl) ether

70955-69-0 Oxirane, 2-methyl-, polymer with oxirane, mono(octylphenyl) ether, 

branched

37311-00-5 Oxirane, 2-methyl-, polymer with oxirane, monododecyl ether

37311-01-6 Oxirane, 2-methyl-, polymer with oxirane, monohexadecyl ether

52232-09-4 Oxirane, 2-methyl-, polymer with oxirane, monohexyl ether

73018-31-2 Oxirane, 2-methyl-, polymer with oxirane, monoisooctadecyl ether

9038-43-1 Oxirane, 2-methyl-, polymer with oxirane, monooctadecyl ether

63303-01-5 Oxirane, 2-methyl-, polymer with oxirane, monopentadecyl ether

37311-04-9 Oxirane, 2-methyl-, polymer with oxirane, monotetradecyl ether

65150-81-4 Oxirane, 2-methyl-, polymer with oxirane, monotridecyl ether

63658-45-7 Oxirane, 2-methyl-, polymer with oxirane, pentadecyl ether

139381-39-8 Oxirane, methyl-, polymer with oxirane, butyl octyl ether

72484-69-6 Oxirane, methyl-, polymer with oxirane, mono(2-decyltetradecyl) 

ether

59112-62-8 Oxirane, methyl-, polymer with oxirane, mono-(9Z)-9-octadecenyl 

ether

50861-66-0 Oxirane, methyl-, polymer with oxirane, monoisotridecyl ether

103657-84-7 Oxirane, methyl-, polymer with oxirane, monononyl ether

103657-85-8 Oxirane, methyl-, polymer with oxirane, monoundecyl ether

26401-47-8 Poly(oxy-l,2-ethanediyl), a-(4-dodecylphenyl)-w-hydroxy39278-93-8 Poly(oxy-l,2-ethanediyl), a-(dioctylphenyl)-w-hydroxy9004-87-9 Poly(oxy-1,2-ethanediyl), a-(isooctylphenyl)-w-hydroxy68987-90-6 Poly(oxy-l,2-ethanediyl), a-(octylphenyl)-w-hydroxy-, branched

26403-74-7 Poly(oxy-1,2-ethanediyl), a-(phenylmethyl)-w-hydroxy9046-09-7 Poly(oxy-l,2-ethanediyl), a-(tributylphenyl)-w-hydroxy67784-96-7 Poly(oxy-l,2-ethanediyl), a-[(9Z)-l-oxo-9-octadecen-l-yl]-w-hydroxy-, 

C12-15-alkyl ethers

25190-05-0 Poly(oxy-l ,2-ethanediyl), a-9-octadecen-1-yl-w-hydroxy26636-39-5 Poly(oxy-l,2-ethanediyl), a-eicosyl-w-hydroxy64415-24-3 Poly(oxy-1,2-ethanediyl), a-hexadecadien-1-yl-w-hydroxy65104-72-5 Poly(oxy-1,2-ethanediyl), a-hexadecen-1-yl-w-hydroxy9040-05-5 Poly(oxy-l,2-ethanediyl), a-octadecenyl-w-hydroxy27252-75-1 Poly(oxy-l,2-ethanediyl), a-octyl-w-hydroxy288095-59-0 Poly(oxy-l,2-ethanediyl), a-phenyl-w-hydroxy-, ar-C8-12-alkyl derivs.

64415-25-4 Poly(oxy-l,2-ethanediyl), a-tetradecen-1-yl-w-hydroxy9035-85-2 Poly[oxy(methyl-l,2-ethanediyl)], a-hexadecyl-w-hydroxy72108-90-8 Poly[oxy(methyl-1,2-ethanediyl)], a-isotridecyl-w-hydroxy25231-21-4 Poly[oxy(methyl-l,2-ethanediyl)], a-octadecyl-w-hydroxy62648-50-4 Poly[oxy(methyl-l,2-ethanediyl)], a-pentadecyl-w-hydroxy63793-60-2 Poly[oxy(methyl-l ,2-ethanediyl)], a-tetradecyl-w-hydroxyThe petitioner does not expect that the addition of these CAS#s to result in 

additional exposure or risk.
4

EPA has determined that the petition contains data or information regarding the 

elements set forth in section 408 (d)(2) of FDDCA; however, EPA has not fully 

evaluated the sufficiency of the submitted data at this time or whether the data supports 

granting of the petition. Additional data may be needed before EPA rules on the petition.

A. Residue Chemistry

1. Plant metabolism. Information regarding plant metabolism is not required since 

the Agency is establishing an exemption from the requirement of a tolerance.

2. Analytical method. An analytical method is not required for enforcement 

purposes since the Agency is establishing an exemption from the requirement of a 

tolerance without any numerical limitation.

3. Magnitude of residues. AkzoNobel is petitioning the agency to amend an

existing exemption from the requirement of a tolerance. Therefore information regarding 

the nature and magnitude of chemical residues resulting from the use of this inert 

ingredient is not required.

B. Toxicological Profile

EPA has evaluated the available toxicity data and considered its validity, completeness, 

and reliability as well as the relationship of the results of the studies to human risk. EPA 

has also considered available information concerning the variability of the sensitivities of 

major identifiable subgroups of consumers including infants and children.

1. Acute toxicity. The [alpha]-alkyl-[omega]-hydroxypoly (oxypropylene) and/or 

poly (oxyethylene) polymers where the alkyl chain contains a minimum of six carbons, 

and a-alkyl-w-hydroxypoly (oxypropylene) and/or poly (oxyethylene) polymers (AAAs)

are not acutely toxic by the oral and dermal routes of exposure under normal use 

conditions. Concentrated materials are generally moderate to severe eye and skin irritants 

and may be skin sensitizers. There is no evidence of mutagenicity in the Ames assay 

(bacterial strains).

