Form of Preferred Purchase Agreement



 Exhibit 4.9 

PREFERRED STOCK PURCHASE AGREEMENT 

This Preferred Stock Purchase Agreement (“Agreement”) is effective as of April     ,
2010 (“Effective Date”), by and among International Stem Cell Corporation, a Delaware corporation (“Company”), and
                             (including its designees, successors and assigns,
“Investor”). 
 RECITALS 

A. The parties desire that, upon the terms and subject to the conditions contained herein, the Company shall issue to Investor, and
Investor shall purchase from the Company, up to $10,000,000.00 of shares of Series F Preferred Stock. 
 B. The offer and sale
of the Securities provided for herein are being made pursuant to a registration statement filed under the Act. 
 AGREEMENT

 NOW, THEREFORE, IN CONSIDERATION of the premises, the mutual covenants and other provisions contained in this Agreement,
and for other good and valuable consideration the receipt and adequacy of which are hereby acknowledged, Company and Investor agree as follows: 

ARTICLE 1 

DEFINITIONS 

Definitions. In addition to the terms defined elsewhere in this Agreement: (a) capitalized terms that are not
otherwise defined herein have the meanings given to such terms in the Certificate of Designations, and (b) the following terms have the meanings indicated in this Article 1: 

“Act” means the Securities Act of 1933, as amended. 

“Affiliate” means any Person that, directly or indirectly through one or more intermediaries, controls, is controlled
by, or is under common control with a Person, as such terms are used in and construed under Rule 144 under the Act. With respect to Investor, without limitation, any Person owning, owned by, or under common ownership with Investor, and any
investment fund or managed account that is managed on a discretionary basis by the same investment manager as Investor will be deemed to be an Affiliate. 

“Agreement” means this Preferred Stock Purchase Agreement including the Exhibits and Schedules hereto. 

“Certificate of Designations” means the certificate to be filed with the Secretary of State of the State of Delaware, in
the form attached hereto as Exhibit B. 
  

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 “Change in Control” has the meaning set forth within the definition of
Strategic Transaction, below. 
 “Closing” means any one of (i) the Commitment Closing and (ii) the
Preferred Stock Closing. 
 “Commitment Closing” has the meaning set forth in Section 2.2(a).

 “Commitment Fee” means a non-refundable fee of $500,000.00 (5.0% of the Maximum Placement), payable by the
Company to Investor on the date the Registration Statement is declared effective, in shares of registered Common Stock valued at 90% of the volume-weighted average price for the Common Stock for the five trading days immediately preceding the
Commitment Closing or as otherwise set forth in Section 2.2(a). 
 “Common Shares” includes the Fee Shares
and any Warrant Shares. 
 “Common Stock” means the common stock, par value $0.001 per share, of Company, and
any replacement or substitute thereof, or any share capital into which such Common Stock shall have been changed or any share capital resulting from a reclassification of such Common Stock. 

“Company Termination” has the meaning set forth in Section 3.2. 

“Delisting Event” means any time during the term of this Agreement, that the Company’s Common Stock is not listed
for and actively trading on a Trading Market, or is suspended or delisted with respect to the trading of the shares of Common Stock on a Trading Market. 

“Disclosure Schedules” means the Disclosure Schedules of the Company delivered concurrently herewith and attached hereto
and incorporated herein by reference. 
 “DWAC Shares” means all Common Shares or other shares of Common Stock
issued or issuable to Investor or any Affiliate, successor or assign of Investor pursuant to any of the Transaction Documents, including without limitation any Warrant Shares, all of which shall be issued in electronic form, freely tradable and
without restriction on resale, and timely credited by Company to the specified Deposit/Withdrawal at Custodian (DWAC) account with Depository Trust Company (DTC) under its Fast Automated Securities Transfer (FAST) Program or any similar program
hereafter adopted by DTC performing substantially the same function, in accordance with irrevocable instructions issued to and countersigned by the Transfer Agent, substantially in the form attached hereto as Exhibit C. 

“Exchange Act” means the Securities Exchange Act of 1934, as amended. 

“Fee Shares” means any shares of Common Stock issued by the Company to Investor in payment of the Commitment Fee.

 “GAAP” means United States generally accepted accounting principles applied on a consistent basis during the
periods involved. 
  

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 “Indebtedness” means (a) any liabilities for borrowed money or amounts
owed in excess of $50,000 (other than trade accounts payable incurred in the ordinary course of business), (b) all guaranties, endorsements and other contingent obligations in respect of Indebtedness of others, whether or not the same are or
should be reflected in the Company’s balance sheet (or the notes thereto), except guaranties by endorsement of negotiable instruments for deposit or collection or similar transactions in the ordinary course of business; and (c) the present
value of any lease payments in excess of $50,000 due under leases required to be capitalized in accordance with GAAP. 

“Liens” means a lien, charge, security interest, encumbrance, right of first refusal, preemptive right or other
restriction. 
 “Lock-Up Agreements” means an agreement in the form attached as Exhibit D, executed by
each of the Company’s officers, directors and beneficial owners of 10% or more of the Common Stock, precluding each such Person from participating in any sale of the Common Stock from the Preferred Stock Notice Date through the Preferred Stock
Closing Date. 
 “Material Agreement” includes any loan agreement, equity investment agreement or securities
instrument to which Company is a party, any agreement or instrument to which Company and Investor or any Affiliate of Investor is a party, and any other material agreement listed, or required to be listed, on any of Company’s reports filed or
required to be filed with the SEC, including without limitation Forms 10-K, 10-Q or 8-K. 
 “Maximum Placement”
means $10,000,000.00. 
 “Officer’s Closing Certificate” means a certificate in customary form reasonably
acceptable to the Investor, executed by an authorized officer of the Company. 
 “Opinion” means an opinion
from Company’s independent legal counsel, in the form attached as Exhibit E, or such other form as agreed upon by the parties, to be delivered in connection with the Commitment Closing. 

“Person” means an individual or corporation, partnership, trust, incorporated or unincorporated association, joint
venture, limited liability company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind. 

“Preferred Shares” means shares of Series F Preferred Stock of the Company provided for in the Certificate of
Designations, to be issued to Investor pursuant to this Agreement. 
 “Preferred Stock Closing” has the meaning
set forth in Section 2.3(f). 
 “Preferred Stock Closing Date” has the meaning set forth in
Section 2.3(f). 
 “Preferred Stock Notice” has the meaning set forth in
Section 2.3(b). 
 “Preferred Stock Notice Date” has the meaning set forth in
Section 2.3(b). 
  

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 “Preferred Stock Purchase Price” has the meaning set forth in
Section 2.3(b) and shall be specified in writing by the Company. 
 “Preferred Stock Share Price”
means $10,000.00 per Preferred Share. The Company may not sell fractional Preferred Shares. 
 “Prospectus” has
the meaning set forth in Section 4.1(hh)(iii). 
 “Registration Statement” means a valid, current
and effective registration statement registering for sale the Preferred Shares, the Warrants and the Common Shares, and except where the context otherwise requires, means the registration statement, as amended, including (i) all documents filed
as a part thereof or incorporated by reference therein, and (ii) any information contained or incorporated by reference in a prospectus filed with the SEC in connection with such registration statement, to the extent such information is deemed
under the Act to be part of the registration statement. 
 “SEC” means the United States Securities and
Exchange Commission. 
 “Securities” includes the Warrants, the Fee Shares, Common Shares and Preferred Shares
issuable pursuant to this Agreement. 
 “Strategic Transaction” means and shall be deemed to have occurred at
such time upon any of the following events: 
 (i) a consolidation, merger or other business combination or event or
transaction following which the holders of Common Stock immediately preceding such consolidation, merger, combination or event either (i) no longer hold a majority of the shares of Common Stock or (ii) no longer have the ability to elect a
majority the board of directors of the Company (a “Change in Control”); 
 (ii) the sale or transfer of all or
substantially all of the Company’s assets, other than in the ordinary course of business; or 
 (iii) a purchase, tender
or exchange offer made to the holders of the outstanding shares of Common Stock. 
 “Subsidiary” means any
Person the Company owns or controls, or in which the Company, directly or indirectly, owns a majority of the capital stock or similar interest that would be disclosable pursuant to Regulation S-K, Item 601(b)(21). 

“Termination” has the meaning set forth in Section 3.1. 

“Termination Date” means the date that is fifty (50) calendar days after the Effective Date. 

“Termination Notice” has the meaning as set forth in Section 3.2. 

 

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 “Trading Day” means any day on which the Common Stock is traded on the
Trading Market; provided that it shall not include any day on which the Common Stock is (a) scheduled to trade for less than 5 hours, or (b) suspended from trading. 

“Trading Market” means the OTC Bulletin Board, the NASDAQ Capital Market, the NASDAQ Global Market, the NASDAQ Global
Select Market, the NYSE Amex, or the New York Stock Exchange, whichever is at the time the principal trading exchange or market for the Common Stock. 

“Transaction Documents” include this Agreement, the other agreements and documents referenced herein, and the Exhibits
and Schedules hereto and thereto. 
 “Transfer Agent” means Securities Transfer Corporation, or any successor
transfer agent for the Common Stock. 
 “Warrant Shares” means the shares of Common Stock issuable upon
exercise of the Warrants. 
 “Warrant” means the warrant issuable under this Agreement, in the form attached
hereto as Exhibit A, to purchase shares of Common Stock equal in value to 135% of the Maximum Placement ($13,500,000), subject to adjustment as set forth therein. 

ARTICLE 2 

PURCHASE AND SALE 

2.1 Agreement to Purchase. Subject to the terms and conditions herein and the satisfaction of the conditions to closing set
forth in this Article 2: 
 (a) Investor hereby agrees to purchase up to $10,000,000 of Preferred Shares as the
Company may, in its sole and absolute discretion, elect to issue and sell to Investor pursuant to Section 2.3 below; and 

(b) The Company agrees to issue Fee Shares and Warrants and Warrant Shares to Investor pursuant to Section 2.2(a) and
Section 2.3(c) below. 
 2.2 Investment Commitment. 

