### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 1 of 62 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES 

## MEMORANDUM

DATE: 17-April-2007

SUBJECT: PP# 9E6006 Metiram Acute, Chronic, and Cancer Dietary Exposure Assessments for New Tolerances on Imported Grapes and Bananas.

PC Code: 014601 DP Number: 326753

REVIEWER: Christine L. Olinger, Chemist Reregistration Branch I Health Effects Division (7509P)

THROUGH: Michael S. Metzger, Chief Reregistration Branch 1 Health Effects Division (7509P)

Sheila Piper, Chemist Felecia Fort, Chemist Dietary Exposure Science Advisory Council Health Effects Division (7509P)

TO: Cynthia Giles-Parker, Chief Fungicide Branch Registration Division (7505P)

Executive Summary

BASF Corporation has submitted a petition for tolerances on imported bananas and grapes for the fungicide metiram. Metiram is in the class of et hylene bisdithiocarbamate fungicides (EBDCs), which all produce the common metabolite and environmental degradate, ethylene thiourea (ETU). This memorandum reports the results of a dietary exposure analysis for metiram and ETU, resulting from applications of metiram. A separate memorandum will report the results of an analysis of the aggregate exposure of ETU from all of the EBDCs

. The most recent dietary exposure analysis was conducted in support of the reregistration of the EBDCs (F. Fort, 6/1/2006, DP Number 291664), which included the proposed tolerance on wine grapes using preliminary residue data.

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 2 of 62 Acute, chronic, and cancer dietary exposure assessmen ts were performed for the general U.S. population and various population subgroups to determine the exposure and risk estimates which result from the use of metiram and ETU. Tolerances are currently established in 40 CFR 180.217 for apples (0.1 ppm) and potatoes (0.05 ppm). The petitioner has proposed import tolerances for grapes and bananas; HED has recommended levels of 5 and 3 ppm, respectively, based on the residue data submitted. No residues are expected in livestock; therefore, no tolerances are needed to cover secondary residues in livestock commodities (Category 3 of 40 CFR §180.6(a)). Field trial data and percent crop treated information were used for apple and wine grapes; EBDC Market Basket Survey data were used for potatoes.

Acute Dietary Exposure Results For Metiram, the acute risk estimates are below the Agency’s level of concern at the 99.9 th 

## exposure percentile for females 13-49 years old, the population subgroup of concern (19% of the a PAD). Acute risk estimates for females 13-49 years old are also below HED’s level of concern for ETU with 70% of the aPAD occupied for food and water.

Chronic Dietary Exposure Results The chronic risk estimates are below the Agency’s level of concern for metiram and ETU for the general U.S. population and all population subgroups. The mo st highly exposed population subgroup is children ages 1-2 with an estimate for metiram for food al one of 70% of the cPAD. For ETU from metiram sources, the estimate for children ages 1-2 is at 50% of the cPAD for food alone, and 54% for food and water combined.

Cancer Dietary Exposure Results The cancer risk estimate associated with exposure to ETU from metiram is 1.4 x 10 -6 

## for the general U.S. population, and is below the Agency’s level of concern.

The acute, chronic, and cancer assessments can be considered somewhat refined. Residue estimates were refined using consumer processing f actors (washing, cooking), commercial processing (winemaking, juice), percent crop treated factors (domestic uses only), and monitoring data for one commodity (potatoes). Percent crop treated information is not available for the uses on imported crops (bananas and grapes), residue estimates were refined slightly using percent imported. Crop field trial data were used for all crops except potatoes, which are likely to provide higher estimates than actual

exposures.

I. Introduction

Dietary risk assessment incorporates both exposure a nd toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 3 of 62 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one in one million. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-AUG-1999).

The most recent dietary exposure analysis was conduc ted in support of the reregistration of the EBDCs (F. Fort, 6/1/2006, DP Number 291664), which included the proposed tolerance on wine grapes using preliminary residue data.

II. Residue Information

In 1977, the Agency initiated a Special Review and Continued Registration of Pesticide Products containing ethylene bisdithiocarbamates (EBDCs); metir am belongs to the EBDC group of fungicides. The need for Special Review of the EBDCs was based on evidence suggesting that the EBDCs and ethylene thiourea (ETU), a metabolite and degradation product of these pesticides posed potential risks to human health and the environment. In 1982, the Agency concluded this Special Review by issuing a Final Determination (PD 4) which required risk reduction measures to prevent unreasonable adverse effects pending development and submission of additional data needed for improved risk assessment.

In 1987, EPA issued a second Notice of Initiation of Speci al Review of the EBDC pesticides because of health concerns caused by ETU. The Special Review’s Preliminary Determination (PD 2/3) was published on 12/20/89 (54 FR 52158) and the Final Dete rmination (PD 4) on 3/2/92 (57 FR 7484). It was determined that the dietary risks of EBDCs exceed the benefits for the following food/feed uses for which one or more of the EBDC pesticides are registered: apricots, carrots, celery, collards, mustard greens, nectarines, peaches, rhubarb, spinach, succulent beans, and turnips. Accordingly, EPA has canceled all metiram and other EBDC products registered on the above-listed food/feed crops. Currently, the only food/feed uses of metiram eligible for continued registration are apples and potatoes.

Metiram tolerances are established under 40 CFR §180.217 and are currently expressed in terms of residues of a fungicide that is a mixture of 5.2 parts by weight of ammoniates of [ethylenebis(dithiocarbamato)]zinc with 1 part by we ight ethylenebis [dithiocarbamic acid] bimolecular and trimolecular cyclic anhydrosulfides and disulfides, calculated as zinc ethylenebisdithiocarbamate (zineb). The HED Metabolism Assessment Review Committee (MARC) has recommended a change in the tolerance expression for metiram and the other EBDCs with registered uses, mancozeb and maneb. The EBDC tolerance expressions will be revised to include residues of the parent EBDC only, calculated as CS 2 

## , rather than as zineb. Dietary exposure and risk assessments will continue to include residues of ethylene thiourea (ETU), a metabolite common to all EBDCs. This change will serve to update the CFR to include only those EBDCs with registered uses, and will also allow the Agency to harmonize its EBDC tolerance definitions with CODEX. The Metiram Update concluded that analytical methods converting EBDCs and some metabolites to carbon disulfide will be considered adequate for enforcement, along with a specific method for ETU.

Residue Data used for Acute, Chronic, and/or Cancer Assessments:

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## Page 4 of 62 A summary of the residue inputs can be found as an attachment to this document. BASF Corporation submitted banana and grape residue data, as well as grape processing data. Detailed information on the derivation of the existing uses of metiram may be found in the original anticipated residue memorandum (F. Fort, 10/21/2003, DP Number 290038). Attachment 1 to this document includes a detailed description of the estimation of the anticipated residues for the proposed new tolerances.

Acute Anticipated Residues

For the probabilistic acute dietary exposure analysis, the entire distribution of residue data from field trials or monitoring data were used to generate residue distribution files (RDFs) for commodities that are considered to be not blended or partially blended (see Attachments). For commodities considered to be blended in this analysis, the average residues incorporating the likely maximum estimated % CT was used as a point estimate. Processing and cooking f actors from studies with metiram and other EBDCs were used as well.

Chronic Anticipated Residues

Chronic anticipated residues were also calculated from field trial or monitoring data for metiram and ETU. Averages of the field trials were used for th e new tolerances, while field trial and market basket survey data were used for established uses. Pro cessing and cooking factors from studies with metiram and other EBDCs were used as well.

Usage Data

BEAD provided information (J. Carter, 3/22/05, Attach ment 3) on the percent crop treated (%CT) for the existing uses. Percent imported was used as a surrogate for percent crop treated as all of the proposed new tolerances are for imported commodities, and percent crop treated information from the foreign uses are not available. BEAD estimated 100% imported for bananas, 44% for fresh grapes (also used for dried grapes and grape juice), and 20% fo r wine (J. Alsadek, 8/11/2006, Attachment 4). For the chronic analysis, the weighted average %CT was incorporated; for the acute analysis, the estimated maximum %CT was used when appropriate.

In acute analyses (except blended commodities) the adjustment for %CT is incorporated in the residue distribution files (RDFs) via addition of zero residue values corresponding to the % of crop not treated. For blended/not further processed commodities where monitoring data are available, the entire distribution of monitoring data with no further adju stment for %CT were used. For blended/processed commodities where monitoring data are available and for all blended commodities where field trial data were used, %CT is incorporated into a point estimate. For the chronic analyses, the %CT is listed as Adjustment Factor 2 in the DEEM analysis.

Processing Factors

The metiram processing factors were obtained from processing studies submitted by the registrant and

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## Page 5 of 62 were compiled in a memo entitled “Reregistration of Mancozeb, Maneb, and Metiram : Processing and Cooking Factors to be Used in the Dietary Risk A ssessment”, C. Olinger, October 2003. These factors include cooking, peeling, washing and processing factor s. Wine processing data from metiram specific studies submitted in support of the petition were used as well.

III. Drinking Water Data The Environmental Fate and Effects Division (EFED) has provided information on the ability of metiram and the degradate ETU to reach drinki ng water sources. (Ruhman and Parker, 8/11/06, DP Numbers 323143 and 323141). Metiram, like the other EBDC fungicides, are expected to degrade relatively quickly in the environment, so is not expected to reach drinking water sources. EFED has estimated drinking water concentrations of ETU in surface water and groundwater using monitoring data, and modeled estimates where monitoring data are not available. According to the 8/11/06 memo,

• the chronic EDWC for surface water is 0.1 ppb of ETU based on a monitoring study conducted by the EBDC Task Force;

• A range of acute EDWCs is established with a lower limit of 0.1 ppb of ETU (based on monitoring) and an upper limit of 25.2 ppb of ETU (based on e nvironmental fate and transport simulation modeling using the linked EPA PRZM and EXAMS models); and

• The ground water EDWC is 0.21 ppb of ETU (based on a targeted monitoring study).

Water residues were incorporated in the DEEM-FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.” The upper limit from PRZM/EXAMS was used for the acute assessment and the groundwater EDWC was used for the chronic and cancer assessments, as these estimates provided an upper bound estimate of water exposure.

IV. DEEM-FCID TM Program and Consumption Information

Metiram acute, chronic and cancer dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID TM , Version 2.03), which incorporates consumption data from USDA’s Continuing Surveys of Food Intakes by Individuals (CSFII), 1994-1996 and 1998. The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. Consumption data are averaged for the entire U.S. population and within population subgroups for chronic exposure assessment, but are retained as individual consumption events for acute exposure assessment.

For chronic exposure and risk assessment, an estimate of the residue level in each food or food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form. The resulting residue consumption estimate for each food/food form is summed with the residue consumption estimates for all other food/food forms on the commodity residue list

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## Page 6 of 62 to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an individualby-individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., those who reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis. However, for deterministic assessments, significant differences in user vs. per capita exposure and risk are identified and noted in the risk assessment.

V. Toxicological Information

The HED Hazard Identification Assessment Review Committee (HIARC) on February 20, 2003 reevaluated the toxicology data base of metiram a nd ETU and selected toxicology endpoints for chronic and acute dietary as well as cancer for ETU. The sel ected toxicological endpoints and the doses for risk assessment and additional relevant details are summarized in Table 1. Based on the weight of evidence presented, the HIARC determined that a 10X database uncertainty factor (UF DB 

## ) is needed for metiram to account for the lack of 1) Acute Neurotoxicity Study in the Rat; 2) Developmental Toxicity Study in the Rabbit; 3) Two-Generation Reproduction Study in the Rat; 4) Developmental Neurotoxicity Study in the Rat; and 5) Comparative Thyroid Assay Between Adult and Young Animals studies since the available data provide no basis to support reduction or removal of the default 10X factor. For ETU, the HIARC concluded that a Database Uncertainty Factor of 10x is required until a developmental neurotoxicity study is received and evaluated.

The HED Cancer Assessment Review Committee classified ETU as a group B2 probable human carcinogen (Bill Sette, Ph.D. memo, 4/16/90 and Albi n Kocialski, Ph.D. memo, 9/26/91). The Q 1 

## * for ETU, using a 3/4 scaling factor, was determined to be 6.01 x 10 -2 

## mg/kg/day -1 

## based upon female mouse liver tumors in the NTP study (Bernice Fisher and Hugh Pettigrew memo, 2/24/95). The Q 1 

## * for ETU is also used for the EBDC compounds, mancozeb, metiram, and maneb which are metabolized to ETU (HED Document No. 013554, 7/7/99).

Table 1. Summary of Toxicology Endpoint Selection for Metiram and ETU

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## Page 7 of 62 Exposure Scenario Point of Departure/ Uncertainty and

FQPA Safety Factors Level of Concern for Risk Assessment Study and Toxicological Effects

METIRAM Acute Dietary females 13-50 years of age NOAEL = 10 mg/kg/day UF A 

### = 10x UF H 

### =10x FQPA SF= 10x [Database Uncertainty Factor ] Acute RfD = 0.01 mg/kg/day

aPAD =

= 0.01 mg/kg/day Rabbit developmental toxicity study LOAEL = 40 mg ai/kg/day based on abortions

Acute Dietary general population including infants and children NOAEL = N/A No appropriate endpoint from oral toxicity studies was identified.

Chronic Dietary (All populations) NOAEL = 0.4 mg/kg/day UF A 

### = 10x UF H 

### =10x FQPA SF= 10x [Database Uncertainty Factor ] Chronic RfD = 0.0004 mg/kg/day

cPAD =

= 0.0004 mg/kg/day Subchronic oral toxicity study in rats LOAEL = 5.8 mg/kg/day, based on decreased forelimb grip strength

ETU

Acute Dietary Females 13-50 years

age NOAEL = 5 mg/kg/day UF A 

### = 10x UF H 

### =10x FQPA SF= 10x [Database Uncertainty Factor ] Acute RfD = 0.005 mg/kg/day

aPAD = 0.005 mg/kg/day Developmental rat study (Khera) LOAEL = 10 mg/kg/day based on developmental defects of brain.

Acute Dietary General Population including infants/children NOAEL = N/A No appropriate endpoint from oral toxicity studies was identified.

Chronic Dietary All populations NOAEL = 0.18 mg/kg/day UF A 

### = 10x UF H 

### =10x FQPA SF= 10x [Database Uncertainty Factor ] Chronic RfD = 0.0002 mg/kg/day

cPAD = 0.0002 mg/kg/day Dog chronic toxicity study. LOAEL = 1.99 mg/kg/day based on thyroid toxicity.

Carcinogenicity Q 1 

### * = 0.0601 (mg/kg/day) -1 

### B2 carcinogen with low-dose extrapolation for human risk assessment based on liver tumors in female mice. Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to mark the beginning of extrapolation to determine risk associ ated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest obser ved adverse effect level. UF = uncertainty factor. UF A 

### = extrapolation from animal to human (intraspecies). UF H 

### = potential variation in sensitivity among members of the human population (interspecies). UF DB 

### = to account for the absence of key date (i.e ., lack of a critical study). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. N/A = not applicable.

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 8 of 62 VI. Results/Discussion

As stated above, for acute and chronic assessments , HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM-FCID TM analyses estimate the dietary exposure of the U.S. population and 26 population subgroups. The results reported in Table 2 are for females 13-49 years old, the population subgroup of toxicological concern for acute assessments and in Table 3 (chronic assessments) are for the general U.S. Population, all infants (<1 year ol d), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years. Cancer risk is determined for the general U.S. population only.

Results of Acute Dietary Exposure Analysis Acute assessments were conducted for metiram and ETU and are presented in Table 2. Results are reported at the 99.9th percentile of exposure because the assessment incorporated anticipated residues and estimates of %CT.

