1

Appendix D. Citations Considered to be Part of the Data Base Supporting the 

Reregistration Eligibility Decision of Pyrethrins

MRID# Study

42010901 Campbell, S.; Lynn, S. (1991) An Acute Oral Toxicity Study with Pyrethrum Extract in the Northern 

Bobwhite Quail: Lab Project Number: 326-103. Unpublished study prepared by Wildlife International Ltd. 

40 p. 

41968801 Grimes, J.; Lynn, S.; Smith, G. (1991) A Dietary LC50 Study with Pyrethrum Extract in the Northern 

Bobwhite Quail: Lab Project Number: 326-101. Unpublished study prepared by Wildlife Inter- national Ltd. 

62 p. 

41968802 Grimes, J.; Lynn, S.; Smith, G. (1991) A Dietary LC50 Study with Pyrethrum Extract in the Mallard: Lab 

Project Number: 326/102. Unpublished study prepared by Wildlife International Ltd. 62 p. 

43082301 Machado, M. (1994) Pyrethrum Extract (FEK-99): A Flow-Through Acute Toxicity Test with Bluegill 

Sunfish (Lepomis macrochirus): Final Report: Lab Project Number: 93/8/4916. Unpublished study prepared 

by Springborn Laboratories, Inc. 66 p. 

43082302 Machado, M. (1994) Pyrenone Crop Spray (Sample Ref. 13650): A Flow-Through Acute Toxicity Test with 

Bluegill Sunfish (Lepomis macrochirus): Final Report: Lab Report Number 93/11/5008. Unpublished study 

prepared by Springborn Laboratories, Inc. 66 p. 

43082303 Machado, M. (1994) Pyrethrum Extract (FEK-99): A Flow-Through Acute Toxicity Test with Rainbow 

Trout (Oncorhynchus mykiss): Final Report: Lab Project Number: 93/11/5084. Unpublished study prepared 

by Springborn Laboratories, Inc. 65 p. 

43082304 Machado, M. (1994) Pyrenone Crop Spray (Sample Ref. 13650): A Flow-Through Acute Toxicity Test with 

Rainbow Trout (Oncorhynchus mykiss): Final Report: Lab Project Number: 93/11/5048. Unpublished study 

prepared by Springborn Laboratories, Inc. 65 p. 

43082305 Putt, A. (1994) Pyrethrum Extract (FEK-99): A Acute Toxicity to Daphnids (Daphnia magna) under FlowThrough Conditions: Final Report: Lab Project Number: 93/11/5082. Unpublished study prepared by 

Springborn Laboratories, Inc. 71 p 

43082306 Putt, A. (1994) Pyrenone Crop Spray (Sample Ref. 13650): Acute Toxicity to Daphnids (Daphnia magna) 

under Flow-Through Conditions: Final Report: Lab Project Number: 93/11/5075. Unpublished study 

prepared by Springborn Laboratories, Inc. 82 p. 

43082307 Machado, M. (1994) Pyrethrum Extract (FEK-99): A Flow-Through Acute Toxicity Test with Sheepshead 

Minnow (Cyprinodon variegatus): Final Report: Lab Project Number: 93/12/5081. Unpublished study 

prepared by Springborn Laboratories, Inc. 64 p. 

43082309 Dionne E. (1994) Pyrethrum Extract (FEK-99): Acute Toxicity to Eastern Oyster (Crassostrea virginica) 

under Flow-Through Conditions: Final Report: Lab Project Number: 93/11/5032. Unpublished study 

prepared by Springborn Laboratories, Inc. 65 p. 

43082311 Machado, M. (1994) Pyrethrum Extract (FEK-99): Acute Toxicity to Mysid Shrimp (Mysidopsis bahia) 

under Flow-Through Conditions: Final Report: Lab Project Number: 93/12/5097. Unpublished study 

prepared by Springborn Laboratories, Inc. 68 p. 

43082308 Machado, M. (1994) Pyrenone Crop Spray (Sample Ref. 13650): A Flow-Through Acute Toxicity Test with 

Sheepshead Minnow (Cyprinodon variegatus): Final Report: Lab Project Number: 93/11/5037. Unpublished 

study prepared by Springborn Laboratories, Inc. 63 p. 

43082310 Dionne E. (1994) Pyrenone Crop Spray (Sample Ref. 13650): Acute Toxicity to Eastern Oyster (Crassostrea 

virginica) under Flow-Through Conditions: Final Report: Lab Project Number: 93/10/4995. Unpublished 

study prepared by Springborn Laboratories, Inc. 67 p. 

43082312 Machado, M. (1994) Pyrenone Crop Spray (Sample Ref. 13650): Acute Toxicity to Mysid Shrimp 

(Mysidopsis bahia) under Flow-Through Conditions: Final Report: Lab Project Number: 93/12/5077. 

Unpublished study prepared by Springborn Laboratories, Inc. 67 p. 
2

MRID# Study

43252701 Machado, M. (1994) Pyrethrum Extract (FEK-99)-The Toxicity to Fathead Minnow (Pimephales promelas) 

During an Early Life-Stage Exposure: Final Report: Lab Project Number: 93-10-4983: 11572. 0193. 6114. 

120. Unpublished study prepared by Springborn Lab., Inc. 137 p. 

43252702 Putt, A. (1994) Pyrethrum Extract (FEK-99)-The Chronic Toxicity to Daphnia magna Under Flow-Through 

Conditions: Final Report: Lab Project Number: 94-1-5116: 11572.0193.6115.130. Unpublished study 

prepared by Springborn Lab., Inc. 165 p. 

42599501 Gabriel, D. (1992) Acute Oral Toxicity, LD50--Rats: Pyrethrum Extract: Lab Project Number: 92-7529A. 

Unpublished study prepared by Biosearch Inc. 109 p. 

42008101 Gabriel, D. (1991) Acute Oral Toxicity LD50--Rats: Pyrethrum Extract: Lab Project Number: 91-7316A. 

Unpublished study prepa- red by Biosearch Inc. 82 p. 

41964801 Gabriel, D. (1991) Pyrethrum Extract: Acute Dermal Toxicity, Single Level--Rabbits: Lab Project Number: 

91-7316A. Unpublished study prepared by Biosearch Inc. 40 p. 

42008001 Hoffman, G. (1991) An Acute Inhalation Toxicity Study of Pyrethrum Extract in the Rat: Final Report: Lab 

Project Number: 91-8331. Unpublished study prepared by Bio/dyanmics, Inc. 143 p.

41964802 Bielucke, J. (1991) Pyrethrum Extract: Primary Eye Irritation--Rabbits: Lab Project Number: 91-7316A. 

Unpublished study prepared by Biosearch Inc. 30 p. 

41964803 Extract, P. (1991) Pyrethrum Extract: Primary Skin Irritation-- Rabbits: Lab Project Number: 91-7316A. 

Unpublished study prepared by Biosearch Inc. 23 p. 

41964804 Romanelli, P. (1991) Pyrethrum Extract: Guinea Pig Dermal Sensitization--Modified Buehler Method: Lab 

Project Number: 91-7316A. Unpublished study prepared by Biosearch Inc. 61 p.

42925801 Hermansky, S.; Hurley, J. (1993) Acute Oral Neurotoxicity Study with Pyrethrum Extract in Rats: Lab 

Project Number: 92N1036. Unpublished study prepared by Union Carbide Chemicals and Plastics Co., Inc., 

Bushy Run Research Center. 393 p.

