Diflubenzuron (PC Code I 0820 I) Dietary Exposure and Risk Assessment DP #: 407784 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

Office of Cbemical Safety and Pollution Prevention 

MEMORANDUM 

December 12, 20 13 

SUBJECT: Diflubenzuron Chronic Non-Cancer and Cancer Dietary and Drinking Water 

Exposure and Risk Assessments for the Amended Use on the Citrus Crop Group. 

PC Code: 108201 DP Barcode: 407784 

Decision No.: 465093 Registration No.: 400-461, 400-466, 400-487 

Petition No.: 2F80 15 Regulatory Action: Section 3 

Risk Assessment Type: Dietary Case No.: 0144 

TXR No.: NA CAS No: 35367-38-5 

MRID No.: NA 4~CFR: 80.377 

Reviewer: Thurston G. Morton, Chemist -:Y{~·· Risk Assessment Branch IV/Healt Effe.cts Division (RABIV/HED; 7509P) 

Through: Sheila Piper, Chemist 

Seyed Tadayon, Chemist 

Dietary Exposure Science 

¥----

TO: 

visory Council (DESAC) 

And 

~ Susan V. Hummel, Senior Chemist 

RABIV/HED (7509P) 

Rita Kumar 

Insecticide/Rodenticide Branch!RD (7505P) 

This document provides a chronic non-cancer and cancer dietary and drinking water risk analysis 

of exposures resulting from use of diflubenzuron. This assessment supports a Section 3 request 

to add the remaining crops for a Citrus Crop Group Tolerance. 

Page 1 of22 
Diflubenzuron (PC Code I 0820 I) Dietary Exposure and Risk Assessment DP #: 407784 

Executive Summary 

The purpose of this memorandum is to report the results of a chronic non-cancer and cancer 

dietary exposure analysis for a Section 3 request for use of the insecticide diflubenzuron on the 

citrus crop group. The chronic non-cancer and cancer dietary risk assessment was conducted 

using the Dietary Exposure Evaluation Model software with the Food Commodity Intake 

Database (DEEM-FCIDTM), Version 3.16, which incorporates consumption data from USDA's 

National Health and Nutrition Examination Survey, What We Eat in America, 

(NHANES!WWEIA). 

This memorandum was reviewed by two peer reviewers of the DESAC, per DESAC Standard 

Operating Procedures (SOP) 2012.1. 

Acute Dietary Exposure Results and Characterization 

No toxic effects attributable to a single (i.e., acute) exposure to diflubenzuron have been 

identified; therefore, an acute reference dose (RID) has not been established for diflubenzuron 

and an acute dietary exposure assessment has not been conducted. 

Chronic Dietary Exposure Results and Characterization 

The slightly refined chronic dietary risk assessment for diflubenzuron shows that chronic dietary 

risk estimates do not exceed HED's level of concern (i.e. <1 00% chronic population adjusted 

doses (cPAD)). The results of the analysis indicate that chronic risk from the dietary (food + 

drinking water) exposure to diflubenzuron will not exceed HED's level of concern for the 

general U.S. population, and all population subgroups. The chronic dietary risk estimate for the 

highest reported exposed population subgroup, children 1-2 years old, is 38% of the cPAD. The 

general US population utilizes 11% of the cP AD. 

Cancer 

Diflubenzuron is classified as "Group E," evidence of non-carcinogenicity for humans, therefore, 

a dietary cancer assessment is not required. However, metabolites CPU and PCA are considered 

probable carcinogens and have Q*s assigned to them. Individual cancer dietary exposure 

analyses were conducted for each metabolite. 

The cancer assessment for PCA includes food only (not present in drinking water). For PCA, the 

cancer dietary exposure estimate for the U.S. population is 1 x 10-6. The cancer assessment for 

CPU includes milk and water only. For CPU, the cancer dietary exposure estimate for the U.S. 

population is 3 X 1 0"6

. 

Page 2 of22 
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

Page 3 of 22

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to point 

of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-

AUG-1999).

Diflubenzuron had a previous dietary risk assessment conducted (B. Hanson, D337826, 4/16/07).

II. Residue Information

Diflubenzuron Use:

In this analysis the chronic dietary exposure and risk estimates resulting from food intake were 

determined for the general U.S. population and various population subgroups resulting from the 

addition of remaining crop commodities in the citrus crop group to the existing food uses for 

diflubenzuron.

Diflubenzuron (N-[((4-chlorophenyl)amino)carbonyl]-2,6-difluorobenzimide), a member of the 

urea-derivative chemical family, is an insecticide/acaricide (insect growth regulator) that behaves 

as a chitin inhibitor to suppress the growth of many leaf-eating larvae, mosquito larvae, aquatic 

midges, rust mite, boll weevil, and flies. 

Residues of Concern

The qualitative nature of the residue in plants and fungi is adequately understood based on data 

from citrus, mushroom, rice, and soybean metabolism studies. The metabolism of diflubenzuron 

in crops tested is similar, and the radioactive components are also similar to those found in soil. 

The nature of the residue in livestock is also adequately understood based on acceptable poultry 

and ruminant metabolism studies reflecting oral dosing. The HED Metabolism Assessment 

Review Committee (MARC) has concluded that the residues of concern, for the purpose of 

tolerance expression, are diflubenzuron and its metabolites 4-chlorophenylurea (CPU) and 4-

chloroaniline (PCA).
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

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Tolerances

Tolerances for residues of diflubenzuron are established under 40CFR §180.377. Tolerances 

listed in 40 CFR §180.377(a)(1) are expressed in terms of diflubenzuron per se. Under this 

section, current tolerances range from 0.05 ppm in/on eggs; milk; fat and meat of cattle, goat, 

hog, horse, poultry, and sheep; poultry meat byproducts to 6.0 ppm in globe artichoke.

Tolerances listed in 40 CFR §180.377(a)(2) are expressed in terms of the combined residues of 

diflubenzuron and its metabolites 4-chlorophenylurea (CPU) and 4-chloroaniline (PCA). Under 

this section, current tolerances range from 0.02 ppm in/on rice grain to 55 ppm in peanut hay.

Time-limited tolerances listed in 40 CFR §180.377(b) are expressed in terms of the combined 

residues of diflubenzuron and its metabolites CPU and PCA, expressed as the parent 

diflubenzuron, in connection with use of the pesticide under Section 18 Emergency Exemptions 

granted by EPA. Under this section, current tolerances range from 0.10 ppm in/on wheat milled 

byproducts to 30 ppm in/on wheat aspirated grain fractions.

