ORIGINAL

TSCA NON-CONFIDENTIAL BUSINESS INFORMATION

DOCUMENT DESCRIPTION DOCUMENT CONTROIL NUMBER DATE RECEIVED

8EHQ-1 1- 9 88110000182 q 4 lit

COMMENTS:

DOES NOT CONTAIN CBI
Akzo Nobel Services Inc. 525 W Van Buren Street T +1 312 544 7000

Technology & Engineering Chicago, Illinois F +1 312 544 7125 4

RALS Americas 60607-3835 www.akzonobel.com/te

United States

AkzoNobel

11 N 11 11 11 E 1 Hil 111 111 11 1 To mnorovvs Answers Today

April 1, 2011

Off ice of Pollution Prevention and Toxics 77 ~rn

U.S. EPA 2

Attn: Section 8(e)

1201 Constitution Avenue, NW

Washington, DC 20004

Subject: TSCA 8(e) Notice

Dear U.S. EPA:

On behalf of Akzo Nobel Surface Chemistry LLC, we are submitting preliminary

results from an OECD 422 Reproduction/Developmental Toxicity Screening

Test on alkyl amidopropyl dimethyl amine, CAS# 68140-01 -2.

NOTE: This substance is considered corrosive to skin and eyes, and this

should be kept in mind when evaluating the results from the OECD 422 study.

In the OECD 422 study, groups of 10 male and 10 female rats were treated by

gavage once daily for up to 45 consecutive days (including a two week

maturation phase, pairing, gestation and early lacation for females). A Control

Group was dosed with the vehicle only (corn oil). The following dose levels

were selected as follows:

Control Group: 0 mg/kg body weight/day

Low Dose Group: 5 mg/kg body weight/day

Mid Dose Group: 15 mg/kg body weight/day

High Dose Group: 45 mg/kg body weight/day

The test substance did not induce any significant adverse effects on: (1) the

parental animals, (2) reproductive parameters, or, (3) the developing fetuses,

except for one finding in the parental animals. There were isolated

histopathology findings in the forestomnachs/stomachs of a number of treated

parental animals showing toxicity to the cellular lining. The cellular lining of the

forestomach/stomach came into direct contact with the corrosive test article

following oral administration.

~II ocoi ~ ~II 8CONTAINS i NO C81
AkzoNobel

Most of the reported histopathology effects were observed in the rat

forestomach. While not an unexpected finding for a corrosive substance

delivered orally to rats, toxicity to the forestomach/stomach lining was not

severe enough to be noticed during gross visual necropsy of the treated

animals, but was observed only under preliminary microscopic examination.

The human relevance of the findings in the non-glandular portion of the

stomach (forestomach) is not known because this organ while present in rats,

is not present in humans.

Please contact me if you have any questions at 312-544-7191.

Sincerely,

Edwin C. Bisinger Jr., rPhD, DABT

Director, Global Product Stewardship

Business Support/HSE Department

Akzo Nobel Services Inc.

525 W. Van Buren St.

Chicago, IL 60607-3835
Page 1 of 1

From. (312) 5447315 Origin ID: GYYA Slip Date: 01APR1I1

FRANK THORNE Ac(Wgt 0.5 LB

AI(ZO NOBEL SERVICES INC bu CAD, 331253Si'ET3 130

515 WEST VAN BUREN STREET

CHIAGO, IL 8007 IIiIII hI 1111IIIIII11111

SHIP TO: M22 564-8940 BILL SENDER Rf 21H2

DOCUMENT CONTROL OFFCR SECTO 8 Woke #

U.S. EPA - POLLUTION PRVNTN & TXCS "c' #

1201 CONSTITUTION AVE NW Dept #

WASHINGTON, DC 20480

MON -04 APR Al

S7969 4210 9187 STANDARD OVERNIGHT

20460

DC-US SA RDVA DCA

50DG3f26A&'7EFB

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costs, and other forms of damage whether direct, incidentalconsequential, or special is limited to the greater of $100 or the authorized declared value.

