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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549





FORM 10-Q







|x | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ---------------------------------------------------------------------------------------

For the quarterly period ended June 30, 2009

or



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

Commission File Number: 0-21699





VIROPHARMA INCORPORATED

(Exact Name of Registrant as Specified in its Charter)







|                                                               |  |                                     
|-------------------------------------------------------------- |  | ------------------------------------
|Delaware                                                       |  | 23-2789550                          
|(State or other jurisdiction of incorporation or organization) |  | (I.R.S. Employer Identification No.)

730 Stockton Drive

Exton, Pennsylvania 19341

(Address of Principal Executive Offices and Zip
Code)

610-458-7300

(Registrants Telephone Number, Including Area Code)





Indicate by check mark whether the registrant
(1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports) and (2) has
been subject to such filing requirements for the past 90 days.    Yes  x    No   ̈

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be
submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such
files).    Yes   ̈    No   ̈

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer. See definition of accelerated filer and large accelerated filer in Rule 12b-2 of the Exchange Act.
(Check one):



|                        |  |   |  |                           |  |  
|----------------------- |  | - |  | ------------------------- |  | -
|Large Accelerated Filer |  | x |  | Accelerated Filer         |  |  ̈
|                        |  |   | 
|Non-accelerated filer   |  |  ̈ |  | Smaller Reporting Company |  |  ̈

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange
Act).    Yes   ̈    No  x

Number of shares outstanding of the issuers Common Stock, par value $.002 per share, as of July 24, 2009: 77,439,466 shares.









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##### Table of Contents

VIROPHARMA INCORPORATED

INDEX



|           |  |                                                                                                             |  |     
|---------- |  | ----------------------------------------------------------------------------------------------------------- |  | ----
|           |  |                                                                                                             |  | Page
|PART I     |  | FINANCIAL INFORMATION                                                                                       |  |     
|           |  |                                                                                                            
|Item 1.    |  | Financial Statements                                                                                        |  |     
|           |  |                                                                                                            
|           |  | Condensed Consolidated Balance Sheets (unaudited) at June 30, 2009 and December 31, 2008                    |  | 3   
|           |  |                                                                                                            
|           |  | Consolidated Statements of Operations (unaudited) for the three and six months ended June 30, 2009 and 2008 |  | 4   
|           |  |                                                                                                            
|           |  | Consolidated Statements of Stockholders Equity (unaudited) for the six months ended June 30, 2009 and 2008 |  | 5   
|           |  |                                                                                                            
|           |  | Consolidated Statements of Cash Flows (unaudited) for the six months ended June 30, 2009 and 2008           |  | 6   
|           |  |                                                                                                            
|           |  | Notes to the Consolidated Financial Statements (unaudited)                                                  |  | 7   
|           |  |                                                                                                            
|Item 2.    |  | Managements Discussion and Analysis of Financial Condition and Results of Operations                       |  | 19  
|           |  |                                                                                                            
|Item 3.    |  | Quantitative and Qualitative Disclosures About Market Risk                                                  |  | 32  
|           |  |                                                                                                            
|Item 4.    |  | Controls and Procedures                                                                                     |  | 33  
|           |  |                                                                                                            
|PART II    |  | OTHER INFORMATION                                                                                           |  | 34  
|           |  |                                                                                                            
|Item 1A.   |  | Risk Factors                                                                                                |  | 34  
|           |  |                                                                                                            
|Item 4.    |  | Submission of Matters to a Vote of Security Holders                                                         |  | 35  
|           |  |                                                                                                            
|Item 6.    |  | Exhibits                                                                                                    |  | 36  
|           | 
|SIGNATURES |  | 37                                                                                                         



2



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##### Table of Contents

ViroPharma Incorporated

Condensed Consolidated Balance Sheet

(unaudited)



|                                                                                                                                                                              |  |              |           |   |                  |   |           |  
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------ | --------- | - | ---------------- | - | --------- | -
|(in thousands, except share and per share data)                                                                                                                               |  | June 30,2009 |           |   | December 31,2008 |  
|Assets                                                                                                                                                                        |  |              |           |   |                  |   |           |  
|Current assets:                                                                                                                                                               |  |              |           |   |                  |   |           |  
|Cash and cash equivalents                                                                                                                                                     |  | $            | 267,171   |   |                  | $ | 275,839   |  
|Accounts receivable, net                                                                                                                                                      |  |              | 33,040    |   |                  |   | 15,058    |  
|Inventory                                                                                                                                                                     |  |              | 29,454    |   |                  |   | 27,168    |  
|Prepaid expenses and other current assets                                                                                                                                     |  |              | 6,481     |   |                  |   | 5,120     |  
|Income taxes receivable                                                                                                                                                       |  |              | 7,010     |   |                  |   | 6,867     |  
|Property and building held for sale                                                                                                                                           |  |              | 6,734     |   |                  |   | 6,734     |  
|Deferred income taxes                                                                                                                                                         |  |              | 14,650    |   |                  |   | 24,094    |  
|                                                                                                                                                                              |  |              |           |   |                  |   |           |  
|Total current assets                                                                                                                                                          |  |              | 364,540   |   |                  |   | 360,880   |  
|Intangible assets, net                                                                                                                                                        |  |              | 632,012   |   |                  |   | 639,693   |  
|Property, equipment and building improvements, net                                                                                                                            |  |              | 7,180     |   |                  |   | 6,853     |  
|Goodwill                                                                                                                                                                      |  |              |          |   |                  |   | 65,099    |  
|Debt issue costs, net                                                                                                                                                         |  |              | 2,978     |   |                  |   | 3,892     |  
|Other assets                                                                                                                                                                  |  |              | 9,415     |   |                  |   | 9,712     |  
|                                                                                                                                                                              |  |              |           |   |                  |   |           |  
|Total assets                                                                                                                                                                  |  | $            | 1,016,125 |   |                  | $ | 1,086,129 |  
|                                                                                                                                                                              |  |              |           |   |                  |   |           |  
|                                                                                                                                                                              |  |             
|Liabilities and Stockholders Equity                                                                                                                                          |  |              |           |   |                  |   |           |  
|Current liabilities:                                                                                                                                                          |  |              |           |   |                  |   |           |  
|Accounts payable                                                                                                                                                              |  | $            | 7,781     |   |                  | $ | 5,719     |  
|Due to partners                                                                                                                                                               |  |              | 192       |   |                  |   | 1,279     |  
|Accrued expenses and other current liabilities                                                                                                                                |  |              | 27,884    |   |                  |   | 35,587    |  
|Income tax payable                                                                                                                                                            |  |              | 959       |   |                  |   | 882       |  
|                                                                                                                                                                              |  |              |           |   |                  |   |           |  
|Total current liabilities                                                                                                                                                     |  |              | 36,816    |   |                  |   | 43,467    |  
|Non-current income tax payable and other non-current liabilities                                                                                                              |  |              | 2,778     |   |                  |   | 4,071     |  
|Deferred tax liability                                                                                                                                                        |  |              | 129,632   |   |                  |   | 128,254   |  
|Long-term debt                                                                                                                                                                |  |              | 135,254   |   |                  |   | 161,003   |  
|                                                                                                                                                                              |  |              |           |   |                  |   |           |  
|Total liabilities                                                                                                                                                             |  |              | 304,480   |   |                  |   | 336,795   |  
|                                                                                                                                                                              |  |              |           |   |                  |   |           |  
|                                                                                                                                                                              |  |             
|Commitments and Contingencies                                                                                                                                                 |  |              |           |   |                  |   |           |  
|                                                                                                                                                                              |  |             
|Stockholders equity:                                                                                                                                                         |  |              |           |   |                  |   |           |  
|Preferred stock, par value $0.001 per share. 5,000,000 shares authorized; Series A convertible participating preferred stock; no shares issued
and outstanding                |  |              |          |   |                  |   |          |  
|Series A junior participating preferred stock, par value $0.001 per share. 200,000 shares designated; no shares issued and
outstanding                                        |  |              |          |   |                  |   |          |  
|Common stock, par value $0.002 per share. 175,000,000 shares authorized; issued and outstanding 77,439,466 shares at June 30, 2009 and
77,397,621 shares at December 31, 2008 |  |              | 156       |   |                  |   | 156       |  
|Additional paid-in capital                                                                                                                                                    |  |              | 695,767   |   |                  |   | 690,502   |  
|Accumulated other comprehensive loss                                                                                                                                          |  |              | (446      | ) |                  |   | (655      | )
|Retained earnings                                                                                                                                                             |  |              | 16,168    |   |                  |   | 59,331    |  
|                                                                                                                                                                              |  |              |           |   |                  |   |           |  
|Total stockholders equity                                                                                                                                                    |  |              | 711,645   |   |                  |   | 749,334   |  
|                                                                                                                                                                              |  |              |           |   |                  |   |           |  
|Total liabilities and stockholders equity                                                                                                                                    |  | $            | 1,016,125 |   |                  | $ | 1,086,129 |  
|                                                                                                                                                                              |  |              |           |   |                  |   |           |  

See accompanying notes to unaudited consolidated financial statements.



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ViroPharma Incorporated

Consolidated Statements of Operations

(unaudited)



|                                                         |  |                            |        |   |                          |   |        |      |  |   |         |   |  |   |         |  
|-------------------------------------------------------- |  | -------------------------- | ------ | - | ------------------------ | - | ------ | ---- |  | - | ------- | - |  | - | ------- | -
|                                                         |  | Three months endedJune 30, |        |   | Six months endedJune 30, |  
|(in thousands, except per share data)                    |  | 2009                       |        |   | 2008                     |   |        | 2009 |  |   | 2008    |  
|                                                         |  |                            |        |  
|Revenues:                                                |  |                            |        |   |                          |   |        |      |  |   |         |   |  |   |         |  
|Net product sales                                        |  | $                          | 81,873 |   |                          | $ | 65,437 |      |  | $ | 142,063 |   |  | $ | 116,374 |  
|                                                         |  |                            |        |  
|Costs and Expenses:                                      |  |                            |        |   |                          |   |        |      |  |   |         |   |  |   |         |  
|Cost of sales (excluding amortization of product rights) |  |                            | 14,121 |   |                          |   | 2,386  |      |  |   | 18,049  |   |  |   | 4,304   |  
|Research and development                                 |  |                            | 12,467 |   |                          |   | 14,584 |      |  |   | 32,151  |   |  |   | 28,999  |  
|Selling, general and administrative                      |  |                            | 23,612 |   |                          |   | 16,605 |      |  |   | 47,990  |   |  |   | 30,004  |  
|Intangible amortization                                  |  |                            | 7,424  |   |                          |   | 2,145  |      |  |   | 14,681  |   |  |   | 3,833   |  
|Goodwill impairment                                      |  |                            |       |   |                          |   |       |      |  |   | 65,099  |   |  |   |        |  
|                                                         |  |                            |        |   |                          |   |        |      |  |   |         |   |  |   |         |  
|Total costs and expenses                                 |  |                            | 57,624 |   |                          |   | 35,720 |      |  |   | 177,970 |   |  |   | 67,140  |  
|                                                         |  |                            |        |   |                          |   |        |      |  |   |         |   |  |   |         |  
|Operating income (loss)                                  |  |                            | 24,249 |   |                          |   | 29,717 |      |  |   | (35,907 | ) |  |   | 49,234  |  
|                                                         |  |                            |        |  
|Other Income (Expense):                                  |  |                            |        |   |                          |   |        |      |  |   |         |   |  |   |         |  
|Interest income                                          |  |                            | 105    |   |                          |   | 4,067  |      |  |   | 250     |   |  |   | 10,378  |  
|Interest expense                                         |  |                            | (2,677 | ) |                          |   | (3,218 | )    |  |   | (5,986  | ) |  |   | (6,346  | )
|Gain on long-term debt repurchase                        |  |                            |       |   |                          |   |       |      |  |   | 9,079   |   |  |   |        |  
|                                                         |  |                            |        |   |                          |   |        |      |  |   |         |   |  |   |         |  
|Income (loss) before income tax expense                  |  |                            | 21,677 |   |                          |   | 30,566 |      |  |   | (32,564 | ) |  |   | 53,266  |  
|                                                         |  |                            |        |  
|Income tax expense                                       |  |                            | 5,625  |   |                          |   | 7,783  |      |  |   | 10,599  |   |  |   | 14,098  |  
|                                                         |  |                            |        |   |                          |   |        |      |  |   |         |   |  |   |         |  
|Net income (loss)                                        |  |                            | 16,052 |   |                          |   | 22,783 |      |  |   | (43,163 | ) |  |   | 39,168  |  
|                                                         |  |                            |        |   |                          |   |        |      |  |   |         |   |  |   |         |  
|                                                         |  |                            |        |  
|Net income (loss) per share:                             |  |                            |        |   |                          |   |        |      |  |   |         |   |  |   |         |  
|Basic                                                    |  | $                          | 0.21   |   |                          | $ | 0.33   |      |  | $ | (0.56   | ) |  | $ | 0.56    |  
|Diluted                                                  |  | $                          | 0.20   |   |                          | $ | 0.29   |      |  | $ | (0.56   | ) |  | $ | 0.51    |  
|                                                         |  |                            |        |  
|Shares used in computing net income per share:           |  |                            |        |   |                          |   |        |      |  |   |         |   |  |   |         |  
|Basic                                                    |  |                            | 77,406 |   |                          |   | 69,947 |      |  |   | 77,406  |   |  |   | 69,936  |  
|Diluted                                                  |  |                            | 88,996 |   |                          |   | 84,349 |      |  |   | 77,406  |   |  |   | 84,314  |  

See accompanying notes to unaudited consolidated financial statements.