2. Genotoxicty. The AAA's showed no evidence of mutagenicity, or chromosome 

aberration.

3. Reproductive and developmental toxicity. No reproductive or

developmental/offspring toxicity was observed. It is generally accepted that increased 

ethoxylation decreases lipophilicity resulting in decreased absorption and decreased 

toxicity. The lower molecular weight AAAs would be expected to be absorbed and 

distributed more readily than higher molecular weight AAAs and therefore to potentially 

be more toxic. The representative ethoxylated compounds tested have the lowest weight 

percent ethoxylation and lowest molecular weight of the series and are potentially the 

most bioavailable of the series. Although metabolism data are not available, the major 

metabolic pathway for AAA surfactants is expected to include the hydrolysis of ether 
5

linkage to the corresponding alkyl alcohol and polyalkoxylate (POE or POE/POP) group 

which subsequently undergoes oxidative degradation and/or excretion.

4. Subchronic toxicity. Following subchronic exposure to rats and dogs, decreases 

in body weight and food consumption were observed, but nonspecific target organ 

toxicity or neurotoxicity was seen. No effects were detected in a functional observational 

battery (FOB) or motor activity assessment. In a 90-day dermal toxicity study with AAA 

surfactant, no systemic toxicity was observed at doses up to 125 mg/kg/day (the highest 

dose tested).

5. Chronic toxicity. There is no evidence that the AAA surfactants are

carcinogenic. The Agency used a qualitative structure activity relationship (SAR)

database, DEREK Version 11, to determine if there were structural alerts. No structural 

alerts were identified. In addition, there was little concern about any of the postulated 

metabolites having greater toxicity than the parent compounds.

Specific information on the studies received and the nature of the adverse effects caused 

by AAA, as well as, the no-observed-adverse-effect-level (NOAEL) and the lowestobserved adverse-effect-level (LOAEL) from the toxicity studies can be found at 

http://www.regulations.gov in document Alkyl Alcohol Alkoxylates (AAA -JITF CST 1 

Inert Ingredient). Human Health Risk Assessment to Support Proposed Exemption from 

the Requirement of a Tolerance When Used as an Inert Ingredient in Pesticide 

Formulations at pp 13-20 and pp 61-75 in docket ID number EPAHQ-OPP-2009-0145.]

6. Endocrine disruption. FQPA requires EPA to develop a screening program to 

determine whether certain substances, including all pesticide chemicals (both inert and

active ingredients), "may have an effect in humans that is similar to an effect produced by 

a naturally occurring estrogen, or such other endocrine effect..." EPA has been working 

with interested stakeholders to develop a screening and testing program as well as a 

priority setting scheme. As the Agency proceeds with implementation of this program, 

further testing of products containing AA A's for endocrine effects may be required.

C. Aggregate Exposure

1. Dietary exposure. In examining aggregate exposure, section 408 of the FFDCA 

directs EPA to consider available information concerning exposures from the pesticide 

residue in food and all other non-occupational exposures, including drinking water from 

ground water or surface water and exposure through pesticide use in gardens, lawns, or 

buildings (residential and other indoor uses).

EPA establishes exemptions from the requirement of a tolerance only in those cases

where it can be demonstrated that the risks from aggregate exposure to pesticide chemical 

residues under reasonably foreseeable circumstances will pose no appreciable risks to 

human health. In order to determine the risks from aggregate exposure to pesticide inert 

ingredients, the Agency considers the toxicity of the inert in conjunction with possible 

exposure to residues of the inert ingredient through food, drinking water, and through 

other exposures that occur as a result of pesticide use in residential settings. If EPA is 
6

able to determine that a finite tolerance is not necessary to ensure that there is a 

reasonable certainty that no harm will result from aggregate exposure to the inert 

ingredient, an exemption from the requirement of a tolerance may be established.

The AAAs are used as inert ingredients in pesticide products that are currently registered 

for uses that could result in intermediate-term residential exposure and the Agency has 

determined that it is appropriate to aggregate chronic exposure through food and water 

with intermediate-term residential exposures to the AAAs. EPA has concluded that the 

combined intermediate-term aggregated food, water, and residential exposures result in 

aggregate MOEs of 230 for both adult males and females, respectively. Adult residential 

exposure includes high-end post application dermal exposure from contact with treated 

pets. EPA has concluded that the combined intermediate-term aggregated food, water, 

and residential exposures result in an aggregate MOE of 110 for children. Children's 

residential exposure includes total combined pet exposure. As the level of concern is for 

MOEs that are lower than 100, these MOEs are not of concern.

The Agency has used various screening-level models to estimate some of the existing

levels of exposure and those that could occur as a result of establishing this tolerance

exemption.

D. Cumulative Effects

We have not found a common mechanism of toxicity finding as to AAAs and any 

other substances. AAAs do not appear to produce a toxic metabolite produced by other 

substances. For the purposes of this requested tolerance action AAAs do not have a 

common mechanism of toxicity with other substances. 

E. Safety Determination

1. U.S. population. Based on these risk assessments, EPA concludes that there is a 

reasonable certainty that no harm will result to the general population or to infants and 

children from aggregate exposure to residues of the AAAs.

2. Infants and children. Based on these risk assessments, EPA concludes that

there is a reasonable certainty that no harm will result to the general population or to 

infants and children from aggregate exposure to residues of the lower weight AAAs.

F. International Tolerances

AkzoNobel is not aware of any country requiring a tolerance for the AAAs nor 

have any CODEX Maximum Residue Levels been established for any food crops at this 

time.