EX-10.2




 Exhibit 10.2 

TENDER AND SUPPORT AGREEMENT 

This TENDER AND SUPPORT AGREEMENT (this “Agreement”), dated as of October 23, 2022, is entered into by and among
Alliance Holdco Limited, a private limited company organized under the laws of England and Wales (“Parent”), Alliance Acquisition Sub, Inc., a Delaware corporation and a wholly-owned Subsidiary of Parent
(“Purchaser”), and each of the individuals or entities set forth on Schedule A (each, a “Stockholder” and collectively, the “Stockholders”). All terms used but not
otherwise defined in this Agreement shall have the respective meanings ascribed to such terms in the Merger Agreement (as defined below). Parent, Purchaser and each of the Stockholders are each sometimes referred to herein as a
“Party” and collectively, as the “Parties.” 
 WHEREAS, as of the date hereof, each Stockholder is the
record and/or beneficial owner (as defined in Rule 13d-3 under the Exchange Act) of the number of Shares, RSUs, Company Options and Company Warrants, if any, in each case set forth opposite such
Stockholder’s name on Schedule A (all such Shares, RSUs, Company Options and Company Warrants set forth on Schedule A next to the Stockholder’s name, together with any Shares or any other securities of the Company that are
hereafter issued to or otherwise directly or indirectly acquired by such Stockholder prior to the valid termination of this Agreement in accordance with Section 5.02, including for the avoidance of doubt any Shares acquired
by such Stockholder upon the vesting of RSUs or upon exercise of Company Options or Company Warrants after the date hereof, being referred to herein as the “Subject Shares”); 

WHEREAS, concurrently with the execution hereof, Parent, Purchaser and Applied Genetic Technologies Corporation, a Delaware corporation (the
“Company”), are entering into an Agreement and Plan of Merger, dated as of the date hereof (as it may be amended from time to time pursuant to the terms thereof, the “Merger Agreement”), which provides, among other
things, for Purchaser to commence a tender offer to purchase all of the issued and outstanding Shares and, following completion of the Offer, for the Merger of Purchaser with and into the Company, in each case, on the terms and subject to the
conditions set forth in the Merger Agreement; and 
 WHEREAS, as a condition to Parent’s and Purchaser’s willingness to enter into
the Merger Agreement, and as an inducement and in consideration for them to enter into the Merger Agreement, each Stockholder, severally and not jointly, and on such Stockholder’s own account with respect to the Subject Shares, has agreed to
execute and deliver this Agreement, pursuant to which each Stockholder, among other things, has agreed to tender all Shares beneficially owned by such Stockholder to Purchaser in the Offer. 

NOW, THEREFORE, in consideration of the foregoing and the respective representations, warranties, covenants and agreements set forth below and
for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties, intending to be legally bound, do hereby agree as follows: 











 ARTICLE I 

AGREEMENT TO TENDER AND VOTE 

Section 1.01 Agreement to Tender. Subject to the terms of this Agreement, each Stockholder hereby agrees to validly and
irrevocably tender or cause to be validly and irrevocably tendered in the Offer all of such Stockholder’s Subject Shares (other than RSUs that are not vested and Company Options and Company Warrants that are not exercised during the term of
this Agreement) pursuant to and in accordance with the terms of the Offer, free and clear of all Encumbrances, except for Permitted Encumbrances (as defined below). Without limiting the generality of the foregoing, as promptly as practicable after,
but in no event later than ten (10) Business Days after, the commencement (within the meaning of Rule 14d-2 under the Exchange Act) of the Offer (or, in the case of any Shares acquired by such Stockholder
subsequent to such tenth (10th) Business Day, within two (2) Business Days after the acquisition of such Shares and in any event prior to the End Date), each Stockholder shall deliver or
cause to be delivered pursuant to the terms of the Offer (a) a letter of transmittal with respect to all of such Stockholder’s Subject Shares complying with the terms of the Offer, (b) a certificate representing all such Subject
Shares that are certificated or, in the case of a Book Entry Share of any uncertificated Subject Shares, written instructions to such Stockholder’s broker, dealer or other nominee that such Subject Shares be tendered, including a reference to
this Agreement, and requesting delivery of an “agent’s message” (or such other evidence, if any, of transfer as the Paying Agent may reasonably request) with respect to such Subject Shares, and (c) all other customary documents
or instruments that Parent or Purchaser may reasonably require or request in order to effect the valid tender of such Stockholder’s Subject Shares in accordance with the terms of the Offer (it being understood that this sentence shall not apply
to RSUs that are not vested and Company Options and Company Warrants that are not exercised during the term of this Agreement). Each Stockholder agrees that such Stockholder will not withdraw and will cause not to be withdrawn such Subject Shares
from the Offer at any time, unless and until this Agreement shall have been validly terminated in accordance with Section 5.02. 

