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Form Approved . O .M .B. No . 2070-0012 . Approval Expires 10-31-96 . U.S. ENVIRONMENTAL PROTECTION AGENCY AGENCY.I;1WONLY

Date of receipt

~ PREMANUFACTURE ``~ 09

~ NOTICE

:s

Company Sviti1T.ed

4

!~'' [10

a be

in the PremanufactureNotice _a.%&

GENERAL INSTRUCTIONS TS 4M J 11 H 0 0 3

• You must provide all information requested in this form to the extent that it is known to or reasonably ascertainable by you . Make reasonable estimates if you do

not have actual data .

• Before you complete this form, you should read the "Instructions Manual for Premanufacture Notification" ( the Instructions Manual is available from the Toxic

Substances Control Act (TSCA) Information Se rv ice by calling 202-554-1404, or faxing 202-554-5603).

• If a user fee has been remi tted for this notice (40 CFR 700.45), indicate in the boxes above the TS-user fee identification number you have generated . Remember,

your user fee ID number must also appear on your corresponding fee remittance, which is sent to EPA, Washington Financial Management Center (3303), P.O.

360399M, Pi ttsburgh, PA 15251-6399, Attn. TSCA User fee.

Part I-GENERAL INFORMATION TEST DATA AND OTHER DATA

You must provide the currently correct Chemical Abs tracts (

CA) Name of the new You are required to submit all test data in your possession or control and to chemical substance, even if you claim the identity as con fi denti al . You may authorize provide a desc

another person to submit ri ption of all other data known to or reasonably asce rtainable by chemical iden tity informa ti on for you, but your submission will you, if these data are related to the health and environmental effects on th not be complete and the review will not begin unti e l EPA receives this information . A le tt

in support of your submission should reference your TS user fee iden er manufacture, processing, distribution in commerce, use, or disposal of the new tification number.

You must submit an o ri ginal and two copies of this noti ce including all test data . If you chemical substance . Standard literature citations may be submi tt ed for data in the

claimed any informa tion as confidential, a single sanitized copy must also be submitted. open scientific literature . Complete test data (w ri tten in EnQlish) not summari es

of data. must be submitted if they do not appear in the open literature . You should

clearly identify whether test data is on the substance or on an analog . Also, th e

Part II-HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE chemical composition of the tested mate rial should be characte rized. Following

are examples of test data and other data . Data should be submitted according to

If there are several manufacture, processing, or use opera tions to be described in Part II, the requirements of §720.50 of the Premanufacture Notification Rule (40 CFR

sec tions A an d B of this no ti ce, reproduce the sec tions as needed. Part 720).

Part III - LIST OF ATTACHMENTS Test Data ( Check Below any included in this no ti ce )

Attach additi onal sheets if there is not enough space to answer a ques ti on fully . Label each • Environmental fate data El Yes • Other data

El Yes

con tinuati on sheet with the corresponding sec tion heading. In Pa rt III, list these

at tachments, any test data or other data and an y opti onal informati on included in the no ti ce . • Health effects data

El Yes Risk assessments

• Environmental effects data El Yes Structure/activity relationships

OPTIONAL INFORMATION • PhysicaUChemical Pr operti es• E] Yes Test da ta not in the possession

You may include an y information that you want EPA to consider in evaluating the new or con

tr ol ofthe submi tter 1:1

subst an ce . On page I I of this form, space has been provided for you to describe ' A physical and chemical prope rties worksheet is located on the last page of this form . polluti on preven tion and recycling information you may have regarding the new substance .

TYPE OF NOTICE (Check Only One)

So-called "binding" boxes are included throughout this form for you to indicate you r

willingness to be bound to cer tain statements you make in this sec tion, such as use,

produc ~ PMN (Premanufacture Noti ce) tion volume, protec tive equipment . . . This opti on is intended to reduce delays that

routinely accompan y the development of consent orders or Signi fi cant New Use Rules .

Except in the case of exempti on applications (such as TMEA, LVE, LOREX) where © INTERMEDIATE PMN (submitt ed in sequence with final product PMN) certain information provided in such notifi ca tion is binding on the submi tter when the

Agency approves the exemp

by itself prohibit the submi

ti on applica tion, checking a binding box in this noti ce does not ❑ SNUN ( Significant New Use No ti ce) tter from later deviating from the infom~ati on (except chemical

identity) reported in the form .

© TMEA (Test Marketing Exemp tion Application)

CONFIDENTIALITY CLAIMS

❑ LVE (Low Volume Exemption) @ 40 CFR 723 .50(c)(1)

You may claim any information in this no ti ce as confiden tial. To assert a claim on the

form, mark (X) the confiden ti al box next to the information that you claim as confiden tial . © LOREX(Low Release/Low Exposure Exempti on) (a_) 40 CFR 723 .50(c)(2) To assert a claim in an attachment, circle or bracket the information you claim as

confiden

a sanitized

tial

version

. If you

of the

claim informa

notice, (including attachments)

tion in the no tices as confidential, you

. For addi tional instruc

must also provide

tions on LOREX Modi

® LVE Modification ~ fi cation

claiming informa tion as confi denti al, read the Instructions Manual .

IS THIS A CONSOLIDATED PMN? ~ Yes 1° 7r~r ;r•r

~ Mark (x) if any information in this no tice is claimed as con ti al.' i•'' ~ ' t'Ij

ofA~cals or polymers 1

(Prenotice Communica ti on # required, enter # on page 3)

J.t ; :s J

EPA FORM 7710-25 (Rev . 5-95) Replaces previous editions of EPA Form 7710-25 .

,~27i7~5
PMN Page 2 ; Page 2 of 1 8 -11111•'IZEDp COPY

.

Public reporting burden for this collection of information is estimated to average 110 hours per response, including time for reviewing

instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of

information . Send comments regarding the burden estimate or any other aspect of this collection of information, including suggestions for

reducing this burden, to Director, Collection Strategies Division (2822), U .S. Environmental Protection Agency, 1200 Pennsylvania Ave ., N .W.,

Washington, D.C. 20460; and to the Office of Management and Budget, Paperwork Reduction Act (2070-0012), Washington, D .C. 20503.

CERTIFICATION -- A Printed copy of this signature page, with original signature, must be submitted

I certify that to the best of my knowledge and belief:

1 . The company named in Part I, section A, subsection I a of this notice form intends to manufacture or import for a

commercial purpose, other than in small quantities solely for research and development, the substance identified in Part I,

Section B.

2 . All information provided in this notice is complete and truthful as of the date of submission .

3 . I am submitting with this notice all test data in my possession or control and a description of all other data known to or

reasonably ascertainable by me as required by §720 .50 of the Premanufacture Notification Rule .

Additional Certification Statements :

If you are submitting a PMN, Intermediate PMN, Consolidated PMN, or SNUN, check the following user fee certification

statement that applies:

Q The Company named in Part I, Section A has remitted the fee of $2500 specified in 40 CFR 700 .45(b), or

❑ The Company named in Part 1, Section A has remitted the fee of $1000 for an Intermediate PMN (defined @ 40 CFR

700.43) in accordance with 40 CFR 700 .45(b), or

❑ The Company named in Part I Section A is a small business concern under 40 CFR 700 .43 and has remitted a fee of $ l00

in accordance with 40 CFR 700 .45(b).

If you are submitting a low volume exemption (LVE) application in accordance with 40 CFR 723 .50(c)(1) or a Low release

and low exposure exemption (LoRex) application in accordance with 40 CFR 723 .50(c)(2), check the following certification

statements:

❑ The manufacturer submitting this notice intends to manufacture or import the new chemical substance for commercial

purposes, other than in small quantities solely for research and development, under the terms of 40 CFR 723 .50 .

❑ The manufacturer is familiar with the terms of this section and will comply with those terms; and

❑ The new chemical substance for which the notice is submitted meets all applicable exemption conditions .

❑ If this application is for an LVE in accordance with 40 CFR 723 .50(c)(1), the manufacturer intends to commence

manufacture of the exempted substance for commercial purposes within 1 year of the date of the expiration of the 30 day

review period.