42930401 Hermansky, S.; Hurley, J. (1993) Peroral (Gavage) Neurotoxicity Probe Study with Pyrethrum Extract in 

CD Rats: Lab Project Number: 91N0122. Unpublished study prepared by Union Carbide, Bushy Run 

Research Center (BRRC). 84 p. 

43785301 Van Miller, J. (1995) Peroral (Gavage) Neurotoxicity Probe Study With Pyrethrum Extract in CD Rats: 

Amended Report: Lab Project Number: 91N0122. Unpublished study prepared by Union Carbide (Bushy 

Run Research Center). 4 p.

43785302 Van Miller, J. (1995) Acute Oral Neurotoxicity Study With Pyrethrum Extract in Rats: Amended Report: 

Lab Project Number: 92N1036. Unpublished study prepared by Union Carbide (Bushy Run Research 

Center). 4 p.

42212601 Goldenthal, E. (1992) 21-Day Repeated Dose Dermal Toxicity Study with Pyrethrum Extract in Rabbits: 

Lab Project Number: 556-018. Unpublished study prepared by International Research and Development 

Corp. 247 p.

42478201 Newton, P. (1992) A Subchronic (3-Month) Inhalation Toxicity Study of Pyrethrum Extract in the Rat Via 

Whole-body Exposures: Final Report: Lab Project Number: 91-8335. Unpublished study prepared by 

Bio/dynamics Inc. 870 p.

42328701 Engel, R. (1992) Letter sent to Office of Pesticide Programs dated 5/26/92 concerning findings in a 90-day

inhalation study with Pyrethrum Extract.Prepared by Chem. Specialties Manuf. Assoc. for Pyrethrin Joint 

Venture. 13 p. 

41559501 Goldenthal, E. (1990) Evaluation of Pyrethrum Extract in a Two Year Dietary Toxicity and Oncogenicity 

Study in Rats: Lab Project No. 556-011. Unpublished study prepared by Internation- al Research and 

Development Corp. 2002 p.
3

MRID# Study

43811301 Schoenig, G. (1995) Addendum to the Response to EPA Data Evaluation Record for Study Entitled: 

Evaluation of Pyrethrum Extract in a Two-Year Dietary Toxicity and Oncogenicity Study in Rats: Lab 

Project Number: 556-011. Unpublished study prepared by International Research and Development Corp. 

13 p.

43567701 Schoenig, G. (1995) Response to EPA Data Evaluation Record for Study Entitled: Evaluation of Pyrethrum 

Extract in a Two-Year Dietary Toxicity and Oncogenicity Study in Rats: Lab Project Number: 56-011. 

Unpublished study prepared by International Research and Development Corp. 186 p.

41496501 Goldenthal, E. (1990) Evaluation of Pyrethrum Extract in a One Year Chronic Toxicity Study in Dogs: Lab 

Project Number: 556-007. Un- published study prepared by International Research and Develop- ment Corp. 

331 p.

46605701 Osimitz, T.; Droege, W. (2005) A Review of the Toxicoligical Significance of Cellular Changes in the 

Larynx in the Rat: Pyrethrins. Unpublished study prepared by Science Strategies. 41 p.

45889801 Finch, J.; Martin, T.; Travers, K.; et al. (2002) Pyrethrins: 28 Day Dose Range Finding Study in Female 

Rats with Administration by the Diet: Lab Project Number: 19422: 455324. Unpublished study prepared by 

Inveresk Research Group. 105 p.

45889802 Finch, J.; Martin, T.; Travers, K.; et al. (2002) Definitive Mechanistic Toxicity Study in Rats with 

Pyrethrins: Lab Project Number: 21029: 455790. Unpublished study prepared by Inveresk Research. 578 p. 

45889803 Lake, B. (2002) An Investigation of Some Hepatic Enzyme Activities in Liver Samples Derived from 

Inveresk Study 455790: Definitive Mechanistic Toxicity Study in Rats with Pyrethrins: Final Report: Lab 

Project Number: 4024/2: 4024/2/2/2002. Unpublished study prepared by TNO BIBRA International Ltd. 

214 p.

45889804 Osimitz, T. (2002) Overview of Mode of Action Studies on Pyrethrins. Unpublished study prepared by 

Pyrethrin Joint Venture. 15 p.

43811301 Schoenig, G. (1995) Addendum to the Response to EPA Data Evaluation Record for Study Entitled: 

Evaluation of Pyrethrum Extract in a Two-Year Dietary Toxicity and Oncogenicity Study in Rats: Lab 

Project Number: 556-011. Unpublished study prepared by International Research and Development Corp. 

13 p.

43567701 Schoenig, G. (1995) Response to EPA Data Evaluation Record for Study Entitled: Evaluation of Pyrethrum 

Extract in a Two-Year Dietary Toxicity and Oncogenicity Study in Rats: Lab Project Number: 56-011. 

Unpublished study prepared by International Research and Development Corp. 186 p.

41559501 Goldenthal, E. (1990) Evaluation of Pyrethrum Extract in a Two Year Dietary Toxicity and Oncogenicity 

Study in Rats: Lab Project No. 556-011. Unpublished study prepared by Internation- al Research and 

Development Corp. 2002 p.

44223501 Burin, G.; Harvey, P. (1997) Assessment of New Information Relevant to the Carcinogenic Potential of 

Pyrethrins. Unpublished study prepared by Technology Sciences Group, Inc. and AgrEvo UK Ltd. 141 p.

44113001 Pyrethrin Joint Venture (1996) Response to June 12, 1995 EPA Carcinogenicity Peer Review Committee 

Review of Pyrethrins: Lab Project Number: PJV RESPONSE TO EPA: TO EPA-CPRC 6/12/95: 556-011. 

Unpublished study. 864 p.

43889701 Harvey, P. (1995) Pyrethrum: Lung Tumor Rebuttal. Unpublished study prepared by Chemical Speciality 

Manufacturers Assoc. 7 p.

43585201 Goldenthal, E. (1988) Evaluation of Pyrethrum Extract in a 13-Week Dose Range Finding Study (in Mice): 

Lab Project Number: 556-008. Unpublished study prepared by International Research and Development 

Corp. 243 p.
4

MRID# Study

43567702 Schoenig, G. (1995) Response to EPA Data Evaluation Record for Study Entitled: Evaluation of Pyrethrum 

Extract in an 18 Month Dietary Oncogenicity Study in Mice: Lab Project Number: 556-13. Unpublished 

study prepared by International Research and Development Corp. 40 p.

41559401 Goldenthal, E. (1990) Evaluation of Pyrethrum Extract in an Eighteen Month Dietary Oncogenicity Study in 

Mice: Lab Project Number 556-013. Unpublished study prepared by International Research & Development 

Co. 1471 p.

40288202 Schardein, J. (1987) Evaluation of Pyrethrum Extract in a Defini- tive Rat Teratology Study: Lab Project 

ID: IRDC 556-002. Unpublished study prepared by International Research and Devel- opment Corp. 76 p.

40603701 Schardein, J. (1987) Range-finding Teratology Study in Rats with Pyrethrum Extract: Laboratory Project ID 

556-001. Unpublished study prepared by International Research and Development Corp. 41 p.

