Exhibit 10.14.1

FIRST AMENDMENT  TO  PREFERRED STOCK AND WARRANT PURCHASE AGREEMENT

This First Amendment to Preferred Stock and Warrant Purchase Agreement (the "Amendment") is made as of December 22, 2000 between
MedicaLogic/Medscape, Inc., an Oregon corporation (the "Company"), and the Investors listed on Schedule A hereto (the "Investors").

The
Company and the Investors are parties to a Preferred Stock and Warrant Purchase Agreement dated as of December 22, 2000 (the "Agreement"). The parties wish to amend the
Agreement to reflect the purchase of additional securities by one of the Investors.

NOW,
THEREFORE, the parties agree as follows:

1.  All
capitalized terms used herein and are defined herein shall have the meanings assigned to such terms in the Agreement.

2.  Section 2.5(a)
of the Agreement is amended and restated to read in its entirety as follows:



3.  Schedule A
to the Agreement is amended and restated to read in its entirety as attached asSchedule Ahereto.

4.  Exhibit A
to the Agreement is amended as follows:



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5.  The
first paragraph of Exhibit C to the Agreement is amended and restated to read in its entirety as follows:



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6.  Recital
G of Exhibit D to the Agreement is amended and restated to read in its entirety as follows:



7.  Except
as expressly modified by this Amendment, the Agreement remains in full force and effect as written.

8.  This
Amendment shall be governed by and construed under the laws of the state of Oregon.

9.  This
Amendment may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same
instrument.

(Signature
page follows.)

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IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date and years first written above.

| |  | MEDICALOGIC/MEDSCAPE, INC.     
| |  | -------------------------------
| |  | By:                            
| |  | QUANTUM INDUSTRIAL PARTNERS LDC
| |  | By:                            
| |  | SFM DOMESTIC INVESTMENTS LLC   
| |  | By:                            
| |  | RAM TRADING, LTD.              
| |  | By:                            

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SCHEDULE A    SCHEDULE OF INVESTORS

|Investor                                  |  | Number of
Shares of
Series 1
Preferred Stock |  | Number of
Warrants
Shares |  | Total Purchase
Price
|----------------------------------------- |  | -------------------------------------------- |  | ------------------------- |  | --------------------
|Quantum Industrial Partners LDC           |  | 1,666,666                                    |  | 1,274,509                 |  | $                   
|SFM Domestic Investments LLC              |  | 1,666,666                                    |  | 1,274,509                 |  |                     
|Halifax Fund LP                           |  | 333,333                                      |  | 254,902                   |  |                     
|Lagunitas Partners LP                     |  | 500,000                                      |  | 382,353                   |  |                     
|Gruber & McBaine International            |  | 166,667                                      |  | 127,451                   |  |                     
|Montrose Investments Ltd.                 |  | 666,667                                      |  | 509,804                   |  |                     
|Coleman Swenson Hoffman Booth IV, LP      |  | 333,333                                      |  | 254,902                   |  |                     
|Crosslink Crossover Fund III, LP          |  | 88,000                                       |  | 67,295                    |  |                     
|Offshore Crosslink Crossover Fund III, LP |  | 6,000                                        |  | 4,588                     |  |                     
|Delta Growth, LP                          |  | 6,000                                        |  | 4,588                     |  |                     
|RAM Trading, Ltd.                         |  | 333,333                                      |  | 254,902                   |  |                     
|Cranshire Capital                         |  | 166,667                                      |  | 127,451                   |  |                     
|TOTAL                                     |  | 5,933,332                                    |  | 4,537,254                 |  | $                   

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