(a) Investment Commitment. 

(i) The closing of this Agreement (the “Commitment Closing”) shall be deemed to occur when this Agreement has
been duly executed by both Investor and the Company, and the other Conditions to the Commitment Closing set forth in Section 2.2(b) have been met. On the date of the Commitment Closing, the Company shall issue the Warrant to Investor.

 (ii) The Commitment Fee is payable by the Company to Investor in consideration of Investor’s commitment to fund
the investment contemplated by this Agreement. The Commitment Fee is earned in full on the Effective Date and shall be paid on the date the 

 

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Registration Statement is declared effective, in shares of registered Common Stock valued at 90% of the volume-weighted average price for the Common Stock for the five trading days immediately
preceding the Commitment Closing. Notwithstanding the foregoing, if for any reason whatsoever the Commitment Fee has not been paid in full by the six-month anniversary of the Effective Date, then it shall be paid by the Company on such date, in
cash, by wire transfer of immediately available funds to the account specified by Investor. 
 (b) Conditions to
Investment Commitment. As a condition precedent to the Commitment Closing, all of the following (the “Conditions to Commitment Closing”) shall have been satisfied prior to or concurrently with the Company’s execution and
delivery of this Agreement: 
 (i) the following documents shall have been delivered to Investor: (A) this
Agreement (including the Disclosure Schedules), executed by the Company, (B) a Secretary’s Certificate, attaching copies and certifying as to (x) the resolutions of the Company’s board of directors authorizing this Agreement and
the Transaction Documents, and the transactions contemplated hereby and thereby, (y) a copy of the Company’s current Certificate of Incorporation, and (z) a copy of the Company’s current Bylaws; (C) the Certificate of
Designations executed by the Company and filed by the Secretary of State of Delaware; (D) the Opinion, and (E) a copy of the press release announcing the transactions contemplated by this Agreement and a copy of the Current Report on Form
8-K to be filed with the SEC pursuant to Section 5.4 describing the transaction contemplated by this Agreement and attaching a complete copy of the Transaction Documents; 

(ii) other than for losses incurred in the ordinary course of business, there have been no material adverse changes in the
Company’s business prospects or financial condition since the date of the last balance sheet delivered to Investor, including but not limited to incurring material liabilities; 

(iii) the representations and warranties of the Company in this Agreement shall be true and correct in all material respects and
the Company shall have delivered an Officer’s Closing Certificate, signed by an officer of the Company, to such effect to Investor; and 

(iv) Investor shall have received the Warrant. 

(c) Investor’s Obligation to Purchase. Subject to the prior satisfaction of all conditions set forth in this
Agreement, following the Investor’s receipt of a validly delivered Preferred Stock Notice, the Investor shall be required to purchase from the Company the number of Preferred Shares, in the manner described in Section 2.3 below.

  

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 2.3 Preferred Share Sale to Investor. 

(a) Procedure. Subject to the other conditions and limitations set forth in this Agreement, at any time beginning on the
Effective Date, the Company may, in its sole and absolute discretion, elect to require Investor to purchase the Preferred Shares according to the following procedure: 

(b) Delivery of Preferred Stock Notice. The Company shall deliver an irrevocable written notice (the “Preferred
Stock Notice”), the form of which is attached hereto as Exhibit F, to Investor stating that the Company has exercised its rights and stating the Company will sell the Preferred Shares to Investor at the Preferred Stock Share Price,
and at the aggregate purchase equal to the Maximum Placement (the “Preferred Stock Purchase Price”). A Preferred Stock Notice delivered by the Company to Investor after 5:00 p.m. New York Time on any Trading Day via facsimile or
electronic mail, with confirming copy by overnight carrier, shall be deemed delivered on the next Trading Day (the “Preferred Stock Notice Date”). 

(c) Warrant. Prior to delivery of the Preferred Stock Notice, the Warrant shall have been delivered to Investor. On the
Preferred Stock Notice Date, the Warrant shall vest and become exercisable in full and may be exercised at any time on or after such Preferred Stock Notice Date. Any portion of the Warrant that is exercised by Investor in accordance with
Section 1.1 of the Warrant shall be deemed exercised (i) on the Preferred Stock Notice Date, if the Company receives the Exercise Delivery Documents from Investor by 6:30 p.m. Eastern time on the Preferred Stock Notice Date, or
(ii) on the next Trading Day, if the Company receives the Exercise Delivery Documents from Investor after 6:30 p.m. Eastern Time on the applicable Preferred Stock Notice Date or on any subsequent date. 

(d) Conditions Precedent to the Right of the Company to Deliver the Preferred Stock Notice. The right of the Company to
deliver the Preferred Stock Notice is subject to the satisfaction (or written waiver by Investor in its sole satisfaction), on the date of delivery of such Preferred Stock Notice, of each of the following conditions: 

(i) the Common Stock shall be listed on a Trading Market, and to the Company’s knowledge there is no notice of any
suspension or delisting with respect the trading of the shares of Common Stock on such market or exchange; 
 (ii) the
representations and warranties of the Company set forth in this Agreement are true and correct in all material respects as if made on such date (provided, however, that any information disclosed by the Company in a filing with the SEC prior to the
Preferred Stock Notice Date shall be deemed to update the Disclosure Schedules and modify the representations and warranties), and no default shall have occurred under this Agreement, or any other agreement with Investor, or with any Affiliate of
Investor, or any other financial agreement or agreement for borrowed funds of the Company, and the Company shall deliver an Officer’s Closing Certificate, signed by an officer of the Company, to such effect to Investor; 

(iii) other than for losses incurred in the ordinary course of business, there have been no material adverse changes in the
Company’s business prospects or financial condition since the Commitment Closing, including but not limited to incurring material liabilities; 

(iv) the Company is not, and will not be as a result of the contemplated sale of Preferred Stock, in default of any Material
Agreement; 
  

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 (v) there is not then in effect any law, rule or regulation prohibiting or
restricting the transactions contemplated hereby, or requiring any consent or approval which shall not have been obtained, nor is there any pending or threatened proceeding or investigation which may have the effect of prohibiting or adversely
affecting any of the transactions contemplated by this Agreement; no statute, rule, regulation, executive order, decree, ruling or injunction shall have been enacted, entered, promulgated or adopted by any court or governmental authority of
competent jurisdiction that prohibits the transactions contemplated by this Agreement, and no actions, suits or proceedings shall be in progress, pending or threatened by any person (other than Investor or any Affiliate of Investor), that seek to
enjoin or prohibit the transactions contemplated by this Agreement. For purposes of this paragraph (v), no proceeding shall be deemed pending or threatened unless one of the parties has received written notification thereof prior to the applicable
Preferred Stock Closing Date; 
 (vi) all Common Shares are DWAC Shares, are DTC eligible and can be immediately
converted into electronic form without restriction on resale; 
 (vii) Company is in compliance with all reporting
requirements in order to maintain listing on its then current Trading Market; 
 (viii) Company has a current, valid and
effective Registration Statement for the sale of the Preferred Stock, the Fee Shares (if any) and the Warrant Shares; 

(ix) Company has a sufficient number of duly authorized shares of Common Stock for issuance in such amount as may be required to
fulfill its obligations pursuant to the Transaction Documents and any outstanding agreements with Investor and any Affiliate of Investor; 

(x) Company has delivered the Warrant to Investor; 

(xi) Company has provided notice of its delivery of the Preferred Stock Notice to all signatories of a Lock-Up Agreement as
required under the Lock-Up Agreement; 
 and 

(xii) the shares of Preferred Stock to be issued at the Preferred Stock Closing, when aggregated with other securities owned by
Investor and its Affiliates, would not result in beneficial ownership by Investor and its Affiliates of more than 9.99% of the outstanding shares of Common Stock of the Company, unless such condition is waived by Investor in writing. For the
purposes of the immediately preceding sentence, beneficial ownership shall be determined in accordance with Section 13(d) of the Exchange Act, and Rule 13d-3 thereunder. 

(e) Documents Required to be Delivered as Conditions to Preferred Stock Closing. The Preferred Stock Closing and
Investor’s obligations hereunder shall additionally be conditioned upon the delivery to Investor of each of the following on or before the Preferred Stock Closing Date: 

(i) a number of Preferred Shares equal to the Maximum Placement shall have been delivered to Investor or an account specified by
Investor for the Preferred Stock Shares; 
  

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 (ii) the following documents: Officer’s Certificate and Lock-Up Agreements;

 (iii) a “Use of Proceeds” certificate, signed by an officer of the Company, and setting forth how the
Aggregate Preferred Stock Price will be applied by the Company; 
 (iv) all Warrant Shares shall have been timely
delivered pursuant to any Exercise Notice delivered to Company at least two days prior to the Preferred Stock Closing Date (and if any such Warrant Shares required to be so delivered are not credited as DWAC Shares by 12:00 p.m. Eastern Time on the
Trading Day following the Exercise Delivery Date, then the Preferred Stock Closing Date shall be extended by one Trading Day for each Trading Day that timely credit of DWAC Shares is not made); and 

(v) all documents, instruments and other writings required to be delivered by the Company to Investor on or before the Preferred
Stock Closing Date pursuant to any provision of this Agreement in order to implement and effect the transactions contemplated herein. 