Section 1.02 Agreement to Vote. Subject to the terms of this Agreement, each Stockholder hereby irrevocably and unconditionally
agrees that, during the time this Agreement is in effect, at any annual or special meeting of the stockholders of the Company, however called, including any adjournment or postponement thereof, and in connection with any action proposed to be taken
by written consent of the stockholders of the Company, such Stockholder shall, in each case to the fullest extent that such Stockholder’s Subject Shares are entitled to vote thereon: (a) appear at each such meeting or otherwise cause all
such Subject Shares to be counted as present thereat for purposes of determining a quorum and (b) be present (in person or by proxy) and vote (or cause to be voted), or deliver (or cause to be delivered) a written consent with respect to, all
of such Stockholder’s Subject Shares (i) against any action or agreement that is intended or would reasonably be expected to (A) result in a breach of any covenant, representation or warranty or any other obligation or agreement of
the Company contained in the Merger Agreement, or of any Stockholder contained in this Agreement, or (B) result in any of the conditions set forth in Section 6 or Exhibit E of the Merger Agreement not being
satisfied on or before the End Date, (ii) against any Acquisition Proposal, (iii) against any change in membership of the Company Board, (iv) against any other proposed action, agreement or transaction involving the Company that is
intended, or would reasonably be expected, to impede, 

  
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interfere with, delay, postpone, adversely affect or prevent the consummation of the Offer, the Merger or the other transactions contemplated by the Merger Agreement, including (x) any
extraordinary corporate transaction, such as a merger, consolidation or other business combination involving the Company (other than the Merger), (y) a sale, lease, license or transfer of a material amount of assets (including, for the avoidance of
doubt, intellectual property rights) of the Company or any reorganization, recapitalization or liquidation of the Company or (z) any change in the present capitalization of the Company or any amendment or other change in the Company’s
organizational documents, and (v) in favor of any other matter necessary to the consummation of the Merger Agreement, the Offer, the Merger and the other transactions contemplated by the Merger Agreement. Each Stockholder shall retain at all
times the right to vote such Stockholder’s Subject Shares in such Stockholder’s sole discretion, and without any other limitation, on any matters other than those set forth in this Section 1.02 that are at any time or from time to
time presented for consideration to the Company’s stockholders generally. 
 ARTICLE II 

REPRESENTATIONS AND WARRANTIES OF THE STOCKHOLDERS 

Each Stockholder represents and warrants, on such Stockholder’s own account with respect to the Subject Shares, to Parent and Purchaser
as to such Stockholder on a several basis, that: 
 Section 2.01 Authorization; Binding Agreement. If such Stockholder is not an
individual, such Stockholder is duly organized and validly existing and in good standing (in the case of good standing, to the extent such jurisdiction recognizes such concept) under the Legal Requirements of the jurisdiction in which it is
incorporated or constituted and the consummation of the transactions contemplated hereby is within such Stockholder’s entity powers and has been duly authorized by all necessary entity actions on the part of such Stockholder, and such
Stockholder has full power and authority to execute, deliver and perform such Stockholder’s obligations under this Agreement and to consummate the transactions contemplated hereby. If such Stockholder is an individual, such Stockholder has full
legal capacity, right and authority to execute and deliver this Agreement and to perform such Stockholder’s obligations hereunder. This Agreement has been duly and validly executed and delivered by such Stockholder and constitutes a valid and
binding obligation of such Stockholder enforceable against such Stockholder in accordance with its terms, subject to the Enforceability Exceptions. 

Section 2.02 Non-Contravention. Neither the execution and delivery of this Agreement by
such Stockholder nor the consummation of the transactions contemplated hereby nor compliance by such Stockholder with any provisions herein will (a) if such Stockholder is not an individual, violate, contravene or conflict with or result in any
breach of any provision of the certificate of incorporation or bylaws (or other similar governing documents) of such Stockholder, (b) require any consent, approval, authorization or permit of, or filing with or notification to, any Governmental
Body on the part of such Stockholder, except for compliance with the applicable requirements of the Securities Act, the Exchange Act or any other United States or federal securities laws and the rules and regulations promulgated thereunder,
(c) violate, conflict with, or result in a breach of any provisions of, or require any consent, waiver or approval or result in a default or loss of a benefit (or give rise to any right of termination, cancellation, modification or acceleration
or any event that, with the giving of notice, the passage 

  
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of time or otherwise, would constitute a default or give rise to any such right) under, any of the terms, conditions or provisions of any Contract to which such Stockholder is a party or by which
such Stockholder or any of such Stockholder’s assets may be bound, (d) result (or, with the giving of notice, the passage of time or otherwise, would result) in the creation or imposition of any Encumbrance on any Subject Shares of such
Stockholder (other than one created by Parent or Purchaser), or (e) violate any Legal Requirement or Order applicable to such Stockholder or by which any of such Stockholder’s Subject Shares are bound, except as would not, in the case of
each of clauses (c), (d) and (e), adversely affect in any material respect such Stockholder’s ability to timely perform such Stockholder’s obligations under this Agreement. No trust of which the Stockholder is a trustee requires the
consent of any beneficiary to the execution and delivery of this Agreement or to the consummation of the transactions contemplated hereby. 

