Federal Register / Vol. 80, No. 20 / Friday, January 30, 2015 / Notices 5109 

representative species chosen, biological 

and toxicological relevance of the major 

endpoints selected and measured, and 

the validation process used by EPA for 

all four Tier 2 non-mammalian tests 

(Ref. 2). Based on the FIFRA SAP’s 

recommendations and public comments 

received, the EPA revised the test 

protocols (Ref. 3) and developed draft 

test guidelines for the following three 

tests: Japanese quail 2-generation 

toxicity test, Medaka extended 1- 

generation reproduction test, and Larval 

amphibian growth and development 

assay. 

• The Japanese quail 2-generation 

reproduction test features a number of 

core apical endpoints related to 

survival, growth, reproduction and, 

potentially, behavior, as well as more 

pathway-specific endpoints (e.g., 

histopathology). See draft OCSPP Test 

Guideline 890.2100, entitled ‘‘Endocrine 

Disruptor Screening Program Test 

Guidelines; Avian Two-generation 

Toxicity Test in the Japanese Quail.’’ 

• The Medaka extended 1-generation 

reproduction test, developed and 

evaluated primarily by scientists from 

the United States and Japan, starts with 

F0 adults, proceeds through the entire 

F1 generation, and provides an option 

for an entire life cycle exposure of the 

F2 generation. The test, which features 

both pathway-specific (e.g., 

histopathology) and apical (e.g., growth, 

reproduction) endpoints, has been 

successfully evaluated using several 

chemical substances expected to have 

different effects on the hypothalamicpituitary-gonadal (HPG) axis. See draft 

OCSPP Test Guideline 890.2200, 

entitled ‘‘Endocrine Disruptor Screening 

Program Test Guidelines; Medaka 

Extended One Generation Reproduction 

Test (MEOGRT).’’ 

• The Larval amphibian growth and 

development assay is designed to assess 

possible risks of both HPG- and 

hypothalamic-pituitary-thyroid (HPT)- 

active toxicants. The assay, which was 

also developed through a joint effort 

between the United States and Japan, is 

initiated with Nieuwkoop-Faber (NF) 

stage 8 embryos and proceeds through 

NF stage 62 (complete metamorphosis). 

The amphibian test considers a variety 

of both apical and more pathwayspecific endpoints. See draft OCSPP 

Test Guideline 890.2300, entitled 

‘‘Endocrine Disruptor Screening 

Program Test Guidelines; Larval 

Amphibian Growth and Development 

Assay (LAGDA).’’ 

IV. References 

The following is a listing of the 

documents that are specifically 

referenced in this document. The docket 

includes these documents and other 

information considered by EPA, 

including documents that are referenced 

within the documents that are in the 

docket, even if the referenced document 

is not physically located in the docket. 

For assistance in locating these other 

documents, please consult the persons 

listed under FOR FURTHER INFORMATION

CONTACT. 

1. EPA. Endocrine Disruptor Screening 

Program; Proposed Statement of 

Policy; Notice. Federal Register (63 

FR 71542, December 28, 1998) 

(FRL–6052–9). 

2. FIFRA SAP. SAP Minutes No. 2013– 

04. A Set of Scientific Issues Being 

Considered by the Environmental 

Protection Agency Regarding: 

Proposed Endocrine Disruptor 

Screening Program (EDSP) Tier 2 

Ecotoxicity Tests, June 25–28, 2013. 

2013. Docket ID No. EPA–HQ–OPP– 

2013–0182–0084. 

3. EPA. Summary of EPA’s Responses to 

Recommendations of the June 25– 

28, 2013 FIFRA SAP Regarding 

Proposed EDSP Tier 2 NonMammalian Tests. 2014. 

4. EPA. OCSPP Harmonized Ecological 

Effects Test Guideline 850.1350 

(Public Draft): Mysid Chronic 

Toxicity Test, April 1996. EPA 712– 

C–96–166. 1996. Docket ID No. 

EPA–HQ–OPPT–2009–0154. 

Authority: 7 U.S.C. 136 et seq.; 15 U.S.C. 

2601 et seq.; 21 U.S.C. 346a. 

Dated: December 23, 2014. 

Louise P. Wise, 

Acting Assistant Administrator, Office of 

Chemical Safety and Pollution Prevention. 

[FR Doc. 2015–01836 Filed 1–29–15; 8:45 am] 

BILLING CODE 6560–50–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

[ER–FRL–9019–3] 

Environmental Impact Statements; 

Notice of Availability 

AGENCY: Office of Federal Activities, 

General Information (202) 564–7146 or 

http://www.epa.gov/compliance/nepa/. 

Weekly receipt of Environmental Impact 

Statements Filed 01/19/2015 Through 

01/23/2015 Pursuant to 40 CFR 

1506.9. 

Notice 

Section 309(a) of the Clean Air Act 

requires that EPA make public its 

comments on EISs issued by other 

Federal agencies. EPA’s comment letters 

on EISs are available at: http://

www.epa.gov/compliance/nepa/

eisdata.html. 