(f) Mechanics of Preferred Stock Closing. Each of the Company and Investor shall deliver all documents, instruments and
writings required to be delivered by either of them pursuant to Section 2.3(e) of this Agreement at or prior to the Preferred Stock Closing Date. Subject to such delivery, and the satisfaction of the conditions set forth in
Section 2.3(d), the closing of the purchase by Investor of the Preferred Shares shall occur by 5:00 p.m., New York City Time, on the date which is twenty (20) Trading Days following the Preferred Stock Notice Date at the offices of
Investor (the “Preferred Stock Closing Date”). On or before the Preferred Stock Closing Date, Investor shall deliver to the Company the Preferred Stock Purchase Price to be paid for such Preferred Shares. The closing
(“Preferred Stock Closing”) shall occur on the date that both (i) the Company has delivered to Investor all Required Preferred Stock Documents, and (ii) Investor has delivered to the Company such Preferred Stock Purchase
Price. 
 (g) Limitation on Investor’s Obligation to Purchase and Company’s Obligation to Sell.
Notwithstanding anything herein to the contrary, in the event the closing price of the Common Stock during the nineteen (19) Trading Days following the Preferred Stock Notice Date falls below 75% of the Closing Bid Price on the Trading Day
prior to the Preferred Stock Notice Date, then Investor may, at its option, and without penalty, decline to purchase the applicable Preferred Stock Shares on the Preferred Stock Closing Date. 

2.4 Maximum Placement. Investor shall not be obligated to purchase more than One Thousand (1,000) Preferred Shares.

  

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 ARTICLE 3 

TERMINATION 

3.1 Termination. The Investor may elect to terminate this Agreement and the Company’s right to initiate the purchase
and sale of the Preferred Shares under this Agreement (each, a “Termination”) upon the occurrence of any of the following: 

(a) if, at any time before the Preferred Stock Closing Date, either the Company or any director or executive officer of the
Company has engaged in a transaction or conduct related to the Company that has resulted in (i) a SEC enforcement action, or (ii) a civil judgment or criminal conviction for fraud or misrepresentation, or for any other offense that, if
prosecuted criminally, would constitute a felony under applicable law; 
 (b) on any date after a Delisting Event that
lasts for an aggregate of 20 Trading Days; 
 (c) the Company has filed for and/or is subject to any bankruptcy,
insolvency, reorganization or liquidation proceedings or other proceedings for relief under any bankruptcy law or any law for the relief of debtors instituted by or against the Company or any subsidiary of the Company; 

(d) the Company is in default of any loan agreement, equity investment agreement or instrument, or any other Material Agreement,
which default would have a Material Adverse Effect (as defined below); 
 (e) the Company is in default of any material
provision of any agreement with the Investor, or Investor Affiliate following any applicable notice and opportunity to cure; 

(f) upon the occurrence of a Strategic Transaction; 

(g) so long as any Preferred Shares are outstanding, the Company effects or publicly announces its intention to create a security
senior to the Series F Preferred Stock with respect to liquidation rights or substantially altering the capital structure of the Company in a manner that materially adversely effects the rights and preferences of the Series F Preferred Stock;

 (h) the Company has breached any material covenant in this Agreement following any applicable notice and opportunity
to cure; and 
 (i) on the Termination Date. 

3.2 Company Termination. The Company may terminate (a “Company Termination”) this Agreement, except in the
event that the Company is in default hereunder, by providing 30 days advanced written notice (“Termination Notice”) to Investor, by facsimile or electronic mail and overnight courier, at any time. 

3.3 Effect of Termination. The termination of this Agreement will have no effect on any Common Shares, Preferred Shares,
Fee Shares, Warrants or DWAC Shares previously issued or delivered, or on any rights of any holder thereof. Notwithstanding any other provision, the Commitment Fee is payable to Investor despite any termination of this Agreement all fees paid to
Investor or its counsel are non-refundable. 
  

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 ARTICLE 4 

REPRESENTATIONS AND WARRANTIES 

4.1 Representations and Warranties of the Company. Except as set forth under the corresponding section of the Disclosure
Schedules, which Disclosure Schedules shall be deemed a part hereof, the Company hereby makes the representations and warranties and covenants set forth below to Investor: 

(a) Subsidiaries. All of the direct and indirect subsidiaries of the Company are set forth on Schedule 4.1(a). The
Company owns, directly or indirectly, all of the capital stock or other equity interests of each Subsidiary free and clear of any Liens, and all the issued and outstanding shares of capital stock of each Subsidiary are duly authorized, validly
issued, fully paid, non-assessable and free of preemptive and similar rights to subscribe for or purchase securities. If the Company has no subsidiaries, then references in the Transaction Documents to the Subsidiaries will be disregarded.

 (b) Organization and Qualification. Each of the Company and the Subsidiaries is an entity duly incorporated or
otherwise organized, validly existing and in good standing under the laws of the jurisdiction of its incorporation or organization (as applicable), with the requisite power and authority to own and use its properties and assets and to carry on its
business as currently conducted. Neither the Company nor any Subsidiary is in violation or default of any of the provisions of its respective certificate or articles of incorporation, bylaws or other organizational or charter documents. Each of the
Company and the Subsidiaries is duly qualified to conduct business and is in good standing as a foreign corporation or other entity in each jurisdiction in which the nature of the business conducted or property owned by it makes such qualification
necessary, except where the failure to be so qualified or in good standing, as the case may be, could not have or reasonably be expected to result in (i) a material adverse effect on the legality, validity or enforceability of any Transaction
Document, (ii) a material adverse effect on the results of operations, assets, business, prospects or financial condition of the Company and the Subsidiaries, taken as a whole, or (iii) a material adverse effect on the Company’s
ability to perform in any material respect on a timely basis its obligations under any Transaction Document (any of (i), (ii) or (iii), a “Material Adverse Effect”) and no proceeding has been instituted in any such jurisdiction
revoking, limiting or curtailing or seeking to revoke, limit or curtail such power and authority or qualification. 
 (c)
Authorization; Enforcement. The Company has the requisite corporate power and authority to enter into and to consummate the transactions contemplated by each of the Transaction Documents and otherwise to carry out its obligations
hereunder or thereunder. The execution and delivery of each of the Transaction Documents by the Company and the consummation by it of the transactions contemplated hereby or thereby have been duly authorized by all necessary action on the part of
the Company and no further consent or action is required by the Company other than the filing of the Certificate of Designations. Each of the Transaction Documents has been (or upon delivery will be) duly executed by the Company and, when delivered
in accordance with the terms hereof, will constitute the valid and binding obligation of the Company enforceable against the Company in accordance with its terms, subject to applicable bankruptcy, insolvency, fraudulent conveyance, reorganization,
moratorium and similar laws affecting creditors’ rights and remedies generally and general principles of 
  

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equity. Neither the Company nor any Subsidiary is in violation of any of the provisions of its respective certificate or articles of incorporation, by-laws or other organizational or charter
documents except where such violation could not, individually or in the aggregate, constitute a Material Adverse Effect. 

(d) No Conflicts. The execution, delivery and performance of the Transaction Documents by the Company, the issuance and
sale of the Securities and the consummation by the Company of the other transactions contemplated thereby do not and will not (i) conflict with or violate any provision of the Company’s or any Subsidiary’s certificate or articles of
incorporation, bylaws or other organizational or charter documents, or (ii) conflict with, or constitute a default (or an event that with notice or lapse of time or both would become a default) under, result in the creation of any Lien upon any
of the properties or assets of the Company or any Subsidiary, or give to others any rights of termination, amendment, acceleration or cancellation (with or without notice, lapse of time or both) of, any agreement, credit facility, debt or other
instrument (evidencing a Company or Subsidiary debt or otherwise) or other understanding to which the Company or any Subsidiary is a party or by which any property or asset of the Company or any Subsidiary is bound or affected, or
(iii) conflict with or result in a violation of any law, rule, regulation, order, judgment, injunction, decree or other restriction of any court or governmental authority to which the Company or a Subsidiary is subject (including federal and
state securities laws and regulations), or by which any property or asset of the Company or a Subsidiary is bound or affected, or (iv) conflict with or violate the terms of any agreement by which the Company or any Subsidiary is bound or to
which any property or asset of the Company or any Subsidiary is bound or affected; except in the case of each of clauses (ii) and (iii), such as could not have or reasonably be expected to result in a Material Adverse Effect. 

(e) Filings, Consents and Approvals. Neither the Company nor any Subsidiary is required to obtain any consent, waiver,
authorization or order of, give any notice to, or make any filing or registration with, any court or other federal, state, local or other governmental authority or other Person in connection with the execution, delivery and performance by the
Company of the Transaction Documents, other than the filing of the Certificate of Designations and required federal and state securities filings and such filings and approvals as are required to be made or obtained under the applicable Trading
Market rules in connection with the transactions contemplated hereby, each of which has been, or (if not yet required to be filed) shall be, timely filed. 

(f) Issuance of the Securities. The Securities are duly authorized and, when issued and paid for in accordance with the
applicable Transaction Documents, will be duly and validly issued, fully paid and nonassessable, free and clear of all Liens. The Company has reserved from its duly authorized capital stock a number of shares of Common Stock for issuance of the
Securities at least equal to the number of Securities which could be issued pursuant to the terms of this Agreement based on the current anticipated exercise price of the Warrants. 

(g) Capitalization. The capitalization of the Company is as described in the Company’s most recent periodic report
filed with the SEC. The Company has not issued any capital stock since such filing other than as set forth on Schedule 4.1(g). No Person has any right of first refusal, preemptive right, right of participation, or any similar right to
participate in the 
  

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transactions contemplated by the Transaction Documents. Except (i) as a result of purchase and sale of the Securities, (ii) as described in the SEC Reports, or (iii) as set forth
on Schedule 4.1(g), there are no outstanding options, warrants, script rights to subscribe to, calls or commitments of any character whatsoever relating to, or securities, rights or obligations convertible into or exchangeable for, or giving
any Person any right to subscribe for or acquire, any shares of Common Stock, or contracts, commitments, understandings or arrangements by which the Company or any Subsidiary is or may become bound to issue additional shares of Common Stock or
securities convertible into or exercisable for shares of Common Stock. The issuance and sale of the Securities will not obligate the Company to issue shares of Common Stock or other securities to any Person (other than Investor) and will not result
in a right of any holder of Company securities to adjust the exercise, conversion, exchange, or reset price under such securities. All of the outstanding shares of capital stock of the Company are validly issued, fully paid and nonassessable, have
been issued in compliance with all federal and state securities laws, and none of such outstanding shares was issued in violation of any preemptive rights or similar rights to subscribe for or purchase securities. No further approval or
authorization of any stockholder, the Board of Directors of the Company or others is required for the issuance and sale of the shares of the Securities. Except as disclosed in the SEC Reports, there are no stockholders agreements, voting agreements
or other similar agreements with respect to the Company’s capital stock to which the Company is a party or, to the knowledge of the Company, between or among any of the Company’s stockholders. 

