### NOTICE OF OFFICE OF MANAGEMENT AND BUDGET ACTION
Environmental Protection Agency Office of Prevention, Pesticides and Toxic Substances FOR CERTIFYING OFFICIAL: Linda Travers FOR CLEARANCE OFFICER: Rick Westlund
In accordance with the Paperwork Reduction Act, OMB has taken action on your request received 04/15/2009
ACTION REQUESTED: New collection (Request for a new OMB Control Number) TYPE OF REVIEW REQUESTED: Regular ICR REFERENCE NUMBER: 200904-2070-001 AGENCY ICR TRACKING NUMBER: 2249.01 TITLE: Tier 1 Screening of Certain Chemicals Under the Endocrine Disruptor Screening Program (EDSP) LIST OF INFORMATION COLLECTIONS: See next page
OMB ACTION: Approved with change OMB CONTROL NUMBER: 2070-0176 The agency is required to display the OMB Control Number and inform respondents of its legal significance in accordance with 5 CFR 1320.5(b).

EXPIRATION DATE: 10/31/2012 DISCONTINUE DATE:

BURDEN: RESPONSES HOURS COSTS Previous 0 0 0 New 1,287 161,415 0 Difference Change due to New Statute 903 161,172 0

### NOTICE OF OFFICE OF MANAGEMENT AND BUDGET ACTION

Change due to Agency Adjustment 0 0 0 Change Due to Potential Violation of the PRA 0 0 0
TERMS OF CLEARANCE: This information collection is approved for the 67 chemicals published by EPA at 74 Fed. Reg. 17579 (April 15, 2009). OMB appreciates the continuing dialog with respect to the practical utility of the Tier I battery of EDSP assays and the role that the results from these first 67 chemicals will play in ensuring practical utility for subsequent groups of chemicals. Nonetheless, under the principles of the PRA, EPA should promote and encourage test order recipients to submit Other Scientifically Relevant Information (OSRI) in lieu of performing all or some of the Tier I assays, and EPA should accept OSRI as sufficient to satisfy the test orders to the greatest extent possible. For this reason, and to further validate EPA’s burden estimates, O MB requests that EPA provide a report re-estimating the burden of this information collection based on responses to the Tier I test orders, including the use of cost-sharing and data compensation, the submission and acceptance of existing data and OSRI, and description of any instances in which submission of OSRI was deemed insufficient to satisfy the testing order. OMB requests this report prior to or at the time of submission of revision of this information collection to cover additional chemicals. In addition, in order to ensure that EPA has maximized the practical utility of the Tier I assays as the program moves forward, EPA should ensure sufficient opportunity prior to submission of any revision to this collection for public comment and peer review of the EPA tools to be developed to guide agency decisions on whether a chemical must proceed to Tier II, including the Weight of the Evidence Approach and Standard Evaluation Procedures.
OMB Authorizing Official: Kevin F. Neyland Deputy Administrator, Office Of Information And Regulatory AffairsList of ICs CFR Citation Form Name IC Title Form No. 40 CFR 169.2(k) Recordkeeping Optional Questionnaire Level of Effort for Recipients of Tier 1 Screening Orders Optional Questionnaire 6300-05-Q

Initial Response Form for Consortium/ Task Force, Initial Response Form for Individual Order Recipients Data Submitters 6300-05-C, 6300-05