`U.S. SECURITIES AND EXCHANGE COMMISSION
                                                  WASHINGTON, D.C. 20549

                                                         FORM 10-K

[X]  ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2007

                                                            OR

[  ]  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from ____ to ____

                                               Commission file no. 33-94288

                                                THE FIRST BANCSHARES, INC.
                                    --------------------------------------------------
                                  (Exact name of registrant as specified in its charter)

                 Mississippi                                                        64-0862173
-------------------------------------------------              ----------------------------------------------------------
         (State or Other Jurisdiction of                              (I.R.S. Employer Identification Number)
         Incorporation or Organization)

           6480 U.S. Hwy. 98 West
           Hattiesburg, Mississippi                                                     39402
-------------------------------------------------             -----------------------------------------------------------
     (Address of principal executive offices)                                        (Zip Code)

Issuer's telephone number:                   (601) 268-8998
                                ----------------------------------------------------

Securities registered under Section 12(b) of the Exchange Act:

                                                                        Name of Each Exchange on
             Title of EacClass                                              Which Registered
             -----------------                                          ------------------------

         Common Stock, $1.00 par value                                   NASDAQ Stock Market, LLC
--------------------------------------------------             ----------------------------------------------------------

Securities registered pursuant to Section 12(g) of the Act:  None`

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`Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in rule 405 of the Securities Act.

Yes                        No      X
   -----------               ------------

         Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d)
of the Act.

Yes                      No        X
   -----------               ------------

Note - Checking the box above will not relieve any registrant required to file reports pursuant to Section 13 or 15(d) of
the Exchange Act from their obligations under those Sections.

         Indicate by check mark whether  the registrant  (1) has filed all reports required to be filed by Section 13 or
15(d) of the Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was
required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.

Yes     X                 No
   -----------               ------------

         Indicate by check mark  if  disclosure of delinquent filers in response to Item 405 of Regulation S-K is not
contained herein, and will not be contained, to the best of the registrant's knowledge, in definitive proxy or
information statements incorporated by reference in Part III of this Form 10-K or any amendment to this
Form 10-K   [ X ]

         Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange
Act).      Yes [  ]      No  [ X ]


         Indicate by check mark whether the registrant is a large accelerated file, an accelerated filer,  a
non-accelerated filer, or a smaller reporting company.  See the definitions of "large accelerated filer," "accelerated
filer," and "smaller reporting company" in Rule 12b-2 of the Exchange Act  (Check one):

Large accelerated filer       Accelerated filer      Non-accelerated filer      Smaller reporting company   X
                        ----                   ----                        ----                           -----


         Based on the price at which the registrant's Common Stock was last sold at June 29, 2007, at that date, the
aggregate market value of  the registrant's  Common Stock held by non-affiliates of the registrant (assuming solely for
the purposes of this calculation that all directors and executive officers of the registrant are "affiliates") was
$55,606,023.

         State the number of shares outstanding of each of the registrant's classes of common stock, as of the latest
practicable date.  2,989,401 on March 25, 2008.

                                            DOCUMENTS INCORPORATED BY REFERENCE

         Portions of the following documents are incorporated by reference to Parts II and III of the Form 10-K report:
Proxy Statement dated April 17, 2008, and the Annual Report to the Stockholders for the year ended December 31, 2007.`

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`THE FIRST BANCSHARES, INC.
                                                         FORM 10-K
                                                     TABLE OF CONTENTS
                                                                                                                 Page

                                                               PART I

ITEM 1.        BUSINESS........................................................................................1
ITEM 1A.       RISK FACTORS.................................................................................. 10
ITEM 1B.       UNRESOLVED STAFF COMMENTS......................................................................14
ITEM 2.        PROPERTIES.....................................................................................14
ITEM 3.        LEGAL PROCEEDINGS..............................................................................14
ITEM 4.        SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS............................................14

                                                         PART II

ITEM 5.        MARKET FOR REGISTRANT'S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER
               PURCHASES OF EQUITY SECURITIES.................................................................14
ITEM 6.        SELECTED FINANCIAL DATA........................................................................14
ITEM 7.        MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS........................15
ITEM 7A.       QUANTITATIVE AND QUALITATIVE DISCLOSURES.......................................................15
ITEM 8.        FINANCIAL STATEMENTS...........................................................................15
ITEM 9.        CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE...........15
ITEM 9A(T).    CONTROLS AND PROCEDURES........................................................................15
ITEM 9B.       OTHER INFORMATION..............................................................................16

                                                         PART III

ITEM 10.       DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT.............................................16
ITEM 11.       EXECUTIVE COMPENSATION.........................................................................16
ITEM 12.       SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED
               STOCKHOLDER MATTERS............................................................................17
ITEM 13.       CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS.................................................17
ITEM 14.       PRINCIPAL ACCOUNTANT FEES AND SERVICES.........................................................17

                                                              PART IV

ITEM 15.       EXHIBITS AND FINANCIAL STATEMENT SCHEDULES.....................................................17`

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PART I

This Report contains statements which
constitute forward-looking statements within the meaning of Section 27A of the Securities
Act of 1933 and the Securities Exchange Act of 1934. These statements appear in a number
of places in this Report and include all statements regarding the intent, belief or
current expectations of the Company, its directors or its officers with respect to, among
other things: (i) the Companys financing plans; (ii) trends affecting the
Companys financial condition or results of operations; (iii) the Companys
growth strategy and operating strategy; and (iv) the declaration and payment of dividends.
Investors are cautioned that any such forward-looking statements are not guarantees of
future performance and involve risks and uncertainties, and that actual results may differ
materially from those projected in the forward-looking statements as a result of various
factors discussed herein and those factors discussed in detail in the Companys
filings with the Securities and Exchange Commission.

ITEM 1.   BUSINESS.

BUSINESS OF THE COMPANY

General

The First Bancshares, Inc. (the
Company) was incorporated on June 23, 1995 to serve as a holding company for
The First, A National Banking Association (The First) located in Hattiesburg,
Mississippi. The First began operations on August 5, 1996 from its main office in the Oak
Grove community, which was on the outskirts of Hattiesburg but now is included in the city
of Hattiesburg. In addition to the main office in Hattiesburg and the branch in Laurel,
The First also operates two other branches in Hattiesburg, one in Purvis, one in Picayune,
one in Pascagoula, one in Bay St. Louis, one in Wiggins, and one in Gulfport, Mississippi.
The Company and its subsidiary bank engage in a general commercial and retail banking
business characterized by personalized service and local decision-making, emphasizing the
banking needs of small to medium-sized businesses, professional concerns and individuals.
The First is a wholly-owned subsidiary bank of the Company.

Location and Service Area

The First serves the cities of
Hattiesburg, Laurel, Purvis, Picayune, Pascagoula, Bay St. Louis, Wiggins, Gulfport and
the surrounding areas of Lamar, Forrest, Jones, Pearl River ,Jackson, Hancock, Stone and
Harrison Counties, Mississippi. The First has a main office located in the city of
Hattiesburg, Mississippi, in Lamar County. The First has a branch office located on
Highway 589 in the city of Purvis, Mississippi, also in Lamar County, a third office
located at the intersection of Lincoln Road and South 28th Avenue in Hattiesburg, a fourth
location at 3318 Hardy Street in Hattiesburg, a fifth location at Hwy 15 North in Laurel,
a sixth location at Hwy 43 South in Picayune, a seventh location at Jackson Avenue in
Pascagoula, an eighth location at Hwy 90 in Bay St. Louis, a ninth location at Border Ave.
in Wiggins and a tenth location at Hwy 49 and ONeal Rd in Gulfport, Mississippi.