(h) SEC Reports; Financial Statements. The Company has filed all reports required to be filed by it under the Act and the
Exchange Act, including pursuant to Section 13(a) or 15(d) thereof, for the two years preceding the Effective Date (or such shorter period as the Company was required by law to file such material) (the foregoing materials, including the
exhibits thereto, being collectively referred to herein as the “SEC Reports”) on a timely basis or has received a valid extension of such time of filing and has filed any such SEC Reports prior to the expiration of any such
extension. As of their respective dates, the SEC Reports complied in all material respects with the requirements of the Act and the Exchange Act and the rules and regulations of the SEC promulgated thereunder, and none of the SEC Reports, when
filed, contained any untrue statement of a material fact or omitted to state a material fact required to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not
misleading. The financial statements of the Company included in the SEC Reports comply in all material respects with applicable accounting requirements and the rules and regulations of the SEC with respect thereto as in effect at the time of filing.
Such financial statements have been prepared in accordance with GAAP, except as may be otherwise specified in such financial statements or the notes thereto and except that unaudited financial statements may not contain all footnotes required by
GAAP, and fairly present in all material respects the financial position of the Company and its consolidated subsidiaries as of and for the dates thereof and the results of operations and cash flows for the periods then ended, subject, in the case
of unaudited statements, to normal, immaterial, year-end audit adjustments. 
 (i) Material Changes. Since the
date of the latest audited financial statements included within the SEC Reports, except as specifically disclosed in the SEC Reports, (i) there has been no event, occurrence or development that has had or that could reasonably be expected to
result in a Material Adverse Effect, (ii) the Company has not incurred any liabilities (contingent or otherwise) other than (A) trade payables and accrued expenses incurred in the 

 

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ordinary course of business consistent with past practice and (B) liabilities not required to be reflected in the Company’s financial statements pursuant to GAAP or required to be
disclosed in filings made with the SEC, (iii) the Company has not altered its method of accounting, (iv) the Company has not declared or made any dividend or distribution of cash or other property to its stockholders or purchased, redeemed
or made any agreements to purchase or redeem any shares of its capital stock and (v) the Company has not issued any equity securities to any officer, director or Affiliate, except pursuant to existing Company stock option plans. The Company
does not have pending before the SEC any request for confidential treatment of information. 
 (j) Litigation.
There is no action, suit, inquiry, notice of violation, proceeding or investigation pending or, to the knowledge of the Company, threatened against or affecting the Company, any Subsidiary or any of their respective properties before or by any
court, arbitrator, governmental or administrative agency or regulatory authority (federal, state, county, local or foreign) (collectively, an “Action”), which (i) adversely affects or challenges the legality, validity or
enforceability of any of the Transaction Documents or the Securities, or (ii) could, if there were an unfavorable decision, have or reasonably be expected to result in a Material Adverse Effect. Neither the Company nor any Subsidiary, nor to
the knowledge of the Company any director or officer thereof, is or has been the subject of any Action involving a claim of violation of or liability under federal or state securities laws or a claim of breach of fiduciary duty. There has not been,
and to the knowledge of the Company, there is not pending or contemplated, any investigation by the SEC involving the Company or any current or former director or officer of the Company. The SEC has not issued any stop order or other order
suspending the effectiveness of any registration statement filed by the Company or any Subsidiary under the Exchange Act or the Act. 

(k) Labor Relations. No material labor dispute exists or, to the knowledge of the Company, is imminent with respect to any
of the employees of the Company, which could reasonably be expected to result in a Material Adverse Effect. 
 (l)
Compliance. Neither the Company nor any Subsidiary (i) is in default under or in violation of (and no event has occurred that has not been waived that, with notice or lapse of time or both, would result in a default by the Company or
any Subsidiary under), nor has the Company or any Subsidiary received notice of a claim that it is in default under or that it is in violation of, any indenture, loan or credit agreement or any other agreement or instrument to which it is a party or
by which it or any of its properties is bound (whether or not such default or violation has been waived), (ii) is in violation of any order of any court, arbitrator or governmental body, or (iii) is or has been in violation of any statute,
rule or regulation of any governmental authority, including without limitation all foreign, federal, state and local laws applicable to its business except in each case as could not have a Material Adverse Effect. 

(m) Regulatory Permits. The Company and the Subsidiaries possess all certificates, authorizations and permits issued by the
appropriate federal, state, local or foreign regulatory authorities necessary to conduct their respective businesses as described in the SEC Reports, except where the failure to possess such permits could not, individually or in the aggregate, have
or reasonably be expected to result in a Material Adverse Effect (“Material Permits”), and neither the Company nor any Subsidiary has received any notice of proceedings relating to the revocation or modification of any Material
Permit. 
  

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 (n) Title to Assets. The Company and the Subsidiaries have good and marketable
title in fee simple to all real property owned by them that is material to the business of the Company and the Subsidiaries and good and marketable title in all personal property owned by them that is material to the business of the Company and the
Subsidiaries, in each case free and clear of all Liens, except for Liens as do not materially affect the value of such property and do not materially interfere with the use made and proposed to be made of such property by the Company and the
Subsidiaries and Liens for the payment of federal, state or other taxes, the payment of which is neither delinquent nor subject to penalties. Any real property and facilities held under lease by the Company and the Subsidiaries are held by them
under valid, subsisting and enforceable leases of which the Company and the Subsidiaries are in compliance. 
 (o)
Patents and Trademarks. The Company and the Subsidiaries have, or have rights to use, all patents, patent applications, trademarks, trademark applications, service marks, trade names, copyrights, licenses and other similar rights that are
necessary or material for use in connection with their respective businesses as described in the SEC Reports and which the failure to so have could have a Material Adverse Effect (collectively, the “Intellectual Property Rights”).
Neither the Company nor any Subsidiary has received a written notice that the Intellectual Property Rights used by the Company or any Subsidiary violates or infringes upon the rights of any Person. To the knowledge of the Company, all such
Intellectual Property Rights are enforceable and there is no existing infringement by another Person of any of the Intellectual Property Rights of the Company. 

(p) Insurance. The Company and the Subsidiaries are insured by insurers of recognized financial responsibility against such
losses and risks and in such amounts as are prudent and customary in the businesses in which the Company and the Subsidiaries are engaged, including but not limited to directors and officers insurance coverage at least equal to the Maximum
Placement. To the best of Company’s knowledge, such insurance contracts and policies are accurate and complete. Neither the Company nor any Subsidiary has any reason to believe that it will not be able to renew its existing insurance coverage
as and when such coverage expires or to obtain similar coverage from similar insurers as may be necessary to continue its business without a significant increase in cost. 

(q) Transactions With Affiliates and Employees. Except as set forth in the SEC Reports, none of the officers or directors
of the Company and, to the knowledge of the Company, none of the employees of the Company is presently a party to any transaction with the Company or any Subsidiary (other than for services as employees, officers and directors), including any
contract, agreement or other arrangement providing for the furnishing of services to or by, providing for rental of real or personal property to or from, or otherwise requiring payments to or from any officer, director or such employee or, to the
knowledge of the Company, any entity in which any officer, director, or any such employee has a substantial interest or is an officer, director, trustee or partner, in each case in excess of $120,000 other than (i) for payment of salary or
consulting fees for services rendered, (ii) reimbursement for expenses incurred on behalf of the Company and (iii) for other employee benefits, including stock option agreements under any stock option plan of the Company. 

 

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 (r) Sarbanes-Oxley; Internal Accounting Controls. The Company is in material
compliance with all provisions of the Sarbanes-Oxley Act of 2002, which are applicable to it as of the date of the Commitment Closing. The Company and the Subsidiaries maintain a system of internal accounting controls sufficient to provide
reasonable assurance that (i) transactions are executed in accordance with management’s general or specific authorizations, (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with
GAAP and to maintain asset accountability, (iii) access to assets is permitted only in accordance with management’s general or specific authorization, and (iv) the recorded accountability for assets is compared with the existing
assets at reasonable intervals and appropriate action is taken with respect to any differences. The Company has established disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) for the Company and designed
such disclosure controls and procedures to ensure that material information relating to the Company, including its Subsidiaries, is made known to the certifying officers by others within those entities, particularly during the period in which the
Company’s most recently filed periodic report under the Exchange Act, as the case may be, is being prepared. The Company’s certifying officers have evaluated the effectiveness of the Company’s controls and procedures as of the date
prior to the filing date of the most recently filed periodic report under the Exchange Act (such date, the “Evaluation Date”). The Company presented in its most recently filed periodic report under the Exchange Act the conclusions
of the certifying officers about the effectiveness of the disclosure controls and procedures based on their evaluations as of the Evaluation Date. Except as disclosed in the SEC Reports, since the Evaluation Date, there have been no significant
changes in the Company’s internal controls (as such term is defined in Item 307(b) of Regulation S-K under the Exchange Act) or, to the Company’s knowledge, in other factors that could significantly affect the Company’s internal
controls. 
 (s) Certain Fees. Except for payment of the Commitment Fee, no brokerage or finder’s fees or
commissions are or will be payable by the Company to any broker, financial advisor or consultant, finder, placement agent, investment banker, bank or other Person with respect to the transactions contemplated by this Agreement. Investor shall have
no obligation with respect to any fees or with respect to any claims made by or on behalf of other Persons, as a result of agreements made by the Company or its officers or directors, for fees of a type contemplated in this
Section 4.1(s) that may be due in connection with the transactions contemplated by this Agreement. 
 (t)
Investment Company. The Company is not, and is not an Affiliate of, and immediately after receipt of payment for the Securities, will not be or be an Affiliate of, an “investment company” within the meaning of the Investment
Company Act of 1940, as amended. The Company shall conduct its business in a manner so that it will not become subject to the Investment Company Act. 

