EPA's Records Disposition Schedule PEST 361 Scientific Data Reviews HED Records Center - File R192301 - Page 1 of 24 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, DC 20460 

MEMORANDUM 

SUBJECT: 

OFFICE OF PREVENTION, PESTICIDES, AND TOXIC SUBSTANCES 

04111111 

Product chemistry, Environmental Fate and Eco-effects Scoping 

Document for Registration Review of: Ortho-Benzyl-ParaChlorophenol and Sodium and Potassium Salts 

PC Code(s): 062201/ 062202, 062203 DP Barcode(s)/No(s): 383098 

Decision No.: 440814 Reregistration No(s). 

Petition No(s).: NA Regulatory Action: Registration Review 

Risk Assess Type: Product Case No(s).: 2045 

chemistry/environmental fate and 

ecotoxicity 

TXRNo.:NA 

MRID No(s).: 

5C, 6, and 7 

From: 

Thru: 

To: 

Peer Reviewer: 

CAS No(s): 120-32-1/ 35471-49-9/3184-

65-4 

Please see tables 5A,5B, 40 CFR: NA 

A. Najm Shamim, PhD, Chemist f\-- fi,~----,::- Risk assessment & Science Support Brck~h Antimicrobials Division (751OP) , II. 

Nader 

Risk Assessment 

Elkassabany, 

& Science 

PhD, Chief 

Support 

i/fl 

Branch 

~ Antimicrobials Division (7510P) 

Rebecca VonDem-Hagen, CRM for Ortho-Benzyl-Parachlorophenol and Salts 

Registration Review 

Regulatory Management Branch 2 

Antimicrobials Division (751 OP). ~ 

Donna Randall, Senior Scientist ~ 'I" f " 

Risk Assessment & Science Support Branch 

Antimicrobials Division (7510P) 

I 

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EPA's Records Disposition Schedule PEST 361 Scientific Data Reviews HED Records Center - File R192301 - Page 2 of 24 

TABLE OF CONTENTS 

0-Benzyl-p-Chlo ro p hen 0 I an d Salts----------------------------------2 

A]>]>EN»I}(-------------------------------------------------------------- 16 

REGISTRATION REVIEW »OCUMENT 

]>RO»UCT CHEMISTRY, ENVIRONMENTAL FATE AN» 

ECOLOGICAL EFFECTS SUMMARY FOR ORTHO-BENZYL-

]>ARACHLORO]>HENOL 

Important Note on the Chemistry of O-Benzyl-p-Chlorophenol and Sodium and 

]>otassium Salts: 

0]>]> determined that the environmental fate data indicates the two salts (sodium 

and potassium) of orthobenzyl-4-chlorophenol rapidly degrade into the parent form 

in the environment. Therefore, the data supporting the parent also can be used to 

support the potassium and sodium salts ( RE» on Orthobenzyl-para-chlorophenol, 

1995) 

Regulatory History: 

These chemicals, orthobenzyl-4-chlorophenol and its sodium and potassium salts, were 

first registered by EPA in 1948 as disinfectants. The current registration of these 

chemicals include: "disinfectant, bacteriostat, sanitizer, and microbiocides for 

commercial/industrial water cooling systems, metalworking fluids, hard surfaces like 

decks, food preparation, storage and serving areas, non-food areas like rest room 

facilities, medical/veterinary settings. These are used as tuberclulocides, virucides, and 

fungicides on agricultural farm premises, and in mushroom houses and hospital/medical 

institutions" 

Based on the label review, Table 1 below summarizes the use sites and use patterns 

Table 1 

Antimicrobial Uses and Use sites of OrthoBenzyl-Para-Clorophenol 

Use Site Uses 

Indoor food Agricultural/farm premises, /farm structures, buildings, and 

equipment, dairy cattle (lactating/non-lactating or unspecified) * , 

dairy farm milk handling facilities/equipment; eating establishments: 

equipments/utensils (food contact), food handling areas (food 

contact), food serving areas (food contact), food service areas (food 

contact),egg packing plants (commercial)food dispensing 

equipment/vending machines, food marketing/storage/distribution 

equipment/utensils (food contact), food processing plant equipment 

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EPA's Records Disposition Schedule PEST 361 Scientific Data Reviews HED Records Center - File R192301 - Page 3 of 24 

(food contact, food processing plant premises (nonfood contact), 

food/grocery /marketing/storage/ distribution facility premise, 

hog/pig/swine meat, household domestic dwelling indoor food 

handling areas, human drinking water systems, (water related 

surfaces, livestock, meat processing plant equipment, (food contact), 

poultry (egg/meat), poultry (meat), poultry processing plant 

equipment( food contact), poultry processing plant premises 

(nonfood contact), 

*site term to general: could mean: indicate premise treatment, 

animal feeding/watering equipment treatment, equipment treatment 

or transportation vehicle treatment. 

Indoor-N on-food Animal kennels/sleeping quarters (commercial; animals (lab 

research; carpets (commercial sanitizer); commercial transportation 

facilities- nonfood; commercial/institutional/industrial floors; 

commercial/institutional/industrial premises/equipment (indoor); 

eating establishments, food handling areas (nonfood contact; eating 

establishments food serving areas (nonfood contact); egg handling 

equipment (hatching); egg plantslhatcherieslbrooder rooms/shoe 

baths (hatching); egg washing treatment (hatching);horses 

(how/race/special/ponies); laundry (commercial); leather/leather 

products; metalworking fluids (MWF);refuse/solid waste containers 

(garbage cans); rubber products; site term too general; specialized 

animals, textiles/textile fiber/cordage. 

Indoor Medical Baberlbeauty shop instruments )shavers/scissors); carpets (hospital 

santizer); diapers (hospitallaundry);hospital conductive floors; 

hospital critical items( surgical instruments/pacemakers); hospital 

noncritical items (bedpans/furniture); hospital semi critical 

items( catheters/inhalation equipment); hospital/medical institutionsnonconductive floors; hospital/medical institutions critical premises; 

hospital/medical institutions patient premises;;hospital/medical 

institutions premises (human/veterinary); household sickrooms 

premises /contents/utensils; human waste (typhoid 

stools/feces/urine; laundry (hospital); site term too general 

Indoor residential Bathroom premiseslhard surfaces; birds; carpets (household 

saniziters); diaper pails (empty); household/domestic dwellings; 

household/domestic dwellings contents; household/ domestic 

dwellings indoor premises; human grooming instruments (brushes, 

combs); laundry (household/coin-operated); pet living(sleeping 

quarters; refuse /solid waste containers; refuse/solid waste sites 

(indoor); refuse/solid waste transportation facilities/handling 

equipment; residential floors, site too general; toilet bowls (interior 

surfaces);toilet tanks (water closets; urinals (interior surfaces). 

