Exhibit 10.34

Execution Version



*** Text Omitted and Filed Separately

Confidential Treatment Requested

Under 17 C.F.R. §§ 200.80(b)(4)

and 240.24b-2









SECOND AMENDMENT TO LOAN AND SECURITY
AGREEMENT



THIS SECOND AMENDMENT
TO LOAN AND SECURITY AGREEMENT (this “Amendment”), dated as of March 2, 2017 (the “Second
Amendment Effective Date”), is entered into by and among Sorrento Therapeutics, Inc., a Delaware corporation (“Parent”),
Concortis Biosystems, Corp., a Delaware corporation, Ark Animal Health, Inc., a Delaware corporation, TNK Therapeutics, Inc., a
Delaware corporation, Sorrento Biologics, Inc., a Delaware corporation, Scintilla Pharmaceuticals, Inc., a Delaware corporation,
LA Cell, Inc., a Delaware corporation, SiniWest Holding Corp., a Delaware corporation, Levena Biopharma US, Inc., a Delaware corporation,
BioServ Corporation (formerly known as Sorrento BioServices, Inc.), a Delaware corporation, Scilex Pharmaceuticals Inc., a Delaware
corporation, SNAN Holdco LLC, a Delaware limited liability company, and each of their Qualified Subsidiaries (together with “Parent”
hereinafter collectively referred to as the “Borrower”), the several banks and other financial institutions
or entities from time to time parties thereto as Lender, constituting the Required Lenders, and HERCULES CAPITAL, INC., formerly
known as Hercules Technology Growth Capital, Inc., a Maryland corporation, in its capacity as administrative agent and collateral
agent for itself and the Lender (in such capacity, together with its successors and assigns in such capacity, “Agent”).



The Borrower, the Lender
and Agent are parties to a Loan and Security Agreement dated as of November 23, 2016 (as amended by that certain First Amendment
to Loan and Security Agreement dated as of December 27, 2016, and as may be further amended, restated or modified from time to
time, the “Loan and Security Agreement”). The Borrower has requested that the Lender agree to certain amendments
to the Loan and Security Agreement. The Lender has agreed to such request, subject to the terms and conditions hereof.



Accordingly, the parties
hereto agree as follows:



SECTION 1Definitions; Interpretation.



(a)Terms Defined in Loan and Security Agreement. All capitalized terms used in this
Amendment (including in the recitals hereof) and not otherwise defined herein shall have the meanings assigned to them in the
Loan and Security Agreement.



(b)Interpretation. The rules of interpretation set forth in Section 1.1 of the Loan and Security Agreement shall
be applicable to this Amendment and are incorporated herein by this reference.



SECTION 2Amendments to the Loan and Security Agreement.



(a)The Loan and Security Agreement shall be amended as follows effective as of the Second Amendment Effective Date:



1







(i)New Definitions. The following definitions are added to Section 1.1 in their proper alphabetical order:



[...***...]



“Second
Amendment Effective Date” means March 2, 2017.



(ii)Amended Definition. The following definition is hereby amended as follows:



The definition of “Permitted
Indebtedness” is hereby amended by removing the word “and” before clause (xv), renumbering the current cause
(xv) as clause (xvi) and inserting the following as a new clause (xv):



“(xv)
[...***...]; and”



(b)References Within Loan and Security Agreement. Each reference in the Loan and Security Agreement to “this Agreement”
and the words “hereof,” “herein,” “hereunder,” or words of like import, shall mean and be a
reference to the Loan and Security Agreement as amended by this Amendment.



SECTION
3Conditions of Effectiveness. The effectiveness of Section 2 of this Amendment shall be subject
to the satisfaction of each of the following conditions precedent:



(a)Fees and Expenses. The Borrower shall have paid (i) all attorney fees and other costs and expenses then due in accordance
with Section 5(e), and (ii) all other fees, costs and expenses, if any, due and payable as of the Second Amendment Effective
Date under the Loan and Security Agreement.



(b)This Amendment. Agent shall have received this Amendment, executed by Agent, the Lender and the Borrower.



(c)Representations and Warranties; No Default. On the Second Amendment Effective Date, after giving effect to the amendment
of the Loan and Security Agreement contemplated hereby:



(i)The representations and warranties contained in Section 4 shall be true and correct in all material respects on and
as of the Second Amendment Effective Date as though made on and as of such date; and



*Confidential
Treatment Requested

2





(ii)There exist no Events of Default or events that with the passage of time would result in an Event of Default.



