Exhibit 10.1


 


[*]
Certain information in this document has been omitted from this exhibit because it is both 

(i) not material and (ii) would be competitively
harmful if publicly disclosed.


 


FIRST
AMENDMENT TO SPONSORED RESEARCH AGREEMENT


 


This
First Amendment to Sponsored Research Agreement (the “First Amendment”) made and entered into as of __________, 2022
(the “First Amendment Effective Date”), by and between SILO PHARMA, INC. (“Company”) and THE TRUSTEES
OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (“Columbia”).


 


WHEREAS,
the Company and Columbia entered into that certain Sponsored Research Agreement, dated October 1, 2021 (the “Agreement”),
a copy of which is annexed hereto as Exhibit 1; and


 


WHEREAS,
the parties now desire to amend the Agreement to extend the Research Period and modify the payment schedule;


 


NOW,
THEREFORE, for good and valuable consideration, the receipt and sufficiency of which are hereby mutually acknowledged, and intending
to be legally bound hereby, agree as follows:


 


	1.	Capitalized
                                            terms used herein without definition herein shall have the meaning given such terms in the
                                            Agreement.



 


	2.	The
                                            first paragraph of Section 3 of the Agreement is hereby amended to be and read as follows:



 


Support
for the Laboratory: Support for the Laboratory. During the beginning on the date of this Agreement and ending on March 31,
2023 (the “Research Period”), the Company shall pay a total of$ $[*] US to Columbia for the support of the Research,
payable to Columbia according to payment schedule in Exhibit A, in advance. The first payment will be due within ten (10) days after
the date of this Agreement, with subsequent payments due according to the payment schedule in Exhibit A. Checks shall be drawn to the
account of The Trustees of Columbia University in the City of New York and mailed to the following address. Please indicate the sponsor’s
name, the investigator’s name, and the sponsored project account, if known.


 


	3.	The
payment schedule contained in Exhibit A to the Agreement shall be modified as follows:



 


		a.	[*]%
                                            at [*] - $[*]



 


		b.	[*]%
                                            at [*] - $[*]



 


		c.	[*]%
                                            at [*] - $[*]



 


		d.	[*]%
                                            at [*] - $[*]



 






     


     


    

 


	4.	This
                                            First Amendment shall be construed and interpreted in accordance with the laws of the State
                                            of New York without giving effect to the conflict of laws rules thereof or the actual domiciles
                                            of the parties.



 


	5.	Except
                                            as amended hereby, the terms and conditions of the Agreement shall remain in full force and
                                            effect in all other respects, unless further amended by written agreement, and the Agreement
                                            is in all respects ratified and confirmed. On and after the date of this First Amendment,
                                            each reference in the Agreement to the “Agreement”, “hereinafter”, “herein”,
                                            “hereinafter”, “hereunder”, “hereof”, or words of like import
                                            shall mean and be a reference to the Agreement as amended by this First Amendment.



 


	6.	This
                                            First Amendment may be executed in any number of counterparts (facsimile and electronic transmission
                                            included), each of which shall be deemed an original, but all of which shall constitute one
                                            and the same instrument.



 


IN
WITNESS WHEREOF, each of the parties hereto has caused this First Amendment to be executed by their duly authorized representatives
as of the First Amendment Effective Date.


 


	THE TRUSTEES
    OF COLUMBIA UNIVERSITY	SILO PHARMA,
    INC.
	IN THE CITY OF NEW YORK	 


 


	By:	/s/
    Scott Hamilton 	 	By:	/s/
    Eric Weisblum 
	 	 	 	 	 
	Name:	Scott
    Hamilton 	 	Name:	Eric
    Weisblum 
	 	 	 	 	 
	Title:	AVP 	 	Title:	Chief
    Executive Officer 
	 	 	 	 	 
	Date:	 October
    13, 2022	 	Date:	October
    3, 2022 


 


TTS:
[*]


 


	READ AND ACKNOWLEDGED:	 
	/s/
    Christine Ann Denny 	 
	Dr. Christine Denny