Exhibit
10.2


 


MASTER
SERVICES AGREEMENT


 


This Master Services
Agreement (the "Agreement") is made this 15th day of November, 2015 by and between Professional
Research Consulting, Inc. d/b/a PRC Clinical, a California Corporation with offices at 1111 Bayhill Drive, Suite 290, San
Bruno, California 94066 ("PRC Clinical or PRC") and Creative Medical Health, Inc., a Delaware Corporation
with business office at 2007 W Peoria Ave., Phoenix, AZ 85029 ("Sponsor").


 


WHEREAS,
Sponsor is in the business of developing, manufacturing and/or distributing pharmaceutical products, medical devices and/or biotechnology
products; and


 


WHEREAS,
PRC is a contract research organization engaged in the business of managing clinical research programs and providing clinical development
services and other services for the pharmaceutical, medical device and biotechnology industries; and


 


WHEREAS,
Sponsor and PRC desire to enter into this Agreement to provide the terms and conditions upon which Sponsor may engage PRC from
time to time to provide clinical development services in connection with certain clinical research studies of Sponsor's proprietary
products (each, a "Project"), in which case the terms and conditions for each such Project shall be set forth
in one or more written work orders to be agreed upon and signed and attached to this Agreement and incorporated herein by reference
(a "Work Order''); and


 


NOW,
THEREFORE, for good and valuable consideration contained herein, the exchange, receipt and sufficiency of which are acknowledged,
the parties agree as follows:


 


9.
Services.


 


9.4
Work Orders. In the event that the parties reach agreement with respect to the provision of Services for a Project, PRC and Sponsor
shall execute a Work Order with respect to such Services. Each Work Order shall set forth the nature and scope of the Services
to be performed and other specific details relating to the Services for each Project to be performed by PRC. Such Work Order shall
include, but not be limited to, an estimate of PRC's fees, pass-through costs, and third party vendor costs for such Services,
the deliverables (if any) for the Project, and such other terms and conditions as shall be deemed appropriate or necessary for
the performance of the Services. Sponsor agrees that the Work Order shall be executed by both parties before PRC commences work
under the Work Order, unless the parties otherwise agree in writing. Each fully executed Work Order shall be deemed to be attached
hereto and incorporated herein. The applicable Work Order and this Agreement shall constitute the entire agreement for
each Project. To the extent any terms set forth in a Work Order conflict with the terms set forth in this Agreement, the
terms of this Agreement shall control unless otherwise specifically set forth in the Work Order. As required by 21 C.F.R. §
312.52, the specific obligations relating to each Project that are being transferred to PRC by Sponsor shall be listed in
the applicable Work Order. Sponsor shall retain responsibility for all other activities related to the Project. Sponsor shall at
all times be considered the sponsor of the Project for the purpose of all laws, regulations, and regulatory authority requirements
applicable to the conduct of clinical trials. Sponsor shall be solely responsible for review, approval, and adoption of the clinical
study protocol for each Project.


 




    	PRC Clinical MSA/Sponsor	version APRIL 2015




     


    

  


1.2        Change
Orders. If Sponsor requests any changes to the scope of the Services for a particular Project from those set forth in the applicable
Work Order, or if the assumptions set forth in the budget for such Project contained in the applicable Work Order change, PRC shall
prepare a written change order reflecting such changes, including an estimate of any resulting adjustment to the timeline for the
performance of the Services under the Work Order and to the compensation schedule (a "Change
Order"). Once a Change Order is executed by both parties, such Change Order shall constitute an amendment to the
applicable Work Order and the Services shall thereafter constitute those Services set forth in the Work Order as amended by the
Change Order. Both parties agree to act in good faith and promptly when considering a Change Order requested by the other party.
Without limiting the foregoing, Sponsor agrees that it will not unreasonably withhold approval of a Change Order, even if it involves
a fixed price contract, if the proposed changes in budgets or time lines result from, among other appropriate reasons, forces outside
the reasonable control of PRC or changes in the assumptions upon which the initial budget or time lines were based, including,
but not limited to, the assumptions set forth in the budget or timelines. PRC reserves the right to postpone effecting material
changes in the Project's scope until such time as the parties agree to and execute the corresponding Change Order. For any Change
Order that affects the scope of the regulatory obligations that have been transferred to PRC, PRC and Sponsor shall execute a corresponding
amendment to the Transfer of Obligations Form. Sponsor shall file such amendment where appropriate, or as required by law or regulation.


 


1.3        Timelines
and Delays. PRC shall use commercially reasonable efforts to perform the Services within any timelines specified in the applicable
Work Order. However, Sponsor acknowledges that such timelines are estimates and assume the full cooperation of Sponsor, regulatory
authorities, Ethics Committees or Institutional Review Boards, investigative sites and investigators, and other third parties
not under PRC's control, and shall be subject to adjustment (including an adjustment in the fees and costs for the performance
of Services) if the work for the Services is delayed due to circumstances not attributable to PRC, such as the following: (a)
a failure by Sponsor to perform Sponsor's obligations with respect to the Study in a timely fashion, (b) a delay by Sponsor in
providing information or feedback requested by PRC, (c) amendments to the protocol for the Project that occur after the execution
of the applicable Work Order, (d) enrollment rates that are lower than anticipated, © changes in applicable regulatory requirements,
suspensions or other delays imposed by regulatory authorities, or (f) delays in obtaining required approvals from regulatory authorities,
Ethics Committees or Institutional Review Boards. Sponsor acknowledges that, if it materially delays or suspends performance of
the Services for more than fifteen (15) calendar days and such delay or suspension is unrelated to any act or omission by PRC
in violation of this Agreement, then the personnel and/or resources originally allocated to the delayed or suspended portion of
the Services may be re- allocated, and PRC will not be responsible for delays due to required re-staffing or re-allocation of resources.