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ViroPharma Incorporated

Consolidated Statements of Stockholders Equity

(unaudited)



|                                                                                     |  |                 |  |              |   |                 |        |        |             |                          |  |   |                        |   |  |                  |      |   |                          |   |         |   |  |   |         |  
|------------------------------------------------------------------------------------ |  | --------------- |  | ------------ | - | --------------- | ------ | ------ | ----------- | ------------------------ |  | - | ---------------------- | - |  | ---------------- | ---- | - | ------------------------ | - | ------- | - |  | - | ------- | -
|                                                                                     |  | Preferred Stock |  | Common Stock |   |                 |        |        | Accumulated |                          |  |   |                        |   |  |                 
|(in thousands)                                                                       |  | Numberof shares |  | Amount       |   | Numberof shares |        | Amount |             | Additionalpaid-incapital |  |   | othercomprehensiveloss |   |  | RetainedEarnings |      |   | Totalstockholdersequity |  
|Balance, December 31, 2008, as adjusted for the adoption of FSP APB 14-1, see Note 2 |  |                |  | $            |  |                 | 77,398 |        | $           | 156                      |  | $ | 690,502                |   |  | $                | (655 | ) |                          | $ | 59,331  |   |  | $ | 749,334 |  
|Exercise of common stock options                                                     |  |                |  |              |  |                 | 10     |        |             |                         |  |   | 12                     |   |  |                  |     |   |                          |   |        |   |  |   | 12      |  
|Employee stock purchase plan                                                         |  |                |  |              |  |                 | 31     |        |             |                         |  |   | 164                    |   |  |                  |     |   |                          |   |        |   |  |   | 164     |  
|Share-based compensation                                                             |  |                |  |              |  |                 |       |        |             |                         |  |   | 6,779                  |   |  |                  |     |   |                          |   |        |   |  |   | 6,779   |  
|Cumulative translation adjustment                                                    |  |                |  |              |  |                 |       |        |             |                         |  |   |                       |   |  |                  | 209  |   |                          |   |        |   |  |   | 209     |  
|Termination of call spread options, net                                              |  |                |  |              |  |                 |       |        |             |                         |  |   | 274                    |   |  |                  |     |   |                          |   |        |   |  |   | 274     |  
|Repurchase of conversion options on long term debt                                   |  |                |  |              |  |                 |       |        |             |                         |  |   | (1,964                 | ) |  |                  |     |   |                          |   |        |   |  |   | (1,964  | )
|Net income (loss)                                                                    |  |                |  |              |  |                 |       |        |             |                         |  |   |                       |   |  |                  |     |   |                          |   | (43,163 | ) |  |   | (43,163 | )
|                                                                                     |  |                 |  |              |   |                 |        |        |             |                          |  |   |                        |   |  |                  |      |   |                          |   |         |   |  |   |         |  
|                                                                                     |  |                 |  |              |   |                 |        |       
|Balance, June 30, 2009                                                               |  |                |  | $            |  |                 | 77,439 |        | $           | 156                      |  | $ | 695,767                |   |  | $                | (446 | ) |                          | $ | 16,168  |   |  | $ | 711,645 |  
|                                                                                     |  |                 |  |              |   |                 |        |        |             |                          |  |   |                        |   |  |                  |      |   |                          |   |         |   |  |   |         |  

See accompanying notes to unaudited consolidated financial statements.



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ViroPharma Incorporated

Consolidated Statements of Cash Flows

(unaudited)



|                                                                                         |  |                          |         |   |      |   |         |  
|---------------------------------------------------------------------------------------- |  | ------------------------ | ------- | - | ---- | - | ------- | -
|                                                                                         |  | Six months endedJune 30, |        
|(in thousands)                                                                           |  | 2009                     |         |   | 2008 |  
|                                                                                         |  |                         
|Cash flows from operating activities:                                                    |  |                          |         |   |      |   |         |  
|Net (loss) income                                                                        |  | $                        | (43,163 | ) |      | $ | 39,168  |  
|Adjustments to reconcile net (loss) income to net cash provided by operating activities: |  |                          |         |   |      |   |         |  
|Non-cash share-based compensation expense                                                |  |                          | 6,779   |   |      |   | 4,086   |  
|Non-cash interest expense                                                                |  |                          | 3,737   |   |      |   | 3,866   |  
|Gain on long-term debt repurchase                                                        |  |                          | (9,079  | ) |      |   |        |  
|Non-cash goodwill impairment                                                             |  |                          | 65,099  |   |      |   |        |  
|Deferred tax provision                                                                   |  |                          | 7,719   |   |      |   | 10,145  |  
|Depreciation and amortization expense                                                    |  |                          | 15,444  |   |      |   | 4,494   |  
|Changes in assets and liabilities:                                                       |  |                          |         |   |      |   |         |  
|Accounts receivable                                                                      |  |                          | (17,982 | ) |      |   | (9,541  | )
|Inventory                                                                                |  |                          | (2,286  | ) |      |   | 28      |  
|Interest receivable                                                                      |  |                          |        |   |      |   | 3,132   |  
|Prepaid expenses and other current assets                                                |  |                          | (1,361  | ) |      |   | 1,673   |  
|Income taxes receivable/payable                                                          |  |                          | (66     | ) |      |   | (3,313  | )
|Other assets                                                                             |  |                          | 1,885   |   |      |   | (559    | )
|Due to partners                                                                          |  |                          | (1,087  | ) |      |   |        |  
|Accounts payable                                                                         |  |                          | 2,062   |   |      |   | (208    | )
|Accrued expenses and other current liabilities                                           |  |                          | (11,833 | ) |      |   | (2,684  | )
|Non-current income tax payable and other non-current liabilities                         |  |                          |        |   |      |   | 40      |  
|                                                                                         |  |                          |         |   |      |   |         |  
|Net cash provided by operating activities                                                |  |                          | 15,868  |   |      |   | 50,327  |  
|                                                                                         |  |                         
|Cash flows from investing activities:                                                    |  |                          |         |   |      |   |         |  
|Purchase of Vancocin assets                                                              |  |                          | (2,987  | ) |      |   | (2,078  | )
|Purchase of property, plant and equipment                                                |  |                          | (1,058  | ) |      |   | (622    | )
|Maturities of short-term investments                                                     |  |                          |        |   |      |   | 269,002 |  
|                                                                                         |  |                          |         |   |      |   |         |  
|Net cash (used in) provided by investing activities                                      |  |                          | (4,045  | ) |      |   | 266,302 |  
|                                                                                         |  |                         
|Cash flows from financing activities:                                                    |  |                          |         |   |      |   |         |  
|Long-term debt repurchase                                                                |  |                          | (21,150 | ) |      |   |        |  
|Termination of call spread options, net                                                  |  |                          | 274     |   |      |   |        |  
|Net proceeds from issuance of common stock                                               |  |                          | 176     |   |      |   | 224     |  
|                                                                                         |  |                          |         |   |      |   |         |  
|Net cash (used in) provided by financing activities                                      |  |                          | (20,700 | ) |      |   | 224     |  
|                                                                                         |  |                         
|Effect of exchange rate changes on cash                                                  |  |                          | 209     |   |      |   | (10     | )
|                                                                                         |  |                          |         |   |      |   |         |  
|Net (decrease) increase in cash and cash equivalents                                     |  |                          | (8,668  | ) |      |   | 316,843 |  
|                                                                                         |  |                         
|Cash and cash equivalents at beginning of period                                         |  |                          | 275,839 |   |      |   | 179,691 |  
|                                                                                         |  |                          |         |   |      |   |         |  
|Cash and cash equivalents at end of period                                               |  | $                        | 267,171 |   |      | $ | 496,534 |  
|                                                                                         |  |                          |         |   |      |   |         |  

See accompanying notes to unaudited consolidated financial statements.



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##### Table of Contents

ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements

Note 1. Organization and Business Activities

ViroPharma Incorporated and subsidiaries (ViroPharma or the
Company) is a global biopharmaceutical company dedicated to the development and commercialization of products that address serious diseases, with a focus on products used by physician specialists or in hospital settings. The Company
intends to grow through sales of its marketed products, CinryzeTMand Vancocin,
through continued development of its product pipeline and through potential acquisition or licensing of products or acquisition of companies. ViroPharma has two marketed products and three development programs.

We market and sell Cinryze, which has been approved by the FDA for the prophylactic treatment of hereditary angioedema (HAE). Cinryze is a C1 inhibitor therapy for
routine prophylaxis against HAE, also known as C1 inhibitor deficiency, a rare, severely debilitating, life-threatening genetic disorder. Cinryze was obtained in October 2008, when we completed our acquisition of Lev Pharmaceuticals, Inc.
(Lev), a biopharmaceutical company focused on developing and commercializing therapeutic products for the treatment of inflammatory diseases. In December 2008, we submitted a supplemental Biologics Application (sBLA) for Cinryze as a treatment for
acute attacks of HAE based on a re-analysis and resubmission of data from a pivotal Phase 3 acute treatment study of Cinryze and interim data from an ongoing open label acute study of the drug. On June 4, 2009, we announced that we received a
Complete Response letter from the U.S. Food and Drug Administration (FDA) related to our supplemental Biologics License Application (sBLA) for Cinryze(TM) (C1 esterase inhibitor [human]) as a treatment for acute attacks of hereditary angioedema
(HAE). The FDA has requested an additional clinical study, due to their opinion that the placebo controlled study submitted in support of the sBLA lacked robustness. In the Complete Response letter, the FDA cited no safety concerns related to acute
treatment with Cinryze in the clinical studies. We are currently evaluating our path forward for the acute indication of HAE. In addition, the FDA approved the patient labeling for Cinryze to include self-administration for routine prophylaxis once
patients are properly trained by their healthcare provider. We are currently evaluating with our partner Sanquin, the feasibility of additional territories, indications and/or other formulations for Cinryze. Part of this plan is obtaining Orphan
Drug designation for Europe.

The Company also markets and sells Vancocin HCl capsules, the oral capsule formulation of vancomycin hydrochloride, in the
U.S. and its territories. Vancocin is a potent antibiotic approved by the U.S. Food and Drug Administration, or FDA, to treat antibiotic-associated pseudomembranous colitis caused by Clostridium difficileinfection (CDI), or C.
difficile, and enterocolitis caused by Staphylococcus aureus, including methicillin-resistant strains.

ViroPharma is developing two product
candidates, maribavir for the prevention and treatment of cytomegalovirus, or CMV disease; and non-toxigenic strains of C. difficile (NTCD) for the treatment and prevention of CDI. On February 9, 2009, we announced that our Phase 3 trial
evaluating maribavir used as prophylaxis in allogeneic stem cell, or bone marrow, transplant (SCT) patients did not achieve its primary endpoint. In the primary analysis, there was no statistically significant difference between maribavir and
placebo in reducing the rate of CMV disease. Additionally, on February 13, 2009, we announced that enrollment in our Phase 3 trial evaluating maribavir in liver transplant patients was discontinued and that all patients on study drug were moved
to the current standard of care. We discontinued dosing patients with maribavir in clinical trials and are evaluating our maribavir program in light of the Phase 3 clinical trial results.

Basis of Presentation

The consolidated financial information at
June 30, 2009 and for the three and six months ended June 30, 2009 and 2008, is unaudited but includes all adjustments (consisting only of normal recurring adjustments) which, in the opinion of management, are necessary to state fairly the
consolidated financial information set forth therein in accordance with accounting principles generally accepted in the United States of America. The interim results are not necessarily indicative of results to be expected for the full fiscal year.
These unaudited consolidated financial statements should be read in conjunction with the audited consolidated financial statements for the year ended December 31, 2008 included in the Companys Annual Report on Form 10-K filed with the
Securities and Exchange Commission. We have evaluated all subsequent events through July 29, 2009, the date the financial statements were issued.

Adoption of Standards

In May 2009, the Financial Accounting Standards Board (FASB) released Statement of Financial Accounting Standards
(SFAS) No. 165, Subsequent Events (SFAS 165), which establishes the accounting for and disclosure of events that occur after the balance sheet date but before financial statements are issued or are available to be issued. It requires the
disclosure of the date through which an entity has evaluated subsequent events and the basis for that date, that is, whether that date represents the date the financial statements were issued or were available to be issued. See Basis of
Presentation for the related disclosures. The adoption of SFAS 165 did not have a material impact on our financial statements.



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements



In April 2009, the FASB released FASB Staff Position (FSP) 107-1 and Accounting Principles Board (APB) Opinion
No. 28-1, Interim Disclosures about Fair Value of Financial Instruments (FSP SFAS 107-1 and APB 28-1). This pronouncement amends FASB Statement No. 107, Disclosures about Fair Values of Financial Instruments, to require
disclosures about fair value of financial instruments in interim financial statements as well as in annual financial statements. FSP SFAS 107-1 and APB 28-1 also amends APB Opinion No. 28, Interim Financial Reporting, to require
those disclosures in summarized financial information at interim financial statements. The Company adopted FSP SFAS 107-1 and APB 28-1 on June 30, 2009 and has provided the necessary additional disclosures.

In April 2009, the FASB released FSP SFAS 157-4, Determining Whether a Market Is Not Active and a Transaction Is Not Distressed (SFAS 157-4). This
pronouncement provides additional guidance for estimating fair value in accordance with SFAS No. 157, Fair Value Measurements,when the volume and level of activity for the asset or liability have significantly decreased. The Company
adopted SFAS 157-4 in the second quarter of 2009 with no impact on the Companys financial position, cash flows, or disclosures.

In April
2009, the FASB issued FSP SFAS 115-2 and SFAS 124-2, Recognition and Presentation of Other-Than-Temporary Impairments. This pronouncement provides guidance in determining whether impairments in debt securities are other than temporary,
and modifies the presentation and disclosures surrounding such instruments. This Staff Position is effective for interim periods ending after June 15, 2009. The Company adopted the provisions of this Proposed Staff Position during
second quarter 2009, with no impact on the Companys financial position, cash flows, or disclosures.

In May 2008, the FASB issued FASB Staff
Position (FSP) No. APB 14-1, Accounting for Convertible Debt Instruments That May Be Settled in Cash upon Conversion (Including Partial Cash Settlement) (FSP APB 14-1). FSP APB 14-1 requires the issuer of convertible debt instruments
with cash settlement features to separately account for the liability and equity components of the instrument. The debt is recognized at the present value of its cash flows discounted using the issuers nonconvertible debt borrowing rate. The
equity component is recognized as the difference between the proceeds from the issuance of the note and the fair value of the liability. FSP APB 14-1also requires an accretion of the resultant debt discount over the expected life of the debt. The
transition guidance requires retrospective application to all periods presented, and does not grandfather existing instruments. The Company adopted FSP APB 14-1 on January 1, 2009 and retrospectively applied this change in accounting to all
prior periods presented for which we had applicable outstanding convertible debt, as required by this new standard which is discussed further in Note 2.