Industrial process Industrial recirculating water systems, industrial cooling towers and 

and water systems evaporative condensers* 

*Sodium salt of orthobenzyl-para-chlorophenol 

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Formulation types registered: TGAI, MUP and EUP 

Formulations forms: Emulsifiable concentrate, soluble concentrate, /liquid; liquidREU; pressurized liquid; solid: forms not identified. 

Table 2 summarizes the types of applications along with the rates of application for 

various indoor, and outdoor sues. 

Table 2 

Type of Applications and Rates of Applications 

Type of Applications Rates f Applications 

Indoor food Disinfectant for hard surfaces: 43-1122 ppm active by vol; 

97-1091 ppm active by wt; 

Food contact surfaces require potable water rinse 

Indoor-nonfood Disinfectant for hard surfaces: 43-2941 ppm active by vol; 

97-2657 ppm active by wt; 

Sanitizer for laundry: 233 ppm active by vol; 102 ppm-278 

ppm active by wt; 

Residential bacteriostatic for odor causing bacteria in 

laundry: 0.3 ppm active by wt; 

Carpet sanitizers: 180 ppm active by vol; 

Fungicide (mold/mildew): 18,000 ppm active by wt. 

Indoor medical Disinfectant for hard surfaces: 202-3820 ppm active by 

vol; 97-3713 ppm active by wt; 

Diaper sanitizer: 102 ppm active by wt; 

Carpet sanitizer: 523 ppm active by vol; 

Sanitary disposal of human waste: 769 ppm active by vol 

Indoor Residential Disinfectant for hard surfaces: 202-2941 ppm active by 

volume; 97-39,400 ppm active by wt; 

Toilet bowls and urinals (interior surfaces): 2.3 -35,000 

ppm active by wt. 

Laundry sanitizer: 105-209 ppm active by vol. 

Aquatic non-food Disinfectant for water-related hard surfaces: 769-1409 ppm 

residential active by vol; 1400 ppm active by wt. 

Terrestrial non-food Disinfectant for refuse/waste waste sites (outdoor): 623 

ppm active by vol. 

Industrial process and Recirculating cooling towers as a microbiocide: 261-521 

water systems ppm 

Table 3 the list of registered active products, product identification, percent of the active 

and the corresponding registrants. 

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Table 3: 

Registered Active Products for Ortho-Benzyl-para-chlorophenol and its Sodium and 

Potassium Salts 

EPA Reg. Product Name % Active Registrant 

Number Ingredient 

211-62 Low pH Phenolic 6.65 Central solutions, Inc 

256 

303-223 Beaucoup Germicidal 5.32 Huntington Professional Product 

Detergent 

303-225 MATAR 10.6 Huntington Professional Products 

675-19 Bulk Amphyl Brand 2.7 Reckitt Benckiser, Inc 

Disinfectant 

675-43 Amhpyl 5.11 Reckitt Benckiser, Inc 

675-LA Lysol Brand 5.5 Reckitt 

Disinfectnat Conc 

(formula # 269-005) 

777-94 Lysol Brand 5.5 Reckitt Benckiser, Inc 

Disinfectant Conc 

954-13 Spacide 4.75 King research, Inc 

1043-19 Staphene Disinfectant 0.077 Steris Corporation 

Spray and Deodorizer 

1043-26 I-Stroke Environ 8.5 Steris Corporation 

1043-118 LPH® 6.4 Steris Corporation 

1677-128 Sani-Glide 1.4 Ecolab, Inc 

2212-17 Legphene 3.8 Walter G. Legge Company, Inc 

2296-102 NAC Pine Odor 3.6 National Chemical Laboratories, Inc 

Disinfectant 

2296-105 Pine- Act 2.0 National Chemical Laboratories, Inc 

2296-106 NAC-Mint Disinfectant 5.2 National Chemical Laboratories, Inc 

3862-177 TEK-Trol Disinfectant 10 ABC Compounding Co., Inc 

Cleaner Conc 

3862-178 TEK-Phene 6.5 ABC Compounding Co., Inc 

3862-179 Opti-Phene cleaner 3.0 ABC Compounding Co., Inc 

Disinfectant Deodorant 

3862-18- PhenO-TEK 5.06 ABC Compounding Co., Inc 

5741-22 Stephene II Brand 0.071 Spartan Chemical Co., Inc 

Disinfectant Deodorant 

6836-252 Phenocide 256 9.5 Lonza Inc 

6836-253 4.75 Lonza Inc 

33176-6 Airsol Brand Multi- 0.08 Amrep, Inc 

Purpose Disinfectant 

Cleaner 

34810-8 Wex-cide Concentrated 5.76 Wexford Labs., Inc 

Germicidal Detergent 

34810-21 Ready to Use Wex-Cide 0.023 Wexford Labs., Inc 

34810-31 Wex-cide 128 3.03 Wexford Labs., Inc 

39967-5 Preventol BP Technical 98.6 LANXESS Corporation 

39967-6 Preventol, BP, 75% in 75.0 LANXESS Corporation 

Isopropanol 

39967-81 Hospital Broad Brand 5.0 LANXESS Corporation 

39967-83 Ocide Hospital Cleaner- 10.10 LANXESS Corporation 

Disinfectant 

46851-1 OMNI-II 1.0 Certol International Products 

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46851-5 OMC II Spray 0.03 Certol International Products 

46851-10 Prospray TM Wipe, 0.03 Certol International Products 

Disinfectant Towletts 

61282-53 Bio-Phene Liquid 9.97 HACCO, Inc 

Disinfectant 

62296-1 Let's Touch 5.25 RBR Productions, Inc 

66171-1 Advantage 256 Cleaner 3.0 Preserve International 

disinfectant deodorant 

70385-7 Clean Carpet Sanitizer 4.9 Prorestore Products 

70627-6 Phenolic Disinfectant 10.5 Diversey, Inc 

HG 

211-25 Pheno CEN Germicidal 8.03 Central solutions, Inc 

Detergent' 

4313-41 Pine II Pine Odor 

Disinfectant ' 