Residue Data Used for Chronic Assessments

The current dietary exposure analyses assumed that diflubenzuron residues were present in all 

commodities at established/recommended tolerance levels for most commodities except orange 

(0.367 ppm), grapefruit (0.214 ppm) and lemon (0.653 ppm) which used average field trial 

residues. The chronic dietary exposure analysis assumed 100% of all proposed and existing

crops were treated, and that DEEMTM Version 7.81 default processing factors were used for some 

processed commodities. A processing factor of 0.1x was used for citrus juices. 

As part of the current petition, HED recommends establishing a crop group tolerance listed in 

Table 1 for residues of diflubenzuron. 

Table 1. Proposed/Recommended Tolerances for Diflubenzuron

Commodity Recommended Tolerance

Citrus fruit 10-10 3.0 ppm

Also, due to the nature of the plant, residential plantings of avocados are too prolific for 

stripping. A residue value of 0.8 ppm will be applied in this assessment for avocados for those 

potential residues. 

A residue value of 0.003 ppm was used for the PCA cancer assessment for all food commodities 

in DEEM. This represents 1⁄2 the LOQ. An average residue of 0.048 ppm was used for 

mushroom residue input value in the PCA cancer assessment. A residue value of 0.003 ppm was 

used for the CPU cancer assessment for milk commodities.
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

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III. Percent Crop Treated Information

The chronic non-cancer dietary exposure analysis used 100% crop treated while the cancer 

dietary exposure analysis used the following average percent crop treated: soybeans (1%), 

peppers (1%), oranges (5%), tangerines (5%), grapefruit (15%), pear (5%), apricot (10%), peach 

(5%), almond, (10%), pecan (2.5%), rice (1%), wheat (1%), cotton (1%), artichoke (50%), and 

peanut (5%) .

IV. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division, summarized in the following memorandum: 

“Ecological Risk and Drinking Water Assessments for Proposed Label Amendments of 

Diflubenzuron.” (DP #: 400093, F. Khan and S. Wente, 11/20/2012) and incorporated directly 

into this dietary assessment. Water residues were incorporated in the DEEM-FCID into the food 

categories “water, direct, all sources” and “water, indirect, all sources.” 

The estimated drinking water concentrations (EDWCs) for diflubenzuron use on citrus are higher 

than the previously recommended annual mean (chronic/non cancer) and 30 year average 

(chronic/cancer) concentrations for surface water. Therefore, the currently calculated EDWCs 

(3.47μg /L for the peak (acute) concentration, 0.26 μg /L for the annual mean (chronic/non 

cancer) concentration, and 0.12 μg /L for the 30 year average concentration (chronic/cancer) are 

recommended for diflubenzuron. 

The current EDWCs of 4-chlorophenyl urea (CPU) for surface water do not supersede the 

drinking water concentrations previously estimated (US EPA, 2002: D279732) for drinking 

water. Therefore, the values (20.68 μg/L for the peak (acute) concentration, 12.52 μg /L for the 

annual mean (chronic/non-cancer) concentration, and 8. 81 μg /L for the 36 year average 

concentration (chronic/cancer) from the previous drinking water assessment are recommended.

Since requested label modifications have no implication in groundwater modeling, 

groundwater exposure for drinking water was not performed. The previous SCI-GROW model 

estimated the concentrations of parent diflubenzuron and the degradate CPU in drinking water 

from shallow ground water sources to be 0.006 μg /L and 0.201 μg /L, respectively (US EPA, 

2002). The above concentrations can be considered as both the acute and chronic value for the 

respective chemicals.
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

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Summary of Estimated Surface Water and Groundwater Concentrations for Diflubenzuron.

Scenario Surface Water Conc., ppb

a Groundwater Conc., ppb b

Acute 24.2 0.207

Chronic (non-cancer) 12.8 (parent 12.52 ppb+ CPU 0.26 

ppb summed)

0.207

Chronic (cancer) 8.81 CPU

a

From the Tier II PRZM-EXAMS - Index Reservoir model. 

b

From the SCI-GROW model.

V. DEEM-FCID Program and Consumption Information

A diflubenzuron chronic dietary exposure assessment was conducted using the Dietary Exposure 

Evaluation Model software with the Food Commodity Intake Database DEEM-FCIDTM, Version 

3.16, which incorporates consumption data from USDA’s National Health and Nutrition 

Examination Survey, What We Eat in America, (NHANES/WWEIA). This dietary survey was 

conducted from 2003 to 2008. The data are based on the reported consumption of more than 

20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) 

are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; 

baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption 

data are averaged for the entire U.S. population and within population subgroups, but for acute 

exposure assessment are retained as individual consumption events. Based on analysis of the 

2003-2008 WWEIA consumption data, which took into account dietary patterns and survey 

respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total average 

estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the 

cPAD. This procedure is performed for each population subgroup.

VI. Toxicological Information

HED evaluated the toxicology data base for diflubenzuron and selected the following doses and 

endpoints for the chronic dietary and drinking water risk assessment. 

The following is excerpted from the HED Metabolism Committee Meeting Memorandum of 

5/31/01 (D272976).
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

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“CPU is the major degradate found in water and is a significant metabolite in milk. CPU is 

structurally related to monuron (N,N-dimethyl-CPU), a compound producing tumors of the 

kidney and liver in male rats. Given that there is no accepted mechanism of carcinogenicity for 

monuron and that CPU is major metabolite of monuron in rats, there is still concern for the 

toxicity of CPU. Thus, a literature search was conducted for any toxicity studies for CPU. As 

no pertinent information was found (Personal Communication, Alberto Protzel, 5/8/01), risk 

from CPU will be assessed as follows: 1) for carcinogenic effects, a Q1* will be calculated for 

monuron and applied to CPU;

EFED has determined that PCA is only a minor metabolite of DFB in the environment (K. 

Costello, Personal Communication, 2/28/01). Drinking water will thus not be considered in the 

risk assessment for PCA.

In summary, Cancer risks for CPU and PCA will be assessed individually. The tolerance 

expression should include parent, PCA and CPU. Although CPU is not of concern for the 

endpoints currently regulated for DFB, it is a major metabolite in milk and the major degradate 

found in water, with potential toxicity concerns.”

Therefore, a cancer assessment for CPU milk and water was conducted using a Q* of 1.52 x 10-2.

In addition, a cancer assessment for PCA food only was conducted using a Q* of 1.12 x 10-1.
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

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Exposure

Scenario

Dose Used in Risk 

Assessment, UF 

FQPA SF and LOC 

for Risk Assessment

Study and Toxicological Effects

Acute Dietary

all populations

Not Applicable Not Applicable No appropriate endpoint attributable to single 

exposure was available in oral studies. Therefore, a 

risk assessment is not required.

