Exhibit 10.53


  


 


 


 


PROMISSORY NOTE


 


 





	$15,000,000.00                 	February 13, 2014
	New York, New York   	 







 


 


FOR VALUE
RECEIVED, the undersigned, CORONADO BIOSCIENCES, INC., (the “Borrower”) HEREBY PROMISES TO
PAY to the order of ISRAEL DISCOUNT BANK OF NEW YORK, its successors and assigns (hereinafter the
“Bank”), the principal amount of FIFTEEN MILLION and 00/100 DOLLARS ($15,000,000.00), in lawful
money of the United States (the “Loan”), or the aggregate unpaid principal amount of all revolving credit
advances (hereinafter each being referred to as an “Advance” and collectively, the
“Advances”) made to Borrower, as set forth on Bank’s computer system on the Loan Enquiry Page(s)
(the “Loan Enquiry Page(s)”) on the Maturity Date, and to pay interest on the unpaid principal balance of
this Promissory Note (this “Note”) in the manner and at the rate as hereinafter specified and such amounts
due hereunder.


 


		1.	Defined Terms. As used in this Note the following terms shall have the following
meanings:



 


The term “Additional
Costs” shall have the meaning as defined in Section 17.


 


The terms “Advance”
or “Advances” shall have the meanings as defined in the introductory paragraph.


 


The term “Bank”
shall have the meaning as defined in the introductory paragraph.


 


The term “Bankruptcy
Code” shall mean Title 11 of the United States Code, as amended.


 


The term “Borrower”
shall have the meaning as defined in the introductory paragraph.


 


The term “Business
Day” shall mean any day other than a Saturday, Sunday, or other day on which commercial banks in New York are authorized
or required to close under the laws of the State of New York.


 


The term “Collateral”
or “Collateral Account” shall be that certain MMA account of Coronado Biosciences, Inc.  in an amount of $15,000,000.00
but at all times of no less than any outstanding Advances under this Note pledged by  Coronado Biosciences, Inc. to Bank,
together with any replacements, renewals or extensions thereof.


 


The term “Default
Interest Rate” shall have the meaning as defined in Section 4.


 


The term “Event
of Default” shall mean any of the events or conditions specified in Section 12 hereof.


 


The term “Indebtedness”
shall mean all items of indebtedness, obligation or liability, whether matured or unmatured, liquidated or unliquidated, funded
or unfunded, direct or contingent, joint or several, which would properly be included in the liability section of a balance sheet
or in a footnote to a financial statement in accordance with generally accepted accounting principles, and shall also include (a)
all indebtedness guaranteed, directly or indirectly in any manner, or endorsed (other than for collection or deposit in the ordinary
course of business) or sold with recourse, (b) all indebtedness in effect guaranteed, directly or indirectly, through agreements,
contingent or otherwise, and (c) all indebtedness secured by (or for which the holder of such indebtedness has a right, contingent
or otherwise, to be secured by) any mortgage, deed of trust, pledge, assignment, lien, security interest or other charge or encumbrance
upon property owned or acquired subject thereto, whether or not the liabilities secured thereby have been assumed or guaranteed.


 






    	 



    	 



    

 


The terms “Indemnified
Party” or “Indemnified Parties” shall have the meanings as defined in Section 27.


 


The term “Interest”
means the annual rate of interest payable on the outstanding Advances in accordance with Sections 3 and 4.


 


The term “Late
Charge” shall have the meaning as defined in Section 10.


 


The term “Loan”
shall have the meaning as defined in the introductory paragraph.


 


The term “Loan
Documents” shall mean this Note and any other document, instrument or agreement, entered into in connection with the
Indebtedness evidenced by this Note, all as amended, restated, extended, renewed, supplemented, modified or replaced from time
to time.


  


The term “Loan
Enquiry Page(s)” shall have the meaning as defined in the introductory paragraph.


 


The term “Margin”
shall mean one hundred fifty basis points (150 bps).


 


The term “Maturity
Date” shall mean February 13, 2016. 


 


The term “Minimum
Advance” shall have the meaning as defined in Section 2(c).


 


The term “Note”
shall mean this Promissory Note.


  


The term “Obligations”
shall mean all existing and future debts, liabilities and obligations of every kind or nature at any time owing by Borrower to
Bank, under this Note or under any other Loan Document, including, without limitation, the debts,
liabilities and obligations in respect of this Note and any extensions, modifications, substitutions, increases and renewals thereof.