 


If a Project
is delayed or suspended for more than 15 calendar days, Sponsor shall have the right to keep, at its expense, some or all of the
PRC personnel assigned to the Project assigned to the Project for the duration of the delay or suspension period. Sponsor shall
pay a fee for each such individual that remains assigned to the Project at Sponsor's request. Said personnel fees shall be invoiced
by PRC, and shall be due and payable by Sponsor upon receipt of invoice. If a Sponsor does not wish to retain any PRC personnel
for the duration of the delay or suspension, PRC shall have the right to reallocate any and all such personnel to other projects,
and Sponsor shall bear the costs, if any, of providing Project-specific training to replacement personnel assigned to the Project
once it resumes. If a Project is delayed or suspended for more than 90 days, either party may terminate the Work Order for such
Project upon written notice to the other party.


 




    	PRC Clinical MSA/Sponsor
	2	version APRIL 2015




     


    

 


1.4  Sponsor Cooperation. Sponsor shall forward to PRC in a timely manner all documents, materials and information in
Sponsor's possession or control necessary for PRC to conduct the Services. PRC shall not be liable to Sponsor nor be deemed to
have breached this Agreement for errors, delays or other consequences arising from Sponsor's failure to timely provide documents,
materials or information or to otherwise cooperate with PRC in order for PRC to timely and properly perform its obligations. Sponsor
shall provide PRC with all information available to it regarding known or potential hazards
associated with the use of any substances supplied to PRC by Sponsor, and Sponsor shall comply with all current legislation and
regulations concerning the shipment of substances by the land, sea or air.


 


Sponsor
will cooperate with PRC in providing information to PRC and taking such actions (including, If applicable, executing documents),
as are appropriate to achieve the objectives of this Agreement. Sponsor acknowledges and agrees that PRC's performance under this
Agreement is dependent on Sponsor's timely and effective cooperation with PRC. Accordingly, Sponsor acknowledges that any delay
by Sponsor may result in PRC being released from an obligation or schedule deadline or in Sponsor having to pay extra fees in order
for PRC to meet a specific obligation or deadline despite the delay. Sponsor shall comply with all applicable laws, rules and regulations
governing the performance of its obligations hereunder and the subject matter of this Agreement.


 


		2.	Compensation and Payment.



 


2.1         Charges
for Services. Sponsor shall pay PRC for all Services performed under this Agreement in accordance with the budget and payment
schedule for such Services set forth in the applicable Work Order (the "Budget"). Unless otherwise specified in
a Work Order, the Budget for each Project shall consist of line items specifying the work to be completed by PRC for the Project
and the rates for such work.


 


2.2         Pass-Through
Costs. The Budget for each Project shall include an itemized breakdown of the estimated out-of-pocket costs that will be incurred
by PRC in connection with the performance of Services for such Project including, without limitation, travel expenses (collectively,
the "Pass-Through Costs"). Sponsor shall reimburse PRC for all Pass-Through Costs, incurred in accordance with
the Budget, provided that such Pass-Through Costs are supported by written receipts or other documentation reasonably acceptable
to Sponsor. Sponsor acknowledges that some or all of the Pass-Through Costs set forth in any Work Order are an estimate based on
the scope of the Project, timelines, and information supplied by third parties, and that such costs cannot be predicted with complete
certainty at the outset of a


Project.


 


2.3         Third
Party Vendors. If applicable, PRC will provide a third party vendor budget in each Work Order. All third party vendor costs and
associated management fees invoiced to Sponsor shall be approved by Sponsor in advance and shall include documentation reasonably
acceptable to Sponsor.


 




    	PRC Clinical MSA/Sponsor
	3	version APRIL 2015




     


    

 


2.4         Invoices.
Unless otherwise provided in the Work Order, PRC shall invoice Sponsor on a monthly basis for Services and Pass-Through Costs incurred
and associated overhead and handling charges via electronic invoice sent to the Financial/Accounts Payable contact designated in
the applicable Work Order. Each such invoice shall itemize the Services performed and all Pass-Through Costs with supporting documentation
where indicated. Unless otherwise specified in the applicable Work Order, and subject to Section 2.5 below, Sponsor shall pay each
monthly invoice for Services and Pass-Through Costs within 25 days of receipt. PRC shall invoice Sponsor for third party vendor
costs and associated management fees separately, and all such invoices shall be paid by Sponsor within 5 days of receipt. PRC reserves
the right to charge interest in the amount of 1.5% per month for any undisputed invoiced amounts that have not been paid within
25 days of Sponsor's receipt of the applicable invoice.


 


2.5         Disputed
Invoices. Sponsor will notify PRC within 10 days of its receipt of an invoice submitted under Section 2.4 if it disputes such
invoice or any portion thereof. Sponsor shall provide, in writing, queries for PRC to address to allow full payment of any such
disputed invoice or disputed portion thereof within the original 25 day payment period. The parties will promptly discuss such
queries and formulate an action plan to resolve the issues. Billing queries generated by Sponsor will be addressed to the contact
person at PRC referenced in the applicable Work Order, and Sponsor and PRC will negotiate in a timely, good faith manner to resolve
billing queries. Any undisputed amounts shall be paid without delay pursuant to section 2.4


 


2.6         Exchange
Rate. All payments due hereunder in accordance with the Budget of the applicable Work Order shall be made by Sponsor in United
States Dollars ("USO"). The parties acknowledge and agree that all amounts
set forth in the Work Orders shall be in USD. If PRC incurs Pass-Through Costs or third party vendor costs under a Work Order in
a currency other than USO, such costs shall be invoiced to Sponsor and reimbursed to PRC at the USO equivalent of the expense paid
by PRC. The hourly labor fees contained in the Budget for each Work Order shall be fixed in USO, and will require no conversion.


