EX-10.1



 EXHIBIT 10.1 

900 NORTH POINT PARKWAY 

ALPHARETTA, GEORGIA 30005 

OFFICE LEASE AGREEMENT 

BETWEEN 
 BRE/COH GA LLC, a
Delaware limited liability company 
 (“LANDLORD”) 

AND 
 CLEARSIDE BIOMEDICAL,
INC., a Delaware corporation 
 (“TENANT”) 







 OFFICE LEASE AGREEMENT 

THIS OFFICE LEASE AGREEMENT (this “Lease”) is made and entered into as of November 21, 2016, by and between BRE/COH
GA LLC, a Delaware limited liability company (“Landlord”) and CLEARSIDE BIOMEDICAL, INC., a Delaware corporation (“Tenant”). The following exhibits and attachments are incorporated into and made a part of
this Lease: Exhibit A-1 (Outline and Location of Premises), Exhibit A-2 (Outline and Location of Refusal Space), Exhibit A-3 (Outline and Location of Deferred Space), Exhibit B (Expenses and Taxes),
Exhibit C (Work Letter), Exhibit D (Commencement Letter), Exhibit E (Building Rules and Regulations), Exhibit F (Additional Provisions) and Exhibit G (Form of Letter of Credit). 

1. Basic Lease Information. 
  

	 	1.01	“Building” shall mean the building located at 900 North Point Parkway, Alpharetta, Georgia 30005, and commonly known as 900 North Point. “Rentable Square Footage of the Building” is
deemed to be 130,381 square feet. 

  

	 	1.02	“Premises” shall mean the area shown on Exhibit A-1 to this Lease. The Premises is located on the 2nd floor and known as suite 250. If
the Premises include one or more floors in their entirety, all corridors and restroom facilities located on such full floor(s) shall be considered part of the Premises. The “Rentable Square Footage of the Premises” is deemed to be
18,744 square feet. Landlord and Tenant stipulate and agree that the Rentable Square Footage of the Building and the Rentable Square Footage of the Premises are correct. 


 

	 	1.03	“Base Rent”: 

  

									
	 Months of Term
	  	Annual
Rate
Per Square
Foot	 	  	Monthly
Base Rent	 
	 Commencement Date – Last day of 12th
full calendar month of the Term
	  	$	22.50	  	  	$	35,145.00	  
	 First day of 13th full calendar month of the
Term - Last day of 24th full calendar month of the Term
	  	$	23.18	  	  	$	36,207.16	  
	 First day of 25th full calendar month of the
Term - Last day of 36th full calendar month of the Term
	  	$	23.88	  	  	$	37,300.56	  
	 First day of 37th full calendar month of the
Term - Last day of 48th full calendar month of the Term
	  	$	24.60	  	  	$	38,425.20	  
	 First day of 49th full calendar month of the
Term - Last day of 60th full calendar month of the Term
	  	$	25.34	  	  	$	39,581.08	  
	 First day of 61st full calendar month of the
Term - Last day of 72nd full calendar month of the Term
	  	$	26.10	  	  	$	40,768.20	  
	 First day of 73rd full calendar month of the
Term - Termination Date
	  	$	26.88	  	  	$	41,986.56	  

 Notwithstanding anything in this Section of the Lease to the contrary, so long as Tenant is not in Default
(as defined in Section 18) under this Lease, Tenant shall be entitled to an abatement of Base Rent in the amount of $35,145.00 per month for 6 consecutive full calendar months of the Term (as defined in Section 1.06),








 
beginning with the 1st full calendar month of the Term (the “Base Rent Abatement Period”). The total amount of Base Rent
abated during the Base Rent Abatement Period shall equal $210,870.00 (the “Abated Base Rent”). If Tenant Defaults at any time during the Term and fails to cure such Default within any applicable cure period under the Lease, all
Abated Base Rent shall immediately become due and payable. The payment by Tenant of the Abated Base Rent in the event of a Default shall not limit or affect any of Landlord’s other rights, pursuant to this Lease or at law or in equity. During
the Base Rent Abatement Period, only Base Rent shall be abated, and all Additional Rent and other costs and charges specified in this Lease shall remain as due and payable pursuant to the provisions of this Lease. Notwithstanding the foregoing, at
any time prior to or during the Base Rent Abatement Period, Landlord shall have the option to purchase, by check or wire transfer of available funds, all or any part (in whole-month increments only) of the remaining Abated Base Rent
(“Remaining Abated Base Rent Amount”), by providing Tenant with written notice (“Abated Base Rent Payment Notice”). The Abated Base Rent Payment Notice shall set forth the month(s) of abatement that Landlord elects
to purchase and the total portion of the Remaining Abated Base Rent Amount that Landlord elects to purchase (the “Purchase Amount”). The Purchase Amount to be paid by Landlord to Tenant shall be paid simultaneously with the giving
of the Abated Base Rent Payment Notice. Upon Landlord’s tender of the Purchase Amount, the Abated Base Rent shall be reduced by the number of months of Abated Base Rent so purchased by Landlord. Upon request by Landlord, Landlord and Tenant
shall enter into an amendment to the Lease to reflect the Purchase Amount paid by Landlord and the corresponding reduction of the Abated Base Rent. 
  

	 	1.04	“Tenant’s Pro Rata Share”: 14.3763%. 

  

	 	1.05	“Base Year”: 2017. 

  

	 	1.06	“Term”: The period commencing on the Commencement Date (defined below) and, unless terminated earlier in accordance with this Lease, ending on the last day of the 78th full calendar month following the Commencement Date (the “Termination Date”). The “Commencement Date” shall mean the date on which the Landlord Work (defined
in Section 1.14) is Substantially Complete (defined in Section 3). The parties anticipate that the Landlord Work will be Substantially Complete on or about March 1, 2017 (the “Target Commencement Date”).


  

	 	1.07	Allowance(s): an amount not to exceed $679,296.45, as further described in the attached Exhibit C. 

  

	 	1.08	“Security Deposit”: As of the date of this Lease, there is no Security Deposit. 

  

	 	1.09	“Guarantor”: As of the date of this Lease, there is no Guarantor. 

  

	 	1.10	“Broker(s)”: Lavista Associates, Inc. (“Tenant’s Broker”), which represented Tenant in connection with this transaction, and Lincoln Property Company (“Landlord’s
Broker”), which represented Landlord in connection with this transaction. 


  
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	 	1.11	“Permitted Use”: General office use, plus use of lab space for the sole purpose of conducting testing/engineering related to Tenant’s business, provided that such lab space use shall not exceed 10%
of the total square footage of the Premises (the “Lab Space”),and the use of such Lab Space shall be subject to the terms of this Lease. 

  

	 	1.12	“Notice Address(es)”: 

  

			
	Landlord:	  	Tenant:
		
	 BRE/COH GA LLC
 c/o Equity Office

2311 Cedar Springs Road, Suite 300
 Dallas, Texas 75201

Attention: Asset Manager
  

With copies of any notices to Landlord shall be sent to:
  

BRE/COH GA LLC
 c/o Lincoln Property Company

900 North Point Parkway, Suite 100
 Alpharetta, Georgia 30005

Attention: Property Manager
  

and
  

BRE/COH GA LLC
 c/o Equity Office

222 South Riverside Plaza
 Suite 2000

Chicago, Illinois 60606
 Attention: Managing Counsel
	  	 Prior to the Commencement Date:
  

Clearside Biomedical, Inc.
 1220 Old Alpharetta Road

Suite 300
 Alpharetta, Georgia 30005

 
 From and after the Commencement Date:

 
 Clearside Biomedical, Inc.

900 North Point Parkway
 Suite 250

Alpharetta, Georgia 30005


  

	 	1.13	“Business Day(s)” are Monday through Friday of each week, exclusive of New Year’s Day, Presidents Day, Memorial Day, Independence Day, Labor Day, Thanksgiving Day and Christmas Day
(“Holidays”). Landlord may designate additional Holidays that are commonly recognized by other office buildings in the area where the Building is located. “Building Service Hours” are 8:00
A.M. to 6:00 P.M. on Business Days and 8:00 A.M. to 1:00 P.M. on Saturdays. 


 

	 	1.14	“Landlord Work” means the work that Landlord is obligated to perform in the Premises pursuant to a separate agreement (the “Work Letter”) attached to this Lease as
Exhibit C. 

  

	 	1.15	“Property” means the Building and the parcel(s) of land on which it is located and, at Landlord’s discretion, the parking facilities and other improvements, if any, serving the Building and the
parcel(s) of land on which they are located. 

  

	 	1.16	“Letter of Credit” is as described in Section 5 of Exhibit F attached hereto. 


  
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 2. Lease Grant. 

Landlord hereby leases the Premises to Tenant and Tenant hereby leases the Premises from Landlord. Landlord further grants to Tenant the non-exclusive right
to use any portions of the Property that are designated by Landlord for the common use of tenants and others (the “Common Areas”). 
 3.
Adjustment of Commencement Date; Possession. 
 3.01 The Landlord Work shall be deemed to be “Substantially
Complete” on the later of (i) the date that all Landlord Work has been performed, other than any details of construction, mechanical adjustment or any other similar matter, the noncompletion of which does not materially interfere with
Tenant’s use of the Premises; and (ii) the date Landlord receives from the appropriate governmental authorities, with respect to the Landlord Work performed by Landlord or its contractors in the Premises, all approvals necessary for the
occupancy of the Premises (or would have received such approvals absent any Tenant Delays). If Landlord is delayed in the performance of the Landlord Work as a result of the acts or omissions of Tenant, the Tenant Related Parties (defined in
Section 13) or their respective contractors or vendors, including, without limitation, changes requested by Tenant to approved plans, Tenant’s failure to comply with any of its obligations under this Lease, or Tenant’s specification
of any materials or equipment with long lead times (each a “Tenant Delay”), the Landlord Work shall be deemed to be Substantially Complete on the date that Landlord could reasonably have been expected to Substantially Complete the
Landlord Work absent any Tenant Delay. Notwithstanding anything to the contrary in Section 1.06 above, Landlord’s failure to Substantially Complete the Landlord Work by the Target Commencement Date (described in Section 1.06) shall
not be a default by Landlord or otherwise render Landlord liable for damages. Promptly after the determination of the Commencement Date, Landlord and Tenant shall execute and deliver a commencement letter in the form attached as Exhibit D
(the “Commencement Letter”). Tenant’s failure to execute and return the Commencement Letter, or to provide written objection to the statements contained in the Commencement Letter, within 30 days after the date of the
Commencement Letter shall be deemed an approval by Tenant of the statements contained therein. Landlord shall use reasonable efforts to notify Tenant, orally or in writing, of any circumstances of which Landlord is aware that have caused or may
cause a Tenant Delay (including informing Tenant of long lead times related to availability of materials), so that Tenant may take whatever action is appropriate to minimize or prevent such Tenant Delay. 

3.02 Subject to Landlord’s obligation to perform Landlord Work, the Premises are accepted by Tenant in “as is” condition and
configuration without any representations or warranties by Landlord. By taking possession of the Premises, Tenant agrees that the Premises are in good order and satisfactory condition. Notwithstanding the foregoing, Landlord represents that to
Landlord’s knowledge, the mechanical (including HVAC), electrical, plumbing and fire/life safety systems serving the Premises are in good working order as of the date of this Lease. Notwithstanding the foregoing, Landlord shall be responsible
for latent defects in the Landlord Work of which Tenant notifies Landlord to the extent that the correction of such defects is covered under valid and enforceable warranties given Landlord by contractors or subcontractors performing the Landlord
Work. Landlord, at its option, may pursue such claims directly or assign any such warranties to Tenant for enforcement. Tenant’s acceptance of the Premises shall be subject to Landlord’s obligation to correct portions of the Landlord Work
as set forth on a construction punch list prepared by Landlord and Tenant in accordance with the terms hereof. Within 15 days after Substantial Completion of the Landlord Work, Landlord and Tenant shall together conduct an inspection of the Premises
and prepare a “punch list” setting 

  
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forth any portions of the Landlord Work that are not in conformity with the Landlord Work as required by the terms of this Lease. Notwithstanding the foregoing, at the request of Landlord, such
construction punch list shall be mutually prepared by Landlord and Tenant prior to the date on which Tenant first begins to move its furniture, equipment or other personal property into the Premises. Landlord, as part of the Landlord Work, shall use
good faith efforts to correct all such items within a reasonable time following the completion of the punch list. Landlord shall not be liable for a failure to deliver possession of the Premises or any other space due to the holdover or unlawful
possession of such space by another party, provided, however, Landlord shall use reasonable efforts to obtain possession of any such space. In such event, the Commencement Date for the Premises, or the commencement date for such other space, as
applicable, shall be postponed until the date Landlord delivers possession of such space to Tenant free from occupancy by any party. Except as otherwise provided in this Lease, Tenant shall not be permitted to take possession of or enter the
Premises prior to the Commencement Date without Landlord’s permission. If Tenant takes possession of or enters the Premises before the Commencement Date, Tenant shall be subject to the terms and conditions of this Lease; provided, however,
except for the cost of services requested by Tenant (e.g. after hours HVAC service), Tenant shall not be required to pay Rent for any entry or possession before the Commencement Date during which Tenant, with Landlord’s approval, has entered,
or is in possession of, the Premises for the sole purpose of performing improvements or installing furniture, equipment or other personal property. However, notwithstanding the foregoing but subject to the terms of this Section 3.02, Landlord
shall use its reasonable efforts to permit Tenant to enter the Premises after notice from Landlord, at Tenant’s sole risk, at least 14 days prior to the Commencement Date, solely for the purpose of installing equipment, furnishings and other
personalty provided that such installations do not interfere with the Landlord Work. The parties agree to cooperate reasonably to coordinate their respective access to and work within the Premises so as to minimize any delay to the performance of
the Landlord Work. Landlord may withdraw such permission to enter the Premises prior to the Commencement Date at any time that Landlord reasonably determines that such entry by Tenant is causing a dangerous situation for Landlord, Tenant or their
respective contractors or employees, or if Landlord reasonably determines that such entry by Tenant is hampering or otherwise preventing Landlord from proceeding with the completion of the Landlord Work at the earliest possible date, provided that
Landlord agrees to act reasonably in making any such determination in light of the mutual obligation of Landlord and Tenant to cooperate reasonably to coordinate their respective work as set forth above. 

3.03 If (i) Landlord has received all required permits for the performance of the Landlord Work within 30 days after the date of this
Lease, and (ii) the Commencement Date has not occurred on or before April 15, 2017 (the “Outside Completion Date”), Tenant shall be entitled to a rent abatement following the Base Rent Abatement Period of $1,155.45 for
every day in the period beginning on the Outside Completion Date and ending on the Commencement Date. Landlord and Tenant acknowledge and agree that: (a) the determination of the Commencement Date shall take into consideration the effect of any
Tenant Delays; and (b) the Outside Completion Date shall be postponed by the number of days the Commencement Date is delayed due to events of Force Majeure and the number of days Landlord is delayed in obtaining all required permits for the
performance of the Landlord Work beyond the initial 30 day period after the date of this Lease. 
 4. Rent. 

4.01 Tenant shall pay Landlord, without any setoff or deduction, unless expressly set forth in this Lease, all Base Rent and Additional Rent
due for the Term (collectively referred to 

  
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as “Rent”). “Additional Rent” means all sums (exclusive of Base Rent) that Tenant is required to pay Landlord under this Lease. Tenant shall pay and be liable
for all rental, sales and use taxes (but excluding income taxes), if any, imposed upon or measured by Rent. Base Rent and recurring monthly charges of Additional Rent shall be due and payable in advance on the first day of each calendar month
without notice or demand, provided that the installment of Base Rent for the seventh full calendar month of the Term shall be payable upon the execution of this Lease by Tenant. All other items of Rent shall be due and payable by Tenant on or before
30 days after billing by Landlord. Rent shall be made payable to the entity, and sent to the address, Landlord designates and shall be made by good and sufficient check payable in United States of America currency or by other means acceptable to
Landlord. If Tenant does not pay any Rent when due hereunder, Tenant shall pay Landlord an administration fee in the amount of $250.00, provided that Tenant shall be entitled to a grace period of up to 5 Business Days for the first 2 late payments
of Rent in a calendar year. In addition, past due Rent shall accrue interest at 10% per annum, and Tenant shall pay Landlord a reasonable fee for any checks returned by Tenant’s bank for any reason. Landlord’s acceptance of less than
the correct amount of Rent shall be considered a payment on account of the oldest obligation due from Tenant hereunder, then to any current Rent then due hereunder, notwithstanding any statement to the contrary contained on or accompanying any such
payment from Tenant. Rent for any partial month during the Term shall be prorated. No endorsement or statement on a check or letter accompanying payment shall be considered an accord and satisfaction. Tenant’s covenant to pay Rent is
independent of every other covenant in this Lease. 
 4.02 Tenant shall pay Tenant’s Pro Rata Share of Taxes and Expenses in accordance
with Exhibit B of this Lease. 
 5. Compliance with Laws; Use. 

The Premises shall be used for the Permitted Use and for no other use whatsoever. Tenant shall comply with all statutes, codes, ordinances, orders, rules and
regulations of any municipal or governmental entity whether in effect now or later, including the Americans with Disabilities Act (“Law(s)”), regarding the operation of Tenant’s business, the use, condition, configuration and
occupancy of the Premises and the Building systems located in or exclusively serving the Premises. During the Term, Landlord shall be responsible, at its cost (except to the extent properly included in Expenses), for correcting any violations of
Laws relating to or affecting the condition, use or occupancy of the Common Areas except for any obligations specifically imposed upon Tenant pursuant to this Lease. Notwithstanding the foregoing, Landlord shall have the right to contest any alleged
violation of any of the foregoing in good faith, or bring suit against any third party causing such violation of Laws, including, without limitation, the right to apply for and obtain a waiver or deferment of compliance, the right to assert any and
all defenses allowed by law and the right to appeal any decisions, judgments or rulings to the fullest extent permitted by Law. Landlord, after the exhaustion of any and all rights to appeal, contest or litigate, will make all repairs, additions,
alterations, improvements or adjustments necessary to comply with the terms of any final order or judgment. In addition, Tenant shall, at its sole cost and expense, promptly comply with any Laws that relate to the “Base Building” (defined
below), but only to the extent such obligations are triggered by Tenant’s use of the Premises, other than for general office use, or Alterations or improvements in the Premises performed or requested by Tenant. “Base Building”
shall include the structural portions of the Building, the public restrooms and the Building mechanical, electrical and plumbing systems and equipment located in the internal core of the Building on the floor or floors on which the Premises are
located. Tenant shall promptly provide Landlord with copies of any notices it receives regarding an alleged violation of Law. Tenant shall not exceed the standard density 

  
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limit for the Building. Tenant shall comply with the rules and regulations of the Building attached as Exhibit E and such other reasonable rules and regulations adopted by Landlord
from time to time, including rules and regulations for the performance of Alterations (defined in Section 9.03). The rules and regulations shall be generally applicable, and generally applied in the same manner, to all tenants of the Building.

 6. Security Deposit. 
 The Security Deposit, if any,
shall be delivered to Landlord upon the execution of this Lease by Tenant and held by Landlord without liability for interest (unless required by Law) as security for the performance of Tenant’s obligations. The Security Deposit is not an
advance payment of Rent or a measure of damages. Landlord may from time to time and without prejudice to any other remedy provided in this Lease or by Law, use all or a portion of the Security Deposit to the extent necessary to satisfy past due Rent
or to satisfy any other loss or damage resulting from Tenant’s breach under this Lease. If Landlord uses any portion of the Security Deposit, Tenant, within 5 days after demand, shall restore the Security Deposit to its original amount.
Landlord shall return any unapplied portion of the Security Deposit to Tenant within 45 days after the later to occur of: (a) determination of the final Rent due from Tenant; or (b) the later to occur of the Termination Date or the date
Tenant surrenders the Premises to Landlord in compliance with Section 25. Landlord may assign the Security Deposit to a successor or transferee and, following the assignment, Landlord shall have no further liability for the return of the
Security Deposit. Landlord shall not be required to keep the Security Deposit separate from its other accounts. 
 7. Building Services. 