 


The term “Obligor” shall
mean individually and collectively Borrower, each endorser and surety of this Note, any person who is primarily or secondarily
liable for the repayment of this Note or any portion thereof, any person who has granted security for the repayment of the Note,
together with such person’s heirs, personal representatives, successors and assigns.


 



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		2.	Advances.



 


		(a)	Each request by Borrower for an Advance shall be received
by Bank not later than 12:00 noon, New York local time, on the date of such request.



 


(b)
 Each request for an Advance shall specify (i) the requested date of such Advance (ii) the requested amount of such Advance
and (iii) the purpose of such Advance.


 


(c) 
 A request for an Advance shall be irrevocable upon Bank’s first receiving notification thereof and shall be in
a minimum amount (“Minimum Advance”) of: (i) $100,000.00; or (ii) the remaining amount of the available undrawn
balance under the Loan if such amount is less than $100,000.00.


 


(d)  Subject to the terms and conditions hereof and the terms and conditions set forth in the Loan Documents, Advances that
are repaid or pepaid may be reborrowed on a revolving basis up to the maximum amount of this Note.


  


(e) 
 Borrower shall utilize the Advances for prior loan repayment and to fund general working
capital needs.


  


		3.	Principal and Interest.



 


(a)   
Interest shall be payable on the outstanding daily unpaid principal amount of each Advance from the date hereof until payment
in full is made and shall accrue and be payable at the rates set forth or provided for herein, before and after default, before
and after maturity, before and after judgment and before and after the commencement of any proceeding under the Bankruptcy Code,
with interest on overdue interest to bear interest and to be compounded at the Default Interest Rate, in each case, to the fullest
extent permitted by applicable laws.


 


(b)
  Interest accrued on each Advance shall be due and payable in arrears on the first day of each calendar month commencing on
the first day of the first full month following the date of such Advance and at maturity (whether as stated or by acceleration).
Except as otherwise provided in Section 4, the unpaid principal amount of each Advance shall bear interest at a rate per annum
equal to the interest rate payable on the Collateral Account plus the Margin. 


 


(c) 
 If not sooner paid, the unpaid principal amount of each Advance shall be due and payable on the
Maturity Date.


 


(d)
 The unpaid principal amount of any Advance may, at any time and from time to time, be voluntarily paid or prepaid in
whole or in part except that, with respect to any voluntary prepayment, (i) Bank shall have received written notice of any prepayment
by 12:00 noon, New York local time on the date of prepayment (which must be a Business Day), which notice shall identify the date
and amount of the prepayment and (ii) each prepayment of an Advance shall be accompanied by payment of interest accrued to the
date of payment on the amount of principal paid.


 


(e)  
Bank may act without liability upon the basis of telephonic notice believed by Bank in good faith to be from Borrower.
Borrower shall immediately confirm to Bank, in writing, each telephonic notice. All Advances are made at Bank’s sole and
absolute discretion and Bank may, at its option and in its sole and absolute discretion and without notice to the undersigned,
decline to make any Advance requested by Borrower. Borrower hereby expressly authorizes Bank to record in its computer system the
amount and date of each Advance, the applicable rate of interest, the Maturity Date, and each payment of principal and interest
thereon. In the event of any discrepancy between any such notation by Bank and any records of Borrower, the records of Bank shall
be controlling and conclusive absent manifest error.


 


(f)   All amounts due and owing hereunder
shall be paid in full no later than the earlier of:   (i) the Maturity Date; or (ii) at the Bank’s
election following the occurrence and continuation of an Event of Default.


 



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    4.    Default
Rate. At the option of the Bank, upon the occurrence and during the continuance of any
Event of Default, and in any event if any installment of principal or interest or any fee or cost or other amount payable under
this Note, or any other Loan Document, is not paid when due, the Obligations shall thereafter bear interest at a fluctuating interest
rate per annum at all times equal to the rate otherwise applicable thereto plus three (3%) percent per annum (the “Default
Interest Rate”), to the fullest extent permitted by applicable law. Accrued and unpaid interest on past due amounts
(including interest on past due interest) shall be compounded monthly, on the last day of each calendar month, to the fullest
extent permitted by applicable law.


 


		5.	Computation of Interest and Fees.



 


		(a)	Computation of interest on the Loan shall be calculated on the basis of a year of 360 days and the actual number of days elapsed.
Borrower acknowledges that such latter calculation method will result in a higher yield to the Lender than a method based on a
year of 365 or 366 days.