Recovery cannot exceed actual documented loss.Maximum for items of extraordinary value is $500, e.g. jewelry, precious metals, negotiable instruments and other items listed in our ServiceGuide. Written claims must be filed within strict time limits, see current FedlEx Service Guide.

https ://www.fedex.com/shipping/html/en//PrintIFrame.html 04/01/2011
Akzo Nobel Services Inc. 525 W Van Buren Street T +1 312 544 7000

Technology & Engineering Chicago, Illinois F +1 312 544 7125

RAILS Americas 60607-3835 www.akzonobel com/te

United States

AlzoNobeI

Tomnorrow's Answiers Today

April 1, 2011

-7o

Office of Pollution Prevention and Toxics

U.S. EPA

Attn: Section 8(e) ~-

1201 Constitution Avenue, NWWashington, DC 20004 C

Subject: TSCA 8(e) Notice

Dear U.S. EPA:

On behalf of Akzo Nobel Surface Chemistry LLC, we are submitting draft

results from an oral (gavage) fourteen day range-finding study in rats on alkyl

amidopropyl dimethyl amine, CAS# 68140-01-2.

This fourteen day range-finding study was performed to identify appropriate

dose levels for an OECD 422 Rep rod uction/Deve lopmental Toxicity Screening

Test.

NOTE: CAS# 68140-01 -2 is considered corrosive to skin and eyes, and this

should be kept in mind when evaluating the results from the fourteen day

range-finding study.

For the fourteen day range-finding groups of six rats (3M/3F) were dosed via

oral gavage at levels of 25, 50, or 100 mg/kg/day. One control group was

dosed with the vehicle only (corn oil).

With respect to clinical signs, animals in the 100 mg/kg/day group showed

increased salivation, noisy respiration and reduced body weight gain. The 50

mg/kg/day group showed reduced body weight gain.

At necropsy, some animals in the 100 mg/kg/day and 50 mg/kg/day groups

showed thickening of the non-glandular (forestomnach) region of the stomach.

One male in the 25 mg/kg/day group showed this same effect.

A AMS. N O CB1
AlizoNobel

The necropsy findings are not unexpected following oral dosing of a skin

corrosive test article to rats because the corrosive test article would come into

direct contact with the forestomnach. Further, the human relevance of the

findings in the non-glandular portion of the stomach (forestomach) is not known

because this organ while present in rats, is not present in humans.

Please contact me if you have any questions at 312-544-7191.

Sincerely,

Edwin C. Bisinger Jr., PD, DABT

Director, Global Product Stewardship

Business Support/HSE Department

Akzo Nobel Services Inc.

525 W. Van Buren St.

Chicago, IL 60607-3835
Page 1 of 1

From: (312) 544-7315 OrignD. GYYA Fe I K Ship Date: 0 1APR 11

FRANK TH-ORNE ActWgt 0.5 LB

WKO NOBEL SERVICES INC &4v-s CAa) 3312538ANET3130

525*WEST VAN BUREN STREET

Delivery Address Bar Code

CHICAGO, IL 60607 J I

SHIP TO: (202) 564-8948 BILL SENDER Ref# 7201SH526

DOCUMENT CONTROL OFFCR SECTION 8(q invoice#

U.S. EPA - POLLUTION PRVNTN & TXCS PO #

1201 CONSTITUTION AVE NW Dept #

WASHINGTON, DC 2040____________ _________

MON -04 APR Al

"*7948 04016184 STANDARD OVERNIGHT

V 20460

SA DlA DC-u

51OG326A8/7EFB

After printing this label:

1. Use the 'Print' button on this page to print your label to your laser or inkjet printer.

2. Fold the printed page along the horizontal line.

3. Place label in shipping pouch and affix it to your shipment so that the barcode portion of the label can be read and scanned.

4Varning Use only tile pinited or igln~il s - i rg of~*~y. thiis label ior shiping pLurPOSeS IS 'rI L..i nt aod cld

resuit In additional billing charges,longnrF ,it li-' - .<~cFount ac nulba r

Use of this system constitutes your agreement to the service conditions in the current FedEx Service Guide, available on fedexcom.FedEx will not be

responsible for any claim in excess of $100 per package, whether the result of loss, damege, delay, non-delivery,misdelivery,or misinformation, unless

you declare a higher value, pay an additional charge, document your actual loss and file a timely claim.Limitations found in the current FedEx Service

Guide apply. Your right to recover from FedEx for any loss, including intrinsic valueof the package, loss of sales, income interest, profit, attorney's fees,

costs, and other forms of damage whether direct, incidentalconsequential, or special is limited to the greater of $100 or the authorized declared value.

Recovery cannot exceed actual documented loss.Maximum for items of extraordinary value is $500, e.g. jewelry, precious metals, negotiable instruments and other items listed in our ServiceGuide. Written claims must be filed within strict time limits, see current FedEx Service Guide.

https://www.fedex.com/shipping/html/en//PrintIFrame.html 04/01/2011