Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF 

PREVENTION, PESTICIDES 

AND TOXIC SUBSTANCES 

MEMORANDUM

DATE: 17-April-2007 

SUBJECT: PP# 9E6006 Metiram Acute, Chronic, and Cancer Dietary Exposure Assessments for 

New Tolerances on Imported Grapes and Bananas. 

PC Code: 014601 

DP Number: 326753 

REVIEWER: Christine L. Olinger, Chemist 

Reregistration Branch I 

Health Effects Division (7509P) 

THROUGH: Michael S. Metzger, Chief 

Reregistration Branch 1 

Health Effects Division (7509P) 

Sheila Piper, Chemist 

Felecia Fort, Chemist 

Dietary Exposure Science Advisory Council 

Health Effects Division (7509P) 

TO: Cynthia Giles-Parker, Chief 

Fungicide Branch 

Registration Division (7505P) 

Executive Summary

BASF Corporation has submitted a petition for tolerances on imported bananas and grapes for the 

fungicide metiram. Metiram is in the class of ethylene bisdithiocarbamate fungicides (EBDCs), which 

all produce the common metabolite and environmental degradate, ethylene thiourea (ETU). This 

memorandum reports the results of a dietary exposure analysis for metiram and ETU, resulting from 

applications of metiram. A separate memorandum will report the results of an analysis of the aggregate 

exposure of ETU from all of the EBDCs. The most recent dietary exposure analysis was conducted in 

support of the reregistration of the EBDCs (F. Fort, 6/1/2006, DP Number 291664), which included the 

proposed tolerance on wine grapes using preliminary residue data. 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

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Acute, chronic, and cancer dietary exposure assessments were performed for the general U.S. population 

and various population subgroups to determine the exposure and risk estimates which result from the 

use of metiram and ETU. Tolerances are currently established in 40 CFR 180.217 for apples (0.1 ppm) 

and potatoes (0.05 ppm). The petitioner has proposed import tolerances for grapes and bananas; HED 

has recommended levels of 5 and 3 ppm, respectively, based on the residue data submitted. No residues 

are expected in livestock; therefore, no tolerances are needed to cover secondary residues in livestock 

commodities (Category 3 of 40 CFR §180.6(a)). Field trial data and percent crop treated information 

were used for apple and wine grapes; EBDC Market Basket Survey data were used for potatoes. 

Acute Dietary Exposure Results 

For Metiram, the acute risk estimates are below the Agency’s level of concern at the 99.9th exposure 

percentile for females 13-49 years old, the population subgroup of concern (19% of the aPAD). Acute 

risk estimates for females 13-49 years old are also below HED’s level of concern for ETU with 70% of 

the aPAD occupied for food and water. 

 

Chronic Dietary Exposure Results

The chronic risk estimates are below the Agency’s level of concern for metiram and ETU for the general 

U.S. population and all population subgroups. The most highly exposed population subgroup is children 

ages 1-2 with an estimate for metiram for food alone of 70% of the cPAD. For ETU from metiram 

sources, the estimate for children ages 1-2 is at 50% of the cPAD for food alone, and 54% for food and 

water combined. 

Cancer Dietary Exposure Results

The cancer risk estimate associated with exposure to ETU from metiram is 1.4 x 10-6 for the general 

U.S. population, and is below the Agency’s level of concern. 

The acute, chronic, and cancer assessments can be considered somewhat refined. Residue estimates 

were refined using consumer processing factors (washing, cooking), commercial processing 

(winemaking, juice), percent crop treated factors (domestic uses only), and monitoring data for one 

commodity (potatoes). Percent crop treated information is not available for the uses on imported crops 

(bananas and grapes), residue estimates were refined slightly using percent imported. Crop field trial 

data were used for all crops except potatoes, which are likely to provide higher estimates than actual 

exposures. 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and 

chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose 

which HED has concluded will result in no unreasonable adverse health effects). This dose is referred 

to as the population adjusted dose (PAD). The PAD is equivalent to point of departure (POD, NOAEL, 

LOAEL, e.g.) divided by the required uncertainty or safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 
Metiram Dietary Exposure Assessment DP Number: 326753 

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100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one in one million. 

References which discuss the acute and chronic risk assessments in more detail are available on the 

EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s 

Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; 

or see SOP 99.6 (20-AUG-1999). 

The most recent dietary exposure analysis was conducted in support of the reregistration of the EBDCs 

(F. Fort, 6/1/2006, DP Number 291664), which included the proposed tolerance on wine grapes using 

preliminary residue data. 

II. Residue Information

In 1977, the Agency initiated a Special Review and Continued Registration of Pesticide Products 

containing ethylene bisdithiocarbamates (EBDCs); metiram belongs to the EBDC group of fungicides. 

The need for Special Review of the EBDCs was based on evidence suggesting that the EBDCs and 

ethylene thiourea (ETU), a metabolite and degradation product of these pesticides posed potential risks 

to human health and the environment. In 1982, the Agency concluded this Special Review by issuing a 

Final Determination (PD 4) which required risk reduction measures to prevent unreasonable adverse 

effects pending development and submission of additional data needed for improved risk assessment. 

In 1987, EPA issued a second Notice of Initiation of Special Review of the EBDC pesticides because of 

health concerns caused by ETU. The Special Review’s Preliminary Determination (PD 2/3) was 

published on 12/20/89 (54 FR 52158) and the Final Determination (PD 4) on 3/2/92 (57 FR 7484). It 

was determined that the dietary risks of EBDCs exceed the benefits for the following food/feed uses for 

which one or more of the EBDC pesticides are registered: apricots, carrots, celery, collards, mustard 

greens, nectarines, peaches, rhubarb, spinach, succulent beans, and turnips. Accordingly, EPA has 

canceled all metiram and other EBDC products registered on the above-listed food/feed crops. 

Currently, the only food/feed uses of metiram eligible for continued registration are apples and potatoes. 

Metiram tolerances are established under 40 CFR §180.217 and are currently expressed in terms of 

residues of a fungicide that is a mixture of 5.2 parts by weight of ammoniates of 

[ethylenebis(dithiocarbamato)]zinc with 1 part by weight ethylenebis [dithiocarbamic acid] bimolecular 

and trimolecular cyclic anhydrosulfides and disulfides, calculated as zinc ethylenebisdithiocarbamate 

(zineb). The HED Metabolism Assessment Review Committee (MARC) has recommended a change in 

the tolerance expression for metiram and the other EBDCs with registered uses, mancozeb and maneb. 

The EBDC tolerance expressions will be revised to include residues of the parent EBDC only, 

calculated as CS2, rather than as zineb. Dietary exposure and risk assessments will continue to include 

residues of ethylene thiourea (ETU), a metabolite common to all EBDCs. This change will serve to 

update the CFR to include only those EBDCs with registered uses, and will also allow the Agency to 

harmonize its EBDC tolerance definitions with CODEX. The Metiram Update concluded that analytical 

methods converting EBDCs and some metabolites to carbon disulfide will be considered adequate for 

enforcement, along with a specific method for ETU. 

Residue Data used for Acute, Chronic, and/or Cancer Assessments:
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A summary of the residue inputs can be found as an attachment to this document. BASF Corporation 

submitted banana and grape residue data, as well as grape processing data. Detailed information on the 

derivation of the existing uses of metiram may be found in the original anticipated residue memorandum 

(F. Fort, 10/21/2003, DP Number 290038). Attachment 1 to this document includes a detailed 

description of the estimation of the anticipated residues for the proposed new tolerances. 

Acute Anticipated Residues

For the probabilistic acute dietary exposure analysis, the entire distribution of residue data from field 

trials or monitoring data were used to generate residue distribution files (RDFs) for commodities that are 

considered to be not blended or partially blended (see Attachments). For commodities considered to be 

blended in this analysis, the average residues incorporating the likely maximum estimated % CT was 

used as a point estimate. Processing and cooking factors from studies with metiram and other EBDCs 

were used as well. 

Chronic Anticipated Residues

Chronic anticipated residues were also calculated from field trial or monitoring data for metiram and 

ETU. Averages of the field trials were used for the new tolerances, while field trial and market basket 

survey data were used for established uses. Processing and cooking factors from studies with metiram 

and other EBDCs were used as well. 

Usage Data

BEAD provided information (J. Carter, 3/22/05, Attachment 3) on the percent crop treated (%CT) for 

the existing uses. Percent imported was used as a surrogate for percent crop treated as all of the 

proposed new tolerances are for imported commodities, and percent crop treated information from the 

foreign uses are not available. BEAD estimated 100% imported for bananas, 44% for fresh grapes (also 

used for dried grapes and grape juice), and 20% for wine (J. Alsadek, 8/11/2006, Attachment 4). For the 

chronic analysis, the weighted average %CT was incorporated; for the acute analysis, the estimated 

maximum %CT was used when appropriate. 

In acute analyses (except blended commodities) the adjustment for %CT is incorporated in the residue 

distribution files (RDFs) via addition of zero residue values corresponding to the % of crop not treated. 

For blended/not further processed commodities where monitoring data are available, the entire 

distribution of monitoring data with no further adjustment for %CT were used. For blended/processed 

commodities where monitoring data are available and for all blended commodities where field trial data 

were used, %CT is incorporated into a point estimate. For the chronic analyses, the %CT is listed as 

Adjustment Factor 2 in the DEEM analysis. 

Processing Factors

The metiram processing factors were obtained from processing studies submitted by the registrant and 
Metiram Dietary Exposure Assessment DP Number: 326753 

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were compiled in a memo entitled “Reregistration of Mancozeb, Maneb, and Metiram: Processing and 

Cooking Factors to be Used in the Dietary Risk Assessment”, C. Olinger, October 2003. These factors 

include cooking, peeling, washing and processing factors. Wine processing data from metiram specific 

studies submitted in support of the petition were used as well. 

III. Drinking Water Data 

The Environmental Fate and Effects Division (EFED) has provided information on the ability of 

metiram and the degradate ETU to reach drinking water sources. (Ruhman and Parker, 8/11/06, DP 

Numbers 323143 and 323141). Metiram, like the other EBDC fungicides, are expected to degrade 

relatively quickly in the environment, so is not expected to reach drinking water sources. EFED has 

estimated drinking water concentrations of ETU in surface water and groundwater using monitoring 

data, and modeled estimates where monitoring data are not available. According to the 8/11/06 memo, 

• the chronic EDWC for surface water is 0.1 ppb of ETU based on a monitoring study conducted by 

the EBDC Task Force; 

 

• A range of acute EDWCs is established with a lower limit of 0.1 ppb of ETU (based on monitoring) 

and an upper limit of 25.2 ppb of ETU (based on environmental fate and transport simulation 

modeling using the linked EPA PRZM and EXAMS models); and 

 

• The ground water EDWC is 0.21 ppb of ETU (based on a targeted monitoring study). 

Water residues were incorporated in the DEEM-FCID into the food categories “water, direct, all 

sources” and “water, indirect, all sources.” The upper limit from PRZM/EXAMS was used for the acute 

assessment and the groundwater EDWC was used for the chronic and cancer assessments, as these 

estimates provided an upper bound estimate of water exposure. 

IV. DEEM-FCIDTM Program and Consumption Information

Metiram acute, chronic and cancer dietary exposure assessments were conducted using the Dietary 

Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCIDTM, Version 

2.03), which incorporates consumption data from USDA’s Continuing Surveys of Food Intakes by 

Individuals (CSFII), 1994-1996 and 1998. The 1994-96, 98 data are based on the reported consumption of 

more than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) 

are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or 

wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly 

by USDA/ARS and EPA. Consumption data are averaged for the entire U.S. population and within 

population subgroups for chronic exposure assessment, but are retained as individual consumption events 

for acute exposure assessment. 

For chronic exposure and risk assessment, an estimate of the residue level in each food or food-form (e.g., 

orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption 

estimate for that food/food form. The resulting residue consumption estimate for each food/food form is 

summed with the residue consumption estimates for all other food/food forms on the commodity residue list 
Metiram Dietary Exposure Assessment DP Number: 326753 

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to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a 

percent of the cPAD. This procedure is performed for each population subgroup. 

For acute exposure assessments, individual one-day food consumption data are used on an individualby-individual basis. The reported consumption amounts of each food item can be multiplied by a 

residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic 

exposure assessment, or “matched” in multiple random pairings with residue values and then summed in 

a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the 

aPAD on both a user (i.e., those who reported eating relevant commodities/food forms) and a per-capita 

(i.e., those who reported eating the relevant commodities as well as those who did not) basis. In 

accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis. 

However, for deterministic assessments, significant differences in user vs. per capita exposure and risk 

are identified and noted in the risk assessment. 

V. Toxicological Information

The HED Hazard Identification Assessment Review Committee (HIARC) on February 20, 2003 

reevaluated the toxicology data base of metiram and ETU and selected toxicology endpoints for chronic 

and acute dietary as well as cancer for ETU. The selected toxicological endpoints and the doses for risk 

assessment and additional relevant details are summarized in Table 1. Based on the weight of evidence 

presented, the HIARC determined that a 10X database uncertainty factor (UFDB) is needed for metiram 

to account for the lack of 1) Acute Neurotoxicity Study in the Rat; 2) Developmental Toxicity Study in 

the Rabbit; 3) Two-Generation Reproduction Study in the Rat; 4) Developmental Neurotoxicity Study 

in the Rat; and 5) Comparative Thyroid Assay Between Adult and Young Animals studies since the 

available data provide no basis to support reduction or removal of the default 10X factor. For ETU, the 

HIARC concluded that a Database Uncertainty Factor of 10x is required until a developmental 

neurotoxicity study is received and evaluated. 

The HED Cancer Assessment Review Committee classified ETU as a group B2 probable human 

carcinogen (Bill Sette, Ph.D. memo, 4/16/90 and Albin Kocialski, Ph.D. memo, 9/26/91). The Q1* for 

ETU, using a 3/4 scaling factor, was determined to be 6.01 x 10-2 mg/kg/day-1 based upon female mouse 

liver tumors in the NTP study (Bernice Fisher and Hugh Pettigrew memo, 2/24/95). The Q1* for ETU is 

also used for the EBDC compounds, mancozeb, metiram, and maneb which are metabolized to ETU 

(HED Document No. 013554, 7/7/99). 

Table 1. Summary of Toxicology Endpoint Selection for Metiram and ETU 
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Exposure 

Scenario 

Point of Departure/ 

Uncertainty and 

FQPA Safety 

Factors 

Level of Concern for 

Risk Assessment Study and Toxicological Effects 

METIRAM 

Acute Dietary

females 13-50 years 

of age

NOAEL = 10 

mg/kg/day 

UFA= 10x UFH=10x 

FQPA SF= 10x 

[Database 

Uncertainty Factor ] 

Acute RfD = 0.01 

mg/kg/day 

aPAD = 

= 0.01 mg/kg/day 

Rabbit developmental toxicity study

LOAEL = 40 mg ai/kg/day based on 

abortions 

Acute Dietary

general population

including infants and 

children 

NOAEL = N/A No appropriate endpoint from oral toxicity studies was identified. 

Chronic Dietary

(All populations) 

NOAEL = 0.4 

mg/kg/day 

UFA= 10x UFH=10x 

FQPA SF= 10x 

[Database 

Uncertainty Factor ] 

Chronic RfD = 0.0004

mg/kg/day 

cPAD = 

=0.0004 mg/kg/day 

Subchronic oral toxicity study in rats

LOAEL = 5.8 mg/kg/day, based on 

decreased forelimb grip strength 

ETU 

Acute Dietary 

Females 13-50 years 

age

NOAEL = 5 

mg/kg/day 

UFA= 10x UFH=10x 

FQPA SF= 10x 

[Database 

Uncertainty Factor ] 

Acute RfD = 0.005 

mg/kg/day 

aPAD = 0.005 

mg/kg/day

Developmental rat study (Khera) 

LOAEL = 10 mg/kg/day based on 

developmental defects of brain. 

Acute Dietary

General Population

including 

infants/children 

NOAEL = N/A No appropriate endpoint from oral toxicity studies was identified. 