The main office primarily serves the
area in and around the northern portion of Lamar County. The Purvis office primarily
serves the area in and around Purvis, Mississippi, which is in the east central part of
Lamar County and is the county seat. Lamar County is located in the southeastern section
of Mississippi. Hattiesburg, one of the largest cities in Mississippi, is located in
Forrest and Lamar Counties. The Laurel office serves the city of Laurel and the
surrounding area of Jones County, Mississippi. The Picayune office primarily serves the
area in and around Picayune, Mississippi, including areas of north Hancock County and
Pearl River, LA and Slidell, LA. Picayune is located in the southern part of Pearl River
County. Pearl River County is located in the southern section of Mississippi. The
Pascagoula office primarily serves the area in and around Pascagoula, Mississippi,
including areas of Jackson County. Hattiesburg can be reached via U.S. Highways 98 and 49
and Interstate 59. Major employers located in the Lamar and Forrest County areas include
Forrest General Hospital, the University of Southern Mississippi, Wesley Medical Center,
Camp Shelby, the Hattiesburg Public Schools, the Hattiesburg Clinic, the City of
Hattiesburg, and Marshall Durbin Poultry. The principal components of the economy of the
Lamar and Forrest County areas include service industries, wholesale and retail trade,
manufacturing, and transportation and public utilities. The Laurel branch is located at
1945 Highway 15 North, Laurel, MS, with the majority of its retail business coming from
the local area and the remaining business coming from other areas of Jones County, as well
as portions of Jasper County, Wayne County, Smith County, and Covington County. Major
employers in the Jones County area include Howard Industries, Sanderson Farms, Inc., and
South Central Regional Medical Center. Major employers in the Pearl River County area include
Stennis Space Center, Chevron, Texaco, Arizona Chemical, American Crescent Elevator Co.,
City of Picayune, Crosby Memorial Hospital and the public schools. The principal components
of the economy of the Pearl River County area include timer, service industries, wholesale and
retail trade, manufacturing, and transportation and public utilities.  Major employers in the
Jackson County area include Northrop Grumman, Singing River Hospital, and Shell Oil Company.
The Bay St. Louis office serves the City of Bay St. Louis and the surrounding area of Hancock
County, Mississippi. Bay St. Louis can be reached via U.S. Highway 90. Major employers in the
Hancock area include the City of Bay St. Louis, Hancock County, and Stennis Space Center. The
Wiggins office serves the City of Wiggins and the surrounding area of Stone County, Mississippi.
Stone County is south of Forrest County and north of Harrison County.  Wiggins can be reached
via U. S. Highway 49. The Gulfport office serves the City of Gulfport and the surrounding area
of Harrison County, Mississippi. Gulfport can be reached via U.S. Highway 49. Major employers in
the Harrison County area include Keesler Air Force Base and a vast array of casinos.

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Banking Services

The Company strives to provide its
customers with the breadth of products and services comparable to those offered by large
regional banks, while maintaining the quick response and personal service of a locally
owned and managed bank. In addition to offering a full range of deposit services and
commercial and personal loans, The First offers products such as mortgage loan
originations. The following is a description of the products and services offered or
planned to be offered by the Bank.

`        Deposit Services.  The Bank offers a full range of deposit services that are typically available in most banks
         and savings and loan associations, including checking accounts, NOW accounts, savings accounts, and other time
         deposits of various types, ranging from daily money market accounts to longer-term certificates of deposit.  The
         transaction accounts and time certificates are tailored to the Bank's principal market area at rates competitive
         to those offered by other banks in the area.  In addition, the Bank offers certain retirement account services,
         such as Individual Retirement Accounts (IRAs).  All deposit accounts are insured by the Federal Deposit Insurance
         Corporation (the "FDIC") up to the maximum amount allowed by law.  The Bank solicits these accounts from
         individuals, businesses, associations and organizations, and governmental authorities.

        Loan Products.  The Bank offers a full range of commercial and personal loans.  Commercial loans include both
         secured and unsecured loans for working capital (including loans secured by inventory and accounts receivable),
         business expansion (including acquisition of real estate and improvements), and purchase of equipment and
         machinery.  Consumer loans include equity lines of credit and secured and unsecured loans for financing
         automobiles, home improvements, education, and personal investments.  The Bank also makes real estate
         construction and acquisition loans.  The Bank's lending activities are subject to a variety of lending limits
         imposed by federal law.  While differing limits apply in certain circumstances based on the type of loan or the
         nature of the borrower (including the borrower's relationship to the bank), in general the Bank is subject to a
         loans-to-one-borrower limit of an amount equal to 15% of the Bank's unimpaired capital and surplus.  The Bank may
         not make any loans to any director,  executive officer, or 10% shareholder unless the loan is approved by the
         Board of Directors of the Bank and is made on terms not more favorable to such a person than would be available
         to a person not affiliated with the Bank.

        Mortgage Loan Divisions.  The Bank has mortgage loan divisions which originate loans to purchase existing or
         construct new homes and to refinance existing mortgages.

        Other Services.  Other bank services include on-line Internet banking services, voice response telephone inquiry
         service, commercial sweep accounts, cash management services, safe deposit boxes, travelers checks, direct
         deposit of payroll and social security checks, and automatic drafts for various accounts.  The Bank is associated
         with the Money Belt, Gulfnet, and Plus networks of automated teller machines that may be used by the Bank's
         customers throughout Mississippi and other regions.  The Banks also offer VISA and MasterCard credit card
         services through a correspondent bank.`

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Competition

The Bank generally competes with
other financial institutions through the selection of banking products and services
offered, the pricing of services, the level of service provided, the convenience and
availability of services, and the degree of expertise and the personal manner in which
services are offered. Mississippi law permits statewide branching by banks and savings
institutions, and many financial institutions in the state have branch networks.
Consequently, commercial banking in Mississippi is highly competitive. Many large banking
organizations currently operate in the Companys market area, several of which are
controlled by out-of-state ownership. In addition, competition between commercial banks
and thrift institutions (savings institutions and credit unions) has been intensified
significantly by the elimination of many previous distinctions between the various types
of financial institutions and the expanded powers and increased activity of thrift
institutions in areas of banking which previously had been the sole domain of commercial
banks. Federal legislation, together with other regulatory changes by the primary
regulators of the various financial institutions, has resulted in the almost total
elimination of practical distinctions between a commercial bank and a thrift institution.
Consequently, competition among financial institutions of all types is largely unlimited
with respect to legal ability and authority to provide most financial services.

The Company faces increased
competition from both federally-chartered and state-chartered financial and thrift
institutions, as well as credit unions, consumer finance companies, insurance companies,
and other institutions in the Companys market area. Some of these competitors are
not subject to the same degree of regulation and restriction imposed upon the Company.
Many of these competitors also have broader geographic markets and substantially greater
resources and lending limits than the Company and offer certain services such as trust
banking that the Company does not currently provide. In addition, many of these
competitors have numerous branch offices located throughout the extended market areas of
the Company that may provide these competitors with an advantage in geographic convenience
that the Company does not have at present.

Currently there are numerous other
commercial banks, savings institutions, and credit unions operating in The Firsts
primary service area.

Employees

As of March 25, 2008 the Company had
171 full-time employees and 13 part-time employees.

SUPERVISION AND
REGULATION

The Company and its bank are subject
to state and federal banking laws and regulations which impose specific requirements or
restrictions on and provide for general regulatory oversight with respect to virtually all
aspects of operations. These laws and regulations are generally intended to protect
depositors, not shareholders. To the extent that the following summary describes statutory
or regulatory provisions, it is qualified in its entirety by reference to the particular
statutory and regulatory provisions. Any change in applicable laws or regulations may have
a material effect on the business and prospects of the Company. Beginning with the
enactment of the Financial Institutions Reform, Recovery and Enforcement Act of 1989
(FIRREA) and following with Federal Deposit Insurance Corporation Improvement
Act of 1991 (FDICIA), numerous additional regulatory requirements have been
placed on the banking industry in the past several years, and additional changes have been
proposed. The operations of the Company and the Bank may be affected by legislative
changes and the policies of various regulatory authorities. The Company is unable to
predict the nature or the extent of the effect on its business and earnings that fiscal or
monetary policies, economic control, or new federal or state legislation may have in the
future.

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The Company

Because it owns the outstanding
capital stock of the Bank, the Company is a bank holding company within the meaning of the
Federal Bank Holding Company Act of 1956 (the BHCA).

The BHCA.    Under the BHCA, the Company
is subject to periodic examination by the Federal Reserve and is required to file periodic
reports of its operations and such additional information as the Federal Reserve may
require. The Companys and the Banks activities are limited to banking,
managing or controlling banks, furnishing services to or performing services for its
subsidiaries, and engaging in other activities that the Federal Reserve determines to be
so closely related to banking or managing or controlling banks as to be a proper incident
thereto.

