Exhibit 10.1




 


Second
Amendment to Commercial Lease


 


The Parties hereto, Clematis LLC, (“LESSOR”)
and Interleukin Genetics, Inc., (“LESSEE”) are Parties under a certain Commercial Lease (“Lease Agreement”)
dated February 13, 2004 and a First Amendment to Commercial Lease (“First Amendment”) dated November 18, 2008, for
approximately 19,000 rentable square feet on the third floor at 135 Beaver Street, Waltham, MA and hereby agree as follows (“Leased
Premises”):


 


Whereas, the Parties have agreed to amend
the Lease Agreement and the First Amendment by this Second Amendment to the Commercial Lease (“Second Amendment”) to
extend the Term of the Lease Agreement, surrender approximately 6,011 rentable square feet, and to adjust relevant provisions of
the Lease Agreement pursuant to the terms and conditions stated herein. Unless otherwise expressly stated, all references to “lease”
or “Lease” shall apply to and include the Lease Agreement, the First Amendment and this Second Amendment. Unless otherwise
expressly stated, all references to “leased premises” or “Leased Premises” shall apply to and include the
approximately 13,000 rentable square feet on the third floor at 135 Beaver Street, Waltham, MA.


 


Now therefore, for mutual consideration,
the receipt of which is hereby acknowledged by both parties, effective on and after the date this Second Amendment is fully executed
by both Parties the Lease Agreement is hereby amended to reflect the following changes:


 


		2.	PREMISES:



This paragraph is hereby
deleted and replaced with the following:


 


12,989 square feet +/- on the
third floor of 135 Beaver Street, Waltham, MA 02452. Together with the right to use in common, with others entitled hereto, the
hallways, stairways and elevators necessary for access to said Leased Premises, and lavatories nearest thereto, as well as the
non-exclusive use of forty six (46) parking spaces serving the building.


 


		3.	TERM:



This paragraph is hereby
deleted and replaced with the following:


 


The Initial Term of this lease
shall be for five (5) years commencing on April 1, 2004, and ending on March 31, 2009. The First Extended Term of this lease shall
be for five (5) years commencing on April 1, 2009 and ending on March 31, 2014. The Second Extended Term of this Lease shall be
for three (3) years commencing on April 1, 2014 and ending on March 31, 2017. Unless otherwise expressly stated, all references
to “Term” or “term” shall apply to and include the Initial Term the First Extended Term and the Second
Extended Term.


 


		4.	RENT:



This paragraph is
hereby amended with the addition of the following:


 




  During the Second Extended Term, the LESSEE shall pay to the LESSOR base rent in accordance with the schedule noted below per year, payable in advance in monthly installments in accordance with the schedule noted below commencing April 1, 2014. During the Second Extended Term, LESSEE shall pay base rent and additional rent to the LESSOR monthly, in advance, not later than the first day of each calendar month. Payments shall be pro rated on a per diem basis should any payment become due during a portion of any monthly rental period.


 






    	 



    	 



    

 


	Base Rent:	 	 	 	 	 	 	 	 	 
	Year	 	PRSF	 	 	Monthly	 	 	Yearly	 
	4/1/14-3/31/15	 	$	24.25	 	 	$	26,248.60	 	 	$	314,983.25	 
	4/1/15-3/31/16	 	$	24.75	 	 	$	26,789.81	 	 	$	321,477.75	 
	4/1/16-3/31/17	 	$	25.25	 	 	$	27,331.02	 	 	$	327,972.25	 





 


		6.	RENT ADJUSTMENT:



The following paragraphs
are hereby amended with the addition of the following:


 




