### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] You are here: EPA Home Prevention, Pesticides & Toxic Substances Pollution Prevention & Toxics High Production Volume (HPV) Challenge High Production Volume Information System (HPVIS) Submission Report 

# High Production Volume Information System (HPVIS)

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# Submission Report

Submission Information

Submission ID : 25349350 Submission Name : 2,5-Furandione, dihydro-3-tetrapropenylAR Number :



## Chemical Information

CAS Number : 26544-38-7 Ninth Collective Index Name : 2,5-Furandione, dihydro-3-(tetrapropenyl)-



## Submitter Information

Submitter's Name : EPA

Address : City : Washington

State : DC

ZIP/Postal Code : Country : Type of Submitter : Company 

## Technical Point of Contact Information

Technical Point of Contact :
Title :
Phone Number :
Fax Number :
E-Mail Address : 

## Additional Technical Point of Contact Information

Technical Point of Contact :
Title :
Phone Number :
Fax Number :
E-Mail Address :



## Sponsor Information

Sponsor's Name : EPA

Address : City :
State :
ZIP/Postal Code : Country :
Phone Number :
Fax Number : Share

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] E-Mail Address : Type of Sponsor : Company 

## Technical Point of Contact Information

Technical Point of Contact :
Title :
Phone Number :
Fax Number :
E-Mail Address :



## Acute Toxicity to Aquatic Vertebrates

CAS Number : 26544-38-7

Sponsored Chemical Name : 2,5-Furandione, dihydro-3-(tetrapropenyl)-



### Test Substance - Acute Toxicity To Aquatic Vertebrates

Test Substance: (26544-38-7) 2,5-Furandione, dihydro-3-(tetrapropenyl)-

Test Substance Purity/Composition and Other Test Substance Comments:

Sponsored Chemical Result Type:

Test Substance Result Type:


### Method - Acute Toxicity To Aquatic Vertebrates

Year Study Performed:

Method/Guideline Followed:

Other Method/Guideline:

Deviations from Method/Guideline:

Species:

GLP:

Analytical Monitoring:

Test Type:

Test Vessel:

Water Media Type:

Test Concentrations:

Nominal and Measured Concentrations:

Exposure Period:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] Vehicle Used:

Vehicle Name:

Vehicle Amount and Units:

Alkalinity:

Dissolved Oxygen:

pH Value:

Test Temperature and Units:

Photo (Light/Dark):

Salinity:

TOC:

Water Hardness:

Method/Guideline Test Conditions Remarks:

Limit Test:



### Test Results - Acute Toxicity To Aquatic Vertebrates

NOEC Exposure Duration:

NOEC:

LOEC Exposure Duration:

LOEC:

NOELR Exposure Duration:

NOELR:

LOELR Exposure Duration:

LOELR:

LC/EC Mean Value : Exposure Duration Exposure Units LC/EC % Value Description Mean Value

or Lower Mean Value Upper Mean Value Units Effect Observed Basis for Concentration

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] Results Remarks:



### Reliability/Data Quality - Acute Toxicity To Aquatic Vertebrates

Reliability:

Reliability Remarks: As of February 2010, no data were available for this endpoint.

Key Study Sponsor Indicator:


### Reference - Acute Toxicity To Aquatic Vertebrates

Reference:



## Acute Toxicity to Aquatic Invertebrates

CAS Number : 26544-38-7

Sponsored Chemical Name : 2,5-Furandione, dihydro-3-(tetrapropenyl)-



### Test Substance - Acute Toxicity To Aquatic Invertebrates

Test Substance: (26544-38-7) 2,5-Furandione, dihydro-3-(tetrapropenyl)-

Test Substance Purity/Composition and Other Test Substance Comments:

Sponsored Chemical Result Type:

Test Substance Result Type:


### Method - Acute Toxicity To Aquatic Invertebrates

Year Study Performed:

Method/Guideline Followed:

Other Method/Guideline:

Deviations from Method/Guideline:

Species/In Vitro System:

GLP:

Analytical Monitoring:

Test Type:

Test Vessel:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] Water Media Type:

Test Concentrations:

Nominal and Measured Concentrations:

Exposure Period:

Vehicle Used:

Vehicle Name:

Vehicle Amount and Units:

Alkalinity:

