U.S. ENVIRONMENTAL PROTECTION AGENCY 

Office of Pesticide Programs 

Biopesticides and Pollution Prevention Division (7511P) 

1200 Pennsylvania Ave., N.W. 

Washington, D.C. 20460

EPA Reg. Number:

73049-500

Date of Issuance: 

9/25/2015

NOTICE OF PESTICIDE: 

 X Registration 

 Reregistration

Term of Issuance: 

Unconditional 

(under FIFRA, as amended)

Name of Pesticide Product:

Leap ® Biological Insecticide 

Emulsifiable Suspension 

Name and Address of Registrant (include ZIP Code):

Valent Biosciencies Corporation 

870 Technology Way, Suite 100 

Libertyville, IL 60048 

Note: Changes in labeling differing in substance from that accepted in connection with this registration must be submitted to and accepted by the 

Biopesticides and Pollution Prevention Division prior to use of the label in commerce. In any correspondence on this product, always refer to the above EPA 

Registration Number.

On the basis of information furnished by the registrant, the above named pesticide is hereby registered under the 

Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA or the Act). 

Registration is in no way to be construed as an endorsement or recommendation of this product by the U.S. 

Environmental Protection Agency (EPA). In order to protect health and the environment, the Administrator, on 

his or her motion, may at any time suspend or cancel the registration of a pesticide in accordance with the Act. 

The acceptance of any name in connection with the registration of a product under the Act is not to be construed 

as giving the registrant a right to exclusive use of the name or to its use if it has been covered by others. 

This product is unconditionally registered in accordance with FIFRA section 3(c)(5) provided that you: 

1. Submit and/or cite all data required for registration or registration review of your product when the EPA 

requires all registrants of similar products to submit such data. 

2. Submit storage stability and corrosion characteristics (Guidelines 830.6317 and 830.6320) data as these 

data requirements are not satisfied. A one-year study is required to satisfy these data requirements. You 

have 18 months from the date of this registration to provide these data to the EPA.

Signature of Approving Official:

Andrew Bryceland, Team Leader 

Biochemical Pesticides Branch 

Biopesticides and Pollution Prevention Division (7511P) 

Office of Pesticide Programs

Date: 

 9/25/2015

EPA Form 8570-6 
Page 2 of 2

EPA Reg. No. 73049-500 

OPP Decision No. 489428 

3. Make the following labeling change before you release this product for shipment:

x Revise the EPA Registration Number to read, “EPA Reg. No. 73049-500.”

4. Submit one (1) copy of the final printed labeling for the record before you release this product for

shipment.

Should you wish to add/retain a reference to your company’s website on your label, then please be aware that the 

website becomes labeling under FIFRA and is subject to review by the EPA. If the website is false or misleading, 

the product will be considered to be misbranded and sale or distribution of the product is unlawful under FIFRA 

section 12(a)(1)(E). 40 CFR § 156.10(a)(5) lists examples of statements the EPA may consider false or 

misleading. In addition, regardless of whether a website is referenced on your product’s label, claims made on the 

website may not substantially differ from those claims approved through the registration process. Therefore, 

should the EPA find or if it is brought to our attention that a website contains false or misleading statements or 

claims substantially differing from the EPA-approved registration, the website will be referred to the EPA’s 

Office of Enforcement and Compliance Assurance. 

Your release for shipment of this product constitutes acceptance of these terms. If these terms are not complied 

with, this registration will be subject to cancellation in accordance with FIFRA section 6. A stamped copy of the 

labeling is enclosed for your records. Please also note that the record for this product currently contains the 

following acceptable Confidential Statement of Formula (CSF): 

x Basic CSF dated 06/26/2015

Any CSFs other than those listed above are superseded. 

If you have any questions, please contact Gina Burnett of my team by phone at (703) 605-0513 or via email at 

burnett.gina@epa.gov.

Sincerely, 

Andrew Bryceland, Team Leader 

Biochemical Pesticides Branch 

Biopesticides and Pollution 

 Prevention Division (7511P) 

Office of Pesticide Programs 

Enclosure
LEAP/Leap 

Page 1 of 9

LEAP®

BIOLOGICAL INSECTICIDE 

EMULSIFIABLE SUSPENSION 

Active Ingredient: 

Bacillus thuringiensis, subsp. kurstaki, strain ABTS-351, fermentation solids, spores, 

and insecticidal toxins........................................................................................................25.5%

Methyl Salicylate.................................................................................... 5.9% 

Other Ingredients................................................................................................................68.6%

Total.................................................................................................................................100.0%

The percent active ingredient does not indicate product performance and the potency 

measurements are not Federally standardized. 

KEEP OUT OF REACH OF CHILDREN

CAUTION

Valent BioSciences Corporation 

870 Technology Way, Suite 100 

Libertyville, IL 60048 

List No. 