Investments, Control, and Activities.   
With certain limited exceptions, the BHCA requires every bank holding company to obtain
the prior approval of the Federal Reserve before (i) acquiring substantially all the
assets of any bank, (ii) acquiring direct or indirect ownership or control of any voting
shares of any bank if after such acquisition it would own or control more than 5% of the
voting shares of such bank (unless it already owns or controls the majority of such
shares), or (iii) merging or consolidating with another bank holding company.

In addition, and subject to certain
exceptions, the BHCA and the Change in Bank Control Act, together with regulations
thereunder, require Federal Reserve approval (or, depending on the circumstances, no
notice of disapproval) prior to any person or company acquiring control of a
bank holding company, such as the Company. Control is conclusively presumed to exist if an
individual or company acquires 25% or more of any class of voting securities of the bank
holding company. Control is rebuttably presumed to exist if a person acquires 10% or more
but less than 25% of any class of voting securities and either the Company has registered
securities under Section 12 of the Exchange Act (which the Company has done) or no other
person owns a greater percentage of that class of voting securities immediately after the
transaction. The regulations provide a procedure for challenge of the rebuttable control
presumption.

Under the BHCA, a bank holding
company is generally prohibited from engaging in, or acquiring direct or indirect control
of more than 5% of the voting shares of any company engaged in nonbanking activities,
unless the Federal Reserve Board, by order or regulation, has found those activities to be
so closely related to banking or managing or controlling banks as to be a proper incident
thereto. Some of the activities that the Federal Reserve Board has determined by
regulation to be proper incidents to the business of a bank holding company include making
or servicing loans and certain types of leases, engaging in certain insurance and discount
brokerage activities, performing certain data processing services, acting in certain
circumstances as a fiduciary or investment or financial adviser, owning savings
associations, and making investments in certain corporations or projects designed
primarily to promote community welfare.

The Federal Reserve Board has imposed
certain capital requirements on the Company under the BHCA, including a minimum leverage
ratio and a minimum ratio of qualifying capital to risk-weighted assets. These
requirements are described below under Capital Regulations. Subject to its
capital requirements and certain other restrictions, the Company may borrow money to make
a capital contribution to the Banks, and such loans may be repaid from dividends paid from
the Bank to the Company (although the ability of the Bank to pay dividends is subject to
regulatory restrictions as described below in The Bank  Dividends). The
Company is also able to raise capital for contribution to the Bank by issuing securities
without having to receive regulatory approval, subject to compliance with federal and
state securities laws.

Source of Strength; Cross-Guarantee.   
In accordance with Federal Reserve Board policy, the Company is expected to act as a
source of financial strength to the Bank and to commit resources to support the Bank in
circumstances in which the Company might not otherwise do so. Under the BHCA, the Federal
Reserve Board may require a bank holding company to terminate any activity or relinquish
control of a nonbank subsidiary (other than a nonbank subsidiary of a bank) upon the
Federal Reserve Boards determination that such activity or control constitutes a
serious risk to the financial soundness or stability of any subsidiary depository
institution of the bank holding company. Further, federal bank regulatory authorities have
additional discretion to require a bank holding company to divest itself of any bank or
nonbank subsidiary if the agency determines that divestiture may aid the depository
institutions financial condition.

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The Bank

The Bank operates as a national
banking association incorporated under the laws of the United States and subject to
examination by the Office of Comptroller of the Currency (OCC). Deposits in
the Bank are insured by the FDIC up to a maximum amount (generally $100,000 per depositor,
subject to aggregation rules). The OCC and the FDIC regulate or monitor virtually all
areas of the Banks operations, including security devices and procedures, adequacy
of capitalization and loan loss reserves, loans, investments, borrowings, deposits,
mergers, issuances of securities, payment of dividends, interest rates payable on
deposits, interest rates or fees chargeable on loans, establishment of branches, corporate
reorganizations, maintenance of books and records, and adequacy of staff training to carry
on safe lending and deposit gathering practices. The OCC requires the Bank to maintain
certain capital ratios and imposes limitations on the Banks aggregate investment in
real estate, bank premises, and furniture and fixtures. The Bank is required by the OCC to
prepare quarterly reports on their financial condition and to conduct an annual audit of
their financial affairs in compliance with minimum standards and procedures prescribed by
the OCC.

Under FDICIA, all insured
institutions must undergo regular on-site examinations by their appropriate banking
agency. The cost of examinations of insured depository institutions and any affiliates may
be assessed by the appropriate agency against each institution or affiliate as it deems
necessary or appropriate. Insured institutions are required to submit annual reports to
the FDIC and the appropriate agency (and state supervisor when applicable). FDICIA also
directs the FDIC to develop with other appropriate agencies a method for insured
depository institutions to provide supplemental disclosure of the estimated fair market
value of assets and liabilities, to the extent feasible and practicable, in any balance
sheet, financial statement, report of condition, or any other report of any insured
depository institution. FDICIA also requires the federal banking regulatory agencies to
prescribe, by regulation, standards for all insured depository institutions and depository
institution holding companies relating, among other things, to: (i) internal controls,
information systems, and audit systems; (ii) loan documentation; (iii) credit
underwriting; (iv) interest rate risk exposure; and (v) asset quality.

National banks and their holding
companies which have been chartered or registered or undergone a change in control within
the past two years or which have been deemed by the OCC or the Federal Reserve Board,
respectively, to be troubled institutions must give the OCC or the Federal Reserve Board,
respectively, thirty days prior notice of the appointment of any senior executive officer
or director. Within the thirty day period, the OCC or the Federal Reserve Board, as the
case may be, may approve or disapprove any such appointment.

Deposit Insurance.    The FDIC
establishes rates for the payment of premiums by federally insured banks and thrifts for
deposit insurance. A separate Bank Insurance Fund (BIF) and Savings
Association Insurance Fund (SAIF) are maintained for commercial banks and
thrifts, respectively, with insurance premiums from the industry used to offset losses
from insurance payouts when banks and thrifts fail. Since 1993, insured depository
institutions like the Bank have paid for deposit insurance under a risk-based premium
system.

Transactions With Affiliates and
Insiders.    The Bank is subject to Section 23A of the Federal Reserve Act, which places
limits on the amount of loans to, and certain other transactions with, affiliates, as well
as on the amount of advances to third parties collateralized by the securities or
obligations of affiliates. The aggregate of all covered transactions is limited in amount,
as to any one affiliate, to 10% of the Banks capital and surplus and, as to all
affiliates combined, to 20% of the Banks capital and surplus. Furthermore, within
the foregoing limitations as to amount, each covered transaction must meet specified
collateral requirements.

The Bank is also subject to Section
23B of the Federal Reserve Act, which prohibits an institution from engaging in certain
transactions with affiliates unless the transactions are on terms substantially the same,
or at least as favorable to such institution, as those prevailing at the time for
comparable transactions with nonaffiliated companies. The Bank is subject to certain
restrictions on extensions of credit to executive officers, directors, certain principal
shareholders, and their related interests. Such extensions of credit (i) must be made on
substantially the same terms, including interest rates and collateral, as those prevailing
at the time for comparable transactions with third parties and (ii) must not involve more
than the normal risk of repayment or present other unfavorable features.

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Dividends.    
          A national bank may not pay dividends from its capital. All dividends must be
          paid out of undivided profits then on hand, after deducting expenses, including
          reserves for losses and bad debts. In addition, a national bank is prohibited
          from declaring a dividend on its shares of common stock until its surplus equals
          its stated capital, unless the bank has transferred to surplus no less than
          one-tenth of its net profits of the preceding two consecutive half-year periods
          (in the case of an annual dividend). The approval of the OCC is required if the
          total of all dividends declared by a national bank in any calendar year exceeds
          the total of its net profits for that year combined with its retained net
          profits for the preceding two years, less any required transfers to surplus. In
          addition, under FDICIA, the banks may not pay a dividend if, after paying the
          dividend, the bank would be undercapitalized. See Capital
          Regulations below.

