U.S. ENVIRONMENTAL PROTECTION AGENCY Office of Pesticide Programs Biopesticides and Pollution Prevention Division (7511P) 1200 Pennsylvania Ave., N.W.

Washington, D.C. 20460 EPA Reg. Number:
73049-500 Date of Issuance:
9/25/2015

NOTICE OF PESTICIDE: X Registration Reregistration Term of Issuance: Unconditional (under FIFRA, as amended) Name of Pesticide Product: Leap ® Biological Insecticide Emulsifiable Suspension Name and Address of Registrant (include ZIP Code): Valent Biosciencies Corporation 870 Technology Way, Suite 100 Libertyville, IL 60048
Note:Changes in labeling differing in substance from that accepted in connection with this registration must be submitted to and ac cepted by the Biopesticides and Pollution Prevention Division prior to use of the label in commerce. In any correspondence on this product, always refer to the above EPA Registration Number. On the basis of information furnished by the registrant, the above named pesticide is hereby registered under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA or the Act). Registration is in no way to be construed as an endorsement or recommendation of this product by the U.S. Environmental Protection Agency (EPA). In order to protect health and the environment, the Administrator, on his or her motion, may at any time suspend or cancel the registration of a pesticide in accordance with the Act. The acceptance of any name in connection with the registration of a product under the Act is not to be construed as giving the registrant a right to exclusive use of the name or to its use if it has been covered by others. This product is unconditionally registered in accordance with FIFRA section 3(c)(5) provided that you: 1. Submit and/or cite all data required for registration or registration review of your product when the EPA requires all registrants of similar products to submit such data. 2. Submit storage stability and corrosion characteristics (Guidelines 830.6317 and 830.6320) data as these data requirements are not satisfied. A one-year study is required to satisfy these data requirements. You have 18 months from the date of this registration to provide these data to the EPA.

Signature of Approving Official:

Andrew Bryceland, Team Leader Biochemical Pesticides Branch Biopesticides and Pollution Prevention Division (7511P) Office of Pesticide Programs Date:

9/25/2015

EPA Form 8570-6Page 2 of 2 EPA Reg. No. 73049-500 OPP Decision No. 489428

3. Make the following labeling change before you release this product for shipment:

x Revise the EPA Registration Number to read, “EPA Reg. No. 73049-500.” 4. Submit one (1) copy of the final printed labeling for the record before you release this product for shipment. Should you wish to add/retain a reference to your company’s website on your label, then please be aware that the website becomes labeling under FIFRA and is subject to review by the EPA. If the website is false or misleading, the product will be considered to be misbranded and sale or distribution of the product is unlawful under FIFRA section 12(a)(1)(E). 40 CFR § 156.10(a)(5) lists examples of statements the EPA may consider false or misleading. In addition, regardless of whether a website is referenced on your product’s label, claims made on the website may not substantially differ from those claims approved through the registration process. Therefore, should the EPA find or if it is brought to our attention that a website contains false or misleading statements or claims substantially differing from the EPA-approved registration, the website will be referred to the EPA’s Office of Enforcement and Compliance Assurance. Your release for shipment of this product constitutes acceptance of these terms. If these terms are not complied with, this registration will be subject to cancellation in accordance with FIFRA section 6. A stamped copy of the labeling is enclosed for your records. Please also note that the record for this product currently contains the following acceptable Confidential Statement of Formula (CSF):

x Basic CSF dated 06/26/2015 Any CSFs other than those listed above are superseded. If you have any questions, please contact Gina Burnett of my team by phone at (703) 605-0513 or via email at burnett.gina@epa.gov

. Sincerely,

Andrew Bryceland, Team Leader Biochemical Pesticides Branch Biopesticides and Pollution Prevention Division (7511P) Office of Pesticide Programs

EnclosureLEAP/Leap Page 1 of 9 LEAP® BIOLOGICAL INSECTICIDE EMULSIFIABLE SUSPENSION

Active Ingredient: Bacillus thuringiensis, subsp. kurstaki, strain ABTS-351, fermentation solids, spores, and insecticidal toxins........................................................................................................ 25.5% Methyl Salicylate.................................................................................... 5.9% Other Ingredients.............................................................................................................. ..68.6% Total.......................................................................................................................... .......100.0%
The percent active ingredient does not indicate product performance and the potency measurements are not Federally standardized.