(u) Registration Rights. No Person has any right to cause the Company to effect the registration under the Act of any
securities of the Company. 
  

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 (v) Listing and Maintenance Requirements. The Common Stock is registered
pursuant to Section 12(g) of the Exchange Act, and the Company has taken no action designed to, or which to its knowledge is likely to have the effect of, terminating the registration of the Common Stock under the Exchange Act nor has the
Company received any notification that the SEC is contemplating terminating such registration. The Company has not, in the 12 months preceding the Effective Date, received notice from any Trading Market on which the Common Stock is or has been
listed or quoted to the effect that the Company is not in compliance with the listing or maintenance requirements of such Trading Market. The Company is, and has no reason to believe that it will not in the foreseeable future continue to be, in
compliance with all such listing and maintenance requirements. 
 (w) Application of Takeover Protections. The
Company and its Board of Directors have taken all necessary action, if any, in order to render inapplicable any control share acquisition, business combination, poison pill (including any distribution under a rights agreement) or other similar anti
takeover provision under the Company’s Certificate of Incorporation (or similar charter documents) or the laws of its state of incorporation that is or could become applicable to Investor as a result of Investor and the Company fulfilling their
obligations or exercising their rights under the Transaction Documents, including without limitation the Company’s issuance of the Securities and Investor’s ownership of the Securities. 

(x) Disclosure. The Company confirms that, except with respect to the information that will be, and to the extent that it
timely is, publicly disclosed pursuant to Section 2.2(b)(i)(E), neither the Company nor any other Person acting on its behalf has provided Investor or its agents or counsel with any information that constitutes or might constitute
material, non-public information including without limitation in the Disclosure Schedules. The Company understands and confirms that Investor will rely on the foregoing representations and covenants in effecting transactions in securities of the
Company. All disclosure provided to Investor regarding the Company, its business and the transactions contemplated hereby, including the Schedules to this Agreement, furnished by or on behalf of the Company with respect to the representations and
warranties made herein are true and correct with respect to such representations and warranties and do not contain any untrue statement of a material fact or, when taken together, omit to state any material fact necessary in order to make the
statements made therein, in light of the circumstances under which they were made, not misleading. The Company acknowledges and agrees that no Investor makes or has made any representations or warranties with respect to the transactions contemplated
hereby other than those specifically set forth in Section 4.2 hereof. The Company understands and confirms that neither Investor nor any Affiliate of Investor shall have any duty of trust or confidence that is owed directly, indirectly,
or derivatively to the Company or the shareholders of the Company or to any other Person who is the source of material non-public information regarding the Company. 

(y) No Integrated Offering. Neither the Company, nor any of its Affiliates, nor any Person acting on its or their behalf
has, directly or indirectly, made any offers or sales of any security or solicited any offers to buy any security, under circumstances that would cause this offering of the Securities to be integrated with prior offerings by the Company for purposes
of the Act or which could violate any applicable stockholder approval provisions, including, without limitation, under the rules and regulations of the Trading Market. 
  


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 (z) Financial Condition/Indebtedness. Based on the financial condition of the
Company as of the date of the Commitment Closing: (i) the fair saleable market value of the Company’s assets exceeds the amount that will be required to be paid on or in respect of the Company’s existing debts and other liabilities
(including known contingent liabilities) as they mature; (ii) the Company’s assets do not constitute unreasonably small capital to carry on its business for the current fiscal year as now conducted and as proposed to be conducted including
its capital needs taking into account the particular capital requirements of the business conducted by the Company, and projected capital requirements and capital availability thereof; and (iii) the current cash flow of the Company, together
with the proceeds the Company would receive, were it to liquidate all of its assets, after taking into account all anticipated uses of the cash, would be sufficient to pay all amounts on or in respect of its debt when such amounts are required to be
paid. The Company does not intend to incur debts beyond its ability to pay such debts as they mature (taking into account the timing and amounts of cash to be payable on or in respect of its debt). The Company has no knowledge of any facts or
circumstances, which lead it to believe that it will file for reorganization or liquidation under the bankruptcy or reorganization laws of any jurisdiction within one year from the date of the Commitment Closing. The SEC Reports set forth as of the
dates thereof all outstanding secured and unsecured Indebtedness of the Company or any Subsidiary, or for which the Company or any Subsidiary has commitments. Neither the Company nor any Subsidiary is in default with respect to any Indebtedness.

 (aa) Tax Status. The Company and each of its Subsidiaries has made or filed all federal, state and foreign
income and all other tax returns, reports and declarations required by any jurisdiction to which it is subject (unless and only to the extent that the Company and each of its Subsidiaries has set aside on its books provisions reasonably adequate for
the payment of all unpaid and unreported taxes) and has paid all taxes and other governmental assessments and charges that are material in amount, shown or determined to be due on such returns, reports and declarations, except those being contested
in good faith and has set aside on its books provisions reasonably adequate for the payment of all taxes for periods subsequent to the periods to which such returns, reports or declarations apply. There are no unpaid taxes in any material amount
claimed to be due by the taxing authority of any jurisdiction, and the officers of the Company know of no basis for any such claim. The Company has not executed a waiver with respect to the statute of limitations relating to the assessment or
collection of any foreign, federal, statue or local tax. None of the Company’s tax returns is presently being audited by any taxing authority. 

(bb) Foreign Corrupt Practices. Neither the Company, nor to the knowledge of the Company, any agent or other person acting
on behalf of the Company, has (i) directly or indirectly, used any corrupt funds for unlawful contributions, gifts, entertainment or other unlawful expenses related to foreign or domestic political activity, (ii) made any unlawful

  

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payment to foreign or domestic government officials or employees or to any foreign or domestic political parties or campaigns from corporate funds, (iii) failed to disclose fully any
contribution made by the Company (or made by any person acting on its behalf of which the Company is aware) which is in violation of law, or (iv) violated in any material respect any provision of the Foreign Corrupt Practices Act of 1977, as
amended. 
 (cc) Acknowledgment Regarding Investor’s Purchase of Securities. The Company acknowledges and
agrees that Investor is acting solely in the capacity of arm’s length purchaser with respect to this Agreement and the transactions contemplated hereby. The Company further acknowledges that Investor is not acting as a financial advisor or
fiduciary of the Company (or in any similar capacity) with respect to this Agreement and the transactions contemplated hereby and any statement made by Investor or any of its representatives or agents in connection with this Agreement and the
transactions contemplated hereby is not advice or a recommendation and is merely incidental to Investor’s purchase of the Securities. The Company further represents to Investor that the Company’s decision to enter into this Agreement has
been based solely on the independent evaluation of the Company and its representatives. 
 (dd) Accountants. The
Company’s accountants are set forth in the SEC Reports. To the Company’s knowledge, such accountants are a registered public accounting firm as required by the Act. 

(ee) No Disagreements with Accountants and Lawyers. There are no disagreements of any kind presently existing, or
reasonably anticipated by the Company to arise, between the accountants and lawyers formerly or presently employed by the Company and the Company is current with respect to any fees owed to its accountants and lawyers. 

(ff) Registration Statements and Prospectuses. 

(i) The Registration Statement complies, and at all times during which a prospectus is required by the Act to be delivered in
connection with any sale of Preferred Stock or Warrant Shares, will comply, in all material respects, with the requirements of the Act. 

(ii) The Registration Statement, as of its effective time, did not contain any untrue statement of a material fact or omit to
state a material fact required to be stated therein or necessary to make the statements therein not misleading. 
 (iii)
Each prospectus (within the meaning of the Act) related to the sale or offering of any Common Shares (“Prospectus”) will comply, as of its date and the date it will be filed with the SEC, and, at the time of the Preferred Stock
Closing Date, or issuance of any Warrant Shares, and at all times during which a prospectus is required by the Act to be delivered in connection with any issuance of Warrant Shares, will comply, in all material respects, with the requirements of the
Act. 
 (iv) At no time during the period that begins on the date a Prospectus is filed with the SEC and ends at the
time a prospectus is no longer required by the Act to be delivered in connection with any sale of Common Shares did or will any such Prospectus, as then amended or supplemented, include an untrue statement of a material fact or omit to state a
material fact necessary in order to make the statements therein, in the light of the circumstances 
  

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under which they were made, not misleading, and at no time during such period will such Prospectus, as then amended or supplemented, include an untrue statement of a material fact or omit to
state a material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading. 

(v) The Company has not, directly or indirectly, used or referred to any “free writing prospectus” (as defined in Rule
405 under the Act) except in compliance with Rules 164 and 433 under the Act. 
 (vi) The Company is not an
“ineligible issuer” (as defined in Rule 405 under the Act) as of the eligibility determination date for purposes of Rules 164 and 433 under the Act with respect to the offering of the Common Shares contemplated by any Registration
Statement, without taking into account any determination by the SEC pursuant to Rule 405 under the Act that it is not necessary under the circumstances that the Company be considered an “ineligible issuer”. 