40603702 Schardein, J. (1987) Range-finding Teratology Study in Rabbits with Pyrethrum Extract: Laboratory Project 

ID 556-003. Unpublished study prepared by International Research and Development Corp. 43 p.

40288203 Schardein, J. (1987) Evaluation of Pyrethrum Extract in a Definitive Rabbit Teratology Study: Lab Project 

ID: 556-004. Unpub- lished study prepared by International Research and Development Corp. 78 p.

41327501 Schardein, J. (1989) Two Generation Reproduction Study in Rats with Pyrethrum Extract: Lab Project 

Number: 556/005. Unpub- lished study prepared by International Research and Development Corp. 547 p. 

41344701 San, R.; Springfield, K. (1989) Salmonella/Mammalian-microsome Plate Incorporation Mutagenicity Assay 

(Ames Test) with a Confirmatory Assay: Lab Project Number: T8729.501014. Unpublish- ed study prepared 

by Microbiological Associates, Inc. 69 p.

43987001 Curry, P. (1996) Chromosome Aberrations in Chinese Hamster Ovary (CHO) Cells: Pyrethrum Extract, 

Blend FEK-99: Final Report: Lab Project Number: G96AC14.330001: 8004. Unpublished study prepared 

by Microbiological Associates, Inc. 61 p.

41344601 Putman, D.; Morris, M. (1989) Chromosome Abberations in Chinese Hamster Ovary (CHO) Cells: 

Pyrethrum Extract; Blend FEK-99: Lab Project Number: T8729/337. Unpublished study prepared by Microbiological Associates Inc. 34 p.

41344501 Curren, R. (1989) Unscheduled DNA Synthesis Assay in Rat Primary Hepatocytes with a Confirmatory 

Assay: Pyrethrum Extract Blend FEK-99: Final Report: Lab Project Number: T8729/380009. Unpub- lished 

study prepared by Microbiological Associates, Inc. 43 p.

43566301 Limoges, Jeannine. (1994) Determination of the Metabolic Profile of 14C-Pyrethrin 1 in Rats When 

Administered in Four Different Dosing Formulations" in support of the Study titled Pharmacokinetics and 

Metabolism of Pyrethrin I in the Rat. Unpublished study prepared by Biological Test Center. 136 p.

43884101 Selim, S. (1995) Determination of Expired 14C O2 Following a Single Oral Dose of Pyrethrin I in the Rat , 

Biological Test Center.

43554304 Selim, S. (1995) Pharmacokinetics and Metabolism of 14C Pyrethrin I in the Rat. BTC Study No. 

P1092006. Unpublished study prepared by Biological Test Center. 496 p.

43554305 Casida, J.; (1995) Opinion letter on PY 1 Metabolism in Rats.

42846901 Dimmenna, G.; Schoenig, G. (1993) Review of the Mammalian Metabolism of the Natural Pyrethrins. 

Unpublished study prepared by Toxicology/Regulatory Services, Inc. 39 p.

42939601 Engel, R. (1993) Commentary on Agency Letter dated March 17, 1993: re: Review of General Metabolism 

Study. Unpublished study prepared by CSMA for the Pyrethrin Joint Venture. 11 p. 
5

MRID# Study

41248801 Class, T.; Ando,T.; Casida, J. (1989) Pyrethroid Metabolism; Microsomal Oxidase Metabolites of (S) -

Bioallethrin and the Six Natural Pyrethrins. Project No. (none) Unpublished report prepared by Pesticide 

Chemistry and Toxicology Laboratory. 

41968803 Lynn, S.; Hoxter, K. (1991) An Acute Contact Toxicity Study with Pyrethrum Extract with the Honey Bee: 

Lab Project No: 326/104. Unpublished study prepared by Wildlife International Ltd. 33 p. 

40700401 Reddy, G. (1988) Analytical Results of Pyrethrin Photolysis Resi- dues after Exposure to Natural Sunlight: 

SL# 15981-15982. Un- published study prepared by Shrader Laboratories. 96 p.

43567502 Selim, S. (1995) Hydrolysis of Pyrethrin 1 as a Function of pH at 25 (degrees) C: Amended Report: Lab 

Project Numbers: P1092011: 93-1147.BTC. Unpublished study prepared by Biological Test Center. 163 p. 

43188201 Selim, S. (1994) Hydrolysis of Pyrethrin 1 as a Function of pH at 25 degrees C: Lab Project Number: 

P1092011: 93-1147.BTC. Unpublished study prepared by Biological Test Center. 83 p. 

43567601 Schoenig, G. (1995) Response to EPA Data Evaluation Record for Study Entitled: Aqueous Photolysis of 

Pyrethrin 1: Lab Project Number: P1192006. Unpublished study prepared by Biological Test Center. 6 p. 

43096601 Selim, S. (1994) Aqueous Photolysis of Pyrethrin 1: Lab Project Number: P1192006. Unpublished study 

prepared by Biological Test Center. 87 p. 

43096602 Testman, R. (1994) Soil Surface Photolysis of Pyrethrin 1: Lab Project Number: P1192007. Unpublished 

study prepared by Biological Test Center. 91 p. 

43499803 Robinson, R. (1994) Aerobic Soil Metabolism of (carbon 14)Pyrethrin 1: Lab Project Number: XBL93061: 

RPT00204. Unpublished study prepared by Xenobiotic Lab., Inc. 170 p. 

43499801 Robinson, R.; Wisocky, M. (1994) Anaerobic Aquatic Metabolism of (carbon 14)Pyrethrin 1: Lab Project 

Number: XBL93062: RPT00205. Unpublished study prepared by Xenobiotic Lab., Inc. 167 p. 

43499802 Robinson, R.; Wisocky, M. (1994) Aerobic Aquatic Metabolism of (carbon 14)Pyrethrin 1: Lab Project 

Number: XBL93063: RPT00193. Unpublished study prepared by Xenobiotic Lab., Inc. 130 p. 

43096603 Reynolds, J.; Robinson, R. (1994) Adsorption and Desorption of (carbon 14) Pyrethrin 1 in Four Soils: Lab 

Project Number: 93064: RPT00156. Unpublished study prepared by XenoBiotic Laboratories, Inc. 123 p. 

43096604 Selim, S. (1994) Laboratory Volatility of Pyrethrin 1 from Soil: Lab Project Number: P0693011. 

Unpublished study prepared by Biological Test Center. 101 p. 

42745501 Hattermann, D. (1992) LX1180-02 (Pyrethrum + Piperonyl Butoxide) Field Dissipation-Terrestrial Study on 

Bareground in California, Georgia, and Michigan: Lab Project Number: 91189: 18021E08. Unpublished 

study prepared by Bio/Dynamics, Inc. 207 p. 

43807101 Brookman, D.; Curry, K.; Smith, C. (1995) Data Waiver Request for the Requirement of a Study on 

Terrestrial Field Dissipation for Degradates of Pyrethrin. Unpublished study prepared by Technology 

Sciences Group, Inc. 28 p. 

43818501 Brookman, D.; Curry, K.; Hobson, J.; et al. (1995) Data Waiver Request for the Requirement of a Study on 

Aquatic Field Dissipation of Pyrethrin. Unpublished study prepared by Technology Sciences Group, Inc. 34 

p. 