EIS No. 20150019, Draft EIS, USACE, 

NC, Town of Ocean Isle Beach 

Shoreline Management Project, 

Comment Period Ends: 03/09/2015, 

Contact: Tyler Crumbley 910–251– 

4170 

EIS No. 20150020, Draft EIS, NOAA, 00, 

PROGRAMMATIC—Habitat 

Restoration Activities Implemented 

throughout the Coastal United States, 

Comment Period Ends: 03/20/2015, 

Contact: Frederick Sutter 301–427– 

8600 

EIS No. 20150021, Final EIS, NMFS, 00, 

Recreational Red Snapper Sector 

Separation, Amendment 40 to the 

Fishery Management Plan for the Reef 

Fish Resources of the Gulf of Mexico, 

Review Period Ends: 03/02/2015, 

Contact: Roy Crabtree 727–824–5301 

EIS No. 20150022, Draft Supplement, 

BOEM, 00, Gulf of Mexico Outer 

Continental Shelf (OCS) Oil and Gas 

Lease Sales 2016 and 2017, Central 

Planning Area Lease Sales 241 and 

247; Eastern Planning Area Lease 

Sales 226, Comment Period Ends: 03/ 

16/2015, Contact: Gary Goeke 504– 

736–3233 

EIS No. 20150023, Final Supplement, 

USN, 00, Surveillance Towed Array 

Sensor System Low Frequency Active 

(SURTASS LFA) Sonar Systems, 

Review Period Ends: 03/02/2015, 

Contact: Cynthia Morgan 703–695– 

8266 EIS No. 20150024, Final EIS, 

FHWA, ME, I–395/Route 9 

Transportation System, Review Period 

Ends: 03/02/2015, Contact: Mark 

Hasselmann 207–512–4913 

EIS No. 20150025, Final EIS, FERC, 00, 

Algonquin Incremental Market 

Project, Review Period Ends: 03/02/

2015, Contact: Maggie Suter 202–502– 

6463 

EIS No. 20150026, Final Supplement, 

USFS, WY, Long Term Special Use 

Authorization for Wyoming Game and 

Fish Commission to Use National 

Forest System Lands for their Winter 

Elk Management Activities at Alkali 

Creek Feedground, Review Period 

Ends: 03/16/2015, Contact: Pam Bode 

307–739–5513 

Amended Notices 

EIS No. 20140354, Draft EIS, USACE, 

FL, South Central Palm Beach Island 

Comprehensive Shoreline 

Stabilization Project, Comment Period 

Ends: 02/25/2015, Contact: Garett 

Lips 561–674–2421 

Revision to FR Notice Published 12/12/ 

2014; Extending Comment Period 

from 01/26/2015 to 2/25/2015 


asabaliauskas on DSK5VPTVN1PROD with NOTICES
5110 Federal Register / Vol. 80, No. 20 / Friday, January 30, 2015 / Notices 

Dated: January 27, 2015. 

Cliff Rader, 

Director, NEPA Compliance Division, Office 

of Federal Activities. 

[FR Doc. 2015–01802 Filed 1–29–15; 8:45 am] 

BILLING CODE 6560–50–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

[Docket ID No. EPA–HQ–ORD–2013–0232; 

FRL–9922–21–ORD] 

Draft Integrated Science Assessment 

for Oxides of Nitrogen—Health Criteria 

AGENCY: Environmental Protection 

Agency. 

ACTION: Notice of Public Comment 

Period. 

SUMMARY: The Environmental Protection 

Agency (EPA) is announcing a 60-day 

public comment period for the draft 

document titled, ‘‘Second External 

Review Draft Integrated Science 

Assessment for Oxides of Nitrogen— 

Health Criteria’’ (EPA/600/R–13/005). 

The draft document was prepared by the 

National Center for Environmental 

Assessment (NCEA) within EPA’s Office 

of Research and Development (ORD) as 

part of the review of the primary 

(health-based) National Ambient Air 

Quality Standards (NAAQS) for nitrogen 

dioxide (NO2). The Integrated Science 

Assessment (ISA), in conjunction with 

additional technical and policy 

assessments, provide the scientific basis 

for EPA decisions on the adequacy of 

the current NAAQS and the 

appropriateness of possible alternative 

standards. EPA is developing a separate 

ISA and NAAQS review for the 

secondary (welfare-based) NAAQS for 

NO2, in conjunction with a review of the 

secondary NAAQS for sulfur dioxide 

(78 FR 53452). 

EPA is releasing this draft document 

to seek review by the Clean Air 

Scientific Advisory Committee (CASAC) 

and the public (meeting date and 

location to be specified in a separate 

Federal Register notice). This draft 

document is not final as described in 

EPA’s information quality guidelines, 

and it does not represent and should not 

be construed to represent Agency policy 

or views. EPA will consider any public 

comments submitted in response to this 

notice when revising the document. 

DATES: The 60-day public comment 

period begins January 30, 2015, and 

ends March 31, 2015. Comments must 

be received on or before March 31, 2015. 