In December 2007, the FASB issued SFAS No. 141R, Business Combinations (SFAS 141R),which will significantly change the accounting for business combinations. SFAS 141R is effective for fiscal years beginning after
December 15, 2008. The Company adopted SFAS 141R on January 1, 2009 and will apply the guidance of the Statement to business combinations completed after January 1, 2009 and to any tax adjustments of previous acquisitions.

In April 2009, the FASB issued FSP FAS 141(R)-1, Accounting for Assets Acquired and Liabilities Assumed in a Business Combination That Arise from
Contingencies. This pronouncement amends and clarifies FASB Statement No. 141 (revised 2007), Business Combinations, to address application issues on initial recognition and measurement, subsequent measurement and accounting, and
disclosure of assets and liabilities arising from contingencies in a business combination. This FSP applies to all assets acquired and liabilities assumed in a business combination that arise from contingencies that would be within the scope of
Statement 5 if not acquired or assumed in a business combination, except for assets or liabilities arising from contingencies that are subject to specific guidance in Statement 141(R). This FSP shall be effective for assets or liabilities arising
from contingencies in business combinations for which the acquisition date is on or after the beginning of the first annual reporting period beginning on or after December 15, 2008. The Company adopted FSP FAS 141(R)-1 and will apply the
guidance of the Statement to assets and liabilities assumed in a business combinations completed after January 1, 2009.

In December 2007, the FASB
issued SFAS No. 160, Noncontrolling Interests in Consolidated Financial Statements  An Amendment of ARB No. 51(SFAS 160),which establishes new accounting and reporting standards for the noncontrolling interest in a
subsidiary and for the deconsolidation of a subsidiary. The Company adopted SFAS 160 on January 1, 2009 with no impact on operating results or financial position.

In March 2008, the FASB issued SFAS No. 161, Disclosures about Derivative Instruments and Hedging Activities  an amendment of FASB Statement No. 133 (SFAS 161), which changes the disclosure
requirements for derivative instruments and hedging activities. Entities are required to provide enhanced disclosures about (a) how and why an entity uses derivative instruments, (b) how derivative instruments and related hedged items are
accounted for under SFAS No. 133, Accounting for Derivative Instruments and Hedging Activities (SFAS 133) and its related interpretations, and (c) how derivative instruments and related hedged items affect an entitys financial
position, financial performance, and cash flows. The Company adopted SFAS 161 on January 1, 2009 and such disclosures are included here in.



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements



In November 2007, the FASB issued Emerging Issues Task Force (EITF) No. 07-1 Accounting for Collaborative
Arrangements Related to the Development and Commercialization of Intellectual Property (EITF 07-1) which is focused on how the parties to a collaborative agreement should disclose costs incurred and revenue generated on sales to third parties,
how sharing payments pursuant to a collaboration agreement should be presented in the income statement and certain related disclosure questions. The Company adopted EITF 07-1 January 1, 2009 with no impact on operating results or financial
position. As previously disclosed in our Form 10-K, the Company has a collaborative agreement with Wyeth Pharmaceuticals for research and development activities. Primarily all activities under this agreement ended during 2008. The expenses for these
activities in both periods presented were recorded against research and development expense.

In June 2008, the FASB issued FSP
EITF No. 03-6-1, Determining Whether Instruments Granted in Share-Based Payment Transactions Are Participating Securities (FSP EITP 03-6-1). Under the FSP EITF 03-6-1, unvested share-based payment awards that contain rights to
receive nonforfeitable dividends (whether paid or unpaid) are participating securities, and should be included in the two-class method of computing EPS. This Company adopted this FSP EITF 03-6-1 on January 1, 2009. The Company does not have
share-based payment awards that contain rights to nonforfeitable dividends, thus this FSP EITF 03-6-1 does not impact the Companys consolidated financial statements.

In June 2008, the FASB ratified EITF Issue No. 07-5, Determining Whether an Instrument (or Embedded Feature) Is Indexed to an Entitys Own Stock(EITF 07-5).EITF 07-5 provides that an entity
should use a two step approach to evaluate whether an equity-linked financial instrument (or embedded feature) is indexed to its own stock, including evaluating the instruments contingent exercise and settlement provisions. The Company adopted
EITF 07-5 on January 1, 2009 with no impact on operating results or financial position.

Reclassification

Certain prior year amounts have been reclassified to conform to the current year presentation.

Note 2. Accounting Changes Adopted - FASB Staff Position (FSP) No. APB 14-1

The Company adopted FSP APB
14-1 as of January 1, 2009 and retrospectively applied this change in accounting to all prior periods presented for which we had applicable outstanding convertible debt, as required by this new standard. In accordance with Statement of
Financial Accounting Standards No. 154, Accounting Changes and Error Correction, all prior periods presented herein have been adjusted to apply the new method retrospectively. Under this new method of accounting, the debt and equity
components of our convertible debt securities are bifurcated and accounted for separately based on the value and related interest rate of a non-convertible debt security with the same terms. The fair value of a non-convertible debt instrument at the
original issuance date was determined to be $148.1 million. The equity (conversion options) component of our convertible debt securities is included in Additional paid-in capital on our Consolidated Balance Sheet and, accordingly, the initial
carrying value of the debt securities was reduced by $101.9 million. Our net income for financial reporting purposes was reduced by recognizing the accretion of the reduced carrying values of our convertible debt securities to their face amount
of $250.0 million as additional non-cash interest expense. The adoption of FSP APB 14-1 has resulted in a reduction in the carrying value of our convertible debt by approximately $89.0 million as of December 31, 2008. In addition, the
adoption of FSP APB 14-1 reduced our deferred debt issuance costs as we were required to allocate the amount related to the conversion option to equity.

Due to the retrospective adoption of FSP APB 14-1, we had to adjust our previously recognized deferred tax asset related to our convertible debt. The bifurcation of the convertible notes caused us to establish a deferred tax liability
at issuance. This change in prior period deferred tax assets impacted the deferred tax assets ultimately available to be recognized in the purchase accounting for our acquisition of Lev in October 2008. Accordingly the goodwill resulting from
the transaction increased $35.2 million to $65.1 million in our adjusted December 31, 2008 balance sheet.



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements



Condensed Consolidated Balance Sheet

(unaudited)



|                                                |  |                         |           |                          |   |          
|----------------------------------------------- |  | ----------------------- | --------- | ------------------------ | - | ---------
|(in thousands, except share and per share data) |  | RevisedDecember 31,2008 |           | ReportedDecember 31,2008
|                                                |  |                        
|Assets                                          |  |                         |           |                          |   |          
|Current assets:                                 |  |                         |           |                          |   |          
|Total current assets                            |  | $                       | 360,880   |                          | $ | 360,880  
|Goodwill                                        |  |                         | 65,099    |                          |   | 29,936   
|Debt issue costs, net                           |  |                         | 3,892     |                          |   | 6,610    
|                                                |  |                         |           |                          |   |          
|Total assets                                    |  | $                       | 1,086,129 |                          | $ | 1,053,684
|                                                |  |                         |           |                          |   |          
|                                                |  |                        
|Liabilities and Stockholders Equity            |  |                         |           |                          |   |          
|Current liabilities:                            |  |                         |           |                          |   |          
|Accrued expenses and other current liabilities  |  | $                       | 35,587    |                          | $ | 35,650   
|                                                |  |                         |           |                          |   |          
|Total current liabilities                       |  |                         | 43,467    |                          |   | 43,467   
|Deferred tax liability                          |  |                         | 128,254   |                          |   | 95,121   
|Long-term debt                                  |  |                         | 161,003   |                          |   | 250,000  
|                                                |  |                         |           |                          |   |          
|Total liabilities                               |  |                         | 336,795   |                          |   | 392,660  
|                                                |  |                         |           |                          |   |          
|                                                |  |                        
|Commitments and Contingencies                   |  |                         |           |                          |   |          
|                                                |  |                        
|Additional paid-in capital                      |  |                         | 690,502   |                          |   | 595,287  
|Retained earnings                               |  |                         | 59,331    |                          |   | 66,236   
|                                                |  |                         |           |                          |   |          
|Total stockholders equity                      |  |                         | 749,334   |                          |   | 661,024  
|                                                |  |                         |           |                          |   |          
|Total liabilities and stockholders equity      |  | $                       | 1,086,129 |                          | $ | 1,053,684
|                                                |  |                         |           |                          |   |          

Consolidated Statements of Operations

(unaudited)



|                                               |             |                            |        |              |                          |   |             |   |  |              |        |   |  |   |        |  
|---------------------------------------------- | ----------- | -------------------------- | ------ | ------------ | ------------------------ | - | ----------- | - |  | ------------ | ------ | - |  | - | ------ | -
|(in thousands, except per share data)          |             | Three Months EndedJune 30, |        |              | Six Months EndedJune 30, |  
|                                               | Revised2008 |                            |        | Reported2008 |                          |   | Revised2008 |   |  | Reported2008 |       
|                                               |             |                            |        |             
|Operating income                               |             | $                          | 29,717 |              |                          | $ | 29,717      |   |  | $            | 49,234 |   |  | $ | 49,234 |  
|                                               |             |                            |        |             
|Other Income (Expense):                        |             |                            |        |              |                          |   |             |   |  |              |        |   |  |   |        |  
|Interest income                                |             |                            | 4,067  |              |                          |   | 4,067       |   |  |              | 10,378 |   |  |   | 10,378 |  
|Interest expense                               |             |                            | (3,218 | )            |                          |   | (1,450      | ) |  |              | (6,346 | ) |  |   | (2,869 | )
|                                               |             |                            |        |              |                          |   |             |   |  |              |        |   |  |   |        |  
|Income before income tax expense               |             |                            | 30,566 |              |                          |   | 32,334      |   |  |              | 53,266 |   |  |   | 56,743 |  
|                                               |             |                            |        |             
|Income tax expense                             |             |                            | 7,783  |              |                          |   | 8,264       |   |  |              | 14,098 |   |  |   | 15,223 |  
|                                               |             |                            |        |              |                          |   |             |   |  |              |        |   |  |   |        |  
|Net income                                     |             | $                          | 22,783 |              |                          | $ | 24,070      |   |  | $            | 39,168 |   |  | $ | 41,520 |  
|                                               |             |                            |        |              |                          |   |             |   |  |              |        |   |  |   |        |  
|                                               |             |                            |        |             
|Net income per share:                          |             |                            |        |              |                          |   |             |   |  |              |        |   |  |   |        |  
|Basic                                          |             | $                          | 0.33   |              |                          | $ | 0.34        |   |  | $            | 0.56   |   |  | $ | 0.59   |  
|Diluted                                        |             | $                          | 0.29   |              |                          | $ | 0.30        |   |  | $            | 0.51   |   |  | $ | 0.51   |  
|                                               |             |                            |        |             
|Shares used in computing net income per share: |             |                            |        |              |                          |   |             |   |  |              |        |   |  |   |        |  
|Basic                                          |             |                            | 69,947 |              |                          |   | 69,947      |   |  |              | 69,936 |   |  |   | 69,936 |  
|Diluted                                        |             |                            | 84,349 |              |                          |   | 84,349      |   |  |              | 84,314 |   |  |   | 84,314 |  



Note 3. Inventory

Inventory is related to Cinryze and Vancocin and is stated at the lower of cost or market using the first-in first-out method. The following represents the components of
the inventory at June 30, 2009 and December 31, 2008:



|                |  |              |        |                  |   |       
|--------------- |  | ------------ | ------ | ---------------- | - | ------
|(in thousands)  |  | June 30,2009 |        | December 31,2008
|Raw Materials   |  | $            | 12,156 |                  | $ | 11,861
|Work In Process |  |              | 9,307  |                  |   | 10,802
|Finished Goods  |  |              | 7,991  |                  |   | 4,505 
|                |  |              |        |                  |   |       
|Total           |  | $            | 29,454 |                  | $ | 27,168
|                |  |              |        |                  |   |       



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements



Note 4. Intangible Assets

The following represents the balance of the intangible assets at June 30, 2009:



|                       |  |                       |         |                         |   |                      |  |   |        
|---------------------- |  | --------------------- | ------- | ----------------------- | - | -------------------- |  | - | -------
|(in thousands)         |  | GrossIntangibleAssets |         | AccumulatedAmortization |   | Net IntangibleAssets
|Cinryze Product rights |  | $                     | 521,000 |                         | $ | 14,454               |  | $ | 506,546
|Vancocin Intangibles   |  |                       | 154,099 |                         |   | 28,633               |  |   | 125,466
|                       |  |                       |         |                         |   |                      |  |   |        
|Total                  |  | $                     | 675,099 |                         | $ | 43,087               |  | $ | 632,012
|                       |  |                       |         |                         |   |                      |  |   |        

The following represents the balance of the intangible assets at December 31, 2008:



|                       |  |                       |         |                         |   |                      |  |   |        
|---------------------- |  | --------------------- | ------- | ----------------------- | - | -------------------- |  | - | -------
|(in thousands)         |  | GrossIntangibleAssets |         | AccumulatedAmortization |   | Net IntangibleAssets
|Cinryze Product rights |  | $                     | 521,000 |                         | $ | 4,034                |  | $ | 516,966
|Vancocin Intangibles   |  |                       | 147,099 |                         |   | 24,372               |  |   | 122,727
|                       |  |                       |         |                         |   |                      |  |   |        
|Total                  |  | $                     | 668,099 |                         | $ | 28,406               |  | $ | 639,693
|                       |  |                       |         |                         |   |                      |  |   |        

In March 2006, the Company learned that the FDAs Office of Generic Drugs (OGD) had changed its approach
regarding the conditions that must be met in order for a generic drug applicant to request a waiver of in-vivo bioequivalence testing for copies of Vancocin. Since this change in approach is, in accordance with SFAS No. 144 Accounting for
the Impairment or Disposal of Long-Lived Assets(SFAS 144), a triggering event and potentially impacts the recoverability or useful life of the Vancocin-related intangible assets, the Company assessed the Vancocin-related intangible assets for
potential impairment or change in useful life. While the Company is opposing this attempt by the OGD, the outcome of the OGDs attempts to relax the standards for proving generic bioequivalence to Vancocin cannot be reasonably determined and
the impact of this change on market share and net sales is uncertain. However, the Company determined that no impairment charge was appropriate at that time as management believes the undiscounted cash flows, which consider some level of generic
impact, will be sufficient to recover the carrying value of the asset and there has been no change to fair value.