 


		(b)	Under no circumstances or event whatsoever shall the
aggregate of all amounts deemed interest hereunder and charged or collected pursuant to the terms of this Note exceed the highest
rate permissible under any law which a court of competent jurisdiction shall, in a final determination, deem applicable hereto.
In the event that such court determines Bank has charged or received interest hereunder in excess of the highest applicable rate,
Bank shall apply, in its sole discretion, and set off such excess interest received by Bank against other Obligations due or to
become due and such rate shall automatically be reduced to the maximum rate permitted by such law.



 


		6.	Manner and Treatment of Payments.



 


(a)          
Each payment due on this Note, or under any other Loan Document, shall be made to Bank, at Bank’s office located at
511 Fifth Avenue, New York, New York 10017-4997, for the account of Bank, in immediately available funds not later than 3:00 p.m.,
New York local time, on the day of payment (which must be a Business Day). All payments received after these deadlines shall be
deemed received on the next succeeding Business Day. All payments shall be made in lawful money of the United States of America.


 


(b)          
Bank shall have the unconditional right and discretion (and Borrower hereby authorizes Bank) to charge Borrower’s
operating and/or deposit account(s) for all of Borrower’s Obligations as they become due from time to time under this Note,
or any other Loan Document, including, without limitation, interest, principal, fees, indemnification obligations (unless disputed
by Borrower) and reimbursement of expenses.


 


(c)          
Any payment due under this Note which is paid by check or draft shall be subject to the condition that any receipt issued
therefore shall be ineffective unless and until the amount due is actually received by Bank. Each payment received by Bank
shall be applied as follows: first, to the payment of any and all costs, fees and expenses incurred by or payable to
Bank in connection with the collection or enforcement of this Note; second, to the payment of all unpaid late charges
(if any); third, to the payment of all accrued and unpaid interest hereunder; and fourth, to the payment of the
unpaid principal balance of this Note, or in any other manner which Bank may, in its sole discretion, elect from time to
time.


 



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		7.	Security Interest in Collateral.



 


(a)          
To secure payment to Bank and performance of the Obligations, Borrower hereby grants to Bank a continuing security interest
in, a general lien upon and a right of set-off against the Collateral.


  


(b)          
Borrower hereby authorizes Bank, at any time and from time to time, to file financing statements, continuation statements
and amendments thereto under the Uniform Commercial Code naming Borrower as debtor and Bank as secured party and indicating therein
the types or describing the items of Collateral herein specified. Borrower will not, without the prior written consent of Bank,
file or authorize or permit to be filed in any jurisdiction any such financing or like statement in which Bank is not named as
the sole secured party covering the Collateral set forth herein.


  


(c)          
Following the occurrence and during the continuation of an Event of Default, Bank, at its discretion may, in its name or in
the name of Borrower or otherwise, demand, sue for, collect or receive any money or property at any time payable or
receivable on account of or in exchange for, or make any compromise or settlement deemed desirable with respect to, any of
the Collateral, but shall be under no obligation so to do, or Bank may extend the time of payment, arrange for payment in
installments, or otherwise modify the terms of, or release, any of the Collateral, without thereby incurring responsibility
to, or discharging or otherwise affecting any liability of Borrower. Bank shall not be required to take any steps necessary
to preserve any rights of prior parties to any of the Collateral. Upon default hereunder or in connection with any of the
Obligations (whether such default be that of Borrower or of any other party obligated thereon), Bank shall have the rights
and remedies provided by law. Borrower will pay to Bank all reasonable out of pocket expenses (including reasonable expense
for legal services of every kind) of, or incidental to, the enforcement of any of the provisions hereof or of any of the
Obligations, or any enforcement, collection, compromise or settlement of any of the Collateral or receipt of the proceeds
thereof, and for the care of the Collateral and defending or asserting the rights and claims of Bank in respect thereof, by
litigation or otherwise, including expense of insurance, and all such expenses shall be indebtedness within the terms of this
Note. Bank, shall apply the net cash receipts from the Collateral resulting from an enforcement action following an Event of
Default to the payment of principal of and/or interest on any of the Obligations making
proper rebate of interest or discount. Notwithstanding that Bank, whether in its own behalf and/or in behalf of another
and/or of others, may continue to hold Collateral and regardless of the value thereof, Borrower shall be and remain liable
for the payment in full, principal and interest, of any balance of the Obligations and expenses at any time unpaid. 


 


           8.   
Right of Set-Off. To secure payment of this Note and all other Obligations of Borrower to Bank, Borrower
and any Obligor of this Note hereby grant Bank a continuing lien and/or right of set-off upon any and all deposit and/or operating
accounts now or hereafter maintained with Bank, any and all securities and other property of Borrower and any Obligor and the proceeds
thereof now or hereafter coming into the possession or control of Bank, hereby authorizing Bank, following
the occurrence and during the continuation of an Event of Default to appropriate and apply such
deposits or the proceeds of the sale of such securities or other property to any such Obligations, it being understood that Bank
shall be under no obligation to effect any such appropriation and application.