Table 2. Results of Acute Dietary Exposure Analysis for Metiram and ETU

Population Subgroup aPAD (mg/kg/day) 95 th 

### Percentile 99 th 

### Percentile 99.9 th 

### Percentile

Exposure (mg/kg/day) % aPAD Exposure (mg/kg/day) % aPAD Exposure (mg/kg/day) % aPAD

Metiram

Females 13-49 years old, Food Only 0.01 0.000169 1.7 0.000654 6.5 0.00193 19

ETU

Females 13-49 years old, Food Only 0.005 0.000066 1.3 0.000138 2.8 0.000299 6.0

Females 13-49 years old,

Food and Water 0.005 0.001242 25 0.00199 40 0.003511 70



## The results indicate that dietary risk estimates for metiram and ETU are not of concern for the population subgroup of concern, females 13-49 years old.

Results of Chronic Dietary Exposure Analysis Chronic assessments were conducted for metiram and ETU and are presented in Table 3 for metiram, and Table 4 for ETU.

Table 3. Results of Chronic Diet ary Exposure Analysis for Metiram Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) % cPAD

General U.S. Population 0.0004 0.000048 12 All Infants (< 1 year old) 0.0004 0.000052 13

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## Page 9 of 62 Table 3. Results of Chronic Diet ary Exposure Analysis for Metiram Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) % cPAD

Children 1-2 years old 0.0004 0.000281 70 Children 3-5 years old 0.0004 0.000163 41 Children 6-12 years old 0.0004 0.000063 16 Youth 13-19 years old 0.0004 0.000022 5.4 Adults 20-49 years old 0.0004 0.000028 6.9 Adults 50+ years old 0.0004 0.000039 9.7 Females 13-49 years old 0.0004 0.000030 7.4

Table 4. Results of Chronic Dietary Exposure Analysis for ETU from Metiram

Population Subgroup cPAD (mg/kg/day) ETU – Food Only ETU – Food and Water Exposure (mg/kg/day) % cPAD Exposure (mg/kg/day) % cPAD

General U.S. Population 0.0002 0.000018 9 0.000022 11 All Infants (< 1 year old) 0.0002 0.000051 25 0.000065 33 Children 1-2 years old 0.0002 0.0001 50 0.000107 54 Children 3-5 years old 0.0002 0.000056 28 0.000063 31 Children 6-12 years old 0.0002 0.000022 11 0.000027 13 Youth 13-19 years old 0.0002 0.000008 3.8 0.000011 5.4 Adults 20-49 years old 0.0002 0.00001 5.1 0.000014 7.1 Adults 50+ years old 0.0002 0.000015 7.6 0.000020 9.8 Females 13-49 years old 0.0002 0.000011 5.3 0.000015 7.4 ** The values for the highest exposed population for each type of risk assessment are bolded.



## The results indicate that chronic dietary risk estimat es for metiram and ETU are not of concern for the all population subgroups.

Results of Cancer Dietary Exposure Analysis Exposure and risk estimates for the ETU cancer assessment are presented in Table 5. Because of the uncertainties regarding estimation of cancer potency and human exposure, risk estimates ranging from 1 to 3 x10 -6 

## are generally considered indistinguishable. The estimated cancer risk for food alone and aggregated food and water are within this range and are not of concern.

Table 5. Results of Cancer Dietary Ex posure Analysis for ETU from Metiram

Population Subgroup Exposure (mg/kg/day) Estimated Cancer Risk

General U.S. Population – Food Only 0.000018 1.1 x 10 -6



### General U.S. Population – Food and Water 0.000022 1.4 x 10 -6

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## Page 10 of 62 VII. Characterization of Inputs/Outputs

The exposure assessments can be considered somewhat refined, as some inputs are conservative, while others can be considered highly refined.

• Field trial data were used for apples, bananas, and grapes. These data are generally considered to be conservative as samples are taken directly from the field and do not reflect any weathering that may occur during packaging and shipping. They also reflect the maximum use rates on the product label; typical use rates may be lower.

• Market basket survey (MBS) data were used for potatoes. The analytical method used to measure residues of EBDC fungicides cannot distinguish between mancozeb, maneb, and metiram, which are all registered for use on potatoes. For this assessment HED assumed all of the EBDC residues found were from metiram, so these estimates are considered an overestimate.

• Percent crop treated data were used for apples and potatoes.

• Percent crop treated information are not available for imported grapes, grape products, and bananas. HED used percent imported data, so it was assumed that all bananas and grapes imported in the US have been treated with metiram. It is unlikely that all of these imported commodities have been treated.

• Consumer practice processing factors for procedur es such as washing and cooking are available and were incorporated into the assessment, providing more refined exposure estimates.

• Residue estimates were refined using factors reflecting commercial processing, such as wine production.

• Estimates of residues in wine were determined by applying processing factors to grape field trial data. Monitoring studies for the other EBDC fungicides on domestic wine generally found much lower residues than the estimates used in this assessment.

VIII. Conclusions

The probabilistic acute and chronic dietary risk assessments were conducted for all supported metiram food uses and the proposed import tolerance bananas and grapes. For metiram, the acute risk estimates are below the Agency’s level of concern at the 99.9 th 

## exposure percentile for females 13-49 years old, the population subgroup of concern (19% of the a PAD). Acute risk estimates for females 13-49 years old are also below HED’s level of concern for ETU with 70% of the aPAD occupied for food and water. The chronic risk estimates are below the Agency’s level of concern for metiram and ETU for the general U.S. population and all population subgroups. The most highly exposed population subgroup is children ages 1-2 with an estimate for metiram for food alone is 70% of the cPAD. For ETU from metiram sources, the estimate for children ages 12 is at 50% of the cPAD for food alone, and 54% for food and water combined. The cancer risk estimate associated with exposure to ETU from metiram is 1.4 x 10 -6 

## for the general U.S. population, and is below the Agency’s level of concern.

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## Page 11 of 62 VIII. List of Attachments

Attachment 1: Estimation of Anticipated Residues for Proposed New Tolerances Attachment 2: Anticipated Residue Summary a nd Residue Distribution Files for Existing Uses Attachment 3: Screening Level Usage Analysis for Existing Uses of Metiram Attachment 4: BEAD Memo on Percent Imported for Bananas and Grapes Attachment 5: Residue Input File – Metiram Acute Analysis – Food Only Attachment 6: Residue Input File – Metiram Chronic Analysis – Food Only Attachment 7: Results File – Metiram Acute Analysis – Food Only Attachment 8: Results File Metiram Chronic Analysis – Food Only Attachment 9: Residue Input File – ETU Acute Analysis – Food Only Attachment 10: Residue Input File – ETU Acute Analysis – Food and Water Attachment 11: Residue Input File – ETU Chronic Analysis – Food Only Attachment 12: Residue Input File – ETU Chronic Analysis – Food and Water Attachment 13: Results File – ETU Acute Analysis – Food Only Attachment 14: Results File – ETU Acute Analysis – Food and Water Attachment 15: Results File – ETU Chronic Analysis – Food Only Attachment 16: Results File – ETU Chronic Analysis – Food and Water Attachment 17: Results File – ETU Cancer Analysis – Food Only Attachment 18: Results File – ETU Cancer Analysis – Food and Water

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## Page 12 of 62 Attachment 1: Estimation of Anticipa ted Residues for Proposed New Tolerances

Crop field trial data were used to estimate anticipated residues for the proposed new tolerances on imported bananas and grapes. A detailed discussion of the data used may be found in the residue chemistry summary document (C. Olinger, DP Number 322230, in review). Processing factors for grape processed products were derived from processing studies submitted in association with the petition. Additionally, processing factors for consumer prac tices such as washing and cooking were used (Reregistration of Mancozeb, Maneb, and Metiram : Processing and Cooking Factors to be Used in the Dietary Risk Assessment”, C. Olinge r, 11/5/2003, DP Numbers 289569; 289570; 289571).

Calculation of Residue Estimates Metiram residues in the raw agricultural commodity were multiplied by relevant processing factors to obtain the estimate of residues in the food as c onsumed. Ethylenethiourea (ETU) residues in/on raw agricultural commodities (RAC) were adjusted for pr ocessing factors. In addition, approximately 7.5% of the metiram consumed converts to ETU in the body; this metabolic ETU must be considered when estimating ETU exposure through food. Total ETU residues in foods consist of ETU in the raw or processed commodities plus the metabolic ETU from parent EBDC. EBDCs may also be converted to ETU during processing, usually when the process involves heating. Below are the formulae used to calculate ETU residue estimates, including both conversion during processing as well as the metabolic ETU:

Raw Agricultural Commodities: [ETU]AR = [ETU]RAC + ([EBDC]RAC X 0.075 X PF1) where [ETU]AR = ETU anticipated residue estimate [ETU]RAC = ETU concentration as measured in the RAC [EBDC]RAC = EBDC concentration as measured in the RAC 0.075 = metabolic conversion factor PF1 = consumer processing factor (such as peeling, washing, trimming)

Processed Commodities: [ETU]AR = ([ETU]RAC X PF2) + ([EBDC ]RAC X 0.075 X PF3) + ([EBDC]RAC X CF) where [ETU]AR = ETU anticipated residue estimate [ETU]RAC = ETU concentration as measured in the RAC PF2 = ETU processing factor (e.g. cooking) [EBDC]RAC = EBDC concentration as measured in the RAC 0.075 = metabolic conversion factor PF3 = processing factor (such as peeling, washing, trimming, cooking) CF = conversion factor for conversion of EBDC to ETU

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## Page 13 of 62

Sample Calculation: Given a raw cucumber sample bearing EBDC residues of 0.17 ppm and ETU residues of 0.02 ppm; EBDC Cooking Factor is 0.0114, ETU cooking factor is 0.87, EBDC to ETU Conversion Factor is 5.3%, and the in vivo metabolic conversion factor is 7.5 %.

EBDC Residues in Cooked Cucumber: [EBDC] raw 

### x CF = [EBDC] cooked 

### 0.17 ppm x 0.114 = 0.005 ppm

Total ETU Residues in Cooked Cucumber [ETU] AR 

### = ([ETU] RAC 

### X PF2) + ([EBDC] RAC 

### X 0.075 X PF3) + ([EBDC] RAC 

### X CF)

Loss of ETU Residues from Cooking ([ETU] RAC 

### X PF2) 0.02 ppm * 0.87 = 0.017 ppm

In vivo Conversion of EBDC residues in cooked commodity to ETU ([EBDC] RAC 

### X 0.075 X PF3) 0.17 ppm * 0.075 * 0.0114 = 0.00014

Conversion of Raw EBDC residues in Raw commodity to ETU during cooking [EBDC] RAC 