Dissolved Oxygen:

pH Value:

Test Temperature and Units:

Photo (Light/Dark):

Salinity:

TOC:

Water Hardness:

Method/Guideline Test Conditions Remarks:

Limit Test:



### Test Results - Acute Toxicity To Aquatic Invertebrates

NOEC Exposure Duration:

NOEC:

LOEC Exposure Duration:

LOEC:

NOELR Exposure Duration:

NOELR:

LOELR Exposure Duration:

LOELR:

LC/EC Mean Value : Exposure Duration Exposure Units LC/EC % Value Description Mean Value

or Upper Mean Value Units Effect Observed Basis for Concentration

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] Lower Mean Value

Results Remarks:



### Reliability/Data Quality - Acute Toxicity To Aquatic Invertebrates

Reliability:

Reliability Remarks: As of February 2010, no data were available for this endpoint.

Key Study Sponsor Indicator:


### Reference - Acute Toxicity To Aquatic Invertebrates

Reference:



## Acute Toxicity to Aquatic Plants

CAS Number : 26544-38-7

Sponsored Chemical Name : 2,5-Furandione, dihydro-3-(tetrapropenyl)-



### Test Substance - Acute Toxicity To Aquatic Plants

Test Substance: (26544-38-7) 2,5-Furandione, dihydro-3-(tetrapropenyl)-

Test Substance Purity/Composition and Other Test Substance Comments:

Sponsored Chemical Result Type:

Test Substance Result Type:


### Method - Acute Toxicity To Aquatic Plants

Year Study Performed:

Method/Guideline Followed:

Other Method/Guideline:

Deviations from Method/Guideline:

Species:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] GLP:

Analytical Monitoring:

Test Type:

Test Vessel:

Water Media Type:

Test Concentrations:

Nominal and Measured Concentrations:

Exposure Period:

Vehicle Used:

Vehicle Name:

Vehicle Amount and Units:

Alkalinity:

Dissolved Oxygen:

pH Value:

Test Temperature and Units:

Photo (Light/Dark):

Salinity:

TOC:

Water Hardness:

Method/Guideline Test Conditions Remarks:

Limit Test:



### Test Results - Acute Toxicity To Aquatic Plants

NOEC Exposure Duration:

NOEC:

LOEC Exposure Duration:

LOEC:

NOELR Exposure Duration:

NOELR:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] LOELR Exposure Duration:

LOELR:

Effect : Exposure Duration Exposure Units Type % Value Description Mean Value

or Lower Mean Value Upper Mean Value Units Basis for Effect Basis for Concentration

Results Remarks:



### Reliability/Data Quality - Acute Toxicity To Aquatic Plants

Reliability:

Reliability Remarks: As of February 2010, no data were available for this endpoint.

Key Study Sponsor Indicator:


### Reference - Acute Toxicity To Aquatic Plants

Reference:



## Acute Toxicity

CAS Number : 26544-38-7

Sponsored Chemical Name

: 2,5-Furandione, dihydro-3-(tetrapropenyl)-



### Test Substance - Acute Toxicity

Test Substance: (26544-38-7) 2,5-Furandione, dihydro-3-(tetrapropenyl)-

Test Substance Purity/Composition and Other Test Substance Comments:

Sponsored Chemical Result Type: Measured



### Method - Acute Toxicity

Route of Administration: Oral

Type of Exposure: No Data

Species: Rat

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] Mammalian Strain: No Data

Gender: No Data

Number of Animals per Dose:

Dose:

Year Study Performed:

Method/Guideline Followed:

GLP:

Method/Guideline and Test Condition Remarks:


### Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LD 50 % = 2550 mg/kgbw

Number of Deaths ( Male ):

Number of Deaths ( Female ):

Number of Deaths ( Total ):

Results Remarks: LD50 = 2550 mg/kg

Conclusion:



### Reliability/Data Quality - Acute Toxicity

Reliability: 4 - Not Assignable

Reliability Remarks: Insufficient data were provided to assess study adequacy.

Key Study Sponsor Indicator:


### Reference - Acute Toxicity

Reference: Deichmann, W.B. and H.W. Gerarde. 1969. Toxicology of Drugs
and Chemicals. Academic Press, New York. Page 581.



