11138 Federal Register / Vol. 77, No. 37 / Friday, February 24, 2012 / Notices 

mouse. J Proteome Res. 2010 Aug 

6;9(8):4176–4188. [PMID 20540569] 

Intellectual Property: HHS Reference 

No. E–172–2011/0—U.S. Provisional 

Application No. 61/507,573 filed 13 Jul 

2011. 

Licensing Contact: Suryanarayana 

(Sury) Vepa, Ph.D., J.D.; 301–435–5020; 

vepas@mail.nih.gov. 

Biomarkers for Niemann-Pick Disease 

Type C and Related Disorders of 

Oxysterol Accumulation 

Description of Technology: NiemannPick disease type C (NPC) is a lethal 

lysosomal storage disorder characterized 

by liver disease and progressive 

neurodegeneration. Lysosomal storage is 

impaired by oxidized cholesterol 

(oxysterol) accumulation. Presenting 

signs and symptoms are nonspecific, 

and the diagnosis is frequently difficult 

and delayed. The inventors established 

a rapid ELISA assay to evaluate 

biomarker levels in serum. The ELISA 

assay tests a novel combination of two 

biomarkers significantly elevated in 

NPC patients, Cathepsin D and Galectin3. Other diseases can cause oxysterol 

accumulation, including other 

lysosomal storage diseases, cholesterol 

trafficking diseases, and 

neurodegenerative diseases. At least for 

the lysosomal storage diseases, the 

combination of elevated Cathepsin D 

and Galectin-3 appears specific for NPC. 

Cathepsin D is a lysosomal enzyme 

involved in protein degradation. The 

secreted Galectin-3 is mostly known as 

a chemoattractant for immune cells. 

Potential Commercial Applications: 

• NPC diagnosis. 

• NPC patient disease progression 

monitoring. 

• NPC therapeutic efficacy testing in 

Clinical Trials. 

• Application of above methods to 

related diseases. 

Competitive Advantages: 

• Fast and non-invasive ELISA serum 

assay. 

• Potential for high sensitivity. 

• Cost effective. 

Development Stage: 

• Pilot. 

• Early-stage. 

• In vivo data available (animal). 

• In vivo data available (human). 

Inventor: Forbes D. Porter (NICHD). 

Intellectual Property: HHS Reference 

No. E–302–2011/0—U.S. Provisional 

Application No. 61/576,062 filed 15 Dec 

2011. 

Licensing Contact: Betty B. Tong, 

Ph.D.; 301–594–6565; 

tongb@mail.nih.gov. 

Dated: February 21, 2012. 

Richard U. Rodriguez, 

Director, Division of Technology Development 

and Transfer, Office of Technology Transfer, 

National Institutes of Health. 

[FR Doc. 2012–4310 Filed 2–23–12; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Center for Scientific Review; Notice of 

Closed Meetings 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meetings. 

The meetings will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; Shared High 

End Instrumentation: NMR and X-ray. 

Date: March 13–14, 2012. 

Time: 7 a.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892, 

(Virtual Meeting). 

Contact Person: Kathryn M Koeller, Ph.D., 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 4166, 

MSC 7806, Bethesda, MD 20892, 301–435– 

2681, koellerk@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; Small 

Business: Hematology. 

Date: March 13–14, 2012. 

Time: 11:30 a.m. to 6 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892, 

(Virtual Meeting). 

Contact Person: Bukhtiar H Shah, DVM, 

Ph.D., Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 4120, 

MSC 7802, Bethesda, MD 20892, (301) 301 

806–7314, shahb@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; P 41 

Competitive Revision. 

Date: March 14, 2012. 

Time: 11 a.m. to 4 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892, 

(Virtual Meeting). 

Contact Person: Khalid Masood, Ph.D., 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 5120, 

MSC 7854, Bethesda, MD 20892, 301–435– 

2392, masoodk@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; Small 

Business: Basic and Integrative 

Bioengineering. 

Date: March 21, 2012. 

Time: 11 a.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: General Services Administration 

(GSA), 301 7th Street SW., 1511, Washington, 

DC 20407. 

Contact Person: Ross D. Shonat, Ph.D., 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 6172, 

MSC 7892, Bethesda, MD 20892, 301–435– 

2786, ross.shonat@nih.hhs.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; PAR10–225: 

Program Project: Center for Macromolecular 

Modeling and Bioinformatics. 

Date: March 21–23, 2012. 

Time: 7 p.m. to 12 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: University of Illinois at UrbanaChampaign, Urbana-Champaign, IL. 

Contact Person: Nitsa Rosenzweig, Ph.D., 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 1102, 

MSC 7760, Bethesda, MD 20892, (301) 435– 

1747, rosenzweign@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; RFA Panel: 

Developmental System Biology. 

Date: March 22–23, 2012. 

Time: 8 a.m. to 5:30 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892, 

(Virtual Meeting). 

Contact Person: Raya Mandler, Ph.D., 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 5217, 

MSC 7840, Bethesda, MD 20892, 301–402– 

8228, rayam@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; Small 

Business: Basic and Integrative 

Bioengineering. 

Date: March 22, 2012. 

Time: 11 a.m. to 9 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: General Services Administration, 

Washington DC, 301 7th Street SW., 1511, 

Washington, DC 20407. 

Contact Person: David R Filpula, Ph.D., 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 6181, 

MSC 7892, Bethesda, MD 20892, 301–435– 

2902, filpuladr@mail.nih.gov. 


srobinson on DSK4SPTVN1PROD with NOTICES
Federal Register / Vol. 77, No. 37 / Friday, February 24, 2012 / Notices 11139 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; Fellowship: 

Cell Biology and Development. 