In December 2008, FDA changed OGDs
2006 bioequivalence recommendation by issuing draft guidance for establishing bioequivalence to Vancocin which would require generic products that have the same inactive ingredients in the same quantities as Vancocin (Q1 and Q2 the same)
to demonstrate bioequivalence through comparative in vitro dissolution testing. Under this latest proposed method, any generic product that is not Q1 and Q2 the same as Vancocin would need to conduct an in vivo study with clinical endpoints to
demonstrate bioequivalence with Vancocin. The FDA will convene a meeting of its Advisory Committee for Pharmaceutical Science and Clinical Pharmacology to discuss bioequivalence recommendations for oral vancomycin hydrochloride capsule drug
products. The meeting is scheduled for August 4, 2009. We have submitted briefing materials to the Advisory Committee for its consideration on the issues presented by OGDs bioequivalence recommendation, and we expect to present these
issues at the meeting. However, if FDAs proposed bioequivalence method for Vancocin becomes effective, the time period in which a generic competitor may enter the market would be reduced and multiple generics may enter the market, which
would materially impact our operating results, cash flows and possibly intangible asset valuations. This could also result in a reduction to the useful life of the Vancocin-related intangible assets. Management currently believes there are no
indicators that would require a change in useful life as management believes that Vancocin will continue to be utilized along with generics that may enter the market.

A reduction in the useful life, as well as the timing and number of generics, will impact our cash flow assumptions and estimate of fair value, perhaps to a level that could result in an impairment charge. The Company
will continue to monitor the actions of the OGD and consider the effects of our opposition actions and the announcements by generic competitors or other adverse events for additional impairment indicators and will reevaluate the expected cash flows
and fair value of our Vancocin-related assets at such time.



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements



The Company is obligated to pay Eli Lilly and Company (Lilly) additional purchase price consideration based on net
sales of Vancocin within a calendar year. The additional purchase price consideration is determined by the annual net sales of Vancocin, is paid quarterly and is due each year through 2011. The Company accounts for these additional payments as
additional purchase price in accordance with SFAS No. 141, Business Combinations, which requires that the additional purchase price consideration is recorded as an increase to the intangible assets of Vancocin, is allocated over the
asset classifications described above and is amortized over the remaining estimated useful life of the intangible assets. In addition, at the time of recording the additional intangible assets, a cumulative adjustment is recorded to accumulated
intangible amortization, in addition to ordinary amortization expense, in order to reflect amortization as if the additional purchase price had been paid in November 2004.

As of June 30, 2009, we have paid an aggregate of $3.0 million to Lilly in additional purchase price consideration, as our net sales of Vancocin surpassed the maximum obligation level of $65 million in 2008,
2007, 2006 and 2005. The $33.1 million paid to Lilly was based upon 35% of $20 million in 2008, 35% of $17 million in 2007, 35% of $19 million in 2006 and 50% of $21 million in 2005. The Company is obligated to pay Lilly additional amounts based on
35% of annual net sales between $45 and $65 million of Vancocin during 2009 through 2011.

Based on net sales in the second quarter of 2009, $4.0 million
is due to Lilly on net sales of Vancocin above the net sales levels reflected above.

Note 5. Goodwill Impairment

During the first quarter of 2009 and as of March 31, 2009, the market capitalization of the Company fell below the carrying value of the Companys net assets
due to the release of our results of our Phase 3 clinical trial evaluating maribavir used as prophylaxis in allogeneic stem cell transplant patients and our decision to discontinue dosing in our Phase 3 trial of maribavir in solid organ (liver)
transplant patients. In accordance with SFAS 142, the fact that our market capitalization fell below our carrying value required us to test for impairment of our goodwill and other intangible assets. We conducted this analysis at March 31, 2009
and concluded that our goodwill was impaired due to our market capitalization being below the carrying value of our net assets for an extended period of time. We incurred a $65.1 million charge in the first quarter related to this goodwill
impairment.

Note 6. Property, Equipment and Building Improvements

At June 30, 2009 and December 31, 2008, we had $6.7 million of Property and Building classified as held for sale in accordance with SFAS 144 related to our previous corporate headquarters. During
2008, we incurred a $2.3 million impairment related to this building.

In March 2008, we entered into a lease for a new corporate headquarters located in
Exton, Pennsylvania. Additionally, in May 2008, we entered into a lease for office space in Maidenhead, UK for our European operations.

The useful life
for the major categories of property and equipment are 30 years for the building, 3 to 5 years for computers and equipment and 15 years for building improvements.

Note 7. Long-Term Debt

Long-term debt as of June 30, 2009 and December 31, 2008 is summarized in the following table:



|                         |  |              |         |                          |   |        
|------------------------ |  | ------------ | ------- | ------------------------ | - | -------
|(in thousands)           |  | June 30,2009 |         | AdjustedDecember 31,2008
|                         |  |             
|Senior convertible notes |  | $            | 135,254 |                          | $ | 161,003
|                         |  |              |         |                          |   |        
|                         |  |             
|less: current portion    |  |              |        |                          |   |       
|                         |  |              |         |                          |   |        
|                         |  |             
|Total debt principal     |  | $            | 135,254 |                          | $ | 161,003
|                         |  |              |         |                          |   |        



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements



On March 26, 2007, the Company issued $250.0 million of 2% senior convertible notes due March 2017 (the
senior convertible notes) in a public offering. The $250.0 million includes an issuance pursuant to the underwriters exercise of an overallotment in the amount of $25.0 million that was closed concurrently on March 26,
2007. Net proceeds from the issuance of the senior convertible notes were $241.8 million. The senior convertible notes are unsecured unsubordinated obligations and rank equally with any other unsecured and unsubordinated
indebtedness. The senior convertible notes bear interest at a rate of 2% per annum, payable semi-annually in arrears on March 15 and September 15 of each year commencing on September 15, 2007.

The Company adopted FSP APB 14-1 as of January 1, 2009 and retrospectively applied this change in accounting to all prior periods presented for which we had
outstanding convertible debt, as required by this new standard. Under this new method of accounting, the debt and equity components of our convertible debt securities are bifurcated and accounted for separately. Under this new method of
accounting, the convertible debt securities will recognize interest expense at effective rates of 8.0% as they are accreted to par value. See Note 2 for further explanation.

On March 24, 2009 the Company repurchased, in a privately negotiated transaction, $45.0 million in principal amount of the Companys senior convertible notes due March 2017 for total consideration of
approximately $21.2 million. The repurchase represented 18% of our then outstanding debt and was executed at a price equal to 47% of par value. Following these repurchases, senior convertible notes representing $205.0 million of principal debt
are outstanding with a carrying value of $133.7 million as of March 31, 2009. The senior convertible note repurchase will reduce the companys cash and non-cash interest expense for the balance of fiscal 2009 by approximately $0.7 million
and $1.2 million respectively. Additionally, in negotiated transactions, the Company sold approximately 2.38 million call options for approximately $1.8 million and repurchased approximately 2.38 million warrants for approximately $1.5
million which terminated the call options and warrants that were previously entered into by the Company in March 2007. The Company recognized a $9.1 million gain in the first quarter of 2009 as a result of this debt extinguishment. For tax
purposes, the gain qualifies for deferral until 2014 in accordance with the provisions of the American Recovery and Reinvestment Act.

As of June 30,
2009, the Company has accrued $1.2 million in interest payable to holders of the senior convertible notes. Debt issuance costs of $4.8 million have been capitalized and are being amortized over the term of the senior convertible notes, with the
balance to be amortized as of June 30, 2009 being $3.0 million.

The senior convertible notes are convertible into shares of the Companys common
stock at an initial conversion price of $18.87 per share. The senior convertible notes may only be converted: (i) anytime after December 15, 2016; (ii) during the five business-day period after any five consecutive trading day
period (the measurement period) in which the price per note for each trading day of that measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion rate on each such day;
(iii) during any calendar quarter (and only during such quarter) after the calendar quarter ending June 30, 2007, if the last reported sale price of our common stock for 20 or more trading days in a period of 30 consecutive trading days
ending on the last trading day of the immediately preceding calendar quarter exceeds 130% of the applicable conversion price in effect on the last trading day of the immediately preceding calendar quarter; or (iv) upon the occurrence of
specified corporate events. Upon conversion, holders of the senior convertible notes will receive shares of common stock, subject to ViroPharmas option to irrevocably elect to settle all future conversions in cash up to the principal amount of
the senior convertible notes, and shares for any excess. We can irrevocably elect this option at any time on or prior to the 35th scheduled trading day prior to the maturity date of the senior convertible notes. The senior convertible
notes may be required to be repaid on the occurrence of certain fundamental changes, as defined in the senior convertible notes. As of June 30, 2009, the fair value of the principal of the $205.0 million convertible senior notes
outstanding was approximately $112.4 million, based on the level 2 valuation hierarchy under SFAS No.157Fair Value Measurements (SFAS 157).

Concurrent with the issuance of the senior convertible notes, the Company entered into privately-negotiated transactions, comprised of purchased call options and warrants sold, to reduce the potential dilution of our common stock upon
conversion of the senior convertible notes. The transactions, taken together, have the effect of increasing the initial conversion price to $24.92 per share. The net cost of the transactions was $23.3 million.

The call options allowed ViroPharma to receive up to approximately 13.25 million shares of its common stock at $18.87 per share from the call option holders, equal
to the number of shares of common stock that ViroPharma would issue to the holders of the senior convertible notes upon conversion. These call options will terminate upon the earlier of the maturity dates of the related senior convertible notes
or the first day all of the related senior convertible notes are no longer outstanding due to conversion or otherwise. Concurrently, the Company sold warrants to the warrant holders to receive shares of its common stock at an exercise price of
$24.92 per share. These warrants expire ratably over a 60-day trading period beginning on June 13, 2017 and will be net-share settled.



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements



The purchased call options are expected to reduce the potential dilution upon conversion of the senior convertible
notes in the event that the market value per share of ViroPharma common stock at the time of exercise is greater than $18.87, which corresponds to the initial conversion price of the senior convertible notes, but less than $24.92 (the warrant
exercise price). The warrant exercise price is 75.0% higher than the price per share of $14.24 of the Companys stock on the pricing date. If the market price per share of ViroPharma common stock at the time of conversion of any senior
convertible notes is above the strike price of the purchased call options ($18.87), the purchased call options will entitle the Company to receive from the counterparties in the aggregate the same number of shares of our common stock as the Company
would be required to issue to the holder of the converted senior convertible notes. Additionally, if the market price of ViroPharma common stock at the time of exercise of the sold warrants exceeds the strike price of the sold warrants ($24.92), the
Company will owe the counterparties an aggregate of approximately 13.25 million shares of ViroPharma common stock. If we have insufficient shares of common stock available for settlement of the warrants, we may issue shares of a newly
created series of preferred stock in lieu of our obligation to deliver common stock. Any such preferred stock would be convertible into 10% more shares of our common stock than the amount of common stock we would otherwise have been obligated to
deliver under the warrants. The Company was entitled to receive approximately 10.87 million shares of its common stock at $18.87 from the call option holders and if the market price of ViroPharma common stock at the time of exercise of the sold
warrants exceeds the strike price of the sold warrants ($24.92), will owe the counterparties an aggregate of approximately 10.87 million shares of ViroPharma common stock.

The purchased call options and sold warrants are separate transactions entered into by the Company with the counterparties, are not part of the terms of the senior convertible notes, and will not affect the
holders rights under the senior convertible notes. Holders of the senior convertible notes will not have any rights with respect to the purchased call options or the sold warrants. The purchased call options and sold warrants meet the
definition of derivatives under SFAS No. 133, Accounting for Derivative Instruments and Hedging Activities. These instruments have been determined to be indexed to the Companys own stock (in accordance with the guidance
of EITF Issue No. 01-6, The Meaning of Indexed to a Companys Own Stock) and have been recorded in stockholders equity in the Companys Consolidated Balance Sheet (as determined under EITF Issue No. 07-5,
Determining Whether an Instrument (or Embedded Feature) Is Indexed to an Entitys Own Stock). As long as the instruments are classified in stockholders equity they are not subject to the mark to market provisions of SFAS
No. 133.

Note 8. Share-based Compensation

In
accordance with Statement of Financial Accounting Standards No. 123 (revised 2004), Share-Based Payment (SFAS 123R), the Company recorded share-based compensation expense as follows:



|                                    |      |                            |       |                          |      |       |      |   |       |  |   |      
|----------------------------------- | ---- | -------------------------- | ----- | ------------------------ | ---- | ----- | ---- | - | ----- |  | - | -----
|(in thousands)                      |      | Three months endedJune 30, |       | Six months endedJune 30,
|                                    | 2009 |                            | 2008  |                          | 2009 |       | 2008
|Research and development            |      | $                          | 961   |                          | $    | 664   |      | $ | 1,929 |  | $ | 1,335
|Selling, general and administrative |      |                            | 1,522 |                          |      | 1,349 |      |   | 4,850 |  |   | 2,751
|                                    |      |                            |       |                          |      |       |      |   |       |  |   |      
|Total                               |      | $                          | 2,483 |                          | $    | 2,013 |      | $ | 6,779 |  | $ | 4,086
|                                    |      |                            |       |                          |      |       |      |   |       |  |   |      

Our SFAS 123R expense increased $0.5 million and $2.7 million, for the three and six months ended June 30,
2009, respectively, as compared to the same period in the prior year due to increased headcount.

Employee Stock Option Plans

The Company currently has three option plans in place: a 1995 Stock Option and Restricted Share Plan (1995 Plan), a 2001 Equity Incentive Plan (2001
Plan) and a 2005 Stock Option and Restricted Share Plan (2005 Plan) (collectively, the Plans). On May 23, 2008, the 2005 Plan was amended and an additional 5,000,000 shares of common stock was reserved for issuance
upon the exercise of stock options or the grant of restricted shares or restricted share units. This amendment was approved by stockholders at the Companys Annual Meeting of Stockholders.