 






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           9.   
Repayment Extension. If any payment of principal or interest shall be due on a Saturday, Sunday or any other
day on which banking institutions in the State of New York are required or permitted to be closed, such payment shall be made on
the next succeeding Business Day, and such extension of time shall in such case be included in the computation of the payment of
interest.


  


           10.
Late Charge. Borrower shall unconditionally pay to Bank a late charge (the “Late Charge”)
equal to the greater of (a) five (5%) percent of the payment then due or (b) $200.00, if any such payment in whole or in part is
not received by Bank within ten (10) days after its due date. The Late Charge is in addition to the Default Interest Rate, if applicable,
and shall be payable together with the next payment due hereunder or, at Bank’s option, upon demand by Bank, provided, however,
that if any such Late Charge is not recognized as liquidated damages for such delinquency, and if deemed to be interest in excess
of the amount permitted by applicable law, Bank shall be entitled to collect a Late Charge only at the highest rate permitted by
law, and any payment actually collected by Bank in excess of such lawful amount shall be deemed a payment in reduction of the principal
sum then outstanding, and shall be so applied.


  


		11.	Representations and Warranties. Borrower
represents and warrants to Bank that:



 


Existence and Qualification; Power
- Borrower is a corporation or limited liability company duly formed, validly existing and in good standing under the laws of the
state of its organization. Borrower is duly qualified or registered to transact business and is in good standing in each jurisdiction
in which the conduct of its business or the ownership or leasing of its properties makes such qualification or registration necessary.
Borrower has all requisite corporate power and/or other authority to conduct its business, to own and lease its properties and
to execute and deliver this Note and each Loan Document to which it is a party and to perform its Obligations;


 


Compliance with Laws - Borrower is
in compliance in all material respects with all laws, regulations and other legal requirements
applicable to its business, has obtained all authorizations, consents, approvals, orders, licenses and permits from, and has accomplished
(or obtained exemptions from) all filings, registrations and qualifications that are necessary for the transaction of its business;


  


Authority; Compliance With Other Agreements
and Instruments - the execution, delivery and performance by Borrower of this Note and the other Loan Documents to which it
is a party has been duly authorized by all necessary corporate, partnership or membership action, as applicable, and does not and
will not: (i) require any consent or approval not heretofore obtained of any manager, director, stockholder, member, partner, security
holder or creditor of such party; (ii) violate or conflict with any provision of Borrower’s partnership agreement, articles
of organization, operating agreement, articles of incorporation, charter, by-laws or other comparable instruments; or (iii) result
in a breach by Borrower or constitute a default by Borrower under, or cause or permit the acceleration of any obligation owed under,
any indenture or loan or credit agreement or any other contractual obligation to which Borrower is a party or by which Borrower
or any of its property is bound or affected; 


  


Financial Statements - the financial
statements of Borrower previously furnished to Bank are complete and correct and fairly present the financial condition of Borrower,
as of the respective dates thereof and the results of Borrower’s operations as of the end
of the most recent fiscal quarter reflect no material adverse change in the financial condition of Borrower; 


 






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No Default - no event has occurred
and no event is continuing which with the giving of notice or the lapse of time or both would constitute an Event of Default;



  


Representations and Warranties -
prior to the making of each Advance all representations and warranties contained herein, or the other Loan Documents, shall be
true and correct and of the same force and effect as though such representations and warranties had been made as of the date of
the making of such Advance; 


  


Regulations T, U and X; Investment Company
Act - no part of the proceeds of the Loan will be used to purchase or carry, or to extend credit to others for the purpose
of purchasing or carrying, any margin stock within the meaning of Regulations T, U or X of the Board of Governors of the Federal
Reserve System. As of the date of this Note, Borrower is not or is not required to be registered as an “investment company”
under the Investment Company Act of 1940; and


  


Government Regulation - Borrower
is not involved in any activity, directly or indirectly, which would constitute a violation of applicable laws concerning money
laundering, the funding of terrorism or similar activities. No part of the proceeds of the Loan will be used to fund activities
which would constitute a violation of the United States Bank Secrecy Act, the United States Money Laundering Control Act of 1986,
the United States International Money Laundering Abatement and Anti-terrorist Financing Act of 2001. Borrower is not subject to
and shall not become subject at any time to any laws, regulation, or list of any government agency (including, without limitation,
the U.S. Office of Foreign Assets Control List) that prohibits or limits Bank from making any advance or extension of credit to
Borrower or from otherwise conducting business with Borrower. Borrower shall not fail to provide documentary or other evidence
of Borrower’s identity as may be requested by Bank at any time to enable Bank to verify Borrower’s identity or to comply
with any applicable law or regulation, including without limitation, Paragraph 326 of the USA Patriot Act of 2001, 31 U.S.C., Paragraph
5318. 


