SAT Report

PMN Number: P-11-0483

SAT Date: 7/19/2011

Print Date: 5/1/2013

Related cases:

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 2 3 Health: PMN ; Eco: 

2 3 Health: Deg Pdt ; Eco: high concern for toxicity of incomplete incineration

products to terrestrial organisms

 Persistence Bioaccum Toxicity Comments

3 32

Exposure Based Review:

Health: No

Ecotox: Yes

Routes of exposure: Health: Dermal Drinking Water Inhalation 

Ecotox: All releases to water

Fate: ;

P2Rec Comments:

Comment: No Comment

Keywords:

 Keywords: 

IRR-E,S,L,MM

LIVER

SENS

UNCERT NEURO

UNCERT MUTA

LIVER

BLOOD

MALE REPRO
IMMUNO

ONCO

AQUATOX-C

Summary of Assessment:

 Fate:

Fate Summary: P-11-0483

FATE: 

log Kow = 5.82 (E) 

VP = 6.5 torr at 25 C (NOMO5)

H = 9.96E+2 (E)

log Koc = 5.45 (E)

log Fish BCF = 3.50 (E)

log Fish BAF = 4.51 (E) 

POTW removal (%) = 50-90 via sorption and stripping

Time for complete ultimate aerobic biodeg > mo

Sorption to soils/sediments = moderate

Volatilization half-life from a standard river = 2 hrs

Volatilization half-life from a standard lake = 8 da

Atmospheric Oxidation Half-life = 3.1 hr via OH radical

PBT Potential: P3B3

*CEB FATE: Migration to ground water = moderate

 Health:

 Health Summary: Absorption is moderate all routes, based on analogs. The 

thiol constituent can form in the body, and the PMN substance can be metabolized to 

 There are concerns for irritation to all exposed tissues, liver toxicity, 

and sensitization, as well as uncertain concern for neurotoxicity, based on thiols and information 

in the PMN MSDS. There also is concern for sensitization based on the possible 

formation. There also is uncertain concern for mutagenicity based on compounds.

For the potential degradation product, based on test data for the analog 

concerns are liver toxicity, blood toxicity, and male reproductive toxicity [rat 28-day oral 

NOAEL = 50 mg/kg, LOAEL = 150 mg/kg with liver toxicity; rat 90-day oral LOAEL = 10 

mg/kg based on decreased body weight in males at all doses and liver toxicity and anemia at 200 

mg/kg; there were toxic effects on the testes in 2 males in the 90-day oral study that were judged 

by the reviewer to be indicative of the potential for male reproductive toxicity. There is also 

concern for immunosuppression and oncogenicity based on data for 
 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 0.033

daphnid 48-h LC50 0.058

green algal 96-h EC50 0.049

fish _ chronic value 0.006

daphnid _ chronic 

value

0.005

algal _ chronic 

value

0.036

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for thiols; SAR chemical class = 

thiol- MW 380; log Kow = 5.82 (EPI), 5.42 (ACD); pH7; effective concentrations 

based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as 

CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

1

SARs thiols

SAR Class thiol new chemicals category: thiols

Ecotox Category 

Ecotox Factors Comments: 

 SAT Chair: J. Kwiat