The following table lists the balances available by Plan at June 30, 2009:



|                                            |  |            |   |  |            |   |  |            |   |  |             |  
|------------------------------------------- |  | ---------- | - |  | ---------- | - |  | ---------- | - |  | ----------- | -
|                                            |  | 1995 Plan  |   |  | 2001 Plan  |   |  | 2005 Plan  |   |  | Combined    |  
|Number of shares authorized                 |  | 4,500,000  |   |  | 500,000    |   |  | 7,850,000  |   |  | 12,850,000  |  
|Number of options granted since inception   |  | (6,997,515 | ) |  | (1,255,472 | ) |  | (5,404,862 | ) |  | (13,657,849 | )
|Number of options cancelled since inception |  | 2,979,058  |   |  | 790,493    |   |  | 373,029    |   |  | 4,142,580   |  
|Number of shares expired                    |  | (480,293   | ) |  | (1,375     | ) |  |           |   |  | (481,668    | )
|                                            |  |            |   |  |            |   |  |            |   |  |             |  
|Number of shares available for grant        |  | 1,250      |   |  | 33,646     |   |  | 2,818,167  |   |  | 2,853,063   |  
|                                            |  |            |   |  |            |   |  |            |   |  |             |  



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements



The Company issued stock options in the first six-months of 2009. The weighted average fair value of each option
grant was estimated at $6.79 per share using the Black-Scholes option-pricing model using the following assumptions:



|                                         |  |                
|---------------------------------------- |  | ---------------
|Expected dividend yield                  |  | -              
|Range of risk free interest rate         |  | 1.55% - 3.18%  
|Weighted-average volatility              |  | 77.26%         
|Range of volatility                      |  | 73.80% - 79.92%
|Range of expected option life (in years) |  | 5.50 6.25     

The Company has 7,728,535 option grants outstanding at June 30, 2009 with exercise prices ranging from $0.99
per share to $38.70 per share and a weighted average remaining contractual life of 7.07 years. The following table lists the outstanding and exercisable option grants as of June 30, 2009:



|            |  |                   |  |                                |       |                                                  |      |                                        |   |      
|----------- |  | ----------------- |  | ------------------------------ | ----- | ------------------------------------------------ | ---- | -------------------------------------- | - | -----
|            |  | Number of options |  | Weighted averageexercise price |       | Weighted averageremainingcontractual term(years) |      | Aggregate intrinsicvalue(in
thousands)
|Outstanding |  | 7,728,535         |  | $                              | 10.74 |                                                  | 7.07 |                                        | $ | 4,729
|Exercisable |  | 4,072,043         |  | $                              | 10.51 |                                                  | 5.43 |                                        | $ | 4,685

As of June 30, 2009, there was $23.2 million of total unrecognized compensation cost related to unvested
share-based payments (including share options) granted under the Plans. That cost is expected to be recognized over a weighted-average period of 2.72 years.

Employee Stock Purchase Plan

The Company has an employee stock purchase plan. Under this plan, 32,558 shares were sold to employees during
the first six months of 2009. During the year ended December 31, 2008, 24,478 shares were sold to employees. As of June 30, 2009 there are approximately 516,217 shares available for issuance under this plan.

Under this plan, there are two plan periods: January 1 through June 30 (Plan Period One) and July 1 through
December 31 (Plan Period Two). For Plan Period One in 2009, the fair value of approximately $124,700 was estimated using the Type B model provided by SFAS 123R, with a risk free interest rate of 0.28%, volatility of 76.1% and an
expected option life of 0.5 years. This fair value is being amortized over the six month period ending June 30, 2009.

Note 9. Income Tax Expense

Our income tax expense was $5.6 million and $7.8 million for the quarters ended June 30, 2009 and 2008, respectively and $10.6 million and $14.1
million for the six months ended June 30, 2009 and 2008, respectively. Our income tax expense includes federal, state and foreign income taxes at statutory rates and the effects of various permanent differences. The income tax expense in the
first six months of 2009 reflects the full impact of our gain on the repurchase of a portion of our convertible notes. In addition, our full year tax expense will include the effect of our current estimate of the impact of the orphan drug credit for
maribavir. The decrease in the 2009 expense as compared to 2008 is primarily due to the decrease in taxable income from 2008.



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##### Table of Contents

ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements



During the six months ended June 30, 2009, we paid approximately $1.2 million as a result of the IRS audit of
the Companys 2006 federal income tax return and results in a reduction of our taxes payable liability. The Company also has various state returns currently under examination. The final outcome of these reviews are not yet determinable.

Included in other assets is approximately $1.6 million of non-current deferred tax assets related to our foreign operations.

Note 10. Comprehensive Income

The following table reconciles net
income (loss) to comprehensive income (loss) for the three and six months ended June 30, 2009 and 2008:



|                                                  |      |                            |        |  |                          |        |   |  |      |         |   |  |   |        |  
|------------------------------------------------- | ---- | -------------------------- | ------ |  | ------------------------ | ------ | - |  | ---- | ------- | - |  | - | ------ | -
|(in thousands)                                    |      | Three months endedJune 30, |        |  | Six months endedJune 30, |       
|                                                  | 2009 |                            | 2008   |  |                          | 2009   |   |  | 2008 |        
|Net income (loss)                                 |      | $                          | 16,052 |  | $                        | 22,783 |   |  | $    | (43,163 | ) |  | $ | 39,168 |  
|Other comprehensive:                              |      |                            |        |  |                          |        |   |  |      |         |   |  |   |        |  
|Unrealized gains on available for sale securities |      |                            |       |  |                          | (588   | ) |  |      |        |   |  |   | 707    |  
|Currency translation adjustments                  |      |                            | 24     |  |                          | 67     |   |  |      | 209     |   |  |   | (10    | )
|                                                  |      |                            |        |  |                          |        |   |  |      |         |   |  |   |        |  
|Comprehensive income (loss)                       |      | $                          | 16,076 |  | $                        | 22,262 |   |  | $    | (42,954 | ) |  | $ | 39,865 |  
|                                                  |      |                            |        |  |                          |        |   |  |      |         |   |  |   |        |  

The unrealized gains are reported net of federal and state income taxes.

Note 11. Earnings (Loss) per share



|                                                                    |      |                            |        |                          |      |        |  |      |         |   |  |   |       
|------------------------------------------------------------------- | ---- | -------------------------- | ------ | ------------------------ | ---- | ------ |  | ---- | ------- | - |  | - | ------
|(in thousands, except per share data)                               |      | Three months endedJune 30, |        | Six months endedJune 30,
|                                                                    | 2009 |                            | 2008   |                          | 2009 |        |  | 2008
|Basic Earnings (Loss) Per Share                                     |      |                            |        |                          |      |        |  |      |         |   |  |   |       
|Net income (loss)                                                   |      | $                          | 16,052 |                          | $    | 22,783 |  | $    | (43,163 | ) |  | $ | 39,168
|Common stock outstanding (weighted average)                         |      |                            | 77,406 |                          |      | 69,947 |  |      | 77,406  |   |  |   | 69,936
|                                                                    |      |                            |        |                          |      |        |  |      |         |   |  |   |       
|Basic net income (loss) per share                                   |      | $                          | 0.21   |                          | $    | 0.33   |  | $    | (0.56   | ) |  | $ | 0.56  
|                                                                    |      |                            |        |                          |      |        |  |      |         |   |  |   |       
|                                                                    |      |                            |        |                         
|Diluted Earnings (Loss) Per Share                                   |      |                            |        |                          |      |        |  |      |         |   |  |   |       
|Net income (loss)                                                   |      | $                          | 16,052 |                          | $    | 22,783 |  | $    | (43,163 | ) |  | $ | 39,168
|Add interest expense on senior convertible notes, net of income tax |      |                            | 1,652  |                          |      | 1,997  |  |      |        |   |  |   | 3,938 
|                                                                    |      |                            |        |                          |      |        |  |      |         |   |  |   |       
|Diluted net income (loss)                                           |      | $                          | 17,704 |                          | $    | 24,780 |  | $    | (43,163 | ) |  | $ | 43,106
|                                                                    |      |                            |        |                         
|Common stock outstanding (weighted average)                         |      |                            | 77,406 |                          |      | 69,947 |  |      | 77,406  |   |  |   | 69,936
|Add shares from senior convertible notes                            |      |                            | 10,864 |                          |      | 13,248 |  |      |        |   |  |   | 13,248
|Add in-the-money stock options                                    |      |                            | 726    |                          |      | 1,154  |  |      |        |   |  |   | 1,130 
|                                                                    |      |                            |        |                          |      |        |  |      |         |   |  |   |       
|Common stock assuming conversion and stock option exercises         |      |                            | 88,996 |                          |      | 84,349 |  |      | 77,406  |   |  |   | 84,314
|                                                                    |      |                            |        |                          |      |        |  |      |         |   |  |   |       
|Diluted net income (loss) per share                                 |      | $                          | 0.20   |                          | $    | 0.29   |  | $    | (0.56   | ) |  | $ | 0.51  
|                                                                    |      |                            |        |                          |      |        |  |      |         |   |  |   |       

The following common shares that are associated with stock options were excluded from the calculations as their
effect would be anti-dilutive:



|                                     |      |                            |      |                          |      |        |      |      
|------------------------------------ | ---- | -------------------------- | ---- | ------------------------ | ---- | ------ | ---- | -----
|(in thousands)                       |      | Three months endedJune 30, |      | Six months endedJune 30,
|                                     | 2009 |                            | 2008 |                          | 2009 |        | 2008
|Out-of-the-money stock options     |      | 5,721                      |      | 4,912                    |      | 5,591  |      | 4,935
|Shares from senior convertible notes |      |                           |      |                         |      | 10,864 |      |     
|In-the-money stock options         |      |                           |      |                         |      | 826    |      |     



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##### Table of Contents

ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements



Note 12. Fair Value Measurement

Valuation Hierarchy - SFAS 157 establishes a valuation hierarchy for disclosure of the inputs to valuation used to measure fair value. This hierarchy prioritizes the inputs into three broad levels as follows. Level 1
inputs are quoted prices (unadjusted) in active markets for identical assets or liabilities. Level 2 inputs are quoted prices for similar assets and liabilities in active markets or inputs that are observable for the asset or liability, either
directly or indirectly through market corroboration, for substantially the full term of the financial instrument. Level 3 inputs are unobservable inputs based on our own assumptions used to measure assets and liabilities at fair value. A financial
asset or liabilitys classification within the hierarchy is determined based on the lowest level input that is significant to the fair value measurement.

The following table provides the assets and liabilities carried at fair value measured on a recurring basis as of June 30, 2009:



|                          |  |                                     |         |                                                |   |           |  |           |   |  |   |  
|------------------------- |  | ----------------------------------- | ------- | ---------------------------------------------- | - | --------- |  | --------- | - |  | - | -
|                          |  |                                     |         | Fair Value Measurements at June 30, 2009 Using
|(in millions of dollars)  |  | Total CarryingValue atJune 30, 2009 |         | (Level 1)                                      |   | (Level 2) |  | (Level 3)
|Cash and cash equivalents |  | $                                   | 267,171 |                                                | $ | 267,171   |  | $         |  |  | $ | 
|                          |  |                                     |         |                                                |   |           |  |           |   |  |   |  
|Total                     |  | $                                   | 267,171 |                                                | $ | 267,171   |  |           |  |  |   | 
|                          |  |                                     |         |                                                |   |           |  |           |   |  |   |  

Valuation Techniques-Cash and cash equivalents are measured at fair value using quoted market
prices and are classified within Level 1 of the valuation hierarchy. There were no changes in valuation techniques during the quarter ended June 30, 2009.

We adopted FSP FAS 107-1 and APB Opinion 28-1 in the second quarter of 2009. The guidance requires quarterly fair value disclosures for financial instruments rather than annual disclosure. We believe that the fair
values of our current assets and current liabilities approximate their reported carrying amounts.

Note 13. Lev Pharmaceuticals, Inc. Acquisition

In October 2008, we acquired all the outstanding common stock of Lev Pharmaceuticals, Inc. (Lev). Lev was a biopharmaceutical company focused on developing
and commercializing therapeutic products for the treatment of inflammatory diseases. The terms of the merger agreement provided for the conversion of each share of Lev common stock into upfront consideration of $453.1 million, or $2.75 per Lev
share, comprised of $2.25 per share in cash and $0.50 per share in ViroPharma common stock, and contingent consideration (CVRs) of up to $1.00 per share which may be paid on achievement of certain regulatory and commercial milestones. The
first CVR payment of $0.50 per share (or $87.5 million) would become payable when either (i) Cinryze is approved by the FDA for acute treatment of HAE and the FDA grants orphan exclusivity for Cinryze encompassing the acute treatment of HAE to
the exclusion of all other human C1 inhibitor products or, (ii) orphan exclusivity for the acute treatment of HAE has not become effective for any third partys human C1 inhibitor product by October 21, 2010. The second CVR payment of
$0.50 per share ($87.5 million) would become payable when Cinryze reaches at least $600.0 million in cumulative net product sales within 10 years of closing of the acquisition.

The value of the CVRs has not been included in the total cost of the acquisition, as the payment of these amounts is not reasonably assured at this time. Should any of the contingently issued payments be made,
that value would be added to the purchase price. Additionally, as part of the purchase price allocation, we released the valuation allowance for ViroPharmas existing deferred tax assets that management believes are more likely than not to be
realized as a result of the acquisition. This allocation of purchase price to Levs assets acquired and liabilities assumed is preliminary and may change when final purchase price allocation is completed within one year.

The retrospective adoption of FSP APB 14-1 eliminated the book and tax basis difference and related deferred tax asset which resulted in an adjustment to goodwill of
$35.2 million for the recasted December 31, 2008 balance sheet.



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements



The results of Levs operations have been included in the consolidated financial statements beginning
October 21, 2008.

Note 14. Collaborations

In
December 1999, we entered into a collaboration and license agreement with Wyeth (formerly American Home Products Corporation) to jointly develop products for use in treating hepatitis C virus in humans. Under the agreement, we licensed to Wyeth
worldwide rights under certain patents and know-how owned by us or created under the agreement. We have the right to co-promote these products in the U.S. and Canada and Wyeth will promote the products elsewhere in the world. Wyeth has the right to
manufacture any commercial products developed under the agreement.