Branching.    
          National banks are required by the National Bank Act to adhere to branch office
          banking laws applicable to state banks in the states in which they are located.
          Under current Mississippi law, the Banks may open branches throughout
          Mississippi with the prior approval of the OCC. In addition, with prior
          regulatory approval, the Banks are able to acquire existing banking operations
          in Mississippi. Furthermore, federal legislation has recently been passed which
          permits interstate branching. The new law permits out of state acquisitions by
          bank holding companies (subject to veto by new state law), interstate branching
          by banks if allowed by state law, interstate merging by banks, and de novo
          branching by national banks if allowed by state law. See Recent
          Legislative Developments.

Community Reinvestment Act.    The
Community Reinvestment Act requires that, in connection with examinations of financial
institutions within their respective jurisdictions, the Federal Reserve, the FDIC, the
OCC, or the Office of Thrift Supervision shall evaluate the record of the financial
institutions in meeting the credit needs of their local communities, including low and
moderate income neighborhoods, consistent with the safe and sound operation of those
institutions. These factors are also considered in evaluating mergers, acquisitions, and
applications to open a branch or facility.

Other Regulations.    Interest and
certain other charges collected or contracted for by the Banks are subject to state usury
laws and certain federal laws concerning interest rates. The Banks loan operations
are subject to certain federal laws applicable to credit transactions, such as the federal
Truth-In-Lending Act, governing disclosures of credit terms to consumer borrowers; the
Home Mortgage Disclosure Act of 1975, requiring financial institutions to provide
information to enable the public and public officials to determine whether a financial
institution is fulfilling its obligation to help meet the housing needs community it
serves; the Equal Credit Opportunity Act, prohibiting discrimination on the basis of creed
or other prohibited factors in extending credit; the Fair Credit Reporting Act of 1978,
governing the use and provision of information to credit reporting agencies; the Fair Debt
Collection Act, concerning the manner in which consumer debts may be collected by
collection agencies; and the rules and regulations of the various federal agencies charged
with the responsibility of implementing such federal laws. The deposit operations of the
Bank also are subject to the Right to Financial Privacy Act, which imposes a duty to
maintain confidentiality of consumer financial records and prescribes procedures for
complying with administrative subpoenas of financial records, and the Electronic Funds
Transfer Act and Regulation E issued by the Federal Reserve Board to implement that Act,
which governs automatic deposits to and withdrawals from deposit accounts and
customers rights and liabilities arising from the use of automated teller machines
and other electronic banking services.

Capital Regulations.    The federal bank
regulatory authorities have adopted risk-based capital guidelines for banks and bank
holding companies that are designed to make regulatory capital requirements more sensitive
to differences in risk profile among banks and bank holding companies, account for
off-balance sheet exposure, and minimize disincentives for holding liquid assets. The
resulting capital ratios represent qualifying capital as a percentage of total
risk-weighted assets and off-balance sheet items. The guidelines are minimums, and the
federal regulators have noted that banks and bank holding companies contemplating
significant expansion programs should not allow expansion to diminish their capital ratios
and should maintain ratios well in excess of the minimums. The current guidelines require
all bank holding companies and federally-regulated banks to maintain a minimum risk-based
total capital ratio equal to 8%, of which at least 4% must be Tier 1 capital. Tier 1
capital includes common shareholders equity, qualifying perpetual preferred stock,
and minority interests in equity accounts of consolidated subsidiaries, but excludes
goodwill and most other intangibles and excludes the allowance for loan and lease losses.
Tier 2 capital includes the excess of any preferred stock not included in Tier 1 capital,
mandatory convertible securities, hybrid capital instruments, subordinated debt and
intermediate term-preferred stock, and general reserves for loan and lease losses up to
1.25% of risk-weighted assets.

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Under the guidelines, banks and
bank holding companies assets are given risk-weights of 0%, 20%, 50% and 100%. In
addition, certain off-balance sheet items are given credit conversion factors to convert
them to asset equivalent amounts to which an appropriate risk-weight will apply. These
computations result in the total risk-weighted assets. Most loans are assigned to the 100%
risk category, except for first mortgage loans fully secured by residential property and,
under certain circumstances, residential construction loans, both of which carry a 50%
rating. Most investment securities are assigned to the 20% category, except for municipal
or state revenue bonds, which have a 50% rating, and direct obligations of or obligations
guaranteed by the United States Treasury or United States Government agencies, which have
a 0% rating.

The federal bank regulatory
authorities have also implemented a leverage ratio, which is Tier 1 capital as a
percentage of average total assets less intangibles, to be used as a supplement to the
risk-based guidelines. The principal objective of the leverage ratio is to place a
constraint on the maximum degree to which a bank holding company may leverage its equity
capital base. The minimum required leverage ratio for top-rated institutions is 3%, but
most institutions are required to maintain an additional cushion of at least 100 to 200
basis points.

FDICIA established a capital-based
regulatory scheme designed to promote early intervention for troubled banks and requires
the FDIC to choose the least expensive resolution of bank failures. The capital-based
regulatory framework contains five categories of compliance with regulatory capital
requirements, including well capitalized, adequately capitalized,
undercapitalized, significantly undercapitalized, and
critically undercapitalized. To qualify as a well capitalized
institution, a bank must have a leverage ratio of no less than 5%, a Tier 1 risk-based
ratio of no less than 6%, and a total risk-based capital ratio of no less than 10%, and
the Bank must not be under any order or directive from the appropriate regulatory agency
to meet and maintain a specific capital level. As of December 31, 2006, the Company and
The First, were qualified as well capitalized.

Under the FDICIA regulations, the
applicable agency can treat an institution as if it were in the next lower category if the
agency determines (after notice and an opportunity for hearing) that the institution is in
an unsafe or unsound condition or is engaging in an unsafe or unsound practice. The degree
of regulatory scrutiny of a financial institution will increase, and the permissible
activities of the institution will decrease, as it moves downward through the capital
categories. Institutions that fall into one of the three undercapitalized categories may
be required to (i) submit a capital restoration plan; (ii) raise additional capital; (iii)
restrict their growth, deposit interest rates, and other activities; (iv) improve their
management; (v) eliminate management fees; or (vi) divest themselves of all or part of
their operations. Bank holding companies controlling financial institutions can be called
upon to boost the institutions capital and to partially guarantee the
institutions performance under their capital restoration plans.

These capital guidelines can affect
the Company in several ways. If the Company continues to grow at a rapid pace, a premature
squeeze on capital could occur making a capital infusion necessary. The
requirements could impact the Companys ability to pay dividends. The Companys
present capital levels are more than adequate; however, rapid growth, poor loan portfolio
performance, or poor earnings performance could change the Companys capital position
in a relatively short period of time.

Failure to meet these capital
requirements would mean that a bank would be required to develop and file a plan with its
primary federal banking regulator describing the means and a schedule for achieving the
minimum capital requirements. In addition, such a bank would generally not receive
regulatory approval of any application that requires the consideration of capital
adequacy, such as a branch or merger application, unless the Bank could demonstrate a
reasonable plan to meet the capital requirement within a reasonable period of time.

Enforcement Powers.    FIRREA expanded
and increased civil and criminal penalties available for use by the federal regulatory
agencies against depository institutions and certain institution-affiliated
parties (primarily including management, employees, and agents of a financial
institution, independent contractors such as attorneys and accountants, and others who
participate in the conduct of the financial institutions affairs). These practices
can include the failure of an institution to timely file required reports; the filing of
false or misleading information; or the submission of inaccurate reports. Civil penalties
may be as high as $1,000,000 a day for such violations. Criminal penalties for some
financial institution crimes have been increased to twenty years. In addition, regulators
are provided with greater flexibility to commence enforcement actions against institutions
and institution-affiliated parties. Possible enforcement actions include the termination
of deposit insurance. Furthermore, FIRREA expanded the appropriate banking agencies
power to issue cease and desist orders that may, among other things, require affirmative
action to correct any harm resulting from a violation or practice, including restitution,
reimbursement, indemnifications, or guarantees against loss. A financial institution may
also be ordered to restrict its growth, dispose of certain assets, rescind agreements or
contracts, or take other actions as determined by the ordering agency to be appropriate.

