Initial to indicate certification as to information on this page (full text of certification is on page one). Date INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary. 2. Case # and Name 3. Date and Type of DCI and Number

4. EPA Product Registration 5. I wish to cancel this product registration voluntarily 6. Generic Data 7. Product Specific Data 6a. I am claiming a Generic Data Exemption because I obtain the active ingredient from the source EPA registration number listed below. 6b. I agree to satisfy Generic Data Requirements as indicated on the attached form entitled "Requirements Status and Registrant's Response." 7a. My product is an MUP and I agree to satisfy the MUP requirement on the attached form entitled "Requirements Status and Registrant's Response." 7b. My product is an EUP and I agree to satisfy the EUP requirement on the attached form entitled "Requirements Status and Registrant's Response." OMB Approval 2070-0174

1. Company Name and Address N/A - Metalaxyl-M Chemical # and Name: 113502 D-Alanine, N-(2,6-dimethylphenyl)-N-(methoxyacetyl)-, methyl ester 17-Jun-2011 GENERIC ID # GDCI-113502-940 

### United States Environmental Protection Agency

Washington, D.C. 20460 DATA CALL-IN RESPONSE 1 Page of 1

8. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law. Signature and Title of Company's Authorized Representative ______________________________________________________ 10. Name of Company N/A N/A

9. Date

11. Phone NumberInitial to indicate certification as to information on this page (full text of certification is on page one) 13. Phone Number 10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.
12. Name of Company 11. Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________

Nontarget Plant Protection Data Requirements (Conventional Chemical)

Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical) 850.4100 850.4150 850.4400

850.1010 850.1025 850.1035 850.1075 Terrestrial Plant Toxicity (Seedling Emergence)

Terrestrial plant toxicity, Tier 1 (vegetative vigor) Aquatic plant toxicity test using Lemna spp. Tiers I and II
Aquatic invertebrate acute toxicity, test, freshwater daphnids Oyster acute toxicity test (shell deposition) Mysid acute toxicity test Fish acute toxicity test, freshwater and marine N/A - Metalaxyl-M Chemical # and Name: 113502 D-Alanine, N-(2,6-dimethylphenyl)-N-(methoxyacetyl)-, methyl ester 17-Jun-2011 GENERIC ID # GDCI-113502-940

C,Q,A,B C,Q,A,B C,Q,A,B

C,Q,A,B C,Q,A,B C,Q,A,B C,Q,A,B TEP TEP EP; PAI; TGAI

TGAI, TEP TGAI, TEP TGAI, TEP TGAI, TEP 12 12 12

24 12 12 18 1 of Page

(2, 5, 8, 23) (1, 5, 7, 23) (6, 18, 22)

(20) (13, 14) (12) (10, 11, 15, 16) N N N

N N N N 2Date OMB Approval 2070-0174 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Terrestrial and Aquatic Nontarget Organisms Data Requirements (Conventional Chemical)

Toxicology Data Requirements (Conventional Chemical) 850.1350 850.2100

870.6200 870.7800 Mysid chronic toxicity test

Avian acute oral toxicity test

Neurotoxicity screening battery Immunotoxicity N/A - Metalaxyl-M Chemical # and Name: 113502 D-Alanine, N-(2,6-dimethylphenyl)-N-(methoxyacetyl)-, methyl ester 17-Jun-2011 GENERIC ID # GDCI-113502-940

C,Q,A,B C,Q,A,B

C,Q,A,B C,Q,A,B TGAI EP; PAI; TGAI

TGAI TGAI 12 12

24 12 2 of Page

(19) (3, 17)
(21) (4, 9) N

Y

N Y 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Metalaxyl-M GDCI-113502-940