In April 2008, we announced that ViroPharma and Wyeth, have jointly discontinued the
development of HCV-796 due to the previously announced safety issue that emerged in the ongoing Phase 2 trial in patients with hepatitis C. We also announced that ViroPharma and Wyeth do not expect to continue to collaborate on future development of
hepatitis C treatment candidates.

On January 1, 2009, we implemented EITF No. 07-1, Accounting for Collaborative Arrangements Related to the
Development and Commercialization of Intellectual Property (EITF 07-1) which is focused on how the parties to a collaborative agreement should disclose costs incurred and revenue generated on sales to third parties, how sharing payments pursuant
to a collaboration agreement should be presented in the income statement and certain related disclosure questions. In accordance with EITF 07-1, we evaluated our collaborative agreements for proper income statement classification based on the nature
of the underlying activity. If payments to and from our collaborative partners are not within the scope of other authoritative accounting literature, the income statement classification for these payments is based on a reasonable, rational analogy
to authoritative accounting literature that is applied in a consistent manner. Amounts due to our collaborative partner related to development activities are reflected as a research and development expense. As of June 30, 2009, we owe Wyeth
$0.2 million related to collaboration activities for HCV-796 activities.

Note 15. Supplemental Cash Flow Information



|                                                                        |      |                          |      |      
|----------------------------------------------------------------------- | ---- | ------------------------ | ---- | -----
|(in thousands)                                                          |      | Six months endedJune 30,
|                                                                        | 2009 |                          | 2008
|                                                                        |      |                         
|Supplemental disclosure of non-cash transactions:                       |      |                          |      |      
|Employee share-based compensation                                       |      | 6,779                    |      | 4,080
|Unrealized gains on available for sale securities                       |      |                         |      | 707  
|Reversal of accrued deferred finance costs                              |      |                         |      | 151  
|Non-cash increase of intangible assets for Vancocin obligation to Lilly |      | 4,013                    |      |     
|Establishment of landlord allowance                                     |      | 32                       |      |     
|Asset retirement obligation, net of accretion                           |      |                         |      | 998  
|Debt buy back deferred tax impact                                       |      | 308                      |      |     
|Supplemental disclosure of cash flow information:                       |      |                          |      |      
|Cash paid for income taxes                                              |      | 1,895                    |      | 7,278
|Cash paid for interest                                                  |      | 2,500                    |      | 2,500
|Cash received for stock option exercises                                |      | 12                       |      | 127  
|Cash received for employee stock purchase plan                          |      | 164                      |      | 97   



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##### Table of Contents

|ITEM 2. | MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL
|------- | -------------------------------------------------

CONDITION AND RESULTS OF OPERATIONS

ViroPharma Incorporated and subsidiaries, referred to herin as ViroPharma, the
Company, we or us, is a global biopharmaceutical company dedicated to the development and commercialization of products that address serious diseases, with a focus on products used by physician specialists or in hospital settings. The
Company intends to grow through sales of its marketed products, CinryzeTMand
Vancocin, through continued development of its product pipeline and through potential acquisition or licensing of products or acquisition of companies. ViroPharma has two marketed products, and three development programs.

We market and sell Cinryze, which has been approved by the FDA for the prophylactic treatment of hereditary angioedema (HAE). Cinryze is a C1 inhibitor therapy for
routine prophylaxis against HAE, also known as C1 inhibitor deficiency, a rare, severely debilitating, life-threatening genetic disorder. Cinryze was obtained in October 2008, when we completed our acquisition of Lev Pharmaceuticals, Inc.
(Lev), a biopharmaceutical company focused on developing and commercializing therapeutic products for the treatment of inflammatory diseases. In December 2008, we submitted a supplemental Biologics Application (sBLA) for Cinryze as a treatment for
acute attacks of HAE based on a re-analysis and resubmission of data from a pivotal Phase 3 acute treatment study of Cinryze and interim data from an ongoing open label acute study of the drug. On June 4, 2009, we announced that we received a
Complete Response letter from the FDA related to its supplemental Biologics License Application (sBLA) for Cinryze(TM) (C1 esterase inhibitor [human]) as a treatment for acute attacks of hereditary angioedema (HAE). The FDA has requested an
additional clinical study, due to their opinion that the placebo controlled study submitted in support of the sBLA lacked robustness. In the Complete Response letter, the FDA cited no safety concerns related to acute treatment with Cinryze in the
clinical studies. We are currently evaluating our path forward for the acute indication of HAE. In addition, the Company announced that the FDA has approved the patient labeling for Cinryze to include self-administration for routine prophylaxis,
once patients are properly trained by their healthcare provider. We are currently evaluating with our partner Sanquin, the feasibility of additional territories, indications and/or other formulations for Cinryze. Part of this plan was obtaining
Orphan Drug designation for Europe.

The Company also markets and sells Vancocin HCl capsules, the oral capsule formulation of vancomycin hydrochloride, in
the U.S. and its territories. Vancocin is a potent antibiotic approved by the U.S. Food and Drug Administration, or FDA, to treat antibiotic-associated pseudomembranous colitis caused by Clostridium difficileinfection (CDI), or C.
difficile, and enterocolitis caused by Staphylococcus aureus, including methicillin-resistant strains.

ViroPharma is developing two product
candidates, maribavir for the prevention and treatment of cytomegalovirus, or CMV disease; and non-toxigenic strains of C. difficile (NTCD) for the treatment and prevention of CDI. On February 9, 2009, we announced that our Phase 3 trial
evaluating maribavir used as prophylaxis in allogeneic stem cell, or bone marrow, transplant (SCT) patients did not achieve its primary endpoint. In the primary analysis, there was no statistically significant difference between maribavir and
placebo in reducing the rate of CMV disease. Additionally, on February 13, 2009, we announced that enrollment in our Phase 3 trial evaluating maribavir in liver transplant patients was discontinued and that all patients on study drug were moved
to current standard of care. We discontinued dosing patients with maribavir in clinical trials and are evaluating our maribavir program in light of the Phase 3 clinical trial results.

We licensed the U.S. and Canadian rights for a third product development candidate, an intranasal formulation of pleconaril, to Schering-Plough for the treatment of picornavirus infections.

We intend to continue to evaluate in-licensing or other opportunities to acquire products in development, or those that are currently on the market. We plan to seek
products that treat serious medical conditions which require modest sales and marketing infrastructure, or to complement the markets that we hope our CMV and NTCD programs will serve or in which Vancocin and Cinryze are prescribed.

Executive Summary

Since March 31, 2009, we experienced the
following:

Business Activities

Cinryze:



| |  |  | Shipped approximately 6,300 doses of Cinryze to SP/SDs;
| | - |  | --------------------------------------------------------



| |  |  | Received a Complete Response letter from the FDA related to our sBLA for Cinryze as a treatment for acute attacks of HAE; and
| | - |  | -----------------------------------------------------------------------------------------------------------------------------



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| |  |  | FDA approved the patient labeling for Cinryze to include self-administration for routine prophylaxis;
| | - |  | -----------------------------------------------------------------------------------------------------

C. difficileinfection (CDI):



| |  |  | Continued work to optimize manufacturing and scale up of non-toxigenic C. difficilespores; and
| | - |  | ----------------------------------------------------------------------------------------------



| |  |  | Vancocin scripts decreased 10.1% in the second quarter of 2009 as compared to the second quarter of 2008;
| | - |  | ---------------------------------------------------------------------------------------------------------

CMV:



| |  |  | Recorded expenses of $4.0 million related to the wind-down of our Phase 3 clinical trials for maribavir, which has totaled $16.1 million for the six months ended
June 30, 2009;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Financial Results



| |  |  | Recorded net sales of Cinryze of $25.6 million, which includes recognition of previously deferred revenue of $2.4 million;
| | - |  | --------------------------------------------------------------------------------------------------------------------------



| |  |  | Net sales of Vancocin decreased to $56.3 million from $65.4 million in the second quarter of 2008; and
| | - |  | ------------------------------------------------------------------------------------------------------



| |  |  | Reported net income of $16.0 million in the second quarter of 2009;
| | - |  | -------------------------------------------------------------------

Liquidity



| |  |  | Generated net cash from operations of $15.9 million; and
| | - |  | --------------------------------------------------------



| |  |  | Ended the second quarter of 2009 with working capital of $327.7 million, which includes cash and cash equivalents of $267.2 million.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------

During the remainder of 2009 and going forward, we expect to face a number of challenges, which include the following:

The commercial sale of approved pharmaceutical products is subject to risks and uncertainties. There can be no assurance that future Vancocin sales will meet or exceed
the historical rate of sales for the product, for reasons that include, but are not limited to, generic and non-generic competition for Vancocin and/or changes in prescribing habits or disease incidence. Additionally, period over period fluctuations
in net product sales are expected to occur as a result of wholesaler buying decisions.

We cannot assure you that generic competitors will not take
advantage of the absence of patent protection for Vancocin to attempt to market a competing product. We are not able to predict the time period in which a generic drug may enter the market. On March 17, 2006, we learned that the FDAs
Office of Generic Drugs, Center for Drug Evaluation and Research (OGD) recommended premitting a waiver of in-vivo bioequivalence testing for copies of Vancocin if the generic applicant could show that its product was rapidly dissolving. In
December 2008, FDA changed OGDs 2006 bioequivalence recommendation by issuing draft guidance for establishing bioequivalence to Vancocin which would require generic products that have the same inactive ingredients in the same quantities as
Vancocin (Q1 and Q2 the same) to demonstrate bioequivalence through comparative in vitro dissolution testing. Under this latest proposed method, any generic product that is not Q1 and Q2 the same as Vancocin would need to conduct an
in vivo study with clinical endpoints to demonstrate bioequivalence with Vancocin. The FDA will convene a meeting of its Advisory Committee for Pharmaceutical Science and Clinical Pharmacology to discuss bioequivalence recommendations for oral
vancomycin hydrochloride capsule drug products. The meeting is scheduled for August 4, 2009. We have submitted briefing materials to the Advisory Committee for its consideration on the issues presented by OGDs bioequivalence
recommendation, and we expect to present these issues at the meeting. However, if FDAs proposed bioequivalence method for Vancocin becomes effective, the time period in which a generic competitor may enter the market would be reduced and
multiple generics may enter the market, which would materially impact our operating results, cash flows and possibly intangible asset valuations. There can be no assurance that the FDA will agree with the positions stated in our Vancocin related
submissions or that our efforts to oppose the OGDs March 2006 and December 2008 recommendations to determine bioequivalence to Vancocin through in vitro dissolution testing will be successful. We cannot predict the timeframe in which the FDA
will make a decision regarding either our citizen petition for Vancocin or the approval of generic versions of Vancocin. If we are unable to change the recommendation set forth by the OGD in March 2006 or December 2008, the threat of generic
competition will be high.

The FDA approved Cinryze for routine prophylaxis against angioedema attacks in adolescent and adult patients with hereditary
angioedema on October 10, 2008. Cinryze became commercially available for routine prophylaxis against HAE in December 2008 and the commercial success of Cinryze will depend on several factors, including: the number of patients with HAE that may
be treated with Cinryze; acceptance by physicians and patients of Cinryze as a safe and effective treatment; our ability to effectively market and distribute Cinryze in the United States; cost effectiveness of HAE treatment using Cinryze; relative
convenience and ease



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of administration of Cinryze; potential advantages of Cinryze over alternative treatments; the timing of the approval of competitive products including
another C1 esterase inhibitor for the acute treatment of HAE; patients ability to obtain sufficient coverage or reimbursement by third-party payors; sufficient supply and reasonable pricing of raw materials necessary to manufacture Cinryze;
and manufacturing or supply interruptions and capacity which could impair our ability to acquire an adequate supply of Cinryze to meet demand for the product. We also received a complete response letter from the FDA related to our sBLA for Cinryze
for the acute treatment of HAE which requested that additional clinical studies be conducted. Our inability to receive such an approval could have a material impact on future revenues from Cinryze.

We will face intense competition in acquiring additional products to expand further our product portfolio. Many of the companies and institutions that we will compete
with in acquiring additional products to expand further our product portfolio have substantially greater capital resources, research and development staffs and facilities than we have, and greater resources to conduct business development
activities. We may need additional financing in order to acquire new products in connection with our plans as described in this report.

The outcome of our
clinical development programs is subject to considerable uncertainties. We cannot be certain that we will be successful in developing and ultimately commercializing any of our product candidates, that the FDA or other regulatory authorities will not
require additional or unanticipated studies or clinical trial outcomes before granting regulatory approval, or that we will be successful in gaining regulatory approval of any of our product candidates in the timeframes that we expect, or at all.
For example, on February 9, 2009, we announced that our Phase 3 trial evaluating maribavir used as prophylaxis in allogeneic stem cell, or bone, marrow, transplant patients did not achieve its primary endpoints. In the primary analysis, there
was no statistically significant difference between maribavir and placebo in reducing the rate of CMV disease. In addition, the study failed to meet its key secondary endpoints. Maribavir was generally well tolerated in this clinical study.
Additionally, in August 2007, we and Wyeth decided to discontinue dosing with HCV-796 in a phase 2 study as a result of potential safety concerns. There can be no assurance that we will conduct additional HCV or CMV studies in the future as the FDA
or other regulatory authorities may either prohibit any future studies with HCV-796 or maribavir or alternatively may require additional or unanticipated studies or clinical trial outcomes before granting regulatory approval.

We cannot assure you that our current cash and cash equivalents or cash flows from Vancocin and Cinryze sales will be sufficient to fund all of our ongoing development
and operational costs, as well as the interest payable on our outstanding senior convertible notes, over the next several years, that planned clinical trials can be initiated, or that planned or ongoing clinical trials can be successfully concluded
or concluded in accordance with our anticipated schedule and costs. Moreover, the results of our business development efforts could require considerable investments.