43195201 Hattermann, D. (1994) Pyrethrin Analytical Phase for Pyrenone Crop Spray (Pyrethrin + Piperonyl 

Butoxide) Aquatic Dissipation Study Applied Post-Emergence to Barewater in California, Arkansas, and 

Mississippi: Lab Project Number: 18021V09: 91190: BD-047-92. Unpublished study prepared by 

Pharmaco LSR International, Inc. and Landis International, Inc. 152 p 

43302301 Schocken, M. (1994) Bioconcentration Study with (carbon 14) Pyrethrin 1 in Bluegill Sunfish: Final Report: 

Lab Project Number: 94-5-5258: 11572.0993.6125.140. Unpublished study prepared by Springborn Labs., 

Inc. 148 p. 
6

MRID# Study

43884102 St. Laurent, J. (1995) Development and Validation of an Analytical Methodology for the Determination of 

Total Pyrethrins in Water, Acetone, and Fish Tissue: Final Report: Lab Project Number: 93-9-4922: 

11572.0193.6105.250. Unpublished study prepared by Springborn Labs, Inc. 87 p. 

40700401 Reddy, G. (1988) Analytical Results of Pyrethrin Photolysis Resi- dues after Exposure to Natural Sunlight: 

SL# 15981-15982. Un- published study prepared by Shrader Laboratories. 96 p.

45900802 Singer, S.; Curry, K.; Brookman, D. (2003) Response to Chemistry and Exposure Branch Review Dated 

May 20, 1999 Regarding the Nature of Pyrethrin (PY) Residues in Plants and Animals: Lab Project 

Number: 68-D4-0010. Unpublished study prepared by Biological Test Center. 132 p. 

43668001 Selim, S. (1995) Nature of (carbon 14)-Pyrethrin 1 (PY 1) Residues in Leaf Lettuce: Amended Report: Lab 

Project Number: P0193016: 94-1215.BTC. Unpublished study prepared by Biological Test Center. 296 p. 

43628401 Selim, S. (1995) Nature of (Carbon-14) Pyrethrin 1 (PY 1) Residues in Potato: Amended Report: Lab 

Project Number: P0193017: 94-1167.BTC. Unpublished study prepared by Biological Test Center. 368 p. 

43628402 Selim, S. (1995) Nature of (Carbon-14) Pyrethrin 1 (PY1) Residues in Tomato: Amended Report: Lab 

Project Number: P0193018: 94-1225.BTC. Unpublished study prepared by Biological Test Center. 360 p. 

43554301 Selim, S. (1995) Nature of the (carbon 14)-Pyrethrin 1 (PY 1) Residues in Potato: Lab Project Number: 

P0193017: 94-1167.BTC. Unpublished study prepared by Biological Test Center. 155 p. 

43554302 Selim, S. (1995) Nature of the (carbon 14)-Pyrethrin 1 (PY 1) Residues in Tomato: Lab Project Number: 

P0193018: 94-1225.BTC. Unpublished study prepared by Biological Test Center. 161 p. 

43554303 Selim, S. (1995) Nature of the (carbon 14)-Pyrethrin 1 (PY 1) Residues in Leaf Lettuce: Lab Project 

Number: P0193016: 94-1215.BTC. Unpublished study prepared by Biological Test Center. 165 p. 

45900802 Singer, S.; Curry, K.; Brookman, D. (2003) Response to Chemistry and Exposure Branch Review Dated 

May 20, 1999 Regarding the Nature of Pyrethrin (PY) Residues in Plants and Animals: Lab Project 

Number: 68-D4-0010. Unpublished study prepared by Biological Test Center. 132 p. 

43837601 Selim, S. (1995) Metabolism Study of Pyrethrin 1 in Lactating Goat Following Oral or Dermal 

Adminstration: (Amended Report): Lab Project Number: P0494014: 95-0380.BTC. Unpublished study 

prepared by Biological Test Center. 421 p. 

43837602 Selim, S. (1995) Metabolism Study of Pyrethrin 1 in Laying Hens Following Oral or Dermal 

Administration: (Amended Report): Lab Project Number: P0494015: 95-0400.BTC. Unpublished study 

prepared by Biological Test Center. 396 p. 

43628301 Selim, S. (1995) Metabolism Study of Pyrethrin 1 in Lactating Goat Following Oral or Dermal 

Administration: Lab Project Number: P0494014: 95-0380.BTC. Unpublished study prepared by Biological 

Test Center. 413 p. 

43628302 Selim, S. (1995) Metabolism Study of Pyrethrin 1 in Laying Hens Following Oral or Dermal 

Administration: Lab Project Number: P0494015: 95-0400.BTC. Unpublished study prepared by Biological 

Test Center. 387 p. 

43833403 Hatton, C.; Baker, F. (1995) Identification of ((carbon 14)-Acid) Pyrethrin I Metabolite in Goat Fat and Hen 

Liver and Egg Yolk: Lab Project Number: 555W: 555W-1. Unpublished study prepared by PTRL West, Inc. 

95 p. 

PAM Vol 

II

Res. analyt. method
7

MRID# Study

45256501 Hattermann, D. (2000) Amended Field and Processing Phases for LX1180-02 (Pyrethrin + Piperonyl 

Butoxide) Processed Commodity Trial on Potatoes in Washington: Lab Project Number: 18008D022. 

Unpublished study prepared by Landis International, Inc. 220 p. 

45037102 Hatterman, D. (1999) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Tomatoes: Lab Project 

Number: 18015B006: 1714-91-180-02-15B52. Unpublished study prepared by Landis International, Inc. 

and Agvise, Inc. 371 p. 

45037103 Hatterman, D. (1999) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Oranges: Lab Project 

Number: 18001B015: 1714-91-180-02-01B93: 93-0076. Unpublished study prepared by Landis 

International, Inc. and Agvise, Inc. 339 p. 

45037104 Hatterman, D. (1999) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Grapes: Lab Project 

Number: 18003B019: 1714-92-180-02-03B03: BD-007-93. Unpublished study prepared by Landis 

International, Inc. and Agvise, Inc. 319 p. 

44140401 Winkler, D.; Huff, D. (1996) Magnitude of Residues in Meat and Milk from Lactating Dairy Cows Exposed 

to Pyrethrum Extract: Addendum No. 1 to Amended Final Report: Lab Project Number: 94-0020. 

Unpublished study prepared by EN-CAS Analytical Labs. 54 p. 

44140402 Winkler, D.; Huff, D. (1995) Magnitude of Residues in Meat and Milk from Lactating Dairy Cows Exposed 

to Pyrethrum Extract: Amended Final Report: Lab Project Number: 94-0020: 890. Unpublished study 

prepared by EN-CAS Analytical Labs and PTRL East, Inc. 639 p. 

44126901 Hattermann, D. (1996) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Leafy Vegetables: 

Amended Final Report: (Includes "Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw

Agricultural Commodity Trials on Leafy Vegetables in CA, FL, AZ, MI, CO, & TX"): Lab Project Number: 

18009A003: 93-0064: BD-007-93. Unpublished study prepared by Landis International, Inc.; EN-CAS 

Analytical Labs; and Pharmaco LSR International, Inc. 456 p. 

42009801 Meinen, V.; Bergman, J. (1991) Residue Study of Pyrethrins, Piperonyl Butoxide, and MGK 264 in Certain 

Food Commodities Resulting from Use as a Space in a Simulated Feed and Food Processing Situation: Lab 

Project Number: GLP-078. Unpublished study prepared by MGK Co. 145 p. 