### X CF 0.17 ppm * 0.053 = 0.0089

Total ETU Residues = 0.017 + 0.00014 + 0.0089 = 0.026 ppm



## Summary Tables The tables on the following pages provide a summary of the anticipated residues used in the dietary exposure assessment.Metiram Dietary Exposure Assessment DP Number: 326753PC Code: 014601Page 14 of 62Table 1-1. Metiram Anticipated Residues for Proposed Import TolerancesCropField Trial orMonitoring DataPercentImportedAverageResidue Value,ppm2ChronicAnticipatedResidue, ppm3CommodityProcessingFactorResidue Data FileDistribution or AcuteAnticipated Residue4Bananas FT 100 0.050.05 Pulp 1RDF – Bananas0.003 Cooked, cooked pulp 0.060.0135 Dried Pulp 0.27 0.01350.00081 Dried, cooked Pulp 0.0162 0.00081Grapes FT441.630.0863 Washed 0.12RDF - Grapes44 0.00518 Cooked 0.00724450.285 Washed, Dried 0.3964450.0171 Washed, dried, cooked 0.023820 0.327 Wine, uncooked 0.120 0.00196 Wine, cooked 0.0064450.0719 Juice 0.14450.00432 Juice, cooked 0.006Footnotes:1Percent imported obtained from BEAD Quantitative Projected Percent Crop Treated by Jihad Alsadek, dated August 11, 20062Average value from data sourceused for anticipated residue.3Chronic Anticipated Residue value includes correction for percent croptreated and processing.4RDF files are used for partially blended or non-blended commodities and are uncorrected for percent crop treated or processing. Anticipated residues forblended commodities ARE corrected forpercent crop treated and processing.5Percent imported values specific to juice and raisins were not available at the timeof the review, so the percent crop treated for fresh grapes was used.Metiram Dietary Exposure Assessment DP Number: 326753PC Code: 014601Page 15 of 62Table 1-2. Anticipated Residues for Residues ofETU from Metiram Proposed Import TolerancesCropField Trial orMonitoring DataPercentImportedAverage ResidueValue, ppm2ChronicAnticipatedResidue, ppm3CommodityResidue Data FileDistribution or AcuteAnticipated Residue4Bananas FT 1000.0313 0.0313 Pulp RDF – Uncooked Banana0.0236 0.0236 Cooked, cookedpulp RDF – Cooked Banana0.0282 0.0282 Dried Pulp 0.02820.0236 0.0236 Dried,cooked Pulp 0.0236Grapes FT44 0.0352 0.0155 Washed RDF – washed grape44 0.0262 0.0115 Cooked RDF – cooked grape4450.069 0.0304 Washed, Dried RDF – raisins4450.0211 0.00928 Washed, dried,cooked RDF – cooked raisins20 0.0327 0.00654 Wine, uncooked RDF – wine20 0.0189 0.00378 Wine, cooked RDF – cooked wine4450.0327 0.0144 Juice RDF – Grape Juice4450.0189 0.00832 Juice, cooked RDF - GrapeFootnotes:1Percent imported obtained from BEAD Quantitative Projected Percent Crop Treated by Jihad Alsadek, dated August 11, 20062Average value from data sourceused for anticipated residue.3Chronic Anticipated Residue value includes correction for percent croptreated and processing.4RDF files are used for partially blended or non-blended commodities and are uncorrected for percent crop treated or processing. Anticipated residues forblended commodities ARE corrected for percent crop treated and processing.5Percent imported values specific to juice and raisins were not available at the timeof the review, so the percent crop treated for fresh grapes was used.Metiram Dietary Exposure Assessment DP Number: 326753PC Code: 014601Page 16 of 62Table 1-3. New Residue Data files for the Acute Dietary AnalysisMetiram – GrapesGrapes44% CTTOTALZ=37TOTALNZ=290.36 0.61 3.02 0.41 1.86 1.410.77 3.23 0.85 1.47 1.4 0.861.32 1.95 0.75 1.73 1.78 2.692.84 1.1 2.2 1.8 2.4 2 3.1 0.60.6 1.8 2.5Metiram – Wine GrapesWine Grapes20% CTTOTALZ=116TOTALNZ=290.36 0.61 3.02 0.41 1.86 1.410.77 3.23 0.85 1.47 1.4 0.861.32 1.95 0.75 1.73 1.78 2.692.84 1.1 2.2 1.8 2.4 2 3.1 0.60.6 1.8 2.5Metiram – BananasBananas100% CTTOTALZ=0TOTALNZ=240.025 0.09 0.05 0.08 0.025 0.050.025 0.11 0.05 0.14 0.05 0.20.025 0.05 0.025 0.05 0.0250.07 0.05 0.05 0.025 0.0250.025 0.025ETU – Uncooked GrapesETU from Metiram - cooked Grapes44% CTTOTALZ=37TOTALNZ=290.00824 0.0105 0.0392 0.008690.0217 0.0177 0.0119 0.07910.0327 0.0382 0.0376 0.03270.0369 0.0426 0.0318 0.04060.0300 0.0462 0.0406 0.03490.0448 0.0412 0.0466 0.0430.0529 0.0304 0.0304 0.04120.0475ETU – Cooked GrapesETU from Metiram - cooked Grapes44% CTTOTALZ=37TOTALNZ=290.0062 0.00749 0.026 0.006460.0139 0.0116 0.00831 0.06010.0261 0.0293 0.0289 0.02620.0285 0.0318 0.0256 0.03060.0213 0.033 0.0276 0.02740.0330 0.0310 0.0341 0.03200.0377 0.0248 0.0248 0.03100.0346ETU – Uncooked WineETU from Metiram - uncooked wine20% CTTOTALZ=116TOTALNZ=290.0077 0.00958 0.0347 0.008080.019 0.0156 0.0108 0.07420.0314 0.0360 0.0355 0.03140.0349 0.0396 0.0306 0.0380.0274 0.0422 0.0363 0.03320.0415 0.0385 0.043 0.04 0.04820.0295 0.0295 0.0385 0.0438ETU – Cooked WineETU from Metiram - cooked wine20% CTTOTALZ=116TOTALNZ=290.00459 0.00476 0.0125 0.004630.00561 0.00531 0.00487 0.04570.0223 0.0227 0.0227 0.02230.0226 0.0231 0.0223 0.02290.0134 0.021 0.015 0.02250.0232 0.023 0.0234 0.02310.0239 0.0222 0.0222 0.0230.0234ETU – Uncooked JuiceETU from Metiram - uncooked juice44% CTTOTALZ=37TOTALNZ=290.0077 0.00958 0.0347 0.008080.019 0.0156 0.0108 0.07420.0314 0.0360 0.0355 0.03140.0349 0.0396 0.0306 0.0380.0274 0.0422 0.0363 0.03320.0415 0.0385 0.043 0.04 0.04820.0295 0.0295 0.0385 0.0438ETU – Cooked JuiceETU from Metiram - cooked juice44% CTTOTALZ=37TOTALNZ=290.00459 0.00476 0.0125 0.004630.00561 0.00531 0.00487 0.04570.0223 0.0227 0.0227 0.02230.0226 0.0231 0.0223 0.02290.0134 0.021 0.015 0.02250.0232 0.023 0.0234 0.02310.0239 0.0222 0.0222 0.0230.0234ETU – Uncooked RaisinsETU from Metiram - uncooked raisins44% CTTOTALZ=37TOTALNZ=290.0157 0.0231 0.102 0.01720.0602 0.0469 0.0279 0.1460.0502 0.0687 0.0666 0.05050.0642 0.0829 0.0473 0.07640.0669 0.102 0.0993 0.05770.0903 0.0785 0.0963 0.08440.117 0.0428 0.0428 0.07850.0992ETU – Cooked RaisinsETU from Metiram - cooked raisins44% CTTOTALZ=37TOTALNZ=290.00508 0.00558 0.0165 0.005180.00811 0.0072 0.005910.0500278 0.0235 0.0247 0.02460.0235 0.0244 0.026 0.02330.0253 0.0158 0.0246 0.01880.024 0.0262 0.0254 0.02660.0258 0.0280 0.023 0.0230.0254 0.0268ETU – Uncooked BananaETU from Metiram - Uncooked100% CTTOTALZ=0TOTALNZ=240.0268 0.0318 0.0288 0.0310.0269 0.0288 0.0269 0.03320.0288 0.0605 0.0288 0.0650.0269 0.0288 0.0269 0.02880.0269 0.0302 0.0288 0.02880.0269 0.0269 0.0269 0.0269ETU – Cooked BananaMetiram Dietary Exposure Assessment DP Number: 326753PC Code: 014601Page 17 of 62Table 1-3. New Residue Data files for the Acute Dietary AnalysisETU from Metiram - cooked100% CTTOTALZ=0TOTALNZ=240.0219 0.0224 0.0221 0.0223 0.02190.0221 0.0219 0.0225 0.02210.0444 0.0221 0.0449 0.0219 0.02210.0219 0.0221 0.0219 0.02220.0221 0.0221 0.02190.0219 0.0219 0.0219Metiram Dietary Exposure Assessment DP Number: 326753PC Code: 014601Page 18 of 62Attachment 2: Anticipated Residue Summary and Residue Distribution Files for Existing UsesAnticipated Residue Summary for Existing Uses of MetiramCommodityDataSource2DEEM FoodFormBlendedClassification2Metiram ETU% CTProcessingFactorAnticipated Residue(ppm) or RDF3#EBDC toETUConversionProcessingFactorAnticipated Residue(ppm) or RDF #Chronic/CancerAcuteChronic/CancerAcute Avg. MaxPotato, chipsPotatoMBS dataCooked B0.045 Cookingand Chips)0.0034 0.00034 0.045 0.053 0.0003 0.000031 10 10Potato, dry(granules/flakes)PotatoMBS dataCooked B0.102 (cookingand flake)0.0034 0.00034 1.85 (flake) 0.87 0.01 0.000867 10 10Potato, dry(granules/flakes)-babyfoodPotatoMBS dataCooked B0.102 (cookingand flake)0.0034 0.00034 1.85 (flake) 0.87 0.01 0.000867 10 10Potato, flourPotatoMBS dataUncooked B 3.4 (flake) 0.0034 0.00034 1.85(flake) 1 0.0087 0.000986 10 10Cooked B0.102 (Cookingand Flake)0.0034 0.00034 1.85 (flake) 0.87 0.01 0.000986 10 10Potato, flour -babyfoodPotatoMBS dataUncooked B 3.4 (flake) 0.0034 0.00034 1.85 (flake) 1 0.0087 0.000986 10 10Cooked B0.102 (Cookingand Flake)0.0034 0.00034 1.85 (flake) 0.87 0.01 0.000867 10 10Potato, tuberw/peelPotatoMBS dataCooked NB0.011 (Washing/cooking)0.0034RDF #1 0.053 0.87 0.0033 RDF #1 10 10Potato, tuberw/peel-babyfoodPotatoMBS dataCooked PB0.011 (Washing/cooking)0.0034 RDF #1 0.053 0.87 0.0033 RDF #1 10 10Potato, tuber w/opeelPotatoMBS dataUncooked NB0.14 (Washing/peeling)0.0034 RDF #1 N/A 1 0.0027 RDF #1 10 10Cooked:FreshCooked:DriedCooked:CannedCooked:CuredPB0.0042(Washing/peeling/ cooking)0.0034 RDF #10.053 0.87 0.0033 RDF #7 10 10Cooked:FrozenPB0.0042(Washing/peeling/ cooking)0.0028 RDF #4Potato, tuber w/opeel-babyfoodPotatoMBS dataCooked:CannedPB0.0042(Washing/peeling/ cooking)0.0034 RDF #1 0.053 0.87 0.0027 RDF #1 10 10Metiram Dietary Exposure Assessment DP Number: 326753PC Code: 014601Page 19 of 62Anticipated Residue Summary for Existing Uses of MetiramCommodityDataSource2DEEM FoodFormBlendedClassification2Metiram ETU% CTProcessingFactorAnticipated Residue(ppm) or RDF3#EBDC toETUConversionProcessingFactorAnticipated Residue(ppm) or RDF #Chronic/CancerAcuteChronic/CancerAcute Avg. MaxApple, fruit withpeelApple FTUncooked NB 0.41 (Washing)0.242 RDF # 2N/A 1 0.01 RDF # 315 25Cooked NB0.025 (Washingand Cooking)0.0023(Cooking)0.87(Cooking)0.0037 RDF # 2Apple, peeledfruitApple FT Uncooked NB 0.41(Washing/) 0.242 RDF # 2 N/A 1 0.01 RDF # 3 15 25Apple FTCooked,FreshCooked,FrozenCooked,Dried,Cooked,CannedNB/PB0.025 (Washingand Cooking)0.242 RDF # 20.0023(Cooking)0.87(Cooking)0.0037 RDF # 2 15 25Apple, peeledfruit-babyfoodApple FTCooked,CannedPB0.025 (Washingand Cooking)0.242 RDF # 20.0023(Cooking)0.87(Cooking)0.0037 RDF # 2 15 25Apples-dried Apple FTUncooked B0.11(Washing/drying)0.242 0.0605N/A 1 0.01 0.002615 25Cooked B0.0066(Washing,dryingand Cooking)0.0023(Cooking)0.87(Cooking)0.0037 0.00026Apple, driedbabyfoodApple FT Cooked B0.0066(Washing. Dryingand Cooking)0.242 0.06050.0023(Cooking)0.87(Cooking)0.0037 0.000915 25Apples-juice Apple FTUncooked PB0.041 ( Washingand Juicing)0.242 RDF # 20.0046(Juice)1 0.0049 RDF # 5Cooked PB0.0025 (washing,Cooking andJuicing)0.0046(Juice)0.87(Cooking)0.0038 RDF # 4 15 25Apples, juicebabyfoodApple FT Cooked PB0.0025(Washing,Cooking andJuicing)0.242 RDF # 20.0046(Juice)0.87(Cooking)0.0038 RDF # 4 15 25Apple, sauce Apple FTUncooked NB0.41 (Washingand Cooking)0.242 RDF # 2N/A 1 0.01 RDF # 3 15 25Cooked NB0.025 (Washingand Cooking)0.0023(Cooking)0.87(Cooking)0.0037 RDF # 2 15 25Metiram Dietary Exposure Assessment DP Number: 326753PC Code: 014601Page 20 of 62Anticipated Residue Summary for Existing Uses of MetiramCommodityDataSource2DEEM FoodFormBlendedClassification2Metiram ETU% CTProcessingFactorAnticipated Residue(ppm) or RDF3#EBDC toETUConversionProcessingFactorAnticipated Residue(ppm) or RDF #Chronic/CancerAcuteChronic/CancerAcute Avg. MaxApple, saucebabyfoodApple FTCooked,CannedPB0.025 (Washingand Cooking)0.242 RDF # 20.0023(Cooking)0.87(Cooking)0.0037 RDF # 21. FT = Field trial; MBS = EBDC Market Basket Survey2. PB = Partially blended; B = Blended; NB = Not Blended3. RDF = Residue Distribution File

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 21 of 62 Metiram RDF Files – Existing Uses

PotatoMBS.rdf Potato Raw, UNW 10 %CT TotalZ=315 TotalNZ=7 28, 0.0025 0.0054 0.0192 0.0106 0.007 0.0268 0.005 0.2328 Apple.rdf Metiram - Apples 25 % CT Totalz=69 Totalnz = 23 0.1633 0.1081 0.0159 0.015 0.2095 0.0609 0.2872 0.2365 0.1971 0.3744 0.0251 0.1036 0.1391 0.0351 0.5236 0.1265 0.5126 0.0557 0.437 0.5062 0.1959 0.1959 1.0504 Potato

Potato, Frozen Raw, UNW 10%CT TotalZ=225 TotalNZ=5 20, 0.0028 0.0052 0.0060 0.0055 0.0052 0.0075



### ETU RDF Files – Existing Uses

AppleuncookedETU.rdf

Apple - Uncooked -FT 25% CT TOTALZ=69 TOTALNZ=23 0.0075 0.0058 0.0030 0.0030 0.0089 0.0044 0.0113 0.0098 0.0086 0.0140 0.0033 0.0057 0.0068 0.0036 0.0224 0.0064 0.0183 0.0042 0.0159 0.0181 0.0085 0.0085 0.0443 ApplecookedETU.rdf

Apple - Cooked - FT 25% CT TOTALZ=69 TOTALNZ=23 0.0029 0.0026 0.0022 0.0022 0.003 0.0024 0.0034 0.0032 0.003 0.0037 0.0023 0.0026 0.0028 0.0023 0.0077 0.0027 0.0043 0.0024 0.004 0.0043 0.003 0.003 0.0148 ApplejuiceuncookedETU.rdf

Apple Juice - UNCOOKED - FT 25% CT TOTALZ=69 TOTALNZ=23 0.0038 0.0033 0.0026 0.0026 0.0041 0.0030 0.0047 0.0043 0.0040 0.0054 0.0027 0.0033 0.0036 0.0028 0.0103 0.0035 0.0064 0.0029 0.0059 0.0064 0.0040 0.0040 0.0201 ApplejuicecookedETU.rdf

Apple Juice - COOKED - FT 25% CT TOTALZ=69 TOTALNZ=23 0.0030 0.0027 0.0023 0.0022 0.0032 0.0025 0.0035 0.0033 0.0031 0.0040 0.0023 0.0027 0.0028 0.0023 0.0080 0.0028 0.0046 0.0024 0.0043 0.0046 0.0031 0.0031 0.0155

PotatoETUuncookedMBS.rdf Potato- MBS Uncooked 10% CT TOTALZ=0 TOTALNZ=110 206, 0.0010 0.0076 0.0021 0.001 0.0117 0.006 0.0063 0.0041 0.0023 0.002 0.0128 0.0034 0.0027 0.0022 0.0044 0.0044 0.0058 0.0054 0.0026 0.0025 0.0106 0.0051 0.0054 0.0088 0.0036 0.0033 0.0073 0.0047 0.002 0.0054 0.0036 0.0032 0.0029 0.0022 0.0028 0.0037 0.0026 0.003 0.0024 0.0039 0.0034 0.002 0.0128 0.0101 0.004 0.002 0.0075 0.0036 0.0045 0.002 0.002 0.007 0.0022 0.0096 0.0034 0.0072 0.0021 0.0021 0.0161 0.0044 0.0105 0.004 0.0024 0.0072 0.0084 0.0062 0.0255 0.0098 0.002 0.0044 0.0088 0.0035 0.0031 0.0044 0.0104 0.0046 0.0037 0.0055 0.0026 0.0452 0.0036 0.0037 0.0013 0.008 0.0034 0.0052 0.0058 0.0038 0.0038 0.0104 0.003 0.0052 0.0328 0.0092 0.002 0.0042 0.0126 0.0028 0.0107 0.0039 0.0062 0.0105 0.002 0.003 0.0038 0.0034 0.0026 0.0038 0.0023 0.0058 0.0093 PotatoETUCookedMBS.rdf Potato-MBS cooked 10% CT TOTALZ=0 TOTALNZ=110 206, 0.0010 0.0069 0.0021 0.0020 0.0104 0.0055 0.0057 0.0038 0.0023 0.0020 0.0113 0.0032 0.0026 0.0022 0.0047 0.0041 0.0053 0.0050 0.0025 0.0024 0.0095 0.0047 0.0050 0.0079 0.0034 0.0034 0.0066 0.0044 0.0020 0.0050 0.0034 0.0031 0.0028 0.0022 .0027 0.0035 0.0025 0.0029 0.0024 0.0037 0.0032 0.0020 0.0114 0.0090 0.0037 0.0020 0.0068 0.0034 0.0042 0.0020 0.0020 0.0064 0.0022 0.0086 .0032 0.0065 0.0021 0.0021 0.0143 0.0041 0.0094 0.0037 0.0024 0.0065 0.0076 0.0057 0.0225 0.0088 0.0011 0.0041 0.0079 0.0033 0.0030 0.0041 .0093 0.0043 0.0035 0.0051 0.0025 0.0396 0.0034 0.0035 0.0023 0.0072 0.0032 0.0048 0.0053 0.0036 0.0036 0.0093 0.0029 0.0048 0.0288 0.0083 .0020 0.0039 0.0112 0.0027 0.0096 0.0037 0.0057 0.0094 0.0020 0.0029 0.0036 0.0134 0.0025 0.0036 0.0023 0.0053 0.0084

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 22 of 62 Attachment 3: Screening Level Usage Analysis for Existing Uses of Metiram

Tuesday, March 22, 2005 Screening Level Estimates of Agricultural Uses of Metiram Sorted Alphabetically

**Crop Lbs. A.I. Percent Crop Ttd**

. Avg. Max. 1 Apples 500,000 15 25 2 Asparagus 1,000 <1 <2.5 3 Peaches 2,000 <1 <2.5 4 Pears <500 <1 <2.5 5 Potatoes 400,000 10 10 6 Squash <500 <1 <2.5

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 23 of 62 Attachment 4: BEAD Memo on Percent Imported for Bananas and Grapes

MEMORANDUM

SUBJECT: Projected Percent Crop Treated (PPCT) for Fungicide Mancozeb (PC 14504) on Five Crops (DP 330013), and Import Shares for Two Crops (DP 330015)

FROM: Jihad Alsadek, Ph.D., Economist Science Information & Analysis Branch Biological and Economic Analysis Division (7503P)

TO: Mary Waller MUIERB Registration Division (7505P)

I. SUMMARY

This memorandum provides average and maximum projected percent crop treated (PPCT) numbers for five new mancozeb uses (almonds, broccoli, cabbage, lettuce, and peppers), and import shares for grapes and bananas. In addition, it provides the suggested Federal Register (FR) language. Tabulated biological justifica tions/comments in Table 1, provided by Richard Michell, plant pathologist with BEAD, give both explanations for these PPCTs as well as background for the proposed FR language. The estimated PPCTs and the corresponding methodology for the five crops, together with estimated import shares, are given in Table 2. BEAD has determined that there are no factors that clearly indicate that the actual PCTs for mancozeb on almonds, broccoli, cabbage, lettuce, and peppers in the next five years will exceed the estimated PPCT provided for mancozeb on these crops. Below is the recommended boilerplate FR language, as well as the tabulated background information on all five crops. This memorandum has been reviewed by Alan Halvorson, an economist with BEAD.