 


2.7         Taxes.
The fees payable under any Work Order shall not, and shall not be construed to, include local, state, federal or foreign sales
and use taxes, such as Value Added Tax, if any, and any such taxes shall be assumed and paid by Sponsor.


 


2.8         Advance
and Fixed Fee Payments. If indicated in the applicable Work Order, Sponsor shall provide advance funding for certain projects.
The repayment schedule will be specified in the Work Order. This advance funding is needed to cover the cost of hiring staff and
making commitments with other vendors to service the Project. As such, should the Project terminate prematurely, the amount of
such advance payments would be forfeit by Sponsor. In the event that all Services are completed early relative to the timeline
described in the applicable Work Order, all remaining Fixed Fees will be immediately invoiced to and paid by Sponsor in accordance
with this Section 2.


 


2.9         Advance
Payment of Pass-Through Costs and Vendor Expenses. If indicated in the Work Order, and upon execution of a Work Order which
anticipated pass-through and/or third party vendor expenses, PRC will issue to Sponsor an invoice in an amount equal to an agreed
percentage of the total estimated Pass-Through Costs and third party vendor costs set forth in the Budget, including those Pass-Through
Costs consisting of payments to be made to investigators and investigative sites (such amount, the "Advance Payment").
Sponsor shall pay to PRC such Advance Payment within 20 days after its receipt of such invoice. For clarity, Sponsor shall
pay PRC for Pass-Through Costs and third party vendor expenses incurred on a Project in accordance with the Budget for such Project
on a pass-through basis and in accordance with the payment terms set forth in Sections 2.2 and 2.3. The amount of the Advance
Payment paid by Sponsor to PRC for a Project will be held by PRC until the completion or termination of the applicable Project
and credited against that portion of the final invoice(s) under the applicable Work Order that consist of Pass-Through Costs and
third party vendor expenses. In the event that the amount of the Advance Payment paid by Sponsor to PRC exceeds the amount due
by Sponsor to PRC for actual Pass-Through Costs and third party vendor expenses under the final invoice(s) under the applicable
Work Order, PRC shall refund to Sponsor an amount equal to the amount by which the Advance Payment exceeds the amount due by Sponsor
for actual Pass-Through Costs and third party vendor expenses under such final invoice(s).


 




    	PRC Clinical MSA/Sponsor
	4	version APRIL 2015




     


    

 


2.10         Inflationary
Adjustments. PRC shall be entitled upon 30 days' written notice to increase the rates applicable to the performance of Services
to include inflationary adjustments, which inflationary adjustments shall not exceed 5% of the labor rates applicable for the
prior calendar year under the Work Order. In the event that any such increase is made, the parties shall enter into a Change Order
to reflect such revised fees.


 


		3.	Term
                                         and Termination.



 


3.1         Term.
The term of this Agreement shall commence on the Effective Date and shall continue for three (3) years unless extended in a written
amendment to this Agreement signed by authorized representatives of both parties. Each Work Order shall be effective upon the
date signed by the last signatory thereto and shall terminate upon the completion of Services to be provided thereunder, unless
earlier terminated in accordance with this Section 3.


 


3.2         Termination
by Either Party. Either party may terminate this Agreement or any individual Work Order for any reason upon 30 days' prior
written notice to the other party. Termination of a Work Order shall terminate the corresponding Project.


 


3.3         Termination
for Material Breach. Either party may terminate this Agreement or a Work Order if the other party materially breaches the
terms of this Agreement or of such Work Order and such breaching party fails to cure the breach within 15 days after receipt of
written notice from the non-breaching party specifying the nature of such breach. The parties agree that non-payment by Sponsor
of an undisputed invoice shall be deemed a material breach of this Agreement. If PRC determines, in that its continued performance
of the Services contemplated by one or more Work Orders would constitute a potential or actual violation of regulatory or scientific
standards of integrity, then PRC may terminate the applicable Work Order(s) by giving written notice stating the effective date
(which may be less than thirty (30) days from the notice date) of such termination. Either party may terminate this Agreement
or any Work Orders immediately upon provision of written notice if the other party becomes insolvent or files for bankruptcy.
Any written termination notice shall identify the specific Work Order or Work Orders that are being terminated.