Chronic Dietary

all populations

NOAEL= 2 mg/kg/day

UF = 100

Chronic RfD = 

0.02 mg/kg/day

FQPA SF = 1x

cPAD = 

chronic RfD

FQPA SF

= 0.02 mg/kg/day

Chronic Toxicity Study - Dog

LOAEL = 10 mg/kg/day based on 

methemoglobinemia and sulfhemoglobinemia

Cancer (oral, dermal, 

inhalation)

Diflubenzuron

Not Required

Not Applicable Acceptable oral rat and mouse carcinogenicity 

studies; no evidence of carcinogenic or mutagenic 

potential. “Group E” evidence of noncarcinogenicity for humans.

Cancer (oral, dermal, 

inhalation)

PCA “Group B2" 

probably human 

carcinogen

Q1

*

1.12 x 10-1

(mg/kg/day)-1

Not Applicable NTP Oral mouse study

Cancer (oral, dermal, 

inhalation)

CPU Q1

*

based on 

monuron a structural 

analog and the Q1

*

1.52 x 

10-2

Not Applicable NTP Oral rat study

1. UF = uncertainty factor, FQPA SF = FQPA safety factor, NOAEL = no observed adverse effect level, LOAEL = 

lowest observed adverse effect level, cPAD = chronic population adjusted dose, RfD = reference dose, MOE = 

margin of exposure, LOC = level of concern.

2. Conversion from mg/L to oral dose (mg/k/day)
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

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VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. 

population and various population subgroups. The results reported in Table 3 are for the general 

U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50-99 years. The results reported in Tables 4 and 5 are 

for the general U.S. Population.

For the general population, there were no appropriate toxicological effects attributable to a single 

exposure (dose); therefore, an acute dose and endpoint were not identified for this risk 

assessment. Diflubenzuron has been classified as having “evidence of non-carcinogenicity for 

humans”; therefore, quantification of human cancer risk is not required and a cancer dietary 

assessment was not performed.

Results of the Chronic Non-cancer Dietary Exposure Analysis

The chronic dietary exposure for food and surface water utilized 11% of the cPAD for the U.S. 

population. The chronic dietary exposure for the highest exposed population subgroup, children 

1-2 years old, was 38% of the cPAD.

Table 3. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Diflubenzuron

Population Subgroup

Acute Dietary

(95 Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population

No toxic effects 

attributable to a single 

(i.e., acute) exposure to 

diflubenzuron have been 

identified; therefore, an 

acute reference dose 

(RfD) has not been 

established for 

diflubenzuron and an 

acute dietary exposure 

assessment has not been 

conducted.

0.002139 11

Diflubenzuron is 

classified as “Group E,” 

evidence of noncarcinogenicity for 

humans, therefore, a 

dietary cancer assessment 

is not required.

All Infants (< 1 year old) 0.002615 13

Children 1-2 years old 0.007606 38

Children 3-5 years old 0.005678 28

Children 6-12 years old 0.003006 15

Youth 13-19 years old 0.001800 9.0

Adults 20-49 years old 0.001634 8.2

Adults 50-99 years old 0.001667 8.3

Females 13-49 years old 0.001615 8.1

*The values for the highest exposed population for each type of risk assessment should be bolded
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

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Results of the Chronic Cancer Dietary Exposure Analysis

For PCA, the cancer dietary exposure estimate for the U.S. population is 1 x 10-6. For CPU, the 

cancer dietary exposure estimate for the U.S. population is 3 x 10-6.

Table 4. Summary of Dietary (Milk and Drinking Water) Exposure and Risk for Metabolite CPU

Population Subgroup

Acute Dietary

(95 Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD

Dietary 

Exposure

(mg/kg/day)

% cPAD

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population NA NA 0.000204 3 x 10-6

Table 5. Summary of Dietary (Food Only) Exposure and Risk for Metabolite PCA

Population Subgroup

Acute Dietary

(95 Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD

Dietary 

Exposure

(mg/kg/day)

% cPAD

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population NA NA 0.000010 1 x 10-6

VIII. Characterization of Inputs/Outputs

The chronic non-cancer analysis is slightly refined dietary exposure assessment. Average field 

trial residues were used for orange, grapefruit, and lemon. Tolerance level residues were used for 

all remaining commodities. Further refinement to the analysis could be made through the use of 

anticipated residues, incorporation of percent crop treated information for diflubenzuron and/or 

monitoring data that better reflect residues at the time of consumption. The PCA chronic cancer 

analysis is moderately refined. Percent crop treated information was used in the chronic cancer 

dietary exposure analysis. Since most field trials showed non-detectable residues for PCA 1⁄2 

LOD was used for the residue input. For the CPU analysis, 1⁄2 LOD was also used for milk 

residues.
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

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IX. Conclusions

Chronic dietary exposure analyses were performed for the general U.S. population and various 

population subgroups. The chronic non-cancer risk estimates for the general U.S. population and 

all population subgroups are below HED’s level of concern. HED is confident that chronic 

dietary exposures to diflubenzuron are not underestimated. For PCA, the cancer dietary exposure 

estimate for the U.S. population is 1 x 10-6. For CPU, the cancer dietary exposure estimate for 

the U.S. population is 3 x 10-6.

X. List of Attachments

1. Chronic DEEM-FCID Residue Input File.

2. Results of Chronic DEEM-FCID Dietary Exposure Analysis.

3. Cancer CPU DEEM-FCID Residue Input File.

4. Cancer PCA DEEM-FCID Residue Input File.

5. Results of Cancer CPU DEEM-FCID Dietary Exposure Analysis 

6. Results of Cancer PCA DEEM-FCID Dietary Exposure Analysis 
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

Page 12 of 22

Attachment 1 Chronic DEEM-FCID Residue Input File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\108201 

Diflubenzuron\Citrus 2F8015\CHRONIC.R08

Chemical: Diflubenzuron

RfD(Chronic): .02 mg/kg bw/day NOEL(Chronic): 2 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 09-18-2013/14:24:40 Program ver. 3.16, 03-08-d

Comment: Section 18 request for use on wheat and barley. Chronic only. cRfD = cPAD.