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

Refer to public draft guideline 850.4250 for guidance on Tier II vegetative vigor testing. Refer to public draft guideline 850.4225 for guidance on Tier II seedling emergence testing. Protocol must be submitted to the Agency for review and approval prior to study inception. The draft protocol must be submitted to the Agency within 90 day receipt of this Data Call-In. Protocol must be submitted to the Agency for review and approval prior to study inception. The draft protocol must be submitted to the Agency within 90 day of receipt of this Data Call-In. Data are required for six species of dicots from at least four families, one species of which is soybean (Glycine max). Data are required for four species of monocots from at least two families, one species which is corn (Zea mays). At least one of either the monocot or dicot species must be a root crop. Data are required for a freshwater green alga species, a freshwater diatom species, a marine diatom species, and a cyanobacterium (formerly known as blue-green algae). Acceptable terrestrial plant toxicity data (vegetative vigor) for mefenoxam TEP are required. Acceptable terrestrial plant toxicity data (seedling emergence) for mefenoxam TEP are required. Acceptable immunotoxicity data for mefenoxam TGAI are required. Acceptable freshwater fish acute toxicity data for the rainbow trout and bluegill species for mefenoxam TEP are required. Acceptable freshwater fish acute toxicity data for the fathead minnow species for either metalaxyl TGAI or mefenoxam TGAI are required. Acceptable estuarine and marine organism acute toxicity data for the mysid species for mefenoxam TEP are required. Acceptable estuarine and marine organism acute toxicity data for the bivalve - oyster species for mefenoxam TEP are required. Acceptable estuarine and marine organism acute toxicity data for the bivalve - oyster species for either metalaxyl TGAI or mefenoxam TGAI are required. Acceptable estuarine and marine organism acute toxicity data for saltwater fish species for mefenoxam TEP are required. Acceptable estuarine and marine organism acute toxicity data for saltwater fish species for either metalaxyl TGAI or mefenoxam TGAI are required. Acceptable avian acute oral toxicity data for the passerine species for either metalaxyl TGAI or mefenoxam TGAI are required. Case # and Name: DCI Number: 1 Page: of

Footnotes: The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement. Use Categories Key: A - Terrestrial food crop B - Terrestrial feed crop C - Terrestrial nonfood crop Q - Residential outdoor use 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Metalaxyl-M GDCI-113502-940

18 19 20 21 22

23 Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

Acceptable aquatic plant toxicity data for either metalaxyl TGAI or mefenoxam TGAI are required. Acceptable aquatic invertebrate life cycle data for saltwater mysid species for either metalaxyl TGAI or mefenoxam TGAI are required. Acceptable aquatic invertebrate acute toxicity data for the waterflea (Daphnia magna) species for mefenoxam TEP are required. Acceptable acute and 90-day neurotoxicity screening battery data for the rat species for mefenoxam TGAI are required. A Tier II study is required. A Tier I plant study may be conducted in lieu of a Tier II study with the understanding that any adverse effects observed by the Tier I study would necessitate conduct and submission of a Tier II study as well. The purpose of a Tier II study is to establish both a definitive No Observed Adverse Effect Concentration (NOAEC), or alternatively, a concentration at which there is a 5% observed inhibition effect (IC05), to be used in a risk assessment and effects determination for endangered or threatened species (listed species), and a definitive IC50 (concentration at which there is a 50% observed inhibition effect) for assessing risk to non-listed nontarget plants. If any adverse effects are observed in a Tier I study and neither a definitive NOAEC nor a definitive IC05 value is available, then the Agency may have to presume in its effects determination, that metalaxyl "may affect" and is "likely to adversely affect" listed plant species. A Tier II study is required. A Tier I plant study may be conducted in lieu of a Tier II study with the understanding that any adverse effects observed by the Tier I study would necessitate conduct and submission of a Tier II study as well. The purpose of a Tier II study is to establish both a definitive No Observed Adverse Effect Concentration (NOAEC), or alternatively, a concentration at which there is a 5% observed inhibition effect (IC05), to be used in a risk assessment and effects determination for endangered or threatened species (listed species), and a definitive IC25 (concentration at which there is a 25% observed inhibition effect) for assessing risk to non-listed nontarget plants. If any adverse effects are observed in a Tier I study and neither a definitive NOAEC nor a definitive IC05 value is available, then the Agency may have to presume in its effects determination, that metalaxyl "may affect" and is "likely to adversely affect" listed plant species. Case # and Name: DCI Number: 2 Page: of 2

### United States Environmental Protection Agency Washington, D.C. 20460 LIST OF ALL REGISTRANTS SENT THIS DATA CALL-IN NOTICE N/A - Metalaxyl-M Case # and Name: 1 Page: of 1

100 SYNGENTA CROP PROTECTION, LLC Co. Nr. Company Name Agent For Company 410 SWING ROAD, P.O. Box 18300 Address City ZIP GREENSBORO 274198300 OMB Approval 2070-0174

State NC DCI Number: GDCI-113502-940

# LINKS TO FORMS: The pesticide registration forms that are listed below can be found at: http://www.epa.gov/opprd001/forms/ Link to C onfidential Statement of Formula and Instructions (Form # 8570 -4 

# ) http://www.epa.gov/opprd001/forms/8570 - 4.pdf C ertification of Attempt to Enter Into an Agreement With Registrants for Development of Data (Form # 8570 - 32 

# ) http://www.epa.gov/opprd001/forms/8570 - 32.pdf
C ertification With Respect to Citation of Data (Form # 8570 - 34 

# ) http://www.epa.gov/opprd001/forms/8570 - 34.pdf