(ii) Investor’s Trading Activity. The Company understands and acknowledges that: (i) Investor has not been asked
by the Company to agree, nor has Investor agreed, to desist from purchasing or selling, long and/or short, securities of the Company or “derivative” securities based on securities issued by the Company, or to hold the Securities for any
specified term; (ii) past or future open market or other transactions by Investor, specifically including, without limitation, short sales or “derivative” transactions, before or after the Closing, may negatively impact the market
price of the Company’s publicly-traded securities; (iii) Investor and counter-parties in “derivative” transactions to which Investor is a party, directly or indirectly, presently may have a “short” position in the
Common Stock; (iv) Investor shall not be deemed to have any affiliation with or control over any arm’s length counter-party in any “derivative” transaction; (v) Investor may engage in hedging activities at various times
during the period that the Securities are outstanding, including, without limitation, during the periods that the value of the Warrant Shares deliverable with respect to Securities are being determined; (vi) such hedging activities (if any)
could reduce the value of the existing stockholders’ equity interests in the Company at and after the time that the hedging activities are being conducted; and (vii) the aforementioned hedging activities do not and will not constitute a
breach of this Agreement or any of the other Transaction Documents. 
 4.2 Representations and Warranties of
Investor. Investor hereby represents and warrants as of the Effective Date as follows: 
 (a) Organization;
Authority. Investor is an entity validly existing and in good standing under the laws of the jurisdiction of its organization with full right, company power and authority to enter into and to consummate the transactions contemplated by the
Transaction Documents and otherwise to carry out its obligations thereunder. The execution, delivery and performance by Investor of the transactions contemplated by this Agreement have been duly authorized by all necessary company or similar action
on the part of Investor. Each Transaction Document to which it is a party has been (or will be) duly executed by Investor, and when delivered by Investor in accordance with the terms hereof, will constitute the valid and legally binding obligation
of Investor, enforceable against it in accordance with its terms, except (i) as limited by general equitable principles and applicable bankruptcy, insolvency, reorganization, 

 

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moratorium and other laws of general application affecting enforcement of creditors’ rights generally, (ii) as limited by laws relating to the availability of specific performance,
injunctive relief or other equitable remedies and (iii) insofar as indemnification and contribution provisions may be limited by applicable law. The principal executive office of Investor is the address provided for notices pursuant to this
Agreement. 
 (b) No Other Representations. The Company acknowledges and agrees that Investor does not make or has
not made any representations or warranties with respect to the transactions contemplated hereby other than those specifically set forth in this Section 4.2. 

ARTICLE 5 

OTHER AGREEMENTS OF THE PARTIES 

5.1 Issuance of Securities. All of the Securities shall be issued free of restrictive legends. The Company agrees, if
requested by Investor or the transfer agent, to promptly provide at the Company’s expense a legal opinion of counsel to the Company confirming this. The Company further acknowledges and agrees that Investor may from time to time pledge pursuant
to a bona fide margin agreement with a registered broker-dealer or grant a security interest in some or all of the Securities to a financial institution that is an “accredited investor” as defined in Rule 501(a) under the Act and who
agrees to be bound by the provisions of this Agreement and, if required under the terms of such arrangement, Investor may transfer pledged or secured Securities to the pledgees or secured parties. Such a pledge or transfer would not be subject to
approval of the Company and no legal opinion of legal counsel of the pledgee, secured party or pledgor shall be required in connection therewith. Further, no notice shall be required of such pledge. At Investor’s reasonable expense, the Company
will execute and deliver such documentation as a pledgee or secured party of Securities may reasonably request in connection with a pledge or transfer of the Securities. 

5.2 Furnishing of Information. As long as Investor owns Securities, the Company covenants to timely file (or obtain
extensions in respect thereof and file within the applicable grace period) all reports required to be filed by the Company after the Effective Date pursuant to the Exchange Act. Upon the request of Investor, the Company shall deliver to Investor a
written certification of a duly authorized officer as to whether it has complied with the preceding sentence. As long as Investor owns Securities, if the Company is not required to file reports pursuant to such laws, it will prepare and furnish to
Investor and make publicly available in accordance with Rule 144(c) such information as is required for Investor to sell the Securities under Rule 144. The Company further covenants that it will take such further action as any holder of Securities
may reasonably request, all to the extent required from time to time to enable such Person to sell such Securities without registration under the Act within the limitation of the exemptions provided by Rule 144. 

5.3 Integration. The Company shall not sell, offer for sale or solicit offers to buy or otherwise negotiate in respect of
any security (as defined in Section 2 of the Act) that would be integrated with the offer or sale of the Securities in a manner that would require the registration under the Act of the sale of the Securities to Investor or that would be
integrated with the offer or sale of the Securities for purposes of the rules and regulations of any Trading Market such that it would require stockholder approval prior to the closing of such other transaction unless stockholder approval is
obtained before the closing of such subsequent transaction. 
  

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 5.4 Securities Laws Disclosure; Publicity. The Company shall, by 8:30 a.m.
Eastern time on the Trading Day following the Effective Date, issue a press release and as required by this Agreement file a Current Report on Form 8-K, in each case reasonably acceptable to Investor, disclosing the material terms of the
transactions contemplated hereby. The Company and Investor shall consult with each other in issuing any press releases with respect to the transactions contemplated hereby, and neither the Company nor Investor shall issue any such press release or
otherwise make any such public statement without the prior consent of the Company, with respect to any such press release of Investor, or without the prior consent of Investor, with respect to any such press release of the Company, which consent
shall not unreasonably be withheld, except if such disclosure is required by law, in which case the disclosing party shall promptly provide the other party with prior notice of such public statement or communication. Notwithstanding the foregoing,
the Company shall not publicly disclose the name of Investor, or include the name of Investor in any filing with the SEC or any regulatory agency or Trading Market, without the prior written consent of Investor, except (i) as required by
federal securities law in connection with any registration statement under which the Common Shares are registered, and (ii) to the extent such disclosure is required by law or Trading Market regulations, in which case the Company shall provide
Investor with prior notice of such disclosure permitted under subclause (i) or (ii). 
 5.5 Shareholders Rights
Plan. No claim will be made or enforced by the Company or, to the knowledge of the Company, any other Person that Investor is an “Acquiring Person” under any shareholders rights plan or similar plan or arrangement in effect or
hereafter adopted by the Company, or that Investor could be deemed to trigger the provisions of any such plan or arrangement, by virtue of receiving Securities under the Transaction Documents or under any other agreement between the Company and
Investor. The Company shall conduct its business in a manner so that it will not become subject to the Investment Company Act of 1940, as amended. 

5.6 Non-Public Information. The Company covenants and agrees that neither it nor any other Person acting on its behalf will
provide Investor or its agents or counsel with any information that the Company believes constitutes material non-public information, unless prior thereto Investor shall have executed a written agreement regarding the confidentiality and use of such
information. The Company understands and confirms that Investor shall be relying on the foregoing representations in effecting transactions in securities of the Company. 

5.7 Reimbursement. If Investor becomes involved in any capacity in any proceeding by or against any Person who is a
stockholder of the Company (except as a result of sales, pledges, margin sales and similar transactions by Investor to or with any current stockholder), solely as a result of Investor’s acquisition of the Securities under this Agreement, the
Company will reimburse Investor for its reasonable legal and other expenses (including the cost of any investigation preparation and travel in connection therewith) incurred in connection therewith, as such expenses are incurred, or will assume the
defense of Investor in such matter. The reimbursement obligations of the Company under this Section 5.7 shall be in addition to any liability which the Company may otherwise have, shall extend upon the same terms and conditions to any
Affiliates of Investor who are actually named in such action, proceeding or 
  

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investigation, and partners, directors, agents, employees and controlling persons (if any), as the case may be, of Investor and any such Affiliate, and shall be binding upon and inure to the
benefit of any successors, assigns, heirs and personal representatives of the Company, Investor and any such Affiliate and any such Person. The Company also agrees that neither Investor nor any such Affiliates, partners, directors, agents, employees
or controlling persons shall have any liability to the Company or any Person asserting claims on behalf of or in right of the Company solely as a result of acquiring the Securities under this Agreement. 

5.8 Indemnification of Investor. Subject to the provisions of this Section 5.8, the Company will
indemnify and hold Investor and any Warrant holder, their Affiliates and attorneys, and each of their directors, officers, shareholders, partners, employees, agents, and any person who controls Investor within the meaning of Section 15 of the
Act or Section 20 of the Exchange Act (collectively, the “Investor Parties” and each an “Investor Party”), harmless from any and all losses, liabilities, obligations, claims, contingencies, damages, costs and
expenses, including all judgments, amounts paid in settlements, court costs and reasonable attorneys’ fees and costs of investigation that any Investor Party may suffer or incur as a result of or relating to (a) any breach of any of the
representations, warranties, covenants or agreements made by the Company in this Agreement or in the other Transaction Documents, (b) any action instituted against any Investor Party, or any of them or their respective Affiliates, by any
stockholder of the Company who is not an Affiliate of an Investor Party, with respect to any of the transactions contemplated by the Transaction Documents (unless such action is based upon a breach of Investor’s representations, warranties or
covenants under the Transaction Documents or any agreements or understandings Investor may have with any such stockholder or any violations by Investor of state or federal securities laws or any conduct by Investor which constitutes fraud, gross
negligence, willful misconduct or malfeasance), (c) any untrue statement or alleged untrue statement of a material fact contained in a Registration Statement (or in a Registration Statement as amended by any post-effective amendment thereof by
the Company) or arising out of or based upon any omission or alleged omission to state a material fact required to be stated therein or necessary to make the statements therein not misleading, and/or (d) any untrue statement or alleged untrue
statement of a material fact included in any Prospectus ( or any amendments or supplements to any Prospectus ), in any free writing prospectus, in any “issuer information” (as defined in Rule 433 under the Act) of the Company, or in any
Prospectus together with any combination of one or more of the free writing prospectuses, if any, or arising out of or based upon any omission or alleged omission to state a material fact necessary in order to make the statements therein, in the
light of the circumstances under which they were made, not misleading. 
 If any action shall be brought against an Investor
Party in respect of which indemnity may be sought pursuant to this Agreement, such Investor Party shall promptly notify the Company in writing, and the Company shall have the right to assume the defense thereof with counsel of its own choosing. The
Investor Parties shall have the right to employ separate counsel in any such action and participate in the defense thereof, but the fees and expenses of such counsel shall be at the expense of the Investor Parties except to the extent that
(i) the employment thereof has been specifically authorized by the Company in writing, (ii) the Company has failed after a reasonable period of time to assume such defense and to employ counsel or (iii) in such action there is, in the
reasonable opinion of such separate counsel, a material conflict with respect to the dispute in question on any material issue between the 

 

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position of the Company and the position of the Investor Parties such that it would be inappropriate for one counsel to represent the Company and the Investor Parties. The Company will not be
liable to the Investor Parties under this Agreement (i) for any settlement by an Investor Party effected without the Company’s prior written consent, which shall not be unreasonably withheld or delayed; or (ii) to the extent, but only
to the extent that a loss, claim, damage or liability is either attributable to Investor’s breach of any of the representations, warranties, covenants or agreements made by Investor in this Agreement or in the other Transaction Documents or is
a result of any information provided by Investor or its representatives to Company in writing for inclusion in the Registration Statement. 