Chronic Dietary 

All populations

NOAEL = 0.18 

mg/kg/day 

UFA= 10x UFH=10x 

FQPA SF= 10x 

[Database 

Uncertainty Factor ] 

Chronic RfD = 0.0002 

mg/kg/day 

cPAD = 0.0002 

mg/kg/day

Dog chronic toxicity study. 

LOAEL = 1.99 mg/kg/day based on thyroid 

toxicity. 

Carcinogenicity Q1* = 0.0601 

(mg/kg/day)-1

B2 carcinogen with low-dose extrapolation for human risk assessment 

based on liver tumors in female mice. 

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to 

mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. 

NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA = 

extrapolation from animal to human (intraspecies). UFH = potential variation in sensitivity among members of the human 

population (interspecies). UFDB = to account for the absence of key date (i.e., lack of a critical study). FQPA SF = FQPA 

Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. N/A = not applicable.
Metiram Dietary Exposure Assessment DP Number: 326753 

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VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% 

of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. population and 26 

population subgroups. The results reported in Table 2 are for females 13-49 years old, the population 

subgroup of toxicological concern for acute assessments and in Table 3 (chronic assessments) are for the 

general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50+ years. Cancer risk is determined for the general U.S. 

population only. 

Results of Acute Dietary Exposure Analysis

Acute assessments were conducted for metiram and ETU and are presented in Table 2. Results are 

reported at the 99.9th percentile of exposure because the assessment incorporated anticipated residues 

and estimates of %CT. 

Table 2. Results of Acute Dietary Exposure Analysis for Metiram and ETU 

Population Subgroup aPAD 

(mg/kg/day) 

95th Percentile 99th Percentile 99.9th Percentile 

Exposure 

(mg/kg/day) 

% 

aPAD 

Exposure 

(mg/kg/day) 

% 

aPAD 

Exposure 

(mg/kg/day) % aPAD 

Metiram

Females 13-49 years old, 

Food Only 

0.01 0.000169 1.7 0.000654 6.5 0.00193 19 

ETU

Females 13-49 years old, 

Food Only 

0.005 0.000066 1.3 0.000138 2.8 0.000299 6.0 

Females 13-49 years old, 

Food and Water 

0.005 0.001242 25 0.00199 40 0.003511 70 

 

The results indicate that dietary risk estimates for metiram and ETU are not of concern for the 

population subgroup of concern, females 13-49 years old. 

Results of Chronic Dietary Exposure Analysis

Chronic assessments were conducted for metiram and ETU and are presented in Table 3 for metiram, 

and Table 4 for ETU. 

Table 3. Results of Chronic Dietary Exposure Analysis for Metiram 

Population Subgroup cPAD 

(mg/kg/day) 

Exposure (mg/kg/day) % cPAD 

General U.S. Population 0.0004 0.000048 12 

All Infants (< 1 year old) 0.0004 0.000052 13 
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Table 3. Results of Chronic Dietary Exposure Analysis for Metiram 

Population Subgroup cPAD 

(mg/kg/day) 

Exposure (mg/kg/day) % cPAD 

Children 1-2 years old 0.0004 0.000281 70 

Children 3-5 years old 0.0004 0.000163 41 

Children 6-12 years old 0.0004 0.000063 16 

Youth 13-19 years old 0.0004 0.000022 5.4 

Adults 20-49 years old 0.0004 0.000028 6.9 

Adults 50+ years old 0.0004 0.000039 9.7 

Females 13-49 years old 0.0004 0.000030 7.4 

Table 4. Results of Chronic Dietary Exposure Analysis for ETU from Metiram

Population Subgroup cPAD 

(mg/kg/day) 

ETU – Food Only ETU – Food and Water 

Exposure 

(mg/kg/day) % cPAD Exposure (mg/kg/day) % cPAD 

General U.S. Population 0.0002 0.000018 9 0.000022 11 

All Infants (< 1 year old) 0.0002 0.000051 25 0.000065 33 

Children 1-2 years old 0.0002 0.0001 50 0.000107 54 

Children 3-5 years old 0.0002 0.000056 28 0.000063 31 

Children 6-12 years old 0.0002 0.000022 11 0.000027 13 

Youth 13-19 years old 0.0002 0.000008 3.8 0.000011 5.4 

Adults 20-49 years old 0.0002 0.00001 5.1 0.000014 7.1 

Adults 50+ years old 0.0002 0.000015 7.6 0.000020 9.8 

Females 13-49 years old 0.0002 0.000011 5.3 0.000015 7.4 

** The values for the highest exposed population for each type of risk assessment are bolded. 

The results indicate that chronic dietary risk estimates for metiram and ETU are not of concern for the 

all population subgroups. 

Results of Cancer Dietary Exposure Analysis

Exposure and risk estimates for the ETU cancer assessment are presented in Table 5. Because of the 

uncertainties regarding estimation of cancer potency and human exposure, risk estimates ranging from 1 

to 3 x10-6 are generally considered indistinguishable. The estimated cancer risk for food alone and 

aggregated food and water are within this range and are not of concern. 

Table 5. Results of Cancer Dietary Exposure Analysis for ETU from Metiram 

Population Subgroup Exposure 

(mg/kg/day) Estimated Cancer Risk 

General U.S. Population – Food Only 0.000018 1.1 x 10-6

General U.S. Population – Food and Water 0.000022 1.4 x 10-6
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VII. Characterization of Inputs/Outputs

The exposure assessments can be considered somewhat refined, as some inputs are conservative, while 

others can be considered highly refined. 

• Field trial data were used for apples, bananas, and grapes. These data are generally considered 

to be conservative as samples are taken directly from the field and do not reflect any weathering 

that may occur during packaging and shipping. They also reflect the maximum use rates on the 

product label; typical use rates may be lower. 

• Market basket survey (MBS) data were used for potatoes. The analytical method used to 

measure residues of EBDC fungicides cannot distinguish between mancozeb, maneb, and 

metiram, which are all registered for use on potatoes. For this assessment HED assumed all of 

the EBDC residues found were from metiram, so these estimates are considered an overestimate. 

• Percent crop treated data were used for apples and potatoes. 

• Percent crop treated information are not available for imported grapes, grape products, and 

bananas. HED used percent imported data, so it was assumed that all bananas and grapes 

imported in the US have been treated with metiram. It is unlikely that all of these imported 

commodities have been treated. 

• Consumer practice processing factors for procedures such as washing and cooking are available 

and were incorporated into the assessment, providing more refined exposure estimates. 

• Residue estimates were refined using factors reflecting commercial processing, such as wine 

production. 

• Estimates of residues in wine were determined by applying processing factors to grape field trial 

data. Monitoring studies for the other EBDC fungicides on domestic wine generally found much 

lower residues than the estimates used in this assessment. 

VIII. Conclusions

The probabilistic acute and chronic dietary risk assessments were conducted for all supported metiram 

food uses and the proposed import tolerance bananas and grapes. For metiram, the acute risk estimates 

are below the Agency’s level of concern at the 99.9th exposure percentile for females 13-49 years old, 

the population subgroup of concern (19% of the aPAD). Acute risk estimates for females 13-49 years 

old are also below HED’s level of concern for ETU with 70% of the aPAD occupied for food and water. 

 The chronic risk estimates are below the Agency’s level of concern for metiram and ETU for the 

general U.S. population and all population subgroups. The most highly exposed population subgroup is 

children ages 1-2 with an estimate for metiram for food alone is 70% of the cPAD. For ETU from 

metiram sources, the estimate for children ages 12 is at 50% of the cPAD for food alone, and 54% for 

food and water combined. The cancer risk estimate associated with exposure to ETU from metiram is 

1.4 x 10-6 for the general U.S. population, and is below the Agency’s level of concern. 
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VIII. List of Attachments

Attachment 1: Estimation of Anticipated Residues for Proposed New Tolerances 

Attachment 2: Anticipated Residue Summary and Residue Distribution Files for Existing Uses 

Attachment 3: Screening Level Usage Analysis for Existing Uses of Metiram 

Attachment 4: BEAD Memo on Percent Imported for Bananas and Grapes 

Attachment 5: Residue Input File – Metiram Acute Analysis – Food Only 

Attachment 6: Residue Input File – Metiram Chronic Analysis – Food Only 

Attachment 7: Results File – Metiram Acute Analysis – Food Only 

Attachment 8: Results File Metiram Chronic Analysis – Food Only 

Attachment 9: Residue Input File – ETU Acute Analysis – Food Only 

Attachment 10: Residue Input File – ETU Acute Analysis – Food and Water 

Attachment 11: Residue Input File – ETU Chronic Analysis – Food Only 

Attachment 12: Residue Input File – ETU Chronic Analysis – Food and Water 

Attachment 13: Results File – ETU Acute Analysis – Food Only 

Attachment 14: Results File – ETU Acute Analysis – Food and Water 

Attachment 15: Results File – ETU Chronic Analysis – Food Only 

Attachment 16: Results File – ETU Chronic Analysis – Food and Water 

Attachment 17: Results File – ETU Cancer Analysis – Food Only 

Attachment 18: Results File – ETU Cancer Analysis – Food and Water 
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Attachment 1: Estimation of Anticipated Residues for Proposed New Tolerances 

Crop field trial data were used to estimate anticipated residues for the proposed new tolerances on 

imported bananas and grapes. A detailed discussion of the data used may be found in the residue 

chemistry summary document (C. Olinger, DP Number 322230, in review). Processing factors for grape 

processed products were derived from processing studies submitted in association with the petition. 

Additionally, processing factors for consumer practices such as washing and cooking were used 

(Reregistration of Mancozeb, Maneb, and Metiram: Processing and Cooking Factors to be Used in the 

Dietary Risk Assessment”, C. Olinger, 11/5/2003, DP Numbers 289569; 289570; 289571). 

Calculation of Residue Estimates

Metiram residues in the raw agricultural commodity were multiplied by relevant processing factors to 

obtain the estimate of residues in the food as consumed. Ethylenethiourea (ETU) residues in/on raw 

agricultural commodities (RAC) were adjusted for processing factors. In addition, approximately 7.5% 

of the metiram consumed converts to ETU in the body; this metabolic ETU must be considered when 

estimating ETU exposure through food. Total ETU residues in foods consist of ETU in the raw or 

processed commodities plus the metabolic ETU from parent EBDC. EBDCs may also be converted to 

ETU during processing, usually when the process involves heating. Below are the formulae used to 

calculate ETU residue estimates, including both conversion during processing as well as the metabolic 

ETU: 

Raw Agricultural Commodities: 

 [ETU]AR = [ETU]RAC + ([EBDC]RAC X 0.075 X PF1) 

 where 

 [ETU]AR = ETU anticipated residue estimate 

 [ETU]RAC = ETU concentration as measured in the RAC 

 [EBDC]RAC = EBDC concentration as measured in the RAC 

 0.075 = metabolic conversion factor 

 PF1 = consumer processing factor (such as peeling, washing, trimming) 

Processed Commodities: 

 [ETU]AR = ([ETU]RAC X PF2) + ([EBDC]RAC X 0.075 X PF3) + ([EBDC]RAC X CF) 

 where 

 [ETU]AR = ETU anticipated residue estimate 

 [ETU]RAC = ETU concentration as measured in the RAC 

 PF2 = ETU processing factor (e.g. cooking) 

 [EBDC]RAC = EBDC concentration as measured in the RAC 

 0.075 = metabolic conversion factor 

 PF3 = processing factor (such as peeling, washing, trimming, cooking) 

 CF = conversion factor for conversion of EBDC to ETU 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 13 of 62 

Sample Calculation:

Given a raw cucumber sample bearing EBDC residues of 0.17 ppm and ETU residues of 0.02 ppm;

EBDC Cooking Factor is 0.0114, ETU cooking factor is 0.87, EBDC to ETU Conversion Factor is 5.3%,

and the in vivo metabolic conversion factor is 7.5 %.

EBDC Residues in Cooked Cucumber:

[EBDC]raw x CF = [EBDC]cooked

0.17 ppm x 0.114 = 0.005 ppm

Total ETU Residues in Cooked Cucumber

[ETU]AR = ([ETU]RAC X PF2) + ([EBDC]RAC X 0.075 X PF3) + ([EBDC]RAC X CF)

Loss of ETU Residues from Cooking

([ETU]RAC X PF2)

0.02 ppm * 0.87 = 0.017 ppm

In vivo Conversion of EBDC residues in cooked commodity to ETU

([EBDC]RAC X 0.075 X PF3)

0.17 ppm * 0.075 * 0.0114 = 0.00014

Conversion of Raw EBDC residues in Raw commodity to ETU during cooking

[EBDC]RAC X CF

0.17 ppm * 0.053 = 0.0089

Total ETU Residues = 0.017 + 0.00014 + 0.0089 = 0.026 ppm

Summary Tables

The tables on the following pages provide a summary of the anticipated residues used in the dietary 

exposure assessment. 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 14 of 62 

Table 1-1. Metiram Anticipated Residues for Proposed Import Tolerances 

Crop Field Trial or Monitoring Data Percent Imported Average Residue Value, ppm 2 Chronic Anticipated Residue, ppm 3 Commodity Processing Factor R

Dis

An

Bananas FT 100 0.05 

0.05 Pulp 1 

0.003 Cooked, cooked pulp 0.06 

0.0135 Dried Pulp 0.27 

0.00081 Dried, cooked Pulp 0.0162 

Grapes FT 

44 

1.63 

0.0863 Washed 0.12 

44 0.00518 Cooked 0.0072 

44 5 0.285 Washed, Dried 0.396 44 5 0.0171 Washed, dried, cooked 0.0238 

20 0.327 Wine, uncooked 0.1 20 0.00196 Wine, cooked 0.006 

44 5 0.0719 Juice 0.1 44 5 0.00432 Juice, cooked 0.006 

Footnotes: 1 Percent imported obtained from BEAD Quantitative Projected Percent Crop Treated by Jihad Alsadek, dated August 11, 2006 2 Average value from data source used for anticipated residue. 3 Chronic Anticipated Residue value includes correction for percent crop treated and processing. 4 RDF files are used for partially blended or non-blended commodities and are uncorrected for percent crop treated or processing. A

blended commodities ARE corrected for percent crop treated and processing. 5 Percent imported values specific to juice and raisins were not available at the time of the review, so the percent crop treated for fres
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 15 of 62 

Table 1-2. Anticipated Residues for Residues of ETU from Metiram Proposed Import Tolerances 

Crop Field Trial or Monitoring Data Percent Imported Average Residue Value, ppm 2 Chronic Anticipated Residue, ppm 3 Commodity Residue D

Distribution 

Anticipated 

Bananas FT 100 

0.0313 0.0313 Pulp RDF – Uncook

0.0236 0.0236 Cooked, cooked pulp RDF – Cooke0.0282 0.0282 Dried Pulp 0.0280.0236 0.0236 Dried, cooked Pulp 0.023

Grapes FT 

44 0.0352 0.0155 Washed RDF – wash

44 0.0262 0.0115 Cooked RDF – cook

44 5 0.069 0.0304 Washed, Dried RDF – r44 5 0.0211 0.00928 Washed, dried, cooked RDF – cook

20 0.0327 0.00654 Wine, uncooked RDF – 20 0.0189 0.00378 Wine, cooked RDF – cook

44 5 0.0327 0.0144 Juice RDF – Gra44 5 0.0189 0.00832 Juice, cooked RDF - G

Footnotes: 1 Percent imported obtained from BEAD Quantitative Projected Percent Crop Treated by Jihad Alsadek, dated August 11, 2006 2 Average value from data source used for anticipated residue. 3 Chronic Anticipated Residue value includes correction for percent crop treated and processing. 4 RDF files are used for partially blended or non-blended commodities and are uncorrected for percent crop treated or processing. A

blended commodities ARE corrected for percent crop treated and processing. 5 Percent imported values specific to juice and raisins were not available at the time of the review, so the percent crop treated for fres
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 16 of 62 

