Exhibit 10.10.3


 


THIRD AMENDMENT TO EXCLUSIVE PATENT
LICENSE AGREEMENT


 


This THIRD AMENDMENT TO EXCLUSIVE PATENT LICENSE AGREEMENT (“THIRD
AMENDMENT”) dated as of June 26, 2015 amends the Exclusive Patent License Agreement (“Agreement”) by and between
Duke University, a nonprofit educational and research institution organized under the laws of North Carolina (“DUKE”),
having its principal office at Durham, North Carolina 27708 and Humacyte, Inc., a corporation organized under the laws of North
Carolina (“HUMACYTE”), with its corporate headquarters and principal office at 7020 Kit Creek Road, Morrisville, NC
27560. All capitalized terms used herein and not otherwise defined shall have the meanings set forth in the Agreement.


 


BACKGROUND


 


WHEREAS, the Parties have determined that there is a typographical
error in reference to a specific patent application Serial Number included in the definition of PATENT RIGHTS incorrectly identified
as [***] and the Parties wish to correct that typographical error to [***].


 


NOW, THEREFORE, IN CONSIDERATION of the mutual covenants contained
herein, the Parties hereby agree as follows:


 


		1.	All terms and conditions of the Agreement and First Amendment not modified by this THIRD AMENDMENT shall continue in full force
and effect in accordance with their terms.



 


		2.	Section 1.13 PATENT RIGHTS. Section 1.13 of the Agreement is deleted and replaced with the following section:



 


1.13 “PATENT RIGHTS” means collectively
(a) United States PATENT APPLICATION [***], entitled [***] and (b) [***], entitled [***] (hereinafter, the patent applications
identified in the preceeding (a) and (b) may be referred to individually or collectively as “INITIAL PATENT APPLICATIONS”);
(c) all substitutes, continuations, continuations-in-part (but only to the extent that the subject matter of each such continuation-in-part
application is described in and enabled by the disclosure of the INITIAL PATENT APPLICATIONS), and divisionals of the foregoing
applications; (d) all foreign patent applications corresponding to the foregoing U.S. applications; (hereinafter, the patent applications
identified in the preceeding (a)—(d) may be referred to individually or collectively as “PATENT APPLICATIONS”);
and (e) all U.S. and foreign patents issued or issuing with respect to any of the foregoing applications and all extensions, renewals,
reissues thereof (“PATENTS”). Notwithstanding the foregoing, PATENT RIGHTS shall not include those patent applications
and/or patents that, during the term of this AGREEMENT, cease to be PATENT RIGHTS pursuant to COMPANY declining to financially
support the filing, prosecution, and/or maintenance of the subject patent applications and/or patents. Subject matter that is developed
after the date of this AGREEMENT that is novel and unobvious over subject matter described in the PATENT RIGHTS but that may fall
within the scope of the PATENT RIGHTS is not to be considered part of the PATENT RIGHTS. When any of the foregoing ceases to be
protected pursuant to an issued patent (or in the case of unpatented inventions, the pursuit of the filing or prosecution of a
patent application is abandoned or disallowed without the possibility of appeal or refiling), such rights will no longer be deemed
“PATENT RIGHTS.”


 






     


     


    

 


IN WITNESS WHEREOF, the Parties hereto have caused this THIRD
AMENDMENT to be executed by their duly authorized representatives, as set forth below.


  


	HUMACYTE, INC.	 	DUKE UNIVERSITY
	 	 	 	 	 
	By:	/s/ Paul Boyer	 	By:	/s/ Rose Ritts
	Name: 	Paul Boyer	 	Name: 	Rose Ritts
	Title:	CIO	 	Title:	Executive Dir, Licensing & Ventures



 


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