SAT Report

PMN Number: P-11-0528

SAT Date: 8/2/2011

Print Date: 5/1/2013

Related cases:

Health related cases: 

Ecotox related cases: 

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1-2 3 Health: PMN substance ; Eco: chronic concerns only for the intact materi

2 3 Health: Incomplete incineration product ; Eco: concern for toxicity of inco

incineration produts to terrestrial organisms

 Persistence Bioaccum Toxicity Comments

3 31

2

Exposure Based Review:

Health: No

Ecotox: No

Routes of exposure: Health: Dermal Drinking Water Inhalation 

Ecotox: All releases to water

Fate: ;

P2Rec Comments:

Comment: Noi Comment

Keywords:

 Keywords: 

IRR-E,S,L

GI

SENS

UNCERT DEVEL

AQUATOX-C

LIVER

BLOOD
MALE REPRO

IMMUNO

ONCO

AQUATOX-C

Summary of Assessment:

 Fate:

Fate Summary: P-11-0528

FATE: 

log Kow = 7.38 (E) 

VP = 5.7E-2 torr at 25 C (E)

BP = 236 C (E)

H = 9.74E+0 (E)

log Koc = 6.76 (E)

log Fish BCF = 3.94 (E)

log Fish BAF = 5.87 (E) 

POTW removal (%) = 50-90 via sorption and stripping

Time for complete ultimate aerobic biodeg > mo

Sorption to soils/sediments = moderate

Volatilization half-life from a standard river = 2 hrs

Volatilization half-life from a standard lake = 9 da

Atmospheric Oxidation Half-life = 2.0 hr via OH radical

PBT Potential: P3B3

*CEB FATE: Migration to ground water = moderate

 Health:

 Health Summary: Absorption is poor all routes, based on physical/chemical 

properties. The thiol constituent of the PMN can form in the body. There is concern 

for irritation to the eye, skin, and lung, and for disturbances to the GI tract if ingested, based on 

information in the PMN MSDS. There also is concern for sensitization, and uncertain concern 

for developmental toxicity, based on 

.

For the potential degradation product, based on test data for the analog 

concerns are liver toxicity, blood toxicity, and male reproductive toxicity [rat 28-day oral 

NOAEL = 50 mg/kg, LOAEL = 150 mg/kg with liver toxicity; rat 90-day oral LOAEL = 10 

mg/kg based on decreased body weight in males at all doses and liver toxicity and anemia at 200 

mg/kg; there were toxic effects on the testes in 2 males in the 90-day oral study that were judged 

by the reviewer to be indicative of the potential for male reproductive toxicity. There is also 

concern for immunosuppression and oncogenicity based on data for 
 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 *

daphnid 48-h LC50 *

green algal 96-h EC50 *

fish _ chronic value 0.001

daphnid _ chronic 

value

0.001

algal _ chronic 

value

0.016 or *

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for thiols; SAR chemical class = 

thiol- MW 468; log Kow = 7.38 (EPI), 6.71 (ACD); pH7; 

100% active ingredients and mean measured concentrations; hardness <180.0 mg/L as CaCO3; 

and TOC <2.0 mg/L;

high concern for the degradation product

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

1

SARs thiols

SAR Class thiol new chemicals category: thiols

Ecotox Category 

Ecotox Factors Comments: 

 SAT Chair: J. Kwiat