5.9 Reservation of Securities. The Company shall maintain a reserve from its duly authorized shares of Common Stock
for issuance pursuant to the Transaction Documents in such amount as may be required to fulfill its obligations in full under the Transaction Documents. 

5.10 Limited Standstill. The Company will deliver to Investor on or before the each Preferred Stock Closing Date and will
honor and will take reasonable actions to assist Investor in enforcing the provisions of the Lock-Up Agreements with the Company’s officers, directors and beneficial owners of 10% or more of the Common Stock. 

5.11 Issuance of Additional Securities. The Company shall not issue additional Common Stock or securities convertible into
Common Stock to any Person other than Investor, or an Investor Affiliate, if such issuance would reduce the number of remaining authorized shares of Common Stock that could be issued below the number of remaining authorized shares issuable upon
exercise of the Warrants, without previously amending its Certificate of Incorporation to increase the number of duly authorized shares of Common Stock by at least the amount necessary to assume a sufficient number of shares to permit the exercise
of all outstanding Warrants. 
 5.12 Prospectus Availability and Changes. The Company will make available to
Investor upon request, and thereafter from time to time to furnish Investor, as many copies of any Prospectus (or of the Prospectus as amended or supplemented if the Company shall have made any amendments or supplements thereto after the effective
date of the applicable Registration Statement) as Investor may request for the purposes contemplated by the Act; and in case Investor is required to deliver a prospectus after the nine-month period referred to in Section 10(a)(3) of the Act in
connection with the sale of the Common Shares, or after the time a post-effective amendment to the applicable Registration Statement is required pursuant to Item 512(a) of Regulation S-K under the Act, the Company will prepare, at its expense,
promptly upon request such amendment or amendments to the Registration Statement and the Prospectus as may be necessary to permit compliance with the requirements of Section 10(a)(3) of the Act or Item 512(a) of Regulation S-K under the
Act, as the case may be. 
 The Company will advise Investor promptly of the happening of any event within the time during which
a Prospectus is required to be delivered under the Act which could require the making of any change in the Prospectus then being used so that the Prospectus would not include an untrue statement of material fact or omit to state a material fact
necessary in order to make the statements therein, in the light of the circumstances under which they are made, not misleading, and to advise Investor promptly if, during such period, it shall become necessary to amend or supplement any Prospectus
to cause such Prospectus to comply with the requirements of the Act, and in each case, during such time, to prepare and furnish, at the Company’s expense, to Investor promptly such amendments or supplements to such Prospectus as may be
necessary to reflect any such change or to effect such compliance. 
  

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 5.13 Activity Restrictions. For so long as Investor or any of its Affiliates
holds any Preferred Shares, Commitment Fee Shares, Warrant, Warrant Shares, or DWAC Shares, neither Investor nor any Affiliate will: (i) vote any shares of Common Stock owned or controlled by it, solicit any proxies, or seek to advise or
influence any Person with respect to any voting securities of the Company; (ii) engage or participate in any actions, plans or proposals which relate to or would result in (a) acquiring additional securities of the Company, alone or
together with any other Person, which would result in beneficially owning or controlling more than 9.99% of the total outstanding Common Stock or other voting securities of the Company, (b) an extraordinary corporate transaction, such as a
merger, reorganization or liquidation, involving Company or any of its subsidiaries, (c) a sale or transfer of a material amount of assets of the Company or any of its subsidiaries, (d) any change in the present board of directors or
management of the Company, including any plans or proposals to change the number or term of directors or to fill any existing vacancies on the board, (e) any material change in the present capitalization or dividend policy of the Company,
(f) any other material change in the Company’s business or corporate structure, including but not limited to, if the Company is a registered closed-end investment company, any plans or proposals to make any changes in its investment policy
for which a vote is required by Section 13 of the Investment Company Act of 1940, (g) changes in the Company’s charter, bylaws or instruments corresponding thereto or other actions which may impede the acquisition of control of the
Company by any Person, (h) causing a class of securities of the Company to be delisted from a national securities exchange or to cease to be authorized to be quoted in an inter-dealer quotation system of a registered national securities
association, (i) a class of equity securities of the Company becoming eligible for termination of registration pursuant to Section 12(g)(4) of the Act, or (j) any action, intention, plan or arrangement similar to any of those
enumerated above; or (iii) request the Company or its directors, officers, employees, agents or representatives to amend or waive any provision of this Section 5.13. 

5.14 Required Approval. No transactions contemplated under this Agreement or the Transaction Documents shall be consummated
for an amount that would require approval by any Trading Market or Company stockholders under any approval provisions, rules or regulations of any Trading Market applicable to the Company, unless and until such approval is obtained. Company shall
use best efforts to obtain any required approval as soon as possible. 
 5.15 Investor Due Diligence. Investor
shall have the right and opportunity to conduct due diligence, at its own expense, with respect to any Registration Statement or Prospectus in which the name of Investor or any Affiliate of Investor appears. 

ARTICLE 6 

MISCELLANEOUS 

6.1 Fees and Expenses. Prior to the Effective Date, the Company shall have paid a $20,000.00 non-refundable document
preparation fee to counsel for Investor. This fee amount shall be adjusted to reflect the actual hours billed to Investor by such counsel and any additional payment made by the Company to such counsel on or prior to the Preferred Stock Closing Date.
Except as may be otherwise set forth in this Agreement, each party shall pay the fees and 
  

 25 








 
expenses of its advisers, counsel, accountants and other experts, if any, and all other expenses incurred by such party incident to the negotiation, preparation, execution, delivery and
performance of this Agreement. The Company acknowledges and agrees that Luce, Forward, Hamilton & Scripps LLP solely represents Investor, and does not represent the Company or its interests in connection with the Transaction Documents or
the transactions contemplated thereby. The Company shall pay all stamp and other taxes and duties levied in connection with the sale of the Securities, if any, to Investor by the Company. 

6.2 Notices. Unless a different time of day or method of delivery is set forth in the Transaction Documents, any and all
notices or other communications or deliveries required or permitted to be provided hereunder shall be in writing and shall be deemed given and effective on the earliest of (a) the date after the day of transmission, if such notice or
communication is delivered via facsimile at the facsimile number specified on the signature page prior to 5:00 p.m. (New York City time) on a Trading Day and an electronic confirmation of delivery is received by the sender, (b) two Trading Days
after the date of transmission, if such notice or communication is delivered via facsimile at the facsimile number specified in this Section 6.2 on a day that is not a Trading Day or later than 5:00 p.m. (New York City time) on any Trading Day,
(c) three Trading Days following the date of mailing, if sent by U.S. nationally recognized overnight courier service, or (d) upon actual receipt by the party to whom such notice is required to be given. The addresses for such notices and
communications are those set forth on the signature pages hereof, or such other address as may be designated in writing hereafter, in the same manner, by such Person. 

6.3 Amendments; Waivers. No provision of this Agreement may be waived or amended except in a written instrument signed, in
the case of an amendment, by the Company and Investor or, in the case of a waiver, by the party against whom enforcement of any such waiver is sought. No waiver of any default with respect to any provision, condition or requirement of this Agreement
shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default or a waiver of any other provision, condition or requirement hereof, nor shall any delay or omission of either party to exercise any right hereunder in any
manner impair the exercise of any such right. 
 6.4 Headings. The headings herein are for convenience only, do
not constitute a part of this Agreement and shall not be deemed to limit or affect any of the provisions hereof. 
 6.5
Successors and Assigns. This Agreement shall be binding upon and inure to the benefit of the parties and their successors and permitted assigns. The Company may not assign this Agreement or any rights or obligations hereunder without the
prior written consent of Investor, which consent will not be unreasonably withheld or delayed. Investor may assign any or all of its rights under this Agreement to (a) any Affiliate, and (b) any Person to whom Investor assigns or transfers
any Securities, provided such transferee agrees in writing to be bound, with respect to the transferred Securities, by the provisions hereof that apply to the “Investor”. 

6.6 No Third-Party Beneficiaries. This Agreement is intended for the benefit of the parties hereto and their respective
successors and permitted assigns and is not for the benefit of, nor may any provision hereof be enforced by, any other Person, except as otherwise set forth in Section 5.8. 