42009802 Meinen, V.; Bergman, J. (1991) Residue Study of Pyrethrins, Piperonyl Butoxide, and MGK 264 in Certain 

Food Commodities Resulting from Use as a Contact Spray in a Simulated Feed and Food Processing 

Situation: Lab Project Number: GLP-075. Unpublished study prepared by MGK Co. 146 p. 

42009803 Meinen, V. (1991) Residue Study of Pyrethrins, Piperonyl Butoxide, and MGK 264 in Certain Food 

Commodities Resulting from Use as a Space Spray in a Warehouse Situation: Lab Project Number: GLP077. Unpublished study prepared by MGK Co. 116 p. 

42009804 Meinen, V. (1991) Residue Study of Pyrethrins, Piperonyl Butoxide, and MGK 264 in Certain Food 

Commodities Resulting from Use as a Contact Spray in a Warehouse Situation: Lab Project Number: GLP076. Unpublished study prepared by MGK Co. 114 p. 

42009805 Meinen, V.; Bergman, J. (1991) Residue Study of Pyrethrins, Piperonyl Butoxide, and MGK 264 in Certain 

Food Commodities and Surfaces Resulting From Use as an Intermediate Aerosol Spray in a Simulated 

Restaurant Situation: Lab Project Number: GLP-193. Unpublished study prepared by MGK Co. 199 p. 
8

MRID# Study

43833401 Winkler, D.; Huff, D. (1995) Magnitude of Residues in Meat and Milk from Lactating Dairy Cows Exposed 

to Pyrethrum Extract: Amended Final Report: Lab Project Number: 94-0020: 890. Unpublished study 

prepared by EN-CAS Analytical Labs and PTRL East, Inc. 639 p. 

43833402 Winkler, D.; Huff, D. (1995) Magnitude of Residues in Meat and Eggs from Laying Hens Exposed to 

Pyrethrum Extract: Amended Final Report: Lab Project Number: 94-0022: 891. Unpublished study prepared 

by EN-CAS Analytical Labs and PTRL East, Inc. 583 p. 

45900801 Singer, S.; Curry, K.; Brookman, D. (2003) Response to Chemistry and Exposure Branch Review Dated 

March 19, 1999 Regarding Magnitude of Pyrethrin (PY) Residues in Plants: Lab Project Number: 68-D4-

0010: EL8228-S1: ENC-14/93. Unpublished study prepared by En-Cas Analytical Laboratories. 197 p. 

45037101 Hatterman, D. (1999) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Legumes: Lab Project 

Number: 1714-91-180-02-07G81: 1714-91-180-02-07D78: 1714-91-180-02-07E77. Unpublished study 

prepared by Landis International, Inc. and Agvise, Inc. 652 p. 

43470806 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation 

of Pyrethrin Applied as Pyrenone Crop Spray to Legumes: Final Report: (Includes "Field Phase for 

LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural Commodity Trial on Legumes FL, WI, ND, 

CO, CA, MN, TX, and WA"): Lab Project Number: 18007A012: 714-91-180-02-07E-76: 714-91-180-02-

07E-77. Unpublished study prepared by Paragon Global Services; EN-CAS Analytical Labs; and Pharmaco 

LSR International Inc. 604 p. 

45037101 Hatterman, D. (1999) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Legumes: Lab Project 

Number: 1714-91-180-02-07G81: 1714-91-180-02-07D78: 1714-91-180-02-07E77. Unpublished study 

prepared by Landis International, Inc. and Agvise, Inc. 652 p. 

43470806 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation 

of Pyrethrin Applied as Pyrenone Crop Spray to Legumes: Final Report: (Includes "Field Phase for 

LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural Commodity Trial on Legumes FL, WI, ND, 

CO, CA, MN, TX, and WA"): Lab Project Number: 18007A012: 714-91-180-02-07E-76: 714-91-180-02-

07E-77. Unpublished study prepared by Paragon Global Services; EN-CAS Analytical Labs; and Pharmaco 

LSR International Inc. 604 p. 

43470805 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation 

of Pyrethrin Applied as Pyrenone Crop Spray to Root and Tuber Crops: Final Report: (Includes "Field Phase 

for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural Commodity Trial on Root and Tuber 

Crops in TX, FL, ID, CO, ME, ND, and MN"): Lab Project Number: 18008A001: 714-91-180-02-08F-23: 

714-91-180-02-08J-24. Unpublished study prepared by Paragon Global Services; EN-CAS Analytical Labs; 

and Pharmaco LSR International Inc. 362 p. 

43370801 Hattermann, D. (1994) Volume I: Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw 

Agricultural Commodity Trials on Small Fruits in New York, Oregon, Michigan, North Carolina, Florida, 

and Massachusetts; Volume II: Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin Applied as Pyrenone Crop Spray to Small Fruits: Final Report: Lab Project 

Number: 18003A020. Unpublished study prepared by Paragon Global Services, EN-CAS Analytical Lab., 

and Pharmaco LSR International Inc. 324 p. 
9

MRID# Study

43370801 Hattermann, D. (1994) Volume I: Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw 

Agricultural Commodity Trials on Small Fruits in New York, Oregon, Michigan, North Carolina, Florida, 

and Massachusetts; Volume II: Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin Applied as Pyrenone Crop Spray to Small Fruits: Final Report: Lab Project 

Number: 18003A020. Unpublished study prepared by Paragon Global Services, EN-CAS Analytical Lab., 

and Pharmaco LSR International Inc. 324 p. 

45398401 Hatterman, D. (2001) Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural 

Commodity Trials on Brassica in Arkansas, California, Oregon, New York, Florida, Texas and Georgia: 

Amended Final Report: Lab Project Number: 18014A004: 1714-91-180-02-14D-37/AR. Unpublished study 

prepared by Landis International, Inc. 503 p. 

43292701 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity residue evaluation 

of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Brassica, including Field Phase for 

LX1180-20: Final Report: Lab Project Number: 18014A004. Unpublished study prepared by En-CAS 

Analytical Lab., Pharmaco LSR International Inc. 472 p. 

43470805 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation 

of Pyrethrin Applied as Pyrenone Crop Spray to Root and Tuber Crops: Final Report: (Includes "Field Phase 

for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural Commodity Trial on Root and Tuber 

Crops in TX, FL, ID, CO, ME, ND, and MN"): Lab Project Number: 18008A001: 714-91-180-02-08F-23: 

714-91-180-02-08J-24. Unpublished study prepared by Paragon Global Services; EN-CAS Analytical Labs; 

and Pharmaco LSR International Inc. 362 p. 

44126901 Hattermann, D. (1996) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Leafy Vegetables: 

Amended Final Report: (Includes "Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw

Agricultural Commodity Trials on Leafy Vegetables in CA, FL, AZ, MI, CO, & TX"): Lab Project Number: 

18009A003: 93-0064: BD-007-93. Unpublished study prepared by Landis International, Inc.; EN-CAS 

Analytical Labs; and Pharmaco LSR International, Inc. 456 p. 

43232801 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation 

of Pyrethrin & Piperonyl Butoxide Applied as Pyrenone Crop Spray to Leafy Vegetables (Also Field Phase 

for Raw Agricultural Commodity Trials on Leafy Vegetables): Lab Project Number: 18009A003. 

Unpublished study prepared by EN-CAS Analytical Labs. and PHARMACO LSR International Inc. 423 p. 