7.01 Landlord shall furnish Tenant with the following services: (a) water for use in the Base Building lavatories; (b) customary
heat and air conditioning in season during all Building Service Hours plus air conditioning such that the temperature does not exceed 76 degrees Fahrenheit until 6:30 p.m. Monday through Thursday from June through August on Business Days, although
(i) Tenant shall have the right to receive HVAC service during hours other than set forth herein by paying Landlord’s then standard charge for additional HVAC service and providing such prior notice as is reasonably specified by Landlord,
and (ii) if Tenant is permitted to connect any supplemental HVAC units to the Building’s condenser water loop or chilled water line, such permission shall be conditioned upon Landlord having adequate excess capacity from time to time and
such connection and use shall be subject to Landlord’s reasonable approval and reasonable restrictions imposed by Landlord, and Landlord shall have the right to charge Tenant a connection fee and/or a monthly usage fee, as reasonably determined
by Landlord; (c) standard janitorial service on Business Days; (d) elevator service; (e) electricity in accordance with the terms and conditions in Section 7.02; (f) access to the Building for Tenant and its employees 24
hours per day/7 days per week, subject to the terms of this Lease and such protective services or monitoring systems, if any, as Landlord may reasonably impose, including, without limitation, sign-in procedures and/or presentation of identification
cards; (g) snow and ice removal; (h) landscaping services; and (i) such other services as Landlord reasonably determines are necessary or appropriate for the Property. If Landlord, at Tenant’s request, provides any services which
are not Landlord’s express obligation under this Lease, including, without limitation, any repairs which are Tenant’s responsibility pursuant to Section 9 below, Tenant shall pay Landlord, or such other party designated by Landlord,
the cost of providing such service plus a reasonable administrative charge. 

  
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 7.02 Electricity used by Tenant in the Premises shall, at Landlord’s option, be paid for by
Tenant either: (a) through inclusion in Expenses (except as provided for excess usage); (b) by a separate charge payable by Tenant to Landlord; or (c) by separate charge billed by the applicable utility company and payable directly by
Tenant. Without the consent of Landlord, Tenant’s use of electrical service shall not exceed the Building standard usage, per square foot, as reasonably determined by Landlord, based upon the Building standard electrical design load. Landlord
shall have the right to measure electrical usage by commonly accepted methods, including the installation of measuring devices such as submeters and check meters. If it is determined that Tenant is using electricity in such quantities or during such
periods as to cause the total cost of Tenant’s electrical usage, on a monthly, per-rentable-square-foot basis, to materially exceed that which Landlord reasonably deems to be standard for the Building, Tenant shall pay Landlord Additional Rent
for the cost of such excess electrical usage and, if applicable, for the cost of purchasing and installing the measuring device(s). For purposes hereof, the Building “electrical standard” is 5 watts per usable square foot of connected load
to the Premises, exclusive of base Building HVAC. 
 7.03 Landlord’s failure to furnish, or any interruption, diminishment or
termination of services due to the application of Laws, the failure of any equipment, the performance of maintenance, repairs, improvements or alterations, utility interruptions or the occurrence of an event of Force Majeure (defined in
Section 26.03) (collectively a “Service Failure”) shall not render Landlord liable to Tenant, constitute a constructive eviction of Tenant, give rise to an abatement of Rent, nor relieve Tenant from the obligation to fulfill
any covenant or agreement. However, if the Premises, or a material or critical business portion of the Premises, are made untenantable for a period in excess of 3 consecutive Business Days as a result of a Service Failure that is reasonably within
the control of Landlord to correct, then Tenant, as its sole remedy, shall be entitled to receive an abatement of Rent payable hereunder during the period beginning on the 4th consecutive Business
Day of the Service Failure and ending on the day the service has been restored. If the entire Premises have not been rendered untenantable by the Service Failure, the amount of abatement shall be equitably prorated. 

8. Leasehold Improvements. 
 All improvements in and to
the Premises, including any Alterations (defined in Section 9.03) (collectively, “Leasehold Improvements”) shall remain upon the Premises at the end of the Term without compensation to Tenant, provided that Tenant, at its
expense, shall remove any Cable (defined in Section 9.01 below). In addition, Landlord, by written notice to Tenant at least 30 days prior to the Termination Date, may require Tenant, at Tenant’s expense, to remove any Landlord Work or
Alterations that, in Landlord’s reasonable judgment, are of a nature that would require removal and repair costs that are materially in excess of the removal and repair costs associated with standard office improvements (the Cable and such
other items collectively are referred to as “Required Removables”). Required Removables shall include, without limitation, internal stairways, raised floors, personal baths and showers, vaults, rolling file systems and structural
alterations and modifications. The Required Removables shall be removed by Tenant before the Termination Date. Tenant shall repair damage caused by the installation or removal of Required Removables. If Tenant fails to perform its obligations in a
timely manner, Landlord may perform such work at Tenant’s expense. Notwithstanding the foregoing to the contrary, Tenant, at the time it requests approval for a proposed Alteration, including any Landlord Work, as such term may be defined in
the Work Letter attached as Exhibit C, may request in writing that Landlord advise Tenant whether the Alteration, including any Landlord Work, or any portion thereof, is a Required Removable. Within 10 days after receipt of Tenant’s
request, Landlord shall advise Tenant in writing as to which portions of the alteration or other improvements are 

  
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Required Removables. If Landlord fails to advise Tenant in writing as to whether the Alteration or any portion of the Alteration will be designated as a Required Removable (the “Required
Removable Advice”) within the period set forth above, Tenant shall have the right to provide Landlord with a second request for the Required Removable Advice. Tenant’s second request for the Required Removable Advice must specifically
state that Landlord’s failure to respond within a period of 10 days shall be deemed to mean that the Alteration, or such portion of the Alteration specifically requested by Tenant, will not be designated as a Required Removable. If
Landlord’s failure to respond continues for 10 days after its receipt of the second request for the Required Removable Advice, then Landlord shall be deemed to have agreed that the Alteration, or such portion of the Alteration for which Tenant
has requested the Required Removable Advice, will not be designated as a Required Removable. 
 9. Repairs and Alterations. 

9.01 Tenant shall periodically inspect the Premises to identify any conditions that are dangerous or in need of maintenance or repair. Tenant
shall promptly provide Landlord with notice of any such conditions. Tenant, at its sole cost and expense, shall perform all maintenance and repairs to the Premises that are not Landlord’s express responsibility under this Lease, and keep the
Premises in good condition and repair, reasonable wear and tear and damage by Casualty (subject to the terms of Section 16) and condemnation (subject to the terms of Section 17) excepted. Tenant’s repair and maintenance obligations
include, without limitation, repairs to: (a) floor covering; (b) interior partitions; (c) doors; (d) the interior side of demising walls; (e) Alterations (described in Section 9.03); (f) supplemental air
conditioning units, kitchens, including hot water heaters, plumbing, and similar facilities exclusively serving Tenant, whether such items are installed by Tenant or are currently existing in the Premises but not including any components that are
Landlord’s express responsibility; and (g) electronic, fiber, phone and data cabling and related equipment that is installed by or for the exclusive benefit of Tenant (collectively, “Cable”). All repairs and other work
performed by Tenant or its contractors, including that involving Cable, shall be subject to the terms of Section 9.03 below. If Tenant fails to make any repairs to the Premises for more than 15 days after notice from Landlord (although notice
shall not be required in an emergency), Landlord may make the repairs, and, within 30 days after demand, Tenant shall pay the reasonable cost of the repairs, together with an administrative charge in an amount equal to 10% of the cost of the
repairs. 
 9.02 Landlord shall keep and maintain in good repair and working order and perform maintenance upon the: (a) structural
elements of the Building; (b) mechanical (including HVAC), electrical, plumbing and fire/life safety systems serving the Building and the Common Areas in general; (c) Common Areas; (d) roof of the Building and roof membrane;
(e) exterior windows of the Building and exterior demising walls; and (f) elevators serving the Building. Landlord shall promptly make repairs for which Landlord is responsible. 

9.03 Tenant shall not make alterations, repairs, additions or improvements or install any Cable (collectively referred to as
“Alterations”) without first obtaining the written consent of Landlord in each instance, which consent shall not be unreasonably withheld, conditioned or delayed. However, Landlord’s consent shall not be required for any
Alteration that satisfies all of the following criteria (a “Cosmetic Alteration”): (a) is of a cosmetic nature such as painting, wallpapering, hanging pictures and installing carpeting; (b) is not visible from the exterior
of the Premises or Building; (c) will not affect the Base Building (defined in Section 5); and (d) does not require work to be performed inside the walls or above the ceiling of the Premises. Cosmetic Alterations shall be subject to
all the other provisions of this Section 9.03. Prior to starting work, Tenant shall furnish Landlord with plans and specifications (which shall be in CAD 

  
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format if requested by Landlord), although such plans and specifications need be supplied to Landlord only if they are necessary for the issuance of required permits or if reasonably deemed
necessary by Landlord due to the nature of the work to be performed; names of contractors reasonably acceptable to Landlord (provided that Landlord may designate specific contractors with respect to Base Building and vertical Cable, as may be
described more fully below); required permits and approvals; evidence of contractor’s and subcontractor’s insurance in amounts reasonably required by Landlord and naming Landlord and the managing agent for the Building (or any
successor(s)) as additional insureds; and any security for performance in amounts reasonably required by Landlord. Landlord may designate specific contractors with respect to oversight, installation, repair, connection to, and removal of vertical
Cable. All Cable shall be clearly marked with adhesive plastic labels (or plastic tags attached to such Cable with wire) to show Tenant’s name, suite number, and the purpose of such Cable (i) every 6 feet outside the Premises (specifically
including, but not limited to, the electrical room risers and any Common Areas), and (ii) at the termination point(s) of such Cable. Changes to the plans and specifications must also be submitted to Landlord for its approval. Alterations shall
be constructed in a good and workmanlike manner using materials of a quality reasonably approved by Landlord, and Tenant shall ensure that no Alteration impairs any Building system or Landlord’s ability to perform its obligations hereunder.
Tenant shall reimburse Landlord for any reasonable sums paid by Landlord for third party examination of Tenant’s plans for non-Cosmetic Alterations. In addition, Tenant shall pay Landlord a fee for Landlord’s oversight and coordination of
any non-Cosmetic Alterations equal to 7% of the cost of the non-Cosmetic Alterations. Upon completion, Tenant shall furnish “as-built” plans (in CAD format, if requested by Landlord) for non-Cosmetic Alterations, completion affidavits and
full and final waivers of lien. Landlord’s approval of an Alteration shall not be deemed a representation by Landlord that the Alteration complies with Law. 

10. Entry by Landlord. 
 Landlord may enter the Premises
to inspect, show or clean the Premises or to perform or facilitate the performance of repairs, alterations or additions to the Premises or any portion of the Building. Except in emergencies or to provide Building services, Landlord shall provide
Tenant with reasonable prior verbal notice of entry and shall use reasonable efforts to minimize any interference with Tenant’s use of the Premises. Notwithstanding the foregoing, except in emergencies or to provide Building services, Landlord
shall provide Tenant with at least 12 hours’ prior notice of entry into the Premises, which may be given orally to the entity occupying the Premises. If reasonably necessary, Landlord may temporarily close all or a portion of the Premises to
perform repairs, alterations and additions. However, except in emergencies, Landlord will not close the Premises if the work can reasonably be completed on weekends and after Building Service Hours. Entry by Landlord shall not constitute a
constructive eviction or entitle Tenant to an abatement or reduction of Rent. 
 11. Assignment and Subletting. 

11.01 Except in connection with a Business Transfer (defined in Section 11.04), Tenant shall not assign, sublease, transfer or encumber
any interest in this Lease or allow any third party to use any portion of the Premises (collectively or individually, a “Transfer”) without the prior written consent of Landlord, which consent shall not be unreasonably withheld,
conditioned or delayed if Landlord does not exercise its recapture rights under Section 11.02. Without limitation, it is agreed that Landlord’s consent shall not be considered unreasonably withheld if the proposed transferee intends to use
the Lab Space in the Premises in a different way, for different purposes or with different substances or materials than the originally named Tenant 

  
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under this Lease. In addition it is agreed that Landlord’s consent shall not be considered unreasonably withheld if the proposed transferee is a governmental entity or an occupant of the
Building or an occupant of the building located at 800 North Point Parkway, Alpharetta, Georgia (the “800 North Point Building”) or if the proposed transferee, whether or not an occupant of the Building or an occupant of the 800
North Point Building, is in discussions with Landlord regarding the leasing of space within the Building or within the 800 North Point Building. Notwithstanding the above, Landlord will not withhold its consent solely because the proposed subtenant
or assignee is an occupant of the Building or an occupant of the 800 North Point Building if Landlord does not have space available for lease in the Building or the 800 North Point Building that is comparable to the space Tenant desires to sublet or
assign. Landlord shall be deemed to have comparable space if it has, or will have, space available on any floor of the Building or on any floor of the 800 North Point Building that is approximately the same size as the space Tenant desires to sublet
or assign within 6 months of the proposed commencement of the proposed sublease or assignment. If the entity(ies) which directly or indirectly controls 50% or more of the voting shares/rights of Tenant (other than through the ownership of voting
securities listed on a recognized securities exchange) changes at any time, such change of ownership or control shall constitute a Transfer. Any Transfer in violation of this Section shall, at Landlord’s option, be deemed a Default by Tenant as
described in Section 18, and shall be voidable by Landlord. In no event shall any Transfer, including a Business Transfer, release or relieve Tenant from any obligation under this Lease, and Tenant shall remain primarily liable for the
performance of the tenant’s obligations under this Lease, as amended from time to time. 
 11.02 Tenant shall provide Landlord with
financial statements for the proposed transferee (or, in the case of a change of ownership or control, for the proposed new controlling entity(ies)), which may be subject to reasonable confidentiality restrictions, a fully executed copy of the
proposed assignment, sublease or other Transfer documentation and such other information as Landlord may reasonably request. Within 15 Business Days after receipt of the required information and documentation, Landlord shall either: (a) consent
to the Transfer by execution of a consent agreement in a form reasonably designated by Landlord; (b) reasonably refuse to consent to the Transfer in writing; or (c) in the event of an assignment of this Lease or subletting of more than 20%
of the Rentable Square Footage of the Premises for more than 50% of the remaining Term (excluding unexercised options), recapture the portion of the Premises that Tenant is proposing to Transfer. If Landlord exercises its right to recapture, this
Lease shall automatically be amended (or terminated if the entire Premises is being assigned or sublet) to delete the applicable portion of the Premises effective on the proposed effective date of the Transfer, although Landlord may require Tenant
to execute a reasonable amendment or other document reflecting such reduction or termination. Tenant shall pay Landlord a review fee of $1,500.00 for Landlord’s review of any requested Transfer. 

11.03 Tenant shall pay Landlord 50% of all rent and other consideration which Tenant receives as a result of a Transfer that is in excess of
the Rent payable to Landlord for the portion of the Premises and Term covered by the Transfer. Tenant shall pay Landlord for Landlord’s share of the excess within 30 days after Tenant’s receipt of the excess. In determining excess rent due
Landlord, Tenant may deduct from the excess, on a straight line basis, all reasonable and customary expenses directly incurred by Tenant attributable to the Transfer, including brokerage fees, legal fees, construction costs, and Landlord’s
review fee. If Tenant is in Default, Landlord may require that all sublease payments be made directly to Landlord, in which case Tenant shall receive a credit against Rent in the amount of Tenant’s share of payments received by Landlord.
However, by accepting any such payments directly from the subtenant, whether as a result of the foregoing or otherwise, Landlord does not waive any claims against the Tenant hereunder or release Tenant from any obligations under this Lease, nor
recognize the subtenant as the tenant under the Lease. 

  
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 11.04 Tenant may (i) assign this Lease to a successor to Tenant by merger, consolidation,
reorganization or the purchase of all or substantially all of Tenant’s assets, or (ii) assign this Lease or sublet all or a portion of the Premises to an Affiliate (defined below), or (iii) sell a controlling interest in Tenant’s
stock, partnership or membership interests, without the consent of Landlord, provided that all of the following conditions are satisfied (a “Business Transfer”): (a) Tenant must not be in Default; (b) Tenant must give
Landlord written notice at least 15 Business Days before such Transfer; (c) if such Transfer will result from a merger, consolidation or reorganization of Tenant with another entity, or the purchase of all or substantially all of Tenant’s
assets by another entity, then the Credit Requirement (defined below) must be satisfied, and (d) if such Transfer involves the sale of a controlling interest in Tenant’s stock, partnership or membership interests, the Credit Requirement
must be satisfied. Tenant’s notice to Landlord shall include information and documentation evidencing the Business Transfer and showing that each of the above conditions has been satisfied. If requested by Landlord, Tenant’s successor
shall sign and deliver to Landlord a commercially reasonable form of assumption agreement. “Affiliate” shall mean an entity controlled by, controlling or under common control with Tenant. The “Credit Requirement”
shall be deemed satisfied if, as of the date immediately succeeding the date of the Business Transfer, the financial strength of either (a) Tenant, in the event of a sale of a controlling interest in Tenant’s stock, partnership or
membership interests, or (b) the entity with which Tenant is to merge, consolidate or reorganize in the event of a merger, consolidation or reorganization, or (c) the entity which is purchasing all or substantially all of Tenant’s
assets in the event of a sale of all or substantially all of Tenant’s assets, is not less than that of Tenant as of the date immediately preceding the Transfer as determined (x) based on credit ratings of such entity and Tenant by both
Moody’s and Standard & Poor’s (or by either such agency alone, if applicable ratings by the other agency do not exist), or (y) if such credit ratings do not exist, then in accordance with Moody’s KMV RiskCalc (i.e., the
on-line software tool offered by Moody’s for analyzing credit risk) based on CFO-certified financial statements for such entity and Tenant covering their last two fiscal years ending before the Transfer. 

11.05 Notwithstanding anything to the contrary contained in this Section 11, neither Tenant nor any other person having a right to
possess, use, or occupy (for convenience, collectively referred to in this subsection as “Use”) the Premises shall enter into any lease, sublease, license, concession or other agreement for Use of all or any portion of the Premises
which provides for rental or other payment for such Use based, in whole or in part, on the net income or profits derived by any person that leases, possesses, uses, or occupies all or any portion of the Premises (other than an amount based on a
fixed percentage or percentages of receipts or sales), and any such purported lease, sublease, license, concession or other agreement shall be absolutely void and ineffective as a transfer of any right or interest in the Use of all or any part of
the Premises. 
 12. Liens. 
 Tenant shall not permit
mechanics’ or other liens to be placed upon the Property, Premises or Tenant’s leasehold interest in connection with any work or service done or purportedly done by or for the benefit of Tenant or its subtenants or transferees. Tenant
shall give Landlord notice at least 10 days prior to the commencement of any Alterations in the Premises to afford Landlord the opportunity, where applicable, to post and record notices of non-responsibility. Tenant, within 20 days of notice from
Landlord, shall fully discharge any lien by settlement, by bonding 

  
 12 








 
or by insuring over the lien in the manner prescribed by the applicable lien Law and, if Tenant fails to do so, Tenant shall be deemed in Default under this Lease and, in addition to any other
remedies available to Landlord as a result of such Default by Tenant, Landlord, at its option, may bond, insure over or otherwise discharge the lien. Tenant shall reimburse Landlord for any amount paid by Landlord, including, without
limitation, reasonable attorneys’ fees. Landlord shall have the right to require Tenant to post a performance or payment bond in connection with any work or service done or purportedly done by or for the benefit of Tenant. Tenant acknowledges
and agrees that all such work or service is being performed for the sole benefit of Tenant and not for the benefit of Landlord. 
 13. Indemnity and
Waiver of Claims. 
 Except to the extent caused by the negligence or willful misconduct of Landlord or any Landlord Related Parties (defined below),
Tenant shall indemnify, defend and hold Landlord and Landlord Related Parties harmless against and from all liabilities, obligations, damages, penalties, claims, actions, costs, charges and expenses, including, without limitation, reasonable
attorneys’ fees and other professional fees (if and to the extent permitted by Law) (collectively referred to as “Losses”), which may be imposed upon, incurred by or asserted against Landlord or any of the Landlord Related
Parties by any third party and arising out of or in connection with any damage or injury occurring in the Premises or any acts or omissions (including violations of Law) of Tenant, its trustees, managers, members, principals, beneficiaries,
partners, officers, directors, employees and agents (the “Tenant Related Parties”) or any of Tenant’s transferees, contractors or licensees. Tenant hereby waives all claims against and releases Landlord and its trustees,
managers, members, principals, beneficiaries, partners, officers, directors, employees, Mortgagees (defined in Section 23) and agents (the “Landlord Related Parties”) from all claims for any injury to or death of persons,
damage to property or business loss in any manner related to (a) Force Majeure, (b) acts of third parties, (c) the bursting or leaking of any tank, water closet, drain or other pipe, (d) the inadequacy or failure of any security
or protective services, personnel or equipment, or (e) any matter not within the reasonable control of Landlord. Notwithstanding the foregoing, except as provided in Section 15 to the contrary, Tenant shall not be required to waive any
claims against Landlord (except, to the extent permitted by Law, for loss or damage to Tenant’s business) where such loss or damage is due to the negligence or willful misconduct of Landlord or any Landlord Related Parties. 

