Federal Register / Vol. 77, No. 38 / Monday, February 27, 2012 / Notices 11559 

been extended, revised, or implemented 

on or after October 1, 1995, unless it 

displays a currently valid OMB control 

number. 

Proposed Collection: Title: STAR 

METRICS (Science and Technology for 

America’s Reinvestment: Measuring the 

EffecTs of Research on Innovation, 

Competitiveness and Science). Type of 

information Collection Request: 

Extension of OMB number 0925–0616, 

expiration date 03/31/2012. Need and 

Use of Information Collection: The aim 

of STAR METRICS is twofold. The goal 

of STAR METRICS is to continue to 

provide mechanisms that will allow 

participating universities and Federal 

agencies with a reliable and consistent 

means to account for the number of 

scientists and staff that are on research 

institution payrolls, supported by 

federal funds. In subsequent generations 

of the program, it is hoped that STAR 

METRICS will allow for measurement of 

science impact on economic outcomes 

(such as job creation), on knowledge 

generation (such as citations, and 

patents) as well as on social and health 

outcomes. 

Frequency of Response: Quarterly. 

Affected Public: Universities and other 

research institutions. Type of 

Respondents: University administrators. 

The annual reporting burden is as 

follows: 

Estimated Number of Respondent: 

100. Estimated Number of Responses 

per Respondent: 4. Average Burden 

Hours per Response: 2.5. Estimated 

Total Annual Burden Hours Requested: 

1,315. The annualized cost to 

respondents is estimated to be $65,750. 

There are no Capital Costs to report. 

There are no Operating or Maintenance 

Costs to report. 

A.12–1—ESTIMATES OF ANNUAL BURDEN HOURS

Number of 

respondents 

Frequency of 

response 

Average Time 

per response 

(in hours) 

Annual hour 

burden 

Stage I: One time data input ........................................................................... 7 1 45 315 

Stage 2: Ongoing quarterly data input ............................................................ 100 4 2.5 1000 

Total .......................................................................................................... ........................ ........................ ........................ 1315 

Request for Comments: Written 

comments and/or suggestions from the 

public and affected agencies are invited 

on one or more of the following points: 

(1) Whether the proposed collection of 

information is necessary for the proper 

performance of the functioning of the 

National Cancer Institute, including 

whether the information will have 

practical utility; (2) the accuracy of the 

agency’s estimate of the burden of the 

proposed collection of information, 

including the validity of the 

methodology and assumptions used; (3) 

ways to enhance the quality, utility, and 

clarity of the information to be 

collected; and (4) ways to minimize the 

burden of the collection of information 

on those who are to respond, including 

the use of appropriate automated, 

electronic, mechanical, or other 

technological collection techniques or 

other forms of information technology. 

Direct Comments to OMB: Written 

comments and/or suggestions regarding 

the item(s) contained in this notice, 

especially regarding the estimated 

public burden and associated response 

time, should be directed to the 

Attention: NIH Desk Officer, Office of 

Management and Budget, at 

OIRA_submission@omb.eop.gov or by 

fax to 202–395–6974. To request more 

information on the proposed project or 

to obtain a copy of the data collection 

plans and instruments, contact: George 

Chacko, Office of Planning, Analysis, 

and Evaluation, Center for Scientific 

Review, 6701 Rockledge Drive, Suite 

3030, Bethesda, MD 20892 or call nontoll-free at 301–435–1111 or email your 

request, including your address to: 

chackoge@mail.nih.gov. 

Comments Due Date: Comments 

regarding this information collection are 

best assured of having their full effect if 

received within 30 days of the date of 

this publication. 

Dated: February 20, 2012. 

George Chacko, 

Center for Scientific Review, National 

Institutes of Health. 