Table 1-3. New Residue Data files for the Acute Dietary Analysis Metiram – Grapes Grapes 44% CT TOTALZ=37 TOTALNZ=29 0.36 0.61 3.02 0.41 1.86 1.41 0.77 3.23 0.85 1.47 1.4 0.86 1.32 1.95 0.75 1.73 1.78 2.69 2.84 1.1 2.2 1.8 2.4 2 3.1 0.6  0.6 1.8 2.5 

Metiram – Wine Grapes Wine Grapes 20% CT TOTALZ=116 TOTALNZ=29 0.36 0.61 3.02 0.41 1.86 1.41 0.77 3.23 0.85 1.47 1.4 0.86 1.32 1.95 0.75 1.73 1.78 2.69 2.84 1.1 2.2 1.8 2.4 2 3.1 0.6  0.6 1.8 2.5 

Metiram – BananasBananas 100% CT TOTALZ=0 TOTALNZ=24 0.025 0.09 0.05 0.08 0.025 0.05  0.025 0.11 0.05 0.14 0.05 0.2  0.025 0.05 0.025 0.05 0.025 0.07 0.05 0.05 0.025 0.025 0.025 0.025 

ETU – UncoETU from M44% CT TOTALZ=37 TOTALNZ=0.00824 0.0.0217 0.00.0327 0.00.0369 0.00.0300 0.00.0448 0.00.0529 0.00.0475 

ETU – Cooked GrapesETU from Metiram - cooked Grapes 44% CT TOTALZ=37 TOTALNZ=29 0.0062 0.00749 0.026 0.00646 0.0139 0.0116 0.00831 0.0601 0.0261 0.0293 0.0289 0.0262 0.0285 0.0318 0.0256 0.0306 0.0213 0.033 0.0276 0.0274 0.0330 0.0310 0.0341 0.0320 0.0377 0.0248 0.0248 0.0310 0.0346 

ETU – Uncooked WineETU from Metiram - uncooked wine 20% CT TOTALZ=116 TOTALNZ=29 0.0077 0.00958 0.0347 0.00808 0.019 0.0156 0.0108 0.0742 0.0314 0.0360 0.0355 0.0314 0.0349 0.0396 0.0306 0.038 0.0274 0.0422 0.0363 0.0332 0.0415 0.0385 0.043 0.04 0.0482  0.0295 0.0295 0.0385 0.0438 

ETU – Cooked WineETU from Metiram - cooked wine 20% CT TOTALZ=116 TOTALNZ=29 0.00459 0.00476 0.0125 0.00463  0.00561 0.00531 0.00487 0.0457  0.0223 0.0227 0.0227 0.0223 0.0226 0.0231 0.0223 0.0229 0.0134 0.021 0.015 0.0225 0.0232 0.023 0.0234 0.0231 0.0239 0.0222 0.0222 0.023 0.0234 

ETU – UncoETU from M44% CT TOTALZ=37 TOTALNZ=0.0077 0.00.019 0.010.0314 0.00.0349 0.00.0274 0.00.0415 0.0 0.0295 0.

ETU – Cooked Juice ETU from Metiram - cooked juice 44% CT TOTALZ=37 TOTALNZ=29 0.00459 0.00476 0.0125 0.00463  0.00561 0.00531 0.00487 0.0457  0.0223 0.0227 0.0227 0.0223 0.0226 0.0231 0.0223 0.0229 0.0134 0.021 0.015 0.0225 0.0232 0.023 0.0234 0.0231 0.0239 0.0222 0.0222 0.023 0.0234 

ETU – Uncooked RaisinsETU from Metiram - uncooked raisins 44% CT TOTALZ=37 TOTALNZ=29 0.0157 0.0231 0.102 0.0172 0.0602 0.0469 0.0279 0.146 0.0502 0.0687 0.0666 0.0505 0.0642 0.0829 0.0473 0.0764 0.0669 0.102 0.0993 0.0577 0.0903 0.0785 0.0963 0.0844 0.117 0.0428 0.0428 0.0785 0.0992 

ETU – Cooked RaisinsETU from Metiram - cooked raisins 44% CT TOTALZ=37 TOTALNZ=29 0.00508 0.00558 0.0165 0.00518  0.00811 0.0072 0.00591 0.0500278 0.0235 0.0247 0.0246  0.0235 0.0244 0.026 0.0233 0.0253 0.0158 0.0246 0.0188 0.024 0.0262 0.0254 0.0266 0.0258 0.0280 0.023 0.023 0.0254 0.0268 

ETU – UncoETU from M100% CT TOTALZ=0 TOTALNZ=0.0268 0.00.0269 0.00.0288 0.00.0269 0.00.0269 0.00.0269 0.0

ETU – Cooked Banana 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 17 of 62 

Table 1-3. New Residue Data files for the Acute Dietary Analysis ETU from Metiram - cooked 100% CT TOTALZ=0 TOTALNZ=24 0.0219 0.0224 0.0221 0.0223 0.0219 0.0221 0.0219 0.0225 0.0221 0.0444 0.0221 0.0449 0.0219 0.0221 0.0219 0.0221 0.0219 0.0222 0.0221 0.0221 0.0219 0.0219 0.0219 0.0219
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 18 of 62 

Attachment 2: Anticipated Residue Summary and Residue Distribution Files for Existing Uses Anticipated Residue Summary for Existing Uses of Metiram 

Commodity Data Source2 DEEM Food Form Blended Classification2

Metiram ETU 

Processing 

Factor 

Anticipated Residue 

(ppm) or RDF3 # EBDC to ETU 

Conversion 

Processing 

Factor 

An

(

Chronic/ 

Cancer Acute Chro

Can

Potato, chips Potato MBS data Cooked B 0.045 Cooking and Chips) 0.0034 0.00034 0.045 0.053 0.00

Potato, dry 

(granules/flakes) 

Potato 

MBS data Cooked B 0.102 (cooking and flake) 0.0034 0.00034 1.85 (flake) 0.87 0.0

Potato, dry 

(granules/flakes)-

babyfood 

Potato 

MBS data Cooked B 0.102 (cooking and flake) 0.0034 0.00034 1.85 (flake) 0.87 0.0

Potato, flour Potato MBS data Uncooked B 3.4 (flake) 0.0034 0.00034 1.85(flake) 1 0.00

Cooked B 0.102 (Cooking and Flake) 0.0034 0.00034 1.85 (flake) 0.87 0.0

Potato, flour - 

babyfood 

Potato 

MBS data 

Uncooked B 3.4 (flake) 0.0034 0.00034 1.85 (flake) 1 0.00

Cooked B 0.102 (Cooking and Flake) 0.0034 0.00034 1.85 (flake) 0.87 0.0

Potato, tuber 

w/peel 

Potato 

MBS data Cooked NB 0.011 (Washing/ cooking) 0.0034 RDF #1 0.053 0.87 0.00

Potato, tuber 

w/peel-babyfood 

Potato 

MBS data Cooked PB 0.011 (Washing/ cooking) 0.0034 RDF #1 0.053 0.87 0.00

Potato, tuber w/o 

peel 

Potato 

MBS data 

Uncooked NB 0.14 (Washing/ peeling) 0.0034 RDF #1 N/A 1 0.00

Cooked: 

Fresh 

Cooked: 

Dried 

Cooked: 

Canned 

Cooked: 

Cured 

PB 

0.0042 

(Washing/ 

peeling/ cooking) 

0.0034 RDF #1 

0.053 0.87 0.00

Cooked: 

Frozen PB 

0.0042 

(Washing/ 

peeling/ cooking) 

0.0028 RDF #4 

Potato, tuber w/o 

peel-babyfood 

Potato 

MBS data 

Cooked: 

Canned PB 

0.0042 

(Washing/ 

peeling/ cooking) 

0.0034 RDF #1 0.053 0.87 0.00
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 19 of 62 

Anticipated Residue Summary for Existing Uses of Metiram 

Commodity Data Source2 DEEM Food Form Blended Classification2

Metiram ETU 

Processing 

Factor 

Anticipated Residue 

(ppm) or RDF3 # EBDC to ETU 

Conversion 

Processing 

Factor 

An

(

Chronic/ 

Cancer Acute Chro

Can

Apple, fruit with 

peel Apple FT 

Uncooked NB 0.41 (Washing) 

0.242 RDF # 2 

N/A 1 0.0

Cooked NB 0.025 (Washing and Cooking) 0.0023 (Cooking) 0.87 (Cooking) 0.00

Apple, peeled 

fruit 

Apple FT Uncooked NB 0.41 (Washing/) 0.242 RDF # 2 N/A 1 0.0

Apple FT 

Cooked, 

Fresh 

Cooked, 

Frozen 

Cooked, 

Dried, 

Cooked, 

Canned 

NB/PB 0.025 (Washing and Cooking) 0.242 RDF # 2 0.0023 (Cooking) 0.87 (Cooking) 0.00

Apple, peeled 

fruit-babyfood Apple FT Cooked, Canned PB 0.025 (Washing and Cooking) 0.242 RDF # 2 0.0023 (Cooking) 0.87 (Cooking) 0.00

Apples-dried Apple FT 

Uncooked B 0.11 (Washing/drying) 

0.242 0.0605 

N/A 1 0.0

Cooked B 

0.0066 

(Washing,drying 

and Cooking) 

0.0023 

(Cooking) 

0.87 

(Cooking) 0.00

Apple, driedbabyfood Apple FT Cooked B 0.0066 (Washing. Drying and Cooking) 0.242 0.0605 0.0023 (Cooking) 0.87 (Cooking) 0.00

Apples-juice Apple FT 

Uncooked PB 0.041 ( Washing and Juicing) 

0.242 RDF # 2 

0.0046 

(Juice) 1 0.00

Cooked PB 

0.0025 (washing, 

Cooking and 

Juicing) 

0.0046 

(Juice) 

0.87 

(Cooking) 0.00

Apples, juicebabyfood Apple FT Cooked PB 

0.0025 

(Washing, 

Cooking and 

Juicing) 

0.242 RDF # 2 0.0046 (Juice) 0.87 (Cooking) 0.00

Apple, sauce Apple FT 

Uncooked NB 0.41 (Washing and Cooking) 0.242 RDF # 2 N/A 1 0.0

Cooked NB 0.025 (Washing and Cooking) 0.0023 (Cooking) 0.87 (Cooking) 0.00
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 20 of 62 

Anticipated Residue Summary for Existing Uses of Metiram 

Commodity Data Source2 DEEM Food Form Blended Classification2

Metiram ETU 

Processing 

Factor 

Anticipated Residue 

(ppm) or RDF3 # EBDC to ETU 

Conversion 

Processing 

Factor 

An

(

Chronic/ 

Cancer Acute Chro

Can

Apple, saucebabyfood Apple FT Cooked, Canned PB 0.025 (Washing and Cooking) 0.242 RDF # 2 0.0023 (Cooking) 0.87 (Cooking) 0.00

 1. FT = Field trial; MBS = EBDC Market Basket Survey  2. PB = Partially blended; B = Blended; NB = Not Blended  3. RDF = Residue Distribution File 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 21 of 62 

Metiram RDF Files – Existing Uses 

PotatoMBS.rdf 

Potato Raw, UNW 

10 %CT 

TotalZ=315 

TotalNZ=7 

28, 0.0025 

0.0054 0.0192 0.0106 0.007 

0.0268 0.005 0.2328 

Apple.rdf 

Metiram - Apples 

25 % CT 

Totalz=69 

Totalnz = 23 

0.1633 0.1081 0.0159 0.015 

0.2095 0.0609 0.2872 0.2365 

0.1971 0.3744 0.0251 0.1036 

0.1391 0.0351 0.5236 0.1265 

0.5126 0.0557 0.437 0.5062 

0.1959 0.1959 1.0504 

Potato 

Potato, Frozen Raw, UNW 

10%CT 

TotalZ=225 

TotalNZ=5 

20, 0.0028 

0.0052 0.0060 0.0055 0.0052 0.0075 

ETU RDF Files – Existing Uses 

AppleuncookedETU.rdf 

Apple - Uncooked -FT 

25% CT 

TOTALZ=69 

TOTALNZ=23 

0.0075 0.0058 0.0030 0.0030 

0.0089 0.0044 0.0113 0.0098 

0.0086 0.0140 0.0033 0.0057 

0.0068 0.0036 0.0224 0.0064 

0.0183 0.0042 0.0159 0.0181 

0.0085 0.0085 0.0443 

ApplecookedETU.rdf 

Apple - Cooked - FT 

25% CT 

TOTALZ=69 

TOTALNZ=23 

0.0029 0.0026 0.0022 0.0022 

 0.003 0.0024 0.0034 0.0032 

0.003 0.0037 0.0023 0.0026 

0.0028 0.0023 0.0077 0.0027 

 0.0043 0.0024 0.004 0.0043 

0.003 0.003 0.0148 

ApplejuiceuncookedETU.rdf 

Apple Juice - UNCOOKED - 

FT 

25% CT 

TOTALZ=69 

TOTALNZ=23 

0.0038 0.0033 0.0026 

0.0026 0.0041 0.0030 

0.0047 0.0043 0.0040 

0.0054 0.0027 0.0033 

0.0036 0.0028 0.0103 

0.0035 0.0064 0.0029 

0.0059 0.0064 0.0040 

0.0040 0.0201 

ApplejuicecookedETU.rdf 

Apple Juice - COOKED - FT 

25% CT 

TOTALZ=69 

TOTALNZ=23 

0.0030 0.0027 0.0023 

0.0022 0.0032 0.0025 

0.0035 0.0033 0.0031 

0.0040 0.0023 0.0027 

0.0028 0.0023 0.0080 

0.0028 0.0046 0.0024 

0.0043 0.0046 0.0031 

0.0031 0.0155 

PotatoETUuncookedMBS.rdf 

Potato- MBS Uncooked 

10% CT 

TOTALZ=0 

TOTALNZ=110 

206, 0.0010 

0.0076 0.0021 0.001 0.0117 0.006 0.0063 0.0041 0.0023 

0.002 0.0128 0.0034 0.0027 0.0022 0.0044 0.0044 0.0058 

0.0054 0.0026 0.0025 0.0106 0.0051 0.0054 0.0088 0.0036 

0.0033 0.0073 0.0047 0.002 0.0054 0.0036 0.0032 0.0029 

0.0022 0.0028 0.0037 0.0026 0.003 0.0024 0.0039 0.0034 

0.002 0.0128 0.0101 0.004 0.002 0.0075 0.0036 0.0045 

0.002 0.002 0.007 0.0022 0.0096 0.0034 0.0072 0.0021 

0.0021 0.0161 0.0044 0.0105 0.004 0.0024 0.0072 0.0084 

0.0062 0.0255 0.0098 0.002 0.0044 0.0088 0.0035 0.0031 

0.0044 0.0104 0.0046 0.0037 0.0055 0.0026 0.0452 0.0036 

0.0037 0.0013 0.008 0.0034 0.0052 0.0058 0.0038 0.0038 

0.0104 0.003 0.0052 0.0328 0.0092 0.002 0.0042 0.0126 

0.0028 0.0107 0.0039 0.0062 0.0105 0.002 0.003 0.0038 

0.0034 0.0026 0.0038 0.0023 0.0058 0.0093 

PotatoETUCookedMBS.rdf 

Potato-MBS cooked 

10% CT 

TOTALZ=0 

TOTALNZ=110 

206, 0.0010 

0.0069 0.0021 0.0020 0.0104 0.0055 0.0057 0.0038 

 0.0023 0.0020 0.0113 0.0032 0.0026 0.0022 0.0047 

 0.0041 0.0053 0.0050 0.0025 0.0024 0.0095 0.0047 

 0.0050 0.0079 0.0034 0.0034 0.0066 0.0044 

0.0020 0.0050 0.0034 0.0031 0.0028 0.0022 .0027 

 0.0035 0.0025 0.0029 0.0024 0.0037 0.0032 0.0020 

0.0114 0.0090 0.0037 0.0020 0.0068 0.0034 0.0042 

 0.0020 0.0020 0.0064 0.0022 0.0086 .0032 0.0065 

 0.0021 0.0021 0.0143 0.0041 0.0094 0.0037 0.0024 

 0.0065 0.0076 0.0057 0.0225 0.0088 0.0011 0.0041 

 0.0079 0.0033 0.0030 0.0041 .0093 0.0043 

0.0035 0.0051 0.0025 0.0396 0.0034 0.0035 0.0023 

0.0072 0.0032 0.0048 0.0053 0.0036 0.0036 0.0093 

 0.0029 0.0048 0.0288 0.0083 .0020 0.0039 0.0112 

 0.0027 0.0096 0.0037 0.0057 0.0094 0.0020 0.0029 

 0.0036 0.0134 0.0025 0.0036 0.0023 0.0053 

0.0084 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 22 of 62 

Attachment 3: Screening Level Usage Analysis for Existing Uses of Metiram 

Tuesday, March 22, 2005 

Screening Level Estimates of Agricultural Uses of Metiram 

Sorted Alphabetically 

 

Crop Lbs. A.I. Percent Crop Ttd. 