The accuracy of the statements you make in this notice should reflect your best prediction of the anticipated facts regarding the chemical substanc e

desc ribed herein . Any knowing and willful misinterpretation is subject to criminal penalty pursuant to IS USC 1001 . Confidential Signature an tl orized 0 cial (Original Signature Required) Date

Signatureofagent - (ifa'able) Date

EPA FORM 7710-25 (Rev. 5-95) Page 2
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Part 1 -- GENERAL INFORMATION

Section A -- SUBMITTER IDENTIFICATION ConfiMark the "Con fidential" box next to any subsection you claim as con fidential dential Ia . Person Name of authorized official Positio n

Submi tt

Notice (

ing Richard Henrich Manager, Regulatory

in U .S .) Affairs ~

Company

Great Lakes Chemical

Mailing address (number and street)

P .O . Box 220 0

City, State Postal Code

West Lafayette, IN 47996-2200

b . Agent

applicable)

( if Name of authorized official Position ~

Company

Mailing address ( number and street )

City, State Postal Code Telephone ( include area code)

c

Joint Submi

. If you are submitting this notice as pa

tter ( if Name of authorized

rt

official Positio

of a joint submission, mark (X) this box . ~

n

applicable)

Company

Mailing address (number and street) City, State

Province, Count ry Postal Code Telephone (include countr y or area code)

2 . Technical Name of authorized official Position

Contact (in

U. S .) Richard Henrich Manager, Regulatory Affairs ~

Company

Great Lakes Chemical Corporation

Mailine address ( number and street)

P .O . Box 220 0

City, State Postal Code Telephone( in cl ude area code)

West Lafayette, IN 47996 ( 765) 497-6114

3 . If you have had a prenotice communication ( PC) concerning this notice and

EPA assign ed a PC Number to the notice, enter the number

. Mark(X) ---~ ❑

if none E

10

4 . If you previously submitted an exemption application for the chemica l

substance covered by this notice, enter the exemption number assi gned by Mark(X) ► EPA. If you previously submitted a PMN for this substance enter the PMN if non

number assigned by EPA (i .e e . withdrawn or incomplete). ~

5 . If you have submitted a notice of Bona fide intent to manufacture or impo rt

for the chemical substance covered by this notice, enter the notice number Mark

assigned by EPA .

(X) 10

0

if non e

6 .

I . ~ Manufacture 1 2 . Import Type of Notice - Mark (X) 1 Only I ~ Only I 3. Both

Binding Option El Binding Option

Mark (X) ~ Mark (X)

EPA FORM 7710-25 ( Rev. 5-95) Page 3
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Part I -- GENERAL INFORMATION - Continued

Section B - CHEMICAL IDENTITY INFORMATION : You must provide a currently correct Chemical Abstr acts ( CA) name of the substance based on the ninth

Collective Index 9CI of CA nomenclature rules and conventions .

Mark ( X) the "Confidential" box next to any item you claim as confidential

Complete either item I (Class I or 2 substances) or 2 (Polymers) as approp riate. Complete all other items .

If another pe rson will submit chemical identity information for you (for either Item I or 2), mark (X) the box at the right. Confi -

Identify the name, company, and address of that person in a continuation sheet . ❑ dential

I . Class I or 2 chemical substances ( for de finitions of class I and class 2 substances, see the Instructi ons Manual )

a

b

. Class of substance

. Chemical name (Currently correct Chemical Abstracts

- Mark (X) I E] Class

(

I or 2 ❑ Class 2 ~

CA) Name that is consistent with TSCA Inventory listings for similar substances. For ~

Class I substances a CA Index Name must be provided . For Class 2 substances either a CA Index Name or CA Preferred Name must be provided , which ever is appropriate based on CA 9CI nomenclature rules and conventions) .

Ethane, 2-bromo-1,1-difluoroc . Please identify which method you used to develop or obtain the specified chemical identity information repo rted in this notice : ( check one).

❑ Method 1(CAS Invento ry Expert Se rv ice - a copy of the Identi fication Q Method 2 (Other Source)

report obtained from the CAS Inventory Expe rt Se rv ices must be

submi tt ed as an att achment to this notice )

d. Molecular formula CBI CAS Regist

ry Number ❑

C2H3BrF2

❑

(if a number alread y

exists for the substance)

359-07-9

e. For a class I substance, provide a complete and correct chemical structure diagram. For a class 2 substance, provide a correct representative or

❑

part ial chemical structure diagram, as complete as can be known, if one can be reasonably asce rtained. Please see the E-PMN Instruction Manual for

discussion of "native format" diagram software which can be helpful in reviewing your substance .

F

I

F-CH-CH2-Br

❑ Mark (X) this box if you attach a continuation sheet .

EPA FORM 7710-25 (Rev 5-95) Page 4
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For a class 2 substance - (1) List the immediate precursor substances with their respective CAS Registry Numbers. (2) Describe the nature ofthe reaction or process .

(3) Indicate the range of composition and the typical composition (where appropriate) .

e. (1) List the immediate precursor substances with their respective

Name (CAS #)

CAS Registry Numbers . Confidential

This page intentionally left blank .

❑

e . (2) Desc ri be the nature of the reaction or process .

❑

e. (3) Indicate the range of composition and the typical composition (where appropriate) .

10

❑

Mark (X) this box if you att ach a continuation sheet .

EPA FORM 7710-25 (Rev . 5-95) Page 4a

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Part I -- GENERAL INFORMATION -- Continued

Section B - CHEMICAL IDENTITY INFORMATION -- Continue d

2 . Polymers ( For a defi nition of polymer, see the Instructions Manual .) Confidential

a. Indicate the number-average weight of the lowest molecular weight composition of the polymer you intend to manufacture

Indicate maximum weight percent of low molecular weight species (not including residual monomers, reactants, or solvents) below 500 an

. ~

d

below 1,000 absolute molecular weight of that com osition .

Describe the methods ofmeasurement or the basis for your estimates : GPC Other U :(Specify below)

(i) lowest number average molecular weight

: This page intentionally left blank .

(ii) maximum weight % below 500 molecular weight :

(iii) maximum weight % below 1000 molecular weight :

❑ Mark ( X) this box if you attach a continuation sheet .

b . You must make separate con fi dentiality claims for monomer or other reactant identity, composition information, and residual information . Mark (X) the

"Confidential" box next to any item you claim as confidentia l

(1) - Provide the speci fic chemical name and CAS Regist ry Number (if a number exists) of each monomer or other reactant used in the manufacture of

the polymer .

(2) - Mark (X) this column if entry in column (I) is con fi dential .

(3) - Indicate the typical weight percent of each monomer or other reactant in the polymer .

(4) - Choose "yes" fr om drop down menu if you want a monomer or other reactant used at two weight percent or less to be listed as pa rt of the polymer

description on the TSCA Chemical Substance Inventory .

(5) - Mark (X) this column if entries in columns (3) and (4) are confidential .

(6) - Indicate the maximum weight percent of each monomer or other reactant that may be present as a residual in the polymer as manufactured for

commercial purposes.

(7) - Mark (X) this column if entry in column (6) is confidential .

Monomer or other reactant and CAS Regist ry Number Confi- Typical Include in Confi- Maximum Confidential composition identity dential residual dential

(1) (2) (3) (4) (5) (6) (7

% %

)

[:::]

. 0 %% ❑0 %% 0

❑

°

❑

F] %

1:1

❑

%

F] ❑

%

E] L~

❑

%

❑E]

%

❑

%

L~ -1

%

L~A % ~

~ % ~ % ~

% ~ % ~

~ % %

❑ Mark (X) this box if you attach a continuation sheet .

EPA FORM 7710-25 (Rev . 5-95) Page 5

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c . Please identify which method you used to develop or obtain the specified chemical identity information repo rted in this notice (check one) . CBI

Method I (CAS Invento ry Expert Se rv ice - a copy of the identification repo rt ❑ Method 2 (other source )

obtained from CAS Inventory Expert Serv ice must be submitted as an attachment to this notice )

d . The currently correct Chemical Abstracts (CA) name for the polymer that is consistent with TSCA Invento ry listings for similar polymers.

This page intentionally left blank

. ~

CAS Registry Number ( if a number already exists for the substance )

e . Provide a correct representative or pa rt ial chemical structure diagram, as complete as can be known, if one can be reasonably ascertained . . Please

see the E-PMN Instruction Manual for discussion of "native format" diagram software which can be helpful in reviewing your substance .

E:] Mark ( X) this box if you attach a continuation sheet .