Lot No. 

EPA Reg. No. 73049- XXXX 

EPA Est. No.

NET CONTENTS: 1 or 2.5 GALLONS 

09/25/2015

73049-500
LEAP/Leap 

Page 2 of 9

FIRST AID

If on skin or 

clothing

y Take off contaminate clothing. 

y Rinse skin immediately with plenty of water for 15 - 20 minutes. 

y Call a poison control center or doctor for treatment advice 

If in eyes y Hold eyes open and rinse slowly and gently with water for 15 - 20 

minutes. 

y Remove contact lenses, if present, after the first 5 minutes, then 

continue rinsing eye. 

y Call a poison control center or doctor for treatment advice. 

Prolonged or frequently repeated skin contact may cause allergic reactions in some individuals 

HOTLINE NUMBER

Have the product container or label with you when calling a poison control center or doctor, or 

going for treatment. You may also contact 1-800-892-0099 (24 hours) for emergency medical 

treatment and/or transport emergency information. For all other information, call 1-800-6-

Valent.

NOTE TO PHYSICIAN

Contains petroleum distillate - vomiting may cause aspiration pneumonia. 

PRECAUTIONARY STATEMENTS

HAZARDS TO HUMANS (AND DOMESTIC ANIMALS) 

CAUTION

Avoid contact with skin, eyes or clothing. Wash thoroughly with soap and water after handling. 

Personal Protective Equipment

Some materials that are chemical-resistant to this product are listed below. If you want more 

options, follow the instructions for category E on an EPA chemical resistance category selection 

chart. 

Applicators and other handlers must wear: 

x Long-sleeved shirt and long pants.

x Chemical-resistant gloves, such as barrier laminate, or nitrile rubber, or neoprene rubber

or viton.

x Shoes plus socks.

Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for 

washables, use detergent and hot water. Keep and wash PPE separately from other laundry. 

Mixers/loaders and applicators must wear a dust/mist filtering respirator meeting NIOSH 

standards of at least N-95, R-95,or P-95. Repeated exposure to high concentrations of microbial 

proteins can cause allergic sensitization. 
LEAP/Leap 

Page 3 of 9

When handlers use closed systems, enclosed cabs, or aircraft in a manner that meets the 

requirements in the Worker Protections Standard (WPS) for agricultural pesticides [40 CFR 

170.240(d)(4-6)], the handler PPE requirements may be reduced or modified as specified in the 

WPS. 

User Safety Recommendations 

Users should: 

• Wash hands before eating, drinking, chewing gum, using tobacco products or using the

toilet. 

• Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and

put on clean clothing. 

• Remove PPE immediately after handling this product. Wash the outside of gloves

before removing. As soon as possible, wash thoroughly and change into clean clothing.

ENVIRONMENTAL HAZARDS

Do not apply directly to water, or to where surface water is present or to intertidal areas below 

the mean high water mark. Do not contaminate water when cleaning equipment or disposing of 

equipment washwaters. 

This product must not be applied aerially within 1⁄4 mile of any habitats of endangered species or 

threatened Lepidoptera. No manual application can be made within 300 feet of any threatened or 

endangered Lepidoptera.

DIRECTIONS FOR USE

It is a violation of Federal law to use this product in a manner inconsistent with its labeling. 

For any requirements specific to your State or Tribe, consult the agency responsible for pesticide 

regulation.
LEAP/Leap 

Page 4 of 9

AGRICULTURAL USE REQUIREMENTS

Use this product only in accordance with its labeling and with the Worker Protection 

Standard, 40 CFR Part 170. This Standard contains requirements for the protection of 

agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of 

agricultural pesticides. It contains requirements for training, decontamination, 

notification, and emergency assistance. It also contains specific instructions and 

exceptions pertaining to the statements on this label about personal protective equipment 

(PPE), and restricted entry intervals. The requirements in this box only apply to uses of 

this product that are covered by the Worker Protection Standard. 

Do not apply this product in a way that will contact workers or other persons, either 

directly or through drift. Only protected handlers may be in the area during application. 

Do not enter or allow worker entry into treated areas during the restricted entry interval 

(REI) of 12 hours. 

PPE required for early entry to treated areas that is permitted under the worker Protection 

Standard and that involves contact with anything that has been treated, such as plants, 

soil, or water is: 

x Coveralls

x Chemical resistant gloves, such as barrier laminate or nitrile rubber or neoprene

rubber or viton

x Shoes plus socks

NON-AGRICULTURAL USE REQUIREMENTS

The requirements in this box apply to uses of this product that are NOT within the scope 

of the Worker Protection Standard for agricultural pesticides (40 CFR Part 170). The 

WPS applies when this product is used to produce agricultural plants on farms, forests, 

nurseries, or greenhouses. 