 Avg. Max. 

1 Apples 500,000 15 25 

2 Asparagus 1,000 <1 <2.5 

3 Peaches 2,000 <1 <2.5 

4 Pears <500 <1 <2.5 

5 Potatoes 400,000 10 10 

6 Squash <500 <1 <2.5 

 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 23 of 62 

Attachment 4: BEAD Memo on Percent Imported for Bananas and Grapes 

MEMORANDUM

SUBJECT: Projected Percent Crop Treated (PPCT) for Fungicide Mancozeb (PC 14504) on 

Five Crops (DP 330013), and Import Shares for Two Crops (DP 330015) 

FROM: Jihad Alsadek, Ph.D., Economist 

 Science Information & Analysis Branch 

 Biological and Economic Analysis Division (7503P) 

TO: Mary Waller 

 MUIERB 

 Registration Division (7505P) 

I. SUMMARY 

 This memorandum provides average and maximum projected percent crop treated (PPCT) 

numbers for five new mancozeb uses (almonds, broccoli, cabbage, lettuce, and peppers), and 

import shares for grapes and bananas. In addition, it provides the suggested Federal Register 

(FR) language. Tabulated biological justifications/comments in Table 1, provided by Richard 

Michell, plant pathologist with BEAD, give both explanations for these PPCTs as well as 

background for the proposed FR language. The estimated PPCTs and the corresponding 

methodology for the five crops, together with estimated import shares, are given in Table 2. 

BEAD has determined that there are no factors that clearly indicate that the actual PCTs for 

mancozeb on almonds, broccoli, cabbage, lettuce, and peppers in the next five years will exceed 

the estimated PPCT provided for mancozeb on these crops. Below is the recommended 

boilerplate FR language, as well as the tabulated background information on all five crops. This 

memorandum has been reviewed by Alan Halvorson, an economist with BEAD. 

II. FR LANGUAGE 

 

EPA estimates PPCT for a new pesticide use by assuming that the percent crop treated 

(PCT) during the pesticide’s initial five years of use on a specific use site will not exceed the 

average PCT of the market leader (i.e., the one with the greatest PCT) on that site over the three 

most recent surveys. Comparisons are only made among pesticides of the same pesticide types 

[i.e., the dominant fungicide(s) on the use site is selected for comparison with the new 

fungicide(s)]. The PCTs included in the average may be each for the same pesticide or for 

different pesticides since the same or different pesticides may dominate for each year selected. 

Typically, EPA uses USDA/NASS as the source for the PCT data because they are publicly 

available. When a specific use site is not surveyed by USDA/NASS, EPA uses proprietary data 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 24 of 62 

and calculates the estimated PCT. 

This estimated PPCT, based on the average PCT of the market leader, is appropriate for 

use in the chronic dietary risk assessment. This method of estimating a PPCT for a new use of a 

registered pesticide or a new pesticide produces a high-end estimate that is unlikely, in most 

cases, to be exceeded during the initial five years of actual use. The predominant factors that 

generally can be analyzed based on readily available information and that bear on whether the 

PPCT could be exceeded are whether there are concerns with pest pressures as indicated in 

emergency exemption requests or other readily available information, whether the new pesticide 

controls a broader spectrum of pests than the market leader pesticide(s) and/or whether the new 

pesticide has a shorter post-harvest interval (PHI). 

All such relevant information currently available has been considered for mancozeb on almonds, 

broccoli, cabbage, lettuce, and peppers, and it is unlikely that actual PCT for mancozeb will 

exceed the estimated PPCT for mancozeb on each of these five crops during the next five years 

mainly because mancozeb and its counterpart maneb have both been registered on a wide range 

of crops for many years and are considered to have comparable pest spectra and efficacy. 

Accordingly, based on maneb’s labeled pests, mancozeb may also provide control of almond 

scab, almond anthracnose, almond leaf rust, and lettuce anthracnose, downy mildew of cabbage 

and broccoli, and bacterial spot and cercospora leaf spot of peppers. If mancozeb is used for any 

of these non-labeled pests it would still be competing for market share with maneb and possibly 

other fungicides. 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 25 of 62 

TABLE 1 

CURSORY BIOLOGICAL ANALYSIS OF BEAD’S PROJECTED PERCENT CROP 

TREATED (PPCT) FOR MANCOZEB ON FIVE NEW CROPS 

NEW USES 

[AVG. /MAX. 

PPCT] 

RECENT MARKET 

LEADER(S) 

[SAMPLE YEARS] 

JUSTIFICATION/COMMENTS WILL 

MANCOZEB 

EXCEED 

THE PPCT 

LEVELS OF 

RECENT 

MARKET 

LEADER(S)?

ALMONDS – 

SHOTHOLE, 

BROWN ROT 

[35/35] 

IPRODIONE 

[1999] 

iprodione and some of the other 

alternatives reportedly possess 

equal or better efficacy than 

mancozeb’s counterpart maneb, 

which has a much lower pct than 

iprodione 

NO 

 

BROCCOLI - 

ALTERNARIA 

[7/9] 

MEFANOXAM 

[2000, 2002, 2004] 

mefanoxam does not control the 

target pest (alternaria), but is used 

principally for control of downy 

mildew, which is a more prevalent 

pest problem than alternaria; 

mancozeb is expected to split the 

market with its counterpart maneb, 

which had less usage than the 

market leaders 

NO 

CHLOROTHALONIL 

[2000, 2002, 2004] 

chlorothalonil is used to control 

the target pest (alternaria) plus 

downy mildew, which is a more 

prevalent pest problem than 

alternaria; mancozeb is expected 

to split the market with its 

counterpart maneb, which had 

less usage than the market leaders 

 

CABBAGE - 

ALTERNARIA 

[42/47-FRESH; 

10/18-

PROCESSED] 

CHLOROTHALONIL 

[FRESH:2000, 2002, 

2004; PROCESSED: 

1996, 1998, 2000] 

chlorothalonil is used for control 

of the target pest (alternaria) plus 

downy mildew, which is a more 

prevalent pest problem than 

alternaria; mancozeb is expected 

to split the market with its 

counterpart maneb, which had 

less usage than the market leader 

NO 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 26 of 62 

NEW USES 

[AVG. /MAX. 

PPCT] 

RECENT MARKET 

LEADER(S) 

[SAMPLE YEARS] 

JUSTIFICATION/COMMENTS WILL 

MANCOZEB 

EXCEED 

THE PPCT 

LEVELS OF 

RECENT 

MARKET 

LEADER(S)?

 

LETTUCE – 

DOWNY 

MILDEW 

[58/66] 

MANEB 

[2000, 2002, 2004] 

maneb is used for anthracnose and 

downy mildew; mancozeb is 

expected to split the market with 

its counterpart maneb, which has 

been a market leader in recent 

years 

NO 

FOSETYL-AL 

[2000, 2002, 2004] 

fosetyl-al is used principally for 

downy mildew control, however, it 

is primarily used as an alternative 

to maneb, especially just before 

harvest because it has a much 

lower PHI and can be applied 

closer to harvest than maneb; 

mancozeb will have a PHI 

limitation similar to maneb; 

accordingly, mancozeb is only 

expected to gain a portion of the 

maneb market. 

 

PEPPERS – 

ANTHRACNOSE, 

EARLY BLIGHT, 

PHOMOPSIS 

[43/48] 

SULFUR 

[2000, 2002, 2004] 

Sulfur is applied principally for 

control of powdery mildew; while 

mancozeb’s counterpart maneb is 

used for control of frogeye leaf 

spot, anthracnose & bacterial 

diseases; mancozeb will only be 

competing for a portion of 

maneb’s market share. 

NO 

COPPER 

HYDROXIDE 

[2000, 2002, 2004] 

Copper is applied principally for 

control of frogeye leaf spot & 

bacterial diseases; for bacterial 

diseases it is often used in tankmixes with mancozeb’s 

counterpart maneb to enhance 

copper efficacy; current maneb use 

is for control of frogeye leaf spot, 

anthracnose & bacterial diseases; 

mancozeb will only be competing 

for a portion of maneb’s market 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 27 of 62 

NEW USES 

[AVG. /MAX. 

PPCT] 

RECENT MARKET 

LEADER(S) 

[SAMPLE YEARS] 

JUSTIFICATION/COMMENTS WILL 

MANCOZEB 

EXCEED 

THE PPCT 

LEVELS OF 

RECENT 

MARKET 

LEADER(S)?

share. 

ASSUMPTIONS: mancozeb and its counterpart maneb have both been registered on a wide 

range of crops for many years and are considered to have comparable pest spectra and efficacy. 

Accordingly, based on maneb’s labeled pests, mancozeb may also provide control of almond 

scab, almond anthracnose, almond leaf rust, and lettuce anthracnose, downy mildew of cabbage 

and broccoli, and bacterial spot and cercospora leaf spot of peppers. If mancozeb is used for any 

of these non-labeled pests it would still be competing for market share with maneb and possibly 

other fungicides. 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 28 of 62 

Table 2 

Mancozeb Projected Percent Crop treated (PPCT) 

Crop Alternative1 

Chemical (s) 

Average2 

Market 

Leader 

Maximum3 

Market 

Leader 

Years 

Almonds Iprodione 35 35 1999 

Broccoli Mefenoxam, 

Chlorothaloni

l

7 9 2000, 2002, 

2004 

CabbageFresh 

Chlorothaloni

l 

42 47 2000, 2002, 

2004 

CabbageProcessed 

Chlorothaloni

l 

10 18 1996, 1998, 

2000 

LettuceHead 

Maneb 58 66 2000, 2002, 

2004 

LettuceOther 

Maneb, 

Fosetyl-Al 

59 61 2000, 2002, 

2004 

Peppers-Bell Sulfur, 

Copper 

Hydroxide 

43 48 2000, 2002, 

2004 

Sources: 

Agricultural Chemical Usage, Vegetables Summary (2000, 2002, and 2004). Agricultural Statistics Board 

NASS, USDA. 

Agricultural Chemical Usage, Fruits and Nuts Summary (1999). Agricultural Statistics Board 

NASS, USDA. 

Import Shares4 for Grapes and Bananas 

Crop Import 

Share5 

Grapes 44 

Bananas6 99 

Sources: 

1. U.S. Department of Agriculture and the Census Bureau of the U.S. Department of Commerce.

2. Economic Research Service (ERS), USDA, FAU – 79 – 01, July 2003.

 

1 Alternative chemical could be the same chemical for all three years or could be different for each year. 

2 Average of the available years. 

3 The highest observed percent crop treated. 

4 Import share is an average of three years (1999, 2000, and 2001). 

5 This is the import share of food consumption. 

6 Bananas have 100 or close to 100 percent import shares and was excluded from the list of import share table in 

ERS. 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 29 of 62 

Attachment 5: Residue Input File – Metiram Acute Analysis – Food Only 

Filename: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM 

Files\Metiram\MetiramAcutePriasept2006.R98 

Chemical: Metiram 

RfD(Chronic): .0004 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day 

RfD(Acute): .01 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day 

Date created/last modified: 09-27-2006/14:12:41/8 Program ver. 2.03 

Comment: Females 13+ only 

-------------------------------------------------------------------------------- 

RDL indices and parameters for Monte Carlo Analysis: 

Index Dist Parameter #1 Param #2 Param #3 Comment 

 # Code 

----- ---- ------------ -------- -------- ------- 

 1 6 potatoMBS.rdf 

 2 6 apple.rdf 

 3 6 bananas.rdf 

 4 6 potato frozen MBS.rdf 

 5 6 GRAPES.RDF 

 6 6 WINEGRAPES.RDF 

 EPA Crop Commodity Name Def Res Adj.Factors RDL Comment 

 Code Grp (ppm) #1 #2 Pntr 

-------- ---- ------------------------------- ---------- ------ ------ --- ------- 

11000070 11 Apple, fruit with peel 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.410 1.000 2 washin 

 Full comment: washing factor 

 150-Uncooked; Cured etc; Cook Meth N/S 

 1.000000 0.410 1.000 2 washin 

 Full comment: washing factor 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 0.025 1.000 2 washin 

 Full comment: washing/cooking 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 0.025 1.000 2 washin 

 Full comment: washing/cooking 

11000080 11 Apple, peeled fruit 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.410 1.000 2 washin 

 Full comment: washing/peeling 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.025 1.000 2 washin 

 Full comment: washing/peeling/cooking 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 0.025 1.000 2 washin 

 Full comment: washing/peeling/cooking 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 0.025 1.000 2 washin 

 Full comment: washing/peeling/cooking 

 221-Cooked; Frozen; Baked 1.000000 0.025 1.000 2 washin 

 Full comment: washing/peeling/cooking 

 232-Cooked; Dried; Boiled 1.000000 0.025 1.000 2 washin 

 Full comment: washing/peeling/cooking 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.025 1.000 2 washin 

 Full comment: washing/peeling/cooking 

11000081 11 Apple, peeled fruit-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.025 1.000 2 washin 

 Full comment: washing/peeling/cooking 

11000090 11 Apple, dried 

 130-Uncooked; Dried; Cook Meth N/S 

 0.060500 0.110 1.000 drying 

 Full comment: drying factor 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.060500 0.007 1.000 drying 

 Full comment: drying factor 

 211-Cooked; Fresh or N/S; Baked 

 0.060500 0.007 1.000 drying 

 Full comment: drying factor 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 30 of 62 

 230-Cooked; Dried; Cook Meth N/S 

 0.060500 0.007 1.000 drying 

 Full comment: drying factor 

11000091 11 Apple, dried-babyfood 

 230-Cooked; Dried; Cook Meth N/S 

 0.060500 0.007 1.000 drying 

 Full comment: drying factor 

11000100 11 Apple, juice 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.041 1.000 2 juicin 

 Full comment: juicing factor 

 120-Uncooked; Frozen; Cook Meth N/S 

 1.000000 0.041 1.000 2 juicin 

 Full comment: juicing factor 

 130-Uncooked; Dried; Cook Meth N/S 

 1.000000 0.041 1.000 2 juicin 

 Full comment: juicing factor 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.003 1.000 2 juicin 

 Full comment: juicing factor 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 0.003 1.000 2 juicin 

 Full comment: juicing factor 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 0.003 1.000 2 juicin 

 Full comment: juicing factor 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 0.003 1.000 2 juicin 

 Full comment: juicing factor 

 214-Cooked; Fresh or N/S; Fried/baked 

 1.000000 0.003 1.000 2 juicin 

 Full comment: juicing factor 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 0.003 1.000 2 juicin 

 Full comment: juicing factor 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.003 1.000 2 juicin 

 Full comment: juicing factor 

11000101 11 Apple, juice-babyfood 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 0.003 1.000 2 juicin 

 Full comment: juicing factor 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.003 1.000 2 juicin 

 Full comment: juicing factor 

11000110 11 Apple, sauce 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.410 1.000 2 sauce 

 Full comment: sauce factor 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.025 1.000 2 sauce 

 Full comment: sauce factor 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 0.025 1.000 2 sauce 

 Full comment: sauce factor 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 0.025 1.000 2 sauce 

 Full comment: sauce factor 

 221-Cooked; Frozen; Baked 1.000000 0.025 1.000 2 sauce 

 Full comment: sauce factor 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.025 1.000 2 sauce 