EPA FORM 7710-25 (Rev . 5-95) Page 5a

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Part I -- GENERAL INFORMATION -- Continued

Section B -- CHEMICAL IDENTITY INFORMATION -- Continued

3 . Impurities

(a) - Identify each impuri ty that may be reasonably anticipated to be present in the chemical substance as manufactured for commercial purpose . Provide

the CAS Registry Num ber if available . If there are unidentified impurities, enter "unidentified. "

(b) - Estimate the maximum wei ht % of each impurity. If there are unidentifi ed impurities, estimate their total wei ht % .

Impuri ty and CAS Registry Number Maximum Confi -

percent dential

(a) (b)

o,a ~

x

o,0 0 0

❑ Mark ( X) this box if you a ttach a continuation sheet .

4. Synonyms - Enter any chemical synonyms for the new chemical identi fi ed in subsection I or 2. Con6-

2-Bromo-1, 1-difluoroethane dential

BDFE ❑

❑ Mark ( X) this box if you att ach a continuation sheet .

5 . Trade identification - List trade names for the new chemical substance identi fi ed in subsection I or 2 .

2-Bromo-1,1-dif_uoroethane ❑

BDFE

❑ Mark (X) this box if you att ach a continuation sheet .

6. Generic chemical name - If you claim chemical identify as confidential, you must provide a generic name for your substance that reveals

the specific chemical identi ty of the new chemical substance to the maximum extent possible . Refer to the

TSCA Chemical Substance Invento ry , 1985 Edition, Appendix B for guidance on developing generic names.

❑ Mark (X) this box if you a ttach a continuation sheet .

7 . Byproducts - Describe any byproducts resulting from the manufacture, processing, use, or disposal of the new chemical substance . Provide the CAS Registry

Number if available .

Byproduct CAS Registry Number ConfiNone known ~

(1) (2) dential

~

Mark (X) this box if you a ttach a continuation sheet .

EPA FORM 7710-25 ( Rev. 5-95) Page 6

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Part I -- GENERAL INFORMATION -- Continued

Section C -- PRODUCTION, IMPORT, AND USE INFORMATION :

Mark (X) the "Confidential" box next to any item you claim as confidential.

1 . Production volume -- Estimate the maximum production volume during the first 12 months of production . Also estimate the maximum

production volume for any consecutive 12-month period during the first three years of production . Estimates should be on 100% new chemical

substance basis. For a Low Volume Exemption application, if you choose to have your notice reviewed at a lower production volume than

10,000 kg/yr, specify the volume and mark (x) in the bindin box. Ifgranted, you are bound to this volum e

Maximum first 12-month production (kg/yr) Maximum 12-month production (kg/yr) Confi- Binding

(100% new chemical substance basis) (100% new chemical substance basis) dential Optionk (x )

a] =

2 . Use Information--You must make separate confidentiality claims for the description of the category of use, the percent of production volume devoted to each

category, the formulation of the new substance, and other use information . Mark (X) the "Confidential" Box next to any item you claim as confidential .

a . (1) --Describe each intended category of use of the new chemical substance by function and application . (2) --Mark (X) this column if entry column (I) is

confidential business information (CBI). (3) --Indicate your willingness to have the information provided in column (1) binding . (4) --Estimate the percent of total

production for the first three years devoted to each category of use . (5) --Mark (X) this column if entry in column (4) is confidential business information (CBI) . (6) --

Estimate the percent of the new substance as formulated in mixtures, suspensions, emulsions, solutions, or gels as manufactured for commercial purposes at sites under

our control associated with each category of use . (7) --Mark (X) this column if entry in column (6) is confidential business information (CBI) . (8) --Indicate % of

product volume expected for the listed "use" sectors . Mark more than one box if appropriate . Mark (X) to indicate your willingness to have the use type provided in (8)

binding . (9) --Mark (X) this column if en (ies) in column (8) is (are) confidential business information (CBI).

Category of use (1) (by function and application i .e . a CBI Binding Prod- CBI %in CB1 % of substance expected per use CBI

dispersive dye for finishing polyester fibers) Option uction Formu g

~t' % lation ()

(2) (3) (4) (5) (6) (7) Stte- Cons- Indus- Corn- Binding (9)

Itmued tuner triad meraal Option

Chemical intermediate %

~

%

% % [

:1 El11 % %

% %

% %

% %

% %

* If you have identified a "consumer" use, please provide on a continuation sheet a detailed description of the use(s) of this chemical substance in consumer products.

In addition include estimates of the concentration of the new chemical substance as expected in consumer products and describe the chemical reactions by which this

substance loses its identity in the consumer product .

Mark (X) th is box if you attach a continuation sheet .

b . Generic use If you claim any category of use description in subsection 2a as confidential, enter a generic description of that category . Read the Instruction

description Manual for examples of generic use descriptions.

Mark (X) this box if you attach a continuation sheet .

3. Hazard Information -- Include in the notice a copy of reasonable facsimile of any hazard warning statement, label, material safety data sheet, or other Binding

information which will be provided to any person who is reasonably likely to be exposed to this substance regarding protective equipment or practices for option

the safe handing, transport, O port, use, or disposal of the new substance List in part III hazard information you include.

Z

Mark (X) this box if you attach hazard information . ~

EPA FORM 7710-25 (Rev . 5-95) Page 7

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Part II-- HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE

Section A -- INDUSTRIAL SITES CONTROLLED BY THE SUBMITTER Mark ( X) the "Confidential" box next to any item you

claim as confidentia l

Complete section A for each type of manufacture, processing, or use operation involving the new chemical substance at industrial sites you

control . Importers do not have to complete this section for operations outside the U.S . ; however, you may still have repo rting requirements if

there are further industrial processing or use operations after import . You must describe these operations: See instructions manual

1 . Operation description Confia . Identity -- Enter the identity of the site at which the operation will occur . dential

Name

Fic I

Site address ( number and street )

City, County, State, ZIP cod e

I IF--

If the same operation will occur at more than one site, enter the number of sites . Identify th e

additional sites on a continuation sheet, and if any of the sites have significantly different ❑

production rates or operations, include all the information requested in this section for thos e

sites as a ttachments.

❑ Mark (X) this box if you attach a continuation sheet.

b . Type -- ~

Mark (X) ❑ Man ufacturing ❑ Processing ❑ Use

c . Amount and Duration -- Complete 1 or 2 as appropriat e

Maximum kg/batch (ioo^i ne ., chenucai Hours/batch Batches/year

substance)

❑

I . Batch

Maximum kg/day (1 oo^i new che-cal Hours/day Days/year

substance) V

2 . Continuous /►

d. Process description

(1) Diagram the major unit operation steps and chemical conversions

❑ Mark (X) to indicate your willingness to have your process description binding

. Include interi m storage and transpo

. ~

rt containers (specify- e.g . 5 gallon pails, 55 gallon

drum, rail car, tank truck, etc .).

(2) Provide the identi ty , the approximate weight ( by kg/day or kg/batch on a 100% new chemical substance basis), and ent ry point of all start ing materials and

feedstocks (including reactants, solvents, catalysts, etc .), and of all products, recycle streams, and wastes. Include cleaning chemicals (note frequency if not

used daily or per batch .).

(3) Identify by number the points of release, including small or intermi ttent releases, to the environment of the new chemical substance . If releasing to two media

at the same step, assign a second release number for the second medium .

Mark (X) this box if you attach a continuation sheet.

EPA FORM 7710-25 (Rev . 5-95) Page 8

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Confidentia l

Fx-1

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Part II-- HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE -- Continued

Section A -- INDUSTRIAL SITES CONTROLLED BY THE SUBMITTER -- Continued

2 . Occupational Exposure -- You must make separate confidentiality claims for the description of worker activity, physical form of the new chemical substance, number of

works exposed, and duration of activity. Mark (X) the "Confidential" box next to any item you claim as confidential .

(1) --Describe the activities (i .e . bag dumping, tote filling, unloading drums, sampling, cleaning, etc .) in which workers may be exposed to the substance .

(2) --Mark (X) this column if entry in column (1) is confidential business information (CBI).

(3) -- Describe any protective equipment and engineering controls used to protect workers.

(4) and (6) -- Indicate your willingness to have the information provided in column (3) or (5) binding .

(5) -- Indicate the physical form(s) of the new chemical substance (e .g ., solid: crystal, granule, powder, or dust) and % new chemical substance (if part of a mixture) at the

time of exposure.

(7) --Mark (X) this column if entry in column (5) is confidential business information (CB1) .

(8) -- Estimate the maximum number of workers involved in each activity for all sites combined .