43910601 Hattermann, D. (1996) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Leafy Vegetables: 

Amended Final Report: (Includes "Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw

Agricultural Commodity Trials on Leafy Vegetables in CA, FL, AZ, MI, CO, & TX"): Lab Project Number: 

18009A003: 93-0064: BD-007-93. Unpublished study prepared by Landis International, Inc.; EN-CAS 

Analytical Labs; and Pharmaco LSR International, Inc. 456 p. 

43370801 Hattermann, D. (1994) Volume I: Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw 

Agricultural Commodity Trials on Small Fruits in New York, Oregon, Michigan, North Carolina, Florida, 

and Massachusetts; Volume II: Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin Applied as Pyrenone Crop Spray to Small Fruits: Final Report: Lab Project 

Number: 18003A020. Unpublished study prepared by Paragon Global Services, EN-CAS Analytical Lab., 

and Pharmaco LSR International Inc. 324 p. 
10

MRID# Study

45048001 Hatterman, D. (1997) Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural 

Commodity Trials on Cucurbits in Michigan, North Carolina, Arizona, California, Florida, Texas, New

Jersey and Georgia: Amended Final Report: Lab Project Number: 18013A007: 1714-91-180-02-13B-5: 714-

91-180-02-13B-54. Unpublished study prepared by Landis International, Inc. 111 p. 

43248701 Hattermann, D. (1994) Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural 

Commodity Trials on Cucurbits in Michigan, North Carolina, Arizona, California, Florida, Texas, New

Jersey and Georgia: Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation of 

Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Cucurbits: Final Report: Lab Project 

Number: 18013A007. Unpublished study prepared by Paragon Global Services. 379 p. 

43440002 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation 

of Pyrethrin Applied as Pyrenone Crop Spray to Citrus Crops: (Including Field and Processing Phases for 

LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural Commodity Trials on Citrus in FL, CA, TX, 

and AZ): Lab Project Numbers: 18001A014: BD-007-93: 93-0075. Unpublished study prepared by Paragon 

Global Services. 310 p. 

43370801 Hattermann, D. (1994) Volume I: Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw 

Agricultural Commodity Trials on Small Fruits in New York, Oregon, Michigan, North Carolina, Florida, 

and Massachusetts; Volume II: Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin Applied as Pyrenone Crop Spray to Small Fruits: Final Report: Lab Project 

Number: 18003A020. Unpublished study prepared by Paragon Global Services, EN-CAS Analytical Lab., 

and Pharmaco LSR International Inc. 324 p. 

43440002 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation 

of Pyrethrin Applied as Pyrenone Crop Spray to Citrus Crops: (Including Field and Processing Phases for 

LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural Commodity Trials on Citrus in FL, CA, TX, 

and AZ): Lab Project Numbers: 18001A014: BD-007-93: 93-0075. Unpublished study prepared by Paragon 

Global Services. 310 p. 

44126901 Hattermann, D. (1996) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Leafy Vegetables: 

Amended Final Report: (Includes "Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw

Agricultural Commodity Trials on Leafy Vegetables in CA, FL, AZ, MI, CO, & TX"): Lab Project Number: 

18009A003: 93-0064: BD-007-93. Unpublished study prepared by Landis International, Inc.; EN-CAS 

Analytical Labs; and Pharmaco LSR International, Inc. 456 p. 

43232801 Hattermann, D. (1994) Pyrethrin Analytical Phase for Pyrenone Crop Spray (Pyrethrin + Piperonyl 

Butoxide) Aquatic Dissipation Study Applied Post-Emergence to Barewater in California, Arkansas, and 

Mississippi: Lab Project Number: 18021V09: 91190: BD-047-92. Unpublished study prepared by Pharmaco 

LSR International, Inc. and Landis International, Inc. 152 p 

43910601 Hattermann, D. (1996) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Leafy Vegetables: 

Amended Final Report: (Includes "Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw

Agricultural Commodity Trials on Leafy Vegetables in CA, FL, AZ, MI, CO, & TX"): Lab Project Number: 

18009A003: 93-0064: BD-007-93. Unpublished study prepared by Landis International, Inc.; EN-CAS 

Analytical Labs; and Pharmaco LSR International, Inc. 456 p. 
11

MRID# Study

44126901 Hattermann, D. (1996) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Leafy Vegetables: 

Amended Final Report: (Includes "Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw

Agricultural Commodity Trials on Leafy Vegetables in CA, FL, AZ, MI, CO, & TX"): Lab Project Number: 

18009A003: 93-0064: BD-007-93. Unpublished study prepared by Landis International, Inc.; EN-CAS 

Analytical Labs; and Pharmaco LSR International, Inc. 456 p.

43232801 Hattermann, D. (1994) Pyrethrin Analytical Phase for Pyrenone Crop Spray (Pyrethrin + Piperonyl 

Butoxide) Aquatic Dissipation Study Applied Post-Emergence to Barewater in California, Arkansas, and 

Mississippi: Lab Project Number: 18021V09: 91190: BD-047-92. Unpublished study prepared by Pharmaco 

LSR International, Inc. and Landis International, Inc. 152 p 

43910601 Hattermann, D. (1996) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Leafy Vegetables: 

Amended Final Report: (Includes "Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw

Agricultural Commodity Trials on Leafy Vegetables in CA, FL, AZ, MI, CO, & TX"): Lab Project Number: 

18009A003: 93-0064: BD-007-93. Unpublished study prepared by Landis International, Inc.; EN-CAS 

Analytical Labs; and Pharmaco LSR International, Inc. 456 p. 

45048001 Hatterman, D. (1997) Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural 

Commodity Trials on Cucurbits in Michigan, North Carolina, Arizona, California, Florida, Texas, New

Jersey and Georgia: Amended Final Report: Lab Project Number: 18013A007: 1714-91-180-02-13B-5: 714-

91-180-02-13B-54. Unpublished study prepared by Landis International, Inc. 111 p. 

43248701 Hattermann, D. (1994) Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural 

Commodity Trials on Cucurbits in Michigan, North Carolina, Arizona, California, Florida, Texas, New

Jersey and Georgia: Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation of 

Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Cucurbits: Final Report: Lab Project 

Number: 18013A007. Unpublished study prepared by Paragon Global Services. 379 p. 

43248701 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity residue evaluation 

of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Brassica, including Field Phase for 

LX1180-20: Final Report: Lab Project Number: 18014A004. Unpublished study prepared by En-CAS 

Analytical Lab., Pharmaco LSR International Inc. 472 p. 

43292701 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity residue evaluation 

of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Brassica, including Field Phase for 

LX1180-20: Final Report: Lab Project Number: 18014A004. Unpublished study prepared by En-CAS 

Analytical Lab., Pharmaco LSR International Inc. 472 p. 

43440002 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation 

of Pyrethrin Applied as Pyrenone Crop Spray to Citrus Crops: (Including Field and Processing Phases for 

LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural Commodity Trials on Citrus in FL, CA, TX, 

and AZ): Lab Project Numbers: 18001A014: BD-007-93: 93-0075. Unpublished study prepared by Paragon 

Global Services. 310 p. 
12

MRID# Study

45037101 Hatterman, D. (1999) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Legumes: Lab Project 

Number: 1714-91-180-02-07G81: 1714-91-180-02-07D78: 1714-91-180-02-07E77. Unpublished study 

prepared by Landis International, Inc. and Agvise, Inc. 652 p. 