 Full comment: sauce factor 

11000111 11 Apple, sauce-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.025 1.000 2 sauce 

 Full comment: sauce factor 

95000230 O Banana 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 3 

 120-Uncooked; Frozen; Cook Meth N/S 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 31 of 62 

 1.000000 1.000 1.000 3 

 130-Uncooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 3 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 0.060 1.000 3 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 0.060 1.000 3 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 0.060 1.000 3 

 223-Cooked; Frozen; Fried 1.000000 0.060 1.000 3 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.060 1.000 3 

95000231 O Banana-babyfood 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 0.060 1.000 3 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 0.060 1.000 3 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.060 1.000 3 

95000240 O Banana, dried 

 130-Uncooked; Dried; Cook Meth N/S 

 0.050000 0.016 1.000 

 211-Cooked; Fresh or N/S; Baked 

 0.050000 0.016 1.000 

 230-Cooked; Dried; Cook Meth N/S 

 0.050000 0.016 1.000 

95000241 O Banana, dried-babyfood 

 230-Cooked; Dried; Cook Meth N/S 

 0.050000 0.016 1.000 

95001750 O Grape 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.120 1.000 5 

 120-Uncooked; Frozen; Cook Meth N/S 

 1.000000 0.120 1.000 5 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.007 1.000 5 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.007 1.000 5 

95001760 O Grape, juice 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.100 1.000 5 

 120-Uncooked; Frozen; Cook Meth N/S 

 1.000000 0.100 1.000 5 

 130-Uncooked; Dried; Cook Meth N/S 

 1.000000 0.100 1.000 5 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.006 1.000 5 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 0.006 1.000 5 

 221-Cooked; Frozen; Baked 1.000000 0.006 1.000 5 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 0.006 1.000 5 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.006 1.000 5 

95001761 O Grape, juice-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.006 1.000 5 

95001770 O Grape, leaves 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.007 1.000 5 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 0.007 1.000 5 

95001780 O Grape, raisin 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.396 1.000 5 

 130-Uncooked; Dried; Cook Meth N/S 

 1.000000 0.396 1.000 5 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.024 1.000 5 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 0.024 1.000 5 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 32 of 62 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 0.024 1.000 5 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 0.024 1.000 5 

 221-Cooked; Frozen; Baked 1.000000 0.024 1.000 5 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 0.024 1.000 5 

 232-Cooked; Dried; Boiled 1.000000 0.024 1.000 5 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.024 1.000 5 

95001790 O Grape, wine and sherry 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.100 1.000 6 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.006 1.000 6 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 0.006 1.000 6 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 0.006 1.000 6 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 0.006 1.000 6 

 221-Cooked; Frozen; Baked 1.000000 0.006 1.000 6 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 0.006 1.000 6 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.006 1.000 6 

 242-Cooked; Canned; Boiled 1.000000 0.006 1.000 6 

 250-Cooked; Cured etc; Cook Meth N/S 

 1.000000 0.006 1.000 6 

01032960 1C Potato, chips 

 211-Cooked; Fresh or N/S; Baked 

 0.000340 0.045 1.000 chips 

 Full comment: chips factor 

 213-Cooked; Fresh or N/S; Fried 

 0.000340 0.045 1.000 chips 

 Full comment: chips factor 

01032970 1C Potato, dry (granules/ flakes) 

 211-Cooked; Fresh or N/S; Baked 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 212-Cooked; Fresh or N/S; Boiled 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 213-Cooked; Fresh or N/S; Fried 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 214-Cooked; Fresh or N/S; Fried/baked 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 221-Cooked; Frozen; Baked 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 230-Cooked; Dried; Cook Meth N/S 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 232-Cooked; Dried; Boiled 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

01032971 1C Potato, dry (granules/ flakes)-b 

 240-Cooked; Canned; Cook Meth N/S 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

01032980 1C Potato, flour 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.000340 3.400 1.000 flakes 

 Full comment: flakes factor 

 120-Uncooked; Frozen; Cook Meth N/S 

 0.000340 3.400 1.000 flakes 

 Full comment: flakes factor 

 130-Uncooked; Dried; Cook Meth N/S 

 0.000340 3.400 1.000 flakes 

 Full comment: flakes factor 

 210-Cooked; Fresh or N/S; Cook Meth N/S 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 33 of 62 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 211-Cooked; Fresh or N/S; Baked 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 212-Cooked; Fresh or N/S; Boiled 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 213-Cooked; Fresh or N/S; Fried 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 214-Cooked; Fresh or N/S; Fried/baked 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 215-Cooked; Fresh or N/S; Boiled/baked 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 220-Cooked; Frozen; Cook Meth N/S 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 221-Cooked; Frozen; Baked 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 222-Cooked; Frozen; Boiled 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 223-Cooked; Frozen; Fried 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 230-Cooked; Dried; Cook Meth N/S 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 231-Cooked; Dried; Baked 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 232-Cooked; Dried; Boiled 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 233-Cooked; Dried; Fried 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 240-Cooked; Canned; Cook Meth N/S 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 242-Cooked; Canned; Boiled 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 250-Cooked; Cured etc; Cook Meth N/S 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 251-Cooked; Cured etc; Baked 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 252-Cooked; Cured etc; Boiled 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

 253-Cooked; Cured etc; Fried 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

01032981 1C Potato, flour-babyfood 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.000340 3.400 1.000 flakes 

 Full comment: flakes factor 

 130-Uncooked; Dried; Cook Meth N/S 

 0.000340 3.400 1.000 flakes 

 Full comment: flakes factor 

 240-Cooked; Canned; Cook Meth N/S 

 0.000340 0.102 1.000 flakes 

 Full comment: flakes factor 

01032990 1C Potato, tuber, w/peel 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.011 1.000 1 washin 

 Full comment: washing/cooking 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 0.011 1.000 1 washin 

 Full comment: washing/cooking 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 0.011 1.000 1 washin 

 Full comment: washing/cooking 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 0.011 1.000 1 washin 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 34 of 62 

 Full comment: washing/cooking 

01032991 1C Potato, tuber, w/peel-babyfood 1.000000 0.011 1.000 1 washin 

 Full comment: washing/cooking 

01033000 1C Potato, tuber, w/o peel 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.140 1.000 1 washin 

 Full comment: washing/peeling 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 0.004 1.000 1 washin 

 Full comment: washing/peeling/cooking 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 0.004 1.000 1 washin 

 Full comment: washing/peeling/cooking 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 0.004 1.000 1 washin 

 Full comment: washing/peeling/cooking 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 0.004 1.000 1 washin 

 Full comment: washing/peeling/cooking 

 221-Cooked; Frozen; Baked 1.000000 0.004 1.000 4 washin 

 Full comment: washing/peeling/cooking 

 223-Cooked; Frozen; Fried 1.000000 0.004 1.000 4 washin 

 Full comment: washing/peeling/cooking 

 232-Cooked; Dried; Boiled 1.000000 0.004 1.000 1 washin 

 Full comment: washing/peeling/cooking 

 233-Cooked; Dried; Fried 1.000000 0.004 1.000 1 washin 

 Full comment: washing/peeling/cooking 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.004 1.000 1 washin 

 Full comment: washing/peeling/cooking 

 242-Cooked; Canned; Boiled 1.000000 0.004 1.000 1 washin 

 Full comment: washing/peeling/cooking 

 252-Cooked; Cured etc; Boiled 1.000000 0.004 1.000 1 washin 

 Full comment: washing/peeling/cooking 

 253-Cooked; Cured etc; Fried 1.000000 0.004 1.000 1 washin 

 Full comment: washing/peeling/cooking 

01033001 1C Potato, tuber, w/o peel-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 0.004 1.000 1 washin 

 Full comment: washing/peeling/cooking
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 35 of 62 

Attachment 7: Results File – Metiram Acute Analysis – Food Only 

 U.S. Environmental Protection Agency Ver. 2.02 

DEEM-FCID ACUTE Analysis for METIRAM (1994-98 data) 

Residue file: MetiramAcutePriasept2006.R98 Adjustment factor #2 used. 

Analysis Date: 03-06-2007/15:08:14 Residue file dated: 03-06-2007/15:06:38/8 

Daily totals for food and foodform consumption used. 

MC iterations = 1000 MC list in residue file MC seed = 10 

Run Comment: "Females 13+ only" 

=============================================================================== 

Summary calculations (per capita): 

 95th Percentile 99th Percentile 99.9th Percentile 

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- -------- 

Females 13-49 yrs: 

 0.000169 1.69 0.000654 6.54 0.001926 19.26 

 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 36 of 62 

Attachment 8: Results File Metiram Chronic Analysis – Food Only 

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for METIRAM (1994-98 data) 

Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM 

Files\Metiram\MetiramChronicpriasept2006.R98 

 Adjustment factor #2 used. 

Analysis Date 09-27-2006/14:19:03 Residue file dated: 09-27-2006/14:18:14/8 

Reference dose (RfD, Chronic) = .0004 mg/kg bw/day 

COMMENT 1: Females 13+ only 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- --------------- 

U.S. Population (total) 0.000048 12.0% 

U.S. Population (spring season) 0.000046 11.5% 

U.S. Population (summer season) 0.000050 12.4% 

U.S. Population (autumn season) 0.000047 11.8% 

U.S. Population (winter season) 0.000050 12.4% 

Northeast region 0.000053 13.3% 

Midwest region 0.000047 11.7% 

Southern region 0.000041 10.2% 

Western region 0.000057 14.2% 

Hispanics 0.000052 12.9% 

Non-hispanic whites 0.000049 12.3% 

Non-hispanic blacks 0.000038 9.4% 

Non-hisp/non-white/non-black 0.000049 12.3% 

All infants (< 1 year) 0.000052 13.0% 

Nursing infants 0.000039 9.7% 

Non-nursing infants 0.000057 14.2% 

Children 1-6 yrs 0.000189 47.3% 

Children 7-12 yrs 0.000059 14.7% 

Females 13-19 (not preg or nursing) 0.000025 6.2% 

Females 20+ (not preg or nursing) 0.000034 8.6% 

Females 13-50 yrs 0.000034 8.5% 

Females 13+ (preg/not nursing) 0.000034 8.4% 

Females 13+ (nursing) 0.000044 11.0% 

Males 13-19 yrs 0.000018 4.6% 

Males 20+ yrs 0.000028 7.1% 

Seniors 55+ 0.000040 9.9% 

Children 1-2 yrs 0.000281 70.3% 

Children 3-5 yrs 0.000163 40.7% 

Children 6-12 yrs 0.000063 15.7% 

Youth 13-19 yrs 0.000022 5.4% 

Adults 20-49 yrs 0.000028 6.9% 

Adults 50+ yrs 0.000039 9.7% 

Females 13-49 yrs 0.000030 7.4% 

------------------------------------------------------------------------------- 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 37 of 62 

Attachment 9: Residue Input File – ETU Acute Analysis – Food Only 

Filename: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM 

Files\Metiram\ETUAcutemetiramPRIAsept2006foodonly.R98 

Chemical: ETU 

RfD(Chronic): .0002 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day 

RfD(Acute): .005 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0601 

Date created/last modified: 09-27-2006/14:29:18/8 Program ver. 2.03 

Comment: Females 13+ only 

-------------------------------------------------------------------------------- 

RDL indices and parameters for Monte Carlo Analysis: 

Index Dist Parameter #1 Param #2 Param #3 Comment 

 # Code 

----- ---- ------------ -------- -------- ------- 

 1 6 appleuncookedETU.rdf 

 2 6 applecookedETU.rdf 

 3 6 applejuiceuncookedETU.rdf 

 4 6 applejuicecookedETU.rdf 

 5 6 PotatoETUuncookedMBS.rdf 

 6 6 PotatoETUCookedMBS.rdf 

 7 6 ETUuncookedbananas.rdf 

 8 6 ETUcookedbananas.rdf 

 9 6 ETUuncookedgrapes.rdf 

 10 6 ETUcookedgrapes.rdf 

 11 6 ETUuncookedraisins.rdf 

 12 6 ETUcookedraisins.rdf 

 13 6 ETUuncookedwine.rdf 

 14 6 ETUcookedwine.rdf 

 15 6 ETUuncookedgrapejuice.rdf 

 16 6 ETUcookedgrapejuice.rdf 

 EPA Crop Commodity Name Def Res Adj.Factors RDL Comment 

 Code Grp (ppm) #1 #2 Pntr 

-------- ---- ------------------------------- ---------- ------ ------ --- ------- 

11000070 11 Apple, fruit with peel 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 1 washin 

 Full comment: washing factor 

 150-Uncooked; Cured etc; Cook Meth N/S 

 1.000000 1.000 1.000 1 washin 

 Full comment: washing factor 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 2 washin 

 Full comment: washing factor 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 2 washin 

 Full comment: washing factor 

11000080 11 Apple, peeled fruit 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 1 peelin 

 Full comment: peeling factor 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 2 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 2 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 2 

 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 2 

 232-Cooked; Dried; Boiled 1.000000 1.000 1.000 2 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 2 

11000081 11 Apple, peeled fruit-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 2 

11000090 11 Apple, dried 

 130-Uncooked; Dried; Cook Meth N/S 

 0.002600 1.000 1.000 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.000900 1.000 1.000 

 211-Cooked; Fresh or N/S; Baked 

 0.000900 1.000 1.000 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 38 of 62 

 230-Cooked; Dried; Cook Meth N/S 

 0.000900 1.000 1.000 

11000091 11 Apple, dried-babyfood 

 230-Cooked; Dried; Cook Meth N/S 

 0.000900 1.000 1.000 

11000100 11 Apple, juice 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 3 

 120-Uncooked; Frozen; Cook Meth N/S 

 1.000000 1.000 1.000 3 

 130-Uncooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 3 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 4 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 4 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 1.000 1.000 4 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 4 

 214-Cooked; Fresh or N/S; Fried/baked 

 1.000000 1.000 1.000 4 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 4 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 4 juicin 

 Full comment: juicing factor 

11000101 11 Apple, juice-babyfood 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 4 juicin 

 Full comment: juicing factor 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 4 juicin 

 Full comment: juicing factor 

11000110 11 Apple, sauce 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 3 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 2 Cookin 

 Full comment: Cooking factor 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 2 Cookin 

 Full comment: Cooking factor 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 1.000 1.000 2 Cookin 

 Full comment: Cooking factor 

 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 2 Cookin 

 Full comment: Cooking factor 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 2 Cookin 

 Full comment: Cooking factor 

11000111 11 Apple, sauce-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 2 

95000230 O Banana 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 7 

 120-Uncooked; Frozen; Cook Meth N/S 

 1.000000 1.000 1.000 7 

 130-Uncooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 7 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 8 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 1.000 1.000 8 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 8 

 223-Cooked; Frozen; Fried 1.000000 1.000 1.000 8 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 8 

95000231 O Banana-babyfood 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 39 of 62 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 8 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 8 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 8 

95000240 O Banana, dried 

 130-Uncooked; Dried; Cook Meth N/S 

 0.282000 1.000 1.000 

 211-Cooked; Fresh or N/S; Baked 

 0.023600 1.000 1.000 

 230-Cooked; Dried; Cook Meth N/S 

 0.023600 1.000 1.000 

95000241 O Banana, dried-babyfood 

 230-Cooked; Dried; Cook Meth N/S 

 0.023600 1.000 1.000 

95001750 O Grape 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 9 

 120-Uncooked; Frozen; Cook Meth N/S 

 1.000000 1.000 1.000 9 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 10 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 10 

95001760 O Grape, juice 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 15 

 120-Uncooked; Frozen; Cook Meth N/S 

 1.000000 1.000 1.000 15 

 130-Uncooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 15 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 16 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 16 

 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 16 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 16 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 16 

95001761 O Grape, juice-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 16 

95001770 O Grape, leaves 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 10 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 10 

95001780 O Grape, raisin 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 11 

 130-Uncooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 11 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 12 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 12 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 1.000 1.000 12 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 12 

 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 12 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 12 