II. FR LANGUAGE

EPA estimates PPCT for a new pesticide use by assuming that the percent crop treated (PCT) during the pesticide’s initial five years of use on a specific use site will not exceed the average PCT of the market leader (i.e., the one w ith the greatest PCT) on that site over the three most recent surveys. Comparisons are only made among pesticides of the same pesticide types [i.e., the dominant fungicide(s) on the use site is selected for comparison with the new fungicide(s)]. The PCTs included in the average may be each for the same pesticide or for different pesticides since the same or different pesticides may dominate for each year selected. Typically, EPA uses USDA/NASS as the source for the PCT data because they are publicly available. When a specific use site is not surveyed by USDA/NASS, EPA uses proprietary data

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## Page 24 of 62 and calculates the estimated PCT.

This estimated PPCT, based on the average PCT of the market leader, is appropriate for use in the chronic dietary risk assessment. This method of estimating a PPCT for a new use of a registered pesticide or a new pesticide produces a high-end estimate that is unlikely, in most cases, to be exceeded during the initial five years of actual use. The predominant factors that generally can be analyzed based on readily available information and that bear on whether the PPCT could be exceeded are whether there are concerns with pest pressures as indicated in emergency exemption requests or other readily available information, whether the new pesticide controls a broader spectrum of pests than the market leader pesticide(s) and/or whether the new pesticide has a shorter post-harvest interval (PHI).

All such relevant information currently available has been considered for mancozeb on almonds, broccoli, cabbage, lettuce, and peppers, and it is unlikely that actual PCT for mancozeb will exceed the estimated PPCT for mancozeb on each of these five crops during the next five years mainly because mancozeb and its counterpart maneb have both been registered on a wide range of crops for many years and are considered to have comparable pest spectra and efficacy. Accordingly, based on maneb’s labeled pests, mancozeb may also provide control of almond scab, almond anthracnose, almond leaf rust, and lettuce anthracnose, downy mildew of cabbage and broccoli, and bacterial spot and cercospora leaf spot of peppers. If mancozeb is used for any of these non-labeled pests it would still be competing for market share with maneb and possibly other fungicides.

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 25 of 62 TABLE 1

CURSORY BIOLOGICAL ANALYSIS OF BEAD’S PROJECTED PERCENT CROP TREATED (PPCT) FOR MANCOZEB ON FIVE NEW CROPS

NEW USES

[AVG. /MAX. PPCT] RECENT MARKET LEADER(S) [SAMPLE YEARS] JUSTIFICATION/COMMENTS WILL MANCOZEB EXCEED THE PPCT LEVELS OF RECENT MARKET LEADER(S)? ALMONDS – SHOTHOLE, BROWN ROT [35/35] IPRODIONE [1999] iprodione and some of the other alternatives reportedly possess equal or better efficacy than mancozeb’s counterpart maneb, which has a much lower pct than iprodione NO

BROCCOLI - ALTERNARIA [7/9] MEFANOXAM [2000, 2002, 2004] mefanoxam does not control the target pest (alternaria), but is used principally for control of downy mildew, which is a more prevalent pest problem than alternaria; mancozeb is expected to split the market with its counterpart maneb, which had less usage than the market leaders NO

CHLOROTHALONIL [2000, 2002, 2004] chlorothalonil is used to control the target pest (alternaria) plus downy mildew, which is a more prevalent pest problem than alternaria; mancozeb is expected to split the market with its counterpart maneb, which had less usage than the market leaders

CABBAGE - ALTERNARIA [42/47-FRESH; 10/18- PROCESSED] CHLOROTHALONIL [FRESH:2000, 2002, 2004; PROCESSED: 1996, 1998, 2000] chlorothalonil is used for control of the target pest (alternaria) plus downy mildew, which is a more prevalent pest problem than alternaria; mancozeb is expected to split the market with its counterpart maneb, which had less usage than the market leader NO

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## Page 26 of 62 NEW USES

[AVG. /MAX. PPCT] RECENT MARKET LEADER(S) [SAMPLE YEARS] JUSTIFICATION/COMMENTS WILL MANCOZEB EXCEED THE PPCT LEVELS OF RECENT MARKET LEADER(S)?

LETTUCE – DOWNY MILDEW [58/66] MANEB [2000, 2002, 2004] maneb is used for anthracnose and downy mildew; mancozeb is expected to split the market with its counterpart maneb, which has been a market leader in recent

years NO

FOSETYL-AL [2000, 2002, 2004] fosetyl-al is used principally for downy mildew control, however, it is primarily used as an alternative to maneb, especially just before harvest because it has a much lower PHI and can be applied closer to harvest than maneb; mancozeb will have a PHI limitation similar to maneb; accordingly, mancozeb is only expected to gain a portion of the maneb market.

PEPPERS – ANTHRACNOSE, EARLY BLIGHT, PHOMOPSIS [43/48] SULFUR [2000, 2002, 2004] Sulfur is applied principally for control of powdery mildew; while mancozeb’s counterpart maneb is used for control of frogeye leaf spot, anthracnose & bacterial diseases; mancozeb will only be competing for a portion of maneb’s market share. NO

COPPER HYDROXIDE [2000, 2002, 2004] Copper is applied principally for control of frogeye leaf spot & bacterial diseases; for bacterialdiseases it is often used in tankmixes with mancozeb’s counterpart maneb to enhance copper efficacy; current maneb use is for control of frogeye leaf spot, anthracnose & bacterial diseases; mancozeb will only be competing for a portion of maneb’s market

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 27 of 62 NEW USES

[AVG. /MAX. PPCT] RECENT MARKET LEADER(S) [SAMPLE YEARS] JUSTIFICATION/COMMENTS WILL MANCOZEB EXCEED THE PPCT LEVELS OF RECENT MARKET LEADER(S)? share.

ASSUMPTIONS : mancozeb and its counterpart maneb have both been registered on a wide range of crops for many years and are considered to have comparable pest spectra and efficacy. Accordingly, based on maneb’s labeled pests, mancozeb may also provide control of almond scab, almond anthracnose, almond leaf rust, and lettuce anthracnose, downy mildew of cabbage and broccoli, and bacterial spot and cercospora leaf spot of peppers. If mancozeb is used for any of these non-labeled pests it would still be competing for market share with maneb and possibly other fungicides.

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 28 of 62 

# Table 2 Mancozeb Projected Percent Crop treated (PPCT)

Crop Alternative1 Chemical (s) Average2 Market Leader Maximum3 Market Leader Years

Almonds Iprodione 35 35 1999 Broccoli Mefenoxam, Chlorothaloni l 7 9 2000, 2002, 2004

CabbageFresh Chlorothaloni l 42 47 2000, 2002, 2004CabbageProcessed Chlorothaloni l 10 18 1996, 1998, 2000LettuceHead Maneb 58 66 2000, 2002, 2004LettuceOther Maneb, Fosetyl-Al 59 61 2000, 2002, 2004 Peppers-Bell Sulfur, Copper Hydroxide 43 48 2000, 2002, 2004

Sources: Agricultural Chemical Usage, Vegetables Summary (2000, 2002, and 2004). Agricultural Statistics Board NASS, USDA. Agricultural Chemical Usage, Fruits and Nuts Summary (1999). Agricultural Statistics Board NASS, USDA. 

# Import Shares4 for Grapes and Bananas Crop Import Share5 Grapes 44 Bananas6 99

Sources: 1. U.S. Department of Agricultur e and the Census Bureau of the U.S. Department of Commerce. 

### 2. Economic Research Service (ERS), USDA, FAU – 79 – 01, July 2003.



### 1 Alternative chemical could be the same chemical fo r all three years or could be different for each year. 2 Average of the available years. 3 The highest observed percent crop treated. 4 Import share is an average of three years (1999, 2000, and 2001). 

## 5 This is the import share of food consumption



## . 6 Bananas have 100 or close to 100 percent import shares and was excluded from the list of import share table in ERS.

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 29 of 62 Attachment 5: Residue Input File – Metiram Acute Analysis – Food Only Filename: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM Files\Metiram\MetiramAcutePriasept2006.R98 Chemical: Metiram RfD(Chronic): .0004 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .01 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 09-27-2006/14:12:41/8 Program ver. 2.03 Comment: Females 13+ only

-------------------------------------------------------------------------------- RDL indices and parameters for Monte Carlo Analysis: Index Dist Parameter #1 Param #2 Param #3 Comment # Code

----- ---- ------------ -------- -------- ------- 1 6 potatoMBS.rdf 2 6 apple.rdf 3 6 bananas.rdf 4 6 potato frozen MBS.rdf 5 6 GRAPES.RDF 6 6 WINEGRAPES.RDF

EPA Crop Commodity Name Def Res Adj.Factors RDL Comment Code Grp (ppm) #1 #2 Pntr

-------- ---- ------------------------------- ---------- ------ ------ --- ------- 11000070 11 Apple, fruit with peel 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 0.410 1.000 2 washin Full comment: washing factor 150-Uncooked; Cured etc; Cook Meth N/S 1.000000 0.410 1.000 2 washin Full comment: washing factor 211-Cooked; Fresh or N/S; Baked 1.000000 0.025 1.000 2 washin Full comment: washing/cooking 213-Cooked; Fresh or N/S; Fried 1.000000 0.025 1.000 2 washin Full comment: washing/cooking 11000080 11 Apple, peeled fruit 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 0.410 1.000 2 washin Full comment: washing/peeling 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 0.025 1.000 2 washin Full comment: washing/peeling/cooking 211-Cooked; Fresh or N/S; Baked 1.000000 0.025 1.000 2 washin Full comment: washing/peeling/cooking 213-Cooked; Fresh or N/S; Fried 1.000000 0.025 1.000 2 washin Full comment: washing/peeling/cooking 221-Cooked; Frozen; Baked 1.000000 0.025 1.000 2 washin Full comment: washing/peeling/cooking 232-Cooked; Dried; Boiled 1.000000 0.025 1.000 2 washin Full comment: washing/peeling/cooking 240-Cooked; Canned; Cook Meth N/S 1.000000 0.025 1.000 2 washin Full comment: washing/peeling/cooking 11000081 11 Apple, peeled fruit-babyfood 240-Cooked; Canned; Cook Meth N/S 1.000000 0.025 1.000 2 washin Full comment: washing/peeling/cooking 11000090 11 Apple, dried 130-Uncooked; Dried; Cook Meth N/S 0.060500 0.110 1.000 drying Full comment: drying factor 210-Cooked; Fresh or N/S; Cook Meth N/S 0.060500 0.007 1.000 drying Full comment: drying factor 211-Cooked; Fresh or N/S; Baked 0.060500 0.007 1.000 drying Full comment: drying factor

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 30 of 62 230-Cooked; Dried; Cook Meth N/S 0.060500 0.007 1.000 drying Full comment: drying factor 11000091 11 Apple, dried-babyfood 230-Cooked; Dried; Cook Meth N/S 0.060500 0.007 1.000 drying Full comment: drying factor 11000100 11 Apple, juice 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 0.041 1.000 2 juicin Full comment: juicing factor 120-Uncooked; Frozen; Cook Meth N/S 1.000000 0.041 1.000 2 juicin Full comment: juicing factor 130-Uncooked; Dried; Cook Meth N/S 1.000000 0.041 1.000 2 juicin Full comment: juicing factor 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 0.003 1.000 2 juicin Full comment: juicing factor 211-Cooked; Fresh or N/S; Baked 1.000000 0.003 1.000 2 juicin Full comment: juicing factor 212-Cooked; Fresh or N/S; Boiled 1.000000 0.003 1.000 2 juicin Full comment: juicing factor 213-Cooked; Fresh or N/S; Fried 1.000000 0.003 1.000 2 juicin Full comment: juicing factor 214-Cooked; Fresh or N/S; Fried/baked 1.000000 0.003 1.000 2 juicin Full comment: juicing factor 230-Cooked; Dried; Cook Meth N/S 1.000000 0.003 1.000 2 juicin Full comment: juicing factor 240-Cooked; Canned; Cook Meth N/S 1.000000 0.003 1.000 2 juicin Full comment: juicing factor 11000101 11 Apple, juice-babyfood 230-Cooked; Dried; Cook Meth N/S 1.000000 0.003 1.000 2 juicin Full comment: juicing factor 240-Cooked; Canned; Cook Meth N/S 1.000000 0.003 1.000 2 juicin Full comment: juicing factor 11000110 11 Apple, sauce 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 0.410 1.000 2 sauce Full comment: sauce factor 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 0.025 1.000 2 sauce Full comment: sauce factor 211-Cooked; Fresh or N/S; Baked 1.000000 0.025 1.000 2 sauce Full comment: sauce factor 212-Cooked; Fresh or N/S; Boiled 1.000000 0.025 1.000 2 sauce Full comment: sauce factor 221-Cooked; Frozen; Baked 1.000000 0.025 1.000 2 sauce Full comment: sauce factor 240-Cooked; Canned; Cook Meth N/S 1.000000 0.025 1.000 2 sauce Full comment: sauce factor 11000111 11 Apple, sauce-babyfood 240-Cooked; Canned; Cook Meth N/S 1.000000 0.025 1.000 2 sauce Full comment: sauce factor 95000230 O Banana 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 3 120-Uncooked; Frozen; Cook Meth N/S

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 31 of 62 1.000000 1.000 1.000 3 130-Uncooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 3 211-Cooked; Fresh or N/S; Baked 1.000000 0.060 1.000 3 212-Cooked; Fresh or N/S; Boiled 1.000000 0.060 1.000 3 213-Cooked; Fresh or N/S; Fried 1.000000 0.060 1.000 3 223-Cooked; Frozen; Fried 1.000000 0.060 1.000 3 240-Cooked; Canned; Cook Meth N/S 1.000000 0.060 1.000 3 95000231 O Banana-babyfood 211-Cooked; Fresh or N/S; Baked 1.000000 0.060 1.000 3 230-Cooked; Dried; Cook Meth N/S 1.000000 0.060 1.000 3 240-Cooked; Canned; Cook Meth N/S 1.000000 0.060 1.000 3 95000240 O Banana, dried 130-Uncooked; Dried; Cook Meth N/S 0.050000 0.016 1.000 211-Cooked; Fresh or N/S; Baked 0.050000 0.016 1.000 230-Cooked; Dried; Cook Meth N/S 0.050000 0.016 1.000 95000241 O Banana, dried-babyfood 230-Cooked; Dried; Cook Meth N/S 0.050000 0.016 1.000 95001750 O Grape 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 0.120 1.000 5 120-Uncooked; Frozen; Cook Meth N/S 1.000000 0.120 1.000 5 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 0.007 1.000 5 240-Cooked; Canned; Cook Meth N/S 1.000000 0.007 1.000 5 95001760 O Grape, juice 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 0.100 1.000 5 120-Uncooked; Frozen; Cook Meth N/S 1.000000 0.100 1.000 5 130-Uncooked; Dried; Cook Meth N/S 1.000000 0.100 1.000 5 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 0.006 1.000 5 211-Cooked; Fresh or N/S; Baked 1.000000 0.006 1.000 5 221-Cooked; Frozen; Baked 1.000000 0.006 1.000 5 230-Cooked; Dried; Cook Meth N/S 1.000000 0.006 1.000 5 240-Cooked; Canned; Cook Meth N/S 1.000000 0.006 1.000 5 95001761 O Grape, juice-babyfood 240-Cooked; Canned; Cook Meth N/S 1.000000 0.006 1.000 5 95001770 O Grape, leaves 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 0.007 1.000 5 211-Cooked; Fresh or N/S; Baked 1.000000 0.007 1.000 5 95001780 O Grape, raisin 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 0.396 1.000 5 130-Uncooked; Dried; Cook Meth N/S 1.000000 0.396 1.000 5 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 0.024 1.000 5 211-Cooked; Fresh or N/S; Baked 1.000000 0.024 1.000 5