Date: March 23–29, 2012. 

Time: 11 a.m. to 1:30 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892. 

Contact Person: Kenneth Ryan, Ph.D., 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 3218, 

MSC 7717, Bethesda, MD 20892, 301–435– 

1789, kenneth.ryan@nih.hhs.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.306, Comparative Medicine; 

93.333, Clinical Research, 93.306, 93.333, 

93.337, 93.393–93.396, 93.837–93.844, 

93.846–93.878, 93.892, 93.893, National 

Institutes of Health, HHS) 

Dated: February 17, 2012. 

Jennifer S. Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2012–4345 Filed 2–23–12; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

National Institute of Mental Health 

Notice of Closed Meeting 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meeting. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Institute of 

Mental Health Special Emphasis Panel; 

Fellowships and Dissertation Grants 

Date: March 9, 2012 

Time: 1 p.m. to 4 p.m. 

Agenda: To review and evaluate grant 

applications 

Place: National Institutes of Health, 

Neuroscience Center, 6001 Executive 

Boulevard, Rockville, MD 20852, (Telephone 

Conference Call) 

Contact Person: David W. Miller, Ph.D., 

Scientific Review Officer, Division of 

Extramural Activities, National Institute of 

Mental Health, NIH, Neuroscience Center, 

6001 Executive BLVD, Room 6140, MSC 

9608, Bethesda, MD 20892–9608, 301–443– 

9734, millerda@mail.nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.242, Mental Health Research 

Grants; 93.281, Scientist Development 

Award, Scientist Development Award for 

Clinicians, and Research Scientist Award; 

93.282, Mental Health National Research 

Service Awards for Research Training, 

National Institutes of Health, HHS) 

Dated: February 17, 2012. 

Jennifer S. Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2012–4342 Filed 2–23–12; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Eunice Kennedy Shriver National 

Institute of Child Health and Human 

Development; Notice of Closed 

Meetings 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of a meeting of the 

following meetings. 

The meeting will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: National Institute of 

Child Health and Human Development Initial 

Review Group; Populations Sciences 

Subcommittee. 

Date: March 15–16, 2012. 

Time: 8 a.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: Residence Inn Bethesda, 7335 

Wisconsin Avenue, Bethesda, MD 20814. 

Contact Person: Carla T. Walls, Ph.D., 

Scientific Review Officer, Division of 

Scientific Review, Eunice Kennedy Shriver 

National Institute of Child Health and 

Human Development, NIH, 6100 Executive 

Blvd., Room 5B01, Bethesda, MD 20892, 

301–435–6898, wallsc@mail.nih.gov. 

(Catalogue of Federal Domestic Assistance 

Program Nos. 93.864, Population Research; 

93.865, Research for Mothers and Children; 

93.929, Center for Medical Rehabilitation 

Research; 93.209, Contraception and 

Infertility Loan Repayment Program, National 

Institutes of Health, HHS) 

Dated: February 17, 2012. 

Jennifer S. Spaeth, 

Director, Office of Federal Advisory 

Committee Policy. 

[FR Doc. 2012–4341 Filed 2–23–12; 8:45 am] 

BILLING CODE 4140–01–P 

DEPARTMENT OF HEALTH AND 

HUMAN SERVICES 

National Institutes of Health 

Center for Scientific Review; Notice of 

Closed Meetings 

Pursuant to section 10(d) of the 

Federal Advisory Committee Act, as 

amended (5 U.S.C. App.), notice is 

hereby given of the following meetings. 

The meetings will be closed to the 

public in accordance with the 

provisions set forth in sections 

552b(c)(4) and 552b(c)(6), Title 5 U.S.C., 

as amended. The grant applications and 

the discussions could disclose 

confidential trade secrets or commercial 

property such as patentable material, 

and personal information concerning 

individuals associated with the grant 

applications, the disclosure of which 

would constitute a clearly unwarranted 

invasion of personal privacy. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; RFA–OD– 

11–002: Building Interdisciplinary Research 

Careers in Women’s Health K12s. 

Date: March 12, 2012. 

Time: 8 a.m. to 5 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: Hyatt Regency Bethesda, One 

Bethesda Metro Center, 7400 Wisconsin 

Avenue, Bethesda, MD 20814. 

Contact Person: Denise Wiesch, Ph.D., 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 3150, 

MSC 7770, Bethesda, MD 20892, (301) 435– 

0684, wieschd@csr.nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; ‘‘Genetics 

and Epigenetics of Disease.’’ 

Date: March 13, 2012. 

Time: 12 p.m. to 2:30 p.m. 

Agenda: To review and evaluate grant 

applications. 

Place: National Institutes of Health, 6701 

Rockledge Drive, Bethesda, MD 20892, 

(Virtual Meeting). 

Contact Person: Ronald Adkins, Ph.D., 

Scientific Review Officer, Center for 

Scientific Review, National Institutes of 

Health, 6701 Rockledge Drive, Room 2206, 

MSC 7890, Bethesda, MD 20892, 301–495– 

4511, ronald.adkins@nih.gov. 

Name of Committee: Center for Scientific 

Review Special Emphasis Panel; 

Translational Research in Diabetes, Obesity 

and Endocrine Disorders. 

Date: March 14, 2012. 

Time: 8 a.m. to 6 p.m. 


srobinson on DSK4SPTVN1PROD with NOTICES