14. Tenant’s Insurance. Tenant shall maintain the following coverages in the following amounts: 

14.01 Commercial General Liability Insurance covering claims of bodily injury, personal injury and property damage arising out of
Tenant’s operations and contractual liabilities, including coverage formerly known as broad form, on an occurrence basis, with minimum primary limits of $1,000,000 each occurrence and $2,000,000 annual aggregate (and not more than $25,000
self-insured retention) and a minimum excess/umbrella limit of $2,000,000. 
 14.02 Property insurance covering (i) all office
furniture, business and trade fixtures, office equipment, free-standing cabinet work, movable partitions, merchandise and all other items of Tenant’s property in the Premises installed by, for, or at the expense of Tenant
(“Tenant’s Property”), and (ii) any Leasehold Improvements installed by or for the benefit of Tenant, whether pursuant to this Lease or pursuant to any prior lease or other agreement to which Tenant was a party
(“Tenant-Insured Improvements”). Such insurance shall be written on a special cause of loss form for physical loss or damage, for the full replacement cost value (subject to reasonable deductible amounts) without deduction for
depreciation of the covered 

  
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items and in amounts that meet any co-insurance clauses of the policies of insurance, and shall include coverage for damage or other loss caused by fire or other peril, including vandalism and
malicious mischief, theft, water damage of any type, including sprinkler leakage, bursting or stoppage of pipes, and explosion. 
 14.03
Worker’s Compensation and Employer’s Liability or other similar insurance to the extent required by Law. 
 14.04 Form of
Policies. The minimum limits of insurance required to be carried by Tenant shall not limit Tenant’s liability. Such insurance shall (i) be issued by an insurance company that has an A.M. Best rating of not less than A-VIII;
(ii) be in form and content reasonably acceptable to Landlord; and (iii) provide that it shall not be canceled without 30 days’ prior notice to Landlord, except that 10 days’ prior notice may be given in the case of nonpayment of
premiums. Tenant’s Commercial General Liability Insurance shall (a) name Landlord, Landlord’s managing agent, and any other party designated by Landlord (“Additional Insured Parties”) as additional insureds; and
(b) be primary insurance as to all claims thereunder and provide that any insurance carried by Landlord is excess and non-contributing with Tenant’s insurance. Landlord shall be designated as a loss payee with respect to Tenant’s
Property insurance on any Tenant-Insured Improvements. Tenant shall deliver to Landlord, on or before the Commencement Date and at least 15 days before the expiration dates thereof, certificates from Tenant’s insurance company on the forms
currently designated “ACORD 28” (Evidence of Commercial Property Insurance) and “ACORD 25-S” (Certificate of Liability Insurance) or the equivalent. Attached to the ACORD 25-S (or equivalent) there shall be an
endorsement naming the Additional Insured Parties as additional insureds which shall be binding on Tenant’s insurance company. Upon Landlord’s request, Tenant shall deliver to Landlord, in lieu of such certificates, copies of the policies
of insurance required to be carried under Section 14.01 showing that the Additional Insured Parties are named as additional insureds. 

14.05 Tenant shall maintain such increased amounts of the insurance required to be carried by Tenant under this Section 14, and such
other types and amounts of insurance covering the Premises and Tenant’s operations therein, as may be reasonably requested by Landlord, but not in excess of the amounts and types of insurance then being required by landlords of buildings
comparable to and in the vicinity of the Building. 
 15. Subrogation. 

Subject to Section 16, each party waives, and shall cause its insurance carrier to waive, any right of recovery against the other for any loss of or
damage to property which loss or damage is (or, if the insurance required hereunder had been carried, would have been) covered by insurance. For purposes of this Section 15, any deductible with respect to a party’s insurance shall be
deemed covered by, and recoverable by such party under, valid and collectable policies of insurance. 
 16. Casualty Damage. 

16.01 If all or any portion of the Premises becomes untenantable or inaccessible by fire or other casualty to the Premises or the Common Areas
(collectively a “Casualty”), Landlord, with reasonable promptness, shall cause a general contractor selected by Landlord to provide Landlord with a written estimate of the amount of time required, using standard working methods, to
substantially complete the repair and restoration of the Premises and any Common 

  
 14 








 
Areas necessary to provide access to the Premises (“Completion Estimate”). Landlord shall promptly forward a copy of the Completion Estimate to Tenant. If the Completion Estimate
indicates that the Premises or any Common Areas necessary to provide access to the Premises cannot be made tenantable within 210 days from the date the repair is started, then either party shall have the right to terminate this Lease upon written
notice to the other within 10 days after Tenant’s receipt of the Completion Estimate. Tenant, however, shall not have the right to terminate this Lease if the Casualty was caused by the negligence or intentional misconduct of Tenant or any
Tenant Related Parties. In addition, Landlord, by notice to Tenant within 90 days after the date of the Casualty, shall have the right to terminate this Lease if: (1) the Premises have been materially damaged and there is less than 1 year of
the Term remaining on the date of the Casualty; (2) any Mortgagee requires that the insurance proceeds be applied to the payment of the mortgage debt; or (3) a material uninsured loss to the Building or Premises occurs. Tenant shall have
the right to terminate this Lease if: (a) a substantial portion of the Premises has been damaged by Casualty and such damage cannot reasonably be repaired within 60 days after Tenant’s receipt of the Completion Estimate;
(b) there is less than 1 year of the Term remaining on the date of the Casualty; (c) the Casualty was not caused by the negligence or willful misconduct of Tenant or its agents, employees or contractors; and (d) Tenant provides
Landlord with written notice of its intent to terminate within 30 days after the date of Tenant’s receipt of the Completion Estimate. 

16.02 If this Lease is not terminated, Landlord shall promptly and diligently, subject to reasonable delays for insurance adjustment or other
matters beyond Landlord’s reasonable control, restore the Premises and Common Areas. Such restoration shall be to substantially the same condition that existed prior to the Casualty, except for modifications required by Law or any other
modifications to the Common Areas deemed desirable by Landlord. Notwithstanding Section 15 above, upon notice from Landlord, Tenant shall assign or endorse over to Landlord (or to any party designated by Landlord) all property insurance
proceeds payable to Tenant under Tenant’s insurance with respect to any Leasehold Improvements performed by or for the benefit of Tenant; provided if the estimated cost to repair such Leasehold Improvements exceeds the amount of insurance
proceeds received by Landlord from Tenant’s insurance carrier, the excess cost of such repairs shall be paid by Tenant to Landlord prior to Landlord’s commencement of repairs. Within 15 days of demand, Tenant shall also pay Landlord for
any additional excess costs that are determined during the performance of the repairs to such Leasehold Improvements. However, notwithstanding the foregoing, if Tenant has maintained the insurance required to be maintained by Tenant pursuant to the
terms of Section 14 of this Lease throughout the Term, and if the proceeds from the insurance required to be maintained by Tenant with respect to the Leasehold Improvements have been paid to Landlord prior to Landlord commencing repair of the
Leasehold Improvements, then Landlord agrees Tenant shall not be required to pay any deficiency between the estimated or actual Leasehold Improvement repair costs and the insurance proceeds received by Landlord from Tenant’s insurance until
after substantial completion of the repairs to the Leasehold Improvements, and such sums shall be payable by Tenant within 15 days after demand of Landlord. In no event shall Landlord be required to spend more for the restoration of the Premises and
Common Areas than the proceeds received by Landlord, whether insurance proceeds or proceeds from Tenant. Landlord shall not be liable for any inconvenience to Tenant, or injury to Tenant’s business resulting in any way from the Casualty or the
repair thereof. Provided that Tenant is not in Default, during any period of time that all or a material portion of the Premises is rendered untenantable as a result of a Casualty, the Rent shall abate for the portion of the Premises that is
untenantable and not used by Tenant. 

  
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 17. Condemnation. 

Either party may terminate this Lease if any material part of the Premises is taken or condemned for any public or quasi-public use under Law, by eminent
domain or private purchase in lieu thereof (a “Taking”). Landlord shall also have the right to terminate this Lease if there is a Taking of any portion of the Building or Property which would have a material adverse effect on
Landlord’s ability to profitably operate the remainder of the Building. Tenant may also terminate this Lease if there is a Taking of a material part of the Building such that Tenant is prevented from accessing the Premises or otherwise
utilizing the Premises for the purposes described herein. The terminating party shall provide written notice of termination to the other party within 45 days after it first receives notice of the Taking. The termination shall be effective as of the
effective date of any order granting possession to, or vesting legal title in, the condemning authority. If this Lease is not terminated, Base Rent and Tenant’s Pro Rata Share shall be appropriately adjusted to account for any reduction in the
square footage of the Building or Premises. All compensation awarded for a Taking shall be the property of Landlord. The right to receive compensation or proceeds are expressly waived by Tenant, provided, however, Tenant may file a separate claim
for Tenant’s Property and Tenant’s reasonable relocation expenses, provided the filing of the claim does not diminish the amount of Landlord’s award. If only a part of the Premises is subject to a Taking and this Lease is not
terminated, Landlord, with reasonable diligence, will restore the remaining portion of the Premises as nearly as practicable to the condition immediately prior to the Taking. 

18. Events of Default. 
 In addition to any other default
specifically described in this Lease, each of the following occurrences shall be a “Default”: (a) Tenant’s failure to pay any portion of Rent when due, if the failure continues for 3 Business Days after written notice to
Tenant (“Monetary Default”); (b) Tenant’s failure (other than a Monetary Default) to comply with any term, provision, condition or covenant of this Lease, if the failure is not cured within 10 days after written notice to
Tenant provided, however, if Tenant’s failure to comply cannot reasonably be cured within 10 days, Tenant shall be allowed additional time (not to exceed 90 days) as is reasonably necessary to cure the failure so long as Tenant begins the cure
within 10 days and diligently pursues the cure to completion; (c) Tenant permits a Transfer without Landlord’s required approval or otherwise in violation of Section 11 of this Lease; (d) Tenant or any Guarantor becomes
insolvent, makes a transfer in fraud of creditors, makes an assignment for the benefit of creditors, admits in writing its inability to pay its debts when due or forfeits or loses its right to conduct business; (e) the leasehold estate is taken
by process or operation of Law; (f) in the case of any ground floor or retail Tenant, Tenant does not take possession of or abandons or vacates all or any portion of the Premises for a period of 30 days or longer; or (g) Tenant is in
default beyond any notice and cure period under any other lease or agreement with Landlord at the Building or Property. If Landlord provides Tenant with notice of Tenant’s failure to comply with any specific provision of this Lease on 3
separate occasions during any 12 month period, Tenant’s subsequent violation of such provision shall, at Landlord’s option, be an incurable Default by Tenant. All notices sent under this Section shall be in satisfaction of, and not in
addition to, notice required by Law. 
 19. Remedies. 

19.01 Upon Default, Landlord shall have the right to pursue any one or more of the following remedies: 

(a) Terminate this Lease, in which case Tenant shall immediately surrender the Premises to Landlord. If Tenant fails to surrender the
Premises, Landlord, in compliance 

  
 16 








 
with Law, may enter upon and take possession of the Premises and remove Tenant, Tenant’s Property and any party occupying the Premises. Tenant shall pay Landlord, on demand, all past due
Rent and other losses and damages Landlord suffers as a result of Tenant’s Default, including, without limitation, all Costs of Reletting (defined below) and any deficiency that may arise from reletting or the failure to relet the Premises.
“Costs of Reletting” shall include all reasonable costs and expenses incurred by Landlord in reletting or attempting to relet the Premises, including, without limitation, legal fees, brokerage commissions, the cost of alterations
and the value of other concessions or allowances granted to a new tenant. Landlord agrees to use reasonable efforts to mitigate damages, provided that those efforts shall not require Landlord to relet the Premises in preference to any other space in
the Building or to relet the Premises to any party that Landlord could reasonably reject as a transferee pursuant to Section 11. 
 (b)
Terminate Tenant’s right to possession of the Premises and, in compliance with Law, remove Tenant, Tenant’s Property and any parties occupying the Premises. Landlord may (but shall not be obligated to) relet all or any part of the
Premises, without notice to Tenant, for such period of time and on such terms and conditions (which may include concessions, free rent and work allowances) as Landlord in its absolute discretion shall determine. Landlord may collect and receive all
rents and other income from the reletting. Tenant shall pay Landlord on demand all past due Rent, all Costs of Reletting and any deficiency arising from the reletting or failure to relet the Premises. The re-entry or taking of possession of the
Premises shall not be construed as an election by Landlord to terminate this Lease. Landlord agrees to use reasonable efforts to mitigate damages, provided that those efforts shall not require Landlord to relet the Premises in preference to any
other space in the Building or to relet the Premises to any party that Landlord could reasonably reject as a transferee pursuant to Section 11. 

19.02 In lieu of calculating damages under Section 19.01, Landlord may elect to receive as damages the sum of (a) all Rent accrued
through the date of termination of this Lease or Tenant’s right to possession, and (b) an amount equal to the total Rent that Tenant would have been required to pay for the remainder of the Term discounted to present value at the Prime
Rate (defined below) then in effect, minus the then present fair rental value of the Premises for the remainder of the Term, similarly discounted, after deducting all anticipated Costs of Reletting. “Prime Rate” shall be the per
annum interest rate publicly announced as its prime or base rate by a federally insured bank selected by Landlord in the state in which the Building is located. Such payment shall not constitute a penalty or forfeiture but shall constitute
liquidated damages for Tenant’s failure to comply with the terms of this Lease (Landlord’s actual damages in such event are impossible to ascertain and the amount set forth above is a reasonable estimate thereof). 

19.03 If Tenant is in Default of any of its non-monetary obligations under this Lease, Landlord shall have the right to perform such
obligations. Tenant shall reimburse Landlord for the cost of such performance upon demand together with an administrative charge equal to 10% of the cost of the work performed by Landlord. The repossession or re-entering of all or any part of the
Premises shall not relieve Tenant of its liabilities and obligations under this Lease. No right or remedy of Landlord shall be exclusive of any other right or remedy. Each right and remedy shall be cumulative and in addition to any other right and
remedy now or subsequently available to Landlord at Law or in equity. 

  
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 20. Limitation of Liability. 

NOTWITHSTANDING ANYTHING TO THE CONTRARY CONTAINED IN THIS LEASE, THE LIABILITY OF LANDLORD (AND OF ANY SUCCESSOR LANDLORD) SHALL BE LIMITED TO THE INTEREST
OF LANDLORD IN THE PROPERTY. TENANT SHALL LOOK SOLELY TO LANDLORD’S INTEREST IN THE PROPERTY FOR THE RECOVERY OF ANY JUDGMENT OR AWARD AGAINST LANDLORD OR ANY LANDLORD RELATED PARTY. NEITHER LANDLORD NOR ANY LANDLORD RELATED PARTY SHALL BE
PERSONALLY LIABLE FOR ANY JUDGMENT OR DEFICIENCY, AND IN NO EVENT SHALL LANDLORD OR ANY LANDLORD RELATED PARTY BE LIABLE TO TENANT FOR ANY LOST PROFIT, DAMAGE TO OR LOSS OF BUSINESS OR ANY FORM OF SPECIAL, INDIRECT OR CONSEQUENTIAL DAMAGE. BEFORE
FILING SUIT FOR AN ALLEGED DEFAULT BY LANDLORD, TENANT SHALL GIVE LANDLORD AND THE MORTGAGEE(S) WHOM TENANT HAS BEEN NOTIFIED HOLD MORTGAGES (DEFINED IN SECTION 23 BELOW), NOTICE AND REASONABLE TIME TO CURE THE ALLEGED DEFAULT. WITHOUT LIMITING THE
FOREGOING, IN NO EVENT SHALL LANDLORD OR ANY MORTGAGEES OR LANDLORD RELATED PARTIES EVER BE LIABLE FOR ANY CONSEQUENTIAL OR INCIDENTAL DAMAGES OR ANY LOST PROFITS OF TENANT. 

21. Relocation. 
 Intentionally omitted. 

22. Holding Over. 
 If Tenant fails to surrender all or
any part of the Premises at the termination of this Lease, occupancy of the Premises after termination shall be that of a tenancy at sufferance, and in no event shall Landlord be prevented from immediate recovery of possession of the Premises by
summary proceedings or otherwise. Tenant’s occupancy shall be subject to all the terms and provisions of this Lease, and Tenant shall pay an amount (on a per month basis without reduction for partial months during the holdover) equal to 150% of
the sum of the Base Rent and Additional Rent due for the period immediately preceding the holdover. No holdover by Tenant or payment by Tenant after the termination of this Lease shall be construed to extend the Term or prevent Landlord from
immediate recovery of possession of the Premises by summary proceedings or otherwise. If Landlord is unable to deliver possession of the Premises to a new tenant or to perform improvements for a new tenant as a result of Tenant’s holdover and
Tenant fails to vacate the Premises within 30 days after notice from Landlord, Tenant shall be liable for all damages that Landlord suffers from the holdover. 

23. Subordination to Mortgages; Estoppel Certificate. 

23.01 Tenant accepts this Lease subject and subordinate to any mortgage(s), deed(s) of trust, deeds to secure debt, ground lease(s) or other
lien(s) now or subsequently arising upon the Premises, the Building or the Property, and to renewals, modifications, refinancings and extensions thereof (collectively referred to as a “Mortgage”). The party having the benefit of a
Mortgage shall be referred to as a “Mortgagee”. This clause shall be self-operative, but upon request from a Mortgagee, Tenant shall execute a commercially reasonable subordination agreement in favor of the Mortgagee. As an
alternative, a Mortgagee shall have the right at any time to subordinate its Mortgage to this Lease. Upon request, Tenant, without charge, shall attorn to any successor to Landlord’s interest in this Lease. Landlord and Tenant shall each,
within 10 days after receipt of a written request from the other, execute and deliver a commercially reasonable estoppel certificate to those parties as are reasonably requested by the other (including a Mortgagee or prospective purchaser). Without
limitation, such estoppel certificate may include a certification as to the status of this Lease, the existence of any defaults and the amount of Rent that is due and payable. 

  
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 23.02 In the event Mortgagee enforces it rights under the Mortgage, Tenant, at Mortgagee’s
option, will attorn to Mortgagee or its successor; provided, however, that Mortgagee or its successor shall not be liable for or bound by (i) any payment of any Rent installment which may have been made more than 30 days before the due date of
such installment, (ii) any act or omission of or default by Landlord under this Lease (but Mortgagee, or such successor, shall be subject to the continuing obligations of landlord under the Lease to the extent arising from and after such
succession to the extent of Mortgagee’s, or such successor’s, interest in the Property), (iii) any credits, claims, setoffs or defenses which Tenant may have against Landlord prior to the date Mortgagee enforces its rights under the
Mortgage, (iv) any modification or amendment to this Lease for which Mortgagee’s consent is required, but has not been obtained, under a Mortgage or (v) any obligation under this Lease to maintain a fitness facility at the Building,
if any. Tenant, upon the reasonable request by Mortgagee or such successor in interest, shall execute and deliver an instrument or instruments confirming such attornment. 