Section 2.03 Ownership of Subject Shares; Total Shares. As of the date hereof, such Stockholder is, and (except with respect to
any Subject Shares Transferred in accordance with Section 4.01 or accepted for payment pursuant to the Offer) at all times during the Agreement Period (as defined below) will be, the record and/or beneficial owner (as
defined in Rule 13d-3 under the Exchange Act) of all such Stockholder’s Subject Shares and has good and marketable title to all such Subject Shares free and clear of any Encumbrances, except for
(a) any such Encumbrance that may be imposed pursuant to (i) this Agreement and (ii) any applicable restrictions on transfer under the Securities Act or any state securities law and (b) community property interests under
applicable Legal Requirements (collectively, “Permitted Encumbrances”). Except to the extent of any Subject Shares acquired after the date hereof (which shall become Subject Shares upon such acquisition), the number of Subject
Shares (as set forth on Schedule A opposite such Stockholder’s name) are the only equity interests in the Company beneficially owned or owned of record by such Stockholder as of the date hereof. Other than the Subject Shares, such
Stockholder does not own any Shares, RSUs, Company Options, Company Warrants or any other interests in options to purchase or rights to subscribe for or otherwise acquire any securities of the Company and has no interest in or voting rights with
respect to any securities of the Company. 
 Section 2.04 Voting Power. Such Stockholder has full voting power with respect to
all such Stockholder’s Subject Shares, and full power of disposition, full power to issue instructions with respect to the matters set forth herein and full power to agree to all of the matters set forth in this Agreement, in each case with
respect to all such Stockholder’s Subject Shares. None of such Stockholder’s Subject Shares are subject to any stockholders’ agreement, proxy, voting trust or other agreement or arrangement with respect to the voting of such Subject
Shares, except as provided pursuant to this Agreement. 
 Section 2.05 Reliance and Merger Agreement. Such Stockholder
understands and acknowledges that Parent and Purchaser are entering into the Merger Agreement in reliance upon such Stockholder’s execution, delivery and performance of this Agreement. Such Stockholder has reviewed and understands the terms of
this Agreement and the Merger Agreement, and has had the opportunity to consult with such Stockholder’s counsel in connection with this Agreement. 

  
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 Section 2.06 Absence of Litigation. With respect to such Stockholder, as of the
date hereof, there is no Legal Proceeding pending against, or, to the knowledge of such Stockholder, threatened against such Stockholder or any of such Stockholder’s properties or assets (including any Shares, RSUs, Company Options or Company
Warrants beneficially owned by such Stockholder) that could reasonably be expected to prevent or materially delay or impair the consummation by such Stockholder of the transactions contemplated by this Agreement or otherwise materially impair such
Stockholder’s ability to perform such Stockholder’s obligations hereunder. 
 Section 2.07 Brokers. No broker, finder,
financial advisor, investment banker or other Person is entitled to any brokerage, finder’s, financial advisor’s or other similar fee or commission from the Company in connection with the transactions contemplated hereby based upon
arrangements made by or on behalf of such Stockholder in such Stockholder’s capacity as such. 
 ARTICLE III 

REPRESENTATIONS AND WARRANTIES OF PARENT AND PURCHASER 

Parent and Purchaser represent and warrant to the Stockholders that: 

Section 3.01 Organization and Qualification. Each of Parent and Purchaser is duly organized and validly existing and in good
standing (in the case of good standing, to the extent such jurisdiction recognizes such concept) under the Legal Requirements of the jurisdiction in which it is incorporated or constituted. 

Section 3.02 Authority for this Agreement. Each of Parent and Purchaser has all requisite entity power and authority to execute,
deliver and perform its obligations under this Agreement and to consummate the transactions contemplated hereby. The execution and delivery of this Agreement by Parent and Purchaser have been duly and validly authorized by all necessary entity
action on the part of each of Parent and Purchaser, and no other corporate or other entity proceedings on the part of Parent and Purchaser are necessary to authorize this Agreement. This Agreement has been duly and validly executed and delivered by
Parent and Purchaser and, assuming the due authorization, execution and delivery by the Stockholder, constitutes a legal, valid and binding obligation of each of Parent and Purchaser, enforceable against each of Parent and Purchaser in accordance
with its terms, subject to the Enforceability Exceptions. 
 ARTICLE IV 

ADDITIONAL COVENANTS OF THE STOCKHOLDERS 

Each Stockholder hereby covenants and agrees that, until the valid termination of this Agreement in accordance with
Section 5.02: 
 Section 4.01 No Transfer; No Inconsistent Arrangements. Except as provided hereunder
or under the Merger Agreement, from and after the date hereof and until this Agreement is validly terminated in accordance with Section 5.02, such Stockholder shall not, directly or indirectly, (a) create or permit to
exist any Encumbrance, other than a Permitted Encumbrance, on any of such Stockholder’s Subject Shares, (b) transfer, sell (including short 