# 7

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Effect of Governmental Monetary
Policies.    The earnings of the Bank are affected by domestic economic conditions and the
monetary and fiscal policies of the United States government and its agencies. The Federal
Reserve Boards monetary policies have had, and are likely to continue to have, an
important impact on the operating results of commercial banks through its power to
implement national monetary policy in order, among other things, to curb inflation or
combat a recession. The monetary policies of the Federal Reserve Board have major effects
upon the levels of bank loans, investments, and deposits through its open market
operations in United States government securities and through its regulation of the
discount rate on borrowings of member banks and the reserve requirements against member
bank deposits. It is not possible to predict the nature or impact of future changes in
monetary and fiscal policies.

Significant Legislative Developments.   
On September 29, 1994, the federal government enacted the Riegle-Neal Interstate Banking
and Branching Efficiency Act of 1994 (the Interstate Banking Act). This Act
became effective on September 29, 1995 and permits eligible bank holding companies in any
state, with regulatory approval, to acquire banking organizations in any other state.
Since June 1, 1997, the Interstate Banking Act has allowed banks with different home
states to merge, unless a particular state opts out of the statute. In addition, beginning
June 1, 1997, the Interstate Banking Act has permitted national and state banks to
establish de novo branches in another state if there is a law in that state which applies
equally to all banks and expressly permits all out-of-state banks to establish de novo
branches.

On November 12, 1999, the Gramm-
Leach-Bliley Act of 1999 (the Financial Services Modernization Act) was signed
into law. The Financial Services Modernization Act repeals the two affiliation provisions
of the Glass-Steagall Act: Section 20, which restricted the affiliation of Federal Reserve
Member Banks with firms engaged principally in specified securities
activities; and Section 32, which restricts officer, director, or employee interlocks
between a member bank and any company or person primarily engaged in specified
securities activities. In addition, the Financial Services Modernization Act also contains
provisions that expressly preempt any state law restricting the establishment of financial
affiliations, primarily related to insurance. The general effect of the law is to
establish a comprehensive framework to permit affiliations among commercial banks,
insurance companies, securities firms, and other financial service providers by revising
and expanding the BHCA framework to permit a holding company system to engage in a full
range of financial activities through a new entity known as a Financial Holding Company.
Financial activities is broadly defined to include not only banking,
insurance, and securities activities, but also merchant banking and additional activities
that the Federal Reserve, in consultation with the Secretary of the Treasury, determines
to be financial in nature, incidental to such financial activities, or complementary
activities that do not pose a substantial risk to the safety and soundness of depository
institutions or the financial system generally.

Generally, the Financial
Services Modernization Act:

`        Repeals historical restrictions on, and eliminates many federal and state law barriers to, affiliations
                  among banks, securities firms, insurance companies, and other financial service providers;

                 Provides a uniform framework for the functional regulation of the activities of banks, savings
                  institutions, and their holding companies;

                 Broadens the activities that may be conducted by national banks, banking subsidiaries of bank holding
                  companies, and their financial subsidiaries;

                 Provides an enhanced framework for protecting the privacy of consumer information;

                 Adopts a number of provisions related to the capitalization, membership, corporate governance, and other
                  measures designed to modernize the Federal Home Loan Bank system;

                 Modifies the laws governing the implementation of the Community Reinvestment Act ("CRA"); and

                 Addresses a variety of other legal and regulatory issues affecting both day-to-day operations and
                  long-term activities of financial institutions.`

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In order for a bank holding company
to take advantage of the ability to affiliate with other financial services providers,
that company must become a Financial Holding Company as permitted under an
amendment to the BHCA. To become a Financial Holding Company, the company would file a
declaration with the Federal Reserve, electing to engage in activities permissible for
Financial Holding Companies and certifying that it is eligible to do so because all of its
insured depository institution subsidiaries are well-capitalized and well-managed. In
addition, the Federal Reserve must also determine that each insured depository institution
subsidiary of the Company has at least a satisfactory CRA rating.

The Financial Services Modernization
Act also permits national banks to engage in expanded activities through the formation of
financial subsidiaries. A national bank may have a subsidiary engaged in any activity
authorized for national banks directly or any financial activity, except for insurance
underwriting, insurance investments, real estate investment or development, or merchant
banking, which may only be conducted through a subsidiary of a Financial Holding Company.
Financial activities include all activities permitted under new sections of the BHCA or
permitted by regulation.

A national bank seeking to have a
financial subsidiary, and each of its depository institution affiliates, must be
well-capitalized and well-managed. The total assets of all
financial subsidiaries may not exceed the lesser of 45% of a banks total assets, or
$50 billion. A national bank must exclude from its assets and equity all equity
investments, including retained earnings, in a financial subsidiary. The assets of the
subsidiary may not be consolidated with the banks assets. The bank must also have
policies and procedures to assess financial subsidiary risk and protect the bank from such
risks and potential liabilities.

The Financial Services Modernization
Act also includes a new section of the Federal Deposit Insurance Act governing
subsidiaries of state banks that engage in activities as principal that would only
be permissible for a national bank to conduct in a financial subsidiary. It
expressly preserves the ability of a state bank to retain all existing subsidiaries.
Because Mississippi permits commercial banks chartered by the state to engage in any
activity permissible for national banks, the state bank competitors of The First will be
permitted to form subsidiaries to engage in the activities authorized by the Financial
Services Modernization Act, to the same extent as The First. In order to form a financial
subsidiary, a state bank must be well-capitalized, and the state bank would be subject to
the same capital deduction, risk management and affiliate transaction rules as applicable
to national banks.

During January 2001, the Company made
application and was approved by the Federal Reserve Bank to become a financial holding
company; however, the Company has no current plans to pursue expanded activities under the
Financial Services Modernization Act. The Companys management has not determined at
this time whether it will seek to form a financial subsidiary. The Company is examining
its strategic business plan to determine whether, based on market conditions, the relative
financial conditions of the Company and its subsidiaries, regulatory capital requirements,
general economic conditions, and other factors, the Company desires to utilize any of its
expanded powers provided in the Financial Services Modernization Act.

The Company and the Bank do not
believe that the Financial Services Modernization Act will have a material adverse effect
on operations in the near-term. However, to the extent that it permits banks, securities
firms, and insurance companies to affiliate, the financial services industry may
experience further consolidation. The Financial Services Modernization Act is intended to
grant to community banks certain powers as a matter of right that larger institutions have
accumulated on an ad hoc basis. Nevertheless, this act may have the result of increasing
the amount of competition that the Company and the Bank face from larger institutions and
other types of companies offering financial products, many of which may have substantially
more financial resources than the Company and the Bank.

# 9

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In 2001, the Uniting and
Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct
Terrorism Act of 2001 (USA Patriot Act) was signed into law. The USA Patriot Act broadened
the application of anti-money laundering regulations to apply to additional types of
financial institutions, such as broker-dealers, and strengthened the ability of the U.S.
Government to detect and prosecute international money laundering and the financing of
terrorism. The principal provisions of Title III of the USA Patriot Act require that
regulated financial institutions, including state member banks: (i) establish an
anti-money laundering program that includes training and audit components; (ii) comply
with regulations regarding the verification of the identity of any person seeking to open
an account; (iii) take additional required precautions with non-U.S. owned accounts; and
(iv) perform certain verification and certification of money laundering risk for their
foreign correspondent banking relationships. The USA Patriot Act also expanded the
conditions under which funds in a U.S. interbank account may be subject to forfeiture and
increased the penalties for violation of anti-money laundering regulations. Failure of a
financial institution to comply with the USA Patriot Acts requirements could have
serious legal and reputational consequences for the institution. The Bank has adopted
policies, procedures and controls to address compliance with the requirements of the USA
Patriot Act under the existing regulations and will continue to revise and update its
policies, procedures and controls to reflect changes required by the USA Patriot Act and
implementing regulations.

In July 2002, Congress enacted the
Sarbanes-Oxley Act of 2002, which addresses, among other issues, corporate governance,
auditing and accounting, executive compensation, and enhanced and timely disclosure of
corporate information. Section 404 of the Sarbanes-Oxley Act, and regulations adopted by
the SEC will in the future require the Company to include in its Annual Report, a report
stating managements responsibility to establish and maintain adequate internal
control over financial reporting and managements conclusion on the effectiveness of
the internal controls at year end. Additionally, the Companys independent registered
public accounting firm will in the future be required to attest to and report on
managements evaluation of internal control over financial reporting.