24. Notice. 
 All demands, approvals, consents or notices
(collectively referred to as a “notice”) shall be in writing and delivered by hand or sent by registered, express, or certified mail, with return receipt requested or with delivery confirmation requested from the U.S. postal
service, or sent by overnight or same day courier service at the party’s respective Notice Address(es) set forth in Section 1; provided, however, notices sent by Landlord regarding general Building operational matters may be posted in the
Building mailroom or the general Building newsletter or sent via e-mail to the e-mail address provided by Tenant to Landlord for such purpose. In addition, if the Building is closed (whether due to emergency, governmental order or any other reason),
then any notice address at the Building shall not be deemed a required notice address during such closure, and, unless Tenant has provided an alternative valid notice address to Landlord for use during such closure, any notices sent during such
closure may be sent via e-mail or in any other practical manner reasonably designed to ensure receipt by the intended recipient. Each notice shall be deemed to have been received on the earlier to occur of actual delivery (which, in the case of hand
delivery, may be deemed “actually delivered” by posting same on the exterior door of the Premises, if the notice is for Tenant, or Landlord’s management office, if the notice is for Landlord) or the date on which delivery is refused,
or, if Tenant has vacated the Premises or any other Notice Address of Tenant without providing a new Notice Address, 3 days after notice is deposited in the U.S. mail or with a courier service in the manner described above. Either party may, at any
time, change its Notice Address (other than to a post office box address) by giving the other party written notice of the new address. 
 25. Surrender
of Premises. 
 At the termination of this Lease or Tenant’s right of possession, Tenant shall remove Tenant’s Property from the Premises, and
quit and surrender the Premises to Landlord, broom clean, and in good order, condition and repair, ordinary wear and tear and damage by Casualty (subject to the terms of Section 16) and condemnation (subject to the terms of Section 17)
excepted which Landlord is obligated to repair hereunder excepted. If Tenant fails to remove any of Tenant’s Property, or to restore the Premises to the required condition, within 2 days after termination of this Lease or Tenant’s right to
possession, Landlord, at Tenant’s sole cost and expense, shall be entitled (but not obligated) to remove and store Tenant’s Property and/or perform such 

  
 19 








 
restoration of the Premises. Landlord shall not be responsible for the value, preservation or safekeeping of Tenant’s Property. Tenant shall pay Landlord, upon demand, the expenses and
storage charges incurred. If Tenant fails to remove Tenant’s Property from the Premises or storage, within 30 days after notice, Landlord may deem all or any part of Tenant’s Property to be abandoned and, at Landlord’s option, title
to Tenant’s Property shall vest in Landlord or Landlord may dispose of Tenant’s Property in any manner Landlord deems appropriate. 
  

	26.	Miscellaneous. 

 26.01 This Lease shall be interpreted and enforced in accordance with
the Laws of the state or commonwealth in which the Building is located and Landlord and Tenant hereby irrevocably consent to the jurisdiction and proper venue of such state or commonwealth. If any term or provision of this Lease shall to any extent
be void or unenforceable, the remainder of this Lease shall not be affected. If there is more than one Tenant or if Tenant is comprised of more than one party or entity, the obligations imposed upon Tenant shall be joint and several obligations of
all the parties and entities, and requests or demands from any one person or entity comprising Tenant shall be deemed to have been made by all such persons or entities. Notices to any one person or entity shall be deemed to have been given to all
persons and entities. Tenant represents and warrants to Landlord, and agrees, that each individual executing this Lease on behalf of Tenant is authorized to do so on behalf of Tenant and that the entity(ies) or individual(s) constituting Tenant or
Guarantor or which may own or control Tenant or Guarantor or which may be owned or controlled by Tenant or Guarantor are not and at no time will be (i) in violation of any Laws relating to terrorism or money laundering, or (ii) among the
individuals or entities identified on any list compiled pursuant to Executive Order 13224 for the purpose of identifying suspected terrorists or on the most current list published by the U.S. Treasury Department Office of Foreign Assets Control at
its official website, http://www.treasury.gov/resource-center/sanctions/SDN-List/Pages/default.aspx or any replacement website or other replacement official publication of such list. 

26.02 If Tenant fails to pay any Rent or other sum due and owing under this Lease, and such sum is thereafter collected by or through an
attorney at law, then, in addition to such sums, Tenant shall also pay Landlord’s reasonable attorneys’ fees for such collection. In any action or proceeding between Landlord and Tenant, the prevailing party shall be entitled to recover
all of its costs and expenses in connection therewith, including, but not limited to, reasonable attorneys’ fees actually incurred from the non-prevailing party; provided, however, that a recovery of attorneys’ fees by Landlord against
Tenant under this sentence shall include, but shall not duplicate, the recovery by Landlord against Tenant of its reasonable attorneys’ fees and other reasonable costs of collection permitted under the immediately preceding sentence. The phrase
“reasonable attorneys’ fees actually incurred” or phrases of similar meanings regarding attorneys fees used in this Section and other Sections of this Lease relating to the attorneys’ fees the prevailing party in any action or
proceeding is permitted to recover under the terms of this Lease shall be deemed to mean reasonable attorney’s fees, without consideration of the terms of O.C.G.A.13-1-11(a)(1) or O.C.G.A.13-1-11(a)(2), and shall be deemed to include the cost
of enforcing any term or condition of this Lease, the cost of proving all damages and the cost of proving the amount of and the reasonableness of all attorneys’ fees, including, but not limited to, the cost of any experts to prove same. In
addition, “attorneys’ fees” as used throughout this Lease shall include the fees of third party attorneys and the fees of “in house” legal counsel of Landlord and Tenant, as appropriate. Landlord and Tenant hereby waive any
right to trial by jury in any proceeding based upon a breach of this Lease. No failure by either party to declare a default immediately upon its occurrence, nor any delay by either party in taking action for a default, nor Landlord’s acceptance
of Rent with knowledge of a default by Tenant, shall constitute a waiver of the default, nor shall it constitute an estoppel. 

  
 20 








 26.03 Whenever a period of time is prescribed for the taking of an action by Landlord or Tenant
(other than the payment of the Security Deposit or Rent), the period of time for the performance of such action shall be extended by the number of days that the performance is actually delayed due to strikes, acts of God, shortages of labor or
materials, war, terrorist acts, pandemics, civil disturbances and other causes beyond the reasonable control of the performing party (“Force Majeure”). 

26.04 Landlord shall have the right to transfer and assign, in whole or in part, all of its rights and obligations under this Lease and in the
Building and Property. Upon transfer, Landlord shall be released from any further obligations hereunder and Tenant agrees to look solely to the successor in interest of Landlord for the performance of such obligations, provided that any successor
pursuant to a voluntary, third party transfer (but not as part of an involuntary transfer resulting from a foreclosure or deed in lieu thereof) shall have assumed Landlord’s obligations under this Lease from and after the date of the transfer,
and further provided that Landlord and its successors, as the case may be, shall remain liable after their respective periods of ownership with respect to any sums due in connection with a breach or default by such party that arose during such
period of ownership by such party. 
 26.05 Landlord has delivered a copy of this Lease to Tenant for Tenant’s review only and the
delivery of it does not constitute an offer to Tenant or an option. Tenant represents that it has dealt directly with and only with the Broker (described in Section 1.10) as a broker, agent or finder in connection with this Lease. Tenant shall
indemnify and hold Landlord and the Landlord Related Parties harmless from all claims of any other brokers, agents or finders claiming to have represented Tenant in connection with this Lease. Landlord shall indemnify and hold Tenant and the Tenant
Related Parties harmless from all claims of any brokers, agents or finders claiming to have represented Landlord in connection with this Lease. Equity Office Properties Management Corp., or such other entity affiliated with Equity Office Properties
Management Corp. that is involved in the negotiation of this Lease (each referred to as “EOPMC”), represents only the Landlord in this transaction. Any assistance rendered by any agent or employee of EOPMC in connection with this
Lease or any subsequent amendment or modification or any other document related hereto has been or will be made as an accommodation to Tenant solely in furtherance of consummating the transaction on behalf of Landlord, and not as agent for Tenant.
Landlord agrees to pay a brokerage commission to Tenant’s Broker and Landlord’s Broker in accordance with the terms of separate commission agreements entered into or to be entered into between Landlord and Tenant’s Broker, and
Landlord and Landlord’s Broker, respectively, provided that in no event shall Landlord be obligated to pay a commission to Tenant’s Broker or Landlord’s Broker in connection with any extension of the Term or in connection with any
additional space that is leased by Tenant pursuant to the terms of this Lease except as may be specifically provided otherwise in such agreement or future agreement between Landlord and Tenant’s Broker, and Landlord and Landlord’s Broker,
respectively. 
 26.06 Time is of the essence with respect to payment of Rent and Tenant’s exercise of any expansion, renewal or
extension rights granted to Tenant. The expiration of the Term, whether by lapse of time, termination or otherwise, shall not relieve either party of any obligations which accrued prior to or which may continue to accrue after the expiration or
termination of this Lease. 

  
 21 








 26.07 Tenant may peacefully have, hold and enjoy the Premises, subject to the terms of this
Lease, provided Tenant pays the Rent and fully performs all of its covenants and agreements. This covenant shall be binding upon Landlord and its successors only during its or their respective periods of ownership of the Building. 

26.08 This Lease does not grant any rights to light or air over or about the Building. Landlord excepts and reserves exclusively to itself any
and all rights not specifically granted to Tenant under this Lease. Landlord reserves the right to make changes to the Property, Building and Common Areas as Landlord deems appropriate, provided the changes do not materially adversely affect
Tenant’s ability to use the Premises for the Permitted Use. This Lease constitutes the entire agreement between the parties and supersedes all prior agreements and understandings related to the Premises, including all lease proposals, letters
of intent and other documents. Neither party is relying upon any warranty, statement or representation not contained in this Lease. This Lease may be modified only by a written agreement signed by an authorized representative of Landlord and Tenant.
Wherever this Lease requires Landlord to provide a customary service or to act in a reasonable manner (whether in incurring an expense, establishing a rule or regulation, providing an approval or consent, or performing any other act), this Lease
shall be deemed also to provide that whether such service is customary or such conduct is reasonable shall be determined by reference to the practices of owners of buildings that (i) are comparable to the Building in size, age, class, quality
and location, and (ii) at Landlord’s option, have been, or are being prepared to be, certified under the U.S. Green Building Council’s Leadership in Energy and Environmental Design (LEED) rating system or a similar rating system. 

26.09 Submission of this Lease by Landlord is not an offer to enter into this Lease but rather is a solicitation for such an offer by Tenant.
Landlord shall not be bound by this Lease until Landlord has executed and delivered the same to Tenant. Tenant agrees that its execution of this Lease constitutes a firm offer to enter the same, which may not be withdrawn for a period of 15 days
after delivery to Landlord (or such other period as may be expressly provided in any other agreement signed by the parties). 
 26.10 If
Landlord is advised by its counsel at any time that any part of the payments by Tenant to Landlord under this Lease may be characterized as unrelated business income under the United States Internal Revenue Code and its regulations, then Tenant
shall enter into any amendment proposed by Landlord to avoid such income, so long as the amendment does not require Tenant to make more payments or accept fewer services from Landlord, than this Lease provides. 

26.11 This Lease may be executed in counterparts and shall constitute an agreement binding on all parties notwithstanding that all parties are
not signatories to the original or the same counterpart provided that all parties are furnished a copy or copies thereof reflecting the signature of all parties. Transmission of a facsimile or by email of a pdf copy of the signed counterpart of the
Lease shall be deemed the equivalent of the delivery of the original, and any party so delivering a facsimile or pdf copy of the signed counterpart of the Lease by email transmission shall in all events deliver to the other party an original
signature promptly upon request. 
 26.12 Tenant has only a usufruct, not subject to purchase or sale, which may not be assigned by Tenant
except as expressly provided in this Lease. 

  
 22 








 Landlord and Tenant have executed this Lease under seal in two or more counterparts as of the day
and year first above written. 
  

			
	LANDLORD:
	
	BRE/COH GA LLC, a Delaware limited liability company
		
	By:	 	 /s/ Mark W. Smith

	Name:	 	 Mark W. Smith

	Title:	 	 Managing Director

	
	TENANT:
	
	CLEARSIDE BIOMEDICAL, INC., a Delaware corporation
		
	By:	 	 /s/ Daniel H. White

	Name:	 	 Daniel H. White

	Title:	 	 President & CEO




  
 23 








 EXHIBIT A-1 

OUTLINE AND LOCATION OF PREMISES 

This Exhibit is attached to and made a part of the Office Lease Agreement (the “Lease”) by and between BRE/COH GA LLC, a
Delaware limited liability company (“Landlord”), and CLEARSIDE BIOMEDICAL, INC., a Delaware corporation (“Tenant”), for space in the Building located at 900 North Point Parkway, Alpharetta, Georgia 30005.

  
 



 

  
 A-1 








 EXHIBIT A-2 

OUTLINE AND LOCATION OF REFUSAL SPACE 

This Exhibit is attached to and made a part of the Office Lease Agreement (the “Lease”) by and between BRE/COH GA LLC, a
Delaware limited liability company (“Landlord”), and CLEARSIDE BIOMEDICAL, INC., a Delaware corporation (“Tenant”), for space in the Building located at 900 North Point Parkway, Alpharetta, Georgia 30005.

  
 



 

  
 A-2 








 EXHIBIT A-3 

OUTLINE AND LOCATION OF DEFERRED SPACE 

This Exhibit is attached to and made a part of the Office Lease Agreement (the “Lease”) by and between BRE/COH GA LLC, a
Delaware limited liability company (“Landlord”), and CLEARSIDE BIOMEDICAL, INC., a Delaware corporation (“Tenant”), for space in the Building located at 900 North Point Parkway, Alpharetta, Georgia 30005.

  
 



 

  
 A-3 








 EXHIBIT B 

EXPENSES AND TAXES 

This Exhibit is attached to and made a part of the Office Lease Agreement (the “Lease”) by and between BRE/COH GA LLC, a
Delaware limited liability company (“Landlord”), and CLEARSIDE BIOMEDICAL, INC., a Delaware corporation (“Tenant”), for space in the Building located at 900 North Point Parkway, Alpharetta, Georgia 30005.
Capitalized terms used but not defined herein shall have the meanings given in the Lease. 
 1. Payments. 

1.01 Tenant shall pay Tenant’s Pro Rata Share of the amount, if any, by which Expenses (defined below) for each calendar year during the Term exceed
Expenses for the Base Year (the “Expense Excess”) and also the amount, if any, by which Taxes (defined below) for each calendar year during the Term exceed Taxes for the Base Year (the “Tax Excess”). If Expenses or
Taxes in any calendar year decrease below the amount of Expenses or Taxes for the Base Year, Tenant’s Pro Rata Share of Expenses or Taxes, as the case may be, for that calendar year shall be $0. Landlord shall provide Tenant with a good faith
estimate of the Expense Excess and of the Tax Excess for each calendar year during the Term. On or before the first day of each month, Tenant shall pay to Landlord a monthly installment equal to one-twelfth of Tenant’s Pro Rata Share of
Landlord’s estimate of both the Expense Excess and Tax Excess. If, not more than twice per calendar year, Landlord determines that its good faith estimate of the Expense Excess or of the Tax Excess was incorrect by a material amount, Landlord
may provide Tenant with a revised estimate. After its receipt of the revised estimate, Tenant’s monthly payments shall be based upon the revised estimate. If Landlord does not provide Tenant with an estimate of the Expense Excess or the Tax
Excess by January 1 of a calendar year, Tenant shall continue to pay monthly installments based on the previous year’s estimate(s) until Landlord provides Tenant with the new estimate. Upon delivery of the new estimate, an adjustment shall
be made for any month for which Tenant paid monthly installments based on the previous year’s estimate. Tenant shall pay Landlord the amount of any underpayment within 30 days after receipt of the new estimate. Any overpayment shall be refunded
to Tenant within 30 days or credited against the next due future installment(s) of Additional Rent. 
 1.02 As soon as is practical following the end of
each calendar year, Landlord shall furnish Tenant with a statement of the actual Expenses and Expense Excess and the actual Taxes and Tax Excess for the prior calendar year. Landlord shall use reasonable efforts to furnish the statement of actual
Expenses on or before June 1 of the calendar year immediately following the calendar year to which the statement applies. If the estimated Expense Excess or estimated Tax Excess for the prior calendar year is more than the actual Expense Excess
or actual Tax Excess, as the case may be, for the prior calendar year, Landlord shall either provide Tenant with a refund or apply any overpayment by Tenant against Additional Rent due or next becoming due, provided if the Term expires before the
determination of the overpayment, Landlord shall refund any overpayment to Tenant after first deducting the amount of Rent due. If the estimated Expense Excess or estimated Tax Excess for the prior calendar year is less than the actual Expense
Excess or actual Tax Excess, as the case may be, for such prior year, Tenant shall pay Landlord, within 30 days after its receipt of the statement of Expenses or Taxes, any underpayment for the prior calendar year. 

  
 B-1 








 2. Expenses. 

2.01 “Expenses” means all costs and expenses incurred in each calendar year in connection with operating, maintaining, repairing, and
managing the Building and the Property. Landlord agrees to act in a commercially reasonable manner in incurring Expenses, taking into consideration the class and the quality of the Building. “Expenses” shall include, but not be limited to:
(a) all labor and labor related costs, including wages, salaries, bonuses, taxes, insurance, uniforms, training, retirement plans, pension plans and other employee benefits; (b) management fees in an amount equal to 3% of the gross
revenues from the Building and the Property; (c) the cost of equipping, staffing and operating an on-site and/or off-site management office for the Building, provided if the management office services one or more other buildings or properties,
the shared costs and expenses of equipping, staffing and operating such management office(s) shall be equitably prorated and apportioned between the Building and the other buildings or properties; (d) accounting costs; (e) the cost of
services used in the maintenance, repair and operation of the Building and/or the Property; (f) rental and purchase cost of parts, supplies, tools and equipment; (g) insurance premiums and deductibles; (h) electricity, gas and other
utility costs; and (i) the amortized cost of capital improvements (as distinguished from replacement parts or components installed in the ordinary course of business) made subsequent to the Base Year which are: (1) intended to effect
economies in the operation or maintenance of the Property, reduce current or future Expenses, enhance the safety or security of the Property or its occupants, or enhance the environmental sustainability of the Property’s operations,
(2) replacements or modifications of nonstructural items located in the Base Building or Common Areas that are required to keep the Base Building or Common Areas in good condition, or (3) required under any Law. The cost of capital
improvements shall be amortized by Landlord over the lesser of the Payback Period (defined below) or the useful life of the capital improvement as reasonably determined by Landlord. The amortized cost of capital improvements may, at Landlord’s
option, include actual or imputed interest at the rate that Landlord would reasonably be required to pay to finance the cost of the capital improvement. “Payback Period” means the reasonably estimated period of time that it takes
for the cost savings resulting from a capital improvement to equal the total cost of the capital improvement. Landlord, by itself or through an affiliate, shall have the right to directly perform, provide and be compensated for any services under
the Lease. If Landlord incurs Expenses for the Building or Property together with one or more other buildings or properties, whether pursuant to a reciprocal easement agreement, common area agreement or otherwise, the shared costs and expenses shall
be equitably prorated and apportioned between the Building and Property and the other buildings or properties. 
 2.02 Expenses shall not include: the cost
of capital improvements (except as set forth above); depreciation; principal payments of mortgage and other non-operating debts of Landlord; the cost of repairs or other work to the extent Landlord is reimbursed by insurance or condemnation
proceeds; costs in connection with leasing space in the Building, including brokerage commissions; lease concessions, rental abatements and construction allowances granted to specific tenants; costs incurred in connection with the sale, financing or
refinancing of the Building, including brokerage commissions, attorneys’ and accountants’ fees, closing costs, title insurance premiums, transfer taxes and interest charges; fines, interest and penalties incurred due to the late payment of
Taxes or Expenses; organizational expenses associated with the creation and operation of the entity which constitutes Landlord; wages, salaries, fees, and fringe benefits (“Labor Costs”) paid to executive personnel or officers or
partners of Landlord, except that if such individuals provide services directly related to the operation, maintenance or 

  
 B-2 








 
ownership of the Building which, if provided directly by a general manager/property manager or its general support staff, would normally be chargeable as an operating expense of a comparable
office Building, then an appropriate pro rata share of the Labor Costs of such individuals that is reflective of the extent to which such individuals are providing such services to the Building may be included in Expenses; all costs of purchasing or
leasing major sculptures, paintings or other major works or objects of art (as opposed to decorations purchased or leased by Landlord for display in the Common Areas of the Building); Landlord’s charitable and political contributions;
advertising and promotional expenditures; costs incurred by Landlord in connection with the correction of defects in design and original construction of the Building or Property; reserves not spent by Landlord by the end of the calendar year for
which Expenses are paid; sums (other than management fees, it being agreed that the management fees included in Expenses are as described in Section 2.01 above) paid to subsidiaries or other affiliates of Landlord for services on or to the
Property, Building and/or Premises, but only to the extent that the costs of such services exceed the competitive cost for such services rendered by persons or entities of similar skill, competence and experience; fines or penalties incurred as a
result of violation by Landlord of any applicable Laws; or any penalties or damages that Landlord pays to Tenant under this Lease or to other tenants in the Building under their respective leases. 

