Chlorpyrifos-Methyl (PC 059102) Dieta ry Exposure and Risk Assessment DP N umbe r : D42 6988



## UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON , 

## D.C. 20460

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION



## M E MORANDUM

Date: September 15

, 2015



## SUBJECT: C hlorp yr ipho s-Met h y l: Acute and Steady State Dietary (Food Only) Exposure and Risk Assessments for the Registration Review Human Hea l th R i sk Assessment



## PC C ode: 059 1 02 

## Petition No.: NA 

## DP Barcode: D426988 

## Re g i s tration Nos .: EPA Reg No

. 264-992 

## Regulatory Actio n : Registration Review 

## Case No.: NA 

## Ri s k Assessment Ty p e : Dietary 

## TXR No. : NA 

## M RID No.: NA 

## CAS No.: 5598

- 13-0 4 0 

## CF R: §180.419



## FROM:

T HRO UG H:

And:



## TO :

Page 1 of34 

### Danette Drew, Chemis Risk Assessment Branch V II Health Effects Division (HED, 7509P)

Thurston Morton (DESAC reviewer)

# O 

# v. , , \ .

, , Julie Yan Alstine (DESAC reviewer)**°"'-~** 

### Dietary Exposu r e Science**Adv sor~**  

### Co i (D

Michael Metzger
, Branch Chief 

# ' J**~** 

# J

Risk Assessment Branch V / VII

# ~ Health Effects Division (HED, 7509P)

Joel Wolf

, Chemical Review Ma n ager Risk Management and Impl ementat i o n Branch II Pesticide Re-evaluation D i vision (7508P)

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 2 of 34 

## Executive Summary

Acute and steady state dietary (food only ) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake D atabase (DEEM

- FCID) Version 3.18 . This software uses 2003

- 2008 food consumption data from the U.S. Department of Agriculture’s (USDA’s) National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). The analyses were conducted in support of the registration review risk assessment for chlorpyrifos

- methyl . This memorandum was reviewed by two peer reviewers of the DESAC (and the entire DESAC on 7/30/2015 ), per DESAC SOP 2012.1.

Chlorpyrifos

- methyl (CPM) [ O,

- O,

- dimethyl O

- (3,5,6

- trichloro

- 2

- pyridyl)] is an organophosphate (OP) insecticide limited to post

- harvest treatment of stored cereals grains (barley, oat, rice , sorghum, and wheat) or treatment of storage facilities (i.e., warehouses , bins) for those grains

. Exposure to CPM in food may occur as a result of consuming treated grains or grains stored in treated areas, or as a result of consuming secondary residues in commodities from livestock that have been fed grains with CPM residues . Exposure is not expected from drinking water as CPM is not expected to enter drinking water sources based on the registered post

- harvest and enclosed container uses. The dietary exposure analyses are partially refined. All food residues used were based upon U. S. Department of Agriculture’s Pesticide Data Program (USDA PDP) monitoring data. Where available, empirical processing and cooking factors were incor porated into the assessments. 100% of the stored grains were assumed to be treated with chlorpyrifos

- methyl (no adjustments for % crop treated ( CT ) are made when usin g PDP monitoring data for blended commodities). Drinking water is not included in the assessments as there is no expectation of CPM entering water from the currently registered uses.

Acute Dietary E xposure Results and Characterization

T he probabilistic acute dietary (food only) exposure assessment for CPM incorporated USDA PDP data, processing and cooking factors, and assumed 100% CT.

The acute dietary exposure estimates are below HED’s level of concern (<100 % the acute population adjusted dose (aPAD )) for the U.S. population and the following population subgroups: all infants (<1 year old), youth 13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years of age . However, at the 99.9th percentile of exposure, acute dietary exposure estimates are abov e HED’s level of concern (>100 % aPAD) for children 1

- 2, children 3

- 5, and children 6

- 12 years of age; the highest exposed child subgroup was children 1

- 2 years at 170% of the aPAD.

Acute dietary exposures were below the level of concern for the children subgroups (and all other population subgroups) at the 99 th 

## and 95 th 

## percentile of exposures. Wheat commodities were the greatest contributor to child dietary exposures.

Steady State Dietary E xposure Results and Characterization

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 3 of 34 

## Organophosphates (OPs) may exhibit a phenomenon known as steady state acetylcholinesterase (AChE) inhibition which is the most sensitive endpoint for all lifestages. After repeated dosing at the same dose, the amount of AChE inhibition from a given dose remains consistent acros s duration. For this reason, a ste ady state point of departure (PO D) was selected for oral exposure
to CPM

. The steady state average dietary (food only) exposure assessment for CPM incorporated USDA PDP data, processing and cooking factors, and assumed 100% CT.

The steady state dietary exposure estimates are below HED’s level of concern (<100 % the steady state population adjusted dose (ss PAD)) for the U.S. population and the following population subgroups: all infants (<1 year old), children 6

- 12, youth 13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years of age . However, at the 99.9th percentile of exposure, acute dietary exposure estimates are above HED’s level of concern (>100 % ss PAD) for children 1

- 2 and 3

- 5 years of age ; the highest exposed child subgroup was children 1

- 2 years at 140% of the

ss PAD.

Steady state dietary exposures are below the level of concern for the children subgroups (and all other population subgroups) at the 99 th 

## and 95 th 

## percentile of exposures. Wheat commodities were the greatest contributor to child dietary exposures.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For the acute and steady state assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no u nreasonable adverse health effects). This dose is referred to as the PAD. The PAD is equivale nt to the point of departure (PO D, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and steady state assessments, HED is con cerned when estimated dietary risk exceeds 100% of the PAD. References that discuss dietary risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21

- JU N

- 2000, web link: http://www.regulations.gov/#!documentDetail;D=EPA

- HQ

- OPP

- 2007

- 0780

- 0001 ; or see SOP 99.6 (20

- AUG

- 1999).

HED has conducted acute and steady state dietary (food only) exposure and risk assessments using DEEM version 3.1 8 for CPM. OPs exhibit a phenomenon known as steady state AChE inhibition. After repeated dosing at the same dose level, the degree of inhibition comes into equilibrium with th e production of new, uninhibited enzyme. OP AChE studies of 2

- 3 weeks generally show the same degree of inhibition as those of longer duration ( i.e. , up to 2 years of exposure). Therefore, a steady state assessment based on 21 days of exposure may be cond ucted in place of the traditional chronic assessment

. For steady state dietary assessments for OP pesticides, the DEEM acute module may be used to conduct two

- day average assessments which uses two

- day food (and water consumptions if drinking water is incl uded) along with the steady state POD. These two

- day average

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### Page 4 of 34 

## assessments provide an estimate of 21

- day (steady state) average daily food (and drinking water if included) exposures. Drinking water was not included in the CPM assessments as residues of CPM are not expected in water based on the current post

- harvest uses. Since the DEEM two

- day average assessment does not capture day to day variation in food residues, it will generally result in higher food

- only exposure estimates than a model that calculates 21

- day rolling averages for food. Although the DEEM two

- day average assessment for CPM may result in higher exposure estimates for food than would a 21

- day average model, the assessment provides an acceptable estimate of steady state exposure for food for use in risk assessment and will not underestimate the risk.
The most recent dietary risk assessment for CPM was conducted on 10/28/99 (S. Levy, Chlorpyrifos

- Methyl: Revised Acute and Chronic Dietary Exposure Analyses

. D259806, D259807).