Do not enter treated areas without protective clothing until sprays have dried.

MODE OF ACTION

Insecticide: After eating a lethal dose of LEAP®,Biologibal Insecticide, larvae stop feeding 

within the hour, and will die within several days. Dying larvae move slowly, discolor, then 

shrivel, blacken and die. 

Bacteriacide: LEAP® contains methyl salicylate, a known inducer of host plant resistance. Use 

of methyl salicylate in a preventative manner can trigger a defense response independent of 
LEAP/Leap 

Page 5 of 9

infection, enhancing the plant’s ability to fight infection, thus preventing, or suppressing 

pathogen damage. 

LEAP may be used in either the field or greenhouse for the control of any labeled pest. 

GENERAL INSTRUCTIONS

LEAP is a highly selective insecticide for use against listed caterpillars (larvae) of Lepidopterous 

insects. Close scouting and early attention to infestations is highly recommended. Larvae must 

eat deposits of LEAP to be affected. Use of LEAP will also induce a systemic response in 

treated plants, enhancing the ability of the plant to resist disease infection and spread. Always 

follow these directions: 

x Treat when larvae are young (early instars) and before economic thresholds of damage have

been exceeded.

x Larvae must be actively feeding on treated, exposed plant parts.

x Thorough spray coverage is needed to provide a uniform deposit of LEAP where larvae feed

and for maximal disease control. For some crops directed drop nozzles by ground machine

are required. As crop matures and the canopy increases in size, increase water volume to

ensure complete foliage coverage.

x Under heavy pest population pressure, use the higher label rates, shorten the spray interval,

and/or increase spray volume to improve coverage.

x Repeat applications at an interval sufficient to maintain control, usually 5 to 14 days

depending on plant growth rate, moth activity, rainfall after treating, and other factors. If

attempting to control a pest with a single application, make the treatment when egg hatch is

essentially complete, but before economic crop damage occurs.

x For bacterial pathogen suppression, LEAP must be used before the disease is observed in the

field. For best results, use as part of a plant pathogen control program in rotation or tank

mixed with other commercial bactericides and fungicides in a preventative manner. If disease

is already present in the field, LEAP should be tank mixed with other registered funigicides

or bactericides to ensure adequate control.

x LEAP is a non-restricted use pesticide and does not require a restricted use permit for

purchase or use.

x LEAP may be tank mixed with other labeled insecticides and fungicides to enhance control.

Use of the resulting tank mix must be in accordance with the more restrictive label

limitations and precautions. No dosage rates should be exceeded. This product cannot be
LEAP/Leap 

Page 6 of 9

mixed with any product containing a label prohibition against such mixing. Before tank 

mixing LEAP with other labeled products, including spreader stickers, check for tank mix 

compatibility. 

Crop tolerance: Crop tolerance is acceptable for all crops on the label, however phytotoxic 

response has not been evaluated for all possible rotational and tank mix combinations under all 

conditions. When possible, test on a small section of crops to ensure no phytotoxicity will occur 

under your conditions. 

GROUND APPLICATIONS

LEAP may be applied in ground equipment with quantities of water sufficient to provide 

thorough coverage of infested plant parts. The amount of water needed per acre will depend on 

crop development, weather, application equipment, and local experience. 

Do not spray when wind speed favors drift beyond the area intended for use. 

Avoiding spray drift at the application site is the responsibility of the applicator. The interaction 

of many equipment-and-weather-related factors determine the potential for spray drift. The 

applicator and the grower are responsible for considering all of these factors when making 

decisions.

Mixing Recommendations: Important - do not add LEAP to the mix tank before introducing 

the desired quantity of water. Start the mechanical or hydraulic agitation to provide moderate 

circulation before adding LEAP. Add the desired volume of LEAP to the mix tank and continue 

circulation. Include rinse water from the container. Maintain the suspension while loading and 

spraying. Do not mix more LEAP than can be used in a 1-day period. Do not leave mixed 

material in the tank overnight. Rinse and flush spray equipment thoroughly following each use. 

Selection of fluid to flush the application system will depend on what type of mixture was used 

during the application period. Use a strainer no finer than 50 mesh in conventional spray 

systems. 

The physical compatibility of LEAP with other agricultural products should be evaluated before 

tank mixing for field use. Using a quart or larger jar, add the field proportional amounts of water 

volume and each product and mix well. If the materials remain mixed after 5-10 minutes, or can 

be re-mixed readily, then the materials are compatible for tank mixture. 

CAUTION:

LEAP should not be used in combination with Comite®, Bravo®, Captafol, Captan (except seed) 

or Dyrene®.

Spray Volume Recommendations: For conventional ground application, use at least 20 gallons 

of volume per acre. 