2.03 If at any time during a calendar year the Building is not at least 95% occupied (or a service provided by Landlord to tenants of the Building generally
is not provided by Landlord to a tenant that provides such service itself, or any tenant of the Building is entitled to free rent, rent abatement or the like), Expenses shall, at Landlord’s option, be determined as if the Building had been 95%
occupied (and all services provided by Landlord to tenants of the Building generally had been provided by Landlord to all tenants, and no tenant of the Building had been entitled to free rent, rent abatement or the like) during that calendar year.
If Expenses for a calendar year are determined as provided in the prior sentence, Expenses for the Base Year shall also be determined in such manner. Notwithstanding the foregoing, Landlord may calculate the extrapolation of Expenses under this
Section based on 100% occupancy and service so long as such percentage is used consistently for each year of the Term. The extrapolation of Expenses under this Section shall be performed in accordance with the methodology specified by the Building
Owners and Managers Association. 
 3. “Taxes” shall mean: (a) all real property taxes and other assessments on the Building and/or
Property, including, but not limited to, gross receipts taxes, assessments for special improvement districts, community improvement districts and building improvement districts, governmental charges, fees and assessments for police, fire, traffic
mitigation or other governmental service of purported benefit to the Property, taxes and assessments levied in substitution or supplementation in whole or in part of any such taxes and assessments and the Property’s share of any real estate
taxes and assessments under any reciprocal easement agreement, common area agreement or similar agreement as to the Property; (b) all personal property taxes for property that is owned by Landlord and used in connection with the operation,
maintenance and repair of the Property; and (c) all costs and fees incurred in connection with seeking reductions in any tax liabilities described in (a) and (b), including, without limitation, any costs incurred by Landlord for
compliance, review and appeal of tax liabilities. Without limitation, Taxes shall be determined without regard to any “green building” credit and shall not include any income, capital levy, transfer, capital stock, gift, estate or
inheritance tax, or any fines, interest or penalties incurred due to the late payment of Taxes. If a change in Taxes is obtained for any year of the Term during which Tenant paid Tenant’s Pro Rata Share of any Tax


  
 B-3 








 
Excess, then Taxes for that year will be retroactively adjusted and Landlord shall provide Tenant with a credit, if any, based on the adjustment. Likewise, if a change is obtained for Taxes for
the Base Year, Taxes for the Base Year shall be restated and the Tax Excess for all subsequent years shall be recomputed. Tenant shall pay Landlord the amount of Tenant’s Pro Rata Share of any such increase in the Tax Excess within 30 days
after Tenant’s receipt of a statement from Landlord. 
 4. Audit Rights. Within 60 days after receiving Landlord’s statement of Expenses
(or, with respect to the Base Year Expenses, within 90 days after receiving Landlord’s initial statement of Expenses for the Base Year) (each such period is referred to as the “Review Notice Period”), Tenant may give Landlord
written notice (“Review Notice”) that Tenant intends to review Landlord’s records of the Expenses for the calendar year (or Base Year, as applicable) to which the statement applies, and within 60 days after sending the Review
Notice to Landlord (such period is referred to as the “Request for Information Period”), Tenant shall send Landlord a written request identifying, with a reasonable degree of specificity, the information that Tenant desires to
review (the “Request for Information”). Within a reasonable time after Landlord’s receipt of a timely Request for Information and executed Audit Confidentiality Agreement (referenced below), Landlord, as determined by Landlord,
shall forward to Tenant, or make available for inspection on site at such location deemed reasonably appropriate by Landlord, such records (or copies thereof) for the applicable calendar year (or Base Year, as applicable) that are reasonably
necessary for Tenant or its appointed agent to conduct its review of the information appropriately identified in the Request for Information. Within 60 days after any particular records are made available to Tenant (such period is referred to as the
“Objection Period”), Tenant shall have the right to give Landlord written notice (an “Objection Notice”) stating in reasonable detail any objection to Landlord’s statement of Expenses for that year which
relates to the records that have been made available to Tenant. If Tenant provides Landlord with a timely Objection Notice, Landlord and Tenant shall work together in good faith to resolve any issues raised in Tenant’s Objection Notice. If
Landlord and Tenant determine that Expenses for the calendar year are less than reported, Landlord shall provide Tenant with a credit against the next installment of Rent in the amount of the overpayment by Tenant. Likewise, if Landlord and Tenant
determine that Expenses for the calendar year are greater than reported, Tenant shall pay Landlord the amount of any underpayment within 30 days. If Tenant fails to give Landlord an Objection Notice with respect to any records that have been made
available to Tenant prior to expiration of the Objection Period applicable to the records which have been provided to Tenant, Tenant shall be deemed to have approved Landlord’s statement of Expenses with respect to the matters reflected in such
records and shall be barred from raising any claims regarding the Expenses relating to such records for that year. If Tenant fails to provide Landlord with a Review Notice prior to expiration of the Review Notice Period or fails to provide Landlord
with a Request for Information prior to expiration of the Request for Information Period described above, Tenant shall be deemed to have approved Landlord’s statement of Expenses and shall be barred from raising any claims regarding the
Expenses for that year. 
 If Tenant retains an agent to review Landlord’s records, the agent must be with a CPA firm licensed to do business in the
state or commonwealth where the Property is located. Notwithstanding the foregoing, Landlord agrees that Tenant may retain a third party agent to review Landlord’s books and records which is not a CPA firm, so long as the third party agent
retained by Tenant shall have expertise in and familiarity with general industry practice with respect to the operation of and accounting for a first class office building and whose 

  
 B-4 








 
compensation shall in no way be contingent upon or correspond to the financial impact on Tenant resulting from the review. Tenant shall be solely responsible for all costs, expenses and fees
incurred for the audit, and the fees charged cannot be based in whole or in part on a contingency basis. However, notwithstanding the foregoing, if Landlord and Tenant determine that Expenses for the Building for the year in question were less than
stated by more than 5%, Landlord, within 30 days after its receipt of paid invoices therefor from Tenant, shall reimburse Tenant for the reasonable amounts paid by Tenant to third parties in connection with such review by Tenant. The records
and related information obtained by Tenant shall be treated as confidential, and applicable only to the Building, by Tenant and its auditors, consultants and other parties reviewing such records on behalf of Tenant (collectively,
“Tenant’s Auditors”), and, prior to making any records available to Tenant or Tenant’s Auditors, Landlord may require Tenant and Tenant’s Auditors to each execute a reasonable confidentiality agreement (“Audit
Confidentiality Agreement”) in accordance with the foregoing. In no event shall Tenant be permitted to examine Landlord’s records or to dispute any statement of Expenses unless Tenant has paid and continues to pay all Rent when due.


  
 B-5 








 EXHIBIT C 

WORK LETTER 
 This
Exhibit is attached to and made a part of the Office Lease Agreement (the “Lease”) by and between BRE/COH GA LLC, a Delaware limited liability company (“Landlord”), and CLEARSIDE BIOMEDICAL, INC., a
Delaware corporation (“Tenant”), for space in the Building located at 900 North Point Parkway, Alpharetta, Georgia 30005. Capitalized terms used but not defined herein shall have the meanings given in the Lease. 

As used in this Work Letter, the “Premises” shall be deemed to mean the Premises and the Deferred Space, as initially defined in the attached
Lease. 
  

	1.	Landlord Work. 

  

	 	1.01	This Work Letter shall set forth the obligations of Landlord and Tenant with respect to the improvements to be performed in the Premises for Tenant’s use. All improvements described in this Work Letter to be
constructed in and upon the Premises by Landlord are hereinafter referred to as the “Landlord Work”. It is agreed that construction of the Landlord Work will be completed at Tenant’s sole cost and expense, subject to the
Allowance (as defined below). Landlord shall enter into a direct contract for the Landlord Work with a general contractor selected by Landlord. At least one general contractor that bids on the Landlord Work shall be selected by Tenant provided that
such general contractor is reasonably acceptable to Landlord. In addition, Landlord shall have the right to select and/or approve of any subcontractors used in connection with the Landlord Work. Tenant and Landlord agree that Landlord is not
responsible and is not performing any alterations, repairs or improvements in the Premises with respect to the telephone and data cabling, infrastructure (e.g., coring the floors, or making structural alterations to the Premises), or any HVAC
supplemental cooling, if any, nor shall Landlord be responsible for purchasing or installing furniture or equipment in the Premises. 

  

	 	1.02	 Landlord’s architect shall prepare the final architectural, electrical and mechanical construction drawings,
plans and specifications (called “Plans”) necessary to construct the Landlord Work, which plans shall be subject to approval by Landlord and Tenant, and which approval shall not be unreasonably withheld, conditioned or delayed.
Notwithstanding the foregoing, Tenant shall be responsible for all elements of the design of Tenant’s plans with respect to functionality of design, the configuration of the Leased Premises and the placement of Tenant’s furniture,
appliances and equipment, and Landlord’s approval of Tenant’s plans shall in no event relieve Tenant of the responsibility for such design. Tenant shall advise Landlord within 3 Business Days after receipt of the Plans of its approval or
disapproval thereof, and if Tenant does not approve any of the Plans, of the changes required so that they will meet Tenant’s approval. If Tenant disapproves of any of the Plans, Landlord shall deliver or cause the Landlord’s architect to
deliver to Tenant revised Plans which respond to Tenant’s reasonable requests for changes. Tenant shall advise Landlord within 2 Business Days after receipt of any revised Plans of its approval or




  
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disapproval thereof, and if Tenant does not approve any of the revised Plans, of the changes required so that they will meet Tenant’s approval. This iterative process shall continue until
Landlord and Tenant mutually agree upon the final Plans for the Landlord Work. If Tenant fails to respond in writing (including email) with its approval or disapproval of any such Plans within the applicable period set forth above, then the
applicable Plans shall be deemed approved by Tenant. Time is of the essence in respect of the review of the Plans by Tenant. 

  

	 	1.03	If Landlord’s estimate and/or the actual cost of construction shall exceed the Allowance, Landlord, prior to commencing any construction of Landlord Work, shall submit to Tenant a written estimate setting forth the
anticipated cost of the Landlord Work, including but not limited to labor and materials, contractor’s fees and permit fees. Within 3 Business Days thereafter, Tenant shall either notify Landlord in writing of its approval of the cost estimate,
or specify its objections thereto and any desired changes to the proposed Landlord Work. If Tenant notifies Landlord of such objections and desired changes, Tenant shall work with Landlord to reach a mutually acceptable alternative cost estimate.


  

	 	1.04	If Landlord’s estimate and/or the actual cost of construction shall exceed the Allowance, if any (such amounts exceeding the Allowance being herein referred to as the “Excess Costs”), Tenant shall
pay to Landlord such Excess Costs, plus any applicable state sales or use tax thereon, upon demand. The statements of costs submitted to Landlord by Landlord’s contractors shall be conclusive for purposes of determining the actual cost of the
items described therein. The amounts payable by Tenant hereunder constitute Rent payable pursuant to the Lease, and the failure to timely pay same constitutes an event of default under the Lease. 


 

	 	1.05	If Tenant shall request any change, addition or alteration in any of the Plans after approval by Landlord, Landlord shall have such revisions to the drawings prepared, and Tenant shall reimburse Landlord for the cost
thereof, plus any applicable state sales or use tax thereon, upon demand. Promptly upon completion of the revisions, Landlord shall notify Tenant in writing of the increased cost which will be chargeable to Tenant by reason of such change, addition
or deletion. Tenant, within two (2) Business Days, shall notify Landlord in writing whether it desires to proceed with such change, addition or deletion. In the absence of such written authorization, Landlord shall have the option to continue
work on the Premises disregarding the requested change, addition or alteration, or Landlord may elect to discontinue work on the Premises until it receives notice of Tenant’s decision, in which event Tenant shall be responsible for any Tenant
Delay in completion of the Premises resulting therefrom. If such revisions result in a higher estimate of the cost of construction and/or higher actual construction costs which exceed the Allowance, such increased estimate or costs shall be deemed
Excess Costs pursuant to Section 1.04 hereof and Tenant shall pay such Excess Costs, plus any applicable state sales or use tax thereon, upon demand. 

  

	 	1.06	Following approval of the Plans and the payment by Tenant of the required portion of the Excess Costs, if any, Landlord shall cause the Landlord Work to be constructed substantially in accordance with the approved
Plans. Landlord shall notify Tenant of substantial completion of the Landlord Work. 


  
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	 	1.07	Landlord, provided Tenant is not in default under the Lease or this Work Letter, agrees to provide Tenant with an allowance (the “Allowance”) in an amount not to exceed $679,296.45 to be applied toward
the cost of the Landlord Work in the Premises. If the Allowance shall not be sufficient to complete the Landlord Work, Tenant shall pay the Excess Costs, plus any applicable state sales or use tax thereon, as prescribed in Section 1.04 above.
Any portion of the Allowance which exceeds the cost of the Landlord Work or is otherwise remaining after June 30, 2017, shall accrue to the sole benefit of Landlord, it being agreed that Tenant shall not be entitled to any credit, offset,
abatement or payment with respect thereto. Landlord shall be entitled to deduct from the Allowance a construction management fee for Landlord’s oversight of the Landlord Work in an amount equal to 3% of the total hard costs of the Landlord
Work. 

 Upon completion of the Landlord Work and payment of all costs related thereto, and provided Tenant is not in Default
under the Lease, Tenant may request that Landlord apply up to $93,720.00 of the Unused Allowance (the “Credit Allowance”) against: 
  

	 	(a)	Tenant’s Moving Costs (described below). Landlord shall disburse such portion of the Credit Allowance requested by Tenant for such purpose within 30 days after Landlord’s receipt of paid invoices from
Tenant with respect to Tenant’s actual Moving Costs; and/or 

  

	 	(b)	Tenant’s FF&E Costs (described below). Landlord shall disburse such portion of the Credit Allowance requested by Tenant for such purpose within 30 days after Landlord’s receipt of invoices from Tenant
with respect to Tenant’s actual FF&E Costs, provided, however, Tenant agrees that any portion of the Credit Allowance (or any other portion of the Allowance) disbursed to Tenant for FF&E Costs shall be treated as income to Tenant and
Tenant further acknowledges that Landlord may issue a 1099-Misc in connection with such matter. 

 Tenant’s
“Moving Costs” shall mean the costs and expenses incurred by Tenant for the cost of moving from its existing location into the Premises, including moving costs and the cost to move and install Tenant’s furniture and equipment,
including telephone, data and computer equipment and cabling, related to Tenant’s occupancy of the Premises. 
 Tenant’s
“FF&E Costs” shall mean the costs and expenses incurred by Tenant in purchasing any furniture, equipment or other personalty for the Premises and/or the cost to move and install same in the Premises. 

In no event shall Landlord have any obligation to apply any portion of the Allowance against Tenant’s Moving Costs, FF&E Costs or the
Rent after June 30, 2017 (the “Unused Allowance Deadline”), it being agreed that Tenant shall not be entitled to any credit, offset, abatement or payment with respect thereto after the Unused Allowance Deadline. 

  
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	2.	Corridor Work. In addition to the Landlord Work and the Conference Room Work (as defined below), Landlord, at Landlord’s sole cost and expense shall perform certain corridor work in the Common Area
corridor adjacent to the Premises using Building standard methods, materials and finishes (the “Corridor Work”). The scope of the Corridor Work shall be determined by Landlord in Landlord’s sole discretion; provided that in no
event shall the Corridor Work include any work on the interior portion of the Premises. Landlord shall use its commercially reasonable efforts to complete the Corridor Work prior to the Commencement Date (the “Corridor Work Completion
Date”). Landlord and Tenant acknowledge that Tenant may occupy the Premises at the same time that Landlord is performing the Corridor Work. Tenant further acknowledges that some interference and impairment of Tenant’s rights of
peaceful possession and occupancy is inevitable while performance of the Corridor Work is pending and Tenant hereby consents to such interference and impairment of peaceful possession and occupancy resulting from performance of the Corridor Work.
Tenant acknowledges and agrees that it shall not be entitled to any reduction or abatement of Rent due to any interference or impairment of peaceful possession and occupancy which Tenant may suffer due to the performance of the Corridor Work.
Furthermore, the presence of Landlord and its agents, employees or contractors in the Common Area for the purpose of performing the Corridor Work shall not constitute an actual or constructive eviction, in whole or in part, or relieve Tenant of any
of its obligations under the Lease, or impose any other liability upon Landlord or its agents, employees or contractors. 

  

	3.	Conference Room Work. In addition to the Landlord Work and the Corridor Work, Landlord, at Landlord’s sole cost and expense shall construct a 50-person training/conference room (the
“Conference Room”) on the 1st floor of the Building (the “Conference Room Work”) using Building standard methods, materials and finishes. The scope of the
Conference Room Work shall be determined by Landlord in Landlord’s sole discretion. Notwithstanding the foregoing, the Conference Room shall include Building standard finishes, audio/visual projector equipment standard in current Class A
office space in the North Fulton submarket, and seating to accommodate 50 people. Subject to events of Force Majeure and any delays caused by Tenant, Landlord shall complete the Conference Room Work prior to the date (the “Conference Room
Completion Date”) which is 120 days after the Commencement Date of this Lease. 

  

	4.	This Exhibit shall not be deemed applicable to any additional space added to the Premises at any time or from time to time, whether by any options under the Lease or otherwise, or to any portion of the original Premises
or any additions to the Premises in the event of a renewal or extension of the original Term of the Lease, whether by any options under the Lease or otherwise, unless expressly so provided in the Lease or any amendment or supplement to the Lease.



  
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 EXHIBIT D 

COMMENCEMENT LETTER 

(EXAMPLE) 
  

					
	Date	 	  
	  	
			
	Tenant	 	  
	  	
	Address	 	  
	  	
		 	  
	  	
		 	  
	  	

  

	Re:	Commencement Letter with respect to that certain Lease dated as of             , 2016, by and between BRE/COH GA LLC, a Delaware limited liability
company, as Landlord, and CLEARSIDE BIOMEDICAL, INC., a Delaware corporation, as Tenant, for 18,744 rentable square feet on the 2nd floor of the Building located at 900 North
Point Parkway, Alpharetta, Georgia 30005. 

 Lease Id:
                     
 Business
Unit Number:                      
 Dear
                    : 
 In
accordance with the terms and conditions of the above referenced Lease, Tenant accepts possession of the Premises and acknowledges: 
  

	 	1.	The Commencement Date of the Lease is                     ; 


 

	 	2.	The Termination Date of the Lease is                     . 


Please acknowledge the foregoing and your acceptance of possession by signing all 3 counterparts of this Commencement Letter in the space
provided and returning 2 fully executed counterparts to my attention. Tenant’s failure to execute and return this letter, or to provide written objection to the statements contained in this letter, within 30 days after the date of this letter
shall be deemed an approval by Tenant of the statements contained herein. 
  

	
	Sincerely,
	
	  

	Authorized Signatory
	
	Acknowledged and Accepted:

  

							
		  	Tenant:	  	  
	  	
				
		  	By:	  	  
	  	
		  	Name:	  	  
	  	
		  	Title:	  	  
	  	
		  	Date:	  	  
	  	


  
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 EXHIBIT E 

BUILDING RULES AND REGULATIONS 

This Exhibit is attached to and made a part of the Office Lease Agreement (the “Lease”) by and between BRE/COH GA LLC, a
Delaware limited liability company (“Landlord”), and CLEARSIDE BIOMEDICAL, INC., a Delaware corporation (“Tenant”), for space in the Building located at 900 North Point Parkway, Alpharetta, Georgia 30005.
Capitalized terms used but not defined herein shall have the meanings given in the Lease. 
 The following rules and regulations shall
apply, where applicable, to the Premises, the Building, the parking facilities (if any), the Property and the appurtenances. In the event of a conflict between the following rules and regulations and the remainder of the terms of the Lease, the
remainder of the terms of the Lease shall control. 
 1. Sidewalks, doorways, vestibules, halls, stairways and other similar areas shall not
be obstructed by Tenant or used by Tenant for any purpose other than ingress and egress to and from the Premises. No rubbish, litter, trash, or material shall be placed, emptied, or thrown in those areas. At no time shall Tenant permit Tenant’s
employees to loiter in Common Areas or elsewhere about the Building or Property. 
 2. Plumbing fixtures and appliances shall be used only
for the purposes for which designed and no sweepings, rubbish, rags or other unsuitable material shall be thrown or placed in the fixtures or appliances. 