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0502063000 5B Broccoli raab 9.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 9.000000 1.000 1.000 

0502117000 5B Collards 9.000000 1.000 1.000 

0502194000 5B Kale 9.000000 1.000 1.000 

0502229000 5B Mustard greens 9.000000 1.000 1.000 

0502318000 5B Rape greens 9.000000 1.000 1.000 

0502389000 5B Turnip, greens 9.000000 1.000 1.000 

0600347000 6 Soybean, seed 0.050000 1.000 1.000 6F1832

0600349000 6 Soybean, soy milk 0.050000 1.000 1.000 6F1832

0600349001 6 Soybean, soy milk-babyfood or in 0.050000 1.000 1.000 6F1832

0600350000 6 Soybean, oil 0.050000 1.000 1.000 6F1832

0600350001 6 Soybean, oil-babyfood 0.050000 1.000 1.000 6F1832

0603348000 6C Soybean, flour 0.050000 1.000 1.000 6F1832

0603348001 6C Soybean, flour-babyfood 0.050000 1.000 1.000 6F1832

0802270000 8B Pepper, bell 1.000000 1.000 1.000 1F0623

 Full comment: 1F06235

0802270001 8B Pepper, bell-babyfood 1.000000 1.000 1.000 1F0623

 Full comment: 1F06235

0802271000 8B Pepper, bell, dried 1.000000 1.000 1.000 1F0623

 Full comment: 1F06235

0802271001 8B Pepper, bell, dried-babyfood 1.000000 1.000 1.000 1F0623

 Full comment: 1F06235

0802272000 8BC Pepper, nonbell 1.000000 1.000 1.000 1F0623

 Full comment: 1F06235

0802272001 8BC Pepper, nonbell-babyfood 1.000000 1.000 1.000 1F0623

 Full comment: 1F06235

0802273000 8BC Pepper, nonbell, dried 1.000000 1.000 1.000 1F0623

 Full comment: 1F06235

1001106000 10A Citron 3.000000 1.000 1.000 2F8015

1001107000 10A Citrus hybrids 3.000000 1.000 1.000 2F8015

1001108000 10A Citrus, oil 60.000000 1.000 1.000 2F8015

1001240000 10A Orange 0.367000 1.000 1.000 2F8015

1001241000 10A Orange, juice 0.367000 1.800 1.000 2F8015

1001241001 10A Orange, juice-babyfood 0.367000 1.800 1.000 2F8015

1001242000 10A Orange, peel 0.367000 1.000 1.000 2F8015

1001369000 10A Tangerine 3.000000 1.000 1.000 2F8015

1001370000 10A Tangerine, juice 3.000000 2.300 1.000 2F8015

1002197000 10B Kumquat 3.000000 1.000 1.000 2F8015

1002199000 10B Lemon 0.653000 1.000 1.000 2F8015

1002200000 10B Lemon, juice 0.653000 2.000 1.000 2F8015

1002200001 10B Lemon, juice-babyfood 0.653000 2.000 1.000 2F8015

1002201000 10B Lemon, peel 0.653000 1.000 1.000 2F8015

1002206000 10B Lime 3.000000 1.000 1.000 2F8015

1002207000 10B Lime, juice 3.000000 1.000 1.000 2F8015

1002207001 10B Lime, juice-babyfood 3.000000 1.000 1.000 2F8015

1003180000 10C Grapefruit 0.214000 1.000 1.000 2F8015

1003181000 10C Grapefruit, juice 0.214000 2.100 1.000 2F8015

1003307000 10C Pummelo 3.000000 1.000 1.000 2F8015

1100266000 11 Pear 0.500000 1.000 1.000 99OR00

 Full comment: 99OR0009

1100266001 11 Pear-babyfood 0.500000 1.000 1.000 99OR00

 Full comment: 99OR0009

1100267000 11 Pear, dried 0.500000 6.250 1.000 99OR00

 Full comment: 99OR0009

1100268000 11 Pear, juice 0.500000 1.000 1.000 99OR00

 Full comment: 99OR0009

1100268001 11 Pear, juice-babyfood 0.500000 1.000 1.000 99OR00

 Full comment: 99OR0009
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

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1202012000 12B Apricot 0.070000 1.000 1.000 1F0623

 Full comment: 1F06235

1202012001 12B Apricot-babyfood 0.070000 1.000 1.000 1F0623

 Full comment: 1F06235

1202013000 12B Apricot, dried 0.070000 6.000 1.000 1F0623

 Full comment: 1F06235

1202014000 12B Apricot, juice 0.070000 1.000 1.000 1F0623

 Full comment: 1F06235

1202014001 12B Apricot, juice-babyfood 0.070000 1.000 1.000 1F0623

 Full comment: 1F06235

1202230000 12B Nectarine 0.070000 1.000 1.000 1F0623

 Full comment: 1F06235

1202260000 12B Peach 0.070000 1.000 1.000 1F0623

 Full comment: 1F06235

1202260001 12B Peach-babyfood 0.070000 1.000 1.000 1F0623

 Full comment: 1F06235

1202261000 12B Peach, dried 0.070000 7.000 1.000 1F0623

 Full comment: 1F06235

1202261001 12B Peach, dried-babyfood 0.070000 7.000 1.000 1F0623

 Full comment: 1F06235

1202262000 12B Peach, juice 0.070000 1.000 1.000 1F0623

 Full comment: 1F06235

1202262001 12B Peach, juice-babyfood 0.070000 1.000 1.000 1F0623

 Full comment: 1F06235

1203285000 12C Plum 0.070000 1.000 1.000 1F0623

 Full comment: 1F06235

1203285001 12C Plum-babyfood 0.070000 1.000 1.000 1F0623

 Full comment: 1F06235

1203286000 12C Plum, prune, fresh 0.070000 1.000 1.000 1F0623

 Full comment: 1F06235

1203286001 12C Plum, prune, fresh-babyfood 0.070000 1.000 1.000 1F0623

 Full comment: 1F06235

1203287000 12C Plum, prune, dried 0.070000 5.000 1.000 1F0623

 Full comment: 1F06235

1203287001 12C Plum, prune, dried-babyfood 0.070000 5.000 1.000 1F0623

 Full comment: 1F06235

1203288000 12C Plum, prune, juice 0.070000 1.400 1.000 1F0623

 Full comment: 1F06235

1203288001 12C Plum, prune, juice-babyfood 0.070000 1.400 1.000 1F0623

 Full comment: 1F06235

1400003000 14 Almond 0.060000 1.000 1.000 0F0623

 Full comment: 0F06235

1400003001 14 Almond-babyfood 0.060000 1.000 1.000 0F0623

 Full comment: 0F06235

1400004000 14 Almond, oil 0.060000 1.000 1.000 0F0623

 Full comment: 0F06235

1400004001 14 Almond, oil-babyfood 0.060000 1.000 1.000 0F0623

 Full comment: 0F06235

1400059000 14 Brazil nut 0.060000 1.000 1.000 0F0623

 Full comment: 0F06235

1400068000 14 Butternut 0.060000 1.000 1.000 0F0623

 Full comment: 0F06235

1400081000 14 Cashew 0.060000 1.000 1.000 0F0623

 Full comment: 0F06235

1400092000 14 Chestnut 0.060000 1.000 1.000 0F0623

 Full comment: 0F06235

1400155000 14 Hazelnut 0.060000 1.000 1.000 0F0623

 Full comment: 0F06235

1400156000 14 Hazelnut, oil 0.060000 1.000 1.000 0F0623

 Full comment: 0F06235

1400185000 14 Hickory nut 0.060000 1.000 1.000 0F0623

 Full comment: 0F06235

1400213000 14 Macadamia nut 0.060000 1.000 1.000 0F0623

 Full comment: 0F06235

1400269000 14 Pecan 0.060000 1.000 1.000 0F0623

 Full comment: 0F06235

1400278000 14 Pine nut 0.060000 1.000 1.000 

1400282000 14 Pistachio 0.060000 1.000 1.000 0F0623

 Full comment: 0F06235

1400391000 14 Walnut 0.060000 1.000 1.000 8E3582

1500025000 15 Barley, pearled barley 0.060000 1.000 1.000 
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