 


3.4         Effect
of Termination. The termination of this Agreement by either party shall automatically
terminate all Work Orders, unless otherwise agreed in writing. Upon the receipt or provision of a notice of termination of this
Agreement or a Work Order, PRC shall cooperate with Sponsor to provide for an orderly wind-down and/or transition of the Services
provided by PRC hereunder. Upon termination of this Agreement, Sponsor shall promptly pay PRC in full for all fees for Services
performed, Pass-Through Costs and third party vendor expenses, and associated administrative overhead and handling fees, incurred
up through the termination date as calculated in accordance with the provisions of this Agreement and the Budget in the applicable
Work Order. In addition, Sponsor shall reimburse PRC for all reasonable, future non cancelable obligations to third parties for
Pass-Through Costs and third party vendor expenses to be incurred in accordance with the Budget for the applicable Work Order.
Promptly after the date of termination or completion of a Work Order or this Agreement, PRC will submit to Sponsor an itemized
accounting of Services performed for the applicable Project, the Pass- Through Costs and third party vendor expenses incurred as
calculated in accordance with the provisions of this Agreement and the Budget in the applicable Work Order, the amount of any
non-cancellable obligations to third parties for Pass-Through Costs and third party vendor expenses that were to be incurred by
PRC in accordance with the Budget for each terminated Work Order, and the amount of payments received from Sponsor in order to
determine the amount of the balance owed by, or the overpayment to be refunded to, Sponsor. Any balance owed by, or any overpayment
to be refunded to, Sponsor will be paid or refunded within 25 days of receipt of such an itemized accounting. Sponsor shall pay
for all actual costs, including time spent by PRC personnel, incurred to complete activities associated with the termination and
close-out of affected Projects, including the fulfillment of any regulatory requirements.


 




    	PRC Clinical MSA/Sponsor
	5	version APRIL 2015




     


    

 


3.5  Provisions
Surviving Termination. The obligations of the parties contained in Sections 2, 3.4, 3.5, 4, 5, 7, 8.2, 9.2, 9.4, 9.5, 9.6,
9.8, 9.9, and 9.12 hereof shall survive termination of this Agreement.


 


		4.	Confidentiality.



 


4.1         Confidential
I nformation. Subject to the limitations set forth in Section 4.3, all information that (a) is provided by Sponsor to PRC
relating to a Project, (b) relates to a Project and is developed, generated, or obtained by PRC as a result of performing Services
under this Agreement, including, without limitation, Inventions (as defined in Section 5.2), shall, in each case, be deemed to
be "Sponsor Confidential Information". Subject to the limitations set forth in Section 4.3, (i) all information
pertaining to PRC's proposals, pricing, and quotations (except to the extent that such information incorporates Sponsor Confidential
Information), methods, standard operating procedures, and subcontractor information, including materials or technology owned or
licensed by PRC, that is disclosed to Sponsor or Sponsor's representatives, and (ii) all information regarding PRC's operations,
methods, and pricing, and all information that is or has been previously independently developed by PRC without the benefit of
any information provided by Sponsor, including PRC Property, and that is identified as confidential at the time of disclosure
to Sponsor, shall be deemed to be "PRC Confidential Information" under this Agreement. Sponsor Confidential Information
and PRC Confidential Information may be referred to herein individually and collectively as "Confidential Information".
For purposes of this Agreement, each party is the "Disclosing Party'' with respect to its own Confidential Information,
and a "Receiving Party" with respect to the Confidential Information of the other party.


 


4.2         Use
and Non-Disclosure of Confidential Information. The Receiving Party shall: (a) use the Disclosing Party's Confidential
Information solely for the purposes contemplated by this Agreement and for no other purpose without the prior written consent
of the Disclosing Party; (b) not disclose the Disclosing Party's Confidential Information to any third party except as
necessary in connection with the performance of activities under this Agreement without first obtaining the written consent
of the Disclosing Party; and (c) protect the confidentiality of the Disclosing Party's Confidential Information with at least
the same degree of care used to protect its own confidential and/or proprietary information from unauthorized use or
disclosure, but in no event with less than reasonable care. The Receiving Party will be permitted to furnish and otherwise
disclose the other party's Confidential Information to those of its employees, agents, contractors, and consultants who need
to know such Confidential Information in order to accomplish the purposes of this Agreement, provided that such personnel are
bound by obligations of confidentiality with respect to such Confidential Information substantially similar to those provided
herein. If the Receiving Party discloses the Disclosing Party's Confidential Information to a third party with the Disclosing
Party's permission as permitted herein, the Receiving Party shall ensure that all Confidential Information disclosed to such
third party is identified as confidential at the time of disclosure.


 




    	PRC Clinical MSA/Sponsor
	6	version APRIL 2015




     


    

 


4.3         Exceptions
to Confidential Information. The obligations of confidentiality set forth in Section 4.2 shall not apply to that part of the
Disclosing Party's Confidential Information which the Receiving Party is able to demonstrate by competent proof:


 


(9) was already
known to the Receiving Party, other than under an obligation of confidentiality, at the time of disclosure by the Disclosing Party;


 


(b) was generally
available to the public or otherwise part of the public domain at the time of its disclosure to the Receiving Party;




 


©
later became part of the public domain through no act or omission of the Receiving Party;


 


(d) was disclosed
to the Receiving Party without obligations of confidentiality with respect thereto, by a third party who had no obligation to
the Disclosing Party not to disclose such information to others without restriction; or


 


©
was independently developed by employees of the Receiving Party without use of or reference to the Disclosing Party's Confidential
Information.


 


4.4         Disclosure
Required by Law. The Receiving Party may disclose the Disclosing Party's Confidential Information without violating the obligations
of this Agreement to the extent that such disclosure is (a) required by a valid order of a court or other governmental body having
jurisdiction, (b) required by applicable law or regulation, (c) is necessary for filings with regulatory or governmental agencies
including, without limitation, the U.S. Securities & Exchange Commission and the FDA, or (d) in connection with prosecuting,
defending, or providing testimony in litigation, provided that the Receiving Party provides the Disclosing Party with reasonable
prior written notice of such disclosure when possible and, at the Disclosing Party's request and expense, makes a reasonable effort
to obtain, or to assist the Disclosing Party in obtaining, a protective order or other appropriate remedy preventing or limiting
the disclosure and/or requiring that the Disclosing Party's Confidential Information so disclosed be used only for the purposes
for which the law or regulation requires, for which the order was issued, for the applicable regulatory or governmental filing,
or for the applicable litigation.