KEEP OUT OF REACH OF CHILDREN 

### CAUTION

Valent BioSciences Corporation 870 Technology Way, Suite 100 Libertyville, IL 60048 List No. Lot No. EPA Reg. No. 73049- XXXX EPA Est. No. NET CONTENTS: 1 or 2.5 GALLONS 

## 09/25/2015

73049-500LEAP/Leap Page 2 of 9 FIRST AID

If on skin or clothing y Take off contaminate clothing.

y Rinse skin immediately with plenty of water for 15 - 20 minutes.

y Call a poison control center or doctor for treatment advice If in eyes y Hold eyes open and rinse slowly and gently with water for 15 - 20 minutes.

y Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye.

y Call a poison control center or doctor for treatment advice. Prolonged or frequently repeated skin contact may cause allergic reactions in some individuals
HOTLINE NUMBER Have the product container or label with you when calling a poison control center or doctor, or going for treatment. You may also contact 1-800-892-0099 (24 hours) for emergency medical treatment and/or transport emergency information. For all other information, call 1-800-6- Valent. NOTE TO PHYSICIAN Contains petroleum distillate - vomiting may cause aspiration pneumonia.
PRECAUTIONARY STATEMENTS HAZARDS TO HUMANS (AND DOMESTIC ANIMALS) CAUTION Avoid contact with skin, eyes or clothing. Wash thoroughly with soap and water after handling. Personal Protective Equipment Some materials that are chemical-resistant to this product are listed below. If you want more options, follow the instructions for category E on an EPA chemical resistance category selection chart. Applicators and other handlers must wear:

x Long-sleeved shirt and long pants.
x Chemical-resistant gloves, such as barrier laminate, or nitrile rubber, or neoprene rubber or viton.
x Shoes plus socks. Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables, use detergent and hot water. Keep and wash PPE separately from other laundry. Mixers/loaders and applicators must wear a dust/mist filtering respirator meeting NIOSH standards of at least N-95, R-95,or P-95. Repeated exposure to high concentrations of microbial proteins can cause allergic sensitization.LEAP/Leap Page 3 of 9 When handlers use closed systems, enclosed cabs, or aircraft in a manner that meets the requirements in the Worker Protections Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(4-6)], the handler PPE requirements may be reduced or modified as specified in the WPS. User Safety Recommendations Users should: • Wash hands before eating, drinking, chewing gum, using tobacco products or using the toilet. • Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. • Remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing.

ENVIRONMENTAL HAZARDS Do not apply directly to water, or to where surface water is present or to intertidal areas below the mean high water mark. Do not contaminate water when cleaning equipment or disposing of equipment washwaters. This product must not be applied aerially within 1⁄4 mile of any habitats of endangered species or threatened Lepidoptera. No manual application can be made within 300 feet of any threatened or endangered Lepidoptera.

DIRECTIONS FOR USE It is a violation of Federal law to use this product in a manner inconsistent with its labeling. For any requirements specific to your State or Tribe, consult the agency responsible for pesticide regulation.LEAP/Leap Page 4 of 9 AGRICULTURAL USE REQUIREMENTS Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR Part 170. This Standard contains requirements for the protection of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements for training, decontamination, notification, and emergency assistance. It also contains specific instructions and exceptions pertaining to the statements on this label about personal protective equipment (PPE), and restricted entry intervals. The requirements in this box only apply to uses of this product that are covered by the Worker Protection Standard. Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application. Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 12 hours. PPE required for early entry to treated areas that is permitted under the worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water is:

x Coveralls
x Chemical resistant gloves, such as barrier laminate or nitrile rubber or neoprene rubber or viton
x Shoes plus socks

NON-AGRICULTURAL USE REQUIREMENTS The requirements in this box apply to uses of this product that are NOT within the scope of the Worker Protection Standard for agricultural pesticides (40 CFR Part 170). The WPS applies when this product is used to produce agricultural plants on farms, forests, nurseries, or greenhouses. Do not enter treated areas without protective clothing until sprays have dried.