[FR Doc. 2012–4536 Filed 2–24–12; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Submission for OMB Review; 

Comment Request DERT Extramural 

Grantee Data Collection 

SUMMARY: Under the provisions of 

Section 3507(a)(1)(D) of the Paperwork 

Reduction Act of 1995, the National 

Institute of Environmental Health 

Sciences (NIEHS), the National 

Institutes of Health (NIH) has submitted 

to the Office of Management and Budget 

(OMB) a request for review and 

approval of the information collection 

listed below. This proposed information 

collection was previously published in 

the Federal Register, Vol. 76, No. 202, 

on Wednesday, October 19, 2011, page 

64954 and allowed 60 days for public 

comment. No public comments were 

received. The purpose of this notice is 

to allow an additional 30 days for public 

comment. The National Institutes of 

Health may not conduct or sponsor, and 

the respondent is not required to 

respond to, an information collection 

that has been extended, revised, or 

implemented on or after October 1, 

1995, unless it displays a currently valid 

OMB control number. 

Proposed Collection: Title: DERT 

Extramural Grantee Data Collection. 

Type of Information Collection Request: 

New. Need and Use of Information 

Collection: In order to make informed 

management decisions about its 

research programs and to demonstrate 

the outputs, outcomes and impacts of its 

research programs NIEHS will collect, 

analyze and report on data from 

extramural grantees who are currently 

receiving funding or who have received 

funding in the past on topics such as: 

• Key scientific outcomes achieved 

through the research and the impact on 

the field of environmental health 

science. 

• Contribution of research findings to 

program goals and objectives. 

• Satisfaction with the program 

support received. 

• Challenges and benefits of the 

funding mechanism used to support the 

science. 

• Emerging research areas and gaps in 

the research. 

Information gained from this primary 

data collection will be used in 

conjunction with data from grantee 

progress reports and presentations at 

grantee meetings to inform internal 

programs and new funding initiatives. 


srobinson on DSK4SPTVN1PROD with NOTICES
11560 Federal Register / Vol. 77, No. 38 / Monday, February 27, 2012 / Notices 

Outcome information to be collected 

includes measures of agency-funded 

research resulting in dissemination of 

findings, investigator career 

development, grant-funded knowledge 

and products, commercial products and 

drugs, laws, regulations and standards, 

guidelines and recommendations, 

information on patents and new drug 

applications and community outreach 

and public awareness relevant to 

extramural research funding and 

emerging areas of research. Satisfaction 

information to be collected includes 

measures of satisfaction with the type of 

funding or program management 

mechanism used, challenges and 

benefits with the program support 

received, and gaps in the research. 

Frequency of Response: Once per 

grantee, per NIEHS research portfolio. 

Affected Public: Current or past NIEHS 

grantees. Type of Respondents: 

Principal Investigators with current or 

past NIEHS research or training grants. 

The annual reporting burden is as 

follows: Estimated Number of 

Respondents: 600; Estimated Number of 

Responses per Respondent: 1; Average 

Burden Hours per Response: .5 (30 

minutes); and Estimated Total Annual 

Burden Hours Requested: 100. The 

annualized cost to respondents is 

estimated at: Approximately $17. There 

are no Capital Costs to report. There are 

no Operating or Maintenance Costs to 

report. 

(Note: The following table is acceptable for 

the Respondent and Burden Estimate 

information, if appropriate, instead of the 

text as shown above.) 

Type of respondents 

Estimated 

number of 

respondents 

Estimated 

number of 

responses per 

respondent 

Average 

burden hours 

per response 

(min.) 

Estimated total 

annual burden 

hours 

requested 

NIEHS Grantee ................................................................................................ 600 1 30 100 

Request for Comments: Written 

comments and/or suggestions from the 

public and affected agencies are invited 

on one or more of the following points: 

(1) Whether the proposed collection of 

information is necessary for the proper 

performance of the function of the 

agency, including whether the 

information will have practical utility; 

(2) The accuracy of the agency’s 

estimate of the burden of the proposed 

collection of information, including the 

validity of the methodology and 

assumptions used; (3) Ways to enhance 

the quality, utility, and clarity of the 

information to be collected; and (4) 

Ways to minimize the burden of the 

collection of information on those who 

are to respond, including the use of 

appropriate automated, electronic, 

mechanical, or other technological 

collection techniques or other forms of 

information technology. 