 

 26 








 6.7 Governing Law; Dispute Resolution. All questions concerning the
construction, validity, enforcement and interpretation of the Transaction Documents shall be governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles of conflicts of law
thereof. Each party agrees that all legal proceedings concerning the interpretations, enforcement and defense of the transactions contemplated by this Agreement and any other Transaction Documents (whether brought against a party hereto or its
respective affiliates, directors, officers, shareholders, employees or agents) shall be commenced exclusively in the state and federal courts sitting in the City of New York. Each party hereby irrevocably submits to the exclusive jurisdiction of the
state and federal courts sitting in the City of New York, borough of Manhattan for the adjudication of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein (including with respect to the
enforcement of any of the Transaction Documents), and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such suit, action or
proceeding is improper or inconvenient venue for such proceeding. Each party hereby irrevocably waives personal service of process and consents to process being served in any such suit, action or proceeding by mailing a copy thereof via registered
or certified mail or overnight delivery (with evidence of delivery) to such party at the address in effect for notices to it under this Agreement and agrees that such service shall constitute good and sufficient service of process and notice
thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any manner permitted by law. The parties hereby waive all rights to a trial by jury. If either party shall commence an action or proceeding to
enforce any provisions of the Transaction Documents, then the prevailing party in such action or proceeding shall be reimbursed by the other party for its attorneys’ fees and other costs and expenses incurred with the investigation, preparation
and prosecution of such action or proceeding. 
 6.8 Survival. The representations and warranties contained herein
shall survive the Closing and the delivery, exercise and/or conversion of the Securities, as applicable. 
 6.9
Execution. This Agreement may be executed in two or more counterparts, all of which when taken together shall be considered one and the same agreement and shall become effective when counterparts have been signed by each party and
delivered to the other party, it being understood that both parties need not sign the same counterpart. In the event that any signature is delivered by facsimile transmission or in a PDF file by e-mail transmission, such signature shall create a
valid and binding obligation of the party executing (or on whose behalf such signature is executed) with the same force and effect as if such facsimile signature page were an original thereof. 

6.10 Severability. If any provision of this Agreement is held to be invalid or unenforceable in any respect, the validity
and enforceability of the remaining terms and provisions of this Agreement shall not in any way be affected or impaired thereby and the parties will attempt to agree upon a valid and enforceable provision that is a reasonable substitute therefor,
and upon so agreeing, shall incorporate such substitute provision in this Agreement. 
 6.11 Replacement of
Securities. If any certificate or instrument evidencing any Securities is mutilated, lost, stolen or destroyed, the Company shall issue or cause to be issued in exchange and substitution for and upon cancellation thereof, or in lieu of and
substitution 
  

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therefor, a new certificate or instrument, but only upon receipt of evidence reasonably satisfactory to the Company of such loss, theft or destruction and customary and reasonable indemnity, if
requested. The applicants for a new certificate or instrument under such circumstances shall also pay any reasonable third-party costs associated with the issuance of such replacement Securities. 

6.12 Remedies. In addition to being entitled to exercise all rights provided herein or granted by law, including recovery
of damages, each of Investor and the Company will be entitled to specific performance under the Transaction Documents. The parties agree that monetary damages may not be adequate compensation for any loss incurred by reason of any breach of
obligations described in the foregoing sentence and hereby agrees to waive in any action for specific performance of any such obligation the defense that a remedy at law would be adequate. Neither the Company nor Investor shall be liable for
special, indirect, consequential or punitive damages suffered or alleged to be suffered by the other party or any third party, whether arising from or related to the Transaction Documents or otherwise. 

6.13 Payment Set Aside. To the extent that the Company makes a payment or payments to Investor pursuant to any Transaction
Document or Investor enforces or exercises its rights thereunder, and such payment or payments or the proceeds of such enforcement or exercise or any part thereof are subsequently invalidated, declared to be fraudulent or preferential, set aside,
recovered from, disgorged by or are required to be refunded, repaid or otherwise restored to the Company, a trustee, receiver or any other person under any law (including, without limitation, any bankruptcy law, state or federal law, common law or
equitable cause of action), then to the extent of any such restoration the obligation or part thereof originally intended to be satisfied shall be revived and continued in full force and effect as if such payment had not been made or such
enforcement or setoff had not occurred. 
 6.14 Liquidated Damages. The Company’s obligations to pay any
partial liquidated damages or other amounts owing under the Transaction Documents is a continuing obligation of the Company and shall not terminate until all unpaid partial liquidated damages and other amounts have been paid notwithstanding the fact
that the instrument or security pursuant to which such partial liquidated damages or other amounts are due and payable shall have been canceled. 

6.15 Construction. The parties agree that each of them and/or their respective counsel has reviewed and had an opportunity
to revise the Transaction Documents and, therefore, the normal rule of construction to the effect that any ambiguities are to be resolved against the drafting party shall not be employed in the interpretation of the Transaction Documents or any
amendments hereto. 
 6.16 Time of the Essence. Time is of the essence with respect to all provisions of this
Agreement that specify a time for performance. 
 6.17 Entire Agreement. The Transaction Documents, together with
the exhibits and schedules thereto, contain the entire understanding of the parties, and supersede all prior and contemporaneous agreements, term sheets, communications, discussions and understandings, oral or written, which the parties acknowledge
have been merged into such documents, exhibits and schedules. Neither party has relied upon any agreement, promise or representation not expressly set forth in the Transaction Documents and each party agrees that it may only rely on the agreements,
promises and representations set forth therein. 
  

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 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed by
their respective authorized signatories as of the date first indicated above. 
  

			
	INTERNATIONAL STEM CELL CORPORATION
		
	By:	 	  

		 	Kenneth C. Aldrich, Chairman
	
	Investor
		
	By:	 	  


  

 29 








 Addresses for Notice 

 

			
	 To Company:
	 	
		
	International Stem Cell Corporation:	 	
	2595 Jason Court	 	
	Oceanside, CA 92056	 	
	Attention: Kenneth C. Aldrich, Chairman	 	
	Fax No.: (760) 940-6387	 	
	Email: kaldrich@intlstemcell.com	 	
		
	with a copy (which shall not constitute notice) to:	 	
		
	DLA Piper LLP (US)	 	
	4365 Executive Drive, Suite 1100	 	
	San Diego, CA 92121	 	
	Attention: Douglas J. Rein	 	
	Fax: (858) 677-1401	 	
	Email: doug.rein@dlapiper.com	 	
		
	 To Investor:
	 	
		
		 	
		
	  
	 	
		
	  
	 	
		
	Fax No.:______________________________________________	 	
		
	Email:________________________________________________	 	
		
	with a copy (which shall not constitute notice) to:	 	

  
  

 30 








 Exhibit D 

Lock-Up Agreement 

[Date] 
  

	
	  

	  



Ladies and Gentlemen: 
 This
Lock-Up Agreement is being delivered to you in connection with the Preferred Stock Purchase Agreement dated as of April [    ], 2010 (“Purchase Agreement”) and entered into by and among the undersigned and
                             (“Investor”), with respect to the purchase pursuant to
registration under the Securities Act of 1933, as amended (the “Act”) of shares of Series F Preferred Stock and related Securities of International Stem Cell Corporation, a Delaware corporation (“Company”).
Capitalized terms used herein without definition shall have the respective meanings ascribed to them in the Purchase Agreement. 

In order to induce Investor to enter into the Purchase Agreement, the undersigned agrees that, for a period of seven Trading Days
beginning on the date the Company delivers a Preferred Stock Notice to Investor (the “Preferred Stock Notice Date”) and ending of after the Preferred Stock Closing Date pursuant to the terms of the Purchase Agreement (the
“Lock-up Period”), the undersigned will not, without the prior written consent of Investor, (a) sell, offer to sell, contract or agree to sell, hypothecate, pledge, grant any option to purchase or otherwise dispose of or agree
to dispose of, directly or indirectly, in respect of, or establish or increase a put equivalent position or liquidate or decrease a call equivalent position within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended,
and the rules and regulations of the SEC promulgated thereunder (the “Exchange Act”) with respect to, any Common Stock of the Company or any securities convertible into or exercisable or exchangeable for Common Stock, or warrants or
other rights to purchase Common Stock or any such securities, or any securities substantially similar to the Common Stock, (b) enter into any swap or other arrangement that transfers to another, in whole or in part, any of the economic
consequences of ownership of Common Stock or any securities convertible into or exercisable or exchangeable for Common Stock or any such securities, or warrants or other rights to purchase Common Stock, whether any such transaction is to be settled
by delivery of Common Stock or such other securities, in cash or otherwise or (c) publicly announce an intention to effect any transaction specified in clause (a) or (b). 

The foregoing sentence shall not apply to (a) bona fide gifts, provided the recipient thereof agrees in writing to be bound by the
terms of this Lock-Up Agreement, (b) dispositions to any trust for the direct or indirect benefit of the undersigned and/or the immediate family of the undersigned, provided that such trust agrees in writing to be bound by the terms of this
Lock-Up Agreement, (c) sales made pursuant to any written sales plans established prior to the date of this Lock-Up Agreement in conformity with the requirements of Rule 10b5-1(c) promulgated under the Exchange Act or (d) exercise of
options for Common Stock and the disposition 
  

 1 








 
(whether by sale, gift or otherwise) of Common Stock underlying such options. Notwithstanding subsection (a) above, the undersigned may make a bona fide gift of up to 10,000 shares of
Common Stock to a charity or other non-profit entity and such charity or entity shall not be required to be bound by the terms of this Lock-Up Agreement; provided, however, that in the event the undersigned exercises options during the Lock-Up
Period, the undersigned may not, during the Lock-Up Period, dispose of the number of shares of Common Stock underlying such exercised options equal to the number of shares of Common Stock gifted by the undersigned pursuant to this sentence during
the Lock-Up Period. For purposes of this paragraph, “immediate family” shall mean the undersigned and the spouse, any lineal descendent, father, mother, brother or sister of the undersigned. 

The Company agrees to provide the undersigned with notice that the Company has delivered a Preferred Stock Notice to Investor prior to,
or simultaneous with, its delivery of the Preferred Stock Notice to Investor. Such notice shall provide the undersigned with the Preferred Stock Notice Date and clearly indicate the beginning of the Lock-up Period. 

Upon the termination of the Purchase Agreement, this Lock-Up Agreement shall be terminated and the undersigned shall be released from its
obligations hereunder. 
  

	
	Sincerely,
	
	  

	[Stockholder]


 Acknowledged and Agreed: 

 

			
	International Stem Cell Corporation
		
	By:	 	  


  


 2