(9) --Mark (X) this column if entry in column (8) is confidential business information (CBI) .

(10) and (11) -- Estimate the maximum duration of the activity for any worker in hours per day and days per year.

(12) --Mark (X) this column if entries in columns (10) and (11 are confidential business information (CBI) .

Worker activity CBI Protective Equipment/ Binding Physical Binding CBI # of CBI Maximum duration CBI

forms(s)

(i .e ., bag dumping, filling drums) Engineering Controls Option and % new option Workers Hrs/day Days/y r

Mark (x) substance Mark (x) Exposed

(1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12)

Pre-start-up Safety glasses/goggles, None

equipment check & chemical resistant

inert gas purge gloves (as required) .

Process start-up, Safety glasses/goggles . None

operation, and shut- (Respirator and

down chemical resistant

clothing & glove s

: ~ -.t..i . . .. ... . .O

El Mark (X) this box if you attach a continuation sheet.

EPA FORM 7710-25 (Rev. 5-95) 9

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PMN Page 9a ; Page 13 of 1 8

3 . Environmental Release and Disposal -- You must make separate confidentiality claims for the release number and the amount of the new chemical substance

released and other release and disposal information . Mark ( X) the "Confidential" box next to each item you claim as confidential .

( 1) --Enter the number of each release point identified in the process description, part 11, section A, subsection ]d(3).

( 2) --Estimate the amount of the new substance released (a) directly to the environment or (b) into control technology (in kg/day or kg/batch).

(3) --Mark (X) this column if entries in columns ( 1) and (2) are confidential business information (CBI) .

(4) --Identify the media (stack air, fugitive air (optional-see Instruction Manual), surface water, on-site or off-site land or incineration, POTW, or other (specify)) to

which the new substance will be released from that release point .

(5) -- a . Desc ri be control technology, if any, and control efficiency that will be used to limit the release of the new substance to the environment. For releases

disposed of on land, characterize the disposal method and state whether it is approved for disposal of RCRA hazardous waste . On a continuation sheet, for

each site describe any additional disposal methods that will be used and whether the waste is subject to seconda ry or tert iary on-site treatment. b. Estimate the

amount released to the environment after control technology (in kg/day).

(6) --Mark (X) this column if entries in columns (4) and ( 5) are confidential business information (CBI) .

(7) --Identify the destination(s) of releases to water. Please supply NPDES (National Pollutant Discharge Elimination System) numbers for direct discharges or

NPDES numbers of the POTW (Publicly Owned Treatment Works) . Mark (X) if the POTW name or NPDES # is confidential business information CB .

Release Amount of new CBI Medium of Control technology and efficiency ( you may wish to optionally attach CB

Number substance released release efficiency data )

(1) (2a) (2b) eg szckav Binding

(3) (4) (5a) tvtXrk (5b) (6)

This page intentionally

left blank . See PMN Page

11 .

(7) Mark (X) the destination(s) of releases to water. NPDES # CBI

❑ POTW--provide

name(s)

❑

❑ Navigable waterway-- ❑

provide name(s)

❑ Other--Specify

❑

❑ Mark ( X) this box if you attach a continuation sheet.

EPA FORM 7710-25 (Rev . 5-95) Page 9a

~3
p. 14

PMN Page 10 ; Page 14 of 18 JITIZED COPY

Part II- HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE - Continued

Section B -- INDUSTRIAL SITES CONTROLLED BY OTHER S

Complete section B for typical processing or use operations involving the new chemical substance at sites you do not control . Importers do not have to complete this section for

operations outside the U .S . ; however, you must report any processing or use activities after import . See the Instructions Manual . Complete a separate section 8 jor each type of

processing, or use operation involving the new chemical substance . If the same operation is performed at more than one site describe the typical operation common to these

sites. Identify additional sites on a continuation sheet.

1(a). Operation Description -- To claim information in this section as confidential, circle or bracket the specific information that you claim as confidential .

(1) -- Diagram the major unit operation steps and chemical conversions, including interim storage and transport containers (specify - e .g . 5 gallon pails, 55 gallon drums, rail

cars, tank trucks, etc). On the diagram, identify by letter and briefly describe each worker activity. (2) -- Either in the diagram or in the text field 1(b) below, provide the

identity, the approximate weight (by kg/day or kg/batch, on an I00% new chemical substance basis), and entry point of all feedstocks (including reactants, solvents and

catalysts, etc) and all products, recycle streams, and wastes. Include cleaning chemicals (note frequency if not used daily or per batch) . (3) -- Either in the diagram or in the

text field 1(b) below, identify by number the points of release, including small or intermittent releases, to the environment of the new chemical substance . (4) Please enter

the # of sites (remember to identify the locations of these sites on a continuation sheet)

: CBI # of sites

❑

1(b). (Optional) This space is for a text description to clarify the diagram above . ❑

Mark (X) this box if you attach a continuation sheet .

EPA FORM 7710-25 (Rev . 5-95) Page 10
p. 1 5

PMN Page 10a ; Page 15 of 18 ' ; . JF + Z E ) GOf!',

,

2 . Worker Exposure/Environmental Release

(1) -- From the diagram above, provide the letter for each worker activity . Complete 2-8 for each worker activity described .

'(2) -- Estimate the number of workers exposed for all sites combined .

(4) -- Estimate the typical duration of exposure per worker in (a) hours per day and (b) days per yea r

(6) -- Describe physical form of exposure and % new chemical substance (if in mixture), and any protective equipment and engineering controls, if any, used to protect

workers.

(7) -- Estimate the percent of the new substance as formulated when packaged or used as a final product.

(9) -- From the process diagram above, enter the number of each release point. Complete 9-13 for each release point identified .

(10) -- Estimate the amount of the new substance released (a) directly to the environment or (b) into control technology to the environment (in kg/day or kg/batch) .

(12) -- Describe media of release i .e . stack air, fugitive air (optional-see Instructions Manual), surface water, on-site or off-site land or incineration, POTW, or other (specify)

and control technology, if any, that will be used to limit the release of the new substance to the environment .

(14) -- Identify byproducts which may result from the operation .

(3), (5), 8(1 1), 13) and (15) -- Mark (X) this column ifany of the proceeding entries are confidential business information (CBI) .

Letter u of CBI Duration Of CBI Protective Equip CBI . /Engineering Controls/Physical Form and/ % new substance % i n

Acti- Exposed ulation

of Workers Exposure Formvity

(1) (2) (3) (4a) (4b) (5) (6) (~) (8)

❑ ❑ ❑

❑ ❑ ❑

❑ ❑ ❑

❑ ❑ ❑

❑ ❑ ❑

Number Ne

Release Amount of CBI Media of Release & Control Technology CBI

w

Substance

Released

(9) (1 Oa) (]Ob) (11) (12) (13

❑ ❑

)

❑

❑ ❑❑

14) -- Byproducts: (15)

❑ ❑

❑

❑ Mark (X) this box if you attach a continuation sheet,

OPTIONAL POLLUTION PREVENTION INFORMATIO N

To claim information in the following section as confidential circle or bracket the specific information that you claim as confi dential.

In this section you may provide information not reported elsewhere in this form regarding your efforts to reduce or minimize potential risks

associated with activities surrounding manufacturing, processing, use and disposal of the PMN substance . Please include new information

pertinent to pollution prevention, including source reduction, recycling activities and safer processes or products available due to the new

chemical substance. Source reduction includes the reduction in the amount or toxicity of chemical wastes by technological modification,

process and procedure modification, product reformulation, raw materials substitution, and/or inventory control . Recycling refers to the

reclamation of useful chemical components from wastes that would otherwise be treated or released as air emissions or water discharges, or

land disposal . Descriptions of pollution prevention, source reduction and recycling should emphasize potential risk reduction subsequent to

compliance with existing regulatory requirements and can be either quantitative or qualitative . The EPA is interested in the information to

assess overall net reductions in toxicity or environmental releases and exposures, not the shifting of risks to other environmental media or nonenvironmental areas (e .g., occupational or consumer exposure) . In addition, information on the relative cost or performance characteristics of

the PMN substance to potential alternatives may be provided .

All information provided in this section will be taken into consideration during the review of this substance . See PMN Instructions

Manual and Pollution Prevention Guidance manual for guidance and examples.