  
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sell), assign, gift, hedge, pledge, grant a participation interest in, hypothecate or otherwise dispose of, or enter into any derivative arrangement with respect to (collectively,
“Transfer”), any of such Stockholder’s Subject Shares, or any right or interest therein (or consent to any of the foregoing), (c) enter into any Contract with respect to any Transfer of such Stockholder’s Subject Shares or
any interest therein, (d) grant or permit the grant of any proxy, power-of-attorney or other authorization or consent in or with respect to any such
Stockholder’s Subject Shares, (e) deposit or permit the deposit of any of such Stockholder’s Subject Shares into a voting trust or enter into a voting agreement or arrangement with respect to any of such Stockholder’s Subject
Shares, or (f) take (or fail to take) or permit any other action that would in any way restrict, limit, impede, delay or interfere with the performance of such Stockholder’s obligations hereunder in any material respect, otherwise make any
representation or warranty of such Stockholder herein untrue or incorrect, or have the effect of preventing or disabling such Stockholder from performing any of such Stockholder’s obligations under this Agreement. Any action taken in violation
of the foregoing sentence shall be null and void ab initio. Each Stockholder hereby authorizes Parent to direct the Company to impose stop orders to prevent the Transfer of any Subject Shares on the books of the Company in violation of this
Agreement. Notwithstanding the foregoing, (x) any Stockholder that is an individual may Transfer Subject Shares (i) to any member of such Stockholder’s immediate family, (ii) to a trust for the sole benefit of such Stockholder or
any member of such Stockholder’s immediate family, the sole trustees of which are such Stockholder or any member of such Stockholder’s immediate family, (iii) by will or under the laws of intestacy upon the death of such Stockholder
or (iv) to any charitable organization and (y) any Stockholder that is an entity may Transfer Subject Shares to any Affiliate of such Stockholder; provided that a transfer referred to in clauses (x) and (y) of this sentence
shall be permitted only if (A) all of the representations and warranties in Article II with respect to the transferee of such Subject Shares would be true and correct in all material respects upon such Transfer, subject to necessary
adjustment as a result of such Transfer, (B) the transferee shall have executed and delivered to Parent and Purchaser a counterpart to this Agreement pursuant to which such transferee shall be bound by all of the terms and provisions of this
Agreement and agree and acknowledge that such Person shall constitute a Stockholder for all purposes of this Agreement and (C) such Transfer occurs no later than three (3) Business Days prior to the end of the Agreement Period. If any
involuntary Transfer of any of such Stockholder’s Subject Shares in the Company shall occur (including a sale by such Stockholder’s trustee in any bankruptcy, or a sale to a purchaser at any creditor’s or court sale), the transferee
(which term, as used herein, shall include any and all transferees and subsequent transferees of the initial transferee) shall take and hold such Subject Shares subject to all of the restrictions, liabilities and rights under this Agreement, which
shall continue in full force and effect until the valid termination of this Agreement in accordance with Section 5.02. Each Stockholder agrees that such Stockholder shall not, and shall cause each of such Stockholder’s
Affiliates not to, become a member of a “group” (as defined under Section 13(d) of the Exchange Act) for the purpose of taking any actions inconsistent with the transactions contemplated by this Agreement or the Merger Agreement.
Notwithstanding the foregoing, such Stockholder may make Transfers of such Stockholder’s Subject Shares as Parent may agree in writing in its sole discretion. Each Stockholder shall notify Parent as promptly as practicable (and in any event
within 48 hours after receipt) in writing of the number of any additional Shares of which such Stockholder acquires beneficial or record ownership on or after the date hereof. 

  
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 Section 4.02 No Exercise of Appraisal Rights. Such Stockholder forever waives
and agrees not to exercise any appraisal rights or dissenters’ rights, including pursuant to Section 262 of the DGCL, in respect of such Stockholder’s Subject Shares that may arise in connection with the Offer or the Merger. 

Section 4.03 Documentation and Information. Such Stockholder shall not make any public announcement regarding this Agreement and
the transactions contemplated hereby without the prior written consent of Parent (such consent not to be unreasonably withheld), except as may be required by applicable Legal Requirement (provided that reasonable notice of any such disclosure
will be provided to Parent). Such Stockholder consents to and hereby authorizes Parent and Purchaser to publish and disclose in all documents and schedules filed with the SEC, including, Schedule TO and Schedule
14D-9, and any press release or other disclosure document that Parent or Purchaser reasonably determines to be necessary in connection with the Offer, the Merger and any transactions contemplated by the Merger
Agreement, such Stockholder’s identity and ownership of the Subject Shares, the existence of this Agreement, the nature of such Stockholder’s commitments and obligations under this Agreement and any other information that Parent reasonably
determines is required to be disclosed by Legal Requirements, and such Stockholder acknowledges that Parent and Purchaser may, in Parent’s sole discretion, file this Agreement or a form hereof with the SEC or any other Governmental Body. Such
Stockholder agrees to promptly give Parent any information it may reasonably request for the preparation of any such disclosure documents, and such Stockholder agrees to promptly notify Parent of any required corrections with respect to any
information supplied by such Stockholder specifically for use in any such disclosure document, if and to the extent that any such information shall have become false or misleading in any material respect. 