3. No signs, advertisements or notices shall be painted or affixed to windows, doors or other parts of the Building, except those of such
color, size, style and in such places as are first approved in writing by Landlord. All tenant identification and suite numbers at the entrance to the Premises shall be installed by Landlord, at Tenant’s cost and expense, using the standard
graphics for the Building. Except in connection with the hanging of lightweight pictures and wall decorations, no nails, hooks or screws shall be inserted into any part of the Premises or Building except by the Building maintenance personnel without
Landlord’s prior approval, which approval shall not be unreasonably withheld. 
 4. Landlord may provide and maintain in the first
floor (main lobby) of the Building an alphabetical directory board or other directory device listing tenants and no other directory shall be permitted unless previously consented to by Landlord in writing. 

5. Tenant shall not place any lock(s) on any door in the Premises or Building without Landlord’s prior written consent, which consent
shall not be unreasonably withheld, and Landlord shall have the right at all times to retain and use keys or other access codes or devices to all locks within and into the Premises. A reasonable number of keys to the locks on the entry doors in the
Premises shall be furnished by Landlord to Tenant at Tenant’s cost and Tenant shall not make any duplicate keys. All keys shall be returned to Landlord at the expiration or early termination of the Lease. 

6. All contractors, contractor’s representatives and installation technicians performing work in the Building shall be subject to
Landlord’s prior approval, which approval shall not be unreasonably withheld, and shall be required to comply with Landlord’s standard 

  
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rules, regulations, policies and procedures, which may be revised from time to time. Landlord has no obligation to allow any particular telecommunication service provider to have access to the
Building or to the Premises. If Landlord permits access, Landlord may condition the access upon the payment to Landlord by the service provider of fees assessed by Landlord in Landlord’s sole discretion. 

7. Movement in or out of the Building of furniture or office equipment, or dispatch or receipt by Tenant of merchandise or materials requiring
the use of elevators, stairways, lobby areas or loading dock areas, shall be performed in a manner and restricted to hours reasonably designated by Landlord. Tenant shall obtain Landlord’s prior approval by providing a detailed listing of the
activity, including the names of any contractors, vendors or delivery companies, which approval shall not be unreasonably withheld. Tenant shall assume all risk for damage, injury or loss in connection with the activity. 

8. Landlord shall have the right to approve the weight, size, or location of heavy equipment or articles in and about the Premises, which
approval shall not be unreasonably withheld; provided that approval by Landlord shall not relieve Tenant from liability for any damage in connection with such heavy equipment or articles. 

9. Corridor doors, when not in use, shall be kept closed. 

10. Tenant shall not: (a) make or permit any improper, objectionable or unpleasant noises or odors in the Building, or otherwise
interfere in any way with other tenants or persons having business with them; (b) solicit business or distribute or cause to be distributed, in any portion of the Building, handbills, promotional materials or other advertising; or
(c) conduct or permit other activities in the Building that might, in Landlord’s sole opinion, constitute a nuisance. 
 11. No
animals, except those assisting handicapped persons, shall be brought into the Building or kept in or about the Premises. 
 12. No
inflammable, explosive or dangerous fluids or substances shall be used or kept by Tenant in the Premises, Building or about the Property, except for those substances as are typically found in similar premises used for general office purposes and are
being used by Tenant in a safe manner and in accordance with all applicable Laws. Tenant shall not, without Landlord’s prior written consent, use, store, install, spill, remove, release or dispose of, within or about the Premises or any other
portion of the Property, any asbestos-containing materials or any solid, liquid or gaseous material now or subsequently considered toxic or hazardous under the provisions of 42 U.S.C. Section 9601 et seq., or any other applicable environmental
Law which may now or later be in effect. Tenant shall comply with all Laws pertaining to and governing the use of these materials by Tenant and shall remain solely liable for the costs of abatement and removal. 

13. Tenant shall not use or occupy the Premises in any manner or for any purpose which might injure the reputation or impair the present or
future value of the Premises or the Building. Tenant shall not use, or permit any part of the Premises to be used for lodging, sleeping or for any illegal purpose. 

  
 E-2 








 14. Tenant shall not take any action which would violate Landlord’s labor contracts or which
would cause a work stoppage, picketing, labor disruption or dispute or interfere with Landlord’s or any other tenant’s or occupant’s business or with the rights and privileges of any person lawfully in the Building (“Labor
Disruption”). Tenant shall take the actions necessary to resolve the Labor Disruption, and shall have pickets removed and, at the request of Landlord, immediately terminate any work in the Premises that gave rise to the Labor Disruption,
until Landlord gives its written consent for the work to resume. Tenant shall have no claim for damages against Landlord or any of the Landlord Related Parties nor shall the Commencement Date of the Term be extended as a result of the above actions.

 15. Tenant shall not install, operate or maintain in the Premises or in any other area of the Building, electrical equipment that would
overload the electrical system beyond its capacity for proper, efficient and safe operation as determined solely by Landlord. Tenant shall not furnish cooling or heating to the Premises, including, without limitation, the use of electric or gas
heating devices, without Landlord’s prior written consent. Tenant shall not use more than its proportionate share of telephone lines and other telecommunication facilities available to service the Building. 

16. Tenant shall not operate or permit to be operated a coin or token operated vending machine or similar device (including, without
limitation, telephones, lockers, toilets, scales, amusement devices and machines for sale of beverages, foods, candy, cigarettes and other goods), except for machines for the exclusive use of Tenant’s employees and invitees. 

17. Bicycles and other vehicles are not permitted inside the Building or on the walkways outside the Building, except in areas designated by
Landlord. 
 18. Landlord may from time to time adopt systems and procedures for the security and safety of the Building and Property, their
occupants, entry, use and contents. Tenant, its agents, employees, contractors, guests and invitees shall comply with Landlord’s systems and procedures. 

19. Landlord shall have the right to prohibit the use of the name of the Building or any other publicity by Tenant that in Landlord’s
sole opinion may impair the reputation of the Building or its desirability. Upon written notice from Landlord, Tenant shall refrain from and discontinue such publicity immediately. 

20. Neither Tenant nor its agents, employees, contractors, guests or invitees shall smoke or permit smoking in the Common Areas, unless a
portion of the Common Areas have been declared a designated smoking area by Landlord, nor shall the above parties allow smoke from the Premises to emanate into the Common Areas or any other part of the Building. Landlord shall have the right to
designate the Building (including the Premises) as a non-smoking building. 
 21. Landlord shall have the right to designate and approve
standard window coverings for the Premises and to establish rules to assure that the Building presents a uniform exterior appearance. Tenant shall ensure, to the extent reasonably practicable, that window coverings are closed on windows in the
Premises while they are exposed to the direct rays of the sun. 

  
 E-3 








 22. Deliveries to and from the Premises shall be made only at the times in the areas and through
the entrances and exits reasonably designated by Landlord. Tenant shall not make deliveries to or from the Premises in a manner that might interfere with the use by any other tenant of its premises or of the Common Areas, any pedestrian use, or any
use which is inconsistent with good business practice. 
 23. The work of cleaning personnel shall not be hindered by Tenant after 5:30
P.M., and cleaning work may be done at any time when the offices are vacant. Windows, doors and fixtures may be cleaned at any time. Tenant shall provide adequate waste and rubbish receptacles to prevent unreasonable
hardship to the cleaning service. 

  
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 EXHIBIT F 

ADDITIONAL PROVISIONS 

This Exhibit is attached to and made a part of the Office Lease Agreement (the “Lease”) by and between BRE/COH GA LLC, a
Delaware limited liability company (“Landlord”), and CLEARSIDE BIOMEDICAL, INC., a Delaware corporation (“Tenant”), for space in the Building located at 900 North Point Parkway, Alpharetta, Georgia 30005.
Capitalized terms used but not defined herein shall have the meanings given in the Lease. 
  

	1.	Parking. 

  

	 	1.01.	During the Term, Tenant agrees to lease from Landlord and Landlord agrees to lease to Tenant a total of 67 unreserved parking spaces (collectively, the “Spaces”) on a non-exclusive first come, first
served basis, for the use of Tenant and its employees, in the parking facility owned by Landlord that serves the Building (the “Parking Facility”), and if the Parking Facility includes a garage, then such Spaces may be in, or on the
roof of, such garage. No deductions or allowances shall be made for days when Tenant or any of its employees does not utilize the Parking Facility or for Tenant utilizing less than all of the Spaces. Tenant shall not have the right to lease or
otherwise use more than the number of unreserved Spaces set forth above. 

  

	 	1.02.	During the Term the Spaces shall be free of charge. 

  

	 	1.03.	Except for particular spaces and areas designated by Landlord for reserved parking, all parking in the Parking Facility shall be on an unreserved, first-come, first-served basis. Landlord shall not provide any other
tenant in the Building with reserved parking unless Landlord also provides a proportionate amount of reserved parking spaces to Tenant, provided, however, that in no event shall Tenant be entitled to receive more than a total of 4 reserved parking
spaces pursuant to this provision. 

  

	 	1.04.	Landlord shall not be responsible for money, jewelry, automobiles or other personal property lost in or stolen from the Parking Facility regardless of whether such loss or theft occurs when the Parking Facility is
locked or otherwise secured. Except as caused by the negligence or willful misconduct of Landlord and without limiting the terms of the preceding sentence, Landlord shall not be liable for any loss, injury or damage to persons using the Parking
Facility or automobiles or other property therein, it being agreed that, to the fullest extent permitted by law, the use of the Spaces shall be at the sole risk of Tenant and its employees. 


 

	 	1.05.	 Landlord shall have the right from time to time to designate the location of the Spaces and to promulgate
reasonable rules and regulations regarding the Parking Facility, the Spaces and the use thereof, including, but not limited to, rules and regulations controlling the flow of traffic to and from various parking areas, the angle and direction of
parking and the like. Tenant shall comply with and cause its employees to comply with all such rules and regulations as well as 



  
 F-1 









	 	
all reasonable additions and amendments thereto. Such rules and regulations shall be generally applicable, and generally applied in the same manner, to all parties parking in the Parking
Facility. 

  

	 	1.06.	Tenant shall not store or permit its employees to store any automobiles in the Parking Facility without the prior written consent of Landlord. Except for emergency repairs, Tenant and its employees shall not perform any
work on any automobiles while located in the Parking Facility or on the Property. If it is necessary for Tenant or its employees to leave an automobile in the Parking Facility overnight, Tenant shall provide Landlord with prior notice thereof
designating the license plate number and model of such automobile. 

  

	 	1.07.	Landlord shall have the right to temporarily close the Parking Facility or certain areas therein in order to perform necessary repairs, maintenance and improvements to the Parking Facility. 


 

	 	1.08.	Tenant shall not assign or sublease any of the Spaces without the consent of Landlord. Landlord shall have the right to terminate this Parking Agreement with respect to any Spaces that Tenant desires to sublet or
assign. 

  

	 	1.09.	Landlord may elect to provide parking cards or keys to control access to the Parking Facility. In such event, Landlord shall provide Tenant with one card or key for each Space that Tenant is leasing hereunder, provided
that Landlord shall have the right to require Tenant or its employees to place a deposit on such access cards or keys and to pay a fee for any lost or damaged cards or keys. 


 

	 	1.10.	Landlord hereby reserves the right to enter into a management agreement or lease with an entity for the Parking Facility (“Parking Facility Operator”). In such event, Tenant, upon request of Landlord,
shall enter into a parking agreement with the Parking Facility Operator, provided same does not impose additional liability or obligations on Tenant and does not restrict any of the rights granted to Tenant under this Section 1, and Landlord
shall have no liability for claims arising through acts or omissions of the Parking Facility Operator unless caused by Landlord’s negligence or willful misconduct. It is understood and agreed that the identity of the Parking Facility Operator
may change from time to time during the Term. In connection therewith, any parking lease or agreement entered into between Tenant and a Parking Facility Operator shall be freely assignable by such Parking Facility Operator or any successors thereto.


  

	2.	Extension Option. 

  

	 	2.01.	Grant of Option; Conditions. Tenant shall have the right to extend the Term (the “Extension Option”) for one additional period of 5 years commencing on the day following the Termination Date of
the initial Term and ending on the 5th anniversary of the Termination Date (the “Extension Term”), if: 


 

	 	a.	Landlord receives irrevocable and unconditional written notice of exercise (“Extension Notice”) not less than 9 full calendar months prior to the expiration of the initial Term and not more than 12 full
calendar months prior to the expiration of the initial Term; and 


  
 F-2 









	 	b.	Tenant is not in Default under the Lease beyond any applicable cure periods at the time that Tenant delivers its Extension Notice; and 


 

	 	c.	No part of the Premises is sublet (other than pursuant to a Business Transfer, as defined in Section 11.04 of the Lease) at the time that Tenant delivers its Extension Notice; and 


 

	 	d.	The Lease has not been assigned (other than pursuant to a Business Transfer, as defined in Section 11.04 of the Lease) prior to the date that Tenant delivers its Extension Notice. 


 

	 	2.02.	Terms Applicable to Premises During Extension Term. 

  

	 	a.	The initial Base Rent rate per rentable square foot for the Premises during the Extension Term shall equal the Prevailing Market (hereinafter defined) rate per rentable square foot for the Premises. Base Rent during the
Extension Term shall increase, if at all, in accordance with the increases assumed in the determination of the Prevailing Market rate. Base Rent attributable to the Premises shall be payable in monthly installments in accordance with the terms and
conditions of the Lease. 

  

	 	b.	Tenant shall pay Additional Rent (i.e. Taxes and Expenses) for the Premises during the Extension Term in accordance with the Lease, and the manner and method in which Tenant reimburses Landlord for Tenant’s share
of Taxes and Expenses and the Base Year applicable to such matter, shall be some of the factors considered in determining the Prevailing Market rate for the Extension Term. 


 

	 	2.03.	Definition of Prevailing Market. For purposes hereof, “Prevailing Market” shall mean the arm’s length fair market annual rental rate per rentable square foot under renewal leases and
amendments entered into on or about the date on which the Prevailing Market is being determined hereunder for space comparable to the Premises in the Building and office buildings comparable to the Building in the Alpharetta, Georgia area. The
determination of Prevailing Market shall take into account any material economic differences between the terms of this Lease and any comparison lease, such as rent abatements, construction costs and other concessions, the term for such lease, and
the manner, if any, in which the landlord under any such lease is reimbursed for operating expenses and taxes. Notwithstanding the foregoing, space leased under any of the following circumstances shall not be considered to be comparable for purposes
hereof: (i) the lease term is for less than 4 years or more than 7 years, (ii) the space is encumbered by the option rights of another tenant, or (iii) the space has a lack of windows and/or an awkward or unusual shape or
configuration. The foregoing is not intended to be an exclusive list of space that will not be considered to be comparable. 


  
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	 	2.04.	 Effect of Failure to Give Notice; Arbitration Procedure. Tenant shall exercise the Extension Option by
giving the Landlord the Extension Notice. If Tenant fails to give the Extension Notice to Landlord within the time period described above, then the Extension Option shall be null and void and of no further force or effect. Within 30 days of
receiving Tenant’s Extension Notice, Landlord shall give Tenant notice of Landlord’s determination of the Prevailing Market rate for the Extension Term (the “Landlord’s Determination Notice”). If Tenant disagrees with
Landlord’s determination of the Prevailing Market rate, Landlord and Tenant shall attempt to agree on the Prevailing Market rate. If the parties do not so agree on the Prevailing Market rate within 30 days of the date of Landlord’s
Determination Notice, Landlord and Tenant shall submit the determination of Prevailing Market rate to binding arbitration unless the parties otherwise mutually agree in their respective sole discretion. In such event, Landlord and Tenant shall
attempt to agree on an arbitrator within 10 days after the expiration of such 30 day period. If they fail, after good faith efforts, to agree on an arbitrator within such 10 day period, Landlord and Tenant shall each appoint a reputable commercial
leasing broker as arbitrator, each of whom shall have at least 10 years’ active and current experience in the commercial real estate industry and the Alpharetta, Georgia or North Fulton County leasing market with working knowledge of
current rental rates and leasing practices related to buildings similar to the Building. Such an appointment shall be signified in writing by each party to the other. If either party shall fail to appoint an arbitrator within a period of 10 days
after written notice from the other party to make such appointment, the sole arbitrator appointed shall make the determination of the Prevailing Market rate in the same manner provided below as though it were the third arbitrator. If both parties
appoint an arbitrator, the arbitrators so appointed shall appoint a third arbitrator, who is a reputable commercial leasing broker and has at least 10 years’ active and current experience in the commercial real estate industry and in the
Alpharetta, Georgia or North Fulton County leasing market with working knowledge of current rental rates and leasing practices related to buildings similar to the Building, within 10 days after the appointment of the second arbitrator. Each of
Landlord and Tenant shall furnish each of the three arbitrators with a copy of their respective final determination of the Prevailing Market rate. The third arbitrator shall proceed with all reasonable dispatch to determine whether Landlord’s
final determination of Prevailing Market rate or Tenant’s final determination of Prevailing Market rate, most closely reflects the Prevailing Market rate and in no event shall the arbitrator have the right (i) to average the final
determination of Prevailing Market rate of Landlord and Tenant or (ii) to choose another rate. The decision of such third arbitrator shall in any event be rendered within 30 days after his/her appointment, or within such other period as the
parties shall agree, and such decision shall be in writing and in duplicate, one counterpart thereof to be delivered to each of the parties. The arbitration shall be conducted in accordance with the rules of the American Arbitration Association (or
its successor) and applicable Law and this Section, which shall govern to the extent of any conflict between this Section and the rules of the American Arbitration Association, and the decision of the third arbitrator shall be reviewable only to the
extent provided by the rules of the American Arbitration Association and shall otherwise be binding, final and conclusive on the parties. Each party shall pay the fees of the arbitrator it chose and the fees




  
 F-4 









	 	
of its counsel and the losing party shall pay for the fees of the third arbitrator and the reasonable and necessary expenses incident to the proceedings; provided however, if a party fails to
appoint an arbitrator, the fees of the sole arbitrator shall be split between the two parties equally. 

  

	 	2.05.	Extension Amendment. If Tenant is entitled to and validly exercises its Extension Option, Landlord shall prepare an amendment (the “Extension Amendment”) to reflect changes in the Base Rent,
Term, Termination Date and other appropriate terms. The Extension Amendment shall be (i) sent to Tenant within a reasonable time after determination of the Prevailing Market rate, and (ii) executed by Tenant and returned to Landlord within
30 days after the Extension Amendment is delivered to Tenant by Landlord. Notwithstanding the foregoing, an otherwise valid exercise of the Extension Option shall be fully effective whether or not the Extension Amendment is executed.


  

	 	2.06.	Subordination. Notwithstanding anything herein to the contrary, Tenant’s Extension Option is subject and subordinate to the expansion rights (whether such rights are designated as a right of first offer,
right of first refusal, expansion option, or otherwise) of Kaplan, Inc., or any successor or assignee thereto. 

  

	 	2.07.	Time of the Essence. Time is of the essence with respect to all of the time periods set forth in this Section 2. 

  

	 	2.08.	Personal to Tenant. Notwithstanding anything herein to the contrary, Tenant’s Extension Option is personal to Tenant and in no event shall such Extension Option be assignable (other than pursuant to a
Business Transfer, as defined in Section 11.04 of the Lease). 