A. TAX ESCALATION: During
the Second Extended Term, if for any tax year commencing with the fiscal year ending June 30, 2014 (July 1, 2013- June 30, 2014),
the real estate taxes on the land and buildings, of which the Leased Premises are a part, are in excess of the amount of the real
estate taxes thereon for the fiscal year ending June 30, 2013 (July 1, 2012 - June 30, 2013) (hereinafter called the "Second
Extended Term Base Year"), LESSEE will pay to LESSOR as additional rent hereunder, when and as designated by notice in writing
by LESSOR, 13.54 percent of such excess that may occur in each year of the Extended Term of this lease or any extension or renewal
thereof and proportionately for any part of a fiscal year. If the LESSOR obtains an abatement of any such excess real estate tax,
a proportionate share of such abatement, less the reasonable fees and costs incurred in obtaining the same, if any, shall be refunded
to the LESSEE. The LESSEE shall, effective July 1, 2013, make estimated installment payments as additional rent as and when the
payment of base rent is due. During the fiscal year ending June 30, 2014 the LESSEE’S estimated installment payments shall
be 105% of the actual real estate taxes assessed during the fiscal year ending June 30, 2013 less the Second Extended Term Base
Year amount. Thereafter, estimated real estate tax payments shall be based on 105% of the prior year’s actual real estate
taxes less the Second Extended Term Base Year amount. Actual real estate taxes will not be known at the beginning of each fiscal
year and therefore retroactive adjustment to estimated payments shall be necessary when actual real estate taxes are known. After
the end of each fiscal year, as and when the actual real estate taxes are available, LESSOR shall provide LESSEE written notice
in reasonable detail of LESSEE’S pro rata share of the actual real estate taxes for such fiscal year less the Extended Term
Base Year amount, the estimated payments made by LESSEE on account thereof, and the new estimated payments calculated in accordance
with the above. The LESSEE shall pay LESSOR within thirty (30) days of receiving such written notice, the balance owed due to
insufficient estimated payments made in accordance with the above, and the LESSOR shall credit the LESSEE’S account for
any excess estimated payments made in accordance with the above, or, in the event the lease has expired and no money is owed on
the account of LESSEE, refund such excess to LESSEE.


 




  LESSEE percent of expense is calculated as follows: Leased Premises 12,989 rentable square feet, divided by total building 95,989 rentable square feet equals 13.53%.




 


			B. OPERATING COST ESCALATION: During the Second Extended Term, the LESSEE shall pay to the
LESSOR as additional rent hereunder when and as designated by notice in writing by LESSOR, 13.53% of any increase in operating
expenses over those incurred during the calendar year 2013. Operating expenses are defined for the purposes of this agreement in
Exhibit E. The LESSEE shall, effective January 1, 2014, make estimated installment payments as additional rent as and when the
payment of base rent is due. Operating expenses for any partial calendar year during the Second Extended Term will be prorated.
During the calendar year 2014, the LESSEE’S estimated installment payments shall be 105% of actual operating expenses assessed
during calendar year 2013 less the operating expenses base year amount for the Second Extended Term. Thereafter, estimated operating
expenses shall be based on 105% of the prior year’s actual operating expenses less the operating expenses base year amount
for the Second Extended Term. Actual operating expenses will not be known until after the conclusion of each calendar year, retroactive
adjustment to estimated payments shall be necessary when actual operating expenses are known. After the end of each calendar year,
as and when the actual operating expenses are available, LESSOR shall provide LESSEE written notice in reasonable detail of LESSEE’S
pro rata share of the actual operating expenses for such calendar year less the operating expenses base year amount for the Second
Extended Term, the estimated payments made by LESSEE on account thereof, and the new estimated payments calculated in accordance
with the above. The LESSEE shall pay LESSOR, within thirty (30) days of receiving written notice thereof, the balance owed due
to insufficient estimated payments made in accordance with the above, and the LESSOR shall credit the LESSEE’S account for
any excess estimated payments made in accordance with the above, or, in the event the lease has expired and no money is owed on
the account of LESSEE, refund such excess to LESSEE.



 






    	 



    	 



    

 


			LESSEE percent of real estate tax escalation and operating cost escalation is calculated as follows:
Leased Premises 12,989 rentable square feet, divided by total building 95,989 rentable square feet equals 13.53%.