EPA FORM 7710-25 (Rev. 5-95) Page l0a

1,~
p. 16

J1"IZE) (:C:'tj,

PMN Page 11 ; Page 16 of 1 8

Optional Pollution Prevention Information (Continued) Describe the expected net benefits, such as (1) an overall reduction in risk to

human health or the environment ; (2) a reduction in the volume manufactured ; (3) a reduction in the generation of waste materials

through recycling, source reduction or other means ; (4) a reduction in potential toxicity or human exposure and/or environmental

release ; (5) an increase in product performance, a decrease in the cost of production and/or improved operation efficiency of the new

chemical substance in comparison to existing chemical substances used in similar application ; or (6) the extent to which the new

chemical substance may be a substitute for an existing substance that poses a greater overall risk to human health or the environment .

CBI

11 Mark (X) this box if you att ach a continuation sheet.

EPA FORM 7710-25 (Rev. 5-95) Page 1 1

t6
p. 1 7

1171ZE'j COP"

PMN Page 12 ; Page 17 of 1 8

Part III -- LIST OF ATTACHMENTS

Attach continuation sheets for sections of the form and test data and other data (including physical/chemical properties and

structure/activity information), and optional information after this page . Clearly identify the attachment and the section of the form to

which it relates, if appropriate . Number consecutively the pages of any paper attachments. In the column below, enter the inclusive page

numbers of each attachment . Electronic attachments can be identified by filename .

Mark (X) the "Confidential" box next to any attachment name you claim as confidential . Read the Instructions Manual for guidance on

how to claim any information in an attachment as confidential . You must include with the sanitized copy of the notice form a sanitized

version of any a ttachment in which you claim information as confidential.

# Attachment name Attachment Filename Confi- Attachment

a e number(s) dential

1 Physical & Chemical Properties worksheet 18

EL

2 Material Safety Data Sheet 19 - 24 ❑

3 Acute Toxicological Properties Study 25 - 31 ❑

E]-

0-

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0-

El

~

~

0-

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~

~

~

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Mark (X) this box if you attach a continuation sheet. Enter the attachment name and number .

EPA FORM 7710-25 (Rev . 5-95) Page 12

i7
p. 1 8

PMN Page 13 ; Page 18 of 18 ~4 1 `771 ZE1) C ®P 3t

PHYSICAL AND CHEMICAL PROPERTIES WORKSHEET

To assist EPA's review of physical and chemical prope rties data, please complete the following worksheet for data you provide and

include it in the notice . Identify the propert y measured, the page of the notice on which the prope rty appears, the value of the prope rt y,

the units in which the prope rty is measured ( as necessary), and whether or not the proper ty is claimed as confidential . If the attachments

are electronic, give the att achment number (found on page 12) at (b). The physical state of the neat substance should be provided.

These measured propert ies should be for the neat ( 100% pure) chemical substance . Propert ies that are measured for mixtures or

formulations should be so noted (% PMN substance in _). You are not required to submit this worksheet ; however, EPA strongly

recommends that you do so, as it will simplify review and ensure that con fidential information is properly protected . You should submit

this worksheet as a supplement to your submission of test data. This worksheet is not a substitute for submission of test data .

Property Mark (X Page Value Measured o Confii r

,

number Estimate & -t

provide M

'a t

ark (X)

(a) (b) (c) M or E (d)

Physical state of neat substance ❑ (s) ❑(l) ID(g) ❑

Vapor pressure

Temperature °C F-1 Torr E]

Density/relative density ❑ g/cm3 ~

Solubility

@

❑

Temperature °C F~

Solvent L

Solubility in water Temperature °C 0% g/L ❑

Melting temperature E:1 Oc

Boiling / sublimation temperature ton pressure FK-1 °C M ~

Pa

Spectra

Dissociation

Octanol

rticle size

/ water

dist

constant

partition

ri bution

coefficient

❑ ❑

❑ ❑

❑ ❑

❑ ~

Volatilization

Volatilization

pH concentration

Henry's Law constant

from water

from soil

❑ ❑

❑ ❑

❑ ❑

❑ ❑

Adsorption

Flammability

Explodability

/ coefficient

❑ ❑

❑ ❑

❑ ~

Other

Other -

- Specify

Specify ❑ ❑

El Q

~ Mark ( X) this box if you attach a con ti nuation sheet. Enter the attachment name and number.

ATTACHMENT

PAGE 13

Ig
P. 19

Attachment #2

Page 19

MATERIAL SAFETY

Great Lakes Chemical Corporation DATA SHEET

MSDS Number: 00301 Effective Date : 04/14/2003

Product Name: 2-Bromo-1,1-difluoroethane Page : 1 of 6

Ii SECTION I - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

Product Name: 2-Bromo-l,l-difluoroethane

Manufacturer: Great Lakes Chemical Corporation

Address: P.O. Box 2200 City: West Lafayette

State: Indiana Zip: 47996-2200

Emergency Telephone Number : 1-800-949-5167

Information Telephone Number: 1-765-497-6100 Fax: 1-765-497-6123

Chemtrec Phone : 1-800-424-9300; Internationally call 703-527-3887

Effective Date: 04/14/2003 Supercede Date: 10/27/98

MSDS Prepared By: Regulatory Affairs Department/Great Lakes Chemical Corporation

Synonyms: 1-Bromo-2,2-difluoroethane; 2,2-Difluoroethyl bromide

Product Use: Research and Development

Chemical Name : 2-Bromo- 1, 1 -difluoroethane

Chemical Family: Hydrobromofluorocarbo n

Additional Information

No information availabl e

SECTION II - COMPOSITION/INFORMATION ON INGREDIENTS

INGREDIENT NAME CAS No. % EXPOSURE LIMITS

2-Bromo- 1, 1 -difluoroethane 359079 >99 .5 Y (Hazardous)

Not established (OSHA PEL TWA)

Not established (OSHA PEL STEL)

Not established (OSHA PEL CEIL)

Not established (ACGIH TLV TWA)

Not established (ACGIH TLV STEL)

Not established (ACGIH TLV CEIL)

*Indented chemicals are components of previous ingredient .

Additional Inform a tion

No information available

Ii SECTION III - HAZARDS IDENTIFICATION

Emergency Overview: Colorless liquid

Odor not availabl e

The toxicological properties of this material have not been determined .

This material may be harmful by ingestion, inhalation or skin

absorption .

Causes mucous membrane and upper respiratory tract irritation .

Causes skin irritation .

Causes eye irritation .

Relevant Routes of Exposure: Ingestion, inhalation and skin absorption

Signs and Symptoms of

Overexposure : General reddening and irritation to the skin and eyes, mucous

membrane irritation, upper respiratory tract irritation . Medical Conditions Generally

Aggravated By Exposure: None reporte d

Potential Health Effects: See Section XI for additional information .

Eyes: Causes eye irritation.

11
p. 20

Attachment #2

Page 20

MATERIAL SAFETY DATA SHEET

MSDS Number: 00301 Effective Date: 04/14/2003

Product Name: 2-Bromo-1,1-difluoroethane Page: 2 of 6

SECTION III - HAZARDS IDENTIFICATION

Skin: Causes skin irritation.

May be harmful if absorbed through skin .

Ingestion: May be harmful if swallowed .

Inhalation: May be harmful if inhaled .

Chronic Health Effects: None known

Carcinogenicity

NTP: No ACGIH: No

IARC: No OTHER: No

OSHA: No

Additional Information

No information availabl e

SECTION IV - FIRST AID MEASURES

. .

Eyes: Flush with large volumes of water for at least 15 minutes. Get

medical attention .

Skin: Wash with large volumes of soap and water for at least 15 minutes . If

irritation develops, get medical attention .

Ingestion: If conscious, give person 1 to 2 glasses of water . Get medical attention

immediately .

Inhalation: Remove person to fresh air. Get medical attention .

Antidotes: No information availabl e

Notes to Physicians and/o r

Protection for First-Aiders: No information available

Additional Information

No information availabl e

Ii SECTION V - FIRE FIGHTING MEASURES

Flammable Limits in Air (% by

Volume): Not available

Flash Point: Not available

Autoignition Temperature : Not availabl e

Extinguishing Media : All conventional media are suitable.

Fire Fighting Instructions: Wear a self-contained breathing apparatus and protective clothing to

prevent skin and eye contact in fire situations .

Unusual Fire and Explosio n

Hazards: Under fire conditions, toxic and irritating fumes may be emitted .