 


4.5.         Return
of Confidential Information. At the Disclosing Party's request, the Receiving Party shall return all Confidential Information
provided by the Disclosing Party in documentary form
or, at the Disclosing Party's request, destroy all or such parts of the Disclosing Party's Confidential Information as the Disclosing
Party shall direct, including any copies thereof made by the Receiving Party. Notwithstanding the foregoing, the Receiving Party
may retain one (1) copy of the Disclosing Party's Confidential Information solely for archival purposes, subject to the ongoing
obligation to maintain the confidentiality of such information.


 




    	PRC Clinical MSA/Sponsor
	7	version APRIL 2015




     


    

 


		5.	Intellectual
                                         Property.



 


5.1         No
License. Each party agrees that neither party transfers to the other party by operation of this Agreement any patent right,
copyright right, trademark right or other intellectual property right of such party, except as may be specifically provided herein.


 


5.2         Sponsor
Property. PRC will promptly disclose to Sponsor all improvements, inventions, formulae, processes, techniques, work product,
know-how and data, whether or not patentable, that is generated, conceived, discovered or reduced to practice by PRC, its employees,
agents, or subcontractors, whether solely or jointly with others in the course of or as a direct result of the performance of
the Services under this Agreement, together with all intellectual property rights arising therefrom (collectively, "Inventions").
All Inventions and all deliverables will be the sole and exclusive property of Sponsor and shall be Sponsor Confidential
Information; provided that, the term "Inventions" does not include PRC Property (as such term is defined in Section
5.3) and improvements thereto. PRC hereby assigns and transfers to Sponsor all of PRC's right, title and interest in any and all
Inventions and agrees to take, at Sponsor's request and expense, all further acts reasonably required to convey full title in
the Inventions to Sponsor. Further, PRC will cause all of its personnel that perform Services hereunder to assign and transfer
to Sponsor all such personnel's right, title and interest in Inventions to Sponsor, and to take, at Sponsor's request and expense,
all further acts reasonably required to convey title in any such Invention to Sponsor.


 


5.3         PRC
Prooertv. "PRC Property" means inventions, processes, technology, know-how, trade secrets, and other assets (including,
without limitation, those related to data collection processes, data management processes, laboratory analyses procedures and
techniques, analytical methods, procedures and techniques, computer technical expertise and software (including codes) that have
been or are independently developed by PRC without the benefit of or access to any information provided by or on behalf of Sponsor
and that do not relate to the composition of matter, method of using, making or administering the drug that is the subject of
a Project. All PRC Property is the sole and exclusive property of PRC, and shall be PRC Confidential Information.


 


		6.	Representations
                                         and Warranties.



 


6.1         No
Inconsistent Obligations or Constraints. Each party represents and warrants that it is qualified and permitted to enter into this
Agreement and that the terms of this Agreement are not inconsistent with its other contractual arrangements. PRC warrants that
it is not constrained by any existing agreement in providing the Services to be performed under this Agreement. Sponsor agrees
that it will not enter into an agreement with a third party that would alter or affect the regulatory obligations delegated to
PRC in any Project without providing prior written notice to PRC.


 


6.2         Due
Authorization. The persons executing this Agreement represent and warrant that they have the full power and authority
to enter into this Agreement on behalf of each respective party.


 


6.3         Required
Licenses. Each party represents and warrants that, if applicable to a Project, it possesses all necessary licenses for use of
the MedDRA and WHO-Drug dictionaries in connection with such Project, and that it shall maintain all such licenses in full force
and effect during the term of this Agreement.


 




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	8	version APRIL 2015




     


    

 


6.4         Compli
ance with Applicabl e Laws. Each party represents and warrants that it shall comply with all laws and regulations applicable
to such party in connection with its activities under this Agreement.


 


6.5         No
Debarred Person. PRC represents and warrants that it and its personnel who perform any Services hereunder are not presently
debarred by the FDA pursuant to 21 U.S.C. § 335a. In addition, PRC represents and warrants that, to the best of its knowledge,
it has not engaged in any conduct or activity which could lead to debarment actions. If, during the term of this Agreement, PRC
discovers or receives notice that it or any personnel employed or retained by it to perform Services comes under investigation
by the FDA for a debarment action or is debarred, PRC shall promptly notify Sponsor of same.


 


6.6         Disclaimer
of Warranties. EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN THIS AGREEMENT, NEITHER SPONSOR NOR PRC MAKES ANY REPRESENTATIONS
OR EXTENDS ANY WARRANTI ES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING ANY EXPRESS OR IMPLIED WARRANTI ES OF MERCHANTABILITY,
TITLE OR FITNESS FOR A PARTICULAR PURPOSE.