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 32 of 62 212-Cooked; Fresh or N/S; Boiled 1.000000 0.024 1.000 5 213-Cooked; Fresh or N/S; Fried 1.000000 0.024 1.000 5 221-Cooked; Frozen; Baked 1.000000 0.024 1.000 5 230-Cooked; Dried; Cook Meth N/S 1.000000 0.024 1.000 5 232-Cooked; Dried; Boiled 1.000000 0.024 1.000 5 240-Cooked; Canned; Cook Meth N/S 1.000000 0.024 1.000 5 95001790 O Grape, wine and sherry 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 0.100 1.000 6 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 0.006 1.000 6 211-Cooked; Fresh or N/S; Baked 1.000000 0.006 1.000 6 212-Cooked; Fresh or N/S; Boiled 1.000000 0.006 1.000 6 213-Cooked; Fresh or N/S; Fried 1.000000 0.006 1.000 6 221-Cooked; Frozen; Baked 1.000000 0.006 1.000 6 230-Cooked; Dried; Cook Meth N/S 1.000000 0.006 1.000 6 240-Cooked; Canned; Cook Meth N/S 1.000000 0.006 1.000 6 242-Cooked; Canned; Boiled 1.000000 0.006 1.000 6 250-Cooked; Cured etc; Cook Meth N/S 1.000000 0.006 1.000 6 01032960 1C Potato, chips 211-Cooked; Fresh or N/S; Baked 0.000340 0.045 1.000 chips Full comment: chips factor 213-Cooked; Fresh or N/S; Fried 0.000340 0.045 1.000 chips Full comment: chips factor 01032970 1C Potato, dry (granules/ flakes) 211-Cooked; Fresh or N/S; Baked 0.000340 0.102 1.000 flakes Full comment: flakes factor 212-Cooked; Fresh or N/S; Boiled 0.000340 0.102 1.000 flakes Full comment: flakes factor 213-Cooked; Fresh or N/S; Fried 0.000340 0.102 1.000 flakes Full comment: flakes factor 214-Cooked; Fresh or N/S; Fried/baked 0.000340 0.102 1.000 flakes Full comment: flakes factor 221-Cooked; Frozen; Baked 0.000340 0.102 1.000 flakes Full comment: flakes factor 230-Cooked; Dried; Cook Meth N/S 0.000340 0.102 1.000 flakes Full comment: flakes factor 232-Cooked; Dried; Boiled 0.000340 0.102 1.000 flakes Full comment: flakes factor 01032971 1C Potato, dry (granules/ flakes)-b 240-Cooked; Canned; Cook Meth N/S 0.000340 0.102 1.000 flakes Full comment: flakes factor 01032980 1C Potato, flour 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.000340 3.400 1.000 flakes Full comment: flakes factor 120-Uncooked; Frozen; Cook Meth N/S 0.000340 3.400 1.000 flakes Full comment: flakes factor 130-Uncooked; Dried; Cook Meth N/S 0.000340 3.400 1.000 flakes Full comment: flakes factor 210-Cooked; Fresh or N/S; Cook Meth N/S

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 33 of 62 0.000340 0.102 1.000 flakes Full comment: flakes factor 211-Cooked; Fresh or N/S; Baked 0.000340 0.102 1.000 flakes Full comment: flakes factor 212-Cooked; Fresh or N/S; Boiled 0.000340 0.102 1.000 flakes Full comment: flakes factor 213-Cooked; Fresh or N/S; Fried 0.000340 0.102 1.000 flakes Full comment: flakes factor 214-Cooked; Fresh or N/S; Fried/baked 0.000340 0.102 1.000 flakes Full comment: flakes factor 215-Cooked; Fresh or N/S; Boiled/baked 0.000340 0.102 1.000 flakes Full comment: flakes factor 220-Cooked; Frozen; Cook Meth N/S 0.000340 0.102 1.000 flakes Full comment: flakes factor 221-Cooked; Frozen; Baked 0.000340 0.102 1.000 flakes Full comment: flakes factor 222-Cooked; Frozen; Boiled 0.000340 0.102 1.000 flakes Full comment: flakes factor 223-Cooked; Frozen; Fried 0.000340 0.102 1.000 flakes Full comment: flakes factor 230-Cooked; Dried; Cook Meth N/S 0.000340 0.102 1.000 flakes Full comment: flakes factor 231-Cooked; Dried; Baked 0.000340 0.102 1.000 flakes Full comment: flakes factor 232-Cooked; Dried; Boiled 0.000340 0.102 1.000 flakes Full comment: flakes factor 233-Cooked; Dried; Fried 0.000340 0.102 1.000 flakes Full comment: flakes factor 240-Cooked; Canned; Cook Meth N/S 0.000340 0.102 1.000 flakes Full comment: flakes factor 242-Cooked; Canned; Boiled 0.000340 0.102 1.000 flakes Full comment: flakes factor 250-Cooked; Cured etc; Cook Meth N/S 0.000340 0.102 1.000 flakes Full comment: flakes factor 251-Cooked; Cured etc; Baked 0.000340 0.102 1.000 flakes Full comment: flakes factor 252-Cooked; Cured etc; Boiled 0.000340 0.102 1.000 flakes Full comment: flakes factor 253-Cooked; Cured etc; Fried 0.000340 0.102 1.000 flakes Full comment: flakes factor 01032981 1C Potato, flour-babyfood 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.000340 3.400 1.000 flakes Full comment: flakes factor 130-Uncooked; Dried; Cook Meth N/S 0.000340 3.400 1.000 flakes Full comment: flakes factor 240-Cooked; Canned; Cook Meth N/S 0.000340 0.102 1.000 flakes Full comment: flakes factor 01032990 1C Potato, tuber, w/peel 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 0.011 1.000 1 washin Full comment: washing/cooking 211-Cooked; Fresh or N/S; Baked 1.000000 0.011 1.000 1 washin Full comment: washing/cooking 212-Cooked; Fresh or N/S; Boiled 1.000000 0.011 1.000 1 washin Full comment: washing/cooking 213-Cooked; Fresh or N/S; Fried 1.000000 0.011 1.000 1 washin

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 34 of 62 Full comment: washing/cooking 01032991 1C Potato, tuber, w/peel-babyfood 1.000000 0.011 1.000 1 washin Full comment: washing/cooking 01033000 1C Potato, tuber, w/o peel 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 0.140 1.000 1 washin Full comment: washing/peeling 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 0.004 1.000 1 washin Full comment: washing/peeling/cooking 211-Cooked; Fresh or N/S; Baked 1.000000 0.004 1.000 1 washin Full comment: washing/peeling/cooking 212-Cooked; Fresh or N/S; Boiled 1.000000 0.004 1.000 1 washin Full comment: washing/peeling/cooking 213-Cooked; Fresh or N/S; Fried 1.000000 0.004 1.000 1 washin Full comment: washing/peeling/cooking 221-Cooked; Frozen; Baked 1.000000 0.004 1.000 4 washin Full comment: washing/peeling/cooking 223-Cooked; Frozen; Fried 1.000000 0.004 1.000 4 washin Full comment: washing/peeling/cooking 232-Cooked; Dried; Boiled 1.000000 0.004 1.000 1 washin Full comment: washing/peeling/cooking 233-Cooked; Dried; Fried 1.000000 0.004 1.000 1 washin Full comment: washing/peeling/cooking 240-Cooked; Canned; Cook Meth N/S 1.000000 0.004 1.000 1 washin Full comment: washing/peeling/cooking 242-Cooked; Canned; Boiled 1.000000 0.004 1.000 1 washin Full comment: washing/peeling/cooking 252-Cooked; Cured etc; Boiled 1.000000 0.004 1.000 1 washin Full comment: washing/peeling/cooking 253-Cooked; Cured etc; Fried 1.000000 0.004 1.000 1 washin Full comment: washing/peeling/cooking 01033001 1C Potato, tuber, w/o peel-babyfood 240-Cooked; Canned; Cook Meth N/S 1.000000 0.004 1.000 1 washin Full comment: washing/peeling/cooking

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 35 of 62 Attachment 7: Results File – Metiram Acute Analysis – Food Only U.S. Environmental Protection Agency Ver. 2.02 DEEM-FCID ACUTE Analysis for METIRAM (1994-98 data) Residue file: MetiramAcutePriasept2006.R98 Adjustment factor #2 used. Analysis Date: 03-06-2007/15:08:14 Residue file dated: 03-06-2007/15:06:38/8 Daily totals for food and foodform consumption used. MC iterations = 1000 MC list in residue file MC seed = 10 Run Comment: "Females 13+ only"

===============================================================================

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Females 13-49 yrs: 0.000169 1.69 0.000654 6.54 0.001926 19.26

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 36 of 62 Attachment 8: Results File Metiram Chronic Analysis – Food Only U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for METIRAM (1994-98 data) Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM Files\Metiram\MetiramChronicpriasept2006.R98 Adjustment factor #2 used. Analysis Date 09-27-2006/14:19:03 Residue file dated: 09-27-2006/14:18:14/8 Reference dose (RfD, Chronic) = .0004 mg/kg bw/day COMMENT 1: Females 13+ only

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.000048 12.0%

U.S. Population (spring season) 0.000046 11.5% U.S. Population (summer season) 0.000050 12.4% U.S. Population (autumn season) 0.000047 11.8% U.S. Population (winter season) 0.000050 12.4%

Northeast region 0.000053 13.3% Midwest region 0.000047 11.7% Southern region 0.000041 10.2% Western region 0.000057 14.2%

Hispanics 0.000052 12.9% Non-hispanic whites 0.000049 12.3% Non-hispanic blacks 0.000038 9.4% Non-hisp/non-white/non-black 0.000049 12.3%

All infants (< 1 year) 0.000052 13.0% Nursing infants 0.000039 9.7% Non-nursing infants 0.000057 14.2% Children 1-6 yrs 0.000189 47.3% Children 7-12 yrs 0.000059 14.7%

Females 13-19 (not preg or nursing) 0.000025 6.2% Females 20+ (not preg or nursing) 0.000034 8.6% Females 13-50 yrs 0.000034 8.5% Females 13+ (preg/not nursing) 0.000034 8.4% Females 13+ (nursing) 0.000044 11.0%

Males 13-19 yrs 0.000018 4.6% Males 20+ yrs 0.000028 7.1% Seniors 55+ 0.000040 9.9%

Children 1-2 yrs 0.000281 70.3% Children 3-5 yrs 0.000163 40.7% Children 6-12 yrs 0.000063 15.7%

Youth 13-19 yrs 0.000022 5.4% Adults 20-49 yrs 0.000028 6.9% Adults 50+ yrs 0.000039 9.7% Females 13-49 yrs 0.000030 7.4%

-------------------------------------------------------------------------------

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 37 of 62 Attachment 9: Residue Input File – ETU Acute Analysis – Food Only Filename: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM Files\Metiram\ETUAcutemetiramPRIAsept2006foodonly.R98 Chemical: ETU RfD(Chronic): .0002 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .005 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0601 Date created/last modified: 09-27-2006/14:29:18/8 Program ver. 2.03 Comment: Females 13+ only

-------------------------------------------------------------------------------- RDL indices and parameters for Monte Carlo Analysis: Index Dist Parameter #1 Param #2 Param #3 Comment # Code

----- ---- ------------ -------- -------- ------- 1 6 appleuncookedETU.rdf 2 6 applecookedETU.rdf 3 6 applejuiceuncookedETU.rdf 4 6 applejuicecookedETU.rdf 5 6 PotatoETUuncookedMBS.rdf 6 6 PotatoETUCookedMBS.rdf 7 6 ETUuncookedbananas.rdf 8 6 ETUcookedbananas.rdf 9 6 ETUuncookedgrapes.rdf 10 6 ETUcookedgrapes.rdf 11 6 ETUuncookedraisins.rdf 12 6 ETUcookedraisins.rdf 13 6 ETUuncookedwine.rdf 14 6 ETUcookedwine.rdf 15 6 ETUuncookedgrapejuice.rdf 16 6 ETUcookedgrapejuice.rdf

EPA Crop Commodity Name Def Res Adj.Factors RDL Comment Code Grp (ppm) #1 #2 Pntr

-------- ---- ------------------------------- ---------- ------ ------ --- ------- 11000070 11 Apple, fruit with peel 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 1 washin Full comment: washing factor 150-Uncooked; Cured etc; Cook Meth N/S 1.000000 1.000 1.000 1 washin Full comment: washing factor 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 2 washin Full comment: washing factor 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 2 washin Full comment: washing factor 11000080 11 Apple, peeled fruit 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 1 peelin Full comment: peeling factor 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 2 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 2 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 2 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 2 232-Cooked; Dried; Boiled 1.000000 1.000 1.000 2 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 2 11000081 11 Apple, peeled fruit-babyfood 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 2 11000090 11 Apple, dried 130-Uncooked; Dried; Cook Meth N/S 0.002600 1.000 1.000 210-Cooked; Fresh or N/S; Cook Meth N/S 0.000900 1.000 1.000 211-Cooked; Fresh or N/S; Baked 0.000900 1.000 1.000

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 38 of 62 230-Cooked; Dried; Cook Meth N/S 0.000900 1.000 1.000 11000091 11 Apple, dried-babyfood 230-Cooked; Dried; Cook Meth N/S 0.000900 1.000 1.000 11000100 11 Apple, juice 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 3 120-Uncooked; Frozen; Cook Meth N/S 1.000000 1.000 1.000 3 130-Uncooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 3 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 4 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 4 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 4 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 4 214-Cooked; Fresh or N/S; Fried/baked 1.000000 1.000 1.000 4 230-Cooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 4 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 4 juicin Full comment: juicing factor 11000101 11 Apple, juice-babyfood 230-Cooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 4 juicin Full comment: juicing factor 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 4 juicin Full comment: juicing factor 11000110 11 Apple, sauce 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 3 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 2 Cookin Full comment: Cooking factor 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 2 Cookin Full comment: Cooking factor 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 2 Cookin Full comment: Cooking factor 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 2 Cookin Full comment: Cooking factor 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 2 Cookin Full comment: Cooking factor 11000111 11 Apple, sauce-babyfood 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 2 95000230 O Banana 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 7 120-Uncooked; Frozen; Cook Meth N/S 1.000000 1.000 1.000 7 130-Uncooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 7 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 8 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 8 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 8 223-Cooked; Frozen; Fried 1.000000 1.000 1.000 8 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 8 95000231 O Banana-babyfood

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 39 of 62 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 8 230-Cooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 8 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 8 95000240 O Banana, dried 130-Uncooked; Dried; Cook Meth N/S 0.282000 1.000 1.000 211-Cooked; Fresh or N/S; Baked 0.023600 1.000 1.000 230-Cooked; Dried; Cook Meth N/S 0.023600 1.000 1.000 95000241 O Banana, dried-babyfood 230-Cooked; Dried; Cook Meth N/S 0.023600 1.000 1.000 95001750 O Grape 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 9 120-Uncooked; Frozen; Cook Meth N/S 1.000000 1.000 1.000 9 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 10 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 10 95001760 O Grape, juice 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 15 120-Uncooked; Frozen; Cook Meth N/S 1.000000 1.000 1.000 15 130-Uncooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 15 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 16 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 16 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 16 230-Cooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 16 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 16 95001761 O Grape, juice-babyfood 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 16 95001770 O Grape, leaves 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 10 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 10 95001780 O Grape, raisin 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 11 130-Uncooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 11 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 12 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 12 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 12 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 12 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 12 230-Cooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 12 232-Cooked; Dried; Boiled 1.000000 1.000 1.000 12 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 12 95001790 O Grape, wine and sherry 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 14