 232-Cooked; Dried; Boiled 1.000000 1.000 1.000 12 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 12 

95001790 O Grape, wine and sherry 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 14 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 40 of 62 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 14 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 14 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 1.000 1.000 14 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 14 

 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 14 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 14 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 14 

 242-Cooked; Canned; Boiled 1.000000 1.000 1.000 14 

 250-Cooked; Cured etc; Cook Meth N/S 

 1.000000 1.000 1.000 14 

01032960 1C Potato, chips 

 211-Cooked; Fresh or N/S; Baked 

 0.000310 1.000 1.000 cookin 

 Full comment: cooking factor 

 213-Cooked; Fresh or N/S; Fried 

 0.000310 1.000 1.000 cookin 

 Full comment: cooking factor 

01032970 1C Potato, dry (granules/ flakes) 

 211-Cooked; Fresh or N/S; Baked 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 212-Cooked; Fresh or N/S; Boiled 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 213-Cooked; Fresh or N/S; Fried 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 214-Cooked; Fresh or N/S; Fried/baked 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 221-Cooked; Frozen; Baked 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 230-Cooked; Dried; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 232-Cooked; Dried; Boiled 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

01032971 1C Potato, dry (granules/ flakes)-b 

 240-Cooked; Canned; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

01032980 1C Potato, flour 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.000986 1.000 1.000 

 120-Uncooked; Frozen; Cook Meth N/S 

 0.000986 1.000 1.000 

 130-Uncooked; Dried; Cook Meth N/S 

 0.000986 1.000 1.000 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 211-Cooked; Fresh or N/S; Baked 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 212-Cooked; Fresh or N/S; Boiled 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 213-Cooked; Fresh or N/S; Fried 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 214-Cooked; Fresh or N/S; Fried/baked 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 215-Cooked; Fresh or N/S; Boiled/baked 

 0.000867 1.000 1.000 cookin 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 41 of 62 

 Full comment: cooking factor 

 220-Cooked; Frozen; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 221-Cooked; Frozen; Baked 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 222-Cooked; Frozen; Boiled 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 223-Cooked; Frozen; Fried 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 230-Cooked; Dried; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 231-Cooked; Dried; Baked 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 232-Cooked; Dried; Boiled 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 233-Cooked; Dried; Fried 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 240-Cooked; Canned; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 242-Cooked; Canned; Boiled 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 250-Cooked; Cured etc; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 251-Cooked; Cured etc; Baked 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 252-Cooked; Cured etc; Boiled 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 253-Cooked; Cured etc; Fried 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

01032981 1C Potato, flour-babyfood 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.000986 1.000 1.000 

 130-Uncooked; Dried; Cook Meth N/S 

 0.000986 1.000 1.000 

 240-Cooked; Canned; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

01032990 1C Potato, tuber, w/peel 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

01032991 1C Potato, tuber, w/peel-babyfood 1.000000 1.000 1.000 6 

01033000 1C Potato, tuber, w/o peel 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 5 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 6 cookin 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 42 of 62 

 Full comment: cooking factor 

 223-Cooked; Frozen; Fried 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 232-Cooked; Dried; Boiled 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 233-Cooked; Dried; Fried 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 242-Cooked; Canned; Boiled 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 252-Cooked; Cured etc; Boiled 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 253-Cooked; Cured etc; Fried 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

01033001 1C Potato, tuber, w/o peel-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 43 of 62 

Attachment 10: Residue Input File – ETU Acute Analysis – Food and Water 

Filename: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM 

Files\Metiram\ETUAcutemetiramPRIAsept2006foodand water.R98 

Chemical: ETU 

RfD(Chronic): .0002 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day 

RfD(Acute): .005 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0601 

Date created/last modified: 09-27-2006/14:32:56/8 Program ver. 2.03 

Comment: Females 13+ only food plus water 

-------------------------------------------------------------------------------- 

RDL indices and parameters for Monte Carlo Analysis: 

Index Dist Parameter #1 Param #2 Param #3 Comment 

 # Code 

----- ---- ------------ -------- -------- ------- 

 1 6 appleuncookedETU.rdf 

 2 6 applecookedETU.rdf 

 3 6 applejuiceuncookedETU.rdf 

 4 6 applejuicecookedETU.rdf 

 5 6 PotatoETUuncookedMBS.rdf 

 6 6 PotatoETUCookedMBS.rdf 

 7 6 ETUuncookedbananas.rdf 

 8 6 ETUcookedbananas.rdf 

 9 6 ETUuncookedgrapes.rdf 

 10 6 ETUcookedgrapes.rdf 

 11 6 ETUuncookedraisins.rdf 

 12 6 ETUcookedraisins.rdf 

 13 6 ETUuncookedwine.rdf 

 14 6 ETUcookedwine.rdf 

 15 6 ETUuncookedgrapejuice.rdf 

 16 6 ETUcookedgrapejuice.rdf 

 EPA Crop Commodity Name Def Res Adj.Factors RDL Comment 

 Code Grp (ppm) #1 #2 Pntr 

-------- ---- ------------------------------- ---------- ------ ------ --- ------- 

11000070 11 Apple, fruit with peel 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 1 washin 

 Full comment: washing factor 

 150-Uncooked; Cured etc; Cook Meth N/S 

 1.000000 1.000 1.000 1 washin 

 Full comment: washing factor 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 2 washin 

 Full comment: washing factor 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 2 washin 

 Full comment: washing factor 

11000080 11 Apple, peeled fruit 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 1 peelin 

 Full comment: peeling factor 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 2 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 2 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 2 

 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 2 

 232-Cooked; Dried; Boiled 1.000000 1.000 1.000 2 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 2 

11000081 11 Apple, peeled fruit-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 2 

11000090 11 Apple, dried 

 130-Uncooked; Dried; Cook Meth N/S 

 0.002600 1.000 1.000 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.000900 1.000 1.000 

 211-Cooked; Fresh or N/S; Baked 

 0.000900 1.000 1.000 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 44 of 62 

 230-Cooked; Dried; Cook Meth N/S 

 0.000900 1.000 1.000 

11000091 11 Apple, dried-babyfood 

 230-Cooked; Dried; Cook Meth N/S 

 0.000900 1.000 1.000 

11000100 11 Apple, juice 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 3 

 120-Uncooked; Frozen; Cook Meth N/S 

 1.000000 1.000 1.000 3 

 130-Uncooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 3 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 4 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 4 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 1.000 1.000 4 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 4 

 214-Cooked; Fresh or N/S; Fried/baked 

 1.000000 1.000 1.000 4 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 4 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 4 juicin 

 Full comment: juicing factor 

11000101 11 Apple, juice-babyfood 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 4 juicin 

 Full comment: juicing factor 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 4 juicin 

 Full comment: juicing factor 

11000110 11 Apple, sauce 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 3 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 2 Cookin 

 Full comment: Cooking factor 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 2 Cookin 

 Full comment: Cooking factor 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 1.000 1.000 2 Cookin 

 Full comment: Cooking factor 

 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 2 Cookin 

 Full comment: Cooking factor 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 2 Cookin 

 Full comment: Cooking factor 

11000111 11 Apple, sauce-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 2 

95000230 O Banana 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 7 

 120-Uncooked; Frozen; Cook Meth N/S 

 1.000000 1.000 1.000 7 

 130-Uncooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 7 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 8 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 1.000 1.000 8 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 8 

 223-Cooked; Frozen; Fried 1.000000 1.000 1.000 8 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 8 

95000231 O Banana-babyfood 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 45 of 62 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 8 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 8 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 8 

95000240 O Banana, dried 

 130-Uncooked; Dried; Cook Meth N/S 

 0.282000 1.000 1.000 

 211-Cooked; Fresh or N/S; Baked 

 0.023600 1.000 1.000 

 230-Cooked; Dried; Cook Meth N/S 

 0.023600 1.000 1.000 

95000241 O Banana, dried-babyfood 

 230-Cooked; Dried; Cook Meth N/S 

 0.023600 1.000 1.000 

95001750 O Grape 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 9 

 120-Uncooked; Frozen; Cook Meth N/S 

 1.000000 1.000 1.000 9 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 10 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 10 

95001760 O Grape, juice 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 15 

 120-Uncooked; Frozen; Cook Meth N/S 

 1.000000 1.000 1.000 15 

 130-Uncooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 15 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 16 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 16 

 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 16 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 16 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 16 

95001761 O Grape, juice-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 16 

95001770 O Grape, leaves 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 10 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 10 

95001780 O Grape, raisin 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 11 

 130-Uncooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 11 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 12 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 12 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 1.000 1.000 12 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 12 

 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 12 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 12 

 232-Cooked; Dried; Boiled 1.000000 1.000 1.000 12 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 12 

95001790 O Grape, wine and sherry 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 14 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 46 of 62 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 14 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 14 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 1.000 1.000 14 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 14 

 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 14 

 230-Cooked; Dried; Cook Meth N/S 

 1.000000 1.000 1.000 14 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 14 

 242-Cooked; Canned; Boiled 1.000000 1.000 1.000 14 

 250-Cooked; Cured etc; Cook Meth N/S 

 1.000000 1.000 1.000 14 

01032960 1C Potato, chips 

 211-Cooked; Fresh or N/S; Baked 

 0.000310 1.000 1.000 cookin 

 Full comment: cooking factor 

 213-Cooked; Fresh or N/S; Fried 

 0.000310 1.000 1.000 cookin 

 Full comment: cooking factor 

01032970 1C Potato, dry (granules/ flakes) 

 211-Cooked; Fresh or N/S; Baked 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 212-Cooked; Fresh or N/S; Boiled 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 213-Cooked; Fresh or N/S; Fried 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 214-Cooked; Fresh or N/S; Fried/baked 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 221-Cooked; Frozen; Baked 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 230-Cooked; Dried; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 232-Cooked; Dried; Boiled 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

01032971 1C Potato, dry (granules/ flakes)-b 

 240-Cooked; Canned; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

01032980 1C Potato, flour 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.000986 1.000 1.000 

 120-Uncooked; Frozen; Cook Meth N/S 

 0.000986 1.000 1.000 

 130-Uncooked; Dried; Cook Meth N/S 

 0.000986 1.000 1.000 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 211-Cooked; Fresh or N/S; Baked 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 212-Cooked; Fresh or N/S; Boiled 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 213-Cooked; Fresh or N/S; Fried 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 214-Cooked; Fresh or N/S; Fried/baked 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 215-Cooked; Fresh or N/S; Boiled/baked 

 0.000867 1.000 1.000 cookin 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 47 of 62 

 Full comment: cooking factor 

 220-Cooked; Frozen; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 221-Cooked; Frozen; Baked 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 222-Cooked; Frozen; Boiled 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 223-Cooked; Frozen; Fried 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 230-Cooked; Dried; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 231-Cooked; Dried; Baked 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 232-Cooked; Dried; Boiled 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 233-Cooked; Dried; Fried 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 240-Cooked; Canned; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 242-Cooked; Canned; Boiled 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 250-Cooked; Cured etc; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 251-Cooked; Cured etc; Baked 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 252-Cooked; Cured etc; Boiled 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

 253-Cooked; Cured etc; Fried 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

01032981 1C Potato, flour-babyfood 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.000986 1.000 1.000 

 130-Uncooked; Dried; Cook Meth N/S 

 0.000986 1.000 1.000 

 240-Cooked; Canned; Cook Meth N/S 

 0.000867 1.000 1.000 cookin 

 Full comment: cooking factor 

01032990 1C Potato, tuber, w/peel 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

01032991 1C Potato, tuber, w/peel-babyfood 1.000000 1.000 1.000 6 

01033000 1C Potato, tuber, w/o peel 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 5 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 211-Cooked; Fresh or N/S; Baked 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 212-Cooked; Fresh or N/S; Boiled 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 213-Cooked; Fresh or N/S; Fried 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 6 cookin 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 48 of 62 

 Full comment: cooking factor 

 223-Cooked; Frozen; Fried 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 232-Cooked; Dried; Boiled 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 233-Cooked; Dried; Fried 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 242-Cooked; Canned; Boiled 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 252-Cooked; Cured etc; Boiled 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

 253-Cooked; Cured etc; Fried 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

01033001 1C Potato, tuber, w/o peel-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 1.000000 1.000 1.000 6 cookin 

 Full comment: cooking factor 

86010000 O Water, direct, all sources 0.025200 1.000 1.000 

86020000 O Water, indirect, all sources 0.025200 1.000 1.000 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 49 of 62 

Attachment 11: Residue Input File – ETU Chronic and Cancer Analyses – Food Only 

Filename: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM 

Files\Metiram\ETUChronicmetiramPRIASept2006foodonly.R98 

Chemical: Metiram - ETU 

RfD(Chronic): .0002 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day 

RfD(Acute): .005 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0601 

Date created/last modified: 09-27-2006/14:45:48/8 Program ver. 2.03 

Comment: food only 

-------------------------------------------------------------------------------- 

 EPA Crop Def Res Adj.Factors Comment 

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ ------- 

11000070 11 Apple, fruit with peel 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.010000 1.000 0.150 

 150-Uncooked; Cured etc; Cook Meth N/S 

 0.010000 1.000 0.150 

 211-Cooked; Fresh or N/S; Baked 

 0.003700 1.000 0.150 

 213-Cooked; Fresh or N/S; Fried 

 0.003700 1.000 0.150 

11000080 11 Apple, peeled fruit 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.010000 1.000 0.150 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.003700 1.000 0.150 

 211-Cooked; Fresh or N/S; Baked 

 0.003700 1.000 0.150 

 213-Cooked; Fresh or N/S; Fried 

 0.003700 1.000 0.150 

 221-Cooked; Frozen; Baked 0.003700 1.000 0.150 

 232-Cooked; Dried; Boiled 0.003700 1.000 0.150 

 240-Cooked; Canned; Cook Meth N/S 

 0.003700 1.000 0.150 

11000081 11 Apple, peeled fruit-babyfood 0.003700 1.000 0.150 

11000090 11 Apple, dried 

 130-Uncooked; Dried; Cook Meth N/S 

 0.010000 1.000 0.150 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.003700 1.000 0.150 

 211-Cooked; Fresh or N/S; Baked 

 0.003700 1.000 0.150 

 230-Cooked; Dried; Cook Meth N/S 

 0.003700 1.000 0.150 

11000091 11 Apple, dried-babyfood 

 230-Cooked; Dried; Cook Meth N/S 

 0.003700 1.000 0.150 

11000100 11 Apple, juice 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.004900 1.000 0.150 

 120-Uncooked; Frozen; Cook Meth N/S 

 0.004900 1.000 0.150 

 130-Uncooked; Dried; Cook Meth N/S 

 0.004900 1.000 0.150 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.003800 1.000 0.150 

 211-Cooked; Fresh or N/S; Baked 

 0.003800 1.000 0.150 

 212-Cooked; Fresh or N/S; Boiled 

 0.003800 1.000 0.150 

 213-Cooked; Fresh or N/S; Fried 

 0.003800 1.000 0.150 

 214-Cooked; Fresh or N/S; Fried/baked 

 0.003800 1.000 0.150 

 230-Cooked; Dried; Cook Meth N/S 

 0.003800 1.000 0.150 

 240-Cooked; Canned; Cook Meth N/S 

 0.003800 1.000 0.150 

11000101 11 Apple, juice-babyfood 

 230-Cooked; Dried; Cook Meth N/S 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 50 of 62 

 0.003800 1.000 0.150 

 240-Cooked; Canned; Cook Meth N/S 

 0.003800 1.000 0.150 

11000110 11 Apple, sauce 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.010000 1.000 0.150 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.003700 1.000 0.150 

 211-Cooked; Fresh or N/S; Baked 

 0.003700 1.000 0.150 

 212-Cooked; Fresh or N/S; Boiled 

 0.003700 1.000 0.150 

 221-Cooked; Frozen; Baked 0.003700 1.000 0.150 

 240-Cooked; Canned; Cook Meth N/S 

 0.003700 1.000 0.150 

11000111 11 Apple, sauce-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 0.003700 1.000 0.150 