  

	3.	Right of First Refusal. 

  

	 	3.01.	Grant of Option; Conditions. Tenant shall have the one time right of first refusal (the “Right of First Refusal”) with respect to the approximately 910 rentable square feet of space on the
2nd floor of the Building shown on the demising plan attached hereto as Exhibit A-2 (the “Refusal Space”). Tenant’s Right of First Refusal shall be exercised as
follows: when Landlord has a prospective tenant, other than the existing tenant in the Refusal Space, (the “Prospect”) interested in leasing the Refusal Space, Landlord shall advise Tenant (the “Advice”) of the
financial terms and other material terms under which Landlord is prepared to lease the Refusal Space to such Prospect and Tenant may lease the Refusal Space, under such terms, by providing Landlord with written notice of exercise (the
“Notice of Exercise”) within 5 days after the date of the Advice, which Notice of Exercise shall include a representation and warranty from Tenant to Landlord that the Refusal Space is intended for the exclusive use of Tenant during
the Term. Notwithstanding the foregoing, Tenant shall have no such Right of First Refusal and Landlord need not provide Tenant with an Advice if: 

  

	 	a.	Tenant is in Default under the Lease beyond any applicable cure periods at the time that Landlord would otherwise deliver the Advice; or 


  
 F-5 









	 	b.	the Premises, or any portion thereof, is sublet (other than pursuant to a Business Transfer, as defined in Section 11.04 of the Lease) at the time Landlord would otherwise deliver the Advice; or 


 

	 	c.	the Lease has been assigned (other than pursuant to a Business Transfer, as defined in Section 11.04 of the Lease) prior to the date Landlord would otherwise deliver the Advice; or 


 

	 	d.	Tenant is not occupying the Premises on the date Landlord would otherwise deliver the Advice; or 

  

	 	e.	the Refusal Space is not intended for the exclusive use of Tenant during the Term; or 

  

	 	f.	the existing tenant or occupant in the Refusal Space is interested in extending or renewing its lease for the Refusal Space or entering into a new lease for such Refusal Space or any other person or entity having any
pre-existing rights in the Refusal Space is interested in entering into a new lease for the Refusal Space. 

  

	 	3.02.	Terms for Refusal Space. 

  

	 	a.	The term for the Refusal Space shall commence upon the commencement date stated in the Advice and thereupon such Refusal Space shall be considered a part of the Premises, provided that all of the terms stated in the
Advice, including the termination date set forth in the Advice, shall govern Tenant’s leasing of the Refusal Space and only to the extent that they do not conflict with the Advice, the terms and conditions of the Lease shall apply to the
Refusal Space. Tenant shall pay Base Rent and Additional Rent for the Refusal Space in accordance with the terms and conditions of the Advice. 

  

	 	b.	The Refusal Space (including improvements and personalty, if any) shall be accepted by Tenant in its as is condition and as-built configuration existing on the earlier of the date Tenant takes possession of the Refusal
Space or the date the term for such Refusal Space commences, unless the Advice specifies work to be performed by Landlord in the Refusal Space, in which case Landlord shall perform such work in the Refusal Space. If Landlord is delayed delivering
possession of the Refusal Space due to the holdover or unlawful possession of such space by any party, Landlord shall use reasonable efforts to obtain possession of the space, and the commencement of the term for the Refusal Space shall be postponed
until the date Landlord delivers possession of the Refusal Space to Tenant free from occupancy by any party. 

  

	 	3.03.	 Termination of Right of First Refusal. The rights of Tenant hereunder with respect to the Refusal Space
shall terminate on the earlier to occur of (i) the last day of 60th full calendar month of the Term; (ii) Tenant’s failure to exercise its Right of First Refusal within the 5 day
period provided in Section 3.01 above; and 



  
 F-6 









	 	
(iii) the date Landlord would have provided Tenant an Advice if Tenant had not been in violation of one or more of the conditions set forth in Section 3.01 above. In addition, if
Landlord provides Tenant with an Advice for any portion of the Refusal Space that contains expansion rights (whether such rights are described as an expansion option, right of first refusal, right of first offer or otherwise) with respect to any
other portion of the Refusal Space (such other portion of the Refusal Space subject to such expansion rights is referred to herein as the “Encumbered Refusal Space”) and Tenant does not exercise its Right of First Refusal to lease
the Refusal Space described in the Advice, Tenant’s Right of First Refusal with respect to the Encumbered Refusal Space shall be subject and subordinate to all such expansion rights contained in the Advice. 


 

	 	3.04.	Refusal Space Amendment. If Tenant exercises its Right of First Refusal, Landlord shall prepare an amendment (the “Refusal Space Amendment”) adding the Refusal Space to the Premises on the terms
set forth in the Advice and reflecting the changes in the Base Rent, Rentable Square Footage of the Premises, Tenant’s Pro Rata Share and other appropriate terms. A copy of the Refusal Space Amendment shall be sent to Tenant within a reasonable
time after Landlord’s receipt of the Notice of Exercise executed by Tenant, and Tenant shall execute and return the Refusal Space Amendment to Landlord within 15 days thereafter, but an otherwise valid exercise of the Right of First
Refusal shall be fully effective whether or not the Refusal Space Amendment is executed. 

  

	 	3.05.	Subordination. Notwithstanding anything herein to the contrary, Tenant’s Right of First Refusal is subject and subordinate to (i) the renewal or extension rights of any tenant leasing all or any portion
of the Refusal Space, and (ii) the expansion rights (whether such rights are designated as a right of first offer, right of first refusal, expansion option or otherwise) of Kaplan, Inc., or any successor or assignee thereto. 


 

	 	3.06.	Time of the Essence. Time is of the essence with respect to all time periods set forth in this Section 3. 

  

	 	3.07.	Personal to Tenant. Notwithstanding anything herein to the contrary, Tenant’s Right of First Refusal is personal to Tenant and in no event shall such Right of First Refusal be assignable or exercisable by
any party other than the original named Tenant (except in connection with a Business Transfer, as defined in Section 11.04 of the Lease). 

  

	4.	Monument Signage. 

  

	 	4.01.	 During the initial Term and any extension thereof and provided that Tenant is not in Default under the Lease
beyond any applicable notice and cure period and further provided that throughout the Term of the Lease (and any extension thereof) Tenant leases and occupies at least 18,500 rentable square feet in the Building, Tenant, at Tenant’s sole cost,
but subject to governmental approval, shall have the right to place its name on the Building monument sign located at the entrance to the Building (the “Monument Sign”). The design, size and color of the signage with Tenant’s
name to be included on the Monument Sign, and the 



  
 F-7 









	 	
manner in which such signage is attached to the Monument Sign, shall be subject to the reasonable approval of Landlord, such approval not to be unreasonably withheld, conditioned or delayed and
the approval of all applicable governmental authorities, and Landlord shall have the right to require that all names on the Monument Sign be of the same size and style. Tenant, at its cost, shall be responsible for the maintenance, repair or
replacement of Tenant’s signage on the Monument Sign, which shall be maintained in a manner reasonably satisfactory to Landlord. Tenant’s right to place its name on the Monument Sign, and the location of Tenant’s name on the Monument
Sign, shall be subject to the existing rights of existing tenants in the Building, and the location of Tenant’s name on the Monument Sign shall be further subject to Landlord’s reasonable approval. Although the Monument Sign will be
maintained by Landlord, Tenant shall pay its proportionate share of the cost of any maintenance and repair associated with the Monument Sign. 

  

	 	4.02.	Upon expiration or earlier termination of the Lease or Tenant’s right to possession of the Premises, or if Tenant is in Default under the Lease beyond any applicable notice and cure period, or if Tenant leases or
occupies less than 18,500 rentable square feet in the Building, then Tenant shall have no further right to place its name on the Monument Sign, and Tenant, at its cost within 30 days after request of Landlord, shall remove Tenant’s signage from
the Monument Sign and restore the affected portion of the Monument Sign to the condition it was in prior to installation of Tenant’s signage thereon, ordinary wear and tear excepted. If Tenant does not perform such work within such 30 day
period, then Landlord may do so, at Tenant’s cost, and Tenant shall reimburse Landlord, as Additional Rent, for the cost of such work within 30 days after request therefor. 


 

	 	4.03.	Notwithstanding anything herein to the contrary, Tenant’s rights with respect to the Monument Sign are personal to Tenant and in no event shall the rights set forth in this Section 4 be assignable.


  

	5.	Letter of Credit. 

  

	 	5.01.	 General Provisions. Concurrently with Tenant’s execution of this Lease, Tenant shall deliver to
Landlord, as collateral for the full performance by Tenant of all of its obligations under this Lease and for all losses and damages Landlord may suffer as a result of Tenant’s failure to comply with one or more provisions of this Lease,
a standby, unconditional, irrevocable, transferable letter of credit (the “Letter of Credit”) substantially in the form of Exhibit G hereto (or such other form as may be reasonably acceptable to Landlord) and
containing the terms required herein, in the face amount of $360,000.00 (the “Letter of Credit Amount”), naming Landlord as beneficiary, issued (or confirmed) by a financial institution acceptable to Landlord in Landlord’s sole
discretion, permitting multiple and partial draws thereon, and otherwise in form acceptable to Landlord in its sole discretion. Tenant shall cause the Letter of Credit to be continuously maintained in effect (whether through replacement, renewal or
extension) in the Letter of Credit Amount through the date (the “Final LC Expiration Date”) that is 60 days after the scheduled expiration date of the Term or any renewal Term. If




  
 F-8 









	 	
the Letter of Credit held by Landlord expires earlier than the Final LC Expiration Date (whether by reason of a stated expiration date or a notice of termination or non-renewal given by the
issuing bank), Tenant shall deliver a new Letter of Credit or certificate of renewal or extension (a “Renewal or Replacement LC”) to Landlord not later than 60 days prior to the expiration date of the Letter of Credit then held by
Landlord. Any Renewal or Replacement LC shall comply with all of the provisions of this Section 5, shall be irrevocable, transferable and shall remain in effect (or be automatically renewable) through the Final LC Expiration Date upon the same
terms as the expiring Letter of Credit or such other terms as may be acceptable to Landlord in its sole discretion. Notwithstanding the foregoing, if at any time during the Term Landlord reasonably determines that the financial condition of the
issuing bank is such that Landlord’s ability to draw upon the Letter of Credit is, or in the future may be, impaired, restricted, refused or otherwise affected, then Tenant shall, within 10 business days of Landlord’s written request to
Tenant, obtain a renewal or replacement Letter of Credit in form acceptable to Landlord in substitution of the then current Letter of Credit from an issuing bank acceptable to Landlord in Landlord’s reasonable discretion. 


 

	 	5.02.	Drawings under Letter of Credit. Upon Tenant’s failure to comply with one or more provisions of this Lease, or as otherwise specifically agreed by Landlord and Tenant pursuant to this Lease or any amendment
hereof, Landlord may, without prejudice to any other remedy provided in this Lease or by Law, draw on the Letter of Credit and use all or part of the proceeds to (a) satisfy any amounts due to Landlord from Tenant, and (b) satisfy any
other damage, injury, expense or liability caused by Tenant’s failure to so comply. In addition, if Tenant fails to furnish a Renewal or Replacement LC complying with all of the provisions of this Section 5 at least 60 days prior to the
stated expiration date of the Letter of Credit then held by Landlord, Landlord may draw upon such Letter of Credit and hold the proceeds thereof (and such proceeds need not be segregated) in accordance with the terms of this Section 5 (the
“LC Proceeds Account”). 

  

	 	5.03.	 Use of Proceeds by Landlord. The proceeds of the Letter of Credit shall constitute Landlord’s sole
and separate property (and not Tenant’s property or the property of Tenant’s bankruptcy estate) and Landlord may immediately upon any draw (and without notice to Tenant) apply or offset the proceeds of the Letter of Credit:
(a) against any Rent payable by Tenant under this Lease that is not paid when due; (b) against all losses and damages that Landlord has suffered or that Landlord reasonably estimates that it may suffer as a result of Tenant’s failure
to comply with one or more provisions of this Lease; (c) against any costs incurred by Landlord in connection with the Lease (including attorneys’ fees); and (d) against any other amount that Landlord may spend or become obligated to
spend by reason of Tenant’s Default. Provided Tenant has performed all of its obligations under this Lease, Landlord agrees to pay to Tenant within 45 days after the Final LC Expiration Date the amount of any proceeds of the Letter of Credit
received by Landlord and not applied as allowed above; provided, that if prior to the Final LC Expiration Date a voluntary petition is filed by Tenant or any Guarantor, or an involuntary petition is filed against Tenant or any Guarantor by any of
Tenant’s or Guarantor’s creditors, under the Federal Bankruptcy Code, 



  
 F-9 









	 	
then Landlord shall not be obligated to make such payment in the amount of the unused Letter of Credit proceeds until either all preference issues relating to payments under this Lease have been
resolved in such bankruptcy or reorganization case or such bankruptcy or reorganization case has been dismissed, in each case pursuant to a final court order not subject to appeal or any stay pending appeal. 


 

	 	5.04.	Additional Covenants of Tenant. If, as result of any application or use by Landlord of all or any part of the Letter of Credit, the amount of the Letter of Credit shall be less than the Letter of Credit Amount,
Tenant shall, within 5 days thereafter, provide Landlord with additional letter(s) of credit in an amount equal to the deficiency (or a replacement letter of credit in the total Letter of Credit Amount), and any such additional (or replacement)
letter of credit shall comply with all of the provisions of this Section 5, and if Tenant fails to comply with the foregoing, notwithstanding anything to the contrary contained in this Lease, the same shall constitute an incurable Default by
Tenant. Tenant further covenants and warrants that it will neither assign nor encumber the Letter of Credit or any part thereof and that neither Landlord nor its successors or assigns will be bound by any such assignment, encumbrance, attempted
assignment or attempted encumbrance. 

  

	 	5.05.	Nature of Letter of Credit. Landlord and Tenant (a) acknowledge and agree that in no event or circumstance shall the Letter of Credit or any renewal thereof or substitute therefor or any proceeds thereof
(including the LC Proceeds Account) be deemed to be or treated as a “security deposit” under any Law applicable to security deposits in the commercial context (“Security Deposit Laws”), (b) acknowledge and agree that
the Letter of Credit (including any renewal thereof or substitute therefor or any proceeds thereof) is not intended to serve as a security deposit, and the Security Deposit Laws shall have no applicability or relevancy thereto, and (c) waive
any and all rights, duties and obligations either party may now or, in the future, will have relating to or arising from the Security Deposit Laws. 

  

	 	5.06.	 Reduction in Letter of Credit Amount. Provided that, during the 12 month period immediately preceding
the effective date of any reduction of the Letter of Credit, Tenant has timely paid all Rent and no Default has occurred under this Lease (the “LC Reduction Conditions”), Tenant may reduce the Letter of Credit Amount so that the
reduced Letter of Credit Amounts will be as follows: (a) $260,000.00 effective as of the first day of the 49th full calendar month of the Term; and (b) $160,000.00 effective as of the
first day of the 61st full calendar month of the Term. If Tenant is not entitled to reduce the Letter of Credit Amount as of a particular reduction effective date due to Tenant’s failure to
satisfy the LC Reduction Conditions described above, then any subsequent reduction(s) Tenant is entitled to hereunder shall be reduced by the amount of the reduction Tenant would have been entitled to had Tenant satisfied the LC Reduction Conditions
necessary for such earlier reduction. Notwithstanding anything to the contrary contained herein, if Tenant has been in Default under this Lease at any time prior to the effective date of any reduction of the Letter of Credit Amount and Tenant has
failed to cure such Default within any applicable cure period, then Tenant 



  
 F-10 









	 	
shall have no further right to reduce the Letter of Credit Amount as described herein. Any reduction in the Letter of Credit Amount shall be accomplished by Tenant providing Landlord with a
substitute letter of credit in the reduced amount or an amendment to the existing Letter of Credit reflecting the reduced amount. 

  

	6.	Conference Room. 

  

	 	6.01.	During the Term, subject to the provisions of this Section 6, Tenant shall have the non-exclusive right to utilize the Conference Room (as defined in Section 2 of Exhibit C (Work Letter) of this
Lease) at the Building, for a total of 10 hours during each calendar month during the Term at no charge to Tenant (except as herein provided). The Conference Room is intended for the general use of all tenants at the Building and the building
located at 800 North Point Parkway, Alpharetta, Georgia 30005, and commonly known as 800 North Point (“800 North Point”). The Conference Room availability shall be on a “first come, first served” basis and shall be subject
to closures due to Force Majeure or temporary closure due to the performance of repairs, replacements or other alterations Landlord desires or is required to perform. Landlord may relocate the Conference Room within the Building or to 800 North
Point. The fee for any use of the Conference Room which exceeds 10 hours in any calendar month shall be at the then current rate charged for use of the Conference Room. 


 

	 	6.02.	Tenant’s use of the Conference Room shall be subject to the following: (a) scheduling availability of the Conference Room; (b) the reasonable operating procedures, rules and regulations promulgated by
Landlord from time to time and distributed to Tenant and other tenants and occupants of the Building and 800 North Point; (c) Tenant is not in Default; (d) Tenant’s payment of Landlord’s then current charge for the Conference
Room (subject to the terms of Section 6.01 above); (e) Tenant’s payment of all costs associated with services and amenities used in connection with the Conference Room, including, without limitation, additional audio-visual equipment,
and food service as may be requested by Tenant and Landlord’s clean up fee; and (f) Tenant’s compliance with Landlord’s sign-up and reservation procedures. Notwithstanding the foregoing, the parties agree that Tenant will provide
and confirm the 10 hours during each calendar month during the Term that Tenant will need the Conference Room at least 30 days in advance. 

  

	 	6.03.	Landlord reserves the right to discontinue providing the Conference Room for a period of up to 60 days in order to build out new Conference Room space in the Building or at 800 North Point if Landlord elects to convert
all or any part of the Conference Room to space offered for lease to existing or future tenants, or if Landlord otherwise desires to recapture all or a portion of such space for other purposes. In such event, Landlord may discontinue providing the
Conference Room for such 60-day period upon first giving not less than 30 days’ prior notice to Tenant, and Landlord may also discontinue providing the Conference Room in the event of Force Majeure or temporary closures due to the performance
of repairs, replacements or other alterations Landlord desires or is required to perform. No expansion, contraction, or modification of the Conference Room, and no termination of Tenant’s rights to the Conference Room as specifically provided
herein, shall entitle Tenant to an abatement or reduction in Rent or constitute a constructive eviction or an event of default by Landlord under this Lease. 


  
 F-11 









	 	6.04.	Landlord and Tenant acknowledge that the use of the Conference Room by Tenant and its employees and invitees shall be at their sole risk and that the terms and provisions of Section 13 (Indemnity and Waiver of
Claims) of this Lease shall apply to Tenant’s use of the Conference Room. 

  

	 	6.05.	The rights granted herein shall be personal to Tenant and shall not apply to any sublessee, transferee or to any successor in interest (other than an assignment pursuant to a Business Transfer). 


 

	7.	Deferred Space. 

  

	 	7.01.	Tenant hereby leases from Landlord and Landlord leases to Tenant approximately 963 total rentable square feet on the 2nd floor as shown on
Exhibit A-3 and labeled “Deferred Space”. The Term with respect to the Deferred Space shall commence effective as of the Deferred Space Commencement Date (hereinafter defined). 


 

	 	7.02.	The term for the Deferred Space shall commence on the date (the “Deferred Space Commencement Date”) which is the earlier to occur of (i) the date identified in a written early commencement letter
from Tenant to Landlord indicating the date Tenant would like the Deferred Space Commencement Date to be, and (ii) the later to occur of (a) the first day of the 18th full calendar month
following the Commencement Date, and (b) the date Tenant begins its business operations in the Deferred Space. The Deferred Space shall be considered part of the Premises subject to all the terms and conditions of this Lease, except that no
allowances, credits, abatements or other concessions (if any) set forth in this Lease for the Premises or any other expansions shall apply to the Deferred Space, except as expressly set forth below. 


 

	 	7.03.	The Deferred Space shall be leased by Tenant pursuant to all the terms and conditions of the Lease, except that the financial terms and conditions for the Deferred Space shall be as follows: 


 

	 	a.	The Base Rent rate per square foot for the Deferred Space shall be the same as the Base Rent rate per square foot for the Premises on the Deferred Space Commencement Date. The Base Rent rate per square foot for the
Deferred Space shall adjust at the times and in the amounts specified in the Lease with respect to the remainder of the original Premises. However, Tenant shall not be entitled to abatement of Rent with respect to the Deferred Space.


  

	 	b.	 Tenant shall pay Tenant’s Pro Rata Share of Expenses and Taxes for the Deferred Space on the same terms and
conditions set forth in the Lease, provided that Tenant’s Pro Rata Share shall increase appropriately to account for the addition of the Deferred Space. 



  
 F-12 









	8.	Initial Suite Signage and Building Directory. Notwithstanding anything to the contrary contained in Section 3 and Section 4 of Exhibit E (Building Rules and Regulations) of the Lease,
Landlord, at Landlord’s cost and expense, shall install, for the Tenant as initially named herein, using the standard graphics for the Building, initial Building standard tenant identification and suite numbers at the entrance to the initial
Premises and on the Building directory in the main Building lobby. Thereafter, any additional tenant identification shall be (i) subject to Landlord’s prior review and approval thereof, and (ii) installed by Landlord, at Tenant’s
cost and expense, using the standard graphics for the Building. 