II. Residue Information

Tolerances for residues of CPM are established under 40 CFR §180.419 for cereal grains, processed grain commodities, and livestock commodities

. The residue of concern for risk assessment and for tolerance enforcement is parent compound chlorpyrifos

- methyl. The current tolerance expression under 40 CFR §180.419 includes the combined residues of chlorpyrifos

methyl and its metabolite TCP (3,5,6

- trichlor

- 2

- pyridinol). TCP should be excluded from the tolerance expression and the risk asses sment as it is not considered a residue of toxicological

concern for CPM uses (E. Doyle 4/1/91 and M. Flood, 4/29/91)

. A potential metabolite of concern, the oxygen analog of CPM, is not expected to occur on food or in the environment, based on the current use pattern for stored grains and grain storage facilities. In addition, f rom 2000 to 2010, PDP tested 7

, 344 food samp les (including rice, oats, milk, butter, cream, and beef and chicken commodities) specifically for the oxygen analog. None of the samples had detectable residues of the oxygen analog. The CPM oxon was not found in livestock tissues in the metabolism stud ies at exaggerated feeding rates. All residues in food are assumed to be parent compound CPM only.

The acute and steady state dietary assessments were refined using residue distributions or point estimates derived from USDA PDP monitoring data for cereal grains and for livestock commodities. PDP data were available for barley, oat, rice and wheat. Wheat data were translated to sorghum commodities. For livestock commodities, PDP data were available for the meat, fat and liver of beef and chicken, and for the meat and fat of pork, as well as for eggs, milk and milkfat (cream/butter). W here available , empirical cooking and processing factors were used.

Attachment 1 summarizes the residue inputs [ data source, processing factors, residue data files (RDFs) used, point est imates, etc.] for the acute and steady state assessments

. Attachment 2 contains the RDFs used.

III. Percent Crop Treated Information

The acute and steady state dietary risk assessments for CPM assumed 100% crop treated (CT)

.

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### Page 5 of 34 

## IV. Drinking Water Data

Because of the current use pattern for CPM ( post

- harvest use on stored grains and inside grain storage facilities), residues in water are not anticip ated and there are no concerns for exposure to CPM through drinking water . Therefore, a quantitative drinking water exposure analysis was not conducted.

V. DEEM

- FCID Program and Consumption Information

Acute and steady state dietary exposure assessments were conducted for CPM using DEEM

FCID, Version 3.18 , which incorporates 2003

- 2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non

- consecu tive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA

- defined food commodities (e.g., apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files d eveloped jointly by USDA/ARS and EPA. For chronic (and cancer) exposure assessment, consumption data are averaged for the entire U.S. population and/or within population subgroups. However, for acute exposure assessment, consumption data are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 years old.

For an acute exposure assessment, individual one

- day food consumption data are used on an individual

- by

- individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple rando m pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for analyses performed at all levels of refinement. However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

For a two

- day average assessment, two

- day average food consumptions are calculated on an individual

- by

- individu al basis. The reported consumption amounts of each food item for each day are added together and then divided by two days. For example, if an individual reports eating 100 grams of apple on the first day and 0 grams of apple on the second day, the two

- da y average consumption amount would be 50 grams/day of apple [(100 grams + 0 grams)/2 days = 50 grams/day]. The resulting two

- day average consumption amount can then be multiplied by a residue point estimate and summed to obtain a total daily pesticide exp osure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a

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### Page 6 of 34 

## percentage of the PAD on both a user (i.e. , only those who reported eating relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for analyses performed at all levels of refinement. However, for deterministic assessments, any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk assessment.

VI. Toxicological Information

CPM is a member of the organophosphate class of pesticides. Like other OPs, the initiating event in the adverse outcome pathway/mode of action (AOP/MOA) for CPM involves inhibition of the enzyme AChE via phosphorylation of the serine residue at the active site of the enzyme. This inhibition leads to accumulation of acetylcholine and ultimately to neurotoxicity in the central and/or peripheral nervous system . For CPM, AChE inhibition is the most sensitive endpoint in the toxicology database in multiple sp ecies, durations, lifestages, and routes. OPs exhibit a phenomenon known as steady state cholinesterase (ChE) inhibition. After repeated dosing at the same dose, the degree of inhibition comes into equilibrium with the production of

new, uninhibited enzy me. At this point, the amount of ChE inhibition at a given dose remains consistent across duration. In general, OPs reach steady state within 2

- 3 weeks but this can vary among OPs.
AChE inhibition is the most sensitive endpoint in the chlorpyrifos

- methyl toxicology database in multiple species, durations, and life stages and is the endpoint used for selection of toxicological points of departure (PODs). The PODs for all routes and durations of exposure for chlorpyrifos

methyl are based on red blood cell ( RBC) ChEI from oral animal studies . For acute and steady state dietary exposures the NOAEL of 1.0 mg/kg/day is based on the rat chronic, sub

- chronic, and developmental studies.

The Food Quality Protection Act (FQPA) Safety Factor (SF) has been retained fo r infants, children, youths, and women of childbearing age for all exposure scenarios due to uncertainty in the human dose

- response relationship for neurodevelopmental effects. For chlorpyrifos

- methyl dietary exposures, a total FQPA Safety Factor (SF) of 3 0X (to account for the uncertainties in the human dose

- response relationship for neurodevelopmental effects and for the lack of a comparative cholinesterase assay (CCA study )) is used. A total uncertainty factor (UF) of 3000X (10X to account for interspec ies extrapolation, 10X for intra

- species variation, and 30X for FQPA SF) is a pplicable.
The toxicological endpoints, points of departure and uncertainty/safety fact ors are summarized in Table 1 below:

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### Page 7 of 34 Table 1. Summary of Toxicological Doses and Endpoints for Chlorpyrifos

- Methyl for Use in Dietary and Non

- Occupational Human Health Risk Assessment

Exposure

Scenario Point of Departure
(mg/kg/day) Study and Toxicological

Effects

Acute Dietary NOAEL = 1.0 mg/kg/day

UF A = 10x

UF H = 10x

FQPA SF = 30x*

acute PAD = 0.00033 mg/kg/day Rat Developmental Study

NOAEL = 1.0 mg/kg/day
LOAEL = 12.5 mg/kg/day, based on inhibition of

RBC cholinesterase

Steady

- State Dietary NOAEL = 1.0 mg/kg/day

UF A = 10x

UF H = 10x

FQPA SF = 30x*

Steady State PAD = 0.00033 mg/kg/day Rat Chronic Study

NOAEL = 1.0 mg/kg/day
LOAEL = 50 mg/kg/day, based on RBC ChE Inhibition

Co

- Critical Study
Rat Developmental Study

Rat Sub

- chronic Study

NOAEL = 1.0 mg/kg/day in both studies

LOAEL = 10.0

- 12.5 mg/kg/day, based on inhibition of

RBC cholinesterase

Cancer (oral, dermal, inhalation) Chlorpyrifos

- methyl is not likely to be carcinogenic to humans.

Explanation of Abbreviations: Point of departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human expos ures. NOAEL =

no

- observed adverse

- effect level. LOAEL = lowes t

- observed adverse

- effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intra

- species). FQPA SF = FQPA Safety Factor. UF DB = data base uncertainty factor. PAD = population adjusted dose (a = acute, ss = steady

- state). RfD = reference dose (a = acute, ss = steady

- state). MOE = margin of exposure. LOC = level of concern.

*30x FQPA safety factor ( SF) for females of child

- bearing age, infants, children, and youths to account for uncertainty in the human dose

response relationship for neurodevelopmental effects as well as the lack of a comparative cholinesterase assay

. The assessment of these life stages will be protective for all other life stages.

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## VII. Results/Discussion

As stated above, for acute and steady state assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM

- FCID analyses estimate the dietary exposure and risk of the U.S. population and various population subgroups. The results reported in Tables 2 and 3 are for the general U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 year of age s

.