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 40 of 62 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 14 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 14 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 14 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 14 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 14 230-Cooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 14 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 14 242-Cooked; Canned; Boiled 1.000000 1.000 1.000 14 250-Cooked; Cured etc; Cook Meth N/S 1.000000 1.000 1.000 14 01032960 1C Potato, chips 211-Cooked; Fresh or N/S; Baked 0.000310 1.000 1.000 cookin Full comment: cooking factor 213-Cooked; Fresh or N/S; Fried 0.000310 1.000 1.000 cookin Full comment: cooking factor 01032970 1C Potato, dry (granules/ flakes) 211-Cooked; Fresh or N/S; Baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 212-Cooked; Fresh or N/S; Boiled 0.000867 1.000 1.000 cookin Full comment: cooking factor 213-Cooked; Fresh or N/S; Fried 0.000867 1.000 1.000 cookin Full comment: cooking factor 214-Cooked; Fresh or N/S; Fried/baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 221-Cooked; Frozen; Baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 230-Cooked; Dried; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 232-Cooked; Dried; Boiled 0.000867 1.000 1.000 cookin Full comment: cooking factor 01032971 1C Potato, dry (granules/ flakes)-b 240-Cooked; Canned; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 01032980 1C Potato, flour 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.000986 1.000 1.000 120-Uncooked; Frozen; Cook Meth N/S 0.000986 1.000 1.000 130-Uncooked; Dried; Cook Meth N/S 0.000986 1.000 1.000 210-Cooked; Fresh or N/S; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 211-Cooked; Fresh or N/S; Baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 212-Cooked; Fresh or N/S; Boiled 0.000867 1.000 1.000 cookin Full comment: cooking factor 213-Cooked; Fresh or N/S; Fried 0.000867 1.000 1.000 cookin Full comment: cooking factor 214-Cooked; Fresh or N/S; Fried/baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 215-Cooked; Fresh or N/S; Boiled/baked 0.000867 1.000 1.000 cookin

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 41 of 62 Full comment: cooking factor 220-Cooked; Frozen; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 221-Cooked; Frozen; Baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 222-Cooked; Frozen; Boiled 0.000867 1.000 1.000 cookin Full comment: cooking factor 223-Cooked; Frozen; Fried 0.000867 1.000 1.000 cookin Full comment: cooking factor 230-Cooked; Dried; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 231-Cooked; Dried; Baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 232-Cooked; Dried; Boiled 0.000867 1.000 1.000 cookin Full comment: cooking factor 233-Cooked; Dried; Fried 0.000867 1.000 1.000 cookin Full comment: cooking factor 240-Cooked; Canned; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 242-Cooked; Canned; Boiled 0.000867 1.000 1.000 cookin Full comment: cooking factor 250-Cooked; Cured etc; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 251-Cooked; Cured etc; Baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 252-Cooked; Cured etc; Boiled 0.000867 1.000 1.000 cookin Full comment: cooking factor 253-Cooked; Cured etc; Fried 0.000867 1.000 1.000 cookin Full comment: cooking factor 01032981 1C Potato, flour-babyfood 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.000986 1.000 1.000 130-Uncooked; Dried; Cook Meth N/S 0.000986 1.000 1.000 240-Cooked; Canned; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 01032990 1C Potato, tuber, w/peel 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 01032991 1C Potato, tuber, w/peel-babyfood 1.000000 1.000 1.000 6 01033000 1C Potato, tuber, w/o peel 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 5 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 6 cookin

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 42 of 62 Full comment: cooking factor 223-Cooked; Frozen; Fried 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 232-Cooked; Dried; Boiled 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 233-Cooked; Dried; Fried 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 242-Cooked; Canned; Boiled 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 252-Cooked; Cured etc; Boiled 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 253-Cooked; Cured etc; Fried 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 01033001 1C Potato, tuber, w/o peel-babyfood 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 6 cookin Full comment: cooking factor

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 43 of 62 Attachment 10: Residue Input File – ETU Acute Analysis – Food and Water Filename: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM Files\Metiram\ETUAcutemetiramPRIAsept2006foodand water.R98 Chemical: ETU RfD(Chronic): .0002 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .005 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0601 Date created/last modified: 09-27-2006/14:32:56/8 Program ver. 2.03 Comment: Females 13+ only food plus water

-------------------------------------------------------------------------------- RDL indices and parameters for Monte Carlo Analysis: Index Dist Parameter #1 Param #2 Param #3 Comment # Code

----- ---- ------------ -------- -------- ------- 1 6 appleuncookedETU.rdf 2 6 applecookedETU.rdf 3 6 applejuiceuncookedETU.rdf 4 6 applejuicecookedETU.rdf 5 6 PotatoETUuncookedMBS.rdf 6 6 PotatoETUCookedMBS.rdf 7 6 ETUuncookedbananas.rdf 8 6 ETUcookedbananas.rdf 9 6 ETUuncookedgrapes.rdf 10 6 ETUcookedgrapes.rdf 11 6 ETUuncookedraisins.rdf 12 6 ETUcookedraisins.rdf 13 6 ETUuncookedwine.rdf 14 6 ETUcookedwine.rdf 15 6 ETUuncookedgrapejuice.rdf 16 6 ETUcookedgrapejuice.rdf

EPA Crop Commodity Name Def Res Adj.Factors RDL Comment Code Grp (ppm) #1 #2 Pntr

-------- ---- ------------------------------- ---------- ------ ------ --- ------- 11000070 11 Apple, fruit with peel 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 1 washin Full comment: washing factor 150-Uncooked; Cured etc; Cook Meth N/S 1.000000 1.000 1.000 1 washin Full comment: washing factor 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 2 washin Full comment: washing factor 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 2 washin Full comment: washing factor 11000080 11 Apple, peeled fruit 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 1 peelin Full comment: peeling factor 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 2 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 2 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 2 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 2 232-Cooked; Dried; Boiled 1.000000 1.000 1.000 2 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 2 11000081 11 Apple, peeled fruit-babyfood 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 2 11000090 11 Apple, dried 130-Uncooked; Dried; Cook Meth N/S 0.002600 1.000 1.000 210-Cooked; Fresh or N/S; Cook Meth N/S 0.000900 1.000 1.000 211-Cooked; Fresh or N/S; Baked 0.000900 1.000 1.000

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 44 of 62 230-Cooked; Dried; Cook Meth N/S 0.000900 1.000 1.000 11000091 11 Apple, dried-babyfood 230-Cooked; Dried; Cook Meth N/S 0.000900 1.000 1.000 11000100 11 Apple, juice 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 3 120-Uncooked; Frozen; Cook Meth N/S 1.000000 1.000 1.000 3 130-Uncooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 3 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 4 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 4 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 4 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 4 214-Cooked; Fresh or N/S; Fried/baked 1.000000 1.000 1.000 4 230-Cooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 4 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 4 juicin Full comment: juicing factor 11000101 11 Apple, juice-babyfood 230-Cooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 4 juicin Full comment: juicing factor 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 4 juicin Full comment: juicing factor 11000110 11 Apple, sauce 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 3 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 2 Cookin Full comment: Cooking factor 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 2 Cookin Full comment: Cooking factor 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 2 Cookin Full comment: Cooking factor 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 2 Cookin Full comment: Cooking factor 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 2 Cookin Full comment: Cooking factor 11000111 11 Apple, sauce-babyfood 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 2 95000230 O Banana 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 7 120-Uncooked; Frozen; Cook Meth N/S 1.000000 1.000 1.000 7 130-Uncooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 7 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 8 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 8 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 8 223-Cooked; Frozen; Fried 1.000000 1.000 1.000 8 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 8 95000231 O Banana-babyfood

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 45 of 62 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 8 230-Cooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 8 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 8 95000240 O Banana, dried 130-Uncooked; Dried; Cook Meth N/S 0.282000 1.000 1.000 211-Cooked; Fresh or N/S; Baked 0.023600 1.000 1.000 230-Cooked; Dried; Cook Meth N/S 0.023600 1.000 1.000 95000241 O Banana, dried-babyfood 230-Cooked; Dried; Cook Meth N/S 0.023600 1.000 1.000 95001750 O Grape 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 9 120-Uncooked; Frozen; Cook Meth N/S 1.000000 1.000 1.000 9 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 10 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 10 95001760 O Grape, juice 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 15 120-Uncooked; Frozen; Cook Meth N/S 1.000000 1.000 1.000 15 130-Uncooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 15 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 16 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 16 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 16 230-Cooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 16 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 16 95001761 O Grape, juice-babyfood 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 16 95001770 O Grape, leaves 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 10 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 10 95001780 O Grape, raisin 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 11 130-Uncooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 11 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 12 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 12 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 12 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 12 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 12 230-Cooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 12 232-Cooked; Dried; Boiled 1.000000 1.000 1.000 12 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 12 95001790 O Grape, wine and sherry 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 14

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 46 of 62 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 14 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 14 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 14 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 14 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 14 230-Cooked; Dried; Cook Meth N/S 1.000000 1.000 1.000 14 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 14 242-Cooked; Canned; Boiled 1.000000 1.000 1.000 14 250-Cooked; Cured etc; Cook Meth N/S 1.000000 1.000 1.000 14 01032960 1C Potato, chips 211-Cooked; Fresh or N/S; Baked 0.000310 1.000 1.000 cookin Full comment: cooking factor 213-Cooked; Fresh or N/S; Fried 0.000310 1.000 1.000 cookin Full comment: cooking factor 01032970 1C Potato, dry (granules/ flakes) 211-Cooked; Fresh or N/S; Baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 212-Cooked; Fresh or N/S; Boiled 0.000867 1.000 1.000 cookin Full comment: cooking factor 213-Cooked; Fresh or N/S; Fried 0.000867 1.000 1.000 cookin Full comment: cooking factor 214-Cooked; Fresh or N/S; Fried/baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 221-Cooked; Frozen; Baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 230-Cooked; Dried; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 232-Cooked; Dried; Boiled 0.000867 1.000 1.000 cookin Full comment: cooking factor 01032971 1C Potato, dry (granules/ flakes)-b 240-Cooked; Canned; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 01032980 1C Potato, flour 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.000986 1.000 1.000 120-Uncooked; Frozen; Cook Meth N/S 0.000986 1.000 1.000 130-Uncooked; Dried; Cook Meth N/S 0.000986 1.000 1.000 210-Cooked; Fresh or N/S; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 211-Cooked; Fresh or N/S; Baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 212-Cooked; Fresh or N/S; Boiled 0.000867 1.000 1.000 cookin Full comment: cooking factor 213-Cooked; Fresh or N/S; Fried 0.000867 1.000 1.000 cookin Full comment: cooking factor 214-Cooked; Fresh or N/S; Fried/baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 215-Cooked; Fresh or N/S; Boiled/baked 0.000867 1.000 1.000 cookin

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 47 of 62 Full comment: cooking factor 220-Cooked; Frozen; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 221-Cooked; Frozen; Baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 222-Cooked; Frozen; Boiled 0.000867 1.000 1.000 cookin Full comment: cooking factor 223-Cooked; Frozen; Fried 0.000867 1.000 1.000 cookin Full comment: cooking factor 230-Cooked; Dried; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 231-Cooked; Dried; Baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 232-Cooked; Dried; Boiled 0.000867 1.000 1.000 cookin Full comment: cooking factor 233-Cooked; Dried; Fried 0.000867 1.000 1.000 cookin Full comment: cooking factor 240-Cooked; Canned; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 242-Cooked; Canned; Boiled 0.000867 1.000 1.000 cookin Full comment: cooking factor 250-Cooked; Cured etc; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 251-Cooked; Cured etc; Baked 0.000867 1.000 1.000 cookin Full comment: cooking factor 252-Cooked; Cured etc; Boiled 0.000867 1.000 1.000 cookin Full comment: cooking factor 253-Cooked; Cured etc; Fried 0.000867 1.000 1.000 cookin Full comment: cooking factor 01032981 1C Potato, flour-babyfood 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.000986 1.000 1.000 130-Uncooked; Dried; Cook Meth N/S 0.000986 1.000 1.000 240-Cooked; Canned; Cook Meth N/S 0.000867 1.000 1.000 cookin Full comment: cooking factor 01032990 1C Potato, tuber, w/peel 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 01032991 1C Potato, tuber, w/peel-babyfood 1.000000 1.000 1.000 6 01033000 1C Potato, tuber, w/o peel 110-Uncooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 5 210-Cooked; Fresh or N/S; Cook Meth N/S 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 211-Cooked; Fresh or N/S; Baked 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 212-Cooked; Fresh or N/S; Boiled 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 213-Cooked; Fresh or N/S; Fried 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 221-Cooked; Frozen; Baked 1.000000 1.000 1.000 6 cookin

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 48 of 62 Full comment: cooking factor 223-Cooked; Frozen; Fried 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 232-Cooked; Dried; Boiled 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 233-Cooked; Dried; Fried 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 242-Cooked; Canned; Boiled 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 252-Cooked; Cured etc; Boiled 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 253-Cooked; Cured etc; Fried 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 01033001 1C Potato, tuber, w/o peel-babyfood 240-Cooked; Canned; Cook Meth N/S 1.000000 1.000 1.000 6 cookin Full comment: cooking factor 86010000 O Water, direct, all sources 0.025200 1.000 1.000 86020000 O Water, indirect, all sources 0.025200 1.000 1.000

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 49 of 62 Attachment 11: Residue Input File – ETU Chronic and Cancer Analyses – Food Only Filename: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM Files\Metiram\ETUChronicmetiramPRIASept2006foodonly.R98 Chemical: Metiram - ETU RfD(Chronic): .0002 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .005 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0601 Date created/last modified: 09-27-2006/14:45:48/8 Program ver. 2.03 Comment: food only

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 11000070 11 Apple, fruit with peel 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.010000 1.000 0.150 150-Uncooked; Cured etc; Cook Meth N/S 0.010000 1.000 0.150 211-Cooked; Fresh or N/S; Baked 0.003700 1.000 0.150 213-Cooked; Fresh or N/S; Fried 0.003700 1.000 0.150 11000080 11 Apple, peeled fruit 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.010000 1.000 0.150 210-Cooked; Fresh or N/S; Cook Meth N/S 0.003700 1.000 0.150 211-Cooked; Fresh or N/S; Baked 0.003700 1.000 0.150 213-Cooked; Fresh or N/S; Fried 0.003700 1.000 0.150 221-Cooked; Frozen; Baked 0.003700 1.000 0.150 232-Cooked; Dried; Boiled 0.003700 1.000 0.150 240-Cooked; Canned; Cook Meth N/S 0.003700 1.000 0.150 11000081 11 Apple, peeled fruit-babyfood 0.003700 1.000 0.150 11000090 11 Apple, dried 130-Uncooked; Dried; Cook Meth N/S 0.010000 1.000 0.150 210-Cooked; Fresh or N/S; Cook Meth N/S 0.003700 1.000 0.150 211-Cooked; Fresh or N/S; Baked 0.003700 1.000 0.150 230-Cooked; Dried; Cook Meth N/S 0.003700 1.000 0.150 11000091 11 Apple, dried-babyfood 230-Cooked; Dried; Cook Meth N/S 0.003700 1.000 0.150 11000100 11 Apple, juice 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.004900 1.000 0.150 120-Uncooked; Frozen; Cook Meth N/S 0.004900 1.000 0.150 130-Uncooked; Dried; Cook Meth N/S 0.004900 1.000 0.150 210-Cooked; Fresh or N/S; Cook Meth N/S 0.003800 1.000 0.150 211-Cooked; Fresh or N/S; Baked 0.003800 1.000 0.150 212-Cooked; Fresh or N/S; Boiled 0.003800 1.000 0.150 213-Cooked; Fresh or N/S; Fried 0.003800 1.000 0.150 214-Cooked; Fresh or N/S; Fried/baked 0.003800 1.000 0.150 230-Cooked; Dried; Cook Meth N/S 0.003800 1.000 0.150 240-Cooked; Canned; Cook Meth N/S 0.003800 1.000 0.150 11000101 11 Apple, juice-babyfood 230-Cooked; Dried; Cook Meth N/S