Page 14 of 22

1500025001 15 Barley, pearled barley-babyfood 0.060000 1.000 1.000 

1500026000 15 Barley, flour 0.060000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 0.060000 1.000 1.000 

1500027000 15 Barley, bran 0.060000 1.000 1.000 

1500231000 15 Oat, bran 0.060000 1.000 1.000 

1500232000 15 Oat, flour 0.060000 1.000 1.000 

1500232001 15 Oat, flour-babyfood 0.060000 1.000 1.000 

1500233000 15 Oat, groats/rolled oats 0.060000 1.000 1.000 

1500233001 15 Oat, groats/rolled oats-babyfood 0.060000 1.000 1.000 

1500323000 15 Rice, white 0.020000 1.000 1.000 

1500323001 15 Rice, white-babyfood 0.020000 1.000 1.000 

1500324000 15 Rice, brown 0.020000 1.000 1.000 

1500324001 15 Rice, brown-babyfood 0.020000 1.000 1.000 

1500325000 15 Rice, flour 0.020000 1.000 1.000 

1500325001 15 Rice, flour-babyfood 0.020000 1.000 1.000 

1500326000 15 Rice, bran 0.020000 1.000 1.000 

1500326001 15 Rice, bran-babyfood 0.020000 1.000 1.000 

1500401000 15 Wheat, grain 0.060000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.060000 1.000 1.000 

1500402000 15 Wheat, flour 0.060000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.060000 1.000 1.000 

1500403000 15 Wheat, germ 0.060000 1.000 1.000 

1500404000 15 Wheat, bran 0.060000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.200000 1.000 1.000 7F1898

2003128001 20C Cottonseed, oil-babyfood 0.200000 1.000 1.000 7F1898

2100228000 21 Mushroom 0.200000 1.000 1.000 2E2731

3100044000 31 Beef, meat 0.050000 1.000 1.000 7F1898

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.000 7F1898

3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 7F1898

3100046000 31 Beef, meat byproducts 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235

3100046001 31 Beef, meat byproducts-babyfood 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235

3100047000 31 Beef, fat 0.050000 1.000 1.000 7F1898

3100047001 31 Beef, fat-babyfood 0.050000 1.000 1.000 7F1898

3100048000 31 Beef, kidney 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235

3100049000 31 Beef, liver 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235

3100049001 31 Beef, liver-babyfood 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235

3200169000 32 Goat, meat 0.050000 1.000 1.000 7F1898

3200170000 32 Goat, meat byproducts 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235

3200171000 32 Goat, fat 0.050000 1.000 1.000 7F1898

3200172000 32 Goat, kidney 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235

3200173000 32 Goat, liver 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235

3300189000 33 Horse, meat 0.050000 1.000 1.000 7F1898

3400290000 34 Pork, meat 0.050000 1.000 1.000 7F1898

3400290001 34 Pork, meat-babyfood 0.050000 1.000 1.000 7F1898

3400291000 34 Pork, skin 0.050000 1.000 1.000 7F1898

3400292000 34 Pork, meat byproducts 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235

3400292001 34 Pork, meat byproducts-babyfood 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235

3400293000 34 Pork, fat 0.050000 1.000 1.000 7F1898

3400293001 34 Pork, fat-babyfood 0.050000 1.000 1.000 7F1898

3400294000 34 Pork, kidney 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235

3400295000 34 Pork, liver 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235

3500339000 35 Sheep, meat 0.050000 1.000 1.000 7F1898

3500339001 35 Sheep, meat-babyfood 0.050000 1.000 1.000 7F1898

3500340000 35 Sheep, meat byproducts 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235

3500341000 35 Sheep, fat 0.050000 1.000 1.000 7F1898

3500341001 35 Sheep, fat-babyfood 0.050000 1.000 1.000 7F1898

3500342000 35 Sheep, kidney 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