 


			Increases shall be prorated should this lease be in effect with respect to only a portion of any
calendar year.



 


Notwithstanding anything herein
to the contrary, nothing in this Second Amendment shall release or waive any obligations of the LESSEE under the Initial Lease
or First Amendment to pay real estate tax escalations and operating cost escalations which accrue prior to April 1, 2014.


 


		21.	SURRENDER:



This first paragraph
is hereby deleted and replaced with the following:


 


			The LESSEE shall at the partial surrender of any portion of the Leased Premises, the expiration
or other termination of this lease remove all LESSEE's goods and effects from the Leased Premises, (including, without hereby limiting
the generality of the foregoing, all signs and lettering affixed or painted by the LESSEE, either inside or outside the leased
premises). LESSEE shall deliver to the LESSOR the Leased Premises and all keys, locks thereto, and other fixtures connected therewith
and all alterations and additions made to or upon the Leased Premises, in good condition, damage by fire or other casualty only
excepted. In the area used as a laboratory, good condition shall include the professional cleaning at LESSEE’S expense of
the Leased Premises including but not limited to any fixtures and HVAC units connected solely to the laboratory. In the event of
the LESSEE’S failure to remove any of LESSEE's property from the premises upon the expiration or other termination of the
lease, LESSOR is hereby authorized, without liability to LESSEE for loss or damage thereto, and at the sole risk of LESSEE, to
remove and store any of the property at LESSEE's expense, or to retain same under LESSOR's control or to sell at public or private
sale, without notice any or all of the property not so removed and to apply the net proceeds of such sale to the payment of any
sum due hereunder, or to destroy such property.



 






    	 



    	 



    

 


		23.	BROKERAGE:



This paragraph is hereby
amended with the addition of the following:


 


LESSOR and LESSEE represent to
each other that neither party has dealt with any broker, or any other person, in connection with showing the property or Leased
Premises for the Extended Term or this Second Amendment. LESSOR and LESSEE agree that each will hold harmless and indemnify the
other from any loss, costs, damage and expense, including reasonable attorney’s fees incurred by LESSOR or LESSEE for a commission
or finder’s fee as a result of the falseness of this representation.


 


		24.	OTHER PROVISIONS:



This paragraph is hereby
deleted and replaced with the following:


 


It is also understood and agreed
that the following items which are attached to either the Lease Agreement, the First Amendment or this Second Amendment are part
of this agreement and all other Exhibits or items previously contained in this paragraph are hereby deleted.


		·	Addendum



		·	Second Amendment Exhibit B-2 – LESSOR’S Work



		·	Exhibit C – Building Rules and Regulations



		·	Exhibit D – Description of Premises on which Leased Premises are located



		·	Exhibit E – Building Operating Expenses



		·	Exhibit F – Cleaning Schedules



 


The Lease Agreement is further
amended with the addition of the following paragraph:


 


		25.	OPTION TO EXTEND:



This paragraph from the First
Amendment is hereby deleted and replaced with the following:


 


Provided the LESSEE is not in
default hereunder, LESSEE shall have one (1) two (2) year option to extend the lease term at a rent equal to the greater of the
following: (a) market rate for equivalent office space in similarly located buildings within the Waltham market as determined by
LESSOR; or (b) the total rent then in effect as of the expiration date of the then current lease term. In no event shall the rent
for the option term be less than the total rent then in effect as of the expiration date of the then current lease term. LESSEE
must give LESSOR written notice it is exercising its extension option no later than nine (9) months prior to the expiration of
the then current lease term (“Extension Notice”). LESSOR shall provide LESSEE with the rent rate for the extended term
within thirty (30) days of receiving the Extension Notice. In the event LESSEE notifies LESSOR as provided herein and, within thirty
(30) days of receiving the LESSOR’S rent rate for the extended term has, in accordance with this paragraph, (i) delivered
a fully executed mutually agreeable lease amendment, (ii) updated all deposits, and (iii) tendered the first month’s base
rent for the extended term, then the Lease Agreement shall automatically be extended two (2) years from the date the Lease Agreement
would have expired had the option to extend not been exercised. All other terms and provisions under the Lease Agreement, other
than LESSOR’S Work or other tenant improvements, shall continue through the extended lease term. In the event the LESSEE
does not provide the Extension Notice, execute a lease amendment and provide payment as provided herein, the LESSEE shall be deemed
to have waived its option to extend the lease term and this Lease Agreement shall terminate upon the expiration of the then current
term.