From time to time, various bills are
introduced in the United States Congress with respect to the regulation of financial
institutions. Certain of these proposals, if adopted, could significantly change the
regulation of banks and the financial services industry. The Company cannot predict
whether any of these proposals will be adopted or, if adopted, how these proposals would
affect the Company.

Making or continuing an investment in
securities, including The First Bancshares Common Stock, involves certain risks that
you should carefully consider. The risks and uncertainties described below are not the
only risks that may have a material adverse effect on First Bancshares. Additional risks
and uncertainties also could adversely affect First Bancshares business and results
of operations. If any of the following risks actually occur, First Bancshares
business, financial condition or results of operations could be affected, the market price
for your securities could decline, and you could lose all or a part of your investment.
Further, to the extent that any of the information contained in this Annual Report on Form
10-K constitutes forward-looking statements, the risk factors set forth below also are
cautionary statements identifying important factors that could cause First
Bancshares actual results to differ materially from those expressed in any
forward-looking statements made by or on behalf of First Bancshares .

First Bancshares may be vulnerable to
certain sectors of the economy.

A portion of First Bancshares
loan portfolio is secured by real estate. If the economy deteriorated and depressed real
estate values beyond a certain point, that collateral value of the portfolio and the
revenue stream from those loans could come under stress and possibly require additional
loan loss accruals. First Bancshares ability to dispose of foreclosed real estate at
prices above the respective carrying values could also be impinged, causing additional
losses.

General economic conditions in the
areas where First Bancshares operations or loans are concentrated may adversely
affect our customers  ability to meet their obligations.

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A sudden or severe downturn in the
economy in the geographic markets served by First Bancshares in the state of Mississippi
may affect the ability of First Bancshares customers to meet loan payments
obligations on a timely basis. The local economic conditions in these areas have a
significant impact on First Bancshares commercial, real estate, and construction
loans, the ability of borrowers to repay these loans and the value of the collateral
securing such loans. Changes resulting in adverse economic conditions of First
Bancshares market areas could negatively impact the financial results of First
Bancshares banking operations and its profitability. Additionally, adverse economic
changes may cause customers to withdraw deposit balances, thereby causing a strain on
First Bancshares liquidity.

First Bancshares is subject to a risk
of rapid and significant changes in market interest rates.

First Bancshares assets and
liabilities are primarily monetary in nature, and as a result First Bancshares is subject
to significant risks tied to changes in interest rates. First Bancshares ability to
operate profitably is largely dependent upon net interest income. Unexpected movement in
interest rates markedly changing the slope of the current yield curve could cause First
Bancshares net interest margins to decrease, subsequently decreasing net interest
income. In addition, such changes could adversely affect the valuation of First
Bancshares assets and liabilities.

At present First Bancshares
one-year interest rate sensitivity position is slightly asset sensitive, but a gradual
increase in interest rates during the next twelve months should not have a significant
impact on net interest income during that period. However, as with most financial
institutions, First Bancshares results of operations are affected by changes in
interest rates and First Bancshares ability to manage this risk. The difference
between interest rates charged on interest-earning assets and interest rates paid on
interest-bearing liabilities may be affected by changes in market interest rates, changes
in relationships between interest rate indices, and/or changes in the relationships
between long-term and short-term market interest rates. A change in this difference might
result in an increase in interest expense relative to interest income, or a decrease in
First Bancshares interest rate spread.

Certain changes in interest rates,
inflation, or the financial markets could affect demand for First Bancshares
products and First Bancshares  ability to deliver products efficiently.

Loan originations, and potentially
loan revenues, could be adversely impacted by sharply rising interest rates. Conversely,
sharply falling rates could increase prepayments within First Bancshares securities
portfolio lowering interest earnings from those investments. An unanticipated increase in
inflation could cause First Bancshares operating costs related to salaries &
benefits, technology, & supplies to increase at a faster pace than revenues.

The fair market value of First
Bancshares securities portfolio and the investment income from these securities also
fluctuate depending on general economic and market conditions. In addition, actual net
investment income and/or cash flows from investments that carry prepayment risk, such as
mortgage-backed and other asset-backed securities, may differ from those anticipated at
the time of investment as a result of interest rate fluctuations.

Changes in the policies of monetary
authorities and other government action could adversely affect First Bancshares
profitability.

The results of operations of First
Bancshares are affected by credit policies of monetary authorities, particularly the
Federal Reserve Board. The instruments of monetary policy employed by the Federal Reserve
Board include open market operations in U.S. government securities, changes in the
discount rate or the federal funds rate on bank borrowings and changes in reserve
requirements against bank deposits. In view of changing conditions in the national economy
and in the money markets, particularly in light of the continuing threat of terrorist
attacks and the current military operations in the Middle East, we cannot predict possible
future changes in interest rates, deposit levels, loan demand or First Bancshares
business and earnings. Furthermore, the actions of the United States government and other
governments in responding to such terrorist attacks or the military operations in the
Middle East may result in currency fluctuations, exchange controls, market disruption and
other adverse effects.

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Natural disasters could affect First
Bancshares ability to operate

First Bancshares market areas
are susceptible to natural disasters such as hurricanes. Natural disasters can disrupt
First Bancshares operations, result in damage to properties and negatively affect
the local economies in which First Bancshares operates. First Bancshares cannot predict
whether or to what extent damage caused by future hurricanes will affect First
Bancshares operations or the economies in First Bancshares market areas, but
such weather events could cause a decline in loan originations, a decline in the value or
destruction of properties securing the loans and an increase in the risk of delinquencies,
foreclosures or loan losses.

Greater loan losses than expected may
adversely affect First Bancshares earnings.

First Bancshares as lender is exposed to
the risk that its customers will be unable to repay their loans in accordance with their
terms and that any collateral securing the payment of their loans may not be sufficient to
assure repayment. Credit losses are inherent in the business of making loans and could
have a material adverse effect on First Bancshares operating results. First
Bancshares credit risk with respect to its real estate and construction loan
portfolio will relate principally to the creditworthiness of corporations and the value of
the real estate serving as security for the repayment of loans. First Bancshares
credit risk with respect to its commercial and consumer loan portfolio will relate
principally to the general creditworthiness of businesses and individuals within First
Bancshares local markets.

First Bancshares makes various
assumptions and judgments about the collectibility of its loan portfolio and provide an
allowance for estimated loan losses based on a number of factors. First Bancshares
believes that its current allowance for loan losses is adequate. However, if First
Bancshares assumptions or judgments prove to be incorrect, the allowance for loan
losses may not be sufficient to cover actual loan losses. First Bancshares may have to
increase its allowance in the future in response to the request of one of its primary
banking regulators, to adjust for changing conditions and assumptions, or as a result of
any deterioration in the quality of First Bancshares loan portfolio. The actual
amount of future provisions for loan losses cannot be determined at this time and may vary
from the amounts of past provisions.

First Bancshares may need to rely on
the financial markets to provide needed capital

First Bancshares Common Stock
is listed and traded on the NASDAQ stock market. Although First Bancshares anticipates
that its capital resources will be adequate for the foreseeable future to meet its capital
requirements, at times First Bancshares may depend on the liquidity of the NASDAQ stock
market to raise equity capital. If the market should fail to operate, or if conditions in
the capital markets are adverse, First Bancshares may be constrained in raising capital.
First Bancshares maintains a consistent analyst following; therefore, downgrades in First
Bancshares prospects by an analyst(s) may cause First Bancshares Common Stock
price to fall and significantly limit First Bancshares ability to access the markets
for additional capital requirements. Should these risks materialize, First
Bancshares ability to further expand its operations through internal growth may be
limited.

First Bancshares is subject to
regulation by various Federal and State entities

First Bancshares is subject to the
regulations of the Securities and Exchange Commission (SEC), the Federal
Reserve Board, the Federal Deposit Insurance Corporation, and the OCC. New regulations
issued by these agencies may adversely affect First Bancshares ability to carry on
its business activities. First Bancshares is subject to various Federal and state laws and
certain changes in these laws and regulations may adversely affect First Bancshares
operations.