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 50 of 62 0.003800 1.000 0.150 240-Cooked; Canned; Cook Meth N/S 0.003800 1.000 0.150 11000110 11 Apple, sauce 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.010000 1.000 0.150 210-Cooked; Fresh or N/S; Cook Meth N/S 0.003700 1.000 0.150 211-Cooked; Fresh or N/S; Baked 0.003700 1.000 0.150 212-Cooked; Fresh or N/S; Boiled 0.003700 1.000 0.150 221-Cooked; Frozen; Baked 0.003700 1.000 0.150 240-Cooked; Canned; Cook Meth N/S 0.003700 1.000 0.150 11000111 11 Apple, sauce-babyfood 240-Cooked; Canned; Cook Meth N/S 0.003700 1.000 0.150 95000230 O Banana 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.031300 1.000 1.000 120-Uncooked; Frozen; Cook Meth N/S 0.031300 1.000 1.000 130-Uncooked; Dried; Cook Meth N/S 0.031300 1.000 1.000 211-Cooked; Fresh or N/S; Baked 0.023600 1.000 1.000 212-Cooked; Fresh or N/S; Boiled 0.023600 1.000 1.000 213-Cooked; Fresh or N/S; Fried 0.023600 1.000 1.000 223-Cooked; Frozen; Fried 0.023600 1.000 1.000 240-Cooked; Canned; Cook Meth N/S 0.023600 1.000 1.000 95000231 O Banana-babyfood 211-Cooked; Fresh or N/S; Baked 0.031300 1.000 1.000 230-Cooked; Dried; Cook Meth N/S 0.031300 1.000 1.000 240-Cooked; Canned; Cook Meth N/S 0.031300 1.000 1.000 95000240 O Banana, dried 130-Uncooked; Dried; Cook Meth N/S 0.028200 1.000 1.000 211-Cooked; Fresh or N/S; Baked 0.023600 1.000 1.000 230-Cooked; Dried; Cook Meth N/S 0.023600 1.000 1.000 95000241 O Banana, dried-babyfood 0.023600 1.000 1.000 95001750 O Grape 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.035200 1.000 0.440 120-Uncooked; Frozen; Cook Meth N/S 0.035200 1.000 0.440 210-Cooked; Fresh or N/S; Cook Meth N/S 0.026200 1.000 0.440 240-Cooked; Canned; Cook Meth N/S 0.026200 1.000 0.440 95001760 O Grape, juice 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.032700 1.000 0.440 120-Uncooked; Frozen; Cook Meth N/S 0.032700 1.000 0.440 130-Uncooked; Dried; Cook Meth N/S 0.032700 1.000 0.440 210-Cooked; Fresh or N/S; Cook Meth N/S 0.018900 1.000 0.440 211-Cooked; Fresh or N/S; Baked 0.018900 1.000 0.440 221-Cooked; Frozen; Baked 0.018900 1.000 0.440 230-Cooked; Dried; Cook Meth N/S

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 51 of 62 0.018900 1.000 0.440 240-Cooked; Canned; Cook Meth N/S 0.018900 1.000 0.440 95001761 O Grape, juice-babyfood 240-Cooked; Canned; Cook Meth N/S 0.018900 1.000 0.440 95001770 O Grape, leaves 210-Cooked; Fresh or N/S; Cook Meth N/S 0.026200 1.000 0.440 211-Cooked; Fresh or N/S; Baked 0.026200 1.000 0.440 95001780 O Grape, raisin 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.069000 1.000 0.440 130-Uncooked; Dried; Cook Meth N/S 0.069000 1.000 0.440 210-Cooked; Fresh or N/S; Cook Meth N/S 0.021100 1.000 0.440 211-Cooked; Fresh or N/S; Baked 0.021100 1.000 0.440 212-Cooked; Fresh or N/S; Boiled 0.021100 1.000 0.440 213-Cooked; Fresh or N/S; Fried 0.021100 1.000 0.440 221-Cooked; Frozen; Baked 0.021100 1.000 0.440 230-Cooked; Dried; Cook Meth N/S 0.021100 1.000 0.440 232-Cooked; Dried; Boiled 0.021100 1.000 0.440 240-Cooked; Canned; Cook Meth N/S 0.021100 1.000 0.440 95001790 O Grape, wine and sherry 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.032700 1.000 0.200 210-Cooked; Fresh or N/S; Cook Meth N/S 0.018900 1.000 0.200 211-Cooked; Fresh or N/S; Baked 0.018900 1.000 0.200 212-Cooked; Fresh or N/S; Boiled 0.018900 1.000 0.200 213-Cooked; Fresh or N/S; Fried 0.018900 1.000 0.200 221-Cooked; Frozen; Baked 0.018900 1.000 0.200 230-Cooked; Dried; Cook Meth N/S 0.018900 1.000 0.200 240-Cooked; Canned; Cook Meth N/S 0.018900 1.000 0.200 242-Cooked; Canned; Boiled 0.018900 1.000 0.200 250-Cooked; Cured etc; Cook Meth N/S 0.018900 1.000 0.200 01032960 1C Potato, chips 211-Cooked; Fresh or N/S; Baked 0.000300 1.000 0.100 213-Cooked; Fresh or N/S; Fried 0.000300 1.000 0.100 01032970 1C Potato, dry (granules/ flakes) 0.008700 1.000 0.100 01032971 1C Potato, dry (granules/ flakes)-b 0.008700 1.000 0.100 01032980 1C Potato, flour 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.009900 1.000 0.100 120-Uncooked; Frozen; Cook Meth N/S 0.009900 1.000 0.100 130-Uncooked; Dried; Cook Meth N/S 0.009900 1.000 0.100 210-Cooked; Fresh or N/S; Cook Meth N/S 0.008700 1.000 0.100 211-Cooked; Fresh or N/S; Baked 0.008700 1.000 0.100 212-Cooked; Fresh or N/S; Boiled 0.008700 1.000 0.100 213-Cooked; Fresh or N/S; Fried 0.008700 1.000 0.100

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 52 of 62 214-Cooked; Fresh or N/S; Fried/baked 0.008700 1.000 0.100 215-Cooked; Fresh or N/S; Boiled/baked 0.008700 1.000 0.100 220-Cooked; Frozen; Cook Meth N/S 0.008700 1.000 0.100 221-Cooked; Frozen; Baked 0.008700 1.000 0.100 222-Cooked; Frozen; Boiled 0.008700 1.000 0.100 223-Cooked; Frozen; Fried 0.008700 1.000 0.100 230-Cooked; Dried; Cook Meth N/S 0.008700 1.000 0.100 231-Cooked; Dried; Baked 0.008700 1.000 0.100 232-Cooked; Dried; Boiled 0.008700 1.000 0.100 233-Cooked; Dried; Fried 0.008700 1.000 0.100 240-Cooked; Canned; Cook Meth N/S 0.008700 1.000 0.100 242-Cooked; Canned; Boiled 0.008700 1.000 0.100 250-Cooked; Cured etc; Cook Meth N/S 0.008700 1.000 0.100 251-Cooked; Cured etc; Baked 0.008700 1.000 0.100 252-Cooked; Cured etc; Boiled 0.008700 1.000 0.100 253-Cooked; Cured etc; Fried 0.008700 1.000 0.100 01032981 1C Potato, flour-babyfood 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.009900 1.000 0.100 130-Uncooked; Dried; Cook Meth N/S 0.009900 1.000 0.100 240-Cooked; Canned; Cook Meth N/S 0.008700 1.000 0.100 01032990 1C Potato, tuber, w/peel 210-Cooked; Fresh or N/S; Cook Meth N/S 0.003300 1.000 0.100 211-Cooked; Fresh or N/S; Baked 0.003300 1.000 0.100 212-Cooked; Fresh or N/S; Boiled 0.003300 1.000 0.100 213-Cooked; Fresh or N/S; Fried 0.003300 1.000 0.100 01032991 1C Potato, tuber, w/peel-babyfood 0.003300 1.000 0.100 01033000 1C Potato, tuber, w/o peel 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.002700 1.000 0.100 210-Cooked; Fresh or N/S; Cook Meth N/S 0.002700 1.000 0.100 211-Cooked; Fresh or N/S; Baked 0.002700 1.000 0.100 212-Cooked; Fresh or N/S; Boiled 0.002700 1.000 0.100 213-Cooked; Fresh or N/S; Fried 0.002700 1.000 0.100 221-Cooked; Frozen; Baked 0.002700 1.000 0.100 223-Cooked; Frozen; Fried 0.002700 1.000 0.100 232-Cooked; Dried; Boiled 0.002700 1.000 0.100 233-Cooked; Dried; Fried 0.002700 1.000 0.100 240-Cooked; Canned; Cook Meth N/S 0.002700 1.000 0.100 242-Cooked; Canned; Boiled 0.002700 1.000 0.100 252-Cooked; Cured etc; Boiled 0.002700 1.000 0.100 253-Cooked; Cured etc; Fried 0.002700 1.000 0.100 01033001 1C Potato, tuber, w/o peel-babyfood 240-Cooked; Canned; Cook Meth N/S 0.002700 1.000 0.100

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 53 of 62 Attachment 12: Residue Input File – ETU Chronic and Cancer Analyses – Food and Water Filename: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM Files\Metiram\ETUChronicmetiramPRIASept2006foodpluswater.R98 Chemical: Metiram - ETU RfD(Chronic): .0002 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .005 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Q*= .0601 Date created/last modified: 09-27-2006/14:46:41/8 Program ver. 2.03 Comment: food plus water

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 11000070 11 Apple, fruit with peel 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.010000 1.000 0.150 150-Uncooked; Cured etc; Cook Meth N/S 0.010000 1.000 0.150 211-Cooked; Fresh or N/S; Baked 0.003700 1.000 0.150 213-Cooked; Fresh or N/S; Fried 0.003700 1.000 0.150 11000080 11 Apple, peeled fruit 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.010000 1.000 0.150 210-Cooked; Fresh or N/S; Cook Meth N/S 0.003700 1.000 0.150 211-Cooked; Fresh or N/S; Baked 0.003700 1.000 0.150 213-Cooked; Fresh or N/S; Fried 0.003700 1.000 0.150 221-Cooked; Frozen; Baked 0.003700 1.000 0.150 232-Cooked; Dried; Boiled 0.003700 1.000 0.150 240-Cooked; Canned; Cook Meth N/S 0.003700 1.000 0.150 11000081 11 Apple, peeled fruit-babyfood 0.003700 1.000 0.150 11000090 11 Apple, dried 130-Uncooked; Dried; Cook Meth N/S 0.010000 1.000 0.150 210-Cooked; Fresh or N/S; Cook Meth N/S 0.003700 1.000 0.150 211-Cooked; Fresh or N/S; Baked 0.003700 1.000 0.150 230-Cooked; Dried; Cook Meth N/S 0.003700 1.000 0.150 11000091 11 Apple, dried-babyfood 230-Cooked; Dried; Cook Meth N/S 0.003700 1.000 0.150 11000100 11 Apple, juice 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.004900 1.000 0.150 120-Uncooked; Frozen; Cook Meth N/S 0.004900 1.000 0.150 130-Uncooked; Dried; Cook Meth N/S 0.004900 1.000 0.150 210-Cooked; Fresh or N/S; Cook Meth N/S 0.003800 1.000 0.150 211-Cooked; Fresh or N/S; Baked 0.003800 1.000 0.150 212-Cooked; Fresh or N/S; Boiled 0.003800 1.000 0.150 213-Cooked; Fresh or N/S; Fried 0.003800 1.000 0.150 214-Cooked; Fresh or N/S; Fried/baked 0.003800 1.000 0.150 230-Cooked; Dried; Cook Meth N/S 0.003800 1.000 0.150 240-Cooked; Canned; Cook Meth N/S 0.003800 1.000 0.150 11000101 11 Apple, juice-babyfood

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 54 of 62 230-Cooked; Dried; Cook Meth N/S 0.003800 1.000 0.150 240-Cooked; Canned; Cook Meth N/S 0.003800 1.000 0.150 11000110 11 Apple, sauce 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.010000 1.000 0.150 210-Cooked; Fresh or N/S; Cook Meth N/S 0.003700 1.000 0.150 211-Cooked; Fresh or N/S; Baked 0.003700 1.000 0.150 212-Cooked; Fresh or N/S; Boiled 0.003700 1.000 0.150 221-Cooked; Frozen; Baked 0.003700 1.000 0.150 240-Cooked; Canned; Cook Meth N/S 0.003700 1.000 0.150 11000111 11 Apple, sauce-babyfood 240-Cooked; Canned; Cook Meth N/S 0.003700 1.000 0.150 95000230 O Banana 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.031300 1.000 1.000 120-Uncooked; Frozen; Cook Meth N/S 0.031300 1.000 1.000 130-Uncooked; Dried; Cook Meth N/S 0.031300 1.000 1.000 211-Cooked; Fresh or N/S; Baked 0.023600 1.000 1.000 212-Cooked; Fresh or N/S; Boiled 0.023600 1.000 1.000 213-Cooked; Fresh or N/S; Fried 0.023600 1.000 1.000 223-Cooked; Frozen; Fried 0.023600 1.000 1.000 240-Cooked; Canned; Cook Meth N/S 0.023600 1.000 1.000 95000231 O Banana-babyfood 211-Cooked; Fresh or N/S; Baked 0.031300 1.000 1.000 230-Cooked; Dried; Cook Meth N/S 0.031300 1.000 1.000 240-Cooked; Canned; Cook Meth N/S 0.031300 1.000 1.000 95000240 O Banana, dried 130-Uncooked; Dried; Cook Meth N/S 0.028200 1.000 1.000 211-Cooked; Fresh or N/S; Baked 0.023600 1.000 1.000 230-Cooked; Dried; Cook Meth N/S 0.023600 1.000 1.000 95000241 O Banana, dried-babyfood 0.023600 1.000 1.000 95001750 O Grape 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.035200 1.000 0.440 120-Uncooked; Frozen; Cook Meth N/S 0.035200 1.000 0.440 210-Cooked; Fresh or N/S; Cook Meth N/S 0.026200 1.000 0.440 240-Cooked; Canned; Cook Meth N/S 0.026200 1.000 0.440 95001760 O Grape, juice 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.032700 1.000 0.440 120-Uncooked; Frozen; Cook Meth N/S 0.032700 1.000 0.440 130-Uncooked; Dried; Cook Meth N/S 0.032700 1.000 0.440 210-Cooked; Fresh or N/S; Cook Meth N/S 0.018900 1.000 0.440 211-Cooked; Fresh or N/S; Baked 0.018900 1.000 0.440 221-Cooked; Frozen; Baked 0.018900 1.000 0.440