Results of Acute Dietary (Food) Exposure and Risk Analysis

The acute dietary exposure estimates are below HED’s level of concern ( < 100 % the acute population adjusted dose (aPAD)) for the U.S. population and the following population subgroups : all infants (<1 year o ld), youth 13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years of age

. However, at the 99.9th percentile of exposure, acute dietary exposure estimates are above HED’s level of concern (>100 % aPAD) for children 1

- 2, children 3

- 5, and children 6

- 12 years of age; the highest exposed child subgroup was children 1

- 2 years at 170% of the aPAD.

Acute dietary exposures are below the level of concern for the children subgroups (and all other population subgroups) at the 99 th 

## and 95 th 

## percentile of exposur es.

Table 2

. Results of Acute Dietary (Food) Exposure and Risk Analysis.

Population Subgroup 1 

### aPAD 2 

### (mg/kg/day) 95 th 

### Percentile 99 th 

### Percentile 99.9 th 

### Percentile

Exposure (mg/kg/day) %

aPAD Exposure

(mg/kg/day) %

aPAD Exposure

(mg/kg/day) %

aPAD General U.S. Population 0.00033 0.000071 22 0.000131 40 0.000282 85 All Infants (<1 year old) 0.00033 0.000104 32 0.000163 49 0.000281 85
Children 1

- 2 years old 0.00033 0.000166 50 0.000244 74 0.000555 170
Children 3

- 5 years old 0.00033 0.000128 39 0.000200 61 0.000501 150
Children 6

- 12 years old 0.00033 0.000093 28 0.000155 47 0.000381 120
Youth 13

- 19 years old 0.00033 0.000057 17 0.000098 30 0.000257 78
Adults 20

- 49 years old 0.00033 0.000043 13 0.000077 23 0.000202 61
Adults 50

- 99 years old 0.00033 0.000036 11 0.000065 20 0.000219 66
Females 13

- 49 years old 0.00033 0.000042 13 0.000073 22 0.000190 58

1 

### Population with the greatest exposure is in bold.

2 

### aPAD = acute population

- adjusted dose.



## Results of Steady State Dietary (Food) Exposure and Risk Analysis

The steady state dietary exposure estimates are below HED’s level of concern (<100 % the steady state population adjusted dose (ss PAD)) for the U.S. population and the following population subgroups: all infants (<1 year old), children 6

- 12, youth 13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years of age . However, at the 99.9th percentile of exposure, acute dietary exposure estimates are above HED’s level of concern (>100 % ss PAD) for children 1

- 2 and 3

- 5 years of age ; the highest exposed child subgroup was children 1

- 2 years at 140% of the

ss PAD.

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### Page 9 of 34 

## Steady state dietary exposures are below the level of concern for the children subgroups (and all other population subgroups) at the 99 th 

## and 95 th 

## percentile of exposures.

Table 3 . Results of Steady State Dietary (Food) Exposure and Risk Analysis.

Population Subgroup 1 

### ssPAD 2 

### (mg/kg/day) 95 th 

### Percentile 99 th 

### Percentile 99.9 th 

### Percentile

Exposure (mg/kg/day) %

aPAD Exposure

(mg/kg/day) %

aPAD Exposure

(mg/kg/day) %

aPAD General U.S. Population 0.00033 0.000068 20 0.000118 36 0.000226 68 All Infants (<1 year old) 0.00033 0.000105 32 0.000152 46 0.000264 80
Children 1

- 2 years old 0.00033 0.000155 47 0.000207 63 0.000446 140
Children 3

- 5 years old 0.00033 0.000114 34 0.000167 51 0.000395 120
Children 6

- 12 years old 0.00033 0.000084 26 0.000130 39 0.000297 90
Youth 13

- 19 years old 0.00033 0.000051 15 0.000082 25 0.000191 58
Adults 20

- 49 years old 0.00033 0.000039 12 0.000065 20 0.000163 50
Adults 50

- 99 years old 0.00033 0.000033 10 0.000055 17 0.000172 52
Females 13

- 49 years old 0.00033 0.000038 12 0.000060 18 0.000143 43

1 

### Population with the greatest exposure is in bold.

2



### . ssPAD = steady state population

- adjusted dose.



## VIII. Characterization of Inputs/Outputs

HED has conducted partially refined acute and steady state dietary (food) exposure and risk

ass essments using DEEM version 3.18 for CPM

. Although the DEEM two

- day average assessments may result in higher exposure estima tes for food than would a 21

- day rolling average assessment, this assessment provide an acceptable estimate of 21

- day (steady state ) average exposure for food for use in risk assessment.

The acute and steady state dietary assessments were refined using USDA PDP monitoring data and, where available, empirical cooking and processing factors . PDP data were available for barley, oat, rice and wheat. For livestock commodities, PDP data were available for the meat, fat and liver of beef and chicken, and for the meat and fat of pork, as well as for eggs, milk and milkfat (cream/butter).

I nput residues for grains were incorporated as residue distribution files (RDFs) or point estimates. Residues for milk, eggs, meat, meat byproducts and fat were entered as point estimates based on half the level of detection ( LOD ) as there were no detectable residues found in PDP livestock commodity samples. Detectable residues were found by PDP in barley grain, rice, wheat grain, and wheat flour. No detectab le residues were found in oats.
Residues in wheat (grain and flour) were the greatest contributor to the risk estimates for children.
See Attachment 1 which details all of the food input assumptions.

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### Page 10 of 34 

## IX. Conclusions

These partially refined dietary analyses demonstrate that the currently registered uses of chlorpyrifos

- methyl on stored grains result in acute and steady state dietary (food) risk estimates that exceed HED’s level of concern for children. HED is confident that the assessment does not underestimate risk to the general U.S. population or any population subgroup.

X. List of Attachments

Attachment 1. Data and Residue Estimates Used in the Dietary Exposure Analyses Attachment 2. Residue Data Files (RDFs) Attachment 3

. Acute and Steady State Residue Input file Attachment 4

. Acute Results File Attachment 5

. Steady State Results File

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### Page 11 of 34 

## Attachment 1. Data and Residue Estimates Used in the Chlorpyrifos

- Methyl Dietary Exposure Analyses

Table A1. 

## Data Source and Residue Estimates

Commodity DEEM Food Form Classification 1 Data Source No. of Detectable Residues / No. of Samples/ 

### Range of

Detects (PPM) 1⁄2 LOQ/LOD

(ppm) Cooking and Processing Factors

(PF) * % CT Anticipated Residue (AR) Estimates (ppm)

Avg. Max. Acute and Steady State

CEREAL GRAINS
Barley bran/flour/pearled B Barley Grain PDP 2002, 2003 31/1175 0.008

- 0.06 0.0025 0.026 boiled 0.36 baked/fried 100 100 0.0029
Oat groats/rolled oats/flour/bran B Oat Grain PDP 2010 0/298

-- 0.010 0.026 boiled 0.36 baked/ fried 100 100 0.01

Oat
bran B Oat Grain PDP 2010 0/298

-- 0.010 0.026 boiled 0.36 baked/ fried 2.8 PF (processing factor; bran) 100 100 0.01

Rice
B Rice PDP 2000, 2001, 2002 7/1362 0.003

- 0.003 0.001 0.026 boiled 0.36 baked/fried 100 100 RDF3 (Rice_White00_02.rdf)
Total Samples=1362

Total Detects=7

Total LODs=1355

Total Zeros=0

Rice bran B Rice PDP 2000, 2001, 2002 7/1362 0.003

- 0.003 0.001 0.026 boiled 0.36 baked/fried 1.7 PF (bran) 100 100 0.001

Sorghum grain B Wheat Grain PDP 2005, 2006 271/1361 0.30

- 2.61 0.0095 0.026 boiled 0.36 baked/fried 100 100 RDF1 (Wheat_Grain.rdf) Total Samples=1361