Section 4.04 Adjustments. In the event of any stock split, stock dividend, merger, reorganization, recapitalization,
reclassification, combination, exchange of shares or the like of the capital stock of the Company affecting the Subject Shares, the terms of this Agreement shall apply to the resulting securities. 

Section 4.05 Waiver of Certain Actions. Each Stockholder hereby agrees not to commence or participate in, and to take all actions
necessary to opt out of any class in any class action with respect to, any claim, derivative or otherwise, against the Company, Parent, Purchaser or any of their respective Affiliates, successors, directors or officers relating to the negotiation,
execution or delivery of this Agreement or the Merger Agreement or the consummation of the Merger or the other transactions contemplated by the Merger Agreement, including any such claim (a) challenging the validity of, or seeking to enjoin or
delay the operation of, any provision of this Agreement or the Merger Agreement (including any claim seeking to enjoin or delay the acceptance of the Offer or the Closing) or (b) alleging a breach of any duty of the Company Board in connection
with the Merger Agreement, this Agreement or the transactions contemplated thereby or hereby, but excluding any such claim brought by a Stockholder as a third party beneficiary under Section 8.7 of the Merger Agreement. 

  
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 Section 4.06 No Solicitation. Each Stockholder, solely in such
Stockholder’s capacity as a stockholder of the Company, shall not, and shall direct such Stockholder’s Representatives and cause such Stockholder’s Affiliates and such Stockholder’s and such Affiliates’ respective directors,
officers and employees not to, directly or indirectly, (a) continue any solicitation, knowing encouragement, discussions or negotiations with any Persons that may be ongoing with respect to an Acquisition Proposal, (b)(i) solicit, initiate or
knowingly facilitate or knowingly encourage any inquiries or the making of any proposal or offer that constitutes, or could reasonably be expected to lead to, an Acquisition Proposal, (ii) engage in, continue or otherwise participate in any
discussions or negotiations regarding, or furnish to any other Person any non-public information in connection with an Acquisition Proposal or any proposal or offer that could reasonably be expected to lead to
an Acquisition Proposal, (c) enter into any letter of intent, acquisition agreement, agreement in principle or similar agreement with respect to an Acquisition Proposal or any proposal or offer that could reasonably be expected to lead to an
Acquisition Proposal, or (d) knowingly encourage or recommend any other holder of Shares to vote against the Merger or to not tender Shares into the Offer. Each Stockholder shall, and shall direct such Stockholder’s Representatives and
cause such Stockholder’s Affiliates and such Stockholder’s and such Affiliates’ respective directors, officers and employees to, immediately cease any solicitation, knowing encouragement, discussions or negotiations regarding with any
Person that may be ongoing with respect to an Acquisition Proposal or that could reasonably be expected to lead to an Acquisition Proposal. 

ARTICLE V 

MISCELLANEOUS 

Section 5.01 Notices. All notices, requests, claims, demands and other communications under this Agreement shall be in writing and
shall be deemed to have been duly given: (x) when delivered personally by hand, if delivered in Person; (y) on the date sent (if sent during normal business hours of the recipient and on the next Business Day if sent after normal business
hours of the recipient), if sent by email of a PDF Document (with written confirmation of receipt by other than automatic means, whether electronic or otherwise); (iii) three (3) Business Days after sending, if sent by registered or certified
mail (postage prepaid, return receipt requested); and (iv) one (1) Business Day after sending, if sent by overnight internationally recognized courier (with written confirmation of receipt), in each case, to such address or email address as a
Party may have specified by notice given to the other Party pursuant to this provision. 
 Section 5.02 Termination. This
Agreement shall terminate automatically with respect to a Stockholder, without any notice or other action by any Person, upon the first to occur of (a) the valid termination of the Merger Agreement in accordance with its terms, (b) the
Effective Time, (c) the termination of this Agreement by written notice from Parent to the Stockholders or (d) reduction of the per-Share consideration payable by Purchaser pursuant to the Offer (the
period from the date hereof through such time being referred to as the “Agreement Period”). Upon the valid termination of this Agreement in accordance with this Section 5.02, no Party shall have any further
obligations or liabilities under this Agreement; provided, however, that (x) nothing set forth in this Section 5.02 shall relieve any Party from liability for common law fraud or any willful and
intentional breach of this Agreement prior to termination hereof and (y) the provisions of this Article V shall survive any valid termination of this Agreement in accordance with this Section 5.02. 