MODE OF ACTION Insecticide: After eating a lethal dose of LEAP®,Biologibal Insecticide, larvae stop feeding within the hour, and will die within several days. Dying larvae move slowly, discolor, then shrivel, blacken and die. Bacteriacide: LEAP® contains methyl salicylate, a known inducer of host plant resistance. Use of methyl salicylate in a preventative manner can trigger a defense response independent ofLEAP/Leap Page 5 of 9 infection, enhancing the plant’s ability to fight infection, thus preventing, or suppressing pathogen damage. LEAP may be used in either the field or greenhouse for the control of any labeled pest.

GENERAL INSTRUCTIONS LEAP is a highly selective insecticide for use against listed caterpillars (larvae) of Lepidopterous insects. Close scouting and early attention to infestations is highly recommended. Larvae must eat deposits of LEAP to be affected. Use of LEAP will also induce a systemic response in treated plants, enhancing the ability of the plant to resist disease infection and spread. Always follow these directions:

x Treat when larvae are young (early instars) and before economic thresholds of damage have been exceeded.

x Larvae must be actively feeding on treated, exposed plant parts.

x Thorough spray coverage is needed to provide a uniform deposit of LEAP where larvae feed and for maximal disease control. For some crops directed drop nozzles by ground machine are required. As crop matures and the canopy increases in size, increase water volume to ensure complete foliage coverage.

x Under heavy pest population pressure, use the higher label rates, shorten the spray interval, and/or increase spray volume to improve coverage.

x Repeat applications at an interval sufficient to maintain control, usually 5 to 14 days depending on plant growth rate, moth activity, rainfall after treating, and other factors. If attempting to control a pest with a single application, make the treatment when egg hatch is essentially complete, but before economic crop damage occurs.

x For bacterial pathogen suppression, LEAP must be used before the disease is observed in the field. For best results, use as part of a plant pathogen control program in rotation or tank mixed with other commercial bactericides and fungicides in a preventative manner. If disease is already present in the field, LEAP should be tank mixed with other registered funigicides or bactericides to ensure adequate control.

x LEAP is a non-restricted use pesticide and does not require a restricted use permit for purchase or use.

x LEAP may be tank mixed with other labeled insecticides and fungicides to enhance control. Use of the resulting tank mix must be in accordance with the more restrictive label limitations and precautions. No dosage rates should be exceeded. This product cannot beLEAP/Leap Page 6 of 9 mixed with any product containing a label prohibition against such mixing. Before tank mixing LEAP with other labeled products, including spreader stickers, check for tank mix compatibility.
Crop tolerance: Crop tolerance is acceptable for all crops on the label, however phytotoxic response has not been evaluated for all possible rotational and tank mix combinations under all conditions. When possible, test on a small section of crops to ensure no phytotoxicity will occur under your conditions. GROUND APPLICATIONS LEAP may be applied in ground equipment with quantities of water sufficient to provide thorough coverage of infested plant parts. The amount of water needed per acre will depend on crop development, weather, application equipment, and local experience. Do not spray when wind speed favors drift beyond the area intended for use. Avoiding spray drift at the application site is the responsibility of the applicator. The interaction of many equipment-and-weather-related factors determine the potential for spray drift. The applicator and the grower are responsible for considering all of these factors when making decisions. Mixing Recommendations: Important - do not add LEAP to the mix tank before introducing the desired quantity of water. Start the mechanical or hydraulic agitation to provide moderate circulation before adding LEAP. Add the desired volume of LEAP to the mix tank and continue circulation. Include rinse water from the container. Maintain the suspension while loading and spraying. Do not mix more LEAP than can be used in a 1-day period. Do not leave mixed material in the tank overnight. Rinse and flush spray equipment thoroughly following each use. Selection of fluid to flush the application system will depend on what type of mixture was used during the application period. Use a strainer no finer than 50 mesh in conventional spray systems. The physical compatibility of LEAP with other agricultural products should be evaluated before tank mixing for field use. Using a quart or larger jar, add the field proportional amounts of water volume and each product and mix well. If the materials remain mixed after 5-10 minutes, or can be re-mixed readily, then the materials are compatible for tank mixture.
CAUTION: LEAP should not be used in combination with Comite® , Bravo ® , Captafol, Captan (except seed) or Dyrene®