Our actual results could differ materially from those results expressed in, or implied by, our expectations and assumption described in this Quarterly Report on Form 10-Q. The risks described in this report, our Form
10-Q for the quarter ended June 30, 2009 are not the only risks facing us. Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial also may materially adversely affect our business, financial
condition and/or operating results. Please also see our discussion of the Risk Factors as described in our Form 10-K for the year ended December 31, 2008 and our Quarterly Report on Form 10-Q for the quarter ended March 31,
2009 in Item 1A, which describe other important matters relating our business.

Results of Operations

Three and Six-months ended June 30, 2009 and 2008



|                                                         |  |                                    |        |                                  |   |        |  |   |         |   |  |   |        
|-------------------------------------------------------- |  | ---------------------------------- | ------ | -------------------------------- | - | ------ |  | - | ------- | - |  | - | -------
|                                                         |  | For the three months endedJune 30, |        | For the six months endedJune 30,
|(in thousands, except per share data)                    |  | 2009                               |        | 2008                             |   | 2009   |  |   | 2008   
|Net product sales                                        |  | $                                  | 81,873 |                                  | $ | 65,437 |  | $ | 142,063 |   |  | $ | 116,374
|                                                         |  |                                    |        |                                  |   |        |  |   |         |   |  |   |        
|Cost of sales (excluding amortization of product rights) |  |                                    | 14,121 |                                  |   | 2,386  |  |   | 18,049  |   |  |   | 4,304  
|                                                         |  |                                    |        |                                 
|Operating income (loss)                                  |  |                                    | 24,249 |                                  |   | 29,717 |  |   | (35,907 | ) |  |   | 49,234 
|                                                         |  |                                    |        |                                 
|Net income (loss)                                        |  |                                    | 16,052 |                                  |   | 22,783 |  |   | (43,163 | ) |  |   | 39,168 
|Net income (loss) per share:                             |  |                                    |        |                                  |   |        |  |   |         |   |  |   |        
|Basic                                                    |  | $                                  | 0.21   |                                  | $ | 0.33   |  | $ | (0.56   | ) |  | $ | 0.56   
|Diluted                                                  |  | $                                  | 0.20   |                                  | $ | 0.29   |  | $ | (0.56   | ) |  | $ | 0.51   



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The $24.2 million in operating income for the three month period ended June 30, 2009 decreased $5.5 million as
compared to the same period in 2008 resulted primarily from a decrease in Vancocin sales, the increased cost of sales associated with Cinryze, increased Selling, General and Administrative (SG&A) costs related to the launch of Cinryze and
increased amortization, offset by increased net sales from Cinryze. The $35.9 million in operating loss for the six months ended June 30, 2009 as compared to the same period in 2008 resulted from the impairment of goodwill in the first quarter
of 2009 and increased costs associated with our acquisition of Lev including cost of sales, intangible amortization and increased SG&A costs related to the launch of Cinryze, partially offset by net sales of Vancocin and Cinryze.

Revenues

Revenues consisted of the following:



|                  |  |                                    |        |                                  |   |        |  |      |         |  |   |        
|----------------- |  | ---------------------------------- | ------ | -------------------------------- | - | ------ |  | ---- | ------- |  | - | -------
|                  |  | For the three months endedJune 30, |        | For the six months endedJune 30,
|(in thousands)    |  | 2009                               |        | 2008                             |   | 2009   |  | 2008
|Net product sales |  |                                    |        |                                  |   |        |  |      |         |  |   |        
|Vancocin          |  | $                                  | 56,302 |                                  | $ | 65,437 |  | $    | 109,836 |  | $ | 116,374
|Cinryze           |  |                                    | 25,571 |                                  |   |       |  |      | 32,227  |  |   |       
|                  |  |                                    |        |                                  |   |        |  |      |         |  |   |        
|Total revenues    |  | $                                  | 81,873 |                                  | $ | 65,437 |  | $    | 142,063 |  | $ | 116,374
|                  |  |                                    |        |                                  |   |        |  |      |         |  |   |        

RevenueVancocin and Cinryze product sales

Our net product sales are related to Vancocin and Cinryze. We sell Vancocin only to wholesalers who then distribute the product to pharmacies, hospitals and long-term
care facilities, among others. Our sales of Vancocin are influenced by wholesaler forecasts of prescription demand, wholesaler buying decisions related to their desired inventory levels, and, ultimately, end user prescriptions, all of which could be
at different levels from period to period.

We sell Cinryze to specialty pharmacy/ specialty distributors (SP/SDs) who then sell and distribute to
physicians, hospitals and patients, among others. Beginning in the second quarter of 2009, we now recognized revenue based upon shipments of Cinryze to SP/SDs due to our ability to meet the revenue recognition criteria under SAB 104,
specifically our ability to estimate our payor mix. We previously recognized revenue upon shipment of Cinryze from SP/SDs to patients. We recognized $2.4 million of net sales in the second quarter that was previously classified as deferred
revenue.

During the three and six months ended June 30, 2009, net sales of Vancocin decreased 14.0% and 5.6%, respectively, compared to the same
periods in 2008. The decrease for the three and six months ended June 30, 2008 is primarily due to lower sales volumes, partially offset by the price increase in January 2009. Based upon data reported by IMS Health Incorporated, prescriptions
during the three and six months ended June 30, 2009 decreased from the same period in 2008 period by 10.1% and 6.2%, respectively. The units sold for the three and six months ended June 30, 2009 decreased by 16.4% and 10.3%, respectively,
compared to the same periods in 2008.

Vancocin and Cinryze product sales are influenced by prescriptions and wholesaler forecasts of prescription demand,
which could be at different levels from period to period. We receive inventory data from our three largest wholesalers through our fee for service agreements and our two SP/SDs through service agreements. We do not independently verify this
data. Based on this inventory data and our estimates, we believe that as of June 30, 2009, the wholesalers and SP/SDs did not have excess channel inventory.

Cost of sales (excluding amortization of product rights)

Cost of sales increased for the three and six months
periods ended June 30, 2009 by $11.7 million and $13.7 million, respectively, as compared to the same period in the prior year due to the launch of Cinryze. Included in the Cost of sales for the three and six months periods ended June 30
was $1.8 million that was previously deferred. Cost of sales during the three and six months ended June 30, 2008 did not include Cinryze as we acquired Lev Pharmaceuticals in October 2008. Vancocin and Cinryze cost of sales includes the cost of
materials and distribution costs and excludes amortization of product rights. As part of our October 2008 purchase of Lev, we acquired Cinryze inventory which was recorded at fair value in purchase accounting. This step-up of inventory value
increased the cost of sales during the three and six months ended June 30, 2009. As of June 30, 2009, the value of the remaining inventory step-up on our balance sheet was $0.7 million.



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Since units are shipped based upon earliest expiration date, we would expect the cost of product sales of both Vancocin
and Cinryze to fluctuate from quarter to quarter as we may experience fluctuations in quarterly manufacturing yields.

Research and development expenses

For each of our research and development programs, we incur both direct and indirect expenses. Direct expenses include third party costs related to
these programs such as contract research, consulting, cost sharing payments or receipts, and preclinical and development costs. Indirect expenses include personnel, facility, stock compensation and other overhead costs. Due to advancements in our
NTCD preclinical program, the start of our Phase 4 commitment for Cinryze, we expect costs in these programs to exceed current costs. We are evaluating our maribavir program and will continue to incur additional costs necessary to complete certain
activities related to the Phase 3 studies which were discontinued in February 2009.

Research and development expenses were divided between our research
and development programs in the following manner:



|                                           |  |                                    |        |                                  |   |        |  |      |        |  |   |       
|------------------------------------------ |  | ---------------------------------- | ------ | -------------------------------- | - | ------ |  | ---- | ------ |  | - | ------
|                                           |  | For the three months endedJune 30, |        | For the six months endedJune 30,
|(in thousands)                             |  | 2009                               |        | 2008                             |   | 2009   |  | 2008
|                                           |  |                                    |        |                                 
|Direct  Core programs                     |  |                                    |        |                                  |   |        |  |      |        |  |   |       
|CMV                                        |  | $                                  | 3,383  |                                  | $ | 9,466  |  | $    | 13,146 |  | $ | 18,876
|HCV                                        |  |                                    |       |                                  |   | 375    |  |      | 8      |  |   | 750   
|Cinryze                                    |  |                                    | 1,484  |                                  |   |       |  |      | 3,975  |  |   |      
|Vancocin                                   |  |                                    | 151    |                                  |   |       |  |      | 421    |  |   | 10    
|Non-toxigenic strains of C. difficle(NTCD) |  |                                    | 2,606  |                                  |   | 823    |  |      | 4,454  |  |   | 1,872 
|Indirect                                   |  |                                    |        |                                  |   |        |  |      |        |  |   |       
|Development                                |  |                                    | 4,843  |                                  |   | 3,920  |  |      | 10,147 |  |   | 7,491 
|                                           |  |                                    |        |                                  |   |        |  |      |        |  |   |       
|Total                                      |  | $                                  | 12,467 |                                  | $ | 14,584 |  | $    | 32,151 |  | $ | 28,999
|                                           |  |                                    |        |                                  |   |        |  |      |        |  |   |       

Direct ExpensesCore Development Programs

Our direct expenses related to our CMV program decreased during the three and six months ended June 30, 2009 as we wind-down our stem cell and liver transplant
studies. Costs incurred during 2009 include our continued enrollment in our solid organ (liver) study through February 2009, conducting follow-up visits and continuing to evaluate the results of our Phase 3 programs. In February 2009, based upon
preliminary analysis of the data, we announced that our Phase 3 trial evaluating maribavir used as prophylaxis in allogeneic stem cell, or bone, marrow, transplant patients did not achieve its primary endpoints. In the primary analysis, there was no
statistically significant difference between maribavir and placebo in reducing the rate of CMV disease. In addition, the study failed to meet its key secondary endpoints. We are continuing to analyze the study results. Additionally, we announced
that our Phase 3 trial evaluating maribavir in liver transplant patients was discontinued and that all patients on study drug were moved to the current standard of care. This decision was made based on the results of the Phase 3 study of maribavir
in stem cell transplant patients, and the recommendation from our independent Data Monitoring Committee who considered the rate of viremia in both arms of the study. During 2008, we continued recruitment and site initiations into ongoing phase 3
studies of maribavir in patients undergoing allogeneic stem cell transplant at transplant centers in the U.S., Canada and several European Countries and patients undergoing liver transplantation in the U.S. and Europe. Additionally, we began
executing on our pre-launch plans for our clinical, regulatory and commercial activities for maribavir in the U.S. and Europe.

Related to our HCV program,
costs incurred in the first six months of 2009 primarily represent those paid to Wyeth in connection with the wind down of our cost-sharing arrangement related to discovery efforts to identify potential back-ups/follow-on compounds to HCV-796. In
April 2008, we announced that ViroPharma and Wyeth have jointly discontinued the development of HCV-796 due to the previously announced safety issue that emerged in the ongoing Phase 2 trial in patients with hepatitis C. We also announced that
ViroPharma and Wyeth do not expect to continue to collaborate on future development of hepatitis C treatment candidates.



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In October 2008, we acquired Cinryze, a C1 inhibitor, which has been approved by the FDA for routine prophylaxis of HAE.
During 2009, we incurred costs related to the Cinryze open label trials which closed on March 31, 2009 and preparation for our Phase 4 clinical trial.

The increase in costs of NTCD in the six months of 2009 over 2008 relate to increased research and development activities, costs associated with manufacturing NTCD spores and costs associated with preparations for our Phase 1 clinical
trial.

Vancocin costs in the first six months of 2009 and 2008 related to additional research activities.

Anticipated fluctuations in future direct expenses are discussed under Liquidity  Development Programs.

Indirect Expenses

These costs primarily relate to the compensation
of and overhead attributable to our development team, the increase primarily relates to the year over year headcount increase from the first six months of 2008.

Selling, general and administrative expenses

Selling, general and administrative expenses (SG&A) increased for the three and six months
ended June 30, 2009 $7.0 million and $18.0 million, respectively, compared to the same periods in 2008. For the six month period, the largest contributors to this increase over the six month period in 2008 were increased compensation costs
resulting primarily from the expansion of our field force ($8.2 million), increased marketing efforts ($2.8 million), increased legal and accounting fees ($2.0 million), and increased medical education activities ($1.3 million). Included in SG&A
are legal and consulting costs incurred related to our opposition to the attempt by the OGD regarding the conditions that must be met in order for a generic drug application to request a waiver of in-vivo bioequivalence testing for copies of
Vancocin, which were $1.4 million and $1.8 million for the first half of 2009 and 2008, respectively. We anticipate that these additional legal and consulting costs will continue at the current level, or possibly higher, in future periods as we
continue this opposition. We anticipate continued increased spending in selling, general and administrative expenses in future periods as we continue the commercial launch of Cinryze.

Intangible amortization and acquisition of technology rights

Intangible amortization is the result of the Vancocin
product rights acquisition in the fourth quarter of 2004 as well as the acquisition of Cinryze product rights in October 2008. Additionally, as described in our agreement with Lilly, to the extent that we incur an obligation to Lilly for additional
payments on Vancocin sales, we have contingent consideration. We record the obligation as an adjustment to the carrying amount of the related intangible asset and a cumulative adjustment to the intangible amortization upon achievement of the related
sales milestones. Contingent consideration and Lilly related additional payments are more fully described in Note 4 of the Unaudited Consolidated Financial Statements.

Intangible amortization for the three and six months periods ended June 30, 2009 were $7.4 million and $14.7 million, respectively as compared to $2.1 million and $3.8 million, respectively in 2008. Amortization
is higher in 2009 as compared to 2008 due to intangible asset acquired in our acquisition of Lev Pharmaceuticals.

On an ongoing periodic basis, we
evaluate the useful life of our intangible assets and determine if any economic, governmental or regulatory event has modified their estimated useful lives. This evaluation did not result in a change in the life of the intangible assets during the
quarter ended June 30, 2009. We will continue to monitor the actions of the FDA and OGD surrounding the bioequivalence recommendation for Vancocin and consider the effects of our opposition efforts, the announcements by generic competitors or
other adverse events for additional impairment indicators. We will reevaluate the expected cash flows and fair value of our Vancocin-related assets, as well as estimated useful lives, at such time.