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 55 of 62 230-Cooked; Dried; Cook Meth N/S 0.018900 1.000 0.440 240-Cooked; Canned; Cook Meth N/S 0.018900 1.000 0.440 95001761 O Grape, juice-babyfood 240-Cooked; Canned; Cook Meth N/S 0.018900 1.000 0.440 95001770 O Grape, leaves 210-Cooked; Fresh or N/S; Cook Meth N/S 0.026200 1.000 0.440 211-Cooked; Fresh or N/S; Baked 0.026200 1.000 0.440 95001780 O Grape, raisin 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.069000 1.000 0.440 130-Uncooked; Dried; Cook Meth N/S 0.069000 1.000 0.440 210-Cooked; Fresh or N/S; Cook Meth N/S 0.021100 1.000 0.440 211-Cooked; Fresh or N/S; Baked 0.021100 1.000 0.440 212-Cooked; Fresh or N/S; Boiled 0.021100 1.000 0.440 213-Cooked; Fresh or N/S; Fried 0.021100 1.000 0.440 221-Cooked; Frozen; Baked 0.021100 1.000 0.440 230-Cooked; Dried; Cook Meth N/S 0.021100 1.000 0.440 232-Cooked; Dried; Boiled 0.021100 1.000 0.440 240-Cooked; Canned; Cook Meth N/S 0.021100 1.000 0.440 95001790 O Grape, wine and sherry 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.032700 1.000 0.200 210-Cooked; Fresh or N/S; Cook Meth N/S 0.018900 1.000 0.200 211-Cooked; Fresh or N/S; Baked 0.018900 1.000 0.200 212-Cooked; Fresh or N/S; Boiled 0.018900 1.000 0.200 213-Cooked; Fresh or N/S; Fried 0.018900 1.000 0.200 221-Cooked; Frozen; Baked 0.018900 1.000 0.200 230-Cooked; Dried; Cook Meth N/S 0.018900 1.000 0.200 240-Cooked; Canned; Cook Meth N/S 0.018900 1.000 0.200 242-Cooked; Canned; Boiled 0.018900 1.000 0.200 250-Cooked; Cured etc; Cook Meth N/S 0.018900 1.000 0.200 01032960 1C Potato, chips 211-Cooked; Fresh or N/S; Baked 0.000300 1.000 0.100 213-Cooked; Fresh or N/S; Fried 0.000300 1.000 0.100 01032970 1C Potato, dry (granules/ flakes) 0.008700 1.000 0.100 01032971 1C Potato, dry (granules/ flakes)-b 0.008700 1.000 0.100 01032980 1C Potato, flour 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.009900 1.000 0.100 120-Uncooked; Frozen; Cook Meth N/S 0.009900 1.000 0.100 130-Uncooked; Dried; Cook Meth N/S 0.009900 1.000 0.100 210-Cooked; Fresh or N/S; Cook Meth N/S 0.008700 1.000 0.100 211-Cooked; Fresh or N/S; Baked 0.008700 1.000 0.100 212-Cooked; Fresh or N/S; Boiled 0.008700 1.000 0.100 213-Cooked; Fresh or N/S; Fried

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 56 of 62 0.008700 1.000 0.100 214-Cooked; Fresh or N/S; Fried/baked 0.008700 1.000 0.100 215-Cooked; Fresh or N/S; Boiled/baked 0.008700 1.000 0.100 220-Cooked; Frozen; Cook Meth N/S 0.008700 1.000 0.100 221-Cooked; Frozen; Baked 0.008700 1.000 0.100 222-Cooked; Frozen; Boiled 0.008700 1.000 0.100 223-Cooked; Frozen; Fried 0.008700 1.000 0.100 230-Cooked; Dried; Cook Meth N/S 0.008700 1.000 0.100 231-Cooked; Dried; Baked 0.008700 1.000 0.100 232-Cooked; Dried; Boiled 0.008700 1.000 0.100 233-Cooked; Dried; Fried 0.008700 1.000 0.100 240-Cooked; Canned; Cook Meth N/S 0.008700 1.000 0.100 242-Cooked; Canned; Boiled 0.008700 1.000 0.100 250-Cooked; Cured etc; Cook Meth N/S 0.008700 1.000 0.100 251-Cooked; Cured etc; Baked 0.008700 1.000 0.100 252-Cooked; Cured etc; Boiled 0.008700 1.000 0.100 253-Cooked; Cured etc; Fried 0.008700 1.000 0.100 01032981 1C Potato, flour-babyfood 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.009900 1.000 0.100 130-Uncooked; Dried; Cook Meth N/S 0.009900 1.000 0.100 240-Cooked; Canned; Cook Meth N/S 0.008700 1.000 0.100 01032990 1C Potato, tuber, w/peel 210-Cooked; Fresh or N/S; Cook Meth N/S 0.003300 1.000 0.100 211-Cooked; Fresh or N/S; Baked 0.003300 1.000 0.100 212-Cooked; Fresh or N/S; Boiled 0.003300 1.000 0.100 213-Cooked; Fresh or N/S; Fried 0.003300 1.000 0.100 01032991 1C Potato, tuber, w/peel-babyfood 0.003300 1.000 0.100 01033000 1C Potato, tuber, w/o peel 110-Uncooked; Fresh or N/S; Cook Meth N/S 0.002700 1.000 0.100 210-Cooked; Fresh or N/S; Cook Meth N/S 0.002700 1.000 0.100 211-Cooked; Fresh or N/S; Baked 0.002700 1.000 0.100 212-Cooked; Fresh or N/S; Boiled 0.002700 1.000 0.100 213-Cooked; Fresh or N/S; Fried 0.002700 1.000 0.100 221-Cooked; Frozen; Baked 0.002700 1.000 0.100 223-Cooked; Frozen; Fried 0.002700 1.000 0.100 232-Cooked; Dried; Boiled 0.002700 1.000 0.100 233-Cooked; Dried; Fried 0.002700 1.000 0.100 240-Cooked; Canned; Cook Meth N/S 0.002700 1.000 0.100 242-Cooked; Canned; Boiled 0.002700 1.000 0.100 252-Cooked; Cured etc; Boiled 0.002700 1.000 0.100 253-Cooked; Cured etc; Fried 0.002700 1.000 0.100 01033001 1C Potato, tuber, w/o peel-babyfood 240-Cooked; Canned; Cook Meth N/S 0.002700 1.000 0.100 86010000 O Water, direct, all sources 0.000210 1.000 1.000 86020000 O Water, indirect, all sources 0.000210 1.000 1.000

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 57 of 62 Attachment 13: Results File – ETU Acute Analysis – Food Only U.S. Environmental Protection Agency Ver. 2.02 DEEM-FCID ACUTE Analysis for ETU (1994-98 data) Residue file: ETUAcutemetiramPRIAsept2006foodonly.R98 Adjustment factor #2 NOT used. Analysis Date: 09-27-2006/14:48:14 Residue file dated: 09-27-2006/14:29:18/8 Daily totals for food and foodform consumption used. MC iterations = 1000 MC list in residue file MC seed = 10 Run Comment: "Females 13+ only"

===============================================================================

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Females 13-49 yrs: 0.000066 1.33 0.000138 2.77 0.000299 5.98

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 58 of 62 Attachment 14: Results File – ETU Acute Analysis – Food and Water U.S. Environmental Protection Agency Ver. 2.02 DEEM-FCID ACUTE Analysis for ETU (1994-98 data) Residue file: ETUAcutemetiramPRIAsept2006foodand water.R98 Adjustment factor #2 NOT used. Analysis Date: 09-27-2006/15:01:14 Residue file dated: 09-27-2006/14:32:56/8 Daily totals for food and foodform consumption used. MC iterations = 1000 MC list in residue file MC seed = 10 Run Comment: "Females 13+ only food plus water"

===============================================================================

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Females 13-49 yrs: 0.001242 24.83 0.001989 39.79 0.003511 70.21

### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 59 of 62 Attachment 15: Results File – ETU Chronic Analysis – Food Only U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for METIRAM - ETU (1994-98 data) Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM Files\Metiram\ETUChronicmetiramPRIASept2006foodonly.R98 Adjustment factor #2 used. Analysis Date 09-27-2006/15:02:22 Residue file dated: 09-27-2006/14:45:48/8 Reference dose (RfD, Chronic) = .0002 mg/kg bw/day COMMENT 1: food only

=============================================================================== Total exposure by population subgroup

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Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.000018 9.0%

U.S. Population (spring season) 0.000018 8.8% U.S. Population (summer season) 0.000018 8.9% U.S. Population (autumn season) 0.000018 8.9% U.S. Population (winter season) 0.000019 9.5%

Northeast region 0.000019 9.7% Midwest region 0.000018 9.0% Southern region 0.000015 7.7% Western region 0.000021 10.5%

Hispanics 0.000021 10.6% Non-hispanic whites 0.000018 9.0% Non-hispanic blacks 0.000015 7.3% Non-hisp/non-white/non-black 0.000020 9.8%

All infants (< 1 year) 0.000051 25.4% Nursing infants 0.000035 17.5% Non-nursing infants 0.000057 28.4% Children 1-6 yrs 0.000067 33.4% Children 7-12 yrs 0.000021 10.3%

Females 13-19 (not preg or nursing) 0.000008 3.9% Females 20+ (not preg or nursing) 0.000013 6.4% Females 13-50 yrs 0.000013 6.3% Females 13+ (preg/not nursing) 0.000013 6.4% Females 13+ (nursing) 0.000016 8.2%

Males 13-19 yrs 0.000007 3.7% Males 20+ yrs 0.000011 5.5% Seniors 55+ 0.000016 7.8%

Children 1-2 yrs 0.000100 50.2% Children 3-5 yrs 0.000056 28.2% Children 6-12 yrs 0.000022 11.1% Youth 13-19 yrs 0.000008 3.8% Adults 20-49 yrs 0.000010 5.1% Adults 50+ yrs 0.000015 7.6% Females 13-49 yrs 0.000011 5.3%

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### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 60 of 62 Attachment 16: Results File – ETU Chronic Analysis – Food and Wate r U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for METIRAM - ETU (1994-98 data) Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM Files\Metiram\ETUChronicmetiramPRIASept2006foodpluswater.R98 Adjustment factor #2 used. Analysis Date 09-27-2006/15:05:18 Residue file dated: 09-27-2006/14:46:41/8 Reference dose (RfD, Chronic) = .0002 mg/kg bw/day COMMENT 1: food plus water

=============================================================================== Total exposure by population subgroup

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Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.000022 11.2%

U.S. Population (spring season) 0.000022 11.0% U.S. Population (summer season) 0.000023 11.3% U.S. Population (autumn season) 0.000022 11.1% U.S. Population (winter season) 0.000023 11.6%

Northeast region 0.000023 11.7% Midwest region 0.000022 11.2% Southern region 0.000020 9.8% Western region 0.000026 13.1%

Hispanics 0.000026 13.1% Non-hispanic whites 0.000022 11.2% Non-hispanic blacks 0.000019 9.4% Non-hisp/non-white/non-black 0.000025 12.5%

All infants (< 1 year) 0.000065 32.6% Nursing infants 0.000040 20.2% Non-nursing infants 0.000075 37.4% Children 1-6 yrs 0.000073 36.5% Children 7-12 yrs 0.000025 12.3%

Females 13-19 (not preg or nursing) 0.000011 5.4% Females 20+ (not preg or nursing) 0.000017 8.6% Females 13-50 yrs 0.000017 8.4% Females 13+ (preg/not nursing) 0.000017 8.5% Females 13+ (nursing) 0.000022 11.2%

Males 13-19 yrs 0.000011 5.3% Males 20+ yrs 0.000015 7.5% Seniors 55+ 0.000020 10.0%

Children 1-2 yrs 0.000107 53.5% Children 3-5 yrs 0.000063 31.3% Children 6-12 yrs 0.000027 13.3% Youth 13-19 yrs 0.000011 5.4% Adults 20-49 yrs 0.000014 7.1% Adults 50+ yrs 0.000020 9.8% Females 13-49 yrs 0.000015 7.4%

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### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 61 of 62 Attachment 17: Results File – ETU Cancer Analysis – Food Only U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for METIRAM - ETU (1994-98 data) Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM Files\Metiram\ETUChronicmetiramPRIASept2006foodonly.R98 Adjustment factor #2 used. Analysis Date 09-27-2006/15:02:44 Residue file dated: 09-27-2006/14:45:48/8 Q* = 0.0601 COMMENT 1: food only

=============================================================================== Total exposure by population subgroup

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Total Exposure

----------------------------------- Population mg/kg Lifetime risk Subgroup body wt/day (Q*= .0601)

-------------------------------------- ------------- ------------- U.S. Population (total) 0.000018 1.08E-06

U.S. Population (spring season) 0.000018 1.05E-06 U.S. Population (summer season) 0.000018 1.07E-06 U.S. Population (autumn season) 0.000018 1.07E-06 U.S. Population (winter season) 0.000019 1.14E-06

Northeast region 0.000019 1.16E-06 Midwest region 0.000018 1.08E-06 Southern region 0.000015 9.30E-07 Western region 0.000021 1.27E-06

Hispanics 0.000021 1.27E-06 Non-hispanic whites 0.000018 1.09E-06 Non-hispanic blacks 0.000015 8.81E-07 Non-hisp/non-white/non-black 0.000020 1.18E-06

All infants (< 1 year) 0.000051 3.05E-06 Nursing infants 0.000035 2.11E-06 Non-nursing infants 0.000057 3.41E-06 Children 1-6 yrs 0.000067 4.02E-06 Children 7-12 yrs 0.000021 1.24E-06

Females 13-19 (not preg or nursing) 0.000008 4.67E-07 Females 20+ (not preg or nursing) 0.000013 7.74E-07 Females 13-50 yrs 0.000013 7.57E-07 Females 13+ (preg/not nursing) 0.000013 7.63E-07 Females 13+ (nursing) 0.000016 9.82E-07

Males 13-19 yrs 0.000007 4.43E-07 Males 20+ yrs 0.000011 6.60E-07 Seniors 55+ 0.000016 9.43E-07

Children 1-2 yrs 0.000100 6.03E-06 Children 3-5 yrs 0.000056 3.39E-06 Children 6-12 yrs 0.000022 1.34E-06 Youth 13-19 yrs 0.000008 4.54E-07 Adults 20-49 yrs 0.000010 6.09E-07 Adults 50+ yrs 0.000015 9.17E-07 Females 13-49 yrs 0.000011 6.37E-07

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### Metiram Dietary Exposure Assessment DP Number: 326753 PC Code: 014601



## Page 62 of 62 Attachment 18: Results File – ETU Cancer Analysis – Food and Water U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for METIRAM - ETU (1994-98 data) Residue file name: C:\Documents and Settings\colinger\My Documents\Mancozeb\FF DEEM Files\Metiram\ETUChronicmetiramPRIASept2006foodpluswater.R98 Adjustment factor #2 used. Analysis Date 09-27-2006/15:14:46 Residue file dated: 09-27-2006/14:46:41/8 Q* = 0.0601 COMMENT 1: food plus water

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Lifetime risk Subgroup body wt/day (Q*= .0601)

-------------------------------------- ------------- ------------- U.S. Population (total) 0.000022 1.35E-06

U.S. Population (spring season) 0.000022 1.32E-06 U.S. Population (summer season) 0.000023 1.36E-06 U.S. Population (autumn season) 0.000022 1.33E-06 U.S. Population (winter season) 0.000023 1.40E-06

Northeast region 0.000023 1.41E-06 Midwest region 0.000022 1.35E-06 Southern region 0.000020 1.18E-06 Western region 0.000026 1.57E-06

Hispanics 0.000026 1.57E-06 Non-hispanic whites 0.000022 1.35E-06 Non-hispanic blacks 0.000019 1.13E-06 Non-hisp/non-white/non-black 0.000025 1.51E-06

All infants (< 1 year) 0.000065 3.92E-06 Nursing infants 0.000040 2.43E-06 Non-nursing infants 0.000075 4.49E-06 Children 1-6 yrs 0.000073 4.39E-06 Children 7-12 yrs 0.000025 1.48E-06

Females 13-19 (not preg or nursing) 0.000011 6.54E-07 Females 20+ (not preg or nursing) 0.000017 1.04E-06 Females 13-50 yrs 0.000017 1.01E-06 Females 13+ (preg/not nursing) 0.000017 1.02E-06 Females 13+ (nursing) 0.000022 1.35E-06

Males 13-19 yrs 0.000011 6.39E-07 Males 20+ yrs 0.000015 8.98E-07 Seniors 55+ 0.000020 1.20E-06

Children 1-2 yrs 0.000107 6.43E-06 Children 3-5 yrs 0.000063 3.76E-06 Children 6-12 yrs 0.000027 1.59E-06 Youth 13-19 yrs 0.000011 6.46E-07 Adults 20-49 yrs 0.000014 8.58E-07 Adults 50+ yrs 0.000020 1.18E-06 Females 13-49 yrs 0.000015 8.84E-07

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