  


           12.
Events of Default. The occurrence of any one or more of the following events shall constitute an “Event
of Default” under this Note:


  


Payments – if Borrower, or
any other Obligor, fails to make any payment of principal or interest under the Obligations when such payment is due and payable;
or


  


Other Charges - if Borrower, or any
other Obligor, fails to pay any other charges, fees, expenses or other monetary obligations owing to Bank arising out of or incurred
in connection with this Note within five (5) Business Days after the date such payment is due and payable; or


  


Particular Covenant Defaults - if
Borrower fails to perform, comply with or observe any covenant or undertaking contained in any Loan Document and such failure continues
for ten (10) Days after the occurrence thereof; or


  


Financial Information – if
any statement, report, financial statement, or certificate made or delivered by Borrower, or any other Obligor, to Bank is not
true and correct in all material respects when made or delivered. 


  






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Warranties or Representations - if
any warranty, representation or other statement by or on behalf of Borrower contained in or pursuant to this Note, the other Loan
Documents or in any document, agreement or instrument furnished in compliance with, relating to, or in reference to this Note,
is false, erroneous, or misleading in any material respect when made; or


  


Agreements with Others - (i) if Borrower
shall default beyond any grace period in the payment of principal or interest of any Indebtedness of Borrower in excess of $250,000;
or (ii) if Borrower otherwise defaults under the terms of any such Indebtedness if the effect of
such default is to enable the holder of such Indebtedness to accelerate the payment of Borrower’s obligations, which are
the subject thereof, prior to the maturity date or prior to the regularly scheduled date of payment, and such default is not waived
by the holder thereof ; or


  


Other Agreements with Bank - if any
Obligor breaches or violates the terms of, or if a default occurs under, any other existing or future agreement (related or unrelated)
(including, without limitation, the other Loan Documents) between Borrower and Bank and such breach,
violation or default is not cured within ten (10) days after Bank provides notice thereof to Borrower; or


 


Judgments - if any final judgment
exceeding $250,000 for the payment of money (i) which is not fully and unconditionally covered
by insurance or (ii) for which Borrower has not established a cash or cash equivalent reserve in the full amount of such judgment,
shall be rendered by a court of record against Borrower and such judgment shall continue unsatisfied and in effect for a period
of thirty (30) consecutive days without being vacated, discharged, satisfied or bonded pending appeal; or


  


Assignment for Benefit of Creditors,
etc. - if Borrower makes or proposes in writing, an assignment for the benefit of creditors generally, offers a composition
or extension to creditors, or makes or sends notice of an intended bulk sale of any business or assets now or hereafter owned or
conducted by Borrower; or


  


Bankruptcy, Dissolution, etc. - upon
the commencement of any action for the dissolution or liquidation of Borrower, or the commencement of any proceeding to avoid any
transaction entered into by Borrower, or the commencement of any case or proceeding for reorganization or liquidation of Borrower’s
debts under the Bankruptcy Code or any other state or federal law, now or hereafter enacted for the relief of debtors, whether
instituted by or against Borrower; provided however, that Borrower shall have twenty (20) Business Days to obtain the dismissal
or discharge of involuntary proceedings filed against it, it being understood that during such twenty (20) Business Day period,
Bank may seek adequate protection in any bankruptcy proceeding; or


  


Receiver - upon the appointment of
a receiver, liquidator, custodian, trustee or similar official or fiduciary for Borrower or for Borrower’s property; or


  


Execution Process, etc. - the issuance
of any execution or distraint process against any property of Borrower; or


  






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Investigations - any indication or
evidence received by Bank that reasonably leads it to believe Borrower may have directly or indirectly been engaged in any type
of activity which, would be reasonably likely to result in the forfeiture of any material property of Borrower to any governmental
entity, federal, state or local; or


  


Liens - if any lien in favor of Bank
shall cease to be valid, enforceable and perfected and prior to all other liens other than permitted liens; or


  


Fraudulent Conveyance - the making
or suffering by Borrower, or any other Obligor, of a transfer of any property, which is judicially
determined to be fraudulent under the law of any applicable jurisdiction; or


  


Material Adverse Effect – if
there is any change in Borrower’s financial condition which, in Bank’s reasonable opinion, has or would be reasonably
likely to have a material adverse effect with respect to (a) the assets, properties, financial condition, credit worthiness, business
prospects, material agreements or results of business operations of Borrower, or (b) Borrower’s ability to pay the Obligations
in accordance with the terms hereof, or (c) the validity or enforceability of this Note or any of the other Loan Documents or the
rights and remedies of Bank hereunder or thereunder.