First Bancshares is also subject to
the accounting rules and regulations of the SEC and the Financial Accounting Standards
Board. Changes in accounting rules could adversely affect the reported financial
statements or results of operations of First Bancshares and may also require extraordinary
efforts or additional costs to implement. Any of these laws or regulations may be modified
or changed from time to time, and First Bancshares cannot be assured that such
modifications or changes will not adversely affect First Bancshares.

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First Bancshares engages in
acquisitions of other businesses from time to time.

On occasion, First Bancshares will
engage in acquisitions of other businesses. Acquisitions may result in customer and
employee turnover, thus increasing the cost of operating the new businesses. The acquired
companies may also have legal contingencies, beyond those that First Bancshares is aware
of, that could result in unexpected costs.

First Bancshares is subject to
industry competition which may have an impact upon its success.

The profitability of First Bancshares
depends on its ability to compete successfully. First Bancshares operates in a highly
competitive financial services environment. Certain competitors are larger and may have
more resources than First Bancshares does. First Bancshares faces competition in its
regional market areas from other commercial banks, savings and loan associations, credit
unions, internet banks, finance companies, mutual funds, insurance companies, brokerage
and investment banking firms, and other financial intermediaries that offer similar
services. Some of First Bancshares nonbank competitors are not subject to the same
extensive regulations that govern First Bancshares or the Bank and may have greater
flexibility in competing for business.

Another competitive factor is that
the financial services market, including banking services, is undergoing rapid changes
with frequent introductions of new technology-driven products and services. First
Bancshares future success may depend, in part, on its ability to use technology
competitively to provide products and services that provide convenience to customers and
create additional efficiencies in First Bancshares operations.

Future issuances of additional
securities could result in dilution of shareholders ownership.

First Bancshares may determine from
time to time to issue additional securities to raise additional capital, support growth,
or to make acquisitions. Further, First Bancshares may issue stock options or other stock
grants to retain and motivate First Bancshares employees. Such issuances of Company
securities will dilute the ownership interests of First Bancshares shareholders.

Anti-takeover laws and certain
agreements and charter provisions may adversely affect share value.

Certain provisions of state and
federal law and First Bancshares articles of incorporation may make it more
difficult for someone to acquire control of First Bancshares. Under federal law, subject
to certain exemptions, a person, entity, or group must notify the federal banking agencies
before acquiring 10% or more of the outstanding voting stock of a bank holding company,
including First Bancshares shares. Banking agencies review the acquisition to
determine if it will result in a change of control. The banking agencies have 60 days to
act on the notice, and take into account several factors, including the resources of the
acquiror and the antitrust effects of the acquisition. There also are Mississippi
statutory provisions and provisions in First Bancshares articles of incorporation
that may be used to delay or block a takeover attempt. As a result, these statutory
provisions and provisions in First Bancshares articles of incorporation could result
in First Bancshares being less attractive to a potential acquiror.

Securities issued by First
Bancshares, including First Bancshares Common Stock, are not FDIC insured.

Securities issued by First Bancshares,
including First Bancshares Common Stock, are not savings or deposit accounts or
other obligations of any bank and are not insured by the FDIC, the Deposit Insurance Fund,
or any other governmental agency or instrumentality, or any private insurer, and are
subject to investment risk, including the possible loss of principal.

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Not Applicable

The First has a main office located
west of the city of Hattiesburg, Mississippi, in Lamar County. The main office is located
in a 13,000 square foot facility which the Company constructed and opened in January 1997
on a two acre plot of land at the southwest corner of U.S. Highway 98 and Old Highway 11.
The First also has a branch office located on Highway 15 North in the city of Laurel,
Mississippi, one on Highway 589 in the city of Purvis, Mississippi, which is in Lamar
County, a fourth office in a 3,300 square foot facility located at the intersection of
Lincoln Road and South 28th Avenue in Hattiesburg, a fifth office located at 3318 Hardy
Street in Hattiesburg, which will be closing on April 11, 2008 and reopening in an 11,700
square foot building located at 110 S. 40th Ave., Hattiesburg, MS, on April 14, 2008, a
sixth office located on Hwy 43 South, Picayune, MS in a 3,800 sq. ft. facility , a seventh
office located at 1126 Jackson Ave in Pascagoula, MS, an eighth office located at Hwy 90
in Bay St. Louis, MS, a ninth location on Border Ave. in Wiggins, MS, as well as a tenth
location located at Hwy 49 and ONeal Rd. in Gulfport, MS.

The Company believes that the
Banks facilities will adequately serve their needs.

From time to time the Company and/or
the Bank may be named as defendants in various lawsuits arising out of the normal course
of business. On October 8, 2007 The First Bancshares, Inc. (the Company) and
its subsidiary, The First, A National Banking Association (the Bank) were
formally named as defendants and served with a First Amended Complaint in litigation
styled Nick D. Welch v. Oak Grove Land Company, Inc., Fred McMurry, David E. Johnson, J.
Douglas Seidenburg, The First, a National Banking Association, The First Bancshares, Inc.,
and John Does 1 through 10, Civil Action No. 2006-236-CV4, pending in the Circuit Court of
Jones County, Mississippi, Second Judicial District (the First Amended
Complaint).

The allegations by Welch against the
Company and the Bank include counts of 1) Intentional Misrepresentation and Omission; 2)
Negligent Misrepresentation and/or Omission; 3) Breach of Fiduciary Duty; 4) Breach of
Duty of Good Faith and Fair Dealing; and 5) Civil Conspiracy. The First Amended Complaint
served by Welch on October 8, 2007 added the Company and the Bank as defendants in this
ongoing litigation. The First Amended Complaint seeks damages from all the defendants,
including $2,420,775.00, annual dividends for the year 2006 in the amount of $.30 per
share, punitive damages, and attorneys fees and costs, and is more fully described
in Form 8-K filed by the Company on October 10, 2007. Each of the Company and the Bank
deny any liability to Welch, and they intend to defend vigorously against this lawsuit.

No matter was submitted to a vote of
security holders during the fourth quarter of the fiscal year covered by this report.

PART II

`ITEM 5.   MARKET FOR REGISTRANT'S COMMON EQUITY, RELATED STOCKHOLDER MATTERS
          AND ISSUER PURCHASES OF EQUITY SECURITIES.`

In response to this Item, the
information contained on page 53 of the Companys Annual Report to Shareholders for
the year ended December 31, 2007, is incorporated herein by reference.

In response to this Item, the
information contained on page 7 of Managements Discussion and Analysis for the year
ended December 31, 2007, is incorporated herein by reference.

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`ITEM 7.   MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND
          RESULTS OF OPERATIONS.`

In response to this Item, the
information contained on pages 6 through 23 of the Companys Annual Report to
Shareholders for the year ended December 31, 2007, is incorporated herein by reference.

Not applicable.

In response to this Item, the
information contained on pages 25 through 52 of the Companys Annual Report to
Shareholders for the year ended December 31, 2007, is incorporated herein by reference.

`ITEM 9.  CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND
         FINANCIAL DISCLOSURE.`

Not applicable.

The Companys principal
executive officer and principal financial officer have concluded, based upon their
evaluation of the Companys disclosure controls and procedures as of December 31,
2007, that the Companys disclosure controls and procedures were effective. During
the quarter ended December 31, 2007, no changes have occurred in the Companys
internal control over financial reporting that have materially affected or are reasonably
likely to materially affect the Companys internal control over financial reporting.

`The First Bancshares, Inc.
                Managements Report on Internal Control Over Financial Reporting`

Management of The First Bancshares,
Inc. and subsidiary (the Company) is responsible for establishing and
maintaining effective internal control over financial reporting. Internal control over
financial reporting is a process designed to provide reasonable assurance regarding the
reliability of financial reporting and the preparation of financial statements for
external purposes in accordance with U.S. generally accepted accounting principles.

Under the supervision and with the
participation of management, including the principal executive officer and principal
financial officer, the Company conducted an evaluation of the effectiveness of internal
control over financial reporting based on the framework in Internal Control 
Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway
Commission. Based on this evaluation, management of the Company has concluded the Company
maintained effective internal control over financial reporting, as such term is defined in
Securities Exchange Act of 1934 Rules 12a-15(f), as of December 31, 2007.