Pests controlled by LEAP 
LEAP/Leap 

Page 7 of 9

Common name Scientific name 

Achema Sphinx Moth (Hornworm) Eumorpha achemon 

Armyworm Spodoptera spp., e.g. exigua, frugiperda, 

littoralis, Pseudaletia unipuncta 

Cherry Fruitworm Grapholita packardi 

Cotton Bollworm Helicoverpa zea 

Cranberry Fruitworm Acrobasis vaccinii 

Cross-striped Cabbageworm Evergestis rimosalis 

Cutworm Various Noctuid species, e.g. Agrotis ipsilon 

Diamondback Moth Plutella xylostella 

Ello Moth (Hornworm) Erinnyis ello 

Grape Berry Moth Paralobesia viteana 

Grape Leafroller Platynota stultana 

Grapeleaf Skeletonizer (ground only) Harrisina americana 

Green Cloverworm Plathypena scabra 

Gypsy Moth Lymantria dispar 

Headworm Helicoverpa zea 

Hornworm Manduca spp. 

Imported Cabbageworm Pieris rapae 

Looper Various Noctuidae, e.g. Trichoplusia ni 

Melonworm Diaphania hyalinata 

Obliquebanded Leafroller Choristoneura rosaceana 

Omnivorous Leafroller Playnota stultana 

Orange Tortrix Argyrotaenia citrana 

Podworm Heliocoverpa zea 

Rindworm complex Various Lepidoptera. 

Saltmarsh Caterpillar Estigmene acrea 

Soybean Looper Pseudoplusia includens 

Spanworm Ennomos subsignaria 

Tent Caterpillar Various Lasiocampidae 

Tobacco Budworm Heliothis virescens 

Tobacco Hornworm Manduca sexta 

Tobacco Moth Ephestia elutella 

Tomato Fruitworm Helicoverpa zea 

Variegated Cutworm Peridroma saucia 

Velvetbean Caterpillar Anticarsia gemmatalis 

Southern cornstalk borer Diatraea crambidoides 

Sugarcane borer Diatraea saccharalis 

Corn earworm, cotton bollworm, tomato 

fruitworm

Helicoverpa zea 

Tobacco budworm Heliothis virescens 
LEAP/Leap 

Page 8 of 9

APPLICATION RATE

Field Crops Application rate 

(Pints/Acre) 

Applications may be made up to flowering stage 

Tomato 

Pepper, (bell) 

1.0-4.0

LEAP may be used to control small 

armyworms and podworms when 

populations are light and full 

coverage sprays are applied. 

For Xanthomonas spp. and 

Pseudomonas spp. pathogen 

suppression, apply preventatively on 

a 7-10 day schedule. Do not apply 

more frequently than every 5 days.

Do not apply more than 16 pints per 

acre per season. For best disease 

control, LEAP should be used in 

tank mix or rotation with other 

registered pathogen control 

products, especially if disease is 

already observed in the crop.
LEAP/Leap 

Page 9 of 9

For Small Spray Volumes:

If Rate Is: Use This Amount Per Gallon 

1/2 pt./acre or 100 gals. 1/2 tsp. 

1 pt./acre or 100 gals 1 tsp. 

2 pts./acre or 100 gals. 2 tsps. 

4 pts./acre or 100 gals. 4 tsps. 

STORAGE AND DISPOSAL

Do not contaminate water, food or feed by storage or disposal. 

Storage: Keep containers tightly closed when not in use. Do not store at temperatures greater 

than 100° F. Roll or shake the container before dispensing. 

Pesticide Disposal: Wastes resulting from the use of this product may be disposed of on site or 

at an approved waste disposal facility. Do not contaminate water when disposing of equipment 

washwaters.

Container Disposal: Nonrefillable container. Do not reuse this container.

Triple rinse container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the 

remaining contents into application equipment or a mix tank and drain for 10 seconds after the 

flow begins to drip. Fill the container 1⁄4 full with water and recap. Shake for 10 seconds. Pour 

rinsate into application equipment or a mix tank or store rinsate for later use or disposal. Drain 

for 10 seconds after the flow begins to drip. Repeat this procedure two more times. 

Once cleaned, some agricultural plastic pesticide containers can be taken to a container 

collection site or picked up for recycling. To find the nearest site, contact your chemical dealer or 

manufacturer, or contact Ag Container Recycling Council at 202-861-3144 or 

www.acrecycle.org . If recycling is not available puncture and dispose of the container in a 

sanitary landfill, or by other procedures approved by state and local authorities. 

NOTICE TO USER

Seller makes no warranty, express or implied, of merchantability, fitness or otherwise concerning 

use of this product other than as indicated on the label. User assumes all risks of use, storage or 

handling not in strict accordance with accompanying directions. 

©2014