  
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 Section 5.03 Amendments and Waivers. This Agreement may not be amended except by
an instrument in writing signed by the Parties during the Agreement Period, and no waiver of compliance by any Party with any of the conditions set contained herein shall be valid except if set forth in an instrument in writing signed by the Party
or Parties to be bound thereby. No failure or delay by any Party in exercising any right or remedy shall operate as a waiver thereof nor shall any single or partial exercise thereof preclude any other or further exercise thereof or the exercise of
any other right or remedy. 
 Section 5.04 Expenses. Each Party will bear such Party’s own expenses in connection with this
Agreement and the transactions contemplated hereby, whether or not the Offer or the Merger is consummated. 
 Section 5.05 Entire
Agreement; Assignment. This Agreement, together with Schedule A and the other documents and certificates delivered pursuant hereto, constitute the entire agreement and supersede all prior agreements and understandings, both written and
oral, among the Parties and their respective Affiliates, or any of them, with respect to the subject matter hereof. This Agreement shall not be assigned by any Party (including by operation of law, by merger or otherwise) without the prior written
consent of the other Parties; provided that Parent or Purchaser may assign, in their sole discretion, any of or all of their respective rights, interests an obligations under this Agreement to Parent or to any direct or indirect wholly-owned
Subsidiary of Parent, but no such assignment shall relieve Parent of its obligations hereunder. Any purported assignment without such consent shall be void. 

Section 5.06 Enforcement of the Agreement. The Parties agree that irreparable damage would occur in the event that any Stockholder
did not perform any of the provisions of this Agreement in accordance with their specific terms or otherwise breached any such provisions. It is accordingly agreed that Parent and Purchaser shall be entitled, in addition to any other remedy to which
they may be entitled at law or in equity, to an injunction or any other appropriate form of equitable relief, to compel specific performance and to prevent or restrain breaches or threatened breached of this Agreement in any action without the
posting of a bond or undertaking in connection with such remedy. The Stockholders shall, and hereby do, waive, in any action for specific performance, the defense of adequacy of a remedy at law and any other objections to specific performance of
this Agreement. Any and all remedies herein expressly conferred upon Parent and Purchaser will be deemed cumulative with and not exclusive of any other remedy conferred hereby, or by Legal Requirement or equity upon Parent or Purchaser, and the
exercise by Parent or Purchaser of any one remedy will not preclude the exercise of any other remedy. 
 Section 5.07 Jurisdiction;
Waiver of Jury Trial. 
 (a) Each Stockholder hereby: (i) expressly and irrevocably submits to the exclusive personal jurisdiction
of the Court of Chancery of the State of Delaware or, if such court lacks subject matter jurisdiction, the United States District Court for the District of Delaware with respect to any dispute arising out of, relating to or in connection with this
Agreement, any transaction contemplated hereby or the actions of Parent or Purchaser in the negotiation, administration, performance and enforcement in connection with this Agreement; (ii) agrees that it shall not attempt to deny or defeat such
personal jurisdiction by motion or other request for leave from any such court; and (iii) agrees that it shall not bring any action arising out of, relating to or in connection with this Agreement or any transaction contemplated by this


  
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Agreement in any court other than the Court of Chancery of the State of Delaware or, if such court lacks subject matter jurisdiction, the United States District Court for the District of
Delaware. Each Stockholder irrevocably and unconditionally waives any objection to the laying of venue of any Proceeding arising out of this Agreement or the transactions contemplated hereby in the Court of Chancery of the State of Delaware or in
any federal court located in the State of Delaware, and hereby further irrevocably and unconditionally waives and agrees not to plead or claim in any such court that any such Proceeding brought in any such court has been brought in an inconvenient
forum. Each Stockholder agrees that a final trial court judgment in any such Proceeding shall be conclusive and may be enforced in other jurisdiction by suit on the judgment or in any manner provided by Legal Requirement; provided that
nothing in the foregoing shall restrict any Party’s right to seek any post-judgment relief regarding, or any appeal from, such final trial court judgment. Each Stockholder hereby agrees that service of any process, summons, notice or document
by U.S. registered mail in accordance with Section 5.01 shall be effective service of process for any Legal Proceeding arising out of, relating to or in connection with this Agreement or the transactions contemplated
hereby. 
 (b) EACH PARTY ACKNOWLEDGES AND AGREES THAT ANY CONTROVERSY WHICH MAY ARISE UNDER THIS AGREEMENT IS LIKELY TO INVOLVE COMPLICATED
AND DIFFICULT ISSUES, AND THEREFORE EACH SUCH PARTY HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES ANY RIGHT SUCH PARTY MAY HAVE TO A TRIAL BY JURY IN ANY LITIGATION ARISING OUT OF, RELATING TO OR IN CONNECTION WITH THIS AGREEMENT. EACH STOCKHOLDER
CERTIFIES AND ACKNOWLEDGES THAT (I) NO REPRESENTATIVE AGENT OR ATTORNEY OF PARENT OR PURCHASER HAS REPRESENTED EXPRESSLY OR OTHERWISE, THAT PARENT OR PURCHASER WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING WAIVER,
(II) EACH STOCKHOLDER UNDERSTANDS AND HAS CONSIDERED THE IMPLICATION OF THIS WAIVER, (III) EACH STOCKHOLDER MAKES THIS WAIVER VOLUNTARILY, AND (IV) EACH STOCKHOLDER HAS BEEN INDUCED TO ENTER INTO THIS AGREEMENT BY, AMONG OTHER THINGS,
THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION. 
 Section 5.08 Governing Law. This Agreement, and any dispute arising
out of, relating to or in connection with this Agreement, shall be governed by, and construed in accordance with, the Legal Requirements of the State of Delaware, regardless of the Legal Requirements that might otherwise govern under applicable
principles of conflicts of laws thereof. 
 Section 5.09 Descriptive Headings. The descriptive headings contained in this
Agreement are included for convenience of reference only and will not affect in any way the meaning or interpretation of this Agreement. 