43470806 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation 

of Pyrethrin Applied as Pyrenone Crop Spray to Legumes: Final Report: (Includes "Field Phase for 

LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural Commodity Trial on Legumes FL, WI, ND, 

CO, CA, MN, TX, and WA"): Lab Project Number: 18007A012: 714-91-180-02-07E-76: 714-91-180-02-

07E-77. Unpublished study prepared by Paragon Global Services; EN-CAS Analytical Labs; and Pharmaco 

LSR International Inc. 604 p. 

45037101 Hatterman, D. (1999) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Legumes: Lab Project 

Number: 1714-91-180-02-07G81: 1714-91-180-02-07D78: 1714-91-180-02-07E77. Unpublished study 

prepared by Landis International, Inc. and Agvise, Inc. 652 p. 

43470806 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation 

of Pyrethrin Applied as Pyrenone Crop Spray to Legumes: Final Report: (Includes "Field Phase for 

LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural Commodity Trial on Legumes FL, WI, ND, 

CO, CA, MN, TX, and WA"): Lab Project Number: 18007A012: 714-91-180-02-07E-76: 714-91-180-02-

07E-77. Unpublished study prepared by Paragon Global Services; EN-CAS Analytical Labs; and Pharmaco 

LSR International Inc. 604 p. 

43298901 Hattermann, D. (1994) Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural 

Commodity Trials on Fruiting Vegetable in Florida, Michigan, New Jersey, North Carolina, California, and 

Texas: Final Report: including Analytical Phase: Lab Project Number: 18015A005. Unpublished study 

prepared by Paragon Global Services, En-Cas Analytical Labs, and Pharmaco LSR International Inc. 272 p. 

43470805 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation 

of Pyrethrin Applied as Pyrenone Crop Spray to Root and Tuber Crops: Final Report: (Includes "Field Phase 

for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural Commodity Trial on Root and Tuber 

Crops in TX, FL, ID, CO, ME, ND, and MN"): Lab Project Number: 18008A001: 714-91-180-02-08F-23: 

714-91-180-02-08J-24. Unpublished study prepared by Paragon Global Services; EN-CAS Analytical Labs; 

and Pharmaco LSR International Inc. 362 p. 

43470805 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation 

of Pyrethrin Applied as Pyrenone Crop Spray to Root and Tuber Crops: Final Report: (Includes "Field Phase 

for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural Commodity Trial on Root and Tuber 

Crops in TX, FL, ID, CO, ME, ND, and MN"): Lab Project Number: 18008A001: 714-91-180-02-08F-23: 

714-91-180-02-08J-24. Unpublished study prepared by Paragon Global Services; EN-CAS Analytical Labs; 

and Pharmaco LSR International Inc. 362 p. 

44126901 Hattermann, D. (1996) Amended Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Leafy Vegetables: 

Amended Final Report: (Includes "Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw

Agricultural Commodity Trials on Leafy Vegetables in CA, FL, AZ, MI, CO, & TX"): Lab Project Number: 

18009A003: 93-0064: BD-007-93. Unpublished study prepared by Landis International, Inc.; EN-CAS 

Analytical Labs; and Pharmaco LSR International, Inc. 456 p. 
13

MRID# Study

43232801 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation 

of Pyrethrin & Piperonyl Butoxide Applied as Pyrenone Crop Spray to Leafy Vegetables (Also Field Phase 

for Raw Agricultural Commodity Trials on Leafy Vegetables): Lab Project Number: 18009A003. 

Unpublished study prepared by EN-CAS Analytical Labs. and PHARMACO LSR International Inc. 423 p. 

45048001 Hatterman, D. (1997) Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural 

Commodity Trials on Cucurbits in Michigan, North Carolina, Arizona, California, Florida, Texas, New

Jersey and Georgia: Amended Final Report: Lab Project Number: 18013A007: 1714-91-180-02-13B-5: 714-

91-180-02-13B-54. Unpublished study prepared by Landis International, Inc. 111 p. 

43248701 Hattermann, D. (1994) Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural 

Commodity Trials on Cucurbits in Michigan, North Carolina, Arizona, California, Florida, Texas, New

Jersey and Georgia: Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue Evaluation of 

Pyrethrin + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Cucurbits: Final Report: Lab Project 

Number: 18013A007. Unpublished study prepared by Paragon Global Services. 379 p. 

43370801 Hattermann, D. (1994) Volume I: Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw 

Agricultural Commodity Trials on Small Fruits in New York, Oregon, Michigan, North Carolina, Florida, 

and Massachusetts; Volume II: Pyrethrin Analytical Phase on the Raw Agricultural Commodity Residue 

Evaluation of Pyrethrin Applied as Pyrenone Crop Spray to Small Fruits: Final Report: Lab Project 

Number: 18003A020. Unpublished study prepared by Paragon Global Services, EN-CAS Analytical Lab., 

and Pharmaco LSR International Inc. 324 p. 

43298901 Hattermann, D. (1994) Field Phase for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Raw Agricultural 

Commodity Trials on Fruiting Vegetable in Florida, Michigan, New Jersey, North Carolina, California, and 

Texas: Final Report: including Analytical Phase: Lab Project Number: 18015A005. Unpublished study 

prepared by Paragon Global Services, En-Cas Analytical Labs, and Pharmaco LSR International Inc. 272 p. 

47225601 Hattermann, D. (2007) Raw Agricultural Commodity (RAC) Residue Decline of Pyrethrins/Piperonyl 

Butoxide Applied to Tomatoes. Project Number: 18015A023, 060230. Unpublished study prepared by 

Landis International, Inc. 248 p. 

47225602 Hattermann, D. (2007) Raw Agricultural Commodity (RAC) Residue Decline of Pyrethrins/Piperonyl 

Butoxide Applied to Lettuce. Project Number: 18009A024, 060231. Unpublished study prepared by 

Landis International, Inc. 262 p. 

47225603 Hattermann, D. (2007) Raw Agricultural Commodity (RAC) Residue Decline of Pyrethrins/Piperonyl 

Butoxide Applied to Peaches. Project Number: 18002A025, 060232. Unpublished study prepared by 

Landis International, Inc. 258 p. 

47225604 Hattermann, D. (2007) Raw Agricultural Commodity (RAC) Residue Decline of Pyrethrins/Piperonyl 

Butoxide Applied to Blueberry. Project Number: 18003A026, 060233. Unpublished study prepared by 

Landis International, Inc. 281 p. 

45900801 Singer, S.; Curry, K.; Brookman, D. (2003) Response to Chemistry and Exposure Branch Review Dated 

March 19, 1999 Regarding Magnitude of Pyrethrin (PY) Residues in Plants: Lab Project Number: 68-D4-

0010: EL8228-S1: ENC-14/93. Unpublished study prepared by En-Cas Analytical Laboratories. 197 p. 
14

MRID# Study

43470803 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Processed Commodity Residue Evaluation of 

Pyrethrin Applied as Pyrenone Crop Spray to Succulent Beans: Final Report: (Includes "Field and 

Processing Phases for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Processed Commodity Trial on 

Succulent Beans in NY"): Lab Project Number: 18007E013: 714-91-180-02-07E-83. Unpublished study 

prepared by Paragon Global Services; EN-CAS Analytical Labs; and Pharmaco LSR International Inc. 185 

p. 