SECTION
4Representations
and Warranties. To induce Agent and Lender to enter into this Amendment, the Borrower hereby confirms, as of the date hereof,
(a) that the representations and warranties made by it in Section 5 of the Loan and Security Agreement and in the other Loan Documents
are true and correct in all material respects; provided, however, that such materiality qualifier shall not be applicable
to any representations and warranties that already are qualified or modified by materiality in the text thereof; (b) that there
has not been and there does not exist a Material Adverse Change; and (c) that the information included in the Perfection Certificate
delivered to Agent on the Effective Date remains true and correct. For the purposes of this Section 4, any representations
and warranties which relate solely to an earlier date shall not be deemed confirmed and restated as of the date hereof (provided
that such representations and warranties shall be true, correct and complete in all material respects as of such earlier date).



SECTION
5Acknowledgment.
Each of Lender and Agent acknowledges and agrees that Borrower’s completion of the [...***...] by March 15, 2017 pursuant
to which Borrower receives net proceeds of at least $43,250,000 shall constitute Borrower’s achievement of the Initial Fundraising
Requirement pursuant to the Loan and Security Agreement.



SECTION 6Miscellaneous.



(a)Loan Documents Otherwise Not Affected; Reaffirmation. Except as expressly amended pursuant hereto or referenced herein,
the Loan and Security Agreement and the other Loan Documents shall remain unchanged and in full force and effect and are hereby
ratified and confirmed in all respects. The Lender’s and Agent’s execution and delivery of, or acceptance of, this
Amendment shall not be deemed to create a course of dealing or otherwise create any express or implied duty by any of them to provide
any other or further amendments, consents or waivers in the future. The Borrower hereby reaffirms the grant of security under Section
3.1 of the Loan and Security Agreement and hereby reaffirms that such grant of security in the Collateral secures all Secured Obligations
under the Loan and Security Agreement, including without limitation any Term Loans funded on or after the Second Amendment Effective
Date, as of the date hereof.



(b)Conditions. For purposes of determining compliance with the conditions specified in Section 3, each Lender
that has signed this Amendment shall be deemed to have consented to, approved or accepted or to be satisfied with, each document
or other matter required thereunder to be consented to or approved by or acceptable or satisfactory to a Lender unless Agent shall
have received notice from such Lender prior to the Second Amendment Effective Date specifying its objection thereto.



(c) Release. In consideration of the agreements of Agent and each Lender contained herein and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, Borrower, on behalf of itself and its successors,
assigns, and other legal representatives, hereby fully, absolutely, unconditionally and irrevocably releases, remises and forever
discharges Agent and each Lender, and its successors and assigns, and its present and



*Confidential
Treatment Requested

3







former shareholders,
affiliates, subsidiaries, divisions, predecessors, directors, officers, attorneys, employees, agents and other representatives
(Agent, Lenders and all such other persons being hereinafter referred to collectively as the “Releasees” and
individually as a “Releasee”), of and from all demands, actions, causes of action, suits, covenants, contracts,
controversies, agreements, promises, sums of money, accounts, bills, reckonings, damages and any and all other claims, counterclaims,
defenses, rights of set-off, demands and liabilities whatsoever of every name and nature, known or unknown, suspected or unsuspected,
both at law and in equity, which Borrower, or any of its successors, assigns, or other legal representatives may now or hereafter
own, hold, have or claim to have against the Releasees or any of them for, upon, or by reason of any circumstance, action, cause
or thing whatsoever which arises at any time on or prior to the day and date of this Amendment, including, without limitation,
for or on account of, or in relation to, or in any way in connection with the Loan and Security Agreement, or any of the other
Loan Documents or transactions thereunder or related thereto. Borrower understands, acknowledges and agrees that the release set
forth above may be pleaded as a full and complete defense and may be used as a basis for an injunction against any action, suit
or other proceeding which may be instituted, prosecuted or attempted in breach of the provisions of such release. Borrower agrees
that no fact, event, circumstance, evidence or transaction which could now be asserted or which may hereafter be discovered shall
affect in any manner the final, absolute and unconditional nature of the release set forth above.



(d)No Reliance. The Borrower hereby acknowledges and confirms to Agent and the Lender that the Borrower is executing
this Amendment on the basis of its own investigation and for its own reasons without reliance upon any agreement, representation,
understanding or communication by or on behalf of any other Person.



(e)Costs and Expenses. The Borrower agrees to pay to Agent on the Second Amendment Effective Date the out-of-pocket
costs and expenses of Agent and the Lenders party hereto, and the fees and disbursements of counsel to Agent and the Lenders party
hereto (including allocated costs of internal counsel), in connection with the negotiation, preparation, execution and delivery
of this Amendment and any other documents to be delivered in connection herewith on the Second Amendment Effective Date or after
such date.