Total Detects=271

Total LODs=1090

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### Page 12 of 34 Commodity DEEM Food Form Classification 1 Data Source No. of Detectable Residues / No. of Samples/ 

### Range of

Detects (PPM) 1⁄2 LOQ/LOD

(ppm) Cooking and Processing Factors

(PF) * % CT Anticipated Residue (AR) Estimates (ppm)

Avg. Max. Acute and Steady State

Total Zeros=0 Sorghum
syrup B Wheat Grain PDP 2005, 2006 271/1361 0.30

- 2.61 0.0095 100 100 0.0314

Wheat grain B Wheat Grain PDP 2005, 2006 271/1361 0.30

- 2.61 0.0095 0.026 boiled 0.36 baked/fried 100 100 RDF1 (Wheat_Grain.rdf) Total Samples=1361

Total Detects=271

Total LODs=1090

Total Zeros=0

Wheat bran/germ B Wheat Grain PDP 2005, 2006 271/1361 0.30

- 2.61 0.0095 0.026 boiled 0.36 baked/fried 3 PF (germ and bran) 100 100 0.0314

Wheat flour B Wheat Flour PDP 2003, 2004 246/1331 0.032

- 0.181 0.0095 0.026 boiled 0.36 baked/fried 100 100 RDF2 (Wheat_Flour.rdf) Total Samples=1331

Total Detects=246

Total LODs=1085

Total Zeros=0

Triticale flour B Wheat Flour PDP 2003, 2004 246/1331 0.032

- 0.181 0.0095 0.026 boiled 0.36 baked/fried 100 100 RDF2 (Wheat_Flour.rdf) Total Samples=1331

Total Detects=246

Total LODs=1085

Total Zeros=0 LIVESTOCK COMMODITIES

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 13 of 34 Commodity DEEM Food Form Classification 1 Data Source No. of Detectable Residues / No. of Samples/ 

### Range of

Detects (PPM) 1⁄2 LOQ/LOD

(ppm) Cooking and Processing Factors

(PF) * % CT Anticipated Residue (AR) Estimates (ppm)

Avg. Max. Acute and Steady State

Beef/goat/sheep /horse

, meat NA Beef Meat PDP 2009 0/292

-- 0.002 0.002 Beef/goat/sheep, fat NA

Beef Fat PDP 2009 0/292

-- 0.002 0.002 Beef/goat/sheep (meat byproducts, liver, kidney) NA

Beef Liver PDP 2001 0/624

-- 0.0047 0.0047 Milk, fat NA Milk Cream/Butter PDP 2007 0/742

-- 0.0055 0.0055 Milk, non

- fat (non

- fat solids, water, sugar) NA Milk PDP 2004, 2005 0/1485

-- 0.0008 0.0008 Pork, meat NA Pork Meat PDP 2005 0/252

-- 0.0002 0.0002 Pork, fat NA Pork Fat PDP 2005 0/252

-- 0.0005 0.0005 Pork (meat byproducts, liver, kidney) NA Beef Liver PDP 2001 0/624

-- 0.0047 0.0047 Poultry, meat NA Chicken Meat PDP 2006 0/1310

-- 0.0002 0.0002 Poultry, fat

/skin NA Chicken Fat PDP 2001, 2002 0/631

-- 0.0126 0.0126 Poultry (meat byproducts, liver, kidney) NA Chicken Liver PDP 2001, 2002 0/634

-- 0.0126 0.0126 Eggs NA Egg PDP 2010, 2011 0/742

-- 0.0015 0.0015

NB= Not Blended; PB=Partially Blended; B=Blended * For processing and cooking factors, see S. Levy, 1999, Chlorpyrifos

- Methyl: Revised Acute and Chronic Dietary Exposure Analyses

. D259806.

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 14 of 34 GENERAL RESIDUE INFORMATION:

Residue Distribution Files (RDFs): RDFs were created where appropriate in accordance with The USEPA, HED, DESAC guidance document for Dietary Exposure Analysis , November 2011. Translation from commodities with monitoring data to other commodities were also performed where appropriate in accordance with the 9/12/20 02 USEPA SOP 2000.1 ( Guidance for Translation of Field Tr ial Data from Representative Commodities in the Crop Group Regulation to Other Commodities in Each Crop Group/Subgroup, HED Standard Operating Procedure 2000.1 ). The section below briefly summarizes the data source used per commodity . For details regarding how RDFs were created with regard to number of actua l detects, number and level of 1⁄2 LODs (for treated nondetects) and number of zeros (for untreated nondetects), and for the percent crop treated estimates, and other assumptions such as peeling, cooking, or processing factors, please see Table A1 above. For full details o n the source of the processing and cooking factors, see S. Levy, 1999, Chlorpyrifos

- Methyl: Revised Acute and Chronic Dietary Exposure Analyses

. D259806

. Percent Crop Treated (%CT ): 100% CT was assumed; therefore RDFs did not contain any zeros (for untreated nondetects). RDF files contained a combination of actual detectable residues, where present, plus 1⁄2 LOD residues (to represent treated nondetects).

Cereal Grains

The PDP data (2002

- 2003) for barley grain, with detectable residues, wer e used to create a point estimate for barley commodities (which are processed) . Cooking factors were applied to cooked barley commodities.
The PDP data (2010) for oat grain, with no detectable residues, were used to create a point estimate for oat commodities (which are processed) . Cooking factors were applied to cooked oat commodities. The oat grain data were also used to calculate a point estimate for the processed commodity oat bran ; PDP only tested one oat bran sample (2010; no detectable resid ue). A processi ng factor was also used for oat bran.

The PDP data (2000

- 2003) for rice grain, with detectable residues, were used to create RDFs for rice commodities. Cooking factors were applied to cooked rice commodities. Although PDP analyzed rice samp les during the years 200 8

- 2009 , none contained detectable residue levels. The 2000

- 2003 dataset was selected for the assessment since the half LOD was considerably lower than that of the 2008

- 2009 dataset (0.001 ppm vs. 0.053 ppm). The use of
very high LODs from datasets would lead to an overestimate in actual exposure ; t he 2000

- 2003 rice data provides a more realistic estimate of actual residues expected on rice commodities. The PDP rice data were also used to calculate a point estimate for the processe d commodity rice bran. A processing factor was used for rice bran.

The PDP data (2005

- 2006) for wheat grain, with detectable residues, were used to create RDFs for wheat commodities. Point estimates and processing factors were used for wheat germ and wheat bran. The PDP data for wheat flour (2003

- 2004), with detectable residues, were used to create RDFs for wheat and triticale flour. Cooking factors were used for the cooked wheat and triticale commodities.

The wheat grain PDP residue values were translate d to sorghum because the use pattern of CPM is the same and because wheat had more detectable residues than the other cereal grains.
Meat, Milk, Eggs

PDP data (2009; no detects) for beef meat and beef fat w ere used to calculate point estimate s for beef meat and fat. PD P data for beef liver (2001 ; no detects) were used to calculate point estimates for beef meat byproducts, liver and kidney. The residue values for beef commodities were also applie d to goat and sheep commodities.

PDP data (2005; no detects) for pork meat and fat were used to calculate point estimate s for pork meat and fat. The 2001 PDP data for beef liver was translated to pork meat byproducts, liver and kidney.

PDP data for chicken meat (2006; no de tects) were used to calculate a point es timate residue for poultry meat. PDP data for chicken fat (2001

- 2002; no detects) were used to calculate point estimates for poultry fat and poultry skin

.

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 15 of 34 PDP data for chicken liver (2001

- 2002; no detects) were used to calculate point estimates for poultry meat byproducts, liver and kidney.
The PDP data for eggs (2010

- 2011; no detects) were used to calculate a point estimate residue.

