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### Dear Molini:

Please find your data request attached. Results are for untransformed lead, per 1 microgram per deciliter increase, broken out by the full range and by <10.

Please let me know if you have additional requests from across the lake .

Yours,
Todd

Todd Jusko, PhD Epidemiology Branch, NIEHS

EPA Data Request 7-19-2011.pdf

From: Molini Patel [mailto:Patel.Molini@epamail.epa.gov] Sent: Monday, July 18, 2011 9:01 AM
To: Jusko, Todd (NIH / NIEHS) [F] Subject: RE: Fwd: question regarding Jusko et al. 2008 EHP paper

Hi Todd, The slope estimates for the entire range of blood P b levels and for blood Pb levels < 10 would be informative. It would also help to have informatio n on the statistical model you use: linear, nonline ar, other, with log 10 or log e transformed blood Pb levels, etc. Than ks again! Molini

Molini M. Patel, PhD, MPH Epidemiologist U.S. Environmental Protection Agency
National Center for Environmental Assessment Mail drop: B243-01 Research Triangle Park, NC 27711 Telephone: (919) 541-1492 Email: patel.molini@epa.gov



### From: "Jusko, Todd (NIH/NIEHS) [F]" <Todd.Jusko@nih.gov> To: Molini Patel/RTP/USEPA/US@EPA Date: 07/15/2011 02:23 PM Subject: RE: Fwd: question regarding Jusko et al. 2008 EHP paper

Molini, I can run these.

Do you want the slopes for the entire range of blood lead, <10, etc...?

ToddFrom : Molini Patel [ mailto : Patel

. Molini @ epamail

. epa

. gov ]

Sent: Thursday , July 14, 2011 3:08 PM
To: Jusko, Todd (NIH / NIEHS) [F] Subject: Re: Fwd: question regarding Jusko et al. 2008 EHP paper

Thanks for your quick reply. I thought you may hav e performed separate analyses for the three blood P b intervals. On a related note, most of the results in that paper are presented as differences in IQ be tween different blood Pb groups. If you have slope estim ates for concurrent, infancy average, lifetime aver age, or peak blood Pb levels analyzed as a continuous va riable and can share them with us, we would appreciate it. Thanks again for your help. Best regards,

Molini

Molini M. Patel, PhD, MPH Epidemiologist U.S. Environmental Protection Agency
National Center for Environmental Assessment Mail drop: B243-01 Research Triangle Park, NC 27711 Telephone: (919) 541-1492 Email: patel.molini@epa.gov



### From: "Jusko, Todd (NIH/NIEHS) [F]" <Todd.Jusko@nih.gov> To: Molini Patel/RTP/USEPA/US@EPA Cc: Rick Canfield <rlc5@cornell.edu> Date: 07/13/2011 06:48 PM Subject: Fwd: question regarding Jusko et al. 2008 EHP paper

Dear Dr. Patel:

We did not use a formal model to generate those estimates. They are based on the average decline in IQ per blood lead interval in the semiparametric model. Thinking about this some more, I'm not sure how one would go about estimating the variance for such figures (maybe some sort of spline with knots at those points...).

If you have any other related questions about our data (or that model), let me know. There may be more obvious parametric ways of getting the information you need that I could help with .

Todd Jusko, PhD Epidemiology Branch, NIEHS

From: Molini Patel [mailto : Patel

. Molini @ epamail

. epa

. gov ] Sent: Wednesday, July 13, 2011 11:35 AM To: Richard Canfield Subject: question regarding Jusko et al. 2008 EHP p aper

Dear Dr. Canfield, We currently are developing the Integrated Science Assessment for Lead and hope you are able to provide additional information regarding your Jusko et al. 2008 paper in Environmental Health Perspectives (Jusko TA, Henderson CR Jr., Lanphear BP, Cory-Slechta DA, Parsons PJ, et a l. 2007 Blood LeadConcentrations < 10 μ g / dL and Child Intelligence at 6 Years of Age

. Environ

Health Perspect 116(2): doi:10.1289/ehp.10424 ).

In the nonlinear analysis of peak blood Pb levels a nd IQ, the slopes were reported to be steeper at lower blood Pb levels. F or the ranges of 2.1-10, 10-20, and 20-30 ug/dL, slopes were -1.2, -0.32, an d -0.15 per a 1 ug/dL increase in peak blood Pb level, respectively. We are interested in the 95% confidence intervals for these three point estimate s and hope you are able to provide them to us. Thank you for your assistance.

Molini M. Patel, PhD, MPH Epidemiologist U.S. Environmental Protection Agency National Center for Environmental Assessment Mail drop: B243-01 Research Triangle Park, NC 27711 Telephone: (919) 541-1492 Email: patel.molini@epa.govEPA Data Request 7/15/2011: Child blood lead measures and adjusted* IQat age 6 years in the Rochester Lead Study.Full-Scale IQ Performance IQ Verbal IQBlood Lead Measure Nβ† 95% CI p-valueβ95% CI p-valueβ95% CI p-valueLifetime AverageFull range of Lifetime Average 174 -0.41 -0.92, 0.09 0.11-0.61 -1.12, -0.10 0.02 -0.15 -0.73, 0.43 0.60Lifetime Average <10 134 -1.72 -2.93, -0.50 0.006 -1.68 -2.89, -0.47 0.007 -1.53 -2.91, -0.16 0.03ConcurrentFull range of Concurrent 174 -0.66 -1.26, -0.06 0.03-0.93 -1.53, -0.33 0.003 -0.31 -1.01, 0.38 0.38Concurrent <10 160 -0.84 -1.84, 0.16 0.10 -1.26 -2.26, -0.26 0.01 -0.38 -1.53, 0.77 0.51Infancy AverageFull range of Infancy Average 174 -0.16 -0.67, 0.34 0.52-0.46 -0.97, 0.05 0.08 0.16 -0.42, 0.73 0.59Infancy Average <10 141 -0.86 -1.95, 0.23 0.12 -1.16 -2.25, -0.06 0.04 -0.45 -1.67, 0.77 0.47PeakFull range of Peak 174 -0.19 -0.46, 0.07 0.16 -0.32 -0.58, -0.05 0.02 -0.03 -0.33, 0.28 0.86Peak <10 96 -1.66 -3.10, -0.23 0.02 -1.86 -3.31, -0.41 0.01 -1.21 -2.87, 0.44 0.15*Adjusted for child’s sex, birth weight, and transferrin saturation; mother’s race, IQ, and education level; HOME-SF total score, family income, andmaternal prenatal smoking†Change in IQ per 1 μg/dl increase in blood lead concentration