2.4 Carroll Company 

74655-24 WRICOBGN 23.5 Hercules Incorporated 

211-36 TRI-CEN2 4.4 Central solutions, Inc 

1769-374 Ancocide 40102 19.85 NCH Corporation 

3862-11 Pine Odor Disinfectanf 5.1 ABC Coml'ounding Co., Inc 

3862-136 Vita-Pine (Coeff5)2 3.93 ABC Compounding Co., Inc 

34810-16 Phenex-CELL 7.15 Wexford Labs., Inc 

1. Potassium Salt of orthobenzyl-para-chlorophenol 

2. Sodium Salt of orthobenzyl-para-chlorophenol 

Table 4A. Chemical Identity 

Common Name Ortho-Benzyl-para-Chlorophenol 

._-

Chemical Name Ortho-Benzyl-para-chlorophenol 

(also 2-Benzyl-4-chhlorophenol) ._-

IUPACName Ortho-Benzyl-para-chlorophenol -- Molecular Weight 218.5 ._- PC Code 062201 

._-

CAS Registry Number 120-32-1 .-- Molecular FormulalEmpirical C13HllCIO 

Formula ._- Registration Review Case No. 2045 .--

Registration Review Case Name Ortho-Benzyl-para-chlorophenol 

._-

Classification: Organic .-

Structure: 

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HO 

Table 4B.· Cleiaiealldentity 

Common Name 2-Benzyl-4-chlorophenate, sodium salt 

._-

Chemical Name Ortho-Benzyl-para-chlorophenate, sodium salt 

._-

IUPACName Ortho-Benzyl-para-chlorophenate, sodium salt ._- Molecular Weight 240.5 

._-

PC Code 0662202 

._-

CAS Registry Number 3184-65-4 

._-

Molecular Formula/Empirical C13HIOCIONa 

Formula 

._-

Registration Review Case No. 2045 

._-

Registration Review Case Name 2-Benzyl-4-chlorophenate, sodium salt 

._-

Classification: Organic ._-

Tabte4C.C.hemi~l4entity 

Common Name 2-Benzyl-4-chlorophenate, potassium salt .--

Chemical Name Ortho-Benzyl-para-chlorophenate, potassium salt 

._-

IUPACName Ortho-Benzyl-para-chlorophenate, potassium salt .--

Molecular Weight 236.5 

._-

PC Code 0662203 

._-

CAS Registry Number 35471-49-9 

._-

Molecular Formula/Empirical CI3HIOCIOK 

Formula ._-

Registration Review Case No. 2045 .--

Registration Review Case Name 2-Benzyl-4-chlorophenate, potassium salt ._- Classification: Organic 

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Science Findings: 

Following tables summarize the science data for each discipline, and lists some possible 

data gaps. 

Product Chemistry Summary 

T a e bl SA : Ph lYSlca . I d an Ch emlca IP ropertles 0 fO rt h B 0- enzyl-para-c I hi orop h eno I 

Guideline Physical and Chemical Properties Value 

No. 

830.1550 Product identity and composition Refer to Table 2A1 MRlD# 470262-05 

830.1600 Description of materials used to CBV MRlD#: 470262-05 

produce the product 

830.1620 Description of production process CBII MRlD#:470262-02 

830.1650 Description of formulation process CBV MRlD#470262-05 

830.1670 Discussion of formation of impurities CBII MRlD#:470262-05 

830.1700 Preliminary analysis CBII MRlD#:470262-05 

830.1750 Certified limits CBII MRlD#470262-05 

830.1800 Enforcement analytical method CBII MRlD#;470262-05 

830.1900 Submittal of samples CBI 

830.6302 Color White to light gray: MRlD# 470953-01 

830.6303 Physical State solid; MRlD#: 4709353-01 

830.6304 Odor Slightly phenolic: MRlD#: 470953-01 

830.6313 Stability to sunlight, normal and 

elevated temperature 

830.6314 OxidationlReduction: Chemical MRlD#:470262-05 

Incompatibility 

830.6315 Flammability MRlD#:470262-05 

Flash Point 

830.6316 Explodability MRlD#:470262-05 

830.6317 Storage Stability No observed difference in the material at the start 

and after 30 days (Interim report for 30-day study); 

MRlD#:4 70953-01 

830.6319 Miscibility MRlD#:470262-05 

830.6320 Corrosion Characteristic MRlD#:4 70953-01 

830.6321 Dielectric breakdown voltage MRlD#: 470262-05 

830.7000 pH 5.3 (saturated aqueous solution) MRlD#:470262-

05 

830.7050 UVNisible absorption spectra 

830.7100 Viscosity MRlD#: 470262-05 

830.7200 Melting Point 49°C 

830.7220 Boiling point 175 ° C 

830.7300 Densityl Bulk density 0.49 g/cm3 /30.5 lbs/ft3 MRlD#: 470967-02 

830.7370 Dissociation Constants in water 10.8 + 0.2 at 20 ° C 

830.7520 Particle size NA 

830.7550 OctanoVwater partition coefficient Log Kow= 4.3 

(Kow) (Log Kow ) 

830.7840 Solubility in water 0.007 g/100g 

830-7840 Solubility in organic solvents in gil 00 Methyl ethyl ketone: 656 

ml Isopropyl alcohol: 601 

Ethyl alcohol: 422 

Benzene: 219 

Carbon tetrachloride: 92 

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Guideline Physical and Chemical Properties Value 

No. 

Mineral oil: 2.3 

830.7950 Vapor pressure 0.075 mm Hg at 100 °c 

Note: CBI: ConfidentIal Busmess InformatIOn 

Table 5B: Physical and Chemical Properties of Orthobenzyl-parachloro-phenol, 

sodium salt 

Guideline Physical and Chemical Properties Value 

No. 

830.1550 Product identity and composition Refer to Table 2a 

830.1600 Description of materials used to CBI 

produce the product 

830.1620 Description of production process CBI 

830.1650 Description of formulation process CBI 

830.1670 Discussion of formation of impurities CBI 

830.1700 Preliminary analysis CBI 

830.1750 Certified limits CBI 

830.1800 Enforcement analytical method CBI 

830.1900 Submittal of samples CBI 

830.6302 Color Grayish white: MRID:46052702 

830.6303 Physical State solid; MRID 46052702 

830.6304 Odor Odorless: MRID: 46052702 

830.6313 Stability to sunlight, normal and Not reported 

elevated temperature 

830.6314 OxidationlReduction: Chemical Not reported; MRID# 46052702 

Incompatibility 

830.6315 Flammability NA: MRID# 46052702 

Flash Point 

830.6316 Explodability NA: MRID#: 46052702 

830.6317 Storage Stability MRID#: 46052702 

830.6319 Miscibility Not reported; MRID: 46052702 

830.6320 Corrosion Characteristic Not corrosive; MRID#: 46052702 

830.6321 Dielectric breakdown voltage NA 

830.7000 pH 12.5 ; MRID#: 46052702 

830.7050 UV Nisible absorption spectra MRID#: 45266603 

830.7100 Viscosity Not <lllplicable 

830.7200 Melting Point No Report 

830.7220 Boiling point No Report 

830.7300 Density/ Bulk density 3.2-3.34 glcc MRID#: 56052702 

830.7370 Dissociation Constants in water Not applicable 

830.7520 Particle size No Report 

830.7550 Octanollwater partition coefficient Not applicable for salt forms as the salt degrades 

(Kow) (Log Kow ) into the parent form 

830.7840 Solubility in water 1730 gIL at 20 0 C; 0.185 glI00 ml at 0 0 C; 0.077 

g/100 ml at 100 ° C; MRID#: 46052702 

830-7840 Solubility in organic solvents in g/lOO No Report 

ml 

830.7950 Vapor pressure It is a solid, vapor pressure is likely negligible 

CBI: Confidential Business Information 

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Table 5C: Physical and Chemical Properties of Orthobenzyl-parachloro-phenol, 

potassium salt (as a 23.5% aqueous solution ofthe salt). Some of the P/chem. 