The PDP data for but ter, cream (2007; no detects) were used to calculate a point estimate for all milk fat food fo rms. The PDP data for milk (2004

- 2005; no detects) were used to calculate a point estimate for all non

- fat milk food forms.
Typically , for acute assessments of livestock commodities with PDP data, RDFs would be generated and used probabilistically; however , since anticipated residues in PDP are all 1⁄2 LOD (based on no detects and 100% CT) , a point estimate of 1⁄2 LOD was used instead of an RDF constructed of all 1⁄2 LOD values.

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 16 of 34 

## Attachment 2. Residue Data Files (RDFs)

Wheat_Grain.rdf

'ChlorpyrifosMethyl, Created by SAS Program: CreateRDF_031714, 19FEB15

'Subdirectory: G: \

USDA_PDP \ SAS \ Chemicals \ ChlorpyrifosMethyl, RDF Filename=Wheat_Grain.rdf

'Residue=CONCEN, RPF=RPF, Brigetable=BT_Recent, PFactor=PF1, PCT=PCT_Max, LOD Rule=LOD1

'PDP Data: WHGR (2005,2006), Total Samples=1361, Total Detects=271, Total LODs=1090, Total Zeros=0

'MaxPCT=1.000, Avg Residue (Detects)=0.119554, Avg Residue (TOTALS)=0.0314, Avg Residue (Blended, PCT=100)=0.031414, Avg HLOD (NonDetects)=0.0095

T OTALZ=0

TOTALLOD=1090

LODRES=0.0095

2.61

1.081

0.836

0.818

0.792

0.671

0.639

0.614

0.574

0.494

0.479

0.475

0.471

0.465

0.449

0.438

0.421

0.417

0.412

0.396

0.396

0.394

0.391

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 17 of 34 0.39

0.359

0.333

0.315

0.313

0.31

0.303

0.268

0.26

0.257

0.239

0.233

0.231

0.209

0.207

0.206

0.197

0.186

0.178

0.174

0.173

0.17

0.165

0.165

0.163

0.163

0.153

0.153

0.15

0.15

0.149

0.145

0.142

0.141

0.139

0.136

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 18 of 34 0.132

0.128

0.127

0.126

0.124

0.12

0.118

0.117

0.112

0.109

0.109

0.103

0.103

0.102

0.102

0.101

0.098

0.097

0.096

0.095

0.094

0.093

0.093

0.092

0.091

0.09

0.088

0.086

0.086

0.084

0.084

0.08

0.08

0.08

0.078

0.076

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 19 of 34 0.075

0.075

0.072

0.072

0.071

0.07

0.07

0.069

0.069

0.068

0.068

0.068

0.068

0.068

0.068

0.067

0.065

0.064

0.064

0.064

0.063

0.063

0.05

0.032 (153 )



### Wheat_Flour.rdf

'ChlorpyrifosMethyl, Created by SAS Program: CreateRDF_031714, 19FEB15

'Subdirectory: G: \

USDA_PDP \ SAS \ Chemicals \ ChlorpyrifosMethyl, RDF Filename=Wheat_Flour.rdf

'Residue=CONCEN, RPF=RPF, Brigetable=BT_Recent, PFactor=PF1, PCT=PCT_Max, LOD Rule=LOD1

'PDP Data: WFGR (2003,2004), Total Samples=1331, Total Detects=246, Total LODs=1085, Total Zeros=0

'MaxPCT=1.000, Avg Residue (Detects)=0.036399, Avg Residue (TOTALS)=0.0145, Avg Residue (Blended, PCT=100)=0.014472, Avg HLOD (NonDetects)=0.0095

TOTALZ=0

TOTALLO D=1085

LODRES=0.0095

0.181

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 20 of 34 0.133

0.117

0.0944

0.0929

0.0903

0.0833

0.081

0.077

0.077

0.076

0.075

0.073

0.0727

0.071

0.0682

0.068

0.065

0.0633

0.063

0.032 (226)



### Rice_White00_02.rdf

'ChlorpyrifosMethyl, 5MAR15 'Subdirectory: G: \ USDA_PDP \ SAS \ Chemicals \ ChlorpyrifosMethyl, RDF Filename=Rice_White00_02.rdf 'Residue=CONCEN, RPF=RPF, Brigetable=BT_Recent, PFactor=PF1, PCT=PCT_Max, LOD Rule=LOD1 'PDP Data: RIGR,RIOT (2000, 2001, 2002), Total Samples=1362, Total Detects=7, Total LODs=1355, Total Zeros=0 'MaxPCT=1.000, Avg Residue (Detects)=., Avg Residue (TOTALS)=, Avg Residue (Blended, PCT=100)=, Avg HLOD (NonDetects)=0.001 TOTALZ=0 TOTALLOD=1355 LODRES=0.001 0.003 0.003 0.003 0.003 0.003 0.003 0.003

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 21 of 34 

## Attachment 3

. Acute and Steady State Residue Input file

Filename: E: \ chlorpyrifos methyl \ cpfs methyl dietary files \ acute cpfm.r08

Chemical: chlorpyrifos methyl

RfD(Chronic): .00033 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): .00033 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 09

- 02

- 2015/12:43:51 Program ver. 3.16, 03

- 08

- d

Comment: acute and steady state chlorpyrifos methyl

-----------------------------------------------------------------------------------

RDL indice s and parameters for Monte Carlo Analysis:

Index Dist Parameter #1 Param #2 Param #3 Comment

# Code

----- ---- ------------ -------- -------- -------

1 6 E: \ chlorpyrifos methyl \ cpfs methyl dietary files \ ChlorpyrifosM_RDF \ Wheat _Grain.rdf

2 6 E: \ chlorpyrifos methyl \ cpfs methyl dietary files \ ChlorpyrifosM_RDF \ Wheat_Flour.rdf

3 6 E: \ chlorpyrifos methyl \ cpfs methyl dietary files \ ChlorpyrifosM_RDF \ Rice_White00_02.rdf

EPA Crop Commodity Name Def Res Adj.Factors RDLComment

Code Grp (ppm) #1 #2 Pntr

---------- ---- ------------------------------- ---------- ------ ------ --- -------

15 00025000 15 Barley, pearled barley

211

- Cooked; Fresh or N/S; Baked

0.002900 0.360 1.000

212

- Cooked; Fresh or N/S; Boiled

0.002900 0.026 1.000

230

- Cooked; Dried; Cook Meth N/S

0.002900 1.000 1.000

232

- Cooked; Dried; Boiled 0.002900 0.026 1.000

240

- Cooked; Canned; Cook Meth N/S

0.002900 1.000 1.000

242

- Cooked; Canned; Boiled 0.002900 0.026 1.000

1500026000 15 Barley, flour

110

- Uncooked; Fresh or N/S; Cook Meth N/S

0.002900 1.000 1.000

120

- Uncooked; Frozen; Cook Meth N/S

0.002900 1.00 0 1.000

130

- Uncooked; Dried; Cook Meth N/S

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 22 of 34 0.002900 1.000 1.000