  


           13. Rights and Remedies upon Default.
Following the occurrence of an Event of Default hereunder, Bank, in Bank’s sole discretion and without notice or demand to
Borrower or any other Obligor, may: (a) declare the entire outstanding principal balance of this Note, together with all accrued
interest and all other sums due under this Note to be immediately due and payable, and the same shall thereupon become immediately
due and payable without presentment, demand or notice, which are hereby expressly waived (b) exercise its right of set-off against
any money, funds, credits or other property of any nature whatsoever of Borrower or any other Obligor now or at any time hereafter
in the possession of, in transit to or from, under the control or custody of, or on deposit with, Bank or any affiliate of Bank
in any capacity whatsoever, including without limitation, any balance of any deposit account and any credits with Bank or any affiliate
of Bank; (c) terminate any outstanding commitments of Bank to Borrower or any Obligor; (d) liquidate the Collateral Account and
apply all or a portion of the proceeds of the Collateral Account in reduction of the Obligations, whether or not such Collateral
Deposit is matured or unmatured, and the Bank shall not be liable or in any way responsible to the Borrower by reason of any early
withdrawal or similar penalties or charges imposed in connection therewith; and (e) exercise any or all rights, powers, and remedies
provided for in the Loan Documents or now or hereafter existing at law, in equity, by statute or otherwise.


 


           14. Remedies Cumulative. Each right,
power and remedy of Bank hereunder, under the other Loan Documents or now or hereafter existing at law, in equity, by statute or
otherwise shall be cumulative and concurrent, and the exercise or the beginning of the exercise of any one or more of them shall
not preclude the simultaneous or later exercise by Bank of any or all such other rights, powers or remedies. No failure or delay
by Bank to insist upon the strict performance of any one or more provisions of this Note or of the Loan Documents or to exercise
any right, power or remedy consequent upon a breach thereof or a default hereunder shall constitute a waiver thereof, or preclude
Bank from exercising any such other rights, powers or remedy. By accepting full or partial payment after the due date of any amount
of principal or interest on this Note, or other amounts payable on demand, Bank shall not be deemed to have waived the right either
to require prompt payment when due and payable of all other amounts of principal or interest on this Note or other amounts payable
on demand, or to exercise any rights and remedies available to is in order to collect all such other amounts due and payable under
this Note.


 






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		15.	Intentionally Omitted



 


		16.	Intentionally Omitted



 


           17. Additional Costs. If, as a
result of any change in applicable law, regulation, guideline or order, or in the interpretation or application thereof by any
governmental authority charged with the administration thereof, there shall be imposed upon or made applicable to Bank any reserve
requirement against this Note or any other costs or assessments (hereinafter “Additional Costs”), Borrower shall pay
to Bank, on demand (which demand shall be in writing and which will set forth a calculation of such Additional Costs), an amount
sufficient to compensate Bank for such Additional Cost. Bank’s calculation of the amount of such Additional Costs shall be
presumed correct absent manifest error.


 


           18. Taxes. Any and all payments
by or on account of any Obligations hereunder shall be made free and clear of and without deduction for any taxes; provided that
if the Borrower shall be required to deduct any taxes from such payments, then (i) the sum payable shall be increased as necessary
so that after making all required deductions (including deductions applicable to additional sums payable under this paragraph but
excluding any deductions made for taxes upon Bank’s net income or franchise taxes payable
by Bank) the Bank (as the case may be) receives an amount equal to the sum it would have received had no such deductions been made,
(ii) the Borrower shall make such deductions and (iii) the Borrower shall pay the full amount deducted to the relevant governmental
authority in accordance with applicable law.


 


           19. Collection Expenses. If this
Note is placed in the hands of an attorney for collection following the occurrence of an Event of Default hereunder, Borrower agrees
to pay to Bank upon demand costs and expenses, including all reasonable attorney’s fees and
court costs, paid or incurred by Bank in connection with the enforcement or collection of this Note (whether or not any action
has been commenced by Bank to enforce or collect this Note) or in successfully defending any counterclaim or other legal proceeding
brought by Borrower contesting Bank’s right to collect the outstanding principal balance of this Note. The obligation of
Borrower to pay all such costs and expenses shall not be merged into any judgment by confession against Borrower. All of such costs
and expenses shall bear interest at the highest rate of Interest permitted under this Note from the date of payment by Bank until
repaid in full.