Flammability Classification : Non-flammable liquid

Known or Anticipated

Hazardous Products of Hydrogen bromide and/or bromine

Combustion: Hydrogen fluoride

Carbon monoxide and carbon dioxide

Additional Information

No information availabl e

SECTION VI - ACCIDENTAL RELEASE MEASURES

. 1 1,

Accidental Release Measures: Contain spill.

Wearing appropriate personal protective equipment, collect spill with

the aid of an inert absorbent and place in suitable labeled containers

for disposal

.t.0
p. 21

Attachment #2

MATERIAL SAFETY DATA SHEET Page 21

MSDS Number: 00301 Effective Date: 04/14/2003

Product Name: 2-Bromo-1,1-difluoroethane Page: 3 of 6

SECTION VI - ACCIDENTAL RELEASE MEASURE S

Personal Precautions: See Section VIII . ,

Environmental Precautions: Avoid releasing to the environment .

Additional Information

No information availabl e

Ii SECTION VII - HANDLING AND STORAGE

Handling: Use appropriate personal protection equipment .

Avoid eye, skin and clothing contact .

Do not breathe mist or vapor .

Avoid repeated and prolonged contact.

Keep away from heat, sparks and flame .

Storage: Storein a cool, dry, well-ventilated area away from incompatible

materials.

Keep container tightly closed .

Protect containers against damage.

Store away from heat, sparks, and flame .

Other Precautions: No information available

Additional Information

No information availabl e

Ii SECTION VIII - EXPOSURE CONTROLS/PERSONAL PROTECTION

Engineering Controls: Adequate general ventilation is recommended when handling to

control airborne levels.

Ventilation Requirements: Use local exhaust to minimize misting and vapor.

Use mechanical ventilation for general area control .

Personal Protective Equipment

Eye/Face Protection: Chemical safety glasses with side shields or chemical safety goggles

Skin Protection: Chemical resistant glove s

Clothing designed to minimize skin contact

Respiratory Protection: Wear a NIOSH/MSHA approved organic/acid gas cartridge respirator

if misting or vapor occurs .

Consult the OSHA respiratory protection information located at

29CFR 1910 .134 and the American National Standard Institute's

Practices of Respiratory Protection Z88.2.

Other Protective

Clothing or Equipment: No information available

Exposure Guidelines: See Section II. Work Hygienic Practices: Wash thoroughly after handling .

Wash contaminated clothing before reuse.

Additional Informatio n

No information availabl e

Ii SECTION IX - PHYSICAL & CHEMICAL PROPERTIES

Appearance: Colorless liquid Percent Volatile : Not available

Boiling Point: 57.3 degrees C pH Value: Not available

Bulk Density: Not available pH Concentration:

Color: Colorless Physical State: Liquid

Decomposition Temperature : Not available Reactivity in Water: Not water reactive

Evaporation Rate: Not available Saturated Vapor

Concentration: Not available

o'•f
p. 22

Attachment #2

Page 22

MATERIAL SAFETY DATA SHEET

MSDS Number: 00301 Effective Date : 04/14/2003

Product Name: 2-Bromo-1,1-difluoroethane Page: 4 of 6

. •

SECTION IX - PHYSICAL & CHEMICAL PROPERTIES

Freezing Point: Not available Softening Point: Not available

Heat Value: Not available Solubility in Water: Not available

Melting Point: Not available Specific Gravity or

Density (Water=l) : 1.8

Molecular/Chemical Formula: C2H3BrF2 Vapor Density: Notavailable

Molecular Weight: 144 .95 Vapor Pressure : Not available

Octanol/Water Partition Viscosity: Not available

Coefficient: Not availabl e

Odor: Not available Volatile Organi c

Compounds: Not available

Odor Threshold: Not available i Water/Oil

Distribution Not available

Coefficient :

Particle Size : Not available Weight Per Gallon: Not available

Additional Information

No information available

SECTION X - STABILITY AND REACTIVITY

Stability: Stable under normal conditions of handling and use .

Conditions to Avoid: Ignition sources

Incompatibility With Othe r

Materials: Strong oxidizers

Hazardous Decompositio n

Products: Thermal decomposition may produce the following :

Hydrogen bromide and/or bromin e

Hydrogen fluoride

Carbon monoxide and carbon dioxide

Hazardous Polymerization: Will not occur

Conditions to Avoid: None

Additional Information

No information available

SECTION XI - TOXICOLOGICAL INFORMATIO N

VALUE (LD50 OR LC50) ANIMAL ROUTES COMPONENTS

>2,000 mg/kg Rat Acute Oral 2-Bromo-l,l-difluoroethane

Toxicological Information:

The toxicological properties of this material have not been fully determined .

May be harmful by inhalation, ingestion or skin absorption .

Causes mucous membrane and upper respiratory tract irritation .

Causes skin irritation .

Causes eye irritation.

Other acute and chronic health hazards, as well as target organs, are unknown .

As with all dusts, inhalation of air concentration levels above the PNOR may cause irritation and adverse

lung effects.

Additional Information

No information available

oC~
p. 23

Attachment #2

Page 23

MATERIAL SAFETY DATA SHEET

MSDS Number: 00301 Effective Date: 04/14/2003

Product Name: 2-Bromo-1,1-difluoroethane Page: 5 of 6

•

SECTION XII - ECOLOGICAL INFORMATIO N

Ecological Information: Avoid releasing to the environment .

Additional Informatio n

No information available

SECTION XIII - DISPOSAL CONSIDERATIONS

Disposal Considerations: Dispose of waste at an approved chemical disposal facility in

compliance with all current Local, State/Province . Federal/Canadian

laws and regulations .

Additional Information

No information available

SECTION XIV - TRANSPORT INFORMATION

U.S. DOT

Proper Shipping Name: Not regulated

Hazard Class : N/A ID Number: N/A

Packing Group

Special Provisions

:

:

N/A Labels

N/A Packaging Exceptions

: N/A

: N/A

Non-Bulk Packaging: N/A Bulk Packaging: N/A

Passenger Air/Rail Limit: N/A Air Cargo Limit: N/A

Vessel Stowage: N/A Other Stowage: N/A

Reportable Quantity: N/A

AIR - ICAO OR IATA

Proper Shipping Name: Not regulated

Hazard Class: N/A ID Number: N/A

Subsidiary Risk: N/A Packing Group: N/A

Hazard Labels: N/A Packing Instructions: N/A

Air Passenger Limit Per Packing Instruction -

Package

Air Cargo Limit

:

Per Special

N/A Cargo: N/A

Provisions N/A

Package : N/A Code:

WATER - IMDG

Proper Shipping Name: Not regulated

Hazard Class: N/A ID Number: N/A

Packing Group: N/A Subsidiary Risk: N/A

Medical First Aid Guide

Code: N/A

Additional Information

No information available

Ii SECTION XV - REGULATORY INFORMATION

U.S. Federal Regulations:

This material is not on the TSCA Inventory and is not intended for commercial use . This research and

development chemical should only be used by, or directly under the supervision of, a technically qualified

individual.

In compliance with Section 611 of the Clean Air Act : WARNING: Contains bromodifluoroethane, a substance which harms public health and environment by

destroying ozone in the upper atmosphere

a3
p. 24

Attachment #2

Page 24

MATERIAL SAFETY DATA SHEET

MSDS Number : 00301 Effective Date: 04/14/2003

Product Name: 2-Bromo-1,1-difluoroethane Page: 6 of 6

SECTION XV - REGULATORY INFORMATIO N

State Regulations:

None known

International Regulations:

This material (or each component) is listed on the following inventories :

None known

Canadian WHMIS Hazard Class and Division = D.2 .b

SARA Hazards:

Acute: Yes Chronic: No

Reactive: No Fire: No

Pressure : No

Additional Information

The above regulatory information represents only selected regulations and is not meant to be a complete list.

SECTION XVI - OTHER INFORMATION

NFPA Codes:

Health: NR Flammability: NR

Reactivity: NR Other: NR

HMIS Codes: * indicates chronic health hazard.