 


		7.	Indemnification.



 


7.1         Sponsor
I ndemnity. Sponsor shall indemnify, defend and hold harmless PRC and its employees, affiliates, directors, officers, and
agents (collectively, the "PRC lndemnitees") from and against any
and all damages, liabilities, losses, costs and expenses of any kind or nature whatsoever, including, without limitation, reasonable
attorney's fees, expert witness and court costs (collectively, "Losses"), incurred in connection with any claim,
demand, action, or proceeding brought by a third party (each, a "Claim") arising from (a) any substance dispensed
or procedure administered in the course of a Project, or any other person's use, consumption, sale, distribution or marketing
of the drug that is the subject of a Project, including the harmful or otherwise unsafe effect of such drug, (b) the performance
of Services by PRC hereunder in compliance with the terms of this Agreement, (c) the infringement or misappropriation of a third
party's intellectual property rights by reason of the performance of the Services using the information supplied by Sponsor or
the Sponsor's drug, (d) a breach of the Sponsor's representations, warranties or obligations under this Agreement, or ©
the negligence, gross negligence or intentional misconduct on the part of Sponsor lndemnitees (as such term is defined
in Section 7.2 below) in connection with this Agreement; provided however, that Sponsor shall have no obligation of indemnity
hereunder with respect to a Claim to the extent that such Claim arises from (i) the negligence, gross negligence, or intentional
misconduct on the part of PRC or its employees, affiliates, or agents, or (ii) a breach of any of PRC's obligations, representations
or warranties under this Agreement.


 


7.2         PRC
lndemnitv. PRC shall indemnify, defend, and hold harmless Sponsor and its employees, affiliates, directors, officers, and agents
(collectively, the "Sponsor lndemnitees") from and against any and all Losses incurred in connection with any
Claim arising from (a} the negligence, gross negligence, or intentional misconduct on the part of any of the PRC lndemnitees in
connection with this Agreement, or (b) a breach of any of PRC's obligations, representations or warranties under this Agreement;
provided, however, that PRC shall have no obligation of indemnity hereunder with respect to any Claim to the extent that such
Claim arises from (i) the negligence, gross negligence,
or intentional misconduct on the part of Sponsor or its agents or representatives, or (ii) a breach of any of Sponsor's obligations,
representations, or warranties under this Agreement.


 




    	PRC Clinical MSA/Sponsor
	9	version APRIL 2015




     


    

 


7.3         Indemnification
Procedure. Each party's agreement to indemnify, defend, and hold harmless the other party and its respective indemnitees is
conditioned upon the indemnified party: (a) providing written notice to the indemnifying party of any claim, demand, or action
arising out of the indemnified activities within 30 days after the indemnified party has knowledge of such claim, demand, or action;
provided, however, that any failure on the part of an indemnified party to notify the indemnifying party of receipt of notice
of a claim shall relieve the notified party of its obligation to indemnify the notifying party for such claim under this Agreement
only to the extent that the notified party has been prejudiced by the lack of timely and adequate notice; (b) permitting the indemnifying
party to assume full responsibility and authority to investigate, prepare for, settle, and defend against any such claim, demand,
or action; (c) assisting the indemnifying party, at the indemnifying party's reasonable expense, in the investigation of, preparation
for and defense of any such claim, demand, or action; and (d) not compromising or settling such claim, demand, or action without
the indemnifying party's written consent.


 


7.4         limitation
of liability. In no event shall the liability of either party arising out of this Agreement exceed an amount equal to the total
Budget for the relevant Project. Further, in no event will either party be entitled to, nor shall either party be responsible
for, whether in contract or in tort, any incidental, indirect, special or consequential losses or damages (including lost profits)
arising out of this Agreement or with respect to a party's performance or non- performance of this Agreement. However, the foregoing
limitations of liability and exclusions of damages recoverable in this Section 7.4 shall not (a) apply to breaches of confidentiality
obligations under Section 4, or (b) limit in any way a party's indemnification obligations with respect to third-party claims
under Sections 7.1 or 7.2, as applicable.


 


7.5         Insurance.
Sponsor hereby represents and warrants that it will maintain adequate clinical trial and product liability insurance coverage
for each Project consistent with industry standards, through a reputable insurance carrier, to cover all subjects screened or
treated as part of a clinical trial for personal injury suffered as a result of the participation in the trial or the trial screening
process. PRC represents and warrants that it will maintain an insurance policy or program of self-insurance at commercially reasonable
levels during the term of this Agreement. Each party shall, at the other party's request, provide to the other party proof of
its insurance coverage.


 


		8.	Record Storage; Inspections.



 


8.1         Record
Maintenance During Project. During the term of this Agreement, PRC shall maintain all materials and all other data obtained
or generated by PRC in the course of providing the Services hereunder. including all computerized records and files (collectively,
"Records") . PRC shall cooperate with any reasonable internal review or
audit by Sponsor and make available to Sponsor for examination and duplication, during normal business hours and at mutually agreeable
times, all Records relating to a Project.


 


8.2         Record
Maintenance After Completion or Termination of Project. Unless otherwise stated in the applicable Work Order, all Records
for a Project shall be transferred to Sponsor by PRC upon the Project completion or termination. At Sponsor's option, the Records
shall be either (a) delivered to the location designated by Sponsor at Sponsor's expense, or (b) disposed of at Sponsor's expense.
If PRC is required or requested to maintain and/or store the Records for a Project for a period beyond the completion or termination
of the applicable Project, Sponsor shall reimburse PRC for its reasonable maintenance and storage costs. In no event shall PRC
dispose of Records without first giving Sponsor 60 days' prior written notice of its intent to dispose of the Records and, if
Sponsor so requests, PRC shall transfer such Records to Sponsor at Sponsor's expense. PRC shall be entitled at its sole expense
to retain copies of the Records reasonably necessary for regulatory purposes or to demonstrate the satisfaction of its obligations
hereunder, all subject to the confidentiality obligations set forth in Section 4 above.