Direct Comments to OMB: Written 

comments and/or suggestions regarding 

the item(s) contained in this notice, 

especially regarding the estimated 

public burden and associated response 

time, should be directed to the: Office 

of Management and Budget, Office of 

Regulatory Affairs, OIRA_submission@

omb.eop.gov or by fax to 202–395–6974, 

Attention: Desk Officer for NIH. To 

request more information on the 

proposed project or to obtain a copy of 

the data collection plans and 

instruments, contact 

Dr. Kristianna Pettibone, Evaluator, 

Program Analysis Branch, NIEHS, NIH, 

530 Davis Dr., Room 3055, Morrisville, 

NC 20560, or call non-toll-free number 

919–541–7752 or email your request, 

including your address to: 

pettibonekg@niehs.nih.gov. 

Comments Due Date: Comments 

regarding this information collection are 

best assured of having their full effect if 

received within 30-days of the date of 

this publication. 

Dated: February 16, 2012. 

Joellen M. Austin, 

Associate Director for Management, NIEHS, 

National Institutes of Health. 

[FR Doc. 2012–4543 Filed 2–24–12; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Government-Owned Inventions; 

Availability for Licensing 

AGENCY: National Institutes of Health, 

Public Health Service, HHS. 

ACTION: Notice. 

SUMMARY: The inventions listed below 

are owned by an agency of the U.S. 

Government and are available for 

licensing in the U.S. in accordance with 

35 U.S.C. 207 to achieve expeditious 

commercialization of results of 

federally-funded research and 

development. Foreign patent 

applications are filed on selected 

inventions to extend market coverage 

for companies and may also be available 

for licensing. 

ADDRESSES: Licensing information and 

copies of the U.S. patent applications 

listed below may be obtained by writing 

to the indicated licensing contact at the 

Office of Technology Transfer, National 

Institutes of Health, 6011 Executive 

Boulevard, Suite 325, Rockville, 

Maryland 20852–3804; telephone: 301– 

496–7057; fax: 301–402–0220. A signed 

Confidential Disclosure Agreement will 

be required to receive copies of the 

patent applications. 

Model Cell Lines With and Without 

AKT1 Mutations Derived From Proteus 

Syndrome Patients 

Description of Technology: The 

Proteus syndrome is a congenital 

disorder characterized by patchy 

overgrowth and hyperplasia (cell 

proliferation) of multiple tissues and 

organs, along with susceptibility to 

developing tumors. It is a rare disorder, 

with incidence of less than one case per 

million, caused by a somatic mutation. 

It is also a mosaic disorder, that is one 

in which cells of the same person have 

different genetic content from one 

another. The NHGRI inventors have 

generated cell lines from patients with 

Proteus syndrome and discovered that a 

somatic activating mutation in the 

serine-threonine kinase AKT1 is 

associated with Proteus syndrome. 

AKT1 is an oncogene and an enzyme 

known to mediate cell proliferation and 

apoptosis (programmed cell death 

process) and has been a target for anticancer therapies. A number of singlecell lines with the AKT1 mutation 

showing increased AKT1 

phosphorylation and their matched 

controls without the mutation have been 

generated. The cell lines can be used to 

screen therapeutic targets for AKT1, for 

study design, as models of Proteus 

syndrome and early stages of cancerous 

conditions. 

Potential Commercial Applications 

• Cell lines generated from patients 

with Proteus syndrome. 

• Obtained a number of single-cell 

lines with the AKT1 mutation and their 

matched controls without the mutation. 


srobinson on DSK4SPTVN1PROD with NOTICES