Health: NR Flammability: NR

Reactivity: NR Protection: NR

Label Statements: Not availabl e

Other Information: Abbreviations :

(L) = Loose bulk density in g/m l

LOEC = Lowest observed effect concentratio n

MATC = Maximum acceptable toxicant concentration

NA = Not available

N/A = Not applicable

NL = Not limited

NOAEL = No observable adverse effect level

NOEC = No observed effect concentration

NOEL = No observable effect leve l

NR = Not rated

(P) = Packed bulk density in g/m l

PNOC = Particulates Not Otherwise Classified

PNOR = Particulates Not Otherwise Regulated

REL = Recommended exposure limi t

TS = Trade secret

Additional Information

Information on this form is furnished solely for the purpose of compliance with OSHA's Hazard

Communication Standard, 29CFR 1910 .1200 and The Canadian Environmental Protection Act, Canada

Gazette Part II, Vol . 122, No. 2 and shall not be used for any other purpose .

Revision Information :

General review and update .

Section I - Synonyms

Section XI - Acute Oral LD50

.~,~
p. 25

Attachment #3

Page 25

11ANITIZEU C~P'y

STUDY ID: 000047

PAGE ]

Study Titl e

I -BROMO-2,2-DIFLUOROETHANE (BDFE) : ACUTE TOXICOLOGICAL

PROPERTIES

Author(s)

Study Completion Date

12 April 2000

Performing Laborator y

Laboratory Project Study ID

000047

Ad
p. 26

Attachment #3

Page 26

'-' A'AITIZEa COPY

STUDY ID: 000047

PAGE 2

TEST MATERIAL

Chemical Name : 1-Bromo-2,2-difluoroethane

Physical State : liquid

Sample Reference:

CAS #: 359-07-9

A sample of 1-Bromo-2,2-difluoroethane was submitted b y

for evaluation of acute oral and dermal

toxicity, and skin and eye irritation .

METHODS AND RESULTS

In the acute oral toxicity test, three fasted female Fischer 344 rats received 500 mg/kg of test

material as a 20% mixture in distilled water by single dose gavage . All rats were normal

throughout the duration of the study. All of the rats gained weight during the study. Body

weight data are summarized in Table 1 .

Three fasted female Fischer 344 rats received 2000 mg/kg of neat test material by single dose

gavage . Clinical signs consisted of various combinations of salivation, perineal urine soiling,

decreased activity, and incoordination . All clinical signs were resolved by test day 3, and no

further clinical signs were observed throughout the duration of the study . All of the rats gained

weight during the study . Body weight data are summarized in Table 1 . Therefore, under the

conditions of this study, the LD50 for female Fischer 344 rats was greater than 2000 mg/kg .

In the skin irritation test, one male and one female rabbit were dosed with 0 .5 ml of neat test

material under an occluded wrap for four hours. The backs of the rabbits were clipped with an

electric clipper approximately 24 hours prior to test initiation . The animals were bandaged for 4

hours after application of the test material to provide occlusion and prevent grooming of the

application site. Four hours after application, the bandages were removed and the application

sites were wiped with a damp disposable towel to remove any residual test substance . The

application sites were graded and neither rabbit had signs of skin irritation throughout the study

period. The test was terminated after 72 hours . There was no effect on the body weights . Body

weight and skin irritation data are summarized in Table 2.

The eye irritation test included instillation of 0.1 ml of neat test material into each conjunctival

sac of one male New Zealand White rabbit that had been screened for ocular defects and

irritation 24 hours prior to dosing . The right eye was dosed and washed out after approximately

30 seconds. The left eye was dosed and not washed for approximately 1 hour. An ocular

anesthetic was administered to both eyes after moderate discomfort was observed in the right eye .

A6
p. 27

Attachment #3

Page 27

Al : IZE COPY

STUDY ID STUDY ID: 000047 : 000047

PAGE 3

Slight conjunctivitis was noted in both eyes immediately after dosing. One hour after dosing, the

left eye had slight conjunctivitis and the right eye had moderate conjunctivitis . The ocular

irritation diminished over time. The conjunctivitis in the left eye was resolved by 48 hours, and

the conjunctivitis of the right eye was resolved 7 days after dosing . The test was terminated at

this time . Body weight data are summarized in Table 3 .

In the acute dermal toxicity test, rats had their trunk clipped 24 hours prior to dosing. A single

application of 2000 mg/kg of the neat test material was applied for 24 hours under a gauze patch

to the backs of three female Fischer 344 rats. The gauze patch was covered with elastic wrap and

tape. Residual test material was wiped off with a damp disposable towel when the bandage was

removed 24 hours after application . All animals survived the test period. Two rats had re d

periocular soiling and lacrimation on test day 2 . No further clinical signs were observed

throughout the duration of the study . All rats given 2000 mg/kg gained or maintained body

weight during the study. The data for the individual rabbits are presented in Table 4 . Therefore,

under the conditions of this study, the estimated acute dermal LD50 for female Fischer 344 rats

was greater than 2000 mg/kg.

oG ~
p. 28

Attachment #3

+~ l"' E ZED COPY Page 28

STUDY ID: 000047

PAGE 4

TABLE 1

1-BROMO-2,2-DIFLUOROETHANE (BDFE) : ACUTE TOXICOLOGICAL PROPERTIES

Acute Oral Toxicity Study

Individual Rat Body Weights (grams)

Female 500 mg/k g

Animal

Number Test day 1 Test day 2 Test day 8 Test day 15

99A6973 114.2 128.2 142.8 148.9

99A6974 123.5 136.4 145.8 157.6

99A6975 115.4 128.2 146.0 156. 5

Female 2000 mg/kg

Animal

Number Test day 1 Test day 2 Test day 8 Test day 15

OOA 1027 116.2 128.6 134.2 149.1

OOA 1028 113 .5 122.6 137.7 148.9

OOA 1029 115 .7 126.6 141.3 149. 3

oZ~
p. 29

Attachment #3

Page 29

41 71ZE D G 0 WY

STUDY ID: 00004 7

PAGE 5

TABLE 2

1-BROMO-2,2-DIFLUOROETHANE (BDFE): ACUTE TOXICOLOGICAL PROPERTIES

Prima ry Dermal Irritation Study

Individual Rabbit Body Weights (kilograms)

'0

Animal Body Weight Body Weight

Number Test day 1 Test day 4

99A6969 (male) 2.834 2.918

99A6955 (female) 3.528 3.65 1

Erythema / Edema

Animal

Number 4 hours 24 hours 48 hours 72 hours

99A6969 (male) 0/0 0/0 0/0 0/0

99A6955 (female) 0/0 0/0 0/0 0/0

None = 0 Slight = 1

~9
p. 30

Attachment #3

Page 30

171 Z E J C;®~'Y

STUDY ID: 000047

PAGE 6

TABLE 3

1-BROMO-2,2-DIFLUOROETHANE (BDFE): ACUTE TOXICOLOGICAL PROPERTIES

Prima ry Eye Irritation Stud y

Individual Rabbit Body Weights (kilograms)

Animal Borjy Weight Body Weight

Number Test day l Test day 8

99A4249 (male) 3.592 3.620

Left eye/ Right eye

Animal Number: 99A4249 (male )

Response Initial 1 hour 24 hours 48 hours 72 hours 7 days

Discomfort 1/4 NA NA NA NA NA

Conjunctiva 3/3 3/4 2/3 1/3 1/3 1/1

Cornea-before stain 1/1 1/1 1/1 1/1 1/1 1/1

Cornea-after stain NA 1/1 1/1 1/1 1/1 1/1

Iris 1/1 1/1 1/1 1/1 1/1 1/1

Grading Scale: NA=Not applicable ; 1= No effect; 2 = Very slight; 3 = slight ;

4= Moderate ; 5 = Severe; 6 = Very severe.

30
p. 31

Attachment #3

Page 31

A1".'iZE .) (;0P'~ STUDY ID: 000047

PAGE 7

TABLE 4

1-BROMO-2,2-DIFLUOROETHANE (BDFE) : ACUTE TOXICOLOGICAL PROPERTIES

Acute Dermal Toxicity Study

Individual Rat Body Weights ( grams)

2000 mg/kg

Animal

Number Test day 1 Test daY2 Test daY8 Test day 15

OOA 1011 194.0 177.2 193.3 193.9

00A 1012 211 .7 196.2 210.1 210.4

00A 1013 208 .4 191.3 210.1 211. 5

3~
2

Public-reporting burden for this collection of information is estimated to average 110 hours per response, including time for reviewing

instructions. searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of

information . Send comments regarding the burden estimate or any other aspect of this collection of information, including suggestions for

reducing this burden, to Chief, Information Policy Branch, PM-223, U .S. Environmental Protection Agency, 401 M. St., S.W., Washington, D .C.