(f)Binding Effect. This Amendment binds and is for the benefit of the successors and permitted assigns of each party.



(g)Governing Law. This Amendment, the Loan and Security Agreement and the other Loan Documents shall be governed by,
and construed and enforced in accordance with, the laws of the State of California, excluding conflict of laws principles that
would cause the application of laws of any other jurisdiction.



(h)Complete Agreement; Amendments. This Amendment and the Loan Documents represent the entire agreement about this subject
matter and supersede prior negotiations or agreements with respect to such subject matter. All prior agreements, understandings,
representations, warranties, and negotiations between the parties about the subject matter of this Amendment and the Loan Documents
merge into this Amendment and the Loan Documents.





4







(i)Severability of Provisions.Each provision of this Amendment is severable from every other provision in determining
the enforceability of any provision.



(j)Counterparts. This Amendment may be executed in any number of counterparts and by different parties on separate counterparts,
each of which, when executed and delivered, is an original, and all taken together, constitute one Amendment. Delivery of an executed
counterpart of a signature page of this Amendment by facsimile, portable document format (.pdf) or other electronic transmission
will be as effective as delivery of a manually executed counterpart hereof.



(k)Loan Documents. This Amendment shall constitute a Loan Document.



[Balance of Page
Intentionally Left Blank; Signature Pages Follow]



5







IN WITNESS WHEREOF,
the parties hereto have duly executed this Amendment, as of the date first above written.



| | BORROWER:                  
| | ---------------------------
| |                            
| | SORRENTO THERAPEUTICS, INC.
| |                            
| | Signature:                 
| |                            
| | Print Name:                
| |                            
| | Title:                     
| |                            
| |                            
| |                            
| | CONCORTIS BIOSYSTEMS, CORP.
| |                            
| | Signature:                 
| |                            
| | Print Name:                
| |                            
| | Title:                     
| |                            
| |                            
| |                            
| | ARK ANIMAL HEALTH, INC.    
| |                            
| | Signature:                 
| |                            
| | Print Name:                
| |                            
| | Title:                     
| |                            
| |                            
| |                            
| | SORRENTO BIOLOGICS, INC.   
| |                            
| | Signature:                 
| |                            
| | Print Name:                
| |                            
| | Title:                     





[Signature Page to Second Amendment to Loan and Security Agreement (Sorrento/Hercules)]









| | TNK THERAPEUTICS, INC.         
| | -------------------------------
| |                                
| | Signature:                     
| |                                
| | Print Name:                    
| |                                
| | Title:                         
| |                                
| |                                
| |                                
| | SCINTILLA PHARMACEUTICALS, INC.
| |                                
| | Signature:                     
| |                                
| | Print Name:                    
| |                                
| | Title:                         
| |                                
| |                                
| |                                
| | LA CELL, INC.                  
| |                                
| | Signature:                     
| |                                
| | Print Name:                    
| |                                
| | Title:                         
| |                                
| |                                
| |                                
| | SINIWEST HOLDING CORP.         
| |                                
| | Signature:                     
| |                                
| | Print Name:                    
| |                                
| | Title:                         
| |                                
| |                                
| |                                
| | LEVENA BIOPHARMA US INC.       
| |                                
| | Signature:                     
| |                                
| | Print Name:                    
| |                                
| | Title:                         





[Signature Page to Second Amendment to Loan and Security Agreement (Sorrento/Hercules)]







| | BIOSERV CORPORATION        
| | ---------------------------
| |                            
| | Signature:                 
| |                            
| | Print Name:                
| |                            
| | Title:                     
| |                            
| |                            
| |                            
| | SCILEX PHARMACEUTICALS INC.
| |                            
| | Signature:                 
| |                            
| | Print Name:                
| |                            
| | Title:                     
| |                            
| |                            
| |                            
| | SNAN HOLDCO LLC            
| |                            
| | Signature:                 
| |                            
| | Print Name:                
| |                            
| | Title:                     





[Signature Page to Second Amendment to Loan and Security Agreement (Sorrento/Hercules)]









| | AGENT:                
| | ----------------------
| |                       
| | HERCULES CAPITAL, INC.
| |                       
| | Signature:            
| |                       
| | Print Name:           
| |                       
| | Title:                
| |                       
| |                       
| |                       
| | LENDER:               
| |                       
| | HERCULES CAPITAL, INC.
| |                       
| | Signature:            
| |                       
| | Print Name:           
| |                       
| | Title:                





[Signature Page to Second Amendment to Loan and Security Agreement (Sorrento/Hercules)]