properties reported in the following table are those of the parent molecule: 

orthobenzyl-papra-chlorophenol) 

Guideline Physical and Chemical Properties Value 

No. 

830.1550 Product identity and composition Refer to Table 2a 

830.1600 Description of materials used to CBI 

produce the product 

830.1620 Description of production process CBr 

830.1650 Description of formulation process CBI 

830.1670 Discussion of formation of impurities CBI 

830.1700 Preliminary analysis CBI 

830.1750 Certified limits CBI 

830.1800 Enforcement analytical method CBI 

830.1900 Submittal of samples CBI 

830.6302 Color Yellow to Brown: MRlD:447836-01 

830.6303 Physical State Clear liquid; MRlD 447836-01 

830.6304 Odor Very faint, phenolic: MRlD: 447836-01 

830.6313 Stability to sunlight, normal and Not reported 

elevated temperature 

830.6314 OxidationlReduction: Chemical Formulation does not exhibit any oxidationIncompatibility reduction action when exposed to metals present in 

the water systems such as stainless steel, copper, 

and mild steel at use concentrations; MRlD# 

447836-01 

830.6315 Flammability NA: MRlD# 447836-01 

Flash Point 

830.6316 Explodabil~ NA: MRlD#: 447836-01 

830.6317 Storage Stability No change in the concentration of the active 

ingredients when stored for one year under 

ambient warehouse conditions in commercial 

packaging material composed of high density 

polyethylene MRlD#:447836-01 

830.6319 Miscibility NA; MRlD: 447836-01 

830.6320 Corrosion Characteristic No evidence of corrosion on the container by the 

formulation for one year under ambient conditions; 

no effect seen on the packaging materials like PE, 

PVC, PP, PTFE etc.: MRID#: 447836-01 

830.6321 Dielectric breakdown voltage NA; the product is not to be used around electrical 

equipment; MRID#: 447836-01 

830.7000 pH (1 % solution) 11-13; MRID#:447836-01 

830.7050 UVNisible absorption spectra MRlD#: 447836-01 

830.7100 Viscosity 21 cps: MRlD#: 447836-01 

830.7200 Melting Point 45 0 C (for the Orthobenzyl-para-chlorophenol 

component): MRlD# 447836-01 

830.7220 Boiling point NA 

830.7300 Density/ Bulk density 9.450 bls/gallon at 20° C; 1.12-1.15 glcc; 

MRlD#: 447836-01 

830.7370 Dissociation Constants in water Not applicable 

830.7520 Particle size No Report 

830.7550 Octanol/water partition coefficient; Not applicable fro salt form, as the salt dissociates 

(Log Kow) into the parent for m. It is 4.4 for the orthobenzyl10 
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Guideline Physical and Chemical Properties Value 

No. 

para-phenol component; MRID#; 447836-01 

830.7840 Solubility in water Highly water soluble; MRID#: 447836-01 

830-7840 Solubility in organic solvents in g/100 No Report 

ml 

830.7950 Vapor pressure 17.5 mm Hg (for the orthobenzyl-parachlorophenol component); MRID#: 447836-01 

CBI: Confidential Business Information 

Environmental Fate and Transport Data Summary: 

The following environmental fate and transport data are present in the Agency database. 

The data is summarized in the table below: 

Table 6 

Environmental Fate and Transport Summary 

Guideline Study Reference Results/Conclusions 

No./Study Type 

835.4100 MRID 00086320: Degradation pathway is through 

Aerobic Soil Uniroyal Chemical adsorption by the parent molecule and 

Metabolism (1977); soil persistence the degrades into organic soil fraction. 

study (sandy loam soil) 

8% of the product degraded into 

unidentified product( s) after eight 

months. 

Half life of the product at 25 0 C was 

480 days. 

Conclusions: The product is persistent in 

sandy loam soil under aerobic conditions 

Anaerobic Aquatic MRID 00125971 The product was found degradable in: 1) 

Metabolism R. Swisher, W. Gledhill, unacclimated river water (0.1 mg/L, 

1973: Biodegradation of degraded completely in six days); 2) 

o-benzyl-para- acclimated activated sludge (1.0 mg/L, 

chlorophenol: Applied degraded 80% in 8 hours); and 100% in 

Microbiology, 26(3); pp 24 hours; 3) effluent from semi394-398 continuous activated sludge ca 60% of 

the CO2 was from the product; 4) 

sewage(0.5 and 1.0 mg/L degraded in 

one day 

Conclusions: the product appears readily 

biodegradable under anaerobic 

conditions 

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Environmental Fate and Transport Data Gaps 

The Agency has not conducted environmental fate risk assessment. For a complete risk 

assessment for these chemicals, based on the use sites/ use patterns, the Agency 

anticipates to require the following environmental fate and transport data: 

835.2120 Hydrolysis 

835.2240 Photodegradation in water 

835.1110 Activated sludge, Respiration Inhibition Test 

Ecological Effects Data Summary: 

Table 7 summarizes the eco-toxicity data of orthobenzyl-para-chloro-phenol and salts 

Guideline #/Study 

type 

850.1010: 

Acute Toxicity to 

Freshwater 

Invertebrates 

850.1075 

Acute Toxicity to 

Fresh water fish 

850.1075 

Acute Toxicity to 

Fresh water fish 

850.2100 

Avian Acute Oral 

Toxicity 

Table 7 

Ecotoxicity Data 

MRID#lReference Dosing/Organism 

Comments/Study Information 

Classification 

MRID#: Concentrations: 2, 

133336/92008007 1.2,0.75,0.43,0.26 

Toxicity of or 0.16 mg/l000 ml. 