 


           20. Interest Rate after Judgment.
If judgment is entered against Borrower on this Note, the amount of the judgment entered (which may include principal, interest,
fees and costs) shall bear interest at the higher of (i) the legal rate of interest then applicable to judgments in the jurisdiction
in which judgment was entered, or (ii) if otherwise permitted by applicable law, the Default Interest Rate provided herein.


 


           21. Certain
Waivers by Borrower. Borrower waives demand, presentment, protest and notice of demand, of non-payment, of dishonor,
and of protest of this Note. Bank, without notice to or further consent of Borrower or any other Obligor and without in any
respect compromising, impairing, releasing, lessening or affecting the obligations of Borrower hereunder or under of the Loan
Documents, may: (a) release, surrender, waive, add, substitute, settle, exchange, compromise, modify, extend or grant
indulgences with respect to (i) this Note, (ii) any of the Loan Documents, and/or (iii) all or any part of any Collateral or
security for this Note; and/or (iv) any Obligor; (b) complete any blank space in this Note according to the terms upon which
the Loan evidenced hereby is made; and (c) grant any extension or other postponements of the time of payment hereof.


 






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           22. Choice of Law: Forum Selection: Consent
to Jurisdiction. This Note shall be governed by, construed and interpreted in accordance with the laws of the State of
New York (excluding the choice of law rules thereof). Borrower hereby irrevocably submits to the jurisdiction of any New York court
or federal court sitting in the State of New York in any action or proceeding arising out of or relating to this Note, and hereby
irrevocably waives any objection to the laying of venue of any such action or proceeding in any such court and any claim that any
such action or proceeding has been brought in an inconvenient forum. A final judgment in any such action or proceeding shall be
conclusive and may be enforced in any other jurisdiction by suit on the judgment or in any other manner provided by law.


 


           23. Subsequent Holders. In the
event that any holder of this Note transfers this Note for value, Borrower agrees that except with respect to a subsequent holder
with actual knowledge of a claim or defense, no subsequent holder of this Note shall be subject to any claims or defenses which
Borrower may have against a prior holder (which claims or defenses are not waived as to prior holder), all of which are waived
as to the subsequent holder, and that all such subsequent holders shall have all of the rights of a holder in due course with respect
to Borrower even though the subsequent holder may not qualify, under applicable law, absent this paragraph, as a holder in due
course.


 


           24. Invalidity of Any Part. If
any provision or part of any provision of this Note shall for any reason be held invalid, illegal or unenforceable in any respect,
such invalidity, illegality or unenforceability shall not affect any other provision (or any remaining part of any provision) of
this Note, and this Note shall be construed as if such invalid, illegal or unenforceable provision (or part thereof) had never
been contained in this Note, but only to the extent of its invalidity, illegality, or unenforceability. In any event, if any such
provision pertains to the repayment of the Obligations evidenced by this Note, then and in such event, at Bank’s option,
the outstanding principal balance of this Note, together with all accrued and unpaid interest thereon, shall become immediately
due and payable.


 