210

- Cooked; Fresh or N/S; Cook Meth N/S

0.002900 1.000 1.000

211

- Cooked; Fresh or N/S; Baked

0.002900 0.360 1.000

212

- Cooked; Fresh or N/S; Boiled

0.002900 0.026 1.000

214

- Cooked; Fresh or N/S; Fried/baked

0.002900 0.360 1.000

230

- Cooked; Dried; Cook Meth N/S

0.002900 1.000 1.000

231

- Cooked; Dried; Baked 0.002900 0.360 1.000

232

- Cooked; Dried; Boiled 0.002900 0.026 1.000

240

- Cooked; Canned; Cook Meth N/S

0.002900 1.000 1.000

1500026001 15 Barley, flour

- babyfood

211

- Cooked; Fresh or N/S; Baked

0.002900 0.360 1.000

230

- Cooked; Dried; Cook Meth N/S

0.002900 1.000 1.000

1500027000 15 Barley, bran

211

- Cooked; Fresh or N/S ; Baked

0.002900 0.360 1.000

230

- Cooked; Dried; Cook Meth N/S

0.002900 1.000 1.000

232

- Cooked; Dri ed; Boiled 0.002900 0.026 1.000

1500231000 15 Oat, bran

100

- Uncooked; FF N/A; Cook Meth N/S

0.010000 2.800 1.000

130

- Uncooked; Dried; Cook Me th N/S

0.010000 2.800 1.000

210

- Cooked; Fresh or N/S; Cook Meth N/S

0.010000 2.800 1.000

211

- Cooke d; Fresh or N/S; Baked

0.010000 1.000 1.000

214

- Cooked; Fresh or N/S; Fried/baked

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 23 of 34 0.010000 1.000 1.000

230

- Cooked; Dried; Cook Meth N/S

0.010000 2.800 1.000

231

- Cooked; Dried; Baked 0.010000 1.000 1.000

232

- Cooked; Dried; Boil ed 0.010000 0.073 1.000

1500232000 15 Oat, flour

211

- Cooked; Fresh or N/S; Baked

0.010000 0.360 1.000

230

- Cooked; Dried; Cook Meth N/S

0.010000 1.000 1.000

240

- Cooked; Canned; Cook Meth N/S

0.010000 1.000 1.000

1500232001 15 Oat, flour

- babyfood

230

- Cooked; Dried; Cook Meth N/S

0.010000 1.000 1.000

240

- Cooked; Canned; Cook Meth N/S

0.010000 1.000 1.000

1500233000 15 Oat, groats/rolled oats

110

- Uncooked; Fresh or N/S; Cook Meth N/S

0.010000 1.000 1.000

130

- Uncooked; Dried; Cook Meth N/S

0.010000 1.000 1.000

210

- Cooked; Fresh or N/S; Cook Meth N/S

0.010000 1.000 1.000

211

- Cooked; Fresh or N/S; Baked

0.010000 0.360 1.000

212

- Cooked; Fresh or N/S; Boiled

0.010000 0.026 1.000

213

- Cooked; Fresh or N/S; Fried

0.010000 0.360 1.000

221

- Cooked; Frozen; Baked 0.010000 0.360 1.000

230

- Cooked; Dried; Cook Meth N/S

0.010000 1.000 1.000

231

- Cooked; Dried; Baked 0.010000 0.360 1.000

232

- Cooked; Dried; Boiled 0.010000 0.026 1.000

233

- Cooked; Dried; Fried 0.010000 0.360 1.000

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 24 of 34 1500233001 15 Oat, groats/rolled oats

- babyfood

211

- Cooked; Fresh or N/S; Baked

0.010000 0.360 1.000

240

- Cooked; Canned; Cook Meth N/S

0.010000 1.000 1.000

1500323000 15 Rice, white

100

- Uncooked; FF N/A; Cook Meth N/S

1.000000 1.000 1.000 3

110

- Uncooked; Fresh or N/S; Cook Meth N/S

1.000000 1.000 1.000 3

120

- Uncooked; Frozen; Cook Meth N/S

1.000000 1.000 1.000 3

210

- Cooked; Fresh or N/S; Cook Meth N/S

1.000000 1.000 1.000 3

211

- Cooked; Fresh or N/S; Baked

1.000000 0.360 1.000 3

212

- Cooked; Fresh or N/S; Boiled

1.000000 0.026 1.000 3

213

- Cooked; Fresh or N /S; Fried

1.000000 0.360 1.000 3

215

- Cooked; Fresh or N/S; Boiled/baked

1.000000 0.360 1.000 3

220

- Cooked; Frozen; Cook Meth N/S

1.000000 1.000 1.000 3

221

- Cooked; Frozen; Baked 1.000000 0.360 1.000 3

230

- Cooked; Dried; Coo k Meth N/S

1.000000 1.000 1.000 3

232

- Cooked; Dried; Boiled 1.000000 0.026 1.000 3

233

- Cooked; Dried; Fried 1.000000 0.360 1.000 3

240

- Cooked; Canned; Cook Meth N/S

1.000000 1.000 1.000 3

242

- Cooked; Canned; Boiled 1.000000 0.026 1.000 3

1500323001 15 Rice, white

- babyfood

210

- Cooked; Fresh or N/S; Cook Meth N/S

1.000000 1.000 1.000 3

240

- Cooked; Canned; Cook Meth N/S

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 25 of 34 1.000000 1.000 1.000 3

1500324000 15 Rice, brown

210

- Cooked; Fresh or N/S; Cook Meth N/S

1.000000 1.000 1.000 3

211

- Cooked; Fresh or N/S; Baked

1.000000 0.360 1.000 3

212

- Cooked; Fresh or N/S; Boiled

1.000000 0.026 1.000 3

213

- Cooked; Fresh or N/S; Fried

1.000000 0.360 1.000 3

230

- Cooked; Dried; Cook Meth N/S

1.000000 1.000 1.000 3

232

- Cooked; Dried; Boiled 1.00000 0 0.026 1.000 3

1500324001 15 Rice, brown

- babyfood

230

- Cooked; Dried; Cook Meth N/S

1.000000 1.000 1.000 3

240

- Cooked; Canned; Cook Meth N/S

1.000000 1.000 1.000 3

1500325000 15 Rice, flour

110

- Uncooked; Fresh or N/S; Cook Meth N/S

1.000000 1.000 1.000 3

120

- Uncooked; Frozen; Cook Meth N/S

1.000000 1.000 1.000 3

130

- Uncooked; Dried; Cook Meth N/S

1.000000 1.000 1. 000 3

140

- Uncooked; Canned; Cook Meth N/S

1.000000 1.000 1.000 3

210

- Cooked; Fresh or N/S; Cook Meth N/S

1.000000 1.000 1.000 3

211

- Cooked; Fresh or N/S; Baked

1.000000 0.360 1.000 3

212

- Cooked; Fresh or N/S; Boiled

1.000000 0.026 1.000 3

213

- Cooked; Fresh or N/S; Fried

1.000000 0.360 1.000 3

214

- Cooked; Fresh or N/S; Fried/baked

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 26 of 34 1.000000 0.360 1.000 3

221

- Cooked; Frozen; Baked 1.000000 0.360 1.000 3

222

- Cooked; Frozen; Boiled 1.000000 0.026 1.000 3

223

- Cooked; Frozen; Fr ied 1.000000 0.360 1.000 3

230

- Cooked; Dried; Cook Meth N/S

1.000000 1.000 1.000 3

231

- Cooked; Dried; Baked 1.000000 0.360 1.000 3

232

- Cooked; Dried; Boiled 1.000000 0.026 1.000 3

233

- Cooked; Dried; Fried 1.000000 0.360 1.000 3

240

- Cooked; Canned; Cook Meth N/S

1.000000 1.000 1.000 3

242

- Cooked; Canned; Boiled 1.000000 0.026 1.000 3

250

- Cooked; Cured etc; Cook Meth N/S

1.000000 1.000 1.000 3

251

- Cooked; Cured etc; Baked 1.000000 0.360 1.000 3

252

- Cooked; Cured etc; Boiled 1.000000 0.026 1.000 3

253

- Cooked; Cured etc; Fried 1.000000 0.360 1.000 3

1500325001 15 Rice, flour

- babyfood

110

- Uncooked; Fresh or N/S; Cook Meth N/S

1.000000 1.000 1.000 3

130

- Uncooked; Dried; Cook Meth N/S

1.000000 1.000 1.000 3

211

- Cooked; Fresh or N/S; Baked

1.000000 0.360 1.000 3

230

- Cooked; Dried; Cook Meth N/S

1.000000 1.000 1.000 3

240

- Cooked; Canned; Cook Meth N/S

1.000000 1.000 1.000 3

1500326000 15 Rice, bran

130

- Uncooked; Dried; Cook Meth N/S

0.001000 1.700 1.000

211

- Cooked; Fresh or N/S; Baked

0.001000 0.610 1.000

212

- Cooke d; Fresh or N/S; Boiled

0.001000 0.044 1.000

230

- Cooked; Dried; Cook Meth N/S

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 27 of 34 0.001000 1.700 1.000