Nipacide BCP to 15 Daphnia magna 

Daphnia magna 100% purity 

No classification 

made 

MRID#: 00133334: Static Bioassay; 

Toxicity of Concentrations: 5, 

Nipacide to Bluegill 2, 1.2,0.72,0.43" 

0.62 ppm 

Core Percent purity: 95% 

MRID#: 00133335: Static Bioassay; 

Toxicity of Concentrations: 2, 

Nipacide to 1.2,0.72,0.43,0.26 

Rainbow trout ppm a.i. 

Core Percent purity: 95% 

MRID#: 00138112; Single oral dose 

Toxicity of exposure study: 

Nipacide to Bob Concentrations: 

white 398,631,1000, 

Core 1590, 2510 mglkgbw 

Results 

24 hour LC50: 1.3 

mglL 

48 hour LC50: 0.59 

mg/L 

No discernable 

effect concentration 

through 48 hours: o. 

16 mglL 

Highly toxic 

96 hour LCso: 0.33 

ppm 

Highly toxic 

96 hour LC50: 0.72 

ppm 

Highly Toxic 

LD 50: > 2510 

mg/kg 

Practically nontoxic 

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Percent purity: 95% 

8502200: Avian MRID#: 00138888; Dietary: LCso> 5620 ppm 

Acute Dietary Toxicity of Concentrations: 

Toxicity Nipacide to Mallard 562, 1000, 1780, Practically nonDuck 3160, 5620 ppm- toxic 

Core diet 

850.2200: Avian MRID#: 00138887; Dietary: LCso > 5620 ppm 

Acute Dietary Toxicity of Concentrations: 

Toxicity Nipacide to 562, 1000, 1780, Practically nonBobwhite 3160, 5620 ppm- toxic 

Core diet 

Notes on Table 7: 

1. The study review of 850.1010 (acute toxicity of freshwater invertebrate) did not 

establish the classification of the study (core or supplemental, or invalid). Therefore 

this study is being regarded as a data gap, and the Agency is including it in the gaps 

for the ecological data requirements. 

2. These studies were conducted by independent labs, under individual labs SOPs before 

the Agency test Guideline Series 850 were instituted. The reviews of these studies 

were also carried before the establishment of the 850 Test Guidelines. The Agency has 

not revisited these studies and reviewed again in the light of the established Test 

Guideline (Series 850) since then. At the time of reregistration and the risk 

assessment process of these pesticides, the Agency will review these studies again 

based on the 850 Test Guidelines, and if found deficient may classify them as 

supplemental. If these studies are classified as supplemental, the effect of any 

uncertainties introduced in the assessment will be discussed. 

3. Acute oral toxicity (rat) and two year rat reproduction study results for 

mammalian toxicity values are summarized below: 

870.1100 

Acute Oral Toxicity (Rat) Toxicity Category III LDso = 4462/3852 mg/kg (M/F) 

870.3800 

Reproduction and Fertility Effects Toxicity category missing, no end points established 

4. The acute toxicity and two-generation mammalian toxicity (reproduction and fertility 

effects) on terrestrial and aquatic animals will also be included in the ecological risk 

assessment 

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EPA's Records Disposition Schedule PEST 361 Scientific Data Reviews HED Records Center - File R192301 - Page 14 of 24 

Table 8 

Ecotoxicty Categories 

Birds and Mammals Category Aquatic animals 

LDso(mg/kg) LCso(ppm) LCso (ppm); ECso(ppm) 

<10 < 50 Very highly toxic < 0.1 

10-50 50-500 Highly toxic 0.1-1 

51-500 501-1000 Moderately toxic > 1-10 

501-2000 1001-5000 Slightly toxic > 10-100 

>2000 >5000 Practically non-toxic > 100 

Ecotoxicity Data Gaps: 

850.1 010 Acute Toxicity to Freshwater Invertebrates 

850.1025 or 850.1055: Mollusc shell Deposition or Embryo/Larval Toxicity 

850.1035 Mysid Acute Toxicity 

850.1300 Freshwater Invertebrate Life-Cycle 

850.1400 Fish Early-Life-Cycle 

850.5400 Aquatic growth, green algae 

850.1710] Aquatic organisms, bioavailability, biomagnifications toxicity tests 

850.1730] for all three tests 

Environmental Fate and Transport and Ecological Effects Conclusions: 

Orthobenzyl-para-chlorophenol is persistent under aerobic conditions in sandy loam soils 

with a halflife of greater than one year. The parent has a very high Log Kow value (4.4), 

and therefore it has the potential to bioaccumulate. 

Orthobenzyl-para-chlorophenol is highly toxic to freshwater invertebrates, Rainbow trout 

and Bluegill, and practically non-toxic (orally, and dietary) to Bobwhite and Mallard. 

AD has reviewed the previous fate and effects risk assessment in the 1995 Reregistration 

Eligibility Decision (RED) document of orthophenol-para-chlorophenol and its sodium 

and potassium salts. No quantitative ecological risk assessments were performed at that 

time because pool uses were considered to result in minimal to no exposure based on 

infrequent draining of pools and all other uses would be dealt with National Pollution 

Discharge Elimination System (NPDES) permitting of the Office of Water. Based on the 

change in data requirements, evolution of the Agency science and regulatory policies, and 

development of many exposure models which are now used for risk assessments, 

it is anticipated that these assessments need to be updated. 

Endangered Species Determination: 

The Agency has not conducted an ecological risk assessment that supports a complete 

endangered species effects determination for orthobenzyl-para-chlorophenol and salts. 

The ecological risk assessment planned during the registration review will allow the 

Agency to determine whether THPS' s use has "no effect" or "may affect" federally listed 

threatened or endangered species (listed species) or their designed critical habitats. When 

effects determination concludes that a pesticide's use "may affect" a listed species or its 

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EPA's Records Disposition Schedule PEST 361 Scientific Data Reviews HED Records Center - File R192301 - Page 15 of 24 

designated critical habitat, the Agency will consult with the US Fish and Wildlife Service 

and/or National Marine Fisheries Services as appropriate 

Water Quality 

Orthobenzyl-para-chlorophenol and its sodium and potassium salts are not identified as a 

cause of impairment for any water bodies listed as impaired under section 303(d) of the 

Clean Water Act, based on information provided at the Agency's NationalPesticides 

Cause ofImpairment of Water website (searched Apri111, 2011)1. In addition, no Total 

Maximum Daily Loads (TMDL) has been developed for orthobenzyl-para-chlorophenol 

and its sodium and potassium salts, based on information provided at the Agency's 

National Pesticides TMDL website (searched April 11. 2011i More information on 

impaired water bodies and TMDLs can be found at http://www.epa.gov/owow/tmdll. 