Page 15 of 22

3500343000 35 Sheep, liver 0.150000 1.000 1.000 1F0623

 Full comment: 1F06235

3600222000 36 Milk, fat 0.050000 1.000 1.000 7F1898

3600222001 36 Milk, fat-baby food/infant formu 0.050000 1.000 1.000 7F1898

3600223000 36 Milk, nonfat solids 0.050000 1.000 1.000 7F1898

3600223001 36 Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 7F1898

3600224000 36 Milk, water 0.050000 1.000 1.000 7F1898

3600224001 36 Milk, water-babyfood/infant form 0.050000 1.000 1.000 7F1898

3600225001 36 Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000 7F1898

3800221000 38 Meat, game 0.050000 1.000 1.000 

3900312000 39 Rabbit, meat 0.050000 1.000 1.000 

4000093000 40 Chicken, meat 0.050000 1.000 1.000 7F1898

4000093001 40 Chicken, meat-babyfood 0.050000 1.000 1.000 7F1898

4000094000 40 Chicken, liver 0.050000 1.000 1.000 7F1898

4000095000 40 Chicken, meat byproducts 0.050000 1.000 1.000 7F1898

4000095001 40 Chicken, meat byproducts-babyfoo 0.050000 1.000 1.000 7F1898

4000096000 40 Chicken, fat 0.050000 1.000 1.000 7F1898

4000096001 40 Chicken, fat-babyfood 0.050000 1.000 1.000 7F1898

4000097000 40 Chicken, skin 0.050000 1.000 1.000 7F1898

4000097001 40 Chicken, skin-babyfood 0.050000 1.000 1.000 7F1898

5000382000 50 Turkey, meat 0.050000 1.000 1.000 7F1898

5000382001 50 Turkey, meat-babyfood 0.050000 1.000 1.000 7F1898

5000383000 50 Turkey, liver 0.050000 1.000 1.000 7F1898

5000383001 50 Turkey, liver-babyfood 0.050000 1.000 1.000 7F1898

5000384000 50 Turkey, meat byproducts 0.050000 1.000 1.000 7F1898

5000384001 50 Turkey, meat byproducts-babyfood 0.050000 1.000 1.000 7F1898

5000385000 50 Turkey, fat 0.050000 1.000 1.000 7F1898

5000385001 50 Turkey, fat-babyfood 0.050000 1.000 1.000 7F1898

5000386000 50 Turkey, skin 0.050000 1.000 1.000 7F1898

5000386001 50 Turkey, skin-babyfood 0.050000 1.000 1.000 7F1898

6000301000 60 Poultry, other, meat 0.050000 1.000 1.000 7F1898

6000302000 60 Poultry, other, liver 0.050000 1.000 1.000 7F1898

6000303000 60 Poultry, other, meat byproducts 0.050000 1.000 1.000 7F1898

6000304000 60 Poultry, other, fat 0.050000 1.000 1.000 7F1898

6000305000 60 Poultry, other, skin 0.050000 1.000 1.000 7F1898

7000145000 70 Egg, whole 0.050000 1.000 1.000 7F1898

7000145001 70 Egg, whole-babyfood 0.050000 1.000 1.000 7F1898

7000146000 70 Egg, white 0.050000 1.000 1.000 7F1898

7000146001 70 Egg, white (solids)-babyfood 0.050000 1.000 1.000 7F1898

7000147000 70 Egg, yolk 0.050000 1.000 1.000 7F1898

7000147001 70 Egg, yolk-babyfood 0.050000 1.000 1.000 7F1898

8601000000 86A Water, direct, all sources 0.012800 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.012800 1.000 1.000 

9500016000 O Artichoke, globe 6.000000 1.000 1.000 0E3835

9500263000 O Peanut 0.100000 1.000 1.000 

9500264000 O Peanut, butter 0.100000 1.890 1.000 

9500265000 O Peanut, oil 0.200000 1.000 1.000 
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

Page 16 of 22

Attachment 2 Results of Chronic DEEM-FCID Dietary Exposure Analysis

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for DIFLUBENZURON NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\108201 

Diflubenzuron\Citrus 2F8015\CHRONIC.R08

 Adjustment factor #2 used.

Analysis Date 09-19-2013/07:43:53 Residue file dated: 09-19-2013/07:42:46

Reference dose (RfD, Chronic) = .02 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.002139 10.7%

Hispanic 0.002629 13.1%

Non-Hisp-White 0.001891 9.5%

Non-Hisp-Black 0.002829 14.1%

Non-Hisp-Other 0.002534 12.7%

Nursing Infants 0.001233 6.2%

Non-Nursing Infants 0.003232 16.2%

Female 13+ PREG 0.002396 12.0%

Children 1-6 0.006149 30.7%

Children 7-12 0.002761 13.8%

Male 13-19 0.001971 9.9%

Female 13-19/NP 0.001637 8.2%

Male 20+ 0.001651 8.3%

Female 20+/NP 0.001618 8.1%

Seniors 55+ 0.001633 8.2%

All Infants 0.002615 13.1%

Female 13-50 0.001628 8.1%

Children 1-2 0.007606 38.0%

Children 3-5 0.005678 28.4%

Children 6-12 0.003006 15.0%

Youth 13-19 0.001800 9.0%

Adults 20-49 0.001634 8.2%

Adults 50-99 0.001667 8.3%

Female 13-49 0.001615 8.1%

-------------------------------------------------------------------------------
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

Page 17 of 22

Attachment 3 Cancer DEEM-FCID Residue Input File For CPU

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\108201 

Diflubenzuron\Citrus 2F8015\CPU Cancer Milk And Water.R08

Chemical: Diflubenzuron

RfD(Chronic): .02 mg/kg bw/day NOEL(Chronic): 2 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0152

Date created/last modified: 09-17-2013/12:25:46 Program ver. 3.16, 03-08-d

Comment: CPU Q*

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

3600222000 36 Milk, fat 0.003000 1.000 1.000 7F1898

3600222001 36 Milk, fat-baby food/infant formu 0.003000 1.000 1.000 7F1898

3600223000 36 Milk, nonfat solids 0.003000 1.000 1.000 7F1898

3600223001 36 Milk, nonfat solids-baby food/in 0.003000 1.000 1.000 7F1898

3600224000 36 Milk, water 0.003000 1.000 1.000 7F1898

3600224001 36 Milk, water-babyfood/infant form 0.003000 1.000 1.000 7F1898

3600225001 36 Milk, sugar (lactose)-baby food/ 0.003000 1.000 1.000 7F1898

8601000000 86A Water, direct, all sources 0.008810 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.008810 1.000 1.000 
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

Page 18 of 22

Attachment 4 Cancer DEEM-FCID Residue Input File For PCA

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\108201 

Diflubenzuron\Citrus 2F8015\PCA Cancer Food half loq 11-19.R08

Chemical: Diflubenzuron

RfD(Chronic): .02 mg/kg bw/day NOEL(Chronic): 2 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .112

Date created/last modified: 09-13-2013/19:35:56 Program ver. 3.16, 03-08-d

Comment: PCA Q*

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0502063000 5B Broccoli raab 0.003000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 0.003000 1.000 1.000 