## Acute Toxicity

CAS Number : 26544-38-7

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] Sponsored Chemical Name

: 2,5-Furandione, dihydro-3-(tetrapropenyl)-



### Test Substance - Acute Toxicity

Test Substance: (26544-38-7) 2,5-Furandione, dihydro-3-(tetrapropenyl)-

Test Substance Purity/Composition and Other Test Substance Comments:

Sponsored Chemical Result Type: Measured



### Method - Acute Toxicity

Route of Administration: Dermal

Type of Exposure: No Data

Species: Rabbit

Mammalian Strain: No Data

Gender: No Data

Number of Animals per Dose:

Dose:

Year Study Performed:

Method/Guideline Followed: No Data

GLP: No Data

Method/Guideline and Test Condition Remarks:


### Test Results - Acute Toxicity

Concentration (LC/LD) : LC/LD % Value Description Value/Lower Concentration Upper Concentration Units

LD 50 % = 6200 7500 mg/kgbw

Number of Deaths ( Male ):

Number of Deaths ( Female ):

Number of Deaths ( Total ):

Results Remarks: LD50 = 6200 mg/kg

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] Conclusion:



### Reliability/Data Quality - Acute Toxicity

Reliability: 4 - Not Assignable

Reliability Remarks: Insufficient data were provided to assess study adequacy.

Key Study Sponsor Indicator:


### Reference - Acute Toxicity

Reference: Deichmann, W.B. and H.W. Gerarde. 1969. Toxicology of Drugs
and Chemicals. Academic Press, New York. Page 581-582.



## Repeated-Dose Toxicity

CAS Number : 26544-38-7

Sponsored Chemical Name : 2,5-Furandione, dihydro-3-(tetrapropenyl)-



### Test Substance - Repeated-Dose Toxicity

Test Substance: (26544-38-7) 2,5-Furandione, dihydro-3-(tetrapropenyl)-

Test Substance Purity/Composition and Other Test Substance Comments:

Sponsored Chemical Result Type:


### Method - Repeated-Dose Toxicity

Route of Administration:

Type of Exposure:

Species:

Mammalian Strain:

Gender:

Number of Animals per Dose:

Dose:

Year Study Performed:

Method/Guideline Followed:

GLP:

Exposure Period:

Frequency of Treatment:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] Post-Exposure Period:

Method/Guideline and Test Condition Remarks:


### Test Results - Repeated-Dose Toxicity

Concentration (LOAEL/ LOAEC/ NOAEL/ NOAEC) : LOAEL/ LOAEC/ NOAEL/ NOAEC Population Value Description Value/Lower Concentration Upper Concentration Units

Results Remarks:

Conclusion:



### Reliability/Data Quality - Repeated-Dose Toxicity

Reliability:

Reliability Remarks: As of February 2010, no data were available for this endpoint.

Key Study Sponsor Indicator:


### Reference - Repeated-Dose Toxicity

Reference:



## Genetic Toxicity in vivo

CAS Number : 26544-38-7

Sponsored Chemical Name

: 2,5-Furandione, dihydro-3-(tetrapropenyl)-



### Test Substance - Genetic Toxicity in vivo

Test Substance: (26544-38-7) 2,5-Furandione, dihydro-3-(tetrapropenyl)-

Test Substance Purity/Composition and Other Test Substance Comments:

Sponsored Chemical Result Type:


### Method - Genetic Toxicity in vivo

Type of Study:

Type of Test:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] Route of Administration:

Type of Exposure:

Species:

Strain:

Gender:

Dose:

Year Study Performed:

Method/Guideline Followed:

GLP:

Duration of Treatment/ Exposure Period and Units:

Frequency of Treatment:

Positive, Negative, and Solvent Control Substance(s):

Number of Animals per Sex and Dose Group:

Method/Guideline and Test Condition Remarks:


### Test Results - Genetic Toxicity in vivo

Systemic Toxicity:

Genotoxic Effect:

Results Remarks:

Conclusion:



### Reliability/Data Quality - Genetic Toxicity in vivo

Reliability:

Reliability Remarks: As of February 2010, no data were available for this endpoint.