 




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	10	version APRIL 2015




     


    

 


8.3         Regulatory
Inspections. If any governmental regulatory authority of appropriate jurisdiction conducts, or gives notice of intent to conduct,
an inspection at PRC directly related to the Services or takes any other regulatory action directly related to the Services, PRC
shall promptly give Sponsor notice thereof and supply to Sponsor all information pertinent thereto. PRC shall cooperate with all
regulatory authorities and permit such inspections relating to the Services. To the extent not prohibited by law, Sponsor shall
have the right, but not the obligation, to be present at any such inspection and to review and comment on any responses required.
If Sponsor receives notice of such an inspection to be conducted at PRC, Sponsor shall inform PRC of said inspection and cooperate
with PRC by providing any information requested by the inspecting authority.


 


8.4         Audits.
Sponsor shall have the right, for the duration of this Agreement and at reasonable times during PRC's normal business hours,
to examine PRC's standard operating procedures, PRC's facilities where Services are performed, and Records to confirm that the
Services are being performed in accordance with this Agreement, the relevant Work Order, the relevant Protocol, and applicable
laws and regulations. PRC shall provide reasonable assistance, including making available members of its staff, to facilitate
such inspections and audits. Sponsor agrees that it shall not disclose to any third party any information ascertained by Sponsor
in connection with any such audit or examination, except to the extent required by law or regulation.


 


8.5         Sponsor
shall reimburse PRC for its time and expenses (including reasonable attorney fees and the costs of responding to findings) associated
with any inspection, audit or investigation relating to the Services instigated by Sponsor or by a governmental authority, unless
such inspection, audit or investigation finds that PRC breached this Agreement or any applicable law or regulation.


 


		9.	Miscellaneous.



 


9.1         Independent
Contractor Relationship. The parties hereto are independent contractors, and nothing contained in this Agreement is intended,
and shall not be construed, to place the parties in the relationship of partners, principal and agent, employer/employee or joint
enture. Neither party shall have any right, power or authority to bind or obligate the other, nor shall either hold itself out
as having such right, power or authority.Any investigators or institutions used in connection with the clinical investigation
to which the Work Order relates shall be independent contractors exercising independent judgment and shall not be deemed to


be employees, subcontractors or agents of
PRC.


 


9.2         Nonsoli
citation. During the term of this Agreement and for 12 months following its termination (the "Restricted Period"),
Sponsor will not, without PRC's prior written consent, directly or indirectly, solicit or encourage any employee or contractor
of PRC to terminate employment with, or cease providing services to, PRC. However, the parties agree that if Sponsor hires an
employee or contractor of PRC in violation of this Section 9.2, Sponsor shall pay PRC a fee of 30% of such person's annualized
salary or contractor rates for the first year of services.


 




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9.3         Force
Majeure. If either party shall be delayed or hindered in or prevented from the performance of any act required hereunder by
reason of strike, lockouts, labor troubles, restrictive governmental or judicial orders or decrees, riots, insurrection, war,
acts of God, inclement weather or other reason or cause reasonably beyond such party's control (each a "Force
Majeure"), then performance of such act shall be excused for the period of such Force Majeure. Any timelines affected
by a Force Majeure shall be extended for a period equal to that of the Force Majeure. The party incurring the Force Majeure shall
provide notice to the other of the commencement and termination of the Force Majeure, and shall take reasonable, diligent efforts
to remove the condition constituting such Force Majeure or to avoid its affects so as to resume performance as soon as practicable.
Notwithstanding the foregoing, this Section 9.3 shall not excuse any delay or failure by Sponsor to pay any amounts owed to PRC
hereunder.


 


9.4         Notices.
Any notice required or permitted to be given hereunder by either party hereto shall be in writing and shall be deemed given on
the date delivered if delivered (a) personally, (b) by recognized overnight courier, (c) via facsimile (with confirmation of receipt
generated by the transmitting machine) or (d) by certified mail, return receipt requested, postage prepaid. All notices to each
party shall be sent to the address for said party set forth in the applicable Work Order. If no address is provided in the Work
Order, then notices shall be sent to the following address:


 


If to Sponsor:


 


	 	 	Correspondence to:	 	Finance/Accounts Payable:
	Sponsor:	 	Creative Medical Health, Inc.	 	Creative Medical Health,
    Inc.
	Contact:	 	Donald Dickerson	 	TimothyWarbington
	Address:	 	2007 W Peoria Ave., Phoenix,	 	2007 W Peoria Ave., Phoenix, AZ
	 	 	AZ. 85029	 	85029
	 	 	 	 	 
	Phone:	 	972-822-9192	 	480-789-9939
	Fax:	 	-	 	 
	Emaii:	 	coo@creativemedicalhealth.con	 	ceo@creativemedi calhealth.con
	 	 	 	 	 
	lf to PRC:	 	 	 	 
	 	 	 	 	 
	Contact:	 	Curtis Head, CEO	 	Tony Taricco, President,
    COO
	Address:	 	1111 Bayhill Dr., Ste 290	 	1111 Bayhill Dr., Ste
    290
	 	 	San Bruno, CA 94066	 	San Bruno, CA 94066
	Phone:	 	877.519.6001
    x 701	 	877.519.6001
    x 702
	Email:	 	chead@prcclinical.com	 	ttaricco@prcclinical .
    com


 


Either party may change its notice address
by notice to the other party hereto in the form and manner provided in this Section 9.4.


 


9.5         Severance.
If any one or more provisions of this Agreement shall be found to be illegal or unenforceable in any respect, the validity, legality
and enforceability of the remaining provisions shall not in any way be affected or impaired thereby, provided the surviving agreement
materially comports with the parties' original intent. The parties shall make a good faith effort to replace any such provision
with a valid and enforceable one such that the objectives contemplated by the parties when entering this Agreement may be realized.


