-- 

I . ...,, 

c 

u -. . ) Case #: P-00-0007 1 

i;DCN: a 0021-00 78-00R.,

- . SAT Date: 10/19/99 SAT Chair: B. Jones - . 3 . . . 

I Submitter: . 0 Kelco Biopdymers, unit of Monsanto f 

-

... 

ID- 6-dkoxy-L-mannose and D-glucose, acetate,calcium magnesium 

$ 

-:Po . 

I

j 

; .. 

.. 

.. <, 

i

i 

i f . 

i CAS RN: !TradeNark . 

i

I

i

1

i 

I

I

I Na' 

.i

! 0 

I K+ 

Mg++ 

0 Ca++ 

: 

lolecular Formula: 

j

i 

I 

i

I! IS�: 

, 

7 

Case Role 

I I ' I I I 

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STRUCTURE ACTIVITY TEAM REPORT 

CASE NUMBER : POO-0007 

RELATED CASES: 

CONCLUSIQNS/DISCUSSIONS 

TYPE OF CONCERN: HEALTH ECOTOX 

LEVEL OF CONCERN: 1-2, 1 

KEYWORDS: 

LUNG 

SUMMARY OF ASSESSMENT 

FATE: Solid 

S = 40 g/L(M); VP @ 25C (mm) c 1.OE-6(E); H e l.OOE-d(E)

POTW removal (%) = 90 via sorption

Time for complete ultimate aerobic biodeg 2 mo 

PBT Potential: P2BlT1 

Sorption to soils/sediments = v.strong ­ *CEB FATE: Migration to ground water = negl 

HEALTH: Absorption is nil all routes based on physical/chemlcal

properties. There is concern for lung effects if respirable

particles are inhaled based on the high molecular weight of 

5,000,000. It is not clear if the PMN material will swell. 

*CEB HEALTH: Low moderate concern (InhalationJofrespirable

particles). XB: Testing desired. 

TOXICITY DATA: acute oral study in rats - no deaths or signs of 

toxicity at 5 g/kg 

not an eye irritant 

acute inhalation study in rats - no deaths at 4.9 mg/l,

intermittent nose-rubbing during exposure, 2 of 10 had mottled 

lungs, 1 had mottlea lungs with areas of consolidation, 1 had 

mottled kidney; 2 animals in unexposed control group also had 

mottled lungs 

ECOTOX: Predicted (P) and meksured (M) toxicity values in mg/L

(pprn) are: 

fish 96-h LC50 5 100.0 P 

daphnid 48-h LC50 > 100.0 P 

green algal 96-h EC50 > 100.0 P 

fish chronic yalue > 10.0 P b 

daphnid ChV ;> 10.0 P 

algal ChV > 10.0 P 

Predictions are based on SARs for polyanionic polymers; SAX 

chemical class = polymer-anionic-COOH-sugar; MW5 0'00000 with C4 

<1000; pH7; effective concentrations based on 100% active 

2 

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ingredients and nominal concentrations; hardness <180.0 mg/L as 

CaC03; and TOC (2.0 mg/L;

low concern 

assessment factor = 10.0 

concern concentration = 1.0 

*CEB ECOTOX: NO releases to water; XB: NO testing. c 

Becky Jones 260-3461 

, 

, 

! 

3 

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4 

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' ­

.. 

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~CSABSAT REPORT 

=MN: P-00-0007 CAS RN: 

2hemical Name: 

0-Glucuronic acid, polymer with 6-deoxy-L-mannoseand-0-glucose, 

acetate,calcium magnesium potassium sodium salt 

CBI? (Y/N): 

125005-8 

I

Analogs: 

Production Volume. 

Na+ 

K+ 

Mg++ 

%a++ 

0.00Wt%-=1000 00 

VP: < 0 00000 

Solid Log p: 

~­

0 

.- I i. 

C22H39KNa017 Eq Wt: 

6;Cod,oc7,a 

vr"I; 

Formula: 

Mol Weight: 

MP: 

H20 Sol (g/L): 

Endpoint (mg/L) 

Fish 96-h 

Daphnid 48-h 

Algal 96-h 

Fish ChV 

]Algal ChV 

I 

IBCF 

I 

Est. Value 

am 

> (00 

>rod 

7P 

)p f0 

BP: I 

4qPhysical State: 

Meas. Value Comments 

-

CHEMICAL CLASS: 

ECOTOXCONCERN H M 

DATE [o /I q/?? 

NCERN CONC~NTRATION /a 6 

7 

I 

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