Initial to indicate certification as to information on this page (full text of certification is on page one). Date INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary. 2. Case # and Name 3. Date and Type of DCI and Number

4. EPA Product Registration 5. I wish to cancel this product registration voluntarily 6. Generic Data 7. Product Specific Data 6a. I am claiming a Generic Data Exemption because I obtain the active ingredient from the source EPA registration number listed below. 6b. I agree to satisfy Generic Data Requirements as indicated on the attached form entitled "Requirements Status and Registrant's Response." 7a. My product is an MUP and I agree to satisfy the MUP requirement on the attached form entitled "Requirements Status and Registrant's Response." 7b. My product is an EUP and I agree to satisfy the EUP requirement on the attached form entitled "Requirements Status and Registrant's Response." OMB Approval 2070-0174

1. Company Name and Address 0245 - Fenbutatin-oxide Chemical # and Name: 104601 Fenbutatin-oxide 15-Apr-2011 GENERIC ID # GDCI-104601-834 

### United States Environmental Protection Agency

Washington, D.C. 20460 DATA CALL-IN RESPONSE 1 Page of 1

8. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law. Signature and Title of Company's Authorized Representative ______________________________________________________ 10. Name of Company N/A N/A

9. Date

11. Phone NumberInitial to indicate certification as to information on this page (full text of certification is on page one) 13. Phone Number 10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.
12. Name of Company 11. Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________

Environmental Fate Data Requirements (Conventional Chemical)

Nontarget Plant Protection Data Requirements (Conventional Chemical)

Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical) 835.4300 835.4400

850.4100 850.4150 850.4400 850.5400 Aerobic aquatic metabolism

Anaerobic aquatic metabolism

Terrestrial Plant Toxicity (Seedling Emergence) Terrestrial plant toxicity, Tier 1 (vegetative vigor) Aquatic plant toxicity test using Lemna spp. Tiers I and II Algal toxicity, Tiers 1 and II 0245 - Fenbutatin-oxide Chemical # and Name: 104601 Fenbutatin-oxide 15-Apr-2011 GENERIC ID # GDCI-104601-834

U,S,A,O,K,R,C,B,Q U,S,A,O,K,R,C,B,Q

U,S,A,O,K,R,C,B,Q U,S,A,O,K,R,C,B,Q U,S,A,O,K,R,C,B,Q U,S,A,O,K,R,C,B,Q EP; PAI; TGAI EP; PAI; TGAI

TEP TEP EP; PAI; TGAI EP; PAI; TGAI 24 24

12 12 12 12 1 of Page

(6, 11, 23) (5, 11, 23) (14, 23) (13, 24) Y

Y

N N N N 3OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical)

Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical),Environmental Fate Data Requirements (Conventional Chemical) 850.1010 850.1075 850.1350 850.1400 850.2100

850.1730 Aquatic invertebrate acute toxicity, test, freshwater

daphnids Fish acute toxicity test, freshwater and marine Mysid chronic toxicity test Fish early-life stage toxicity test Avian acute oral toxicity test

Fish BCF 0245 - Fenbutatin-oxide Chemical # and Name: 104601 Fenbutatin-oxide 15-Apr-2011 GENERIC ID # GDCI-104601-834

U,S,A,O,K,R,C,B,Q U,S,A,O,K,R,C,B,Q U,S,A,O,K,R,C,B,Q U,S,A,O,K,R,C,B,Q U,S,A,O,K,R,C,B,Q

U,S,A,O,K,R,C,B,Q EP; PAI; TGAI EP; PAI; TGAI TGAI TGAI EP; PAI; TGAI

EP; PAI; TGAI 12 12 12 12 12

12 2 of Page

(10) (8, 10) (17) (15, 18) (12, 16) N

N N N Y

N 3Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Toxicology Data Requirements (Conventional Chemical) 870.3465 870.6200 870.7600

8501735S 8501740S 870.7800 90-day inhalation toxicity

Neurotoxicity screening battery Dermal penetration
Whole Sediment Chronic Tox (Freshwater) Whole Sediment Chronic Tox (Estuarine) Immunotoxicity 0245 - Fenbutatin-oxide Chemical # and Name: 104601 Fenbutatin-oxide 15-Apr-2011 GENERIC ID # GDCI-104601-834

U,S,A,O,K,R,C,B,Q U,S,A,O,K,R,C,B,Q U,S,A,O,K,R,C,B,Q

U,S,A,O,K,R,C,B,Q U,S,A,O,K,R,C,B,Q U,S,A,O,K,R,C,B,Q TGAI TGAI CHOICE

EP; PAI; TGAI EP; PAI; TGAI TGAI 12 24 12

12 12 12 3 of Page

(20) (21)

(1, 2, 3, 9, 19, 22) (1, 4, 7, 9, 19, 22) N

Y N

Y Y Y 3

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS 0245 - Fenbutatin-oxide GDCI-104601-834