The Agency invites submission of water quality data for this pesticide. To the extent 

possible, data should conform to the quality standards in Appendix A ofthe OPP 

Standard Operating Procedure: Inclusion of Impaired Water Body and Other Water 

Quality Data in OPP's Registration Review Risk Assessment and Management Process 

(see: http://www .epa. gov I oppfead 11 c b/ppdc/2006/november061 session I-sop. pdf), in 

order to ensure they can be used quantitatively or qualitatively in pesticide risk 

assessments. 

l:http://iaspub.epa.gov/tmdl_waterslO/attains_nation_cy.cause_detaiC303?p_cause_grou 

p_id=885 

2:http://iaspub_epa.goc/tmdl_waters10/attains _ nation.tmdlJ>ollutant_ detail?p J>ollutant_ 

group _id=885&p J>ollutant_group _ name=PESTICIDES 

Incidence Reports on Aquatic, Terrestrial, Avian Organisms. 

There are no reported incidences in the Agency's Ecological Incidence Information 

System (EllS) regarding orthobenzyl-para chlorophenol (searched Apri112, 2011); 

database last updated 101. The absence of documented incidents does not necessarily 

mean that such incidences did not occur. 

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APPENDIX A 

Data Justifications for Ecotoxicity and Environmental Fate and Transport of 

Orthobenzyl-Para-Chloro-Phenol (OBCP) I and Sodium and Potassium Salts. 

The data justifications is for the parent (orthobenxyl-para-chlorophenol) only. 

OBCP stands for: Orthobenzyl-para-chlorphenol 

Guideline Number: 850.5400 

Study Title: Al2al toxicity 

...i;"· >t\"·· ~ for Requiring the Data 

As part of a Tier I risk assessment, one indicator plant species is tested for phytotoxicity. This study 

would allow the Agency to categorize OBCP and its salts as toxic or non-toxic to plants. If toxic, 

additional higher tier plant tests would be needed. An endangered species assessment for endangered or 

threatened plants is not possible without this study. 

Practical Utility of the Data 

1. How will the data be used? 

This study would be used to evaluate the toxicity of OBCP and its salts to non-target plants in 

terrestrial and aquatic ecosystems. 

2. How could the data impact the Agency's future decision-making? 

Adverse effects to non-target plants in terrestrial and aquatic ecosystems may result in mitigation to 

protect species at risk. Mitigation might include reduced label dosages, neutralization of effluents prior 

to discharge into water, restrictions on use in sensitive ecosystems or where endangered species are 

present, or other mitigation measures. 

3. What is triggering the need for this data? 

Increased concern from state regulators and the public to evaluate impacts on WWTP operations, 

endangered species, and persistence in the environment, since initial registration, have triggered the need 

for this study. Green algae are critical to ecosystem health and productivity. 

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._-

Guideline Number: 835.1110 

Study Title: Activated Sludge Sorption Isotherm 

Rationale for ReQuirine; the Data 

The results from activated sludge sorption study would allow EPA to assess the distribution of the 

antimicrobial among the solid, aqueous, and vapor phases ofWWTPs. Specifically, this study identifies 

those chemicals which sorb to sludge biomass. 

PractiealUtility of the Data 

1. How will the data be used? 

The data would be used to determine the sorption potential of OBCP and its salts to activated sludge 

biomass and in biological wastewater treatment systems. 

2. How could the data impact the Agency's future decision-making? 

If OBCP and its salts is not sorbed or biodegraded then, it would pass through a biological treatment 

system unaffected and it may contaminate surface and drinking waters and also may have potential 

adverse effects to nontarget organisms. 

3. What is triggering the need for this data? 

Studies are needed to conduct environmental fate assessment and to determine the sorption potential of 

activated sludge for the removal of specific chemical compounds in biological wastewater treatment 