ADDRESSES: The ‘‘Second External 

Review Draft Integrated Science 

Assessment for Oxides of Nitrogen— 

Health Criteria’’ will be available 

primarily via the Internet on NCEA’s 

home page under the Recent Additions 

and Publications menus at http://

www.epa.gov/ncea or the public docket 

at http://www.regulations.gov, Docket 

ID: EPA–HQ–ORD–2013–0232. A 

limited number of CD–ROM copies will 

be available. Contact Ms. Marieka Boyd 

by phone: 919–541–0031; fax: 919–541– 

5078; or email: boyd.marieka@epa.gov 

to request a CD–ROM, and please 

provide your name, your mailing 

address, and the document title, 

‘‘Second External Review Draft 

Integrated Science Assessment for 

Oxides of Nitrogen—Health Criteria’’ to 

facilitate processing of your request. 

FOR FURTHER INFORMATION CONTACT: For 

information on the public comment 

period, contact the ORD Docket at EPA’s 

Headquarters Docket Center; telephone: 

202–566–1752; facsimile: 202–566– 

9744; or email: Docket_ORD@epa.gov. 

For technical information, contact Dr. 

Molini Patel, NCEA; telephone: 919– 

541–1492; facsimile: 919–541–1818; or 

email: patel.molini@epa.gov. 

SUPPLEMENTARY INFORMATION: 

I. Information About the Document 

Section 108(a) of the Clean Air Act 

directs the Administrator to identify 

certain pollutants that, among other 

things, ‘‘cause or contribute to air 

pollution which may reasonably be 

anticipated to endanger public health or 

welfare’’ and to issue air quality criteria 

for them. These air quality criteria are 

to ‘‘accurately reflect the latest scientific 

knowledge useful in indicating the kind 

and extent of all identifiable effects on 

public health or welfare which may be 

expected from the presence of [a] 

pollutant in the ambient air. . . .’’ 

Under section 109 of the Act, the EPA 

is then to establish NAAQS for each 

pollutant for which EPA has issued 

criteria. Section 109(d) of the Act 

subsequently requires periodic review 

and, if appropriate, revision of existing 

air quality criteria to reflect advances in 

scientific knowledge on the effects of 

the pollutant on public health or 

welfare. EPA is also required to review 

and, if appropriate, revise the NAAQS, 

based on the revised air quality criteria 

(for more information on the NAAQS 

review process, see http://www.epa.gov/ 

ttn/naaqs/review.html). 

The oxides of nitrogen are one of six 

criteria pollutants for which EPA has 

established NAAQS. Periodically, EPA 

reviews the scientific basis for these 

standards by preparing an ISA (formerly 

called an Air Quality Criteria 

Document). The ISA, in conjunction 

with additional technical and policy 

assessments, provides the scientific 

basis for EPA decisions on the adequacy 

of the current NAAQS and the 

appropriateness of possible alternative 

standards. The CASAC, an independent 

science advisory committee whose 

review and advisory functions are 

mandated by Section 109(d)(2) of the 

Clean Air Act, is charged (among other 

things) with independent scientific 

review of EPA’s air quality criteria. 

On February 10, 2012 (77 FR 7149), 

EPA formally initiated its current 

review of the air quality criteria for the 

health effects of oxides of nitrogen and 

the primary (health-based) NO2 NAAQS, 

requesting the submission of recent 

scientific information on specified 

topics. EPA held a workshop on 

February 29 to March 1, 2012, to gather 

input from scientific experts, both 

internal and external to EPA, as well as 

from the public regarding key science 

and policy issues that will frame the 

review of the health effects of the oxides 

of nitrogen and the primary NO2

NAAQS (77 FR 7149, February 10, 

2012). 

The discussions at this workshop 

guided the development of EPA’s ‘‘Draft 

Plan for Development of the Integrated 

Science Assessment for Nitrogen 

Oxides—Health Criteria,’’ a draft 

‘‘Integrated Review Plan for the Primary 

NAAQS for Nitrogen Dioxide’’ (EPA– 

452/R–14–003) (IRP), and initial draft 

materials for the development of the 

ISA. The draft plan for the development 

of the ISA was made available for public 

comment on May 3, 2013 (78 FR 26026), 

and was discussed by CASAC via a 

publicly accessible teleconference 

consultation on June 5, 2013 (78 FR 

27234, May 9, 2013). On June 11, 2013, 

EPA held a workshop to discuss, with 

invited scientific experts, initial draft 

materials prepared for the development 

of the ISA (78 FR 27374, May 10, 2013). 

The draft IRP was made available in 

February 2014 for public comment and 

CASAC review (79 FR 7184, February 6, 

2014). The IRP was reviewed by CASAC 

at a public meeting on March 12, 2014 

(79 FR 8701, February 13, 2014). The 

final IRP was released in June 2014 (79 

FR 36801, June 30, 2014), and is 

available at: http://www.epa.gov/ttn/

naaqs/standards/nox/s_nox_2012_

pd.html. 

Comments on the draft plan for the 

ISA and discussion at the June 11, 2013, 

workshop guided development of the 

‘‘First External Review Draft Integrated 

Science Assessment for Oxides of 

Nitrogen—Health Criteria,’’ which was 

released on November 22, 2013 (78 FR 

70040), and is available at: http://

cfpub.epa.gov/ncea/isa/recor

display.cfm?deid=259167. The CASAC 


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