. Spray Volume Recommendations: For conventional ground application, use at least 20 gallons of volume per acre. Pests controlled by LEAPLEAP/Leap Page 7 of 9 Common name Scientific name Achema Sphinx Moth (Hornworm) Eumorpha achemon Armyworm Spodoptera spp., e.g. exigua, frugiperda, littoralis, Pseudaletia unipuncta Cherry Fruitworm Grapholita packardi Cotton Bollworm Helicoverpa zea Cranberry Fruitworm Acrobasis vaccinii Cross-striped Cabbageworm Evergestis rimosalis Cutworm Various Noctuid species, e.g. Agrotis ipsilon Diamondback Moth Plutella xylostella Ello Moth (Hornworm) Erinnyis ello Grape Berry Moth Paralobesia viteana Grape Leafroller Platynota stultana Grapeleaf Skeletonizer (ground only) Harrisina americana Green Cloverworm Plathypena scabra Gypsy Moth Lymantria dispar Headworm Helicoverpa zea Hornworm Manduca spp. Imported Cabbageworm Pieris rapae Looper Various Noctuidae, e.g. Trichoplusia ni Melonworm Diaphania hyalinata Obliquebanded Leafroller Choristoneura rosaceana Omnivorous Leafroller Playnota stultana Orange Tortrix Argyrotaenia citrana Podworm Heliocoverpa zea Rindworm complex Various Lepidoptera. Saltmarsh Caterpillar Estigmene acrea Soybean Looper Pseudoplusia includens Spanworm Ennomos subsignaria Tent Caterpillar Various Lasiocampidae Tobacco Budworm Heliothis virescens Tobacco Hornworm Manduca sexta Tobacco Moth Ephestia elutella Tomato Fruitworm Helicoverpa zea Variegated Cutworm Peridroma saucia Velvetbean Caterpillar Anticarsia gemmatalis Southern cornstalk borer Diatraea crambidoides Sugarcane borer Diatraea saccharalis Corn earworm, cotton bollworm, tomato fruitworm Helicoverpa zea
Tobacco budworm Heliothis virescensLEAP/Leap Page 8 of 9 

### APPLICATION RATE Field Crops Application rate (Pints/Acre) Applications may be made up to flowering stage Tomato Pepper, (bell) 1.0-4.0 LEAP may be used to control small armyworms and podworms when populations are light and full coverage sprays are applied.

For Xanthomonas spp. and Pseudomonas spp. pathogen suppression, apply preventatively on a 7-10 day schedule. Do not apply more frequently than every 5 days. Do not apply more than 16 pints per acre per season. For best disease control, LEAP should be used in tank mix or rotation with other registered pathogen control products, especially if disease is already observed in the crop.LEAP/Leap Page 9 of 9 For Small Spray Volumes: If Rate Is: Use This Amount Per Gallon 1/2 pt./acre or 100 gals. 1/2 tsp. 1 pt./acre or 100 gals 1 tsp. 2 pts./acre or 100 gals. 2 tsps. 4 pts./acre or 100 gals. 4 tsps.

STORAGE AND DISPOSAL Do not contaminate water, food or feed by storage or disposal. Storage: Keep containers tightly closed when not in use. Do not store at temperatures greater than 100° F. Roll or shake the container before dispensing. Pesticide Disposal: Wastes resulting from the use of this product may be disposed of on site or at an approved waste disposal facility. Do not contaminate water when disposing of equipment washwaters. Container Disposal: Nonrefillable container. Do not reuse this container. Triple rinse container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents into application equipment or a mix tank and drain for 10 seconds after the flow begins to drip. Fill the container 1⁄4 full with water and recap. Shake for 10 seconds. Pour rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. Repeat this procedure two more times. Once cleaned, some agricultural plastic pesticide containers can be taken to a container collection site or picked up for recycling. To find the nearest site, contact your chemical dealer or manufacturer, or contact Ag Container Recycling Council at 202-861-3144 or www.acrecycle.org. If recycling is not available puncture and dispose of the container in a sanitary landfill, or by other procedures approved by state and local authorities.

NOTICE TO USER Seller makes no warranty, express or implied, of merchantability, fitness or otherwise concerning use of this product other than as indicated on the label. User assumes all risks of use, storage or handling not in strict accordance with accompanying directions.

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