           25.
WAIVER OF JURY TRIAL. BORROWER HEREBY (i) COVENANTS AND AGREES NOT TO ELECT A TRIAL BY JURY OF ANY ISSUE
TRIABLE OF RIGHT BY A JURY, AND (ii) WAIVES TRIAL BY JURY IN ANY ACTION OR PROCEEDING TO WHICH BANK AND BORROWER MAY BE PARTIES
ARISING OUT OF, IN CONNECTION WITH OR IN ANY WAY PERTAINING TO THIS NOTE, ANY OF THE LOAN DOCUMENTS AND/OR ANY TRANSACTIONS, OCCURRENCES,
COMMUNICATIONS, OR UNDERSTANDINGS (OR THE LACK OF ANY OF THE FOREGOING) RELATING IN ANY WAY TO BORROWER-BANK RELATIONSHIP BETWEEN
THE PARTIES. IT IS UNDERSTOOD AND AGREED THAT THIS WAIVER CONSTITUTES A WAIVER OF TRIAL BY JURY OF ALL CLAIMS AGAINST ALL PARTIES
TO SUCH ACTIONS OR PROCEEDINGS, INCLUDING CLAIMS AGAINST PARTIES WHO ARE NOT PARTIES TO THIS NOTE. THIS WAIVER OF JURY TRIAL IS
SEPARATELY GIVEN, KNOWINGLY, WILLINGLY AND VOLUNTARILY MADE BY BORROWER AND BORROWER HEREBY AGREES THAT NO REPRESENTATIONS OF
FACT OR OPINION HAVE BEEN MADE BY ANY INDIVIDUAL TO INDUCE THIS WAIVER OF TRIAL BY JURY OR TO IN ANY WAY MODIFY OR NULLIFY ITS
EFFECT. BANK IS HEREBY AUTHORIZED TO SUBMIT THIS NOTE TO ANY COURT HAVING JURISDICTION OVER THE SUBJECT MATTER AND BORROWER SO
AS TO SERVE AS CONCLUSIVE EVIDENCE OF SUCH WAIVER OF RIGHT TO TRIAL BY JURY. BORROWER REPRESENTS AND WARRANTS THAT IT HAS BEEN
REPRESENTED IN THE SIGNING OF THIS NOTE AND IN THE MAKING OF THIS WAIVER BY INDEPENDENT LEGAL COUNSEL, SELECTED OF ITS OWN FREE
WILL, AND/OR THAT IT HAS HAD THE OPPORTUNITY TO DISCUSS THIS WAIVER WITH COUNSEL.


 






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		26.	Intentionally Omitted.



 


           27. Indemnification. The
Borrower agrees: (i) to pay and reimburse Bank for all of its reasonable and documented out-of-pocket costs and expenses incurred
in connection with the preparation and execution of, and any amendment, supplement or modification to, this Note and the other
Loan Documents, and the consummation and administration of the transactions contemplated hereby and thereby, including the reasonable
fees, disbursements and other charges of internal and external counsel, (ii) to pay and reimburse Bank for reasonable and documented
out-of-pocket costs and expenses incurred in connection with the enforcement or preservation of any rights under this Note
and the other Loan Documents including the reasonable fees, disbursements and other charges of its counsel, whether internal
or external, (iii) to pay, indemnify and hold harmless the Bank and its directors, officers and agents (each, an “Indemnified
Party” and collectively, “Indemnified Parties”) from and against any and all other liabilities, obligations,
losses, damages, penalties, actions, judgments, suits, costs, expenses or disbursements of any kind or nature whatsoever, including
reasonable and documented fees, disbursements and other charges of internal or external counsel for all Indemnified Parties in
connection with the execution, delivery, enforcement, performance and administration of this Note or the Loan Documents or the
use of the proceeds thereof, including any of the foregoing relating to the violation of, noncompliance with or liability applicable
to the operations of the Borrower or any of its subsidiaries; provided that the Borrower shall have no obligation hereunder to
any Indemnified Party with respect to damages caused directly by the gross negligence or willful misconduct of such Indemnified
Party as determined by a non-appealable final judgment.


 


           28. Miscellaneous.
Time is of the essence under this Note. The paragraph headings of this Note are for convenience only, and shall not limit or
otherwise affect any of the terms hereof. This Note and the other Loan Documents, if any, constitute the entire agreement
between the parties with respect to their subject matter and supersede all prior letters, representations, or agreements,
oral or written, with respect thereto. No modification, release, or waiver of this Note shall be deemed to be made by Bank
unless in writing signed by Bank, and each such waiver, if any, shall apply only with respect to the specific
instance involved. No course of dealing or conduct shall be effective to modify, release or waive any provisions of this Note
or any of the other Loan Documents. Borrower acknowledges that this Note is an instrument for the payment of money only
within the meaning of Section 3213 of the New York Civil Practice Law & Rules. This Note shall inure to the benefit of
and be enforceable by Bank and Bank’s successors and assigns and any other person to whom Bank may grant an interest in
the obligations evidenced by this Note and shall be binding upon and enforceable against Borrower and Borrower’s
successors and assigns it being understood that Borrower may not assign this Note without the prior written consent of Bank.
Borrower agrees that Bank may at any time sell, assign, transfer, hypothecate or pledge one or more interests or
participations in all or any part of its rights and obligations in this Note. Whenever used herein, the singular number shall
include the plural, the plural the singular, and the use of the masculine, feminine, or neuter gender shall include all
genders.


 






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	Borrower: 	 
	 	 	 
	CORONADO BIOSCIENCES, INC.    	 
	 	 	 
	 	 	 
	By:	/s/ Lindsay Rosenwald	 
	Name: 	Lindsay Rosenwald	 
	Title:	CEO	 







 













 






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