43470804 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Processed Commodity Residue Evaluation of 

Pyrethrin Applied as Pyrenone Crop Spray to Root and Tuber Crops: Final Report: (Includes "Field and 

Processing Phases for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Processed Commodity Trial on Potatoes 

and Sugarbeets in WA and CA"): Lab Project Number: 18008A002: 714-91-180-02-08B-29: 714-91-180-

02-08D-21. Unpublished study prepared by Paragon Global Services; EN-CAS Analytical Labs; and 

Pharmaco LSR International Inc. 350 p. 

43470802 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Processed Commodity Residue Evaluation of 

Pyrethrin Applied as Pyrenone Crop Spray to Oranges: Final Report: (Includes "Field and Processing Phases 

for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Processed Commodity Trial on Oranges in FL"): Lab 

Project Number: 18001B015: 714-91-180-02-01B-93. Unpublished study prepared by Paragon Global 

Services; EN-CAS Analytical Labs; and Pharmaco LSR International Inc. 272 p. 

43440001 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Processed Commodity Residue Evaluation of 

Pyrethrin Applied as Pyrenone Crop Spray to Grape: (including Field and Processing Phases for LX1180-02 

(Pyrethrin + Piperonyl Butoxide) Processed Commodity Trial on Grape in California): Lab Project Number: 

18003B019: 93-0074: 1714-92-180-02-03B-03. Unpublished study prepared by Paragon Global Services. 

295 p. 

43470804 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Processed Commodity Residue Evaluation of 

Pyrethrin Applied as Pyrenone Crop Spray to Root and Tuber Crops: Final Report: (Includes "Field and 

Processing Phases for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Processed Commodity Trial on Potatoes 

and Sugarbeets in WA and CA"): Lab Project Number: 18008A002: 714-91-180-02-08B-29: 714-91-180-

02-08D-21. Unpublished study prepared by Paragon Global Services; EN-CAS Analytical Labs; and 

Pharmaco LSR International Inc. 350 p. 

43910601 Hattermann, D. (1996) Pyrethrin Analytical Phase on the Processed Commodity Residue Evaluation of 

Pyrethrins + Piperonyl Butoxide Applied as Pyrenone Crop Spray to Root and Tuber Crops: (Includes 

"Field and Processing Phases for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Processed Commodity Trial 

on Potatoes in Washington"): Amended Final Report: Lab Project Number: 1714-95-180-02-08D-03: 95-

0013-2: 18008D022. Unpublished study prepared by Landis International, Inc. and EN-CAS Analytical 

Labs. 249 p.

43470801 Hattermann, D. (1994) Pyrethrin Analytical Phase on the Processed Commodity Residue Evaluation of 

Pyrethrin Applied as Pyrenone Crop Spray to Tomato: Final Report: (Includes "Field and Processing Phases 

for LX1180-02 (Pyrethrin + Piperonyl Butoxide) Processed Commodity Trial on Tomato in CA"): Lab 

Project Number: 18015B006: 714-91-180-02-15B-52. Unpublished study prepared by Paragon Global

Services; EN-CAS Analytical Labs; and Pharmaco LSR International Inc. 306 p. 

44460801 Maciver, D.; Keane, P.; Jones, D.; et al. (1997) Pyrethrins and Piperonyl Butoxide as Public Health 

Insecticides. Unpublished study prepared by Pyrethrin Joint Venture and Piperonyl Butoxide Task Force. 

35 p. 

45284601 Solecki, R. (2000) 1999 JMPR Monograph Addendum for Pyrethrin Extracts (Pyrethrins). Unpublished 

study prepared by Bundesinstitut fur gesundheitlichen Verbraucherschutz und Veterinardmedizin. 22 p. 
15

MRID# Study

45921601 Technology Sciences Group (2003) Pyrethrin Joint Venture Compilation of Use Information. Unpublished 

study prepared by Consumer Specialty Products Association. 65 p. 

46027301 Pegus Research, Inc. (2001) Human Exposures to Consumer Products Containing Pyrethrins and 

Pyrethroids: Reports to the American Association of Poison Control Centers: 1994-1999. Unpublished 

study. 38 p. 

46261001 Cathcart, C. (2004) Evaluation of the Safety of Synergized Pyrethrins Formulations. Unpublished study 

prepared by Science Strategies LLC. 19 p. 

46694801 Osimitz, T.; Sommers, N.; Kingston, R. (2005) Human Exposures to Products Containing Pyrethrins and 

Piperonyl Butoxide: Analysis of Poison Control Center Data (2001-2003). Unpublished study prepared by 

Science Strategies. 28 p.

46757301 Osimitz, T.; Franzosa, J.; Maciver, D.; et. al. (2006) Pyrethrins Allergic Contact Dermatitis in Man - An 

Evidence-Based Dermatologic Review. Unpublished study prepared by Science Strategies and University of 

California. 35 p.

46792702 Bretzlaff, R.; Sielken, R. (2006) Analysis of Pyrethrin - Induced Changes in Female Sprague - Dawley Rat 

Liver. Unpublished study prepared by Sielken, Inc. 57 p. 

46792703 Lake, B. (2006) An Investigation of the Effects of Pyrethrins on Some Cytochrome P450 Forms in Cultured 

Rat and Human Hepatocytes. Project Number: 4024/4, 4024/4/2/2006. Unpublished study prepared by 

Pyrethrin Joint Venture. 88 p. 

46792704 Klaunig, J. (2006) Examination of Mode of Action of Pyrethrins Tumorigenesis in Mammals. Unpublished 

study prepared by Indiana University School of Medicine. 42 p. 

46864601 Osimitz, T.; Franzosa, J. (2006) Pyrethrins and Respiratory Reactions - A Critical Review. Unpublished 

study prepared by Science Strategies. 20 p. 

47036701 Lake, B. (2006) An Investigation of the Effects of Pyrethrins on some Rat Hepatic Peroxisomal Enzyme 

Activities. Project Number: 4024/5, 4024/5/2/2006. Unpublished study prepared by Pyrethrin Joint 

Venture. 40 p. 

47241701 Osimitz, T.; Lake, B. (2007) Mode of Action Analysis for Rodent Liver Tumors Produced by Pyrethrins. 

Unpublished study prepared by Science Strategies, LLC and Leatherhead Food International. 59 p. 

47464001 O'Shaughnessy, D.; Osimitz, T. (2008) Waiver Request-Regarding Requirement for Developmental 

Neurotoxicity Study for Pyrethrins. Unpublished study prepared by Science Strategies and DOC Consulting 

. 8 p. 

47464002 O'Shaughnessy, D. (2008) Re-evaluation of Microscopic Pathology in Nervous System Tissues from Bushy 

Run Research Center Study 92N1036 (Acute Oral Neurotoxicity of Pyrethrum Extract in Rats). 

Unpublished study prepared by DOC, Inc. 7 p. 

47588101 Sharp, J.; Thom, E.; Carlson, D.; et. al.; (2008) Pyrethrins Joint Venture Proposal to Fulfill Reregistration 

Requirements for Crop Pre-Harvest Residue: Response to EPA'S Review of Pyrethrins Studies on 

Tomatoes, Lettuce, Peaches, and Blueberries - EPA Letter Dated August 22, 2008. Unpublished study 

prepared by Consumer Specialty Products Association, Inc. (CSPA). 26 p.