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Subject: Data Clarification regarding Jusko et al. 2008 EHP paper 

Dear Molini:

Please find your data request attached. Results are for untransformed lead, per 1 microgram per 

deciliter increase, broken out by the full range and by <10.

Please let me know if you have additional requests from across the lake .

Yours,

Todd

Todd Jusko, PhD

Epidemiology Branch, NIEHS

 EPA Data Request 7-19-2011.pdf 

From: Molini Patel [mailto:Patel.Molini@epamail.epa.gov] 

Sent: Monday, July 18, 2011 9:01 AM

To: Jusko, Todd (NIH/NIEHS) [F]

Subject: RE: Fwd: question regarding Jusko et al. 2008 EHP paper

Hi Todd,

The slope estimates for the entire range of blood Pb levels and for blood Pb levels < 10 would be

informative. It would also help to have information on the statistical model you use: linear, nonlinear, 

other, with log10 or log e transformed blood Pb levels, etc. Thanks again! Molini

Molini M. Patel, PhD, MPH

Epidemiologist

U.S. Environmental Protection Agency

National Center for Environmental Assessment

Mail drop: B243-01

Research Triangle Park, NC 27711

Telephone: (919) 541-1492

Email: patel.molini@epa.gov

From: "Jusko, Todd (NIH/NIEHS) [F]" <Todd.Jusko@nih.gov> 

To: Molini Patel/RTP/USEPA/US@EPA 

Date: 07/15/2011 02:23 PM 

Subject: RE: Fwd: question regarding Jusko et al. 2008 EHP paper 

Molini, I can run these. 

 

Do you want the slopes for the entire range of blood lead, <10, etc...? 

 

Todd 
From: Molini Patel [mailto:Patel.Molini@epamail.epa.gov]

Sent: Thursday, July 14, 2011 3:08 PM

To: Jusko, Todd (NIH/NIEHS) [F]

Subject: Re: Fwd: question regarding Jusko et al. 2008 EHP paper

 

Thanks for your quick reply. I thought you may have performed separate analyses for the three blood Pb 

intervals. On a related note, most of the results in that paper are presented as differences in IQ between 

different blood Pb groups. If you have slope estimates for concurrent, infancy average, lifetime average, 

or peak blood Pb levels analyzed as a continuous variable and can share them with us, we would

appreciate it. Thanks again for your help.

Best regards,

Molini

Molini M. Patel, PhD, MPH

Epidemiologist

U.S. Environmental Protection Agency

National Center for Environmental Assessment

Mail drop: B243-01

Research Triangle Park, NC 27711

Telephone: (919) 541-1492

Email: patel.molini@epa.gov

From: "Jusko, Todd (NIH/NIEHS) [F]" <Todd.Jusko@nih.gov> 

To: Molini Patel/RTP/USEPA/US@EPA 

Cc: Rick Canfield <rlc5@cornell.edu> 

Date: 07/13/2011 06:48 PM 

Subject: Fwd: question regarding Jusko et al. 2008 EHP paper 

Dear Dr. Patel:

We did not use a formal model to generate those estimates. They are based on the average decline in 

IQ per blood lead interval in the semiparametric model. Thinking about this some more, I'm not sure 

how one would go about estimating the variance for such figures (maybe some sort of spline with knots 

at those points...).

If you have any other related questions about our data (or that model), let me know. There may be 

more obvious parametric ways of getting the information you need that I could help with .

Todd Jusko, PhD

Epidemiology Branch, NIEHS

From: Molini Patel [mailto:Patel.Molini@epamail.epa.gov]

Sent: Wednesday, July 13, 2011 11:35 AM

To: Richard Canfield

Subject: question regarding Jusko et al. 2008 EHP paper

Dear Dr. Canfield,

We currently are developing the Integrated Science Assessment for Lead and 

hope you are able to provide additional information regarding your Jusko et 

al. 2008 paper in Environmental Health Perspectives (Jusko TA, Henderson CR 

Jr., Lanphear BP, Cory-Slechta DA, Parsons PJ, et al. 2007 Blood Lead 
Concentrations < 10 μg/dL and Child Intelligence at 6 Years of Age. Environ

Health Perspect 116(2): doi:10.1289/ehp.10424 ).

In the nonlinear analysis of peak blood Pb levels and IQ, the slopes were 

reported to be steeper at lower blood Pb levels. For the ranges of 2.1-10, 

10-20, and 20-30 ug/dL, slopes were -1.2, -0.32, and -0.15 per a 1 ug/dL 

increase in peak blood Pb level, respectively. We are interested in the 95% 

confidence intervals for these three point estimates and hope you are able to 

provide them to us. Thank you for your assistance.

Molini M. Patel, PhD, MPH

Epidemiologist

U.S. Environmental Protection Agency

National Center for Environmental Assessment

Mail drop: B243-01

Research Triangle Park, NC 27711

Telephone: (919) 541-1492

Email: patel.molini@epa.gov
EPA Data Request 7/15/2011: Child blood lead measures and adjusted* IQ at age 6 years in the Rochester Lead Study. 

 Full-Scale IQ Performance IQ 

Blood Lead Measure N β† 95% CI p-value β 95% CI p-value β 

Lifetime Average 

Full range of Lifetime Average 174 -0.41 -0.92, 0.09 0.11 -0.61 -1.12, -0.10 0.02 -0.15 Lifetime Average <10 134 -1.72 -2.93, -0.50 0.006 -1.68 -2.89, -0.47 0.007 -1.53 

Concurrent 

Full range of Concurrent 174 -0.66 -1.26, -0.06 0.03 -0.93 -1.53, -0.33 0.003 -0.31 Concurrent <10 160 -0.84 -1.84, 0.16 0.10 -1.26 -2.26, -0.26 0.01 -0.38 

Infancy Average 

Full range of Infancy Average 174 -0.16 -0.67, 0.34 0.52 -0.46 -0.97, 0.05 0.08 0.16 Infancy Average <10 141 -0.86 -1.95, 0.23 0.12 -1.16 -2.25, -0.06 0.04 -0.45 

Peak 

Full range of Peak 174 -0.19 -0.46, 0.07 0.16 -0.32 -0.58, -0.05 0.02 -0.03 Peak <10 96 -1.66 -3.10, -0.23 0.02 -1.86 -3.31, -0.41 0.01 -1.21 

*Adjusted for child’s sex, birth weight, and transferrin saturation; mother’s race, IQ, and education level; HOME-SF total scomaternal prenatal smoking †Change in IQ per 1 μg/dl increase in blood lead concentration