 






    	 



    	 



    

 


Notwithstanding the above, LESSEE accepts
the Leased Premises in its current “AS IS” condition and acknowledges that the Leased Premises are currently occupied
by the LESSEE and that the Leased Premises, as delivered and currently constituted, is suitable for the LESSEE’S intended
use. LESSEE acknowledges that all work, if any, contemplated in the Lease Agreement, including but not limited to the Exhibit B
and Amendment Exhibit B-1 and this Second Amendment thereto, to be performed by the LESSOR has been completed to the full satisfaction
of the LESSEE.


 


The Parties acknowledge that the Lease
Agreement, the First Amendment, and this Second Amendment represent the entire agreement between the Parties and that no other
modification, written or otherwise, exists between the Parties. The normal rule of construction that any ambiguities be resolved
against the drafting party shall not apply to the interpretation of the Lease Agreement, the First Amendment or any exhibits or
amendments thereto.


 


All other terms and provisions under the
Lease Agreement shall remain unchanged and are hereby ratified and affirmed.


  


IN WITNESS WHEREOF, the said Parties hereto
set their hands and seals this 7th day of February, 2014.


 


	LESSEE	 	LESSOR
	Interleukin Genetics, Inc.	 	Clematis, LLC
	 	 	 	 	 
	By: 	 /s/ Eliot Lurier	 	By: 	/s/ Steven P. Duffy
	Name:	Eliot Lurier	 	 	  Steven P. Duffy
	Title: 	Chief Financial officer	 	 	  Duly Authorized
	Duly Authorized	 	 	 




 




    	 



    	 



    

 


SECOND AMENDMENT EXHIBIT B-2


LESSOR’S Work


 


LESSOR shall conduct the following LESSOR’S Work, using
building standard quantities and materials:


		1.	Paint the entire Leased Premises utilizing the same or substantially similar colors as present.
Any change in color shall be at LESSEE’S expense.



		2.	Carpet the Leased Premises using building standard carpet. LESSEE shall pack and crate its computer
equipment and personal belongings, etc. prior to the removal of old carpet and installation of new carpet. LESSOR shall in coordination
with carpet replacement, move and set back up the desks, chairs and file cabinets.



 


LESSEE acknowledges that the LESSOR’S
Work, or a portion thereof, may be conducted during normal business hours.


 


LESSEE shall be responsible for any delays,
costs and expenses caused by LESSEE’S failure, in a timely manner, to (i) do any work for which LESSEE is responsible; (ii)
prepare any area to be affected by the LESSOR’S Work by moving or adequately protecting any equipment, material and any other
item of the LESSEE, its employees, agents, assigns, vendors, customers or affiliates, which may be affected by the LESSOR’S
Work and the conduct thereof; (iii) make decisions affecting the LESSOR’S Work; (iv) reasonably accommodate and/or cooperate
with the execution or completion of LESSOR’S Work. LESSEE shall be solely responsible for all costs and expenses resulting
from requests by LESSEE for work, quantities or materials in excess of the LESSOR’S Work noted above.


 


Notwithstanding the above, LESSEE accepts
the Leased Premises in its current “AS IS” condition and acknowledges that the Leased Premises are currently occupied
and in the possession of the LESSEE and that the Leased Premises, as delivered and currently constituted, is suitable for the
LESSEE’S intended use. LESSEE acknowledges that all work contemplated in any prior Lease Agreement, Exhibit or Amendment
thereto to be performed by the LESSOR has been completed to the full satisfaction of the LESSEE.