95000230 O Banana 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.031300 1.000 1.000 

 120-Uncooked; Frozen; Cook Meth N/S 

 0.031300 1.000 1.000 

 130-Uncooked; Dried; Cook Meth N/S 

 0.031300 1.000 1.000 

 211-Cooked; Fresh or N/S; Baked 

 0.023600 1.000 1.000 

 212-Cooked; Fresh or N/S; Boiled 

 0.023600 1.000 1.000 

 213-Cooked; Fresh or N/S; Fried 

 0.023600 1.000 1.000 

 223-Cooked; Frozen; Fried 0.023600 1.000 1.000 

 240-Cooked; Canned; Cook Meth N/S 

 0.023600 1.000 1.000 

95000231 O Banana-babyfood 

 211-Cooked; Fresh or N/S; Baked 

 0.031300 1.000 1.000 

 230-Cooked; Dried; Cook Meth N/S 

 0.031300 1.000 1.000 

 240-Cooked; Canned; Cook Meth N/S 

 0.031300 1.000 1.000 

95000240 O Banana, dried 

 130-Uncooked; Dried; Cook Meth N/S 

 0.028200 1.000 1.000 

 211-Cooked; Fresh or N/S; Baked 

 0.023600 1.000 1.000 

 230-Cooked; Dried; Cook Meth N/S 

 0.023600 1.000 1.000 

95000241 O Banana, dried-babyfood 0.023600 1.000 1.000 

95001750 O Grape 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.035200 1.000 0.440 

 120-Uncooked; Frozen; Cook Meth N/S 

 0.035200 1.000 0.440 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.026200 1.000 0.440 

 240-Cooked; Canned; Cook Meth N/S 

 0.026200 1.000 0.440 

95001760 O Grape, juice 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.032700 1.000 0.440 

 120-Uncooked; Frozen; Cook Meth N/S 

 0.032700 1.000 0.440 

 130-Uncooked; Dried; Cook Meth N/S 

 0.032700 1.000 0.440 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.018900 1.000 0.440 

 211-Cooked; Fresh or N/S; Baked 

 0.018900 1.000 0.440 

 221-Cooked; Frozen; Baked 0.018900 1.000 0.440 

 230-Cooked; Dried; Cook Meth N/S 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 51 of 62 

 0.018900 1.000 0.440 

 240-Cooked; Canned; Cook Meth N/S 

 0.018900 1.000 0.440 

95001761 O Grape, juice-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 0.018900 1.000 0.440 

95001770 O Grape, leaves 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.026200 1.000 0.440 

 211-Cooked; Fresh or N/S; Baked 

 0.026200 1.000 0.440 

95001780 O Grape, raisin 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.069000 1.000 0.440 

 130-Uncooked; Dried; Cook Meth N/S 

 0.069000 1.000 0.440 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.021100 1.000 0.440 

 211-Cooked; Fresh or N/S; Baked 

 0.021100 1.000 0.440 

 212-Cooked; Fresh or N/S; Boiled 

 0.021100 1.000 0.440 

 213-Cooked; Fresh or N/S; Fried 

 0.021100 1.000 0.440 

 221-Cooked; Frozen; Baked 0.021100 1.000 0.440 

 230-Cooked; Dried; Cook Meth N/S 

 0.021100 1.000 0.440 

 232-Cooked; Dried; Boiled 0.021100 1.000 0.440 

 240-Cooked; Canned; Cook Meth N/S 

 0.021100 1.000 0.440 

95001790 O Grape, wine and sherry 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.032700 1.000 0.200 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.018900 1.000 0.200 

 211-Cooked; Fresh or N/S; Baked 

 0.018900 1.000 0.200 

 212-Cooked; Fresh or N/S; Boiled 

 0.018900 1.000 0.200 

 213-Cooked; Fresh or N/S; Fried 

 0.018900 1.000 0.200 

 221-Cooked; Frozen; Baked 0.018900 1.000 0.200 

 230-Cooked; Dried; Cook Meth N/S 

 0.018900 1.000 0.200 

 240-Cooked; Canned; Cook Meth N/S 

 0.018900 1.000 0.200 

 242-Cooked; Canned; Boiled 0.018900 1.000 0.200 

 250-Cooked; Cured etc; Cook Meth N/S 

 0.018900 1.000 0.200 

01032960 1C Potato, chips 

 211-Cooked; Fresh or N/S; Baked 

 0.000300 1.000 0.100 

 213-Cooked; Fresh or N/S; Fried 

 0.000300 1.000 0.100 

01032970 1C Potato, dry (granules/ flakes) 0.008700 1.000 0.100 

01032971 1C Potato, dry (granules/ flakes)-b 0.008700 1.000 0.100 

01032980 1C Potato, flour 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.009900 1.000 0.100 

 120-Uncooked; Frozen; Cook Meth N/S 

 0.009900 1.000 0.100 

 130-Uncooked; Dried; Cook Meth N/S 

 0.009900 1.000 0.100 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.008700 1.000 0.100 

 211-Cooked; Fresh or N/S; Baked 

 0.008700 1.000 0.100 

 212-Cooked; Fresh or N/S; Boiled 

 0.008700 1.000 0.100 

 213-Cooked; Fresh or N/S; Fried 

 0.008700 1.000 0.100 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 52 of 62 

 214-Cooked; Fresh or N/S; Fried/baked 

 0.008700 1.000 0.100 

 215-Cooked; Fresh or N/S; Boiled/baked 

 0.008700 1.000 0.100 

 220-Cooked; Frozen; Cook Meth N/S 

 0.008700 1.000 0.100 

 221-Cooked; Frozen; Baked 0.008700 1.000 0.100 

 222-Cooked; Frozen; Boiled 0.008700 1.000 0.100 

 223-Cooked; Frozen; Fried 0.008700 1.000 0.100 

 230-Cooked; Dried; Cook Meth N/S 

 0.008700 1.000 0.100 

 231-Cooked; Dried; Baked 0.008700 1.000 0.100 

 232-Cooked; Dried; Boiled 0.008700 1.000 0.100 

 233-Cooked; Dried; Fried 0.008700 1.000 0.100 

 240-Cooked; Canned; Cook Meth N/S 

 0.008700 1.000 0.100 

 242-Cooked; Canned; Boiled 0.008700 1.000 0.100 

 250-Cooked; Cured etc; Cook Meth N/S 

 0.008700 1.000 0.100 

 251-Cooked; Cured etc; Baked 0.008700 1.000 0.100 

 252-Cooked; Cured etc; Boiled 0.008700 1.000 0.100 

 253-Cooked; Cured etc; Fried 0.008700 1.000 0.100 

01032981 1C Potato, flour-babyfood 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.009900 1.000 0.100 

 130-Uncooked; Dried; Cook Meth N/S 

 0.009900 1.000 0.100 

 240-Cooked; Canned; Cook Meth N/S 

 0.008700 1.000 0.100 

01032990 1C Potato, tuber, w/peel 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.003300 1.000 0.100 

 211-Cooked; Fresh or N/S; Baked 

 0.003300 1.000 0.100 

 212-Cooked; Fresh or N/S; Boiled 

 0.003300 1.000 0.100 

 213-Cooked; Fresh or N/S; Fried 

 0.003300 1.000 0.100 

01032991 1C Potato, tuber, w/peel-babyfood 0.003300 1.000 0.100 

01033000 1C Potato, tuber, w/o peel 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.002700 1.000 0.100 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.002700 1.000 0.100 

 211-Cooked; Fresh or N/S; Baked 

 0.002700 1.000 0.100 

 212-Cooked; Fresh or N/S; Boiled 

 0.002700 1.000 0.100 

 213-Cooked; Fresh or N/S; Fried 

 0.002700 1.000 0.100 

 221-Cooked; Frozen; Baked 0.002700 1.000 0.100 

 223-Cooked; Frozen; Fried 0.002700 1.000 0.100 

 232-Cooked; Dried; Boiled 0.002700 1.000 0.100 

 233-Cooked; Dried; Fried 0.002700 1.000 0.100 

 240-Cooked; Canned; Cook Meth N/S 

 0.002700 1.000 0.100 

 242-Cooked; Canned; Boiled 0.002700 1.000 0.100 

 252-Cooked; Cured etc; Boiled 0.002700 1.000 0.100 

 253-Cooked; Cured etc; Fried 0.002700 1.000 0.100 

01033001 1C Potato, tuber, w/o peel-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 0.002700 1.000 0.100 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 53 of 62 

Attachment 12: Residue Input File – ETU Chronic and Cancer Analyses – Food and 

Water 

Filename: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM 

Files\Metiram\ETUChronicmetiramPRIASept2006foodpluswater.R98 

Chemical: Metiram - ETU 

RfD(Chronic): .0002 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day 

RfD(Acute): .005 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0601 

Date created/last modified: 09-27-2006/14:46:41/8 Program ver. 2.03 

Comment: food plus water 

-------------------------------------------------------------------------------- 

 EPA Crop Def Res Adj.Factors Comment 

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ ------- 

11000070 11 Apple, fruit with peel 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.010000 1.000 0.150 

 150-Uncooked; Cured etc; Cook Meth N/S 

 0.010000 1.000 0.150 

 211-Cooked; Fresh or N/S; Baked 

 0.003700 1.000 0.150 

 213-Cooked; Fresh or N/S; Fried 

 0.003700 1.000 0.150 

11000080 11 Apple, peeled fruit 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.010000 1.000 0.150 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.003700 1.000 0.150 

 211-Cooked; Fresh or N/S; Baked 

 0.003700 1.000 0.150 

 213-Cooked; Fresh or N/S; Fried 

 0.003700 1.000 0.150 

 221-Cooked; Frozen; Baked 0.003700 1.000 0.150 

 232-Cooked; Dried; Boiled 0.003700 1.000 0.150 

 240-Cooked; Canned; Cook Meth N/S 

 0.003700 1.000 0.150 

11000081 11 Apple, peeled fruit-babyfood 0.003700 1.000 0.150 

11000090 11 Apple, dried 

 130-Uncooked; Dried; Cook Meth N/S 

 0.010000 1.000 0.150 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.003700 1.000 0.150 

 211-Cooked; Fresh or N/S; Baked 

 0.003700 1.000 0.150 

 230-Cooked; Dried; Cook Meth N/S 

 0.003700 1.000 0.150 

11000091 11 Apple, dried-babyfood 

 230-Cooked; Dried; Cook Meth N/S 

 0.003700 1.000 0.150 

11000100 11 Apple, juice 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.004900 1.000 0.150 

 120-Uncooked; Frozen; Cook Meth N/S 

 0.004900 1.000 0.150 

 130-Uncooked; Dried; Cook Meth N/S 

 0.004900 1.000 0.150 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.003800 1.000 0.150 

 211-Cooked; Fresh or N/S; Baked 

 0.003800 1.000 0.150 

 212-Cooked; Fresh or N/S; Boiled 

 0.003800 1.000 0.150 

 213-Cooked; Fresh or N/S; Fried 

 0.003800 1.000 0.150 

 214-Cooked; Fresh or N/S; Fried/baked 

 0.003800 1.000 0.150 

 230-Cooked; Dried; Cook Meth N/S 

 0.003800 1.000 0.150 

 240-Cooked; Canned; Cook Meth N/S 

 0.003800 1.000 0.150 

11000101 11 Apple, juice-babyfood 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 54 of 62 

 230-Cooked; Dried; Cook Meth N/S 

 0.003800 1.000 0.150 

 240-Cooked; Canned; Cook Meth N/S 

 0.003800 1.000 0.150 

11000110 11 Apple, sauce 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.010000 1.000 0.150 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.003700 1.000 0.150 

 211-Cooked; Fresh or N/S; Baked 

 0.003700 1.000 0.150 

 212-Cooked; Fresh or N/S; Boiled 

 0.003700 1.000 0.150 

 221-Cooked; Frozen; Baked 0.003700 1.000 0.150 

 240-Cooked; Canned; Cook Meth N/S 

 0.003700 1.000 0.150 

11000111 11 Apple, sauce-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 0.003700 1.000 0.150 

95000230 O Banana 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.031300 1.000 1.000 

 120-Uncooked; Frozen; Cook Meth N/S 

 0.031300 1.000 1.000 

 130-Uncooked; Dried; Cook Meth N/S 

 0.031300 1.000 1.000 

 211-Cooked; Fresh or N/S; Baked 

 0.023600 1.000 1.000 

 212-Cooked; Fresh or N/S; Boiled 

 0.023600 1.000 1.000 

 213-Cooked; Fresh or N/S; Fried 

 0.023600 1.000 1.000 

 223-Cooked; Frozen; Fried 0.023600 1.000 1.000 

 240-Cooked; Canned; Cook Meth N/S 

 0.023600 1.000 1.000 

95000231 O Banana-babyfood 

 211-Cooked; Fresh or N/S; Baked 

 0.031300 1.000 1.000 

 230-Cooked; Dried; Cook Meth N/S 

 0.031300 1.000 1.000 

 240-Cooked; Canned; Cook Meth N/S 

 0.031300 1.000 1.000 

95000240 O Banana, dried 

 130-Uncooked; Dried; Cook Meth N/S 

 0.028200 1.000 1.000 

 211-Cooked; Fresh or N/S; Baked 

 0.023600 1.000 1.000 

 230-Cooked; Dried; Cook Meth N/S 

 0.023600 1.000 1.000 

95000241 O Banana, dried-babyfood 0.023600 1.000 1.000 

95001750 O Grape 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.035200 1.000 0.440 

 120-Uncooked; Frozen; Cook Meth N/S 

 0.035200 1.000 0.440 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.026200 1.000 0.440 

 240-Cooked; Canned; Cook Meth N/S 

 0.026200 1.000 0.440 

95001760 O Grape, juice 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.032700 1.000 0.440 

 120-Uncooked; Frozen; Cook Meth N/S 

 0.032700 1.000 0.440 

 130-Uncooked; Dried; Cook Meth N/S 

 0.032700 1.000 0.440 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.018900 1.000 0.440 

 211-Cooked; Fresh or N/S; Baked 

 0.018900 1.000 0.440 

 221-Cooked; Frozen; Baked 0.018900 1.000 0.440 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 55 of 62 

 230-Cooked; Dried; Cook Meth N/S 

 0.018900 1.000 0.440 

 240-Cooked; Canned; Cook Meth N/S 

 0.018900 1.000 0.440 

95001761 O Grape, juice-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 0.018900 1.000 0.440 

95001770 O Grape, leaves 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.026200 1.000 0.440 

 211-Cooked; Fresh or N/S; Baked 

 0.026200 1.000 0.440 

95001780 O Grape, raisin 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.069000 1.000 0.440 

 130-Uncooked; Dried; Cook Meth N/S 

 0.069000 1.000 0.440 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.021100 1.000 0.440 

 211-Cooked; Fresh or N/S; Baked 

 0.021100 1.000 0.440 

 212-Cooked; Fresh or N/S; Boiled 

 0.021100 1.000 0.440 

 213-Cooked; Fresh or N/S; Fried 

 0.021100 1.000 0.440 

 221-Cooked; Frozen; Baked 0.021100 1.000 0.440 

 230-Cooked; Dried; Cook Meth N/S 

 0.021100 1.000 0.440 

 232-Cooked; Dried; Boiled 0.021100 1.000 0.440 

 240-Cooked; Canned; Cook Meth N/S 

 0.021100 1.000 0.440 

95001790 O Grape, wine and sherry 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.032700 1.000 0.200 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.018900 1.000 0.200 