Key Study Sponsor Indicator:


### Reference - Genetic Toxicity in vivo

Reference:



## Genetic Toxicity in vitro

CAS Number : 26544-38-7

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] Sponsored Chemical Name

: 2,5-Furandione, dihydro-3-(tetrapropenyl)-



### Test Substance - Genetic Toxicity in vitro

Test Substance: (26544-38-7) 2,5-Furandione, dihydro-3-(tetrapropenyl)-

Test Substance Purity/Composition and Other Test Substance Comments:

Sponsored Chemical Result Type:


### Method - Genetic Toxicity in vitro

Type of Study:

Concentrations:

Year Study Performed:

Method/Guideline Followed:

GLP:

Postive, Negative, and Solvent Control Substance(s):

Method/Guideline and Test Condition Remarks:


### Test Results - Genetic Toxicity in vitro

Details on Cytogenetic Assay:

Statistics:

Effect : Species Other Species Strain Other Strain Metabolic Activation Genotoxic Effect Conclusion

Results Remarks:

Conclusion:



### Reliability/Data Quality - Genetic Toxicity in vitro

Reliability:

Reliability Remarks: As of February 2010, no data were available for this endpoint.

Key Study Sponsor

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] Indicator:


### Reference - Genetic Toxicity in vitro

Reference:



## Reproductive Toxicity

CAS Number : 26544-38-7

Sponsored Chemical Name : 2,5-Furandione, dihydro-3-(tetrapropenyl)-



### Test Substance - Reproductive Toxicity

Test Substance: (26544-38-7) 2,5-Furandione, dihydro-3-(tetrapropenyl)-

Test Substance Purity/Composition and Other Test Substance Comments:

Sponsored Chemical Result Type:


### Method - Reproductive Toxicity

Route of Administration:

Type of Exposure:

Species:

Mammalian Strain:

Gender:

Number of Animals per Dose:

Dose:

Year Study Performed:

Method/Guideline Followed:

GLP:

Exposure Period:

Frequency of Treatment:

Post-Exposure Period:

Method/Guideline and Test Condition Remarks:
Pre-Mating Exposure / Males:
Pre-Mating Exposure / Females:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] Test Results - Reproductive Toxicity

Concentration (LOAEL/ LOAEC/ NOAEL/ NOAEC) : LOAEL/ LOAEC/ NOAEL/ NOAEC Population Value Description Value/Lower Concentration Upper Concentration Units

Results:

Results Remarks:

Conclusion:



### Reliability/Data Quality - Reproductive Toxicity

Reliability:

Reliability Remarks: As of February 2010, no data were available for this endpoint.

Key Study Sponsor Indicator:


### Reference - Reproductive Toxicity

Reference:



## Developmental Toxicity/Teratogenicity

CAS Number : 26544-38-7

Sponsored Chemical Name : 2,5-Furandione, dihydro-3-(tetrapropenyl)-



### Test Substance - Developmental Toxicity/Teratogenicity

Test Substance: (26544-38-7) 2,5-Furandione, dihydro-3-(tetrapropenyl)-

Test Substance Purity/Composition and Other Test Substance Comments:

Sponsored Chemical Result Type: 

### Method - Developmental Toxicity/Teratogenicity

Route of Administration:

Type of Exposure:

Species:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

http://iaspub.epa.gov/hpvis/ServSubmissionPrint [6/15/2011 10:36:19 AM] Mammalian Strain:

Gender:

Number of Animals per Dose:

Dose:

Year Study Performed:

Method/Guideline Followed:

GLP:

Exposure Period:

Frequency of Treatment:

Post-Exposure Period:

Method/Guideline and Test Condition Remarks: 

### Test Results - Developmental Toxicity/Teratogenicity

Concentration (LOAEL/ LOAEC/ NOAEL/ NOAEC) : LOAEL/ LOAEC/ NOAEL/ NOAEC Population Value Description Value/Lower Concentration Upper Concentration Units

Results Remarks:

Conclusion:



### Reliability/Data Quality - Developmental Toxicity/Teratogenicity

Reliability:

Reliability Remarks: As of February 2010, no data were available for this endpoint.

Key Study Sponsor Indicator: 

### Reference - Developmental Toxicity/Teratogenicity

Reference:

### High Production Volume Information System (HPVIS) | High Production Volume (HPV) Challenge | OPPT | US EPA

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Last updated on Wednesday, June 15, 2011