systems. ._-

~~~~~~~--~~~~------------------------------------------------------.-- Guideline Number: 835.2120 

Study Title: Hydrolysis 

Rationale for Requirine; the Data ~--~--~----------~----~~~==~~~~~~~~~~-------------------------- Results from the hydrolysis study will indicate the stability and persistence of OBCP 

and its salts, indicating the potential for this chemical to contaminate water discharged to 

WWTPs. In aquatic effluents, WWTPs may discharge directly to surface waters. The 

Agenc)' will evaluate.IJotential risks of concern. r-~~~--------~------------------------------------------------------------.. --- Practical Utility of the Data ~--------------------------~~~~~~~~~~~~--------------------------.--

1. How will the data be used? 

Data would showlhelp in establishing chemical hydrolysis as a route for degradation of a pesticide and 

to identify, if possible, the hydrolytic products formed which may adversely affect non-target organisms 

and may contaminate water and food source of aquatic organisms. 

2. How could the data impact the Agency's future decision-making? 

The results of hydrolysis data would indicate if OBCP and its salts is persistent or it degrades into 

degradation products which may adversely affect non-target organisms and may contaminate their food 

and water and possibly soil. 

3. What is triggering the need for this data? 

Hydrolysis data is needed to conduct the fate assessment to support indoor uses for OBCP. ~~--~----------------------------------------~-------------------------------

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EPA's Records Disposition Schedule PEST 361 Scientific Data Reviews HED Records Center - File R192301 - Page 18 of 24 

._- Guideline Number: 835.2240 

Data Requirement: Photode2radation in water . Rationale for Requiring the Data 

Biocides introduced into aqueous systems in the environment can undergo photolytic transformation 

by sunlight. Results from the photolysis study will indicate the stability and persistence of OBCP 

and its salts and potential degradates in an aquatic environment when exposed to sunlight. For 

outdoor wood preservative uses, OBCP and its salts can reach surface water through direct contact 

or discharge to WWTPs. OBCP and its salts may also reach surface water or groundwater through 

run-off or leaching processes. The Agency will evaluate the potential risks of concern. -- ..... .( Practical Utility of the Data 

1. How will the data be used? 

The data would establish the significance of chemical photolysis as a route for degradation and 

identify, if possible, the photolytic degradation products formed that may adversely affect non-target 

organisms and may contaminate water and food source of aquatic organisms. The data would also 

help establish the photolytic halflife ofOBCP and its salts and possibly degradates, and assist in developing a degradation pathway. 

2. How could the data affect the risk assessment? 

The results of photolysis data would indicate if OBPC and its salts is persistent or if it degrades into 

degradation products that may adversely affect non-target organisms and may contaminate their 

food. The results of the photolysis data would expand the understanding of the results of the 

hydrolysis data since environmental aquatic conditions usually involve exposure to sunlight. 

3. What is triggering the need for this data? 

Aqueous photo-degradation data is needed to conduct the fate assessment to support indoor and 

outdoor wood preservative uses for OBCP and its salts. ._-

Guideline Number: 850.1010 

Study Title: Acute Aquatic Invertebrate 

Rationale for Requiring the Data 

This study will allow the Agency to determine the toxicity of OBCP to freshwater daphnids. An 

endangered species assessment for endangered or threatened freshwater daphnids is not possible 

without this study. Therefore, this study is required. 

Practical Utility of the Data 

1. How did the Agency make its re-registration decision without this data? 

The Agency imposed risk mitigation through labeling changes as an interim measure. 

2. How will the data be used? 

The study will be used for hazard labeling in the event a spill of manufacturing use product occurs. 

This study will be used to generate a freshwater invertebrate endpoint so that the Agency can evaluate 

the toxicity of OBCP to non-target and endangered/threatened freshwater daphnids in freshwater 

aquatic ecosystems. 

3. How could the data impact the Agency's future decision-making? 

If the acute freshwater fish toxicity is 1.0 mgIL or less, the label must state: "This pesticide is toxic to 

fish." A freshwater fish endpoint will allow the Agency to determine if endangered or threatened 

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EPA's Records Disposition Schedule PEST 361 Scientific Data Reviews HED Records Center - File R192301 - Page 19 of 24 

species are at risk or if freshwater fish are impacted after residues pass through waste water treatment 

plants into surface waters. Mitigation might include reduced label dosages, neutralization of effluents 

prior to discharge into water, restrictions on use in sensitive ecosystems or where endangered species 

are present, or other mitigation measures which require refined scientific assessments. 

Guideline Number: 850.1300 

Data Requirement: Aquatic invertebrate chronic NOAEC using Daphnia magna 

.. Rationale for Requiring the Data 

Invertebrates serve as food for fish, birds, crustaceans, and even whales. The protection of nontarget invertebrates is essential to the food chain in any healthy ecosystem. The value in the Daphnid 

(850.1300) chronic toxicity tests are that they provide information on the effects of pesticides on 

mortality, growth, and reproduction over a longer term (21 days for Daphnids compared to acute 

studies. Data are obtained from the first generation (G 1) and the second generation (G2), thus 

allowing examination of the complete invertebrate life cycle for toxicity. 

Practical Utility of the Data 

1. How will the data be used? 

Data would be used to calculate LC50's for mortality, EC50's for growth, a NOEC, and a MATC 

(maximum acceptable toxicant concentration). The data would allow the Agency to determine 

chronic effects, including effects on reproductive success and growth, to freshwater invertebrates 

from water column exposure to OBCP and its salts. 

2. How could the data affect the risk assessment? 

Because acute toxicity data alone are not a reliable indicator of chronic toxicity, chronic toxicity 

data are also required. The Agency cannot make the assumption that a chemical is not chronically 

toxic at much lower concentrations than some ratio of the LC50 value would suggest. The results 

would be used to determine the likelihood that the chronic risks can potentially impact aquatic 

communities, either by direct effects on invertebrates or by indirect effects on organisms which 

feed on them. Daphnia magna (for fresh water) are used to represent all invertebrate species living 

in the water column in the risk assessment process. Additionally, the use of the most sensitive 

species ensures the protection of other species within that taxon. As part of the chronic risk 

assessment for aquatic animals, the lowest NOEC for estuarine/marine invertebrates is used in the 

RQ equation. A chronic LOC is defined by an RQ > 1, and would indicate that there is the potential 

for chronic risk that may warrant regulatory action and that endangered species may potentially be 

affected through chronic exposure. 

3. What is triggering the need for this data? 

Data are needed in order to conduct an ecological risk assessment for the proposed use of OBCP and 

its salts as a wood preservative and determine the chronic toxicity of OBCP to freshwater and marine 

L-invertebrates ____________ using ~ ____ life-cycle L_ ________________________________________________________ studies. .. ___ 

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--- Guideline Number: 850.1400 

Data Requirement: Fish early-life sta2e toxicity test (freshwater) 

... Rationale for Requiring the Data 

Fish early-life stage study is less expensive to conduct than the full life cycle study. Fish early-life 

stage study gives us some indications if the pesticide is toxic to fish reproduction and survival. In 

the fish early-life stage study, fertilized eggs are placed in test chambers and exposed to the 

pesticide in water at least until all the control fish are free-feeding. Lethal and sub lethal effects are 

assessed and compared with control values to determine the LOEC and the NOEC. -- Practical Utility of the Data 

1. How will the data be used? 

The data are used to determine embryo hatch rate, time to hatch, time to swim-up, growth (length and 

weight), and any clinical or pathology findings 

2. How could the data affect the risk assessment? 

As part of the chronic risk assessment for aquatic animals, the lowest NOEC for estuarine/marine 

fish is used in the RQ equation. A chronic LOC is defined by an RQ > 1, and would indicate that 