Internal control over financial
reporting cannot provide absolute assurance of achieving financial reporting objectives
because of its inherent limitations. Internal control over financial reporting is a
process that involves human diligence and compliance and is subject to lapses in judgment
and breakdowns resulting from human failures. Internal control over financial reporting
can also be circumvented by collusion or improper management override. Because of such
limitations, there is a risk that material misstatements may not be prevented or detected
on a timely basis by internal control over financial reporting. These inherent
limitations, however, are known features of the financial reporting process. It is
possible, therefore, to design into the process safeguards to reduce, though not
eliminate, this risk.

# 15

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This annual report does not include
an attestation report of the Companys registered public accounting firm regarding
internal control over financial reporting. Managements report was not subject to
attestation by the Companys registered public accounting firm pursuant to temporary
rules of the Securities and Exchange Commission that permit the Company to provide only
managements report in this annual report.

`/s/ David E. Johnson                                        /s/ Dee Dee Lowery
-----------------------------------                        -------------------------------------------
Chairman of the Board and CEO                               Executive VP and Chief Financial Officer
March 28, 2008                                              March 28, 2008`

Not applicable.

PART III

In response to this Item, the
information contained under the captions, Election of Directors and
Additional Information Concerning Directors and Officers of the Companys
Proxy Statement for the Annual Meeting of Shareholders to be held on May 22, 2008, is
incorporated herein by reference.

Code of Ethics

The Companys Board of Directors
has adopted a Code of Ethics that applies to the Companys principal executive
officer, principal financial officer, principal accounting officer, or persons performing
similar functions. A copy of this Code of Ethics can be found at the Companys
internet website at www.thefirstbank.com. The Company intends to disclose any amendments
to its Code of Ethics, and any waiver from a provision of the Code of Ethics granted to
the Companys principal executive officer, principal financial officer, principal
accounting officer, or persons performing similar functions, on the Companys
internet website within five business days following such amendment or waiver. The
information contained on or connected to the Companys internet website is not
incorporated by reference into this Form 10-K and should not be considered part of this or
any other report that we file with or furnish to the SEC.

Audit Committee

The information contained under the
caption Committees of the Board of Directors of the Companys Proxy
Statement for the Annual Meeting of Shareholders to be held on May 22, 2008, is
incorporated herein by reference. The Board of Directors has determined that there is at
least one independent audit committee financial expert, J. Douglas Seidenburg, serving on
the Audit Committee, as the terms independent and audit committee financial expert are
used in pertinent Securities and Exchange Commission laws and regulations.

Corporate Governance

The information contained under the
caption Additional Information Concerning Directors and Officers of the
Companys Proxy Statement for the Annual Meeting of Shareholders to be held on May
22, 2008, is incorporated herein by reference.

In response to this Item, the
information contained under the caption Compensation Discussion and Analysis
of the Companys Proxy Statement for the Annual Meeting of Shareholders to be held on
May 22, 2008, is incorporated herein by reference.

# 16

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`ITEM 12.   SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND
           MANAGEMENT AND RELATED STOCKHOLDER MATTERS.`

In response to this Item, the
information contained under the caption Security Ownership of Certain Beneficial
Owners and Management of the Companys Proxy Statement for the Annual Meeting
of Shareholders to be held on May 22, 2008, is incorporated herein by reference.

In response to this Item, the
information contained under the caption Certain Relationships and Related
Transactions of the Companys Proxy Statement for the Annual Meeting of
Shareholders to be held on May 22, 2008, is incorporated herein by reference.

In response to this Item, the
information contained under the caption Principal Accountant Fees and Services
of the Companys Proxy Statement for the Annual meeting of Shareholders to be held on
May 22, 2008, is incorporated herein by reference.

PART IV

The following exhibits are furnished
(or incorporated by reference):

`Exhibit Number          Description
   --------------          -----------

         3.1               Amended and Restated Articles of Incorporation (incorporated by reference to Exhibit 3.1 to the
                           Company's Registration Statement No. 33-94288 on Form S-1).

         3.2               Bylaws (incorporated by reference to Exhibit 3.2 to the Company's Registration Statement No.
                           33-94288 on Form S-1).

         4.1               Provisions in the Company's Articles of Incorporation and Bylaws defining the rights of holders
                           of the Company's Common Stock (incorporated by reference to Exhibit 4.1 to the Company's
                           Registration Statement No. 33-94288 on Form S-1).

         4.2               Form of Certificate of Common Stock (incorporated by reference to Exhibit 4.2 to the Company's
                           Registration Statement No. 33-94288 on Form S-1).

         10.5              Amended and restated employment agreement dated November 20, 1995, by and between David E.
                           Johnson and the Company (incorporated by reference to Exhibit 10.7 of the Company's Form 10-KSB
                           for the fiscal  year ended December 31, 1995, File No. 33-94288).

         10.6              First Bancshares, Inc. 1997 Stock Option Plan as of March 18, 1997 (incorporated by reference
                           to Exhibit 10.7 of the Company's Form 10-KSB for the fiscal year ended December 31, 1996, File
                           No. 33-94288).

         10.7              Agreement to Repurchase Stock by and among The First Bancshares, Inc., Nick Welch and David
                           Johnson  (incorporated by reference to Exhibit 10.9 to the Company's Registration Statement No.
                           333-102908 on Form S-2).

         13                The Company's 2007 Annual Report

         21                Subsidiaries of the Company

         23                Consent of Independent Registered Public Accounting Firm

         31                Rule 13a-14(a)/15d-14(a) Certifications

         32                Section 1350 Certifications`

# 17

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`SIGNATURES

         In accordance with Section 13 or 15(d) of the Exchange Act, the registrant caused this report to be signed on its
behalf by the undersigned, thereunto duly authorized.

                                                              THE FIRST BANCSHARES, INC.


Date: March 28, 2008                                          By:   /s/ David E. Johnson
                                                                  -------------------------------------------------------
                                                                    David E. Johnson
                                                                    Chief Executive Officer (Principal Executive Officer)

Date: March 28, 2008                                          By:   /s/ Dee Dee Lowery
                                                                  -------------------------------------------------------
                                                                    Dee Dee Lowery
                                                                    Executive VP and Chief Financial Officer
                                                                    (Principal Financial and Principal Accounting Officer)


         In accordance with the Exchange Act, this report has been signed below by the following persons on behalf of the
registrant and in the capacities and on the dates indicated.

SIGNATURES                                           CAPACITIES                             DATE
----------                                           ----------                             ----

/s/ David W. Bomboy                                  Director                                March 28, 2008
-------------------------------------

/s/ Michael Chancellor                               Director                                March 28, 2008
-------------------------------------

/s/ M. Ray "Hoppy" Cole, Jr.                         President and                           March 28, 2008
-------------------------------------                Director

/s/ E. Ricky Gibson                                  Director                                March 28, 2008
-------------------------------------

/s/ Peeler G. Lacey, M.D.                            Director                                March 28, 2008
-------------------------------------

/s/ Charles R. Lightsey                              Director                                March 28, 2008
-------------------------------------

/s/ Fred A. McMurry                                  Director                                March 28 , 2008
-------------------------------------

/s/ Gregory M. Mitchell                              Director                                March 28 , 2008
-------------------------------------

/s/ Ted Parker                                       Director                                March 28, 2008
-------------------------------------

/s/ Gerald C. Patch                                  Director                                March 28, 2008
-------------------------------------

/s/ J. Douglas Seidenburg                            Director                                March 28, 2008
-------------------------------------                Vice-Chairman

/s/ Ralph T. Simmons                                 Director                                March 28, 2008
-------------------------------------

/s/ A. L. Smith                                      Director                                March 28, 2008
-------------------------------------

 /s/ Dennis Pierce                                   Director                                March 28 ,2008
-------------------------------------

 /s/ Andrew D. Stetelman                             Director                                March 28, 2008
-------------------------------------

 /s/ David E. Johnson                                Chairman, CEO                           March 28, 2008
-------------------------------------                Director (Principal
                                                     Executive Officer)


 /s/ Dee Dee Lowery                                  Executive VP & Chief Financial          March 28, 2008
-------------------------------------                Officer (Principal Financial
                                                     and Accounting Officer)`

# 18