  

	9.	Environmental Substances.  

 “Environmental
Law(s)” means all statutes, Laws, rules, regulations, codes, ordinances, standards, guidelines, authorizations and orders of federal, state and local public authorities pertaining to any of the Environmental Substances or to environmental
compliance, contamination, cleanup or disclosures of any release or threat of release to the environment, of any hazardous or toxic substances, wastes or materials, any pollutants or contaminants which are included under or regulated by any
municipal, county, state or federal statutes, Laws, rules, regulations, codes, ordinances, standards, guidelines, authorizations or orders, including, without limitation, the Toxic Substances Control Act, 15 U.S.C. § 2601, et seq.; the
Clean Water Act, 33 U.S.C. § 1251, et seq.; the Clean Air Act, 42 U.S.C. § 7401, et seq.; the Safe Drinking Water Act, 42 U.S.C. § 300f-300j, et seq.; the Federal Water Pollution Control Act, 33 U.S.C. §
1321, et seq.; the Solid Waste Disposal Act, 42 U.S.C. § 6901, et seq.; the Comprehensive Environmental Response, Compensation and Liability Act of 1980, 42 U.S.C. Section 9601 et seq.; the Federal Resource
Conservation and Recovery Act, 42 U.S.C. Section 6901 et seq.; the Superfund Amendments and Reauthorization Act of 1986, Public Law No. 99-499 (signed into law October 17, 1986), as any of the same are from time to time
amended, and the rules and regulations promulgated thereunder, and any judicial or administrative interpretation thereof, including any judicial or administrative orders or judgments, and all other federal, state and local statutes, Laws, rules,
regulations, codes, ordinances, standards, guidelines, authorizations and orders regulating the generation, storage, containment or disposal of any Environmental Substances, including but not limited to those relating to lead paint, radon gas,
asbestos, storage and disposal of oil and hazardous wastes, substances and materials, and underground and above-ground oil storage tanks; and any amendments, modifications or supplements of any of the foregoing. 

“Environmental Substances” means, but shall not be limited to, any hazardous substances, hazardous waste, environmental
substances, oil, petroleum products and any waste or substance, which because of its quantitative concentration, chemical, biological, radioactive, flammable, explosive, infectious or other characteristics, constitutes or may reasonably be expected
to constitute or contribute to a danger or hazard to public health, safety or welfare or to the environment, including without limitation any asbestos (whether or not friable) and any asbestos-containing materials, lead paint, waste oils, solvents
and chlorinated oils, polychlorinated biphenyls (PCBs), toxic metals, etchants, pickling and plating wastes, explosives, reactive metals and compounds, pesticides, herbicides, radon gas, urea formaldehyde foam insulation and chemical, biological and
radioactive wastes, or any other similar materials which are 

  
 F-13 








 
mentioned under or regulated by any Environmental Law; and the regulations adopted under these acts, and including any other products or materials subsequently found by an authority of competent
jurisdiction to have adverse effects on the environment or the health and safety of persons. 
 Tenant shall not cause or
permit any Environmental Substances to be generated, produced, brought upon, used, stored, treated or disposed of in or about or on the Building by Tenant, its agents, employees, contractors, subtenants or invitees without (i) Landlord’s
prior written consent, and (ii) strictly complying with all applicable Environmental Laws and Laws pertaining to the transportation, storage, use or disposal of such Environmental Substances, including, if required under Environmental Laws,
obtaining proper permits. Landlord may take into account any factors or facts that Landlord reasonably believes relevant in determining whether to grant its consent. Landlord consents to Tenant’s use in the Lab Space of (i) acetone (not to
exceed 4 liters) and alcohol for cleaning (not to exceed 4 liters). From time to time at Landlord’s request, Tenant shall execute affidavits, representations and the like concerning Tenant’s best knowledge and belief regarding the presence
or absence of Environmental Substances on the Premises or the Property, and shall provide copies of all required permits for Tenant’s activities in the Premises. Furthermore, commencing on the date that Tenant first uses Environmental
Substances that require permitting and quarterly thereafter, or more often if reasonably required by Landlord’s Mortgagee, Tenant shall provide Landlord with a list detailing the types and amounts of all Environmental Substances being
generated, produced, brought upon, used, stored, treated or disposed of by or on behalf of Tenant in or about or on the Premises, Building or Property and, upon Landlord’s request, copies of any manifests or other federal, state or municipal
filings by Tenant with respect to such Environmental Substances. Tenant represents and warrants that as of the Commencement Date there will be no Environmental Substances located within the Premises which require permits. From the date Tenant begins
using any Environmental Substances for which permitting is necessary, Tenant agrees to pay the cost of any environmental inspection or assessment requested by any lender that holds a security interest in the Property or this Lease, or by any
insurance carrier, to the extent that such inspection or assessment pertains to any release, threat of release, contamination, claim of contamination, loss or damage or determination of condition (together, “Environmental
Incidents”) in the Premises other than Environmental Incidents arising prior to the date Tenant occupies the Premises for the conduct of its business or migrating to the Premises from some other part of the Building through no fault, act or
omission of Tenant. 
 If Tenant’s transportation, storage, use or disposal of Environmental Substances on the Property
results in the contamination of the soil or surface or ground water or loss or damage to person(s) or property, Tenant agrees to: (a) notify Landlord immediately of any release, threat of release, contamination, claim of contamination, loss or
damage; (b) after consultation with Landlord, clean up the release, threat of release, or contamination in full compliance with all applicable statutes, regulations and standards and (c) indemnify, defend and hold Landlord, ground
landlord, if any, and the Landlord Related Parties harmless from and against any claims, suits, causes of action, costs and fees, including attorneys’ fees and costs, arising from or connected with any such release, threat of release,
contamination, claim of contamination, loss or damage. In the event of such contamination, Tenant agrees to cooperate fully with Landlord and provide 

  
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such documents, affidavits and information as may be requested by Landlord (1) to comply with any Environmental Law or Laws, (2) to comply with the reasonable request of any lender,
purchaser or tenant, and/or (3) for any other reasonable reason deemed necessary by Landlord. Tenant shall notify Landlord promptly in the event of any spill or other release of any Environmental Substance at, in, on, under or about the
Premises which is required to be reported to a governmental authority under any Environmental Law or Laws, shall promptly forward to Landlord copies of any notices received by Tenant relating to alleged violations of any Environmental Law or Laws
and shall promptly pay when due any fine or assessment against Landlord, Tenant, or the Premises relating to any violation during the Term of any Environmental Law or Laws by Tenant, its employees, agents, independent contractors, or invitees or
with respect to the Premises or Property. If any governmental authority files a lien against the Premises due to any act or omission, intentional or unintentional, of Tenant, its agents, employees, or invitees, or for which Tenant is responsible,
resulting in the releasing, spilling, leaking, leaching, pumping, emitting, pouring, emptying or dumping of any Environmental Substance, Tenant shall, within thirty (30) days from the date that Tenant is first given notice of such lien (or
within such shorter period of time as may be specified by Landlord if such governmental authority takes steps to cause the Premises to be sold pursuant to such lien) either (A) pay the claim and remove the lien or (B) furnish a cash
deposit, bond or such other security as is satisfactory in all respects to Landlord and sufficient to discharge the lien completely. 
 The
provisions of this Section 9 survive the expiration or earlier termination of this Lease. 
  

	10.	Hazardous Medical Waste.  

 Tenant hereby agrees to furnish to Landlord upon
demand, written evidence of its safety procedures related to the identification, collection, storage and disposal of Hazardous Medical Waste (defined below), which shall be in compliance with all applicable Laws and the policies of a commercially
reasonable third party medical waste collection company. Tenant represents, warrants and covenants that in no event shall Tenant, at any time before, during or after the Term of this Lease, cause or permit any Infectious Waste (defined below) to be
generated, produced, brought upon, used, stored, treated or disposed of in or about the Building by Tenant, its agents, employees, contractors, subtenants or invitees. Tenant is responsible for the proper containment and identification of its
Hazardous Medical Waste, the disposal of the Hazardous Medical Waste and the transportation of the Hazardous Medical Waste using a properly qualified agent, all as applicable if and when Tenant is producing such Hazardous Medical Waste within the
Premises. Landlord shall have the right to reasonably designate an area within the Premises for the pick-up of Hazardous Medical Waste if and when Tenant is producing such Hazardous Medical Waste within the Premises. 

“Hazardous Medical Waste” is defined as used needles and syringes, gloves and linen, uniforms and laundry, and cleaning
equipment or materials used to clean any of the foregoing; any solid, liquid or gas that is capable of producing harmful affects on humans or the environment; material that is ignitable, corrosive, reactive or toxic; or any materials that are
classified as hazardous medical waste by Law. 

  
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“Infectious Waste” is defined as any waste that contains pathogens or is capable of producing infectious disease; material contaminated by potentially infectious materials
(taking into consideration the factors necessary for induction of disease, which include, but are not limited to, adequate dose, resistance of host, portal of entry and presence of a pathogen and virulence); material that contains pathogens with
sufficient virulence and quantity so that exposure to the waste by a susceptible host could result in an infectious disease; or wastes capable of causing disease. Including but not limited to: 

A. Cultures and stocks of agents infectious to humans, and associated biologicals (including but not limited to cultures from
medical laboratories; waste from the production of biologicals; discarded live and attenuated vaccines, and culture dishes and devices used to transfer, inoculate and mix cultures); 

B. Human pathological wastes [including but not limited to tissue, organs and body parts (except teeth and the contiguous
structures of bone and gum), and body fluids that are removed during medical procedures and specimens of body fluids and their containers]; 

C. Discarded waste blood and blood components (including but not limited to serum and plasma) and saturated material containing
free flowing blood and blood components (including but not limited to lab specimens); 
 D. Discarded sharps used in human
patient care, medical research or clinical or pharmaceutical laboratories (including but not limited to hypodermic, I.V., and other medical needles; hypodermic and I.V. syringes; Pasteur pipettes; scalpel blades; blood vials; and broken or unbroken
glassware in contact with infectious agents, including slides or cover slips); and 
 E. Discarded hypodermic, I.V. and other
medical needles, hypodermic, I.V., syringes, sharps and scalpel blades and whether used or unused (as it is often difficult to determine if they have been used). 

Tenant further agrees that: (a) Tenant’s employees and agents shall be expressly forbidden from disposing of any
Hazardous Medical Waste within the Premises or the Building in a manner which is contrary to applicable Laws or the terms of this Lease; (b) all such Hazardous Medical Waste shall be collected, stored, decontaminated and removed from the
Premises and the Building by a qualified party in compliance with all applicable Laws and guidelines (including, without limitation, the Occupational Safety and Health Act) of any local, state or federal entity having jurisdiction over this matter;
(c) needles and sharps shall be contained in disposable rigid containers which can be sealed with a tight fitting lid; and (d) Tenant and its employees and agents shall at all times employ proper procedures, including, without limitation,
the use of tags, signs or other appropriate written communication, to prevent accidental injury or illness to other tenants in the Building (including their employees, agents and invitees) resulting from Tenant’s collection, storage,
decontamination and disposal of Hazardous Medical Waste. Tenant hereby covenants and agrees that at all times during the Term, Tenant and its employees and agents shall adhere to the terms and conditions of this Section 10. Tenant agrees to
indemnify, defend and hold Landlord and the Landlord Related Parties harmless from and against any and all liabilities, obligations, 

  
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damages, penalties, claims, costs, charges or expenses, including without limitation, attorney’s fees, clean-up costs, fines or penalties arising out of or resulting from Tenant’s
violation of this Section 10. 
 The provisions of this Section 10 survive the expiration or earlier termination of
this Lease. 
  

	11.	Lab Standards.  

 Tenant shall keep and maintain the Lab Space in accordance with
all applicable Federal, State and local laws, guidelines and policies relating to the operation and maintenance of biomedical laboratory facilities (collectively, the “Lab Standards”). 

A. In no event shall Tenant bring any live animals onto the Property or any animal body parts that are not considered raw food
by the Food and Drug Administration. Any animal body parts that are considered raw food that are brought onto the Property shall be transported in accordance with such rules and regulations as Landlord shall reasonably designate. In no event shall
Tenant use or occupy the Lab Space in a manner that would be inconsistent with the character and dignity of the Building and Landlord may require Tenant to immediately cease any business, procedures, activities or other use which is causing
disturbance of, or interference with Landlord’s operation and management of the Building or the use and occupancy thereof by any tenant therein. 

B. Without limiting the limitations imposed by the Permitted Use clause, Tenant shall not use or permit the Lab Space to be
used for any purpose that would allow animal, medical or medicinal odors, fumes or noises to emanate from the Lab Space. In the event such odors, fumes or noises do emanate from the Lab Space, Tenant, at its sole cost and expense, shall be
responsible for taking whatever steps are necessary in accordance with all applicable Laws and the terms of this Lease in order to either eliminate such odors, fumes or noises or to keep such odors, fumes or noises from emanating from the Buildings
in a manner approved by Landlord. Such steps may include the installation of an exhaust system or sound proofing in accordance with plans and specifications approved by Landlord. If Landlord and Tenant are unable to reach an agreement on the course
of action Tenant will take to correct the odor or noise problem, as the case may be, within 10 days after the date Landlord first contacts Tenant to inform Tenant of the odor or noise problem, Landlord (in its reasonable discretion) shall determine
the course of action Tenant shall take to correct the odor or noise problem. Such work to correct the odor or noise problem shall be completed by Tenant within 30 days of the date a determination is made by either Landlord or Landlord and Tenant (as
applicable) as to the scope of work Tenant shall perform. 
 C. Tenant agrees to be solely responsible for the disposal of
all medical, infectious and hazardous waste (including without limitation, all needles, syringes, bloodbags, bandages and vials) and all animal bodies or parts that are generated in the Tenant’s Lab Space and to indemnify and hold Landlord
harmless from and against all liabilities, obligations, damages, penalties, claims, costs, charges and expenses which may be imposed upon, incurred by, or asserted against Landlord in connection with the generation and existence of such medical,
infectious and/or hazardous waste (including 

  
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without limitation, all needles, syringes, bloodbags, bandages and vials) and all animal bodies or parts and the removal thereof from the Lab Space. Tenant agrees to comply with all Laws,
ordinances, orders, rules, and regulations of any governmental or regulatory agency with respect to the generation, existence, removal, storage and disposal of any such medical, infectious and/or hazardous waste (including without limitation, all
needles, syringes, bloodbags, bandages and vials) and all animal bodies and parts. 
 D. Tenant agrees to contract with a
licensed and insured medical waste disposal vendor acceptable to Landlord for the lawful disposal of all medical, infectious and hazardous waste (including without limitation, all needles, syringes, blood bags, bandages and vials) and all animal
bodies and parts that are generated in Tenant’s Lab Space, and to provide a copy of such contract to Landlord. If vendors are changed, Tenant agrees to notify Landlord of such change prior to the effective date thereof and to provide the
appropriate documentation to Landlord. In no event shall any medical, infectious and/or hazardous waste be placed or stored outside of the Lab Space, it being agreed that all such materials shall be kept in the Lab Space until picked up by the
approved medical waste disposal vendor. 
 E. Tenant, at Tenant’s sole cost and expense, shall obtain and maintain
throughout the Term any licenses, permits or zoning approvals required by any governmental body for the conduct of Tenant’s business and medical uses with the Lab Space. 

F. In the event Tenant’s activities in the Project results in any unreasonable disturbance, disruption of or interference
with the business of the Project, including, but not limited to, demonstrations, pickets, boycotts and/or confrontations or disputes on or about the Project opposing or supporting Tenant’s activities (a “Use Dispute”), then
Tenant shall take all actions necessary to resolve the Use Dispute and to have the demonstrators, picketers or other individuals engaged in the Use Dispute removed from the Project in an expeditious manner. Tenant shall have no claim for damages
against Landlord or any of the Landlord Related Parties, as a result of the above actions. 
 The provisions of this Section 11 survive
the expiration or earlier termination of this Lease. 

  
 F-18 








 EXHIBIT G 

FORM OF LETTER OF CREDIT 

This Exhibit is attached to and made a part of the Office Lease Agreement (the “Lease”) by and between BRE/COH GA LLC, a
Delaware limited liability company (“Landlord”), and CLEARSIDE BIOMEDICAL, INC., a Delaware corporation (“Tenant”), for space in the Building located at 900 North Point Parkway, Alpharetta, Georgia 30005.
Capitalized terms used but not defined herein shall have the meanings given in the Lease. 
  

                       
                            

[Name of Financial Institution] 
  

	
	Irrevocable Standby Letter of Credit
	
No.                  
                       

	 Issuance
Date:                        

	 Expiration
Date:                     

	 Applicant: Clearside Biomedical, Inc.



 Beneficiary 

BRE/COH GA LLC 
 c/o Equity Office 

222 South Riverside Plaza 
 Suite 2000 

Chicago, Illinois 60606 
 Attention: Treasury Department 

Ladies/Gentlemen: 
 We hereby establish our
Irrevocable Standby Letter of Credit in your favor for the account of the above referenced Applicant in the amount of Three Hundred Sixty Thousand and NO/100 U.S. Dollars ($360,000.00) available for payment at sight by your draft drawn on us when
accompanied by the following documents: 
  

	1.	An original copy of this Irrevocable Standby Letter of Credit. 

  

	2.	Beneficiary’s dated statement purportedly signed by an authorized signatory or agent reading: “This draw in the amount of          U.S. Dollars
($        ) under your Irrevocable Standby Letter of Credit No.                     
represents funds due and owing to us pursuant to the terms of that certain lease by and between BRE/COH GA LLC, a Delaware limited liability company, as landlord, and Clearside Biomedical, Inc., a Delaware corporation, as tenant, and/or any
amendment to the lease or any other agreement between such parties related to the lease.” 

 It is a condition of this
Irrevocable Standby Letter of Credit that it will be considered automatically renewed for a one year period upon the expiration date set forth above and upon each anniversary of such date, unless at least 60 days prior to such expiration date or


  
 G-1 








 
applicable anniversary thereof, we notify you in writing, by certified mail return receipt requested or by recognized overnight courier service, that we elect not to so renew this Irrevocable
Standby Letter of Credit. A copy of any such notice shall also be sent, in the same manner, to: BRE/COH GA LLC, c/o Lincoln Property Company, 900 North Point Parkway, Suite 100, Alpharetta, Georgia 30005, Attention: Property Manager Property
Manager. In addition to the foregoing, we understand and agree that you shall be entitled to draw upon this Irrevocable Standby Letter of Credit in accordance with 1 and 2 above in the event that we elect not to renew this Irrevocable Standby Letter
of Credit and, in addition, you provide us with a dated statement purportedly signed by an authorized signatory or agent of Beneficiary stating that the Applicant has failed to provide you with an acceptable substitute irrevocable standby letter of
credit in accordance with the terms of the above referenced lease. We further acknowledge and agree that: (a) upon receipt of the documentation required herein, we will honor your draws against this Irrevocable Standby Letter of Credit without
inquiry into the accuracy of Beneficiary’s signed statement and regardless of whether Applicant disputes the content of such statement; (b) this Irrevocable Standby Letter of Credit shall permit partial draws and, in the event you elect to
draw upon less than the full stated amount hereof, the stated amount of this Irrevocable Standby Letter of Credit shall be automatically reduced by the amount of such partial draw; and (c) you shall be entitled to transfer your interest in this
Irrevocable Standby Letter of Credit from time to time and more than one time without our approval and without charge. In the event of a transfer, we reserve the right to require reasonable evidence of such transfer as a condition to any draw
hereunder. The correctness of the signature of the person signing the transfer forms must be verified by your bank or a notary public. 

This Irrevocable Standby Letter of Credit is subject to the International Standby Practices (ISP98) ICC Publication No. 590. 

We hereby engage with you to honor drafts and documents drawn under and in compliance with the terms of this Irrevocable Standby Letter of
Credit. 
 All communications to us with respect to this Irrevocable Standby Letter of Credit must be addressed to our office located at
                                         
                    to the attention of
                                         
                   . 
  

	
	Very truly yours,
	
	  

	
	
                     
               [name]

	
	
                     
               [title}




  
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