there is the potential for chronic risk that may warrant regulatory action and that endangered specit:s 

may potentially be affected through chronic exposure. 

3. What is triggering the need for this data? 

Data are needed in order to conduct an ecological risk assessment for the proposed use of OBCP and 

determine the effects of OBCP and its salts on fish develoQment and survival during early life stages. ---

Guideline Number: 850.1025 

Data Requirement: Acute oyster toxicity test (shell deposition) 

Rationale for Requirin2 the Data 

Oysters are important economic species to the United States economy. This acute toxicity test 

measures shell deposition in Eastern oysters (Crassostrea virginica) across a range of concentrations 

to determine if growth is inhibited by short-term (96-h) exposure to OBCP in estuarine/marine 

waters. 

Practical Utility of the Data 

1. How would the data be used? 

Data would be used to characterize the concentration-response curve and determine the NOEC (no 

observable effect concentration) and an ECSO with 9S% confidence interval. The ECSO is the 

concentration of the pesticide in water that is calculated to reduce growth (as measured by shell 

deposition) by SO% compared to the controls. 

2. How could the data affect the risk assessment? 

There are many mussel species that are listed as threatened and endangered in the United States. 

Crassostrea virginica is considered as a surrogate species to represent all estuarine/marine 

invertebrates in the risk assessment process. As part of the acute risk assessment of aquatic animals" 

the lowest ECSO or LCSO for estuarine/marine invertebrates are used as inputs to the Risk Quotient 

(RQ) method for expressing risk. An acute RQ > O.S would indicate an acute level of concern 

(LOC), defined as the potential for acute risk to non-target organisms which may warrant regulatory 

action in addition to restricted use classification. An acute RQ > 0.1 would result in an acute 

restricted use LOC, defined as the potential for acute risk to non-target organisms, which may be 

mitigated through restricted use classification. An acute RQ > O.OS would fall under the LOC for 

acute endangered species. 

3. What is triggering the need for this data? 

Data are needed in order to conduct an ecological risk assessment for the proposed use of OBCP as 

a wood preservative and determine the effects of OBCP on shell deposition in Eastern oysters. 

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EPA's Records Disposition Schedule PEST 361 Scientific Data Reviews HED Records Center - File R192301 - Page 21 of 24 

Guideline Number: 850.1035 

Data Requirement: Acute Mysid toxicity test 

Guideline Number: 850.1045 

Data Requirement: Acute Penaeid toxicity test 

••• Rationale for Requiring the Data 

Shrimp are important economic species to the United States as are lobsters, crabs, and other 

crustaceans. Shrimp are used as surrogate for all other crustaceans. These acute toxicity tests 

measure mortality of estuarine/marine shrimp species, including mysids (OPPTS 850-lO35) and 

penaeids (OPPTS 850-1045) across a range of concentrations to determine if survival is inhibited by 

short-term (96-h) exposure to OBCP in estuarine/marine waters. 

Practical Utility of the Data 

1. How would the data be used? 

Data would be used to describe the concentration-response curves and determine 48- and 96-h 

LC50's (concentrations calculated to kill 50% of the population) along with 95% confidence 

intervals. 

2. How could the data affect the risk assessment? 

Mysidopsis Bahia is considered as a surrogate species to represent all estuarine/marine invertebrates 

in the risk assessment process. As part of the acute risk assessment for aquatic animals, the lowest 

EC50 or LC50 for estuarine/marine invertebrates is used in the RQ method for expressing risk. An 

acute RQ > 0.5 would indicate an acute LOC, defined as the potential for acute risk to non-target 

aquatic organisms which may warrant regulatory action in addition to restricted use classification. 

An acute RQ > 0.1 would result in an acute restricted use LOC, defined as the potential for acute risk 

to non-target organisms, which may be mitigated through restricted use classification. An acute RQ 

> 0.05 would fall under the LOC for acute endangered species. 

3. What is triggering the need for this data? 

Data are needed in order to conduct an ecological risk assessment for the proposed use of OBCP as 

a wood preservative and determine the acute toxicity of OBCP to estuarine/marine shrimp. ._-

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EPA's Records Disposition Schedule PEST 361 Scientific Data Reviews HED Records Center - File R192301 - Page 22 of 24 

._-

Guideline Number: 850.1055 

Data Requirement: Acute oyster embryo larval 

Rationale for Requiring tbe Data 

Oysters are an important economic species to the United States as are lobsters, crabs, and other 

crustaceans. The bivalve acute toxicity test measures mortality and abnormal development in 

Eastern oysters (Crassostrea virginica) , Pacific oysters (Crassostrea gigas), quahogs 

(Mercenaria mercenaria), or bay mussels (Mytilus edulis) exposed to a range of concentrations in 

estuarine/marine waters. 

.... , .. Practical Utility of tbe Data 

1. How would the data be used? 

Data would be used to determine a 48-h LC50 for dead larvae and EC50 for abnormally developed 

larvae (with 95% confidence intervals), along with a LOEC (lowest observable effect concentration) 

and NOEC. Normal larvae are those that are alive with completely developed shells containing 

meat. 

2. How could the data affect the risk assessment? 

There are many mussel species that are listed as threatened and endangered in the United States. 

Crassostrea virginica is considered as a surrogate species to represent all estuarine/marine 

invertebrates in the risk assessment process. As part of the acute risk assessment for aquatic animals, 

the lowest EC50 or LC50 for estuarine/marine invertebrates is used in the RQ equation. An acute RQ 

> 0.5 would indicate an acute LOC, defined as the potential for acute risk to non-target organisms 

which may warrant regulatory action in addition to restricted use classification. An acute RQ > 0.11 

would result in an acute restricted use LOC, defined as the potential for acute risk to non-target 

organisms, which may be mitigated through restricted use classification. An acute RQ > 0.05 

would fall under the LOC for acute endangered species. 

3. What is triggering the need for this data? 

Data are needed in order to conduct an ecological risk assessment for the proposed use of OBCP as 

a wood preservative and determine the acute toxicity of OBCP to estuarine/marine mollusks. . .. -

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EPA's Records Disposition Schedule PEST 361 Scientific Data Reviews HED Records Center - File R192301 - Page 23 of 24 

--- Guideline Number: 850.1710 

Data Requirement: Aquatic Bioavailability: Oyster BCF 

Guideline Number: 850.1730 

Data Requirement: Aquatic Bioavailability: Fish BCF 

Rationale for Requiring the Data 

The value of these studies is that freshwater and/or marine aquatic species of invertebrates and 

vertebrates can be examined to determine if a pesticide has the potential to accumulate in body 

tissues directly through bioconcentration from the water and/or indirectly through biomagnification 

via food transfer up the food chain. 

Practical Utility of the Data 

1. How will the data be used? 

In the oyster (850.1710) and fish (850.1730) BCF tests, parameters include mortality, abnormalities, 

steady-state or maximum bioconcentration factors (BCF) and uptake and depuration rate constants. 

Additionally, the major degradates can be identified and quantified at steady state. Typically, the 

categories include insect nymphs, crustaceans, mollusks, and fish (bottom-feeding, cold-water, and 

warm-water or marine). 

2. How could the data affect the risk assessment? 

In the risk assessment process, direct effects LOCs for each taxonomic group are used to make 

inferences concerning the potential for indirect effects upon listed species that rely upon nonendangered organisms. Information on the bioconcentration from water would assist risk assessors in 

making the inferences about indirect effects. 

3. What is triggering the need for this data? 

Data are needed in order to conduct an ecological risk assessment for the proposed use of OBCP as a 

wood preservative and determine any potential bioconcentration from the water. ---

Sign-off Date : 04111111 

DP Barcode No. : D383098 

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EPA's Records Disposition Schedule PEST 361 Scientific Data Reviews HED Records Center - File R192301 - Page 24 of 24 

062202 

062203 

~ 13544 

R192301 

Chemical Name: 2-Benzyl-4-chlorophenol 

Potassium 2-benzyl-4-chlorophenate 

Sodium 2-benzyl-4-chlorophenate 

PC Code: 062201 

HED File Code: 

Memo Date: 

File ID: 

Accession #: 

90832 AD RASSB Ecological Environmental Scoping Documents 

4/1112011 

00000000 

000-00-0137 

HED Records Reference Center 

5/17/2011