 211-Cooked; Fresh or N/S; Baked 

 0.018900 1.000 0.200 

 212-Cooked; Fresh or N/S; Boiled 

 0.018900 1.000 0.200 

 213-Cooked; Fresh or N/S; Fried 

 0.018900 1.000 0.200 

 221-Cooked; Frozen; Baked 0.018900 1.000 0.200 

 230-Cooked; Dried; Cook Meth N/S 

 0.018900 1.000 0.200 

 240-Cooked; Canned; Cook Meth N/S 

 0.018900 1.000 0.200 

 242-Cooked; Canned; Boiled 0.018900 1.000 0.200 

 250-Cooked; Cured etc; Cook Meth N/S 

 0.018900 1.000 0.200 

01032960 1C Potato, chips 

 211-Cooked; Fresh or N/S; Baked 

 0.000300 1.000 0.100 

 213-Cooked; Fresh or N/S; Fried 

 0.000300 1.000 0.100 

01032970 1C Potato, dry (granules/ flakes) 0.008700 1.000 0.100 

01032971 1C Potato, dry (granules/ flakes)-b 0.008700 1.000 0.100 

01032980 1C Potato, flour 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.009900 1.000 0.100 

 120-Uncooked; Frozen; Cook Meth N/S 

 0.009900 1.000 0.100 

 130-Uncooked; Dried; Cook Meth N/S 

 0.009900 1.000 0.100 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.008700 1.000 0.100 

 211-Cooked; Fresh or N/S; Baked 

 0.008700 1.000 0.100 

 212-Cooked; Fresh or N/S; Boiled 

 0.008700 1.000 0.100 

 213-Cooked; Fresh or N/S; Fried 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 56 of 62 

 0.008700 1.000 0.100 

 214-Cooked; Fresh or N/S; Fried/baked 

 0.008700 1.000 0.100 

 215-Cooked; Fresh or N/S; Boiled/baked 

 0.008700 1.000 0.100 

 220-Cooked; Frozen; Cook Meth N/S 

 0.008700 1.000 0.100 

 221-Cooked; Frozen; Baked 0.008700 1.000 0.100 

 222-Cooked; Frozen; Boiled 0.008700 1.000 0.100 

 223-Cooked; Frozen; Fried 0.008700 1.000 0.100 

 230-Cooked; Dried; Cook Meth N/S 

 0.008700 1.000 0.100 

 231-Cooked; Dried; Baked 0.008700 1.000 0.100 

 232-Cooked; Dried; Boiled 0.008700 1.000 0.100 

 233-Cooked; Dried; Fried 0.008700 1.000 0.100 

 240-Cooked; Canned; Cook Meth N/S 

 0.008700 1.000 0.100 

 242-Cooked; Canned; Boiled 0.008700 1.000 0.100 

 250-Cooked; Cured etc; Cook Meth N/S 

 0.008700 1.000 0.100 

 251-Cooked; Cured etc; Baked 0.008700 1.000 0.100 

 252-Cooked; Cured etc; Boiled 0.008700 1.000 0.100 

 253-Cooked; Cured etc; Fried 0.008700 1.000 0.100 

01032981 1C Potato, flour-babyfood 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.009900 1.000 0.100 

 130-Uncooked; Dried; Cook Meth N/S 

 0.009900 1.000 0.100 

 240-Cooked; Canned; Cook Meth N/S 

 0.008700 1.000 0.100 

01032990 1C Potato, tuber, w/peel 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.003300 1.000 0.100 

 211-Cooked; Fresh or N/S; Baked 

 0.003300 1.000 0.100 

 212-Cooked; Fresh or N/S; Boiled 

 0.003300 1.000 0.100 

 213-Cooked; Fresh or N/S; Fried 

 0.003300 1.000 0.100 

01032991 1C Potato, tuber, w/peel-babyfood 0.003300 1.000 0.100 

01033000 1C Potato, tuber, w/o peel 

 110-Uncooked; Fresh or N/S; Cook Meth N/S 

 0.002700 1.000 0.100 

 210-Cooked; Fresh or N/S; Cook Meth N/S 

 0.002700 1.000 0.100 

 211-Cooked; Fresh or N/S; Baked 

 0.002700 1.000 0.100 

 212-Cooked; Fresh or N/S; Boiled 

 0.002700 1.000 0.100 

 213-Cooked; Fresh or N/S; Fried 

 0.002700 1.000 0.100 

 221-Cooked; Frozen; Baked 0.002700 1.000 0.100 

 223-Cooked; Frozen; Fried 0.002700 1.000 0.100 

 232-Cooked; Dried; Boiled 0.002700 1.000 0.100 

 233-Cooked; Dried; Fried 0.002700 1.000 0.100 

 240-Cooked; Canned; Cook Meth N/S 

 0.002700 1.000 0.100 

 242-Cooked; Canned; Boiled 0.002700 1.000 0.100 

 252-Cooked; Cured etc; Boiled 0.002700 1.000 0.100 

 253-Cooked; Cured etc; Fried 0.002700 1.000 0.100 

01033001 1C Potato, tuber, w/o peel-babyfood 

 240-Cooked; Canned; Cook Meth N/S 

 0.002700 1.000 0.100 

86010000 O Water, direct, all sources 0.000210 1.000 1.000 

86020000 O Water, indirect, all sources 0.000210 1.000 1.000 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 57 of 62 

Attachment 13: Results File – ETU Acute Analysis – Food Only 

U.S. Environmental Protection Agency Ver. 2.02 

DEEM-FCID ACUTE Analysis for ETU (1994-98 data) 

Residue file: ETUAcutemetiramPRIAsept2006foodonly.R98 

Adjustment factor #2 NOT used. 

Analysis Date: 09-27-2006/14:48:14 Residue file dated: 09-27-2006/14:29:18/8 

Daily totals for food and foodform consumption used. 

MC iterations = 1000 MC list in residue file MC seed = 10 

Run Comment: "Females 13+ only" 

=============================================================================== 

Summary calculations (per capita): 

 95th Percentile 99th Percentile 99.9th Percentile 

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- -------- 

Females 13-49 yrs: 

 0.000066 1.33 0.000138 2.77 0.000299 5.98 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 58 of 62 

Attachment 14: Results File – ETU Acute Analysis – Food and Water 

U.S. Environmental Protection Agency Ver. 2.02 

DEEM-FCID ACUTE Analysis for ETU (1994-98 data) 

Residue file: ETUAcutemetiramPRIAsept2006foodand water.R98 

Adjustment factor #2 NOT used. 

Analysis Date: 09-27-2006/15:01:14 Residue file dated: 09-27-2006/14:32:56/8 

Daily totals for food and foodform consumption used. 

MC iterations = 1000 MC list in residue file MC seed = 10 

Run Comment: "Females 13+ only food plus water" 

=============================================================================== 

Summary calculations (per capita): 

 95th Percentile 99th Percentile 99.9th Percentile 

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- -------- 

Females 13-49 yrs: 

 0.001242 24.83 0.001989 39.79 0.003511 70.21 
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 59 of 62 

Attachment 15: Results File – ETU Chronic Analysis – Food Only 

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for METIRAM - ETU (1994-98 data) 

Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM 

Files\Metiram\ETUChronicmetiramPRIASept2006foodonly.R98 

 Adjustment factor #2 used. 

Analysis Date 09-27-2006/15:02:22 Residue file dated: 09-27-2006/14:45:48/8 

Reference dose (RfD, Chronic) = .0002 mg/kg bw/day 

COMMENT 1: food only 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- --------------- 

U.S. Population (total) 0.000018 9.0% 

U.S. Population (spring season) 0.000018 8.8% 

U.S. Population (summer season) 0.000018 8.9% 

U.S. Population (autumn season) 0.000018 8.9% 

U.S. Population (winter season) 0.000019 9.5% 

Northeast region 0.000019 9.7% 

Midwest region 0.000018 9.0% 

Southern region 0.000015 7.7% 

Western region 0.000021 10.5% 

Hispanics 0.000021 10.6% 

Non-hispanic whites 0.000018 9.0% 

Non-hispanic blacks 0.000015 7.3% 

Non-hisp/non-white/non-black 0.000020 9.8% 

All infants (< 1 year) 0.000051 25.4% 

Nursing infants 0.000035 17.5% 

Non-nursing infants 0.000057 28.4% 

Children 1-6 yrs 0.000067 33.4% 

Children 7-12 yrs 0.000021 10.3% 

Females 13-19 (not preg or nursing) 0.000008 3.9% 

Females 20+ (not preg or nursing) 0.000013 6.4% 

Females 13-50 yrs 0.000013 6.3% 

Females 13+ (preg/not nursing) 0.000013 6.4% 

Females 13+ (nursing) 0.000016 8.2% 

Males 13-19 yrs 0.000007 3.7% 

Males 20+ yrs 0.000011 5.5% 

Seniors 55+ 0.000016 7.8% 

Children 1-2 yrs 0.000100 50.2% 

Children 3-5 yrs 0.000056 28.2% 

Children 6-12 yrs 0.000022 11.1% 

Youth 13-19 yrs 0.000008 3.8% 

Adults 20-49 yrs 0.000010 5.1% 

Adults 50+ yrs 0.000015 7.6% 

Females 13-49 yrs 0.000011 5.3% 

-----------------------------------------------------------------------------
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 60 of 62 

Attachment 16: Results File – ETU Chronic Analysis – Food and Water 

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for METIRAM - ETU (1994-98 data) 

Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM 

Files\Metiram\ETUChronicmetiramPRIASept2006foodpluswater.R98 

 Adjustment factor #2 used. 

Analysis Date 09-27-2006/15:05:18 Residue file dated: 09-27-2006/14:46:41/8 

Reference dose (RfD, Chronic) = .0002 mg/kg bw/day 

COMMENT 1: food plus water 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- --------------- 

U.S. Population (total) 0.000022 11.2% 

U.S. Population (spring season) 0.000022 11.0% 

U.S. Population (summer season) 0.000023 11.3% 

U.S. Population (autumn season) 0.000022 11.1% 

U.S. Population (winter season) 0.000023 11.6% 

Northeast region 0.000023 11.7% 

Midwest region 0.000022 11.2% 

Southern region 0.000020 9.8% 

Western region 0.000026 13.1% 

Hispanics 0.000026 13.1% 

Non-hispanic whites 0.000022 11.2% 

Non-hispanic blacks 0.000019 9.4% 

Non-hisp/non-white/non-black 0.000025 12.5% 

All infants (< 1 year) 0.000065 32.6% 

Nursing infants 0.000040 20.2% 

Non-nursing infants 0.000075 37.4% 

Children 1-6 yrs 0.000073 36.5% 

Children 7-12 yrs 0.000025 12.3% 

Females 13-19 (not preg or nursing) 0.000011 5.4% 

Females 20+ (not preg or nursing) 0.000017 8.6% 

Females 13-50 yrs 0.000017 8.4% 

Females 13+ (preg/not nursing) 0.000017 8.5% 

Females 13+ (nursing) 0.000022 11.2% 

Males 13-19 yrs 0.000011 5.3% 

Males 20+ yrs 0.000015 7.5% 

Seniors 55+ 0.000020 10.0% 

Children 1-2 yrs 0.000107 53.5% 

Children 3-5 yrs 0.000063 31.3% 

Children 6-12 yrs 0.000027 13.3% 

Youth 13-19 yrs 0.000011 5.4% 

Adults 20-49 yrs 0.000014 7.1% 

Adults 50+ yrs 0.000020 9.8% 

Females 13-49 yrs 0.000015 7.4% 

------------------------------------------------------------------------------
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 61 of 62 

Attachment 17: Results File – ETU Cancer Analysis – Food Only 

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for METIRAM - ETU (1994-98 data) 

Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM 

Files\Metiram\ETUChronicmetiramPRIASept2006foodonly.R98 

 Adjustment factor #2 used. 

Analysis Date 09-27-2006/15:02:44 Residue file dated: 09-27-2006/14:45:48/8 

Q* = 0.0601 

COMMENT 1: food only 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Lifetime risk 

 Subgroup body wt/day (Q*= .0601) 

-------------------------------------- ------------- ------------- 

U.S. Population (total) 0.000018 1.08E-06 

U.S. Population (spring season) 0.000018 1.05E-06 

U.S. Population (summer season) 0.000018 1.07E-06 

U.S. Population (autumn season) 0.000018 1.07E-06 

U.S. Population (winter season) 0.000019 1.14E-06 

Northeast region 0.000019 1.16E-06 

Midwest region 0.000018 1.08E-06 

Southern region 0.000015 9.30E-07 

Western region 0.000021 1.27E-06 

Hispanics 0.000021 1.27E-06 

Non-hispanic whites 0.000018 1.09E-06 

Non-hispanic blacks 0.000015 8.81E-07 

Non-hisp/non-white/non-black 0.000020 1.18E-06 

All infants (< 1 year) 0.000051 3.05E-06 

Nursing infants 0.000035 2.11E-06 

Non-nursing infants 0.000057 3.41E-06 

Children 1-6 yrs 0.000067 4.02E-06 

Children 7-12 yrs 0.000021 1.24E-06 

Females 13-19 (not preg or nursing) 0.000008 4.67E-07 

Females 20+ (not preg or nursing) 0.000013 7.74E-07 

Females 13-50 yrs 0.000013 7.57E-07 

Females 13+ (preg/not nursing) 0.000013 7.63E-07 

Females 13+ (nursing) 0.000016 9.82E-07 

Males 13-19 yrs 0.000007 4.43E-07 

Males 20+ yrs 0.000011 6.60E-07 

Seniors 55+ 0.000016 9.43E-07 

Children 1-2 yrs 0.000100 6.03E-06 

Children 3-5 yrs 0.000056 3.39E-06 

Children 6-12 yrs 0.000022 1.34E-06 

Youth 13-19 yrs 0.000008 4.54E-07 

Adults 20-49 yrs 0.000010 6.09E-07 

Adults 50+ yrs 0.000015 9.17E-07 

Females 13-49 yrs 0.000011 6.37E-07 

------------------------------------------------------------------------------
Metiram Dietary Exposure Assessment DP Number: 326753 

PC Code: 014601 

Page 62 of 62 

Attachment 18: Results File – ETU Cancer Analysis – Food and Water

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for METIRAM - ETU (1994-98 data) 

Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM 

Files\Metiram\ETUChronicmetiramPRIASept2006foodpluswater.R98 

 Adjustment factor #2 used. 

Analysis Date 09-27-2006/15:14:46 Residue file dated: 09-27-2006/14:46:41/8 

Q* = 0.0601 

COMMENT 1: food plus water 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Lifetime risk 

 Subgroup body wt/day (Q*= .0601) 

-------------------------------------- ------------- ------------- 

U.S. Population (total) 0.000022 1.35E-06 

U.S. Population (spring season) 0.000022 1.32E-06 

U.S. Population (summer season) 0.000023 1.36E-06 

U.S. Population (autumn season) 0.000022 1.33E-06 

U.S. Population (winter season) 0.000023 1.40E-06 

Northeast region 0.000023 1.41E-06 

Midwest region 0.000022 1.35E-06 

Southern region 0.000020 1.18E-06 

Western region 0.000026 1.57E-06 

Hispanics 0.000026 1.57E-06 

Non-hispanic whites 0.000022 1.35E-06 

Non-hispanic blacks 0.000019 1.13E-06 

Non-hisp/non-white/non-black 0.000025 1.51E-06 

All infants (< 1 year) 0.000065 3.92E-06 

Nursing infants 0.000040 2.43E-06 

Non-nursing infants 0.000075 4.49E-06 

Children 1-6 yrs 0.000073 4.39E-06 

Children 7-12 yrs 0.000025 1.48E-06 

Females 13-19 (not preg or nursing) 0.000011 6.54E-07 

Females 20+ (not preg or nursing) 0.000017 1.04E-06 

Females 13-50 yrs 0.000017 1.01E-06 

Females 13+ (preg/not nursing) 0.000017 1.02E-06 

Females 13+ (nursing) 0.000022 1.35E-06 

Males 13-19 yrs 0.000011 6.39E-07 

Males 20+ yrs 0.000015 8.98E-07 

Seniors 55+ 0.000020 1.20E-06 

Children 1-2 yrs 0.000107 6.43E-06 

Children 3-5 yrs 0.000063 3.76E-06 

Children 6-12 yrs 0.000027 1.59E-06 

Youth 13-19 yrs 0.000011 6.46E-07 

Adults 20-49 yrs 0.000014 8.58E-07 

Adults 50+ yrs 0.000020 1.18E-06 

Females 13-49 yrs 0.000015 8.84E-07 

------------------------------------------------------------------------------