0502117000 5B Collards 0.003000 1.000 1.000 

0502194000 5B Kale 0.003000 1.000 1.000 

0502229000 5B Mustard greens 0.003000 1.000 1.000 

0502318000 5B Rape greens 0.003000 1.000 1.000 

0502389000 5B Turnip, greens 0.003000 1.000 1.000 

0600347000 6 Soybean, seed 0.003000 1.000 0.010 

0600349000 6 Soybean, soy milk 0.003000 1.000 0.010 

0600349001 6 Soybean, soy milk-babyfood or in 0.003000 1.000 0.010 

0600350000 6 Soybean, oil 0.003000 1.000 0.010 

0600350001 6 Soybean, oil-babyfood 0.003000 1.000 0.010 

0603348000 6C Soybean, flour 0.003000 1.000 0.010 

0603348001 6C Soybean, flour-babyfood 0.003000 1.000 0.010 

0802270000 8B Pepper, bell 0.003000 1.000 0.010 

0802270001 8B Pepper, bell-babyfood 0.003000 1.000 0.010 

0802271000 8B Pepper, bell, dried 0.003000 1.000 0.010 

0802271001 8B Pepper, bell, dried-babyfood 0.003000 1.000 0.010 

0802272000 8BC Pepper, nonbell 0.003000 1.000 0.010 

0802272001 8BC Pepper, nonbell-babyfood 0.003000 1.000 0.010 

0802273000 8BC Pepper, nonbell, dried 0.003000 1.000 0.010 

1001106000 10A Citron 0.003000 1.000 1.000 2F8015

1001107000 10A Citrus hybrids 0.003000 1.000 1.000 2F8015

1001108000 10A Citrus, oil 0.003000 1.000 1.000 2F8015

1001240000 10A Orange 0.003000 1.000 0.050 

1001241000 10A Orange, juice 0.003000 0.100 0.050 

1001241001 10A Orange, juice-babyfood 0.003000 0.100 0.050 

1001242000 10A Orange, peel 0.003000 1.000 0.050 

1001369000 10A Tangerine 0.003000 1.000 0.050 

1001370000 10A Tangerine, juice 0.003000 0.100 0.050 

1002197000 10B Kumquat 0.003000 1.000 1.000 2F8015

1002199000 10B Lemon 0.003000 1.000 1.000 

1002200000 10B Lemon, juice 0.003000 0.100 1.000 

1002200001 10B Lemon, juice-babyfood 0.003000 0.100 1.000 

1002201000 10B Lemon, peel 0.003000 1.000 1.000 

1002206000 10B Lime 0.003000 1.000 1.000 2F8015

1002207000 10B Lime, juice 0.003000 0.100 1.000 2F8015

1002207001 10B Lime, juice-babyfood 0.003000 0.100 1.000 2F8015

1003180000 10C Grapefruit 0.003000 1.000 0.150 

1003181000 10C Grapefruit, juice 0.003000 0.100 0.150 

1003307000 10C Pummelo 0.003000 1.000 1.000 2F8015

1100266000 11 Pear 0.003000 1.000 0.050 

1100266001 11 Pear-babyfood 0.003000 1.000 0.050 

1100267000 11 Pear, dried 0.003000 6.250 0.050 

1100268000 11 Pear, juice 0.003000 1.000 0.050 

1100268001 11 Pear, juice-babyfood 0.003000 1.000 0.050 

1202012000 12B Apricot 0.003000 1.000 0.100 

1202012001 12B Apricot-babyfood 0.003000 1.000 0.100 

1202013000 12B Apricot, dried 0.003000 6.000 0.100 

1202014000 12B Apricot, juice 0.003000 1.000 0.100 

1202014001 12B Apricot, juice-babyfood 0.003000 1.000 0.100 

1202230000 12B Nectarine 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

1202260000 12B Peach 0.003000 1.000 0.050 

1202260001 12B Peach-babyfood 0.003000 1.000 0.050 

1202261000 12B Peach, dried 0.003000 7.000 0.050 

1202261001 12B Peach, dried-babyfood 0.003000 7.000 0.050 

1202262000 12B Peach, juice 0.003000 1.000 0.050 
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

Page 19 of 22

1202262001 12B Peach, juice-babyfood 0.003000 1.000 0.050 

1203285000 12C Plum 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

1203285001 12C Plum-babyfood 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

1203286000 12C Plum, prune, fresh 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

1203286001 12C Plum, prune, fresh-babyfood 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

1203287000 12C Plum, prune, dried 0.003000 5.000 1.000 1F0623

 Full comment: 1F06235

1203287001 12C Plum, prune, dried-babyfood 0.003000 5.000 1.000 1F0623

 Full comment: 1F06235

1203288000 12C Plum, prune, juice 0.003000 1.400 1.000 1F0623

 Full comment: 1F06235

1203288001 12C Plum, prune, juice-babyfood 0.003000 1.400 1.000 1F0623

 Full comment: 1F06235

1400003000 14 Almond 0.003000 1.000 0.100 

1400003001 14 Almond-babyfood 0.003000 1.000 0.100 

1400004000 14 Almond, oil 0.003000 1.000 0.100 

1400004001 14 Almond, oil-babyfood 0.003000 1.000 0.100 

1400059000 14 Brazil nut 0.003000 1.000 1.000 0F0623

 Full comment: 0F06235

1400068000 14 Butternut 0.003000 1.000 1.000 0F0623

 Full comment: 0F06235

1400081000 14 Cashew 0.003000 1.000 1.000 0F0623

 Full comment: 0F06235

1400092000 14 Chestnut 0.003000 1.000 1.000 0F0623

 Full comment: 0F06235

1400155000 14 Hazelnut 0.003000 1.000 1.000 0F0623

 Full comment: 0F06235

1400156000 14 Hazelnut, oil 0.003000 1.000 1.000 0F0623

 Full comment: 0F06235

1400185000 14 Hickory nut 0.003000 1.000 1.000 0F0623

 Full comment: 0F06235

1400213000 14 Macadamia nut 0.003000 1.000 1.000 0F0623

 Full comment: 0F06235

1400269000 14 Pecan 0.003000 1.000 0.025 

1400278000 14 Pine nut 0.003000 1.000 1.000 

1400282000 14 Pistachio 0.003000 1.000 1.000 0F0623

 Full comment: 0F06235

1400391000 14 Walnut 0.003000 1.000 1.000 8E3582

1500025000 15 Barley, pearled barley 0.003000 1.000 1.000 

1500025001 15 Barley, pearled barley-babyfood 0.003000 1.000 1.000 

1500026000 15 Barley, flour 0.003000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 0.003000 1.000 1.000 

1500027000 15 Barley, bran 0.003000 1.000 1.000 

1500231000 15 Oat, bran 0.003000 1.000 1.000 

1500232000 15 Oat, flour 0.003000 1.000 1.000 

1500232001 15 Oat, flour-babyfood 0.003000 1.000 1.000 

1500233000 15 Oat, groats/rolled oats 0.003000 1.000 1.000 

1500233001 15 Oat, groats/rolled oats-babyfood 0.003000 1.000 1.000 

1500323000 15 Rice, white 0.003000 1.000 0.010 

1500323001 15 Rice, white-babyfood 0.003000 1.000 0.010 

1500324000 15 Rice, brown 0.003000 1.000 0.010 

1500324001 15 Rice, brown-babyfood 0.003000 1.000 0.010 

1500325000 15 Rice, flour 0.003000 1.000 0.010 

1500325001 15 Rice, flour-babyfood 0.003000 1.000 0.010 

1500326000 15 Rice, bran 0.003000 1.000 0.010 

1500326001 15 Rice, bran-babyfood 0.003000 1.000 0.010 

1500401000 15 Wheat, grain 0.003000 1.000 0.010 

1500401001 15 Wheat, grain-babyfood 0.003000 1.000 0.010 

1500402000 15 Wheat, flour 0.003000 1.000 0.010 

1500402001 15 Wheat, flour-babyfood 0.003000 1.000 0.010 

1500403000 15 Wheat, germ 0.003000 1.000 0.010 

1500404000 15 Wheat, bran 0.003000 1.000 0.010 

2003128000 20C Cottonseed, oil 0.003000 1.000 0.010 

2003128001 20C Cottonseed, oil-babyfood 0.003000 1.000 0.010 

2100228000 21 Mushroom 0.048000 1.000 1.000 2E2731

3100044000 31 Beef, meat 0.003000 1.000 1.000 7F1898

3100044001 31 Beef, meat-babyfood 0.003000 1.000 1.000 7F1898
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