1 2 3 4 5 6 7 8 9 10 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

The preferred sediment is formulated; guidance for the formulated sediment can be found in OECD 218 Sediment-Water Chironomid Toxicity Test using Spiked Sediment. Test Method 100.5: Life-cycle Test for Measuring the Effects of Sediment-associated Contaminants on Chironomus dilutus (formerly known as C. tentans) in USEPA 2000 Methods for Measuring the Toxicity and Bioaccumulation of Sediment-associated Contaminants with Freshwater Invertebrates EPA 6001R-99/064 Required in order to fulfill the data requirements and reduce the uncertainties associated with a lack of sediment toxicity data, 28-day spiked sediment studies (with suitable range finding tests) should be completed with fenbutatin-oxide per OPPTS Guidelines 850.1735 for sediment dwelling freshwater. Required in order to fulfill the data requirements and reduce the uncertainties associated with a lack of sediment toxicity data, 28-day spiked sediment studies (with suitable range finding tests) should be completed with fenbutatin-oxide per OPPTS Guideline 850.1740 for sediment dwelling estuarine/marine invertebrates. Refer to public draft guideline 850.4250 for guidance on Tier II vegetative vigor testing. Refer to public draft guideline 850.4225 for guidance on Tier II seedling emergence testing. Leptocheirus plumulosus in USEPA 2001 Method for Assessing the Chronic Toxicity of Marine and Estuarine Sediment-associated Contaminants with the Amphipod Leptocheirus plumulosus EPA 6001R-0l/020 Freshwater fish LC50 (use most sensitive of the species tested), and acute LC50/EC50 estuarine and marine organisms. For alternative test designs, the protocol should discuss the power of the test. Data are required on flow through systems. Currently available data on static systems are not adequate to fulfill the guideline. Case # and Name: DCI Number: 1 Page: of

Footnotes: The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement. Use Categories Key: A - Terrestrial food crop B - Terrestrial feed crop C - Terrestrial nonfood crop K - Residential O - Residential Indoor use Q - Residential outdoor use R - Agricultural premises and equipment S - Food handling/storage establishments premises and equipment U - Residential and public access premises 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS 0245 - Fenbutatin-oxide GDCI-104601-834

11 12 13 14 15 16 17 18 19

20 21 22 23

24 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

Data are required for six species of dicots from at least four families, one species of which is soybean (Glycine max). Data are required for four species of monocots from at least two families, one species which is corn (Zea mays). At least one of either the monocot or dicot species must be a root crop. Data are required for passerine bird species. A protocol must be submitted prior to initiation of this study. Data are required for a freshwater green alga species, a freshwater diatom species, a marine diatom species, and a cyanobacterium (formerly known as blue-green algae). Data are required for a duckweed species. Data are preferred on sheepshead minnow (Cypinodon variegatus). Data are preferred on redwing blackbird (Agelaius phoneiceus). Data are preferred on mysid shrimp (Americamysis bahia). Data are needed on estuarine/marine fish only. Based on test variability for the endpoint of concern and the need to establish a NOAEC/LOAEC the following number of replicates and test animals are recommended: for the midge test with C. dilutus 16 replicates containing 12 test organisms each (12 replicates at test initiation; 4 added at 10 days for auxillary males); for the freshwater amphipod H. azteca test of 12 replicates per treatment (4 for 28-d survival and growth and 8 for the remainder of the test) with 10 neonates per replicate; and for the L. plumulosus 10 replicates per treatment with 20 neonates per replicate. Based on estimates of the magnitude and duration of human exposure, studies of shorter duration, e.g., 21 or 28-days, may be sufficient to satisfy this requirement. Registrants should consult with the Agency to determine whether studies of shorter duration would meet this requirement. Additional measurements such as cholinesterase activity for certain pesticides, e.g., organophosphates and some carbamates, will also be required. The route of exposure must correspond with the primary route of exposure. A protocol should be submitted for approval prior to testing. A Tier II study is required. A Tier I plant study may be conducted in lieu of a Tier II study with the understanding that any adverse effects observed by the Tier I study would necessitate conduct and submission of a Tier II study as well. The purpose of a Tier II study is to establish both a definitive No Observed Adverse Effect Concentration (NOAEC), or alternatively, a concentration at which there is a 5% observed inhibition effect (IC05), to be used in a risk assessment and effects determination for endangered or threatened species (listed species), and a definitive IC25 (concentration at which there is a 25% observed inhibition effect) for assessing risk to non-listed nontarget plants. If any adverse effects are observed in a Tier I study and neither a definitive NOAEC nor a definitive IC05 value is available, then the Agency may have to presume in its effects determination, that Fenbutatin oxide "may affect" and is ¿likely to adversely affect¿ listed plant species. A Tier II study is required. A Tier I plant study may be conducted in lieu of a Tier II study with the understanding that any adverse effects observed by the Tier I study would necessitate conduct and submission of a Tier II study as well. The purpose of a Tier II study is to establish both a definitive No Observed Adverse Effect Concentration (NOAEC), or alternatively, a concentration at which there is a 5% observed inhibition effect (IC05), to be used in a risk assessment and effects determination for endangered or threatened species (listed species), and a definitive IC25 (concentration at which there is a 25% observed inhibition effect) for assessing risk to non-listed nontarget plants. If any adverse effects are observed in a Tier I study and neither a definitive NOAEC nor a definitive IC05 value is available, then the Agency may have to presume in its effects determination, that Fenbutatin oxide "may affect" and is "likely to adversely affect" listed plant species. Case # and Name: DCI Number: 2 Page: of 2

### United States Environmental Protection Agency Washington, D.C. 20460 LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE 0245 - Fenbutatin-oxide Case # and Name: 1 Page: of 1

70506 UNITED PHOSPHORUS, INC Co. Nr. Company Name Agent For Company 630 FREEDOM BUSINESS CENTER, SUITE 402 Address City ZIP KING OF PRUSSIA 19406 OMB Approval 2070-0174

State PA DCI Number: GDCI-104601-834

# LINKS TO FORMS: The pesticide registration forms that are listed below can be found at: http://www.epa.gov/opprd001/forms/ Link to C onfidential Statement of Formula and Instructions (Form # 8570 -4 

# ) http://www.epa.gov/opprd001/forms/8570 - 4.pdf C ertification of Attempt to Enter Into an Agreement With Registrants for Development of Data (Form # 8570 - 32 

# ) http://www.epa.gov/opprd001/forms/8570 - 32.pdf
C ertification With Respect to Citation of Data (Form # 8570 - 34 

# ) http://www.epa.gov/opprd001/forms/8570 - 34.pdf