LOAN
      PAYMENT AGREEMENT

    


    This
      Loan
      Payment Agreement is by and between Pressure BioSciences, Inc. (the “Company”),
      Resort Accommodations International, LLC (“RAI”), and Richard T. Schumacher
      (“Schumacher”). 

    


    WHEREAS,
      in
      January 2002, the Company pledged a $1,000,000 interest bearing deposit at
      Commerce Bank & Trust Company (the “Bank”) to secure its limited guaranty of
      loans in the aggregate amount of $2,418,000 from the Bank to RAI, an entity
      controlled by Schumacher, and, in connection therewith, the Company obtained
      a
      junior security interest in collateral, consisting of Schumacher’s shares of the
      Company’s common stock, pledged by Mr. Schumacher to the Bank;

    


    WHEREAS,
      in
      January 2003, the $1,000,000 held in the interest bearing deposit account
      pledged to the Bank was used by the Bank to satisfy its limited guaranty
      obligation to the Bank (the “Taking”); 

    


    WHEREAS,
      as a
      result of the Taking, the Company has maintained a $1.0 million loan
      receivable from Schumacher; 

    


    WHEREAS,
      following the payment in full by RAI and Schumacher of his loan to the Bank
      in February 2005, the Company became the holder of a first priority
      security interest in Schumacher's shares of the Company’s common stock to secure
      the repayment of the Company's $1,000,000 loan receivable together with
      associated accrued interest from Schumacher; 

    


    WHEREAS,
      Schumacher’s shares of the Company’s common stock constituting the collateral
      currently consists of 479,657 shares of the Company’s common stock;


    


    WHEREAS,
      the
      agreements and instruments evidencing the foregoing consist of that certain
      Junior Participation Agreement dated as of January 15, 2002 by and between
      the
      Bank, RAI, Schumacher and the Company, that certain Pledge and Security
      Agreement dated as of January 15, 2002 by and between Schumacher, the Company
      and the Bank (the “Pledge and Security Agreement”), that certain Limited
      Guaranty dated January 15, 2002 from the Company to the Bank, that certain
      Sixth
      Restated Loan Agreement dated as of January 15, 2002 by RAI in favor of the
      Bank, as assignee of BankBoston, N.A., and that certain Sixth Note Modification
      Agreement dated as of January 15, 2002 by and between RAI and the Bank, as
      assignee of BankBoston, N.A. and the various other documents referred to in
      the
      foregoing documents (together, the “Documentation”).

    


    NOW
      THEREFORE,
      the
      Company, RAI, and Schumacher agree as follows:

    


    1.
       Representations
      and Warranties of Schumacher.
      RAI and
      Schumacher hereby represent and warrant to the Company as follows:

    


    
      
         

      

      
         

        
          

        

      

      
         

      

       

    

    (a)
      Schumacher is the record and beneficial owner of, and has good and valid title
      to the Shares (as defined in Section 2, below), subject to no lien whatsoever
      except the liens created by the Pledge and Security Agreement.

    


    (b)
      Each
      of Schumacher and RAI has the power and capacity to execute, deliver and perform
      this Loan Payment Agreement. The execution, delivery and performance of this
      Loan Payment Agreement do not and will not (i) violate, or cause Schumacher
      or
      RAI to be in default, in any material respect under, any provision of any law,
      rule, regulation, order, judgment, injunction, decree or award in effect
      applicable to Schumacher or RAI, (ii) result in a breach of or constitute a
      default under any agreement to which Schumacher or RAI is a party or by which
      Schumacher’s or RAI’s property may be bound, or (iii) result in, or require, the
      creation or imposition of any lien upon or with respect to any of the properties
      now owned or hereafter acquired by Schumacher or RAI. 

    


    2 Repayment
      of Indebtedness.
      Schumacher does hereby sell, assign and transfer to the Company 249,875
      shares of the Company’s common stock (the “Shares”) owned by Schumacher and held
      by the Company as collateral under the Documentation in complete and full
      satisfaction of all amounts owed by Schumacher to the Company, including
      principal in the amount of $1,000,000 and interest accrued in Q4 2006 in the
      amount of $25,487.42 for an aggregate amount of $1,025,487.42, under and
      pursuant to the Documentation. Accompanying this Loan Repayment is a stock
      power, executed by Schumacher, relating to the Shares (the ‘Stock Power”). The
      value of the Shares has been determined by the Company and agreed to by
      Schumacher to be $4.10 per share based upon the volume weighted average
      trading price of the shares of the Company’s common stock on the NASDAQ Capital
      Market during the 60 trading day period through and including the date
      hereof. The
      Company hereby acknowledges payment in full and in complete satisfaction of
      all
      amounts and obligations owing to the Company by Schumacher under the
      Documentation.

    


    3 Release
      of Collateral.
      In
      order to effectuate the sale, assignment and transfer of the Shares to the
      Company and in connection with the repayment in full of all amounts owing to
      the
      Company by Schumacher under the Documentation as set forth in Section 2 above,
      the Company hereby releases the Shares from the security interest held by the
      Company under the Pledge and Security Agreement. The Pledge and Security
      Agreement is hereby terminated and the pledge and security interest contemplated
      thereby is hereby released. The certificates representing the Shares are being
      delivered by Schumacher and the Company to the Company’s transfer agent,
      Computershare Trust Company, Inc., along with the Stock Power, for transfer
      of
      the Shares into the name of the Company. The Company is returning herewith
      Schumacher’s remaining shares of the Company’s common stock previously held by
      the Company and subject to the Pledge and Security Agreement, and Schumacher
      acknowledges receipt of such shares. 

    


    4. Further
      Assurances.
      RAI,
      Schumacher, and the Company each will execute and deliver such further documents
      and do such further acts and things as the other may reasonably request in
      order
      to effectuate the purposes of this Loan Payment Agreement. 

    


    
      
         

      

      
         

        
          

        

      

      
         

      

    

    


    IN
      WITNESS WHEREOF, the
      Company, RAI, and Schumacher have executed this Loan Payment Agreement, under
      seal, as of this 29th day of December, 2006. 

     

    
      	 	
              PRESSURE
                BIOSCIENCES, INC.

              


              


              By:_________________________

              Title:________________________

              


              


               

              ____________________________

              Richard
                T. Schumacher 

              


               

              RESORT
                ACCOMMODATIONS INTERNATIONAL, LLC

              


              


              By:__________________________

              Title:_________________________