Section 5.10 Parties in Interest. This Agreement shall be binding upon, inure solely to the benefit of and be enforceable by each
Party and such Party’s respective successors, assigns, heirs and beneficiaries, and nothing in this Agreement, express or implied, is intended to confer upon any other Person any rights or remedies of any nature whatsoever under or by reason of
this Agreement. 

  
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 Section 5.11 Severability. If any term or other provision of this Agreement is
determined by a court of competent jurisdiction to be invalid, illegal or incapable of being enforced by any Legal Requirement or public policy, all other conditions and provisions of this Agreement shall nevertheless remain in full force and
effect. Upon such determination that any term or other provision is invalid, illegal or incapable of being enforced, the Parties shall negotiate in good faith to modify this Agreement so as to effect the original intent of the Parties as closely as
possible in a mutually acceptable manner so that the obligations and transactions contemplated by this Agreement are fulfilled to the fullest extent possible. 

Section 5.12 Counterparts. This Agreement may be executed and delivered in counterparts, each of which shall be deemed to be an
original, but all of which, taken together, shall constitute one and the same agreement. This Agreement or any counterpart may be executed and delivered by facsimile copies or delivered by electronic communications by portable document format
(.pdf), each of which shall be deemed an original. 
 Section 5.13 No Agreement Until Executed. This Agreement shall not be
effective unless and until (a) the Merger Agreement is executed by all parties thereto and (b) this Agreement is executed by all parties hereto. 

Section 5.14 Interpretation. When reference is made in this Agreement to a Section, such reference will be to a Section of this
Agreement unless otherwise indicated. Whenever the words “include,” “includes,” or “including” are used in this Agreement, they will be deemed to be followed by the words “without limitation.” The words
“hereof,” “herein,” “hereby,” “hereto,” and “hereunder” and words of similar import when used in this Agreement will refer to this Agreement as a whole and not to any particular provision of this
Agreement. The word “or” will not be exclusive. The phrases “date hereof” and “date of this Agreement” shall be deemed to refer to October 23, 2022. Whenever used in this Agreement, any noun or pronoun will be
deemed to include the plural as well as the singular and to cover all genders. All Exhibits annexed hereto or referred to herein are hereby incorporated in and made a part of this Agreement as if set forth in full herein. The word “will”
shall be construed to have the same meaning as the word “shall.” Any terms used in any Exhibit or any certificate or other document made or delivered pursuant hereto but not otherwise defined therein shall have the meaning as defined in
this Agreement. The word “extent” in the phrase “to the extent” shall mean the degree to which a subject or other thing extends, and such phrase shall not mean simply “if.” Unless the context requires otherwise,
(i) any reference herein to any Person shall be construed to include such Person’s successors and assigns, and (ii) all references herein to Articles, Sections and Exhibits shall be construed to refer to Articles and Sections of, and
Exhibits to, this Agreement. The Parties have participated jointly in the negotiation and drafting of this Agreement and, in the event an ambiguity or question of intent or interpretation arises, this Agreement shall be construed as jointly drafted
by the Parties and no presumption or burden of proof shall arise favoring or disfavoring any Party by virtue of the authorship of any provision of this Agreement. 

Section 5.15 Further Assurances. Each Stockholder will execute and deliver, or cause to be executed and delivered, all further
documents and instruments and use such Stockholder’s reasonable best efforts to take, or cause to be taken, all actions and to do, or cause to be done, all things necessary, proper or advisable under applicable Legal Requirements and
regulations, to perform such Stockholder’s obligations under this Agreement. 

  
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 Section 5.16 Capacity as Stockholder. Each Stockholder signs this Agreement
solely in such Stockholder’s capacity as a stockholder of the Company, and not, if applicable, in such Stockholder’s capacity as a director, officer or employee of the Company. Nothing herein shall in any way restrict a director or officer
of the Company in the taking of any actions (or failure to act) in his or her capacity as a director or officer of the Company, or in the exercise of his or her fiduciary duties as a director or officer of the Company, or prevent or be construed to
create any obligation on the part of any director or officer of the Company from taking any action in his or her capacity as such director or officer, and no action taken in any such capacity as an officer or director of the Company shall be deemed
to constitute a breach of this Agreement; provided that, for the avoidance of doubt, nothing herein shall be understood to relieve any party to the Merger Agreement of any obligation under, or of any liability for breach of any provision of,
the Merger Agreement. 
 Section 5.17 Representations and Warranties. The representations and warranties contained in this
Agreement and in any certificate or other writing delivered pursuant hereto shall not survive the Effective Time or the valid termination of this Agreement in accordance with Section 5.02. 