1500326001 15 Rice, bran

- babyfood

240

- Cooked; Canned; Cook Meth N/S

0.001000 1.700 1.000

1500344000 15 Sorghum, grain 1.000000 1.000 1.000 1

1500345000 15 Sorgh um, syrup 0.031400 1.000 1.000

1500381000 15 Triticale, flour

211

- Cooked; Fresh or N/S; Baked

1.000000 0.360 1.000 2

230

- Cooked; Dried; Cook Meth N/S

1.000000 1.000 1.000 2

1500401000 15 Wheat, grain

110

- Uncooked; Fresh or N/S; Cook Meth N/S

1.000000 1. 000 1.000 1

120

- Uncooked; Frozen; Cook Meth N/S

1.000000 1.000 1.000 1

210

- Cooked; Fresh or N/S; Cook Meth N/S

1.000000 1.000 1.000 1

211

- Cooked; Fresh or N/S; Baked

1.000000 0.360 1.000 1

212

- Cooked; Fresh or N/S; Boiled

1.000000 0.026 1.000 1

213

- Cooked; Fresh or N/S; Fried

1.000000 0.360 1.000 1

214

- Cooked; Fresh or N/S; Fried/baked

1.000000 0.360 1.000 1

223

- Cooked; Frozen; Fried 1.000000 0.360 1.000 1

230

- Cooked; Dried; Cook Meth N/S

1.000000 1 .000 1.000 1

231

- Cooked; Dried; Baked 1.000000 0.360 1.000 1

232

- Cooked; Dried; Boiled 1.000000 0.026 1.000 1

233

- Cooked; Dried; Fried 1.000000 0.360 1.000 1

240

- Cooked; Canned; Cook Meth N/S

1.000000 1.000 1.000 1

1500401001 15 Wheat, grain

- babyfood

211

- Cooked; Fresh or N/S; Baked

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 28 of 34 1.000000 0.360 1.000 1

230

- Cooked; Dried; Cook Meth N/S

1.000000 1.000 1.000 1

240

- Cooked; Canned; Cook Meth N/S

1.000000 1.000 1.000 1

1500402000 15 Wheat, flour

110

- Uncooked; Fresh or N/S; Cook Meth N/S

1.000000 1.000 1.000 2

120

- Uncooked; Frozen; Cook Meth N/S

1.000000 1.000 1.000 2

130

- Uncooked; Dried; Cook Meth N/S

1.000000 1.000 1.000 2

140

- Uncooked; Canned; Cook Meth N/S

1.000000 1.000 1.000 2

150

- Uncooked; Cured etc; Cook M eth N/S

1.000000 1.000 1.000 2

204

- Cooked; FF N/A; Fried/baked

1.000000 0.360 1.000 2

210

- Cooked; Fres h or N/S; Cook Meth N/S

1.000000 1.000 1.000 2

211

- Cooked; Fresh or N/S; Baked

1.000000 0.360 1.000 2

212

- Cooked; Fresh or N/S; Boiled

1.000000 0.026 1.000 2

213

- Cooked; Fresh or N/S; Fried

1.000000 0.360 1.0 00 2

214

- Cooked; Fresh or N/S; Fried/baked

1.000000 0.360 1.000 2

215

- Cooked; Fresh or N/S; Boiled/baked

1.000000 0.360 1.000 2

220

- Cooked; Frozen; Cook Meth N/S

1.000000 1.000 1.000 2

221

- Cooked; Frozen; Baked 1.000000 0.360 1.000 2

222

- Cooked; Frozen; Boiled 1.000000 0.026 1.000 2

223

- Cooked; Frozen; Fried 1.000000 0.360 1.000 2

224

- Cooked; Frozen; Fried/baked

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 29 of 34 1.0 00000 0.360 1.000 2

230

- Cooked; Dried; Cook Meth N/S

1.000000 1.000 1.000 2

231

- Cooked; Dried; Baked 1.000000 0.360 1.000 2

232

- Cooked; Dried; Boiled 1.000000 0.026 1.000 2

233

- Cooked; Dried; Fried 1.000000 0.360 1.000 2

234

- Cooked; Dried; Fried/baked 1.000000 0.360 1.000 2

240

- Cooke d; Canned; Cook Meth N/S

1.000000 1.000 1.000 2

242

- Cooked; Canned; Boiled 1.000000 0.026 1.000 2

250

- Cooked; Cured etc; Cook Meth N/S

1.000000 1.000 1.000 2

251

- Cooked; Cured etc; Baked 1.000000 0.360 1.000 2

252

- Cooked; Cured etc; Boiled 1.000000 0.026 1.000 2

253

- Coo ked; Cured etc; Fried 1.000000 0.360 1.000 2

921

- Refined; Frozen; Baked 1.000000 0.360 1.000 2

1500402001 15 Wheat, flour

- babyfood

110

- Uncooked; Fresh or N/S; Cook Meth N/S

1.000000 1.000 1.000 2

130

- Uncooked; Dried; Cook Meth N/S

1.000000 1.000 1.000 2

211

- Cooked; Fresh or N/S; Baked

1.000000 0.360 1.000 2

230

- Cooked; Dried; Cook Meth N/S

1.000000 1.000 1.000 2

240

- Cooked; Canned; Cook Meth N/S

1.000000 1.000 1.000 2

1500403000 15 Wheat, germ

211

- Cooked; Fresh or N/S; Baked

0.031400 1.100 1.000

212

- Cooked; Fresh or N/S; Boiled

0.031400 0.078 1.000

230

- Cooked; Dried; Cook Meth N/S

0.031400 1. 000 1.000

232

- Cooked; Dried; Boiled 0.031400 0.078 1.000

1500404000 15 Wheat, bran

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 30 of 34 130

- Uncooked; Dried; Cook Meth N/S

0.031400 1.000 1.000

210

- Cooked; Fresh or N/S; Cook Meth N/S

0.031400 1.000 1.000

211

- Cooked; Fresh or N/S; Baked

0.031400 1.100 1.000

214

- Cooked; Fresh or N/S; Fried/baked

0.031400 1.100 1.000

221

- Cooked; Frozen; Baked 0.031400 1.100 1.000

230

- Cooked; Dried; Cook Meth N/S

0.031400 1.000 1.000

231

- Cooked; Dried; Baked 0.031400 1.100 1.000

3100044000 31 Beef, meat 0.002000 1.000 1.000

3100044001 31 Beef, meat

- babyfood 0.002000 1.000 1.000

3100045000 31 Beef, meat, dried 0.002000 1.000 1.000

3100046000 31 Beef, meat byproducts 0.00 4700 1.000 1.000

3100046001 31 Beef, meat byproducts

- babyfood 0.004700 1.000 1.000

3100047000 31 Beef, fat 0.002000 1.000 1.000

3100047001 31 Beef, fat

- babyfood 0.002000 1.000 1.000

3100048000 31 Beef, kidney 0.004700 1.000 1.000

3100049000 31 Beef, liver 0.004700 1.000 1.000

3100049001 31 Beef, liver

- babyfood 0.004700 1.000 1.000

3200169000 32 Goat, meat 0.002000 1.000 1.000

3200170000 32 Goat, meat byproducts 0.004700 1.000 1.000

3200171000 32 Goat, fat 0.002000 1.000 1.000

3200172000 32 Goat, kidney 0.004700 1.000 1.000

3200173000 32 Goat, liver 0.004700 1.000 1.000

3300189000 33 Horse, meat 0.004700 1.000 1.000

3400290000 34 Pork, meat 0.000200 1.000 1.000

3400290001 34 Pork, meat

- babyfood 0.000200 1.000 1.000

3400291000 34 Pork, skin 0.000500 1.000 1.000

3400292000 34 Pork, meat byproducts 0.004700 1.000 1.000

3400292001 34 Pork, meat byproducts

- babyfood 0.004700 1.000 1.000

3400293000 34 Pork, fat 0.000500 1.000 1.000

3400293001 34 Pork, fat

- babyfood 0 .000500 1.000 1.000

3400294000 34 Pork, kidney 0.004700 1.000 1.000

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 31 of 34 3400295000 34 Pork, liver 0.004700 1.000 1.000