20460 ; and to the Office of Management and Budget, Paperwork Reduction Act (2070-0012), Washington, D .C. 20503 .

CERTIFICATION

I certify that to the best of my knowledge and belief:

1 . The company named in Part I, section A, subsection 1 a of this notice form intends to manufacture or import for a

commercial purpose, other than in small quantities solely for research and development, the substance identified in Part I,

Section B.

2 . All information provided in this notice is complete and truthful as of the date of submission . ❑

3 . 1 am submitting with this notice all test data in my possession or control and a description of all other dataTflown ta7ar

reasonably ascertainable by me as required by §720 .50 of the Premanufacture Notification Rule .

.,~

Additional Certification Statements :

If you are submitting a PMN, Intermediate PMN, Consolidated PMN, or SNUN, check the following user fee cZification

statement that applies: ""-

❑ The Company named in Part I, Section A has remitted the fee of $2500 specified in 40 CFR 700 .45(b), or

❑ The Company named in Part I, Section A has remitted the fee of $1000 for an Intermediate PMN (defined @ 40 CFR

700.43) in accordance with 40 CFR 700 .45(b), or

❑ The Company named in Part I Section A is a small business concern under 40 CFR 700 .43 and has remitted a fee of $100

in accordance with 40 CFR 700 .45(b).

If you are submitting a low volume exemption (LVE) application in accordance with 40 CFR 723 .50(c)(1) or a Low release

and low exposure exemption (LoRex) application in accordance with 40 CFR 723 .50(c)(2), check the following certification

statements:

❑ The manufacturer submitting this notice intends to manufacture or import the new chemical substance for commercial

purposes, other than in small quantities solely for research and development, under the terms of 40 CFR 723 .50.

❑ The manufacturer is familiar with the terms of this section and will comply with those terms ; and

❑ The new chemical substance for which the notice is submitted meets all applicable exemption conditions .

❑ If this application is for an LVE in accordance with 40 CFR 723 .50(c)(1), the manufacturer intends to commence

manufacture of the exempted substance for commercial purposes within 1 year of the date of the expiration of the 30 day

review period.

The accuracy of the statements you make in this notice should reflect your best prediction of the anticipated facts regarding the chemical substanc e

described herein . Any knowing and willful misinterpretation is subject to criminal penalty pursuant to 18 USC 1001 . Confidential

Signature and title of Authorized Offici 1, (Original Si ;areRequired) Date

~_~~

C a~ t G'~G°-•{~ C ._~`'-Cr-~ r L:

.r_ .__ ~r._ ._ -' :,C e.~

Signature of agent - (ifapplicable) Date

EPA FORM 7710-25 (Rev . 5-95) Page 2 L,27

1

75C

Y 2
p. 33

Part I -- GENERAL INFORMATION

Section A --SUBMITTER IDENTIFICATION ConfiMark O the "Confidential" box next to any subsection you claim as confidential dential

la. Person Name of authorized official Position

Submittin g

Notice (in U .S .) R. A. Wolcott Global Leader, Supply R&D

Company

Dow AgroSciences

Mailing address (number and street )

9330 Zionsville Road

City, State, ZIP Code

b . Agent (if Name of autho

Indianapolis,

ri zed official

IN 46268 J1

Positio n

applicable)

Company

Mailing address (number and street)

City, State, ZIP Code Telephone Area Code Number

c . If you are submitting this notice as part of a joint submission, mark (X) this box . ❑

Joint Submitter (if Name of authorized official Position

applicable)

Compan y

Great Lakes Chemical Corporation

Mailing address (number and street )

City, State, ZIP Code Telephone Area Code Number

2 . Technical Name of authorized official Position

Contact (in Linda C . Burgert

U.S.) Re ulato Specialist

Company

The Dow Chemical Company

Mailing address ( number and stre et)

1803 Building

City, State, ZIP Code Telephone Area Code Number

Midland, MI 989 636-1011

3 . If you have had a prenotice communication (PC) concerning this notice

and EPA assigned a PC Number to the notice, enter the number. Mark (X) -

if none

4 . If you previously submitted an exemption application for the chemica l

substance covered by this notice, enter the exemption number assigned by Mark (X) ►

EPA. If you previously submi tted a PMN for this substance enter the if non

~

e

PMN number assigned by EPA (i .e . withdrawn or incompktc) . ►

5 . If you have submi tted a notice of Bona fide intent to manufacture or import

for the chemical substance covered by this notice, enter the notice number Mark (X) ►

assigned by EPA. if none

1 . ® Manufacture 2. ❑ Import

6 . Type of Notice - Mark (X) Only Only 3. ❑ Both

❑ Binding Option ❑ Binding Optio n

Mark (X) Mark (X)

EPA FORM 7710-25 (Rev . 5-95) Page3

33
p. 34

Part II-- HUMAN EXPOSURE AND ENVIRONMENTAL RELEASE -- Continue d

Section B -- INDUSTRIAL SITES CONTROLLED BY OTHERS

Complete section B for typical processing or use operations involving the new chemical substance at sites you do not control . Importers do not have to complete this

section for operations outside the U .S . ; however, you must report any processing or use activities after import . See the Instructions Manual . Complete a separate

section B for each type of processing, or use operation involving the new chemical substance . If the same operation is performed at more than one site describe the

typical operation common to these sites. Identify additional sites on a continuation sheet .

1 . Operation Description -- To claim information in this section as confidential, circle or bracket the specific information that you claim as confidential .

(1) -- Diagram the major unit operation steps and chemical conversions, including interim storage and transport containers (specify - e .g. 5 gallon pails, 55 gallon

drums, rail cars, tank trucks, etc) . On the diagram, identify by letter and briefly describe each worker activity . (2) -- Provide the identity, the approximate weight

(by kg/day or kg/batch, on an 100% new chemical substance basis), and entry point of all feedstocks (including reactants, solvents and catalysts, etc) and all

products, recycle streams, and wastes. Include cleaning chemicals (note frequency if not used daily or per batch). (3) -- Identify by number the points of release,

including small or intermittent releases, to the environment of the new chemical substance . (4) Please enter the # of sites (remember to identify the locations of

these sites on a continuation sheet):

1

# of sites

See attached sheets for use process description, diagram, and mass balance .

10(a) Description

10(b) Diagram

10(c) Mass balanc e

® Mark (X) this box if you attach a continuation sheet.

2 . Worker Exposure/Environmental Release

(l) -- From the diagram above, provide the letter for each worker activity . Complete 2-8 for each worker activity described.

(2) -- Estimate the number of workers exposed for all sites combined .

(4) -- Estimate the typical duration of exposure per worker in (a) hours per day and (b) days per year.

(6) -- Describe physical form of exposure and % new chemical substance (if in mixture), and any protective equipment and engineering controls, if any, used to

protect workers.

(7) -- Estimate the percent of the new substance as formulated when packaged or used as a final product.

(9) -- From the process diagram above, enter the number of each release point. Complete 9-13 for each release point identified .

(10) -- Estimate the amount of the new substance released (a) directly to the environment or (b) into control technology to the environment (in kg/day or kg/batch).

(12) -- Describe media of release i .e. stack air, fugitive air (optional-see Instructions Manual), surface water, on-site or off-site land or incineration, POTW, or other

(specify) and control technology, if any, that will be used to limit the release of the new substance to the environment.

(14) -- Identify byproducts which may result from the operation .

(3), (5), (8), (11), (13) and (15) -- Mark (X) this column if any of the proceeding entries are confidential business information (CBI) .

Letter # of CBI Duration CBI Protective Equip . / % in CBI Release Amount of CBI Media of Release CBI

of Workers of Engineering Controls/ Form- Number New & Control

Act- Exposed Exposure Physical Form and % uiation Substance Technology

i

vtty new substance Release

d

(1) (2) (3) (4a) (4b) (5) (6) (7) (8) (9) (l0a) (l0b) (11) (12) (13)

A X X Goggles/gloves, Enginee rin g

Controls, Liquid, 99%

B X X X

C X X Goggles/gloves, liquid,

<0.01 %

1 X X

(14) -- Byproducts: (15)

X

Mark (X) this box if you attach a continuation sheet,

EPA Form 7710-25 (Rev . 5-95) Page 10

3~+
p. 35

~ 10. t1 ~ ~Cl I

S

10(a)

3S
p. 36

Cj- t\

Page 10(b )

36
p. 37

--___ - ~

PMN File 10(c) 12/2003

3 7