 




    	PRC Clinical MSA/Sponsor
	12	version APRIL 2015




     


    

 


9.6         Waiver.
Waiver or forbearance by either party hereto of any of its rights under this Agreement or applicable law in any one or more instances
must be in writing and signed by the waiving party and shall not be deemed to constitute a waiver or forbearance of any other
right or a further or continuing waiver of such rights.


 


9.7         Amendments;
Assignment. No amendment, change or modification to this Agreement or any Work Order shall be effective unless in writing
and executed by authorized representatives of the parties hereto. This Agreement and any Work Order may not be assigned by either
party without the other party's prior written consent.


 


9.8.         Arbitration
and Equitable Reli ef.


 


A.
Arbitration. Sponsor and PRC agree that any and all controversies, claims or disputes
with anyone (including without limitation, Sponsor and Sponsor's heirs, successors and assigns, PRC and any employee, officer,
director, shareholder or benefit plan of PRC, in its capacity as such or otherwise} arising out of, relating to or resulting from
Sponsor's performance of the Services under this Agreement or the termination of this Agreement, including any breach of this
Agreement, shall be subject to binding arbitration under the Arbitration Rules set forth in California Code of Civil Procedure
Section 1280 through 1294.2, including Section 1283.05 (the "Rules"} and
pursuant to California law. Sponsor AND PRC AGREE TO ARBITRATE, AND THEREBY AGREE TO WAIVE ANY RIGHT TO A TRIAL BY JURY WITH RESPECT
TO, ALL DISPUTES ARISING FROM OR RELATED TO THIS AGREEMENT. Sponsor understands that this Agreement to arbitrate also applies
to any disputes that PRC may have with Sponsor.


 


B.         Procedure.
Sponsor and PRC agree that any arbitration will be administered by the American Arbitration
Association ("AAA"), and that a neutral arbitrator will be selected in a manner consistent with its Commercial
Rules. Sponsor and PRC agree that the arbitrator will have the power to decide any motions brought by any party to the arbitration,
including discovery motions, motions for summary judgment and/or adjudication and motions to dismiss and demurrers, prior to any
arbitration hearing. Sponsor and PRC agree that the arbitrator will issue a written decision on the merits. Sponsor and PRC also
agree that the arbitrator will have the power to award any remedies, including attorneys' fees and costs, available under applicable
law. Sponsor and PRC agree that the arbitrator will administer and conduct any arbitration in a manner consistent with the Rules
and that, to the extent that the AAA's Commercial Rules conflict with the Rules, the Rules will take precedence.


 


C.         Remedy.
Except as provided by the Rules, arbitration will be the sole, exclusive and final remedy for
any dispute between PRC and Sponsor. Accordingly, except as provided for by the Rules, neither PRC nor Sponsor will be permitted
to pursue court action regarding claims that are subject to arbitration. Notwithstanding the foregoing, the arbitrator will not
have the authority to disregard or refuse to enforce any lawful PRC policy, and the arbitrator shall not order or require PRC
to adopt a policy not otherwise required by law which PRC has not adopted.


 


D.         Availability
of Injunctive Relief. The parties shall retain all rights to seek injunctive relief, as provided
under Section 1281.8 of the California Code of Civil Procedure.


 


9.9         Governing
Law. This Agreement shall be governed by and interpreted in accordance with the laws of the State of California, without giving
effect to any choice of law principles that would require the application of the laws of a different slate.


 




    	PRC Clinical MSA/Sponsor
	13	version APRIL 2015




     


    

 


9.10         Counterparts
and Facsimile Signatures. This Agreement, and any subsequent amendment(s), may be executed in counterparts and the counterparts,
together, shall constitute a single agreement. A facsimile transmission of this signed Agreement or a Work Order bearing a signature
on behalf of a party shall be legal and binding on such party.


 


9.11         Entire
Agreement. This Agreement constitutes the entire agreement between the parties and supersedes, as of the Effective Date, all
prior negotiations, representations or agreements, either written or oral, with respect to the subject matter hereof.


 


9.12         Testimony.
Should PRC be obligated to provide testimony or records regarding a Protocol or a drug that is the subject of any Project
in any legal or administrative proceeding, then Sponsor shall reimburse PRC for its reasonable, documented, out-of-pocket costs
therefor, plus an hourly fee for the time spent by its employees or consultants in providing such testimony or records equal to
the internal fully-burdened cost to PRC of such employee or consultant. However, the foregoing shall not apply (a) to litigation
between the parties arising under this Agreement, or (b) to legal or administrative proceedings that result, in whole or in part,
from (i) the negligence, gross negligence or wilful misconduct of PRC or its personnel, or (ii) PRC's breach of its obligations,
representations or warranties hereunder.


 


IN WITNESS WHEREOF, this
Agreement has been executed and delivered by the parties hereto by their duly authorized officers as of the Effective Date.


 


	PROFESSIONAL
    RESEARCH CONSULTING, INC.	 	(SPONSOR]
	0/8/A PRC CLINICAL	 	 	 
	 	 	 	 
	By:	 	 	By:	 
	 	 	 	 	 
	Name:	 	 	Name: 	Donald Dickerson
	 	 	 	 	 
	Title:	 	 	Title:	Chief
    Operating Officer
	 	 	 	 	 
	Date:	 	 	Date:	11/15/2015


 






    	PRC Clinical MSA/Sponsor
	14	version APRIL 2015