Page 20 of 22

3100045000 31 Beef, meat, dried 0.003000 1.920 1.000 7F1898

3100046000 31 Beef, meat byproducts 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3100046001 31 Beef, meat byproducts-babyfood 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3100047000 31 Beef, fat 0.003000 1.000 1.000 7F1898

3100047001 31 Beef, fat-babyfood 0.003000 1.000 1.000 7F1898

3100048000 31 Beef, kidney 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3100049000 31 Beef, liver 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3100049001 31 Beef, liver-babyfood 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3200169000 32 Goat, meat 0.003000 1.000 1.000 7F1898

3200170000 32 Goat, meat byproducts 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3200171000 32 Goat, fat 0.003000 1.000 1.000 7F1898

3200172000 32 Goat, kidney 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3200173000 32 Goat, liver 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3300189000 33 Horse, meat 0.003000 1.000 1.000 7F1898

3400290000 34 Pork, meat 0.003000 1.000 1.000 7F1898

3400290001 34 Pork, meat-babyfood 0.003000 1.000 1.000 7F1898

3400291000 34 Pork, skin 0.003000 1.000 1.000 7F1898

3400292000 34 Pork, meat byproducts 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3400292001 34 Pork, meat byproducts-babyfood 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3400293000 34 Pork, fat 0.003000 1.000 1.000 7F1898

3400293001 34 Pork, fat-babyfood 0.003000 1.000 1.000 7F1898

3400294000 34 Pork, kidney 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3400295000 34 Pork, liver 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3500339000 35 Sheep, meat 0.003000 1.000 1.000 7F1898

3500339001 35 Sheep, meat-babyfood 0.003000 1.000 1.000 7F1898

3500340000 35 Sheep, meat byproducts 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3500341000 35 Sheep, fat 0.003000 1.000 1.000 7F1898

3500341001 35 Sheep, fat-babyfood 0.003000 1.000 1.000 7F1898

3500342000 35 Sheep, kidney 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3500343000 35 Sheep, liver 0.003000 1.000 1.000 1F0623

 Full comment: 1F06235

3800221000 38 Meat, game 0.003000 1.000 1.000 

3900312000 39 Rabbit, meat 0.003000 1.000 1.000 

4000093000 40 Chicken, meat 0.003000 1.000 1.000 7F1898

4000093001 40 Chicken, meat-babyfood 0.003000 1.000 1.000 7F1898

4000094000 40 Chicken, liver 0.003000 1.000 1.000 7F1898

4000095000 40 Chicken, meat byproducts 0.003000 1.000 1.000 7F1898

4000095001 40 Chicken, meat byproducts-babyfoo 0.003000 1.000 1.000 7F1898

4000096000 40 Chicken, fat 0.003000 1.000 1.000 7F1898

4000096001 40 Chicken, fat-babyfood 0.003000 1.000 1.000 7F1898

4000097000 40 Chicken, skin 0.003000 1.000 1.000 7F1898

4000097001 40 Chicken, skin-babyfood 0.003000 1.000 1.000 7F1898

5000382000 50 Turkey, meat 0.003000 1.000 1.000 7F1898

5000382001 50 Turkey, meat-babyfood 0.003000 1.000 1.000 7F1898

5000383000 50 Turkey, liver 0.003000 1.000 1.000 7F1898

5000383001 50 Turkey, liver-babyfood 0.003000 1.000 1.000 7F1898

5000384000 50 Turkey, meat byproducts 0.003000 1.000 1.000 7F1898

5000384001 50 Turkey, meat byproducts-babyfood 0.003000 1.000 1.000 7F1898

5000385000 50 Turkey, fat 0.003000 1.000 1.000 7F1898

5000385001 50 Turkey, fat-babyfood 0.003000 1.000 1.000 7F1898

5000386000 50 Turkey, skin 0.003000 1.000 1.000 7F1898

5000386001 50 Turkey, skin-babyfood 0.003000 1.000 1.000 7F1898

6000301000 60 Poultry, other, meat 0.003000 1.000 1.000 7F1898

6000302000 60 Poultry, other, liver 0.003000 1.000 1.000 7F1898

6000303000 60 Poultry, other, meat byproducts 0.003000 1.000 1.000 7F1898

6000304000 60 Poultry, other, fat 0.003000 1.000 1.000 7F1898

6000305000 60 Poultry, other, skin 0.003000 1.000 1.000 7F1898
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

Page 21 of 22

7000145000 70 Egg, whole 0.003000 1.000 1.000 7F1898

7000145001 70 Egg, whole-babyfood 0.003000 1.000 1.000 7F1898

7000146000 70 Egg, white 0.003000 1.000 1.000 7F1898

7000146001 70 Egg, white (solids)-babyfood 0.003000 1.000 1.000 7F1898

7000147000 70 Egg, yolk 0.003000 1.000 1.000 7F1898

7000147001 70 Egg, yolk-babyfood 0.003000 1.000 1.000 7F1898

9500016000 O Artichoke, globe 0.003000 1.000 0.500 

9500263000 O Peanut 0.003000 1.000 0.050 

9500264000 O Peanut, butter 0.003000 1.890 0.050 

9500265000 O Peanut, oil 0.003000 1.000 0.050 
Diflubenzuron (PC Code 108201) Dietary Exposure and Risk Assessment DP #: 407784

Page 22 of 22

Attachment 5 Results of Cancer DEEM-FCID Dietary Exposure Analysis for CPU

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for DIFLUBENZURON NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\108201 

Diflubenzuron\Citrus 2F8015\CPU Cancer Milk And Water.R08

 Adjustment factor #2 used.

Analysis Date 09-17-2013/12:26:22 Residue file dated: 09-17-2013/12:25:46

Q* = 0.0152 

COMMENT 1: CPU Q*

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Lifetime risk

 Subgroup body wt/day (Q*= .0152)

-------------------------------------- ------------- --------------

Total US Population 0.000204 3.10E-06

Attachment 6 Results of Cancer DEEM-FCID Dietary Exposure Analysis for PCA

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for DIFLUBENZURON NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\108201 

Diflubenzuron\Citrus 2F8015\PCA Cancer Food half loq 11-19.R08

 Adjustment factor #2 used.

Analysis Date 11-19-2013/07:23:19 Residue file dated: 11-19-2013/07:21:48

Q* = 0.112 

COMMENT 1: PCA Q*

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Lifetime risk

 Subgroup body wt/day (Q*= .112)

-------------------------------------- ------------- --------------

Total US Population 0.000010 1.09E-06