3500339000 35 Sheep, meat 0.002000 1.000 1.000

3500339001 35 Sheep, meat

- babyfood 0.002000 1.000 1.000

3500340000 35 Sheep, meat byproducts 0.004700 1.000 1.000

3500341000 35 Sheep, fat 0.002000 1.000 1.000

3500341001 35 Sheep, fat

- babyfood 0.002000 1.000 1.000

3500342000 35 Sheep, kidney 0.004700 1.000 1.000

3500343000 35 Sheep, liv er 0.004700 1.000 1.000

3600222000 36 Milk, fat 0.005500 1.000 1.000

3600222001 36 Milk, fat

- baby food/infant formu 0.005500 1.000 1.000

3600223000 36 Milk, nonfat solids 0.000800 1.000 1.000

3600223001 36 Milk, nonfat solids

- baby food/in 0.000800 1.000 1.000

3600224000 36 Milk, water 0.000800 1.000 1.000

3600224001 36 Milk, water

- babyfood/infant form 0 .000800 1.000 1.000

3600225001 36 Milk, sugar (lactose)

- baby food/ 0.000800 1.000 1.000

4000093000 40 Chicken, meat 0.000200 1.000 1.000

4000093001 40 Chicken, meat

- babyfood 0.000200 1.0 00 1.000

4000094000 40 Chicken, liver 0.012600 1.000 1.000

4000095000 40 Chicken, meat byproducts 0.012600 1.000 1.000

4000095001 40 Chicken, meat byproducts

- babyfoo 0.012600 1.000 1.000

4000096000 40 Chicken, fat 0.012600 1.000 1.000

4000096001 40 Chicken, fat

- babyfood 0.012600 1.000 1.000

4000097000 40 Chicken, skin 0.012600 1.000 1.000

4000097001 40 Chicken, skin

- babyfood 0.012600 1.000 1.000

5000382000 50 Turkey, meat 0.000200 1.000 1.000

5000382001 50 Turkey, meat

- babyfood 0.000200 1.000 1.000

5000383000 50 Turkey, liver 0.012600 1.000 1.000

5000383001 50 Turkey, liver

- babyfood 0.012600 1.000 1.000

5000384000 50 Turkey, meat byproducts 0.012600 1.000 1.000

5000384001 50 Turkey, meat byprodu cts

- babyfood 0.012600 1.000 1.000

5000385000 50 Turkey, fat 0.012600 1.000 1.000

5000385001 50 Turkey, fat

- babyfood 0.012600 1.000 1.000

5000386000 50 Turkey, skin 0.012600 1.000 1.000

5000386001 50 Turkey, skin

- babyfood 0.012600 1.000 1.000

6000301000 60 Poultry, other, meat 0.000200 1.000 1.000

6000302000 60 Poultry, other, liver 0.012600 1.000 1.000

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 32 of 34 6000303000 60 Poultry, other, meat byproducts 0.012600 1.000 1.000

6000304000 60 Poultry, other, fat 0.012600 1.000 1.000

6000305000 60 Poultry, o ther, skin 0.012600 1.000 1.000

7000145000 70 Egg, whole 0.001500 1.000 1.000

7000145001 70 Egg, whole

- babyfood 0.001500 1.000 1.000

7000146000 70 Egg, white 0.001500 1.000 1.000

7000146001 70 Egg, white (solids)

- babyfood 0.001500 1.000 1.000

7000147000 70 Egg, yolk 0.001500 1.000 1.000

7000147001 70 Egg, yolk

- babyfood 0. 001500 1.000 1.000

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 33 of 34 

## Attachment 4

. Acute Results File

US EPA Ver. 3.18, 03

- 08

- d
DEEM

- FCID ACUTE Analysis for CHLORPYRIFOS METHYL NHANES 2003

- 2008 2

- Day Residue file: acute cpfm.r08 Adjustment factor #2 used. Analysis Date: 09

- 02

- 2015/12:51:11 Residue file dated: 09

- 02

- 2015/12:43:51 RAC/FF intake summed over 24 hours MC iterations = 1000; MC list in residue file; MC seed = 50; RNG = MS VB Run Comment: "acute chlorpyrifos methyl (food)"

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Total US Population: 0.000071 21.48 0.000131 39.63 0.000282 85. 33 All Infants: 0.000104 31.61 0.000163 49.31 0.000281 85.23 Children 1

- 2: 0.000166 50.17 0.000244 74.03 0.000555 168.05 Children 3

- 5: 0.000128 38.88 0.000200 60.66 0.000501 151.87 Children 6

- 12: 0.000093 28.05 0.000155 46.84 0.000381 115.36 Youth 13

- 19: 0.000057 17.17 0.000098 29.67 0.000257 77.86 Adults 20

- 49: 0.000043 13.11 0.000077 23.23 0.000202 61.27 Adults 50

- 99: 0.000036 10.87 0.000065 19.71 0.000219 66.34 Female 13

- 49: 0.000042 12.73 0.000073 22.13 0.000190 57.61

### Chlorpyrifos

- Methyl (PC 059102) Dietary Exposure and Risk Assessment DP Number: D426988



### Page 34 of 34 

## Attachment 5

. Steady State Results File

US EPA Ver. 3.18, 03

- 08

- d

DEEM

- FCID ACUTE Analysis for CHLORPYRIFOS METHYL NHANES 2003

- 2008 2

- Day

Residue file: acute cpfm.r08 Adjustment factor #2 used.

Analysis Date: 09

- 02

- 2015/13:02:36 Residue file dated: 09

- 02

- 2015/12:43:51

Two

- Day Average Results Reported

RAC/FF intake summed over 24 hours

MC iterations = 2000; MC list in residue file; MC seed = 50; RNG = MS VB

Run Comment: "steady state chlorpyrifos methyl (food)"

===============================================================================

Summary calculations

-- per capita:

95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- --------
Total US Population:

0.000068 20.59 0.000118 35.84 0.000226 68.58

All Infants:

0.000105 31.75 0.000152 46.01 0.000264 80.08

Children 1

- 2:

0.000155 47.09 0.000207 62.78 0.000446 135.01

Children 3

- 5:

0.000114 34.59 0.000167 50.62 0.000395 119.57

Children 6

- 12:

0.000084 25.53 0.000130 39.37 0.000297 89.94

Youth 13

- 19:

0.000051 15.43 0.000082 24.71 0.00 0191 57.78

Adults 20

- 49:

0.000039 11.84 0.000065 19.59 0.000163 49.48

Adults 50

- 99:

0.000033 9.96 0.000055 16.78 0.000172 51.97

Female 13

- 49:

0.000038 11.58 0.000060 18.29 0.000143 43.29