Other Income (Expense)

Interest Income

Interest income for three and six months ended June 30, 2009 was $0.1 million and $0.3 million, respectively, and as compared to $4.0 million and $10.4 million in
the respective periods in 2008. Interest income for both periods in 2009 as compared to 2008 decreased due to lower amounts of cash on hand and lower interest rates.



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Interest Expense



|                                             |  |                                    |       |                                  |   |       |  |      |       |  |   |      
|-------------------------------------------- |  | ---------------------------------- | ----- | -------------------------------- | - | ----- |  | ---- | ----- |  | - | -----
|                                             |  | For the three monthsended June 30, |       | For the six monthsended June 30,
|(in thousands)                               |  | 2009                               |       | 2008                             |   | 2009  |  | 2008
|                                             |  |                                    |       |                                 
|Interest expense on senior convertible notes |  | $                                  | 998   |                                  | $ | 1,250 |  | $    | 2,248 |  | $ | 2,481
|Amortization of debt discount                |  |                                    | 1,582 |                                  |   | 1,768 |  |      | 3,520 |  |   | 3,559
|Amortization of finance costs                |  |                                    | 97    |                                  |   | 200   |  |      | 218   |  |   | 306  
|                                             |  |                                    |       |                                  |   |       |  |      |       |  |   |      
|Total interest expense                       |  | $                                  | 2,677 |                                  | $ | 3,218 |  | $    | 5,986 |  | $ | 6,346
|                                             |  |                                    |       |                                  |   |       |  |      |       |  |   |      

Interest expense and amortization of finance costs in 2009 and 2008 relates entirely to the senior convertible
notes issued on March 26, 2007, as described in Note 7 to the Unaudited Consolidated Financial Statements.

Income Tax Expense

Our income tax expense was $5.6 million and $7.8 million for the quarters ended June 30, 2009 and 2008, respectively and $10.6 million and
$14.1 million for the six months ended June 30, 2009 and 2008, respectively. Our income tax expense includes federal, state and foreign income taxes at statutory rates and the effects of various permanent differences. The income tax expense in
the first six months of 2009 reflects the full impact of our gain on the repurchase of a portion of our convertible notes. In addition, our full year tax expense will include the effect of our current estimate of the impact of the orphan drug credit
for maribavir. The decrease in the 2009 expense as compared to 2008 is primarily due to the decrease in taxable income from 2008. We continue to evaluate our qualified expenses and, to the extent that actual qualified expenses vary significantly
from our estimates, our tax expense will be impacted.

During the six months ended June 30, 2009, we paid approximately $1.2 million as a result of
the IRS audit of the Companys 2006 federal income tax return and results in a reduction of our taxes payable liability. We also have various state returns currently under examination. The final outcome of these reviews are not yet
determinable.

Liquidity

We expect that our near term
sources of revenue will arise from Vancocin and Cinryze product sales. However, we cannot predict what the actual sales of Vancocin will be in the future, and the outcome of our effort to oppose the OGDs approach to bioequivalence
determinations for generic copies of Vancocin is uncertain. In addition, there are no assurances that demand for Vancocin will continue at historical or current levels. Finally, we cannot predict the actual sales of Cinryze as the product has just
recently been launched commercially and has no history of revenue.

Our ability to generate positive cash flow is also impacted by the timing of
anticipated events in our HAE, CMV and NTCD programs, including the scope of the clinical trials required by regulatory authorities, results from clinical trials, the results of our product development efforts, and variations from our estimate of
future direct and indirect expenses.

While we anticipate that cash flows from Vancocin and Cinryze, as well as our current cash and cash equivalents,
should allow us to fund substantially all of our ongoing development and other operating costs for the foreseeable future, as well as the interest payable on our senior convertible notes, we may need additional financing in order to expand our
product portfolio. At June 30, 2009, we had cash and cash equivalents of $267.2 million.

Overall Cash Flows

During the six months ended June 30, 2009, we were provided with $15.9 million of net cash from operating activities, primarily from our net loss offset for non-cash
items such as our goodwill impairment and depreciation and amortization expense, and our changes in working capital, specifically increases in accounts receivable, inventory and accrued expenses and other current liabilities. We used $4.0 million of
cash from investing activities and our net cash used in financing activities for the quarter ended June 30, 2009 was $20.7 million, mainly in the repurchase of a portion of our senior convertible notes.



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Operating Cash Inflows

We began to receive cash inflows from the sale of Vancocin in January 2005 and Cinryze in 2009. We cannot reasonably estimate the period in which we will begin to receive material net cash inflows from Cinryze that could cover our operating
expenses. Cash inflows from development-stage products are dependent on achievement of regulatory approvals. We may not receive revenues if a development stage product fails to obtain regulatory approvals. The most significant of our near-term
operating development cash inflows are as described under Development Programs as set forth below.

Operating Cash Outflows

The cash flows we have used in operations historically have been applied to research and development activities, marketing and business development
efforts, general and administrative expenses, servicing our debt, and income tax payments. Bringing drugs from the preclinical research and development stage through phase 1, phase 2, and phase 3 clinical trials and FDA approval is a time consuming
and expensive process. Because our product candidates are currently in the clinical stage of development, there are a variety of events that could occur during the development process that will dictate the course we must take with our drug
development efforts and the cost of these efforts. As a result, we cannot reasonably estimate the costs that we will incur through the commercialization of any product candidate. However, we anticipate we will continue to invest in our pipeline on
our initiative to develop non-toxigenic strains of C. difficile, our phase 4 program for Cinryze, evaluating additional indications and territories for Cinryze and our maribavir program, future costs may exceed current costs. We are also
required to pay contingent consideration to Lev shareholders upon certain regulatory and commercial milestones. The most significant of our near-term operating development cash outflows are as described under Development
Programs as set forth below.

Direct Expenses - Development Programs

For each of our development programs, we incur both direct and indirect expenses. Direct expenses include third party costs related to these programs such as contract
research, consulting, cost sharing payments or receipts, and preclinical and clinical development costs. Indirect expenses include personnel, facility and other overhead costs. Additionally, for some of our development programs, we have cash inflows
and outflows upon achieving certain milestones.

Core Development Programs

NTCDWe acquired NTCD in February 2006 and through June 30, 2009 have spent approximately $10.9 million in direct research and development costs. During the remainder of 2009, we expect our
research and development activities related to NTCD to increase significantly as we expect to commence clinical studies with NTCD during 2009.

CinryzeWe acquired Cinryze in October 2008 and through June 30, 2009 have spent approximately $9.2 million in direct research and development costs related to Cinryze since acquisition. During the remainder of 2009, we
continue to expect research and development costs related to Cinryze as we complete our Phase 4 commitment. Additionally, we will incur costs related to evaluating additional indications, formulations and territories as we develop our life cycle
program related to Cinryze. We are solely responsible for the costs of Cinryze development.

CMV programFrom the date we in-licensed maribavir
through June 30, 2009, we paid $95.9 million of direct costs in connection with this program, including the acquisition fee of $3.5 million paid to GSK for the rights to maribavir in September 2003 and a $3.0 million milestone payment in
February 2007.

During the remainder of 2009, we will continue to analyze the study results for the Phase 3 trial evaluating maribavir used as prophylaxis
stem cell transplant patients that did not achieve its primary endpoint. In the remainder of 2009, we will continue to incur costs related to analyzing our Phase 3 results, patient monitoring and study wind down costs. We are solely responsible for
the cost of developing our CMV product candidate.

Should we achieve certain product development events, we are obligated to make certain milestone
payments to GSK, the licensor of maribavir.

HCV programFrom the date that we commenced predevelopment activities for compounds in this
program that are currently active through June 30, 2009, we paid $6.0 million in direct expenses for the predevelopment and development activities relating to such compounds. These costs are net of contractual cost sharing arrangements between
Wyeth and us. Wyeth pays a substantial portion of the collaborations predevelopment and development expenses.



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In April 2008 we, along with Wyeth, discontinued the development of HCV-796 due to the previously announced safety issue
that emerged in the ongoing Phase 2 trial in patients with hepatitis C. Additionally, we announced that ViroPharma and Wyeth do not expect to continue to collaborate on future development of hepatitis C treatment candidates.

VancocinWe acquired Vancocin in November 2004 and through June 30, 2009, we have spent approximately $1.4 million in direct research and development
costs related to Vancocin activities since acquisition.

Business development activities

Through June 30, 2009, we paid an acquisition price of $116.0 million, paid $33.1 million related to additional purchase price consideration tied to product sales
(see Note 4 of the Unaudited Consolidated Financial Statements). Based on net sales in the second quarter of 2009, $4.0 million is due to Lilly on net sales of Vancocin above the net sales levels reflected above.

On October 21, 2008, we completed our acquisition under which ViroPharma acquired Lev Pharmaceuticals, Inc. (Lev). Lev is a biopharmaceutical company focused on
developing and commercializing therapeutic products for the treatment of inflammatory diseases. The terms of the merger agreement provided for the conversion of each share of Lev common stock into upfront consideration of $453.1 million, or $2.75
per Lev share, comprised of $2.25 per share in cash and $0.50 per share in ViroPharma common stock, and contingent consideration of up to $1.00 per share which may be paid on achievement of certain regulatory and commercial milestones. The Company
used approximately $385 million of existing cash and cash equivalents to fund the acquisition, including deal related expenses, and issued 7,359,667 shares in conjunction with the merger.

We intend to seek to acquire additional products or product candidates. The costs associated with evaluating or acquiring any additional product or product candidate can
vary substantially based upon market size of the product, the commercial effort required for the product, the products current stage of development, and actual and potential generic and non-generic competition for the product, among other
factors. Due to the variability of the cost of evaluating or acquiring business development candidates, it is not feasible to predict what our actual evaluation or acquisition costs would be, if any, however, the costs could be substantial.

Senior Convertible Notes

On March 26,
2007, the Company issued $250.0 million of 2% senior convertible notes due March 2017 (the senior convertible notes) in a public offering. The $250.0 million includes an issuance pursuant to the underwriters exercise of an
overallotment in the amount of $25.0 million that was closed concurrently on March 26, 2007. Net proceeds from the issuance of the senior convertible notes were $241.8 million. The senior convertible notes are unsecured unsubordinated
obligations and rank equally with any other unsecured and unsubordinated indebtedness. The senior convertible notes bear interest at a rate of 2% per annum, payable semi-annually in arrears on March 15 and September 15 of each
year commencing on September 15, 2007.

The Company adopted FSP APB 14-1 as of January 1, 2009 and retrospectively applied this change in
accounting to all prior periods presented for which we had applicable outstanding convertible debt, as required by this new standard. Under this new method of accounting, the debt and equity components of our convertible debt securities is
bifurcated and accounted for separately. Under this new method of accounting, the convertible debt securities will recognize interest expense at effective rates of 8.0% as they are accreted to par value. Under this new method of accounting, the
Companys interest expense increased by approximately $7.1 million and $5.2 million in 2008 and 2007, respectively.

On March 24, 2009 the
Company repurchased, in a privately negotiated transaction, $45.0 million in principal amount of the Companys senior convertible notes due March 2017 for total consideration of approximately $21.2 million. The repurchase represented 18%
of our then outstanding debt and was executed at a price equal to 47% of par value. Following these repurchases, senior convertible notes representing $205.0 million of principal debt are outstanding with a carrying value of $133.7 million as of
March 31, 2009. The senior convertible note repurchase will reduce the companys cash and non-cash interest expense for the balance of fiscal 2009 by approximately $0.7 million and $1.2 million respectively. Additionally, in negotiated
transactions, the Company sold approximately 2.38 million call options for approximately $1.8 million and repurchased approximately 2.38 million warrants for approximately $1.5 million which terminated the call options and warrants were
previously entered into by the Company in March 2007. The Company recognized a $9.1 million gain in the first quarter of 2009 as a result of this debt extinguishment. For tax purposes the gain qualifies for deferral until 2014 in accordance
with the provisions of the American Recovery and Reinvestment Act.



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As of June 30, 2009, the Company has accrued $1.2 million in interest payable to holders of the senior convertible
notes. Debt issuance costs of $4.8 million have been capitalized and are being amortized over the term of the senior convertible notes, with the balance to be amortized as of June 30, 2009 being $3.0 million.

The senior convertible notes are convertible into shares of the Companys common stock at an initial conversion price of $18.87 per share. The senior
convertible notes may only be converted: (i) anytime after December 15, 2016; (ii) during the five business-day period after any five consecutive trading day period (the measurement period) in which the price per note for
each trading day of that measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion rate on each such day; (iii) during any calendar quarter (and only during such quarter) after
the calendar quarter ending June 30, 2007, if the last reported sale price of our common stock for 20 or more trading days in a period of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter
exceeds 130% of the applicable conversion price in effect on the last trading day of the immediately preceding calendar quarter; or (iv) upon the occurrence of specified corporate events. Upon conversion, holders of the senior convertible notes
will receive shares of common stock, subject to ViroPharmas option to irrevocably elect to settle all future conversions in cash up to the principal amount of the senior convertible notes, and shares for any excess. We can irrevocably
elect this option at any time on or prior to the 35th scheduled trading day prior to the maturity date of the senior convertible notes. The senior convertible notes may be required to be repaid on the occurrence of certain fundamental changes,
as defined in the senior convertible notes. As of June 30, 2009, the fair value of the principal of the $205.0 million convertible senior notes outstanding was approximately $112.4 million, based on the level 2 valuation hierarchy
under SFAS 157.

Concurrent with the issuance of the senior convertible notes, the Company entered into privately-negotiated transactions, comprised of
purchased call options and warrants sold, to reduce the potential dilution of our common stock upon conversion of the senior convertible notes. The transactions, taken together, have the effect of increasing the initial conversion price to
$24.92 per share. The net cost of the transactions was $23.3 million.

The call options allowed ViroPharma to receive up to approximately
13.25 million shares of its common stock at $18.87 per share from the call option holders, equal to the number of shares of common stock that ViroPharma would issue to the holders of the senior convertible notes upon conversion. These call
options will terminate upon the earlier of the maturity dates of the related senior convertible notes or the first day all of the related senior convertible notes are no longer outstanding due to conversion or otherwise. Concurrently, the
Company sold warrants to the warrant holders to receive shares of its common stock at an exercise price of $24.92 per share. These warrants expire ratably over a 60-day