Section 5.18 Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not
joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Purchaser agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations
of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. 

[Remainder of Page Intentionally Left Blank; Signature Pages Follow] 

  
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 The Parties are executing this Tender and Support Agreement as of the date set forth in the
preamble. 
  

			
	ALLIANCE ACQUISITION SUB, INC.
		
	By:	 	 /s/ David Fellows

	Name:	 	David Fellows
	Title:	 	Director


  

			
	ALLIANCE HOLDCO LIMITED
		
	By:	 	 /s/ Dr. Christopher Hollowood

	Name:	 	Dr. Christopher Hollowood
	Title:	 	President



  
 [Signature
Page to Tender and Support Agreement] 












 
			
	By:	 	 /s/ Susan B. Washer

	Name:	 	Susan B. Washer
	Title:	 	Director, President and Chief Executive Officer



  
 [Signature
Page to Tender and Support Agreement] 












 
			
	By:	 	 /s/ Hope D’Oyley-Gay

	Name:	 	Hope D’Oyley-Gay
	Title:	 	General Counsel



  
 [Signature
Page to Tender and Support Agreement] 












 
			
	By:	 	 /s/ James Robinson

	Name:	 	James Robinson
	Title:	 	Director



  
 [Signature
Page to Tender and Support Agreement] 













			
	By:	 	 /s/ Susan Schneider

	Name:	 	Susan Schneider
	Title:	 	Chief Medical Officer



  
 [Signature
Page to Tender and Support Agreement] 












 
			
	By:	 	 /s/ Stephen Potter

	Name:	 	Stephen Potter
	Title:	 	Chief Business Officer



  
 [Signature
Page to Tender and Support Agreement] 












 
			
	By:	 	 /s/ Abraham Scaria

	Name:	 	Abraham Scaria
	Title:	 	Chief Scientific Officer



  
 [Signature
Page to Tender and Support Agreement] 












 
			
	By:	 	 /s/ Jonathan I. Lieber

	Name:	 	Jonathan I. Lieber
	Title:	 	Chief Financial Officer



  
 [Signature
Page to Tender and Support Agreement] 












 
			
	By:	 	 /s/ Anne VanLent

	Name:	 	Anne VanLent
	Title:	 	Director



  
 [Signature
Page to Tender and Support Agreement] 












 
			
	By:	 	 /s/ James Rosen

	Name:	 	James Rosen
	Title:	 	Director



  
 [Signature
Page to Tender and Support Agreement] 












 
			
	By:	 	 /s/ William Aliski

	Name:	 	William Aliski
	Title:	 	Director



  
 [Signature
Page to Tender and Support Agreement] 












 
			
	By:	 	 /s/ Edward Hurwitz

	Name:	 	Edward Hurwitz
	Title:	 	Director



  
 [Signature
Page to Tender and Support Agreement] 












 
			
	By:	 	 /s/ Yehia Hashad

	Name:	 	Yehia Hashad
	Title:	 	Director



  
 [Signature
Page to Tender and Support Agreement] 












 
			
	By:	 	 /s/ Scott Koenig

	Name:	 	Scott Koenig
	Title:	 	Director



  
 [Signature
Page to Tender and Support Agreement] 












 Schedule A 

 

																	
	 Name of Beneficial Owner
	  	Number of Shares	 	  	Number of RSUs	 	  	Company Options	 	  	Company Warrants	 
	 Susan B. Washer
	  	 	143,021	 	  	 	0	 	  	 	1,640,936	 	  	 	0	 
	 Jonathan I. Lieber
	  	 	0	 	  	 	0	 	  	 	356,700	 	  	 	0	 
	 Susan Schneider, M.D.
	  	 	0	 	  	 	0	 	  	 	322,300	 	  	 	0	 
	 Hope D’Oyley-Gay
	  	 	0	 	  	 	0	 	  	 	327,900	 	  	 	0	 
	 Stephen Potter
	  	 	47,133	 	  	 	8,750	 	  	 	662,149	 	  	 	0	 
	 Abraham Scaria
	  	 	0	 	  	 	0	 	  	 	344,500	 	  	 	0	 
	 William Aliski, MPA
	  	 	8,500	 	  	 	0	 	  	 	71,000	 	  	 	0	 
	 Yehia Hashad, M.D.
	  	 	0	 	  	 	0	 	  	 	39,000	 	  	 	0	 
	 Ed Hurwitz
	  	 	27,472	 	  	 	0	 	  	 	80,000	 	  	 	0	 
	 Scott Koenig, M.D., Ph.D.
	  	 	34,246	 	  	 	0	 	  	 	98,548	 	  	 	0	 
	 James Robinson
	  	 	0	 	  	 	0	 	  	 	25,000	 	  	 	0	 
	 James Rosen
	  	 	1,000	 	  	 	0	 	  	 	84,263	 	  	 	0	 
	 Anne VanLent
	  	 	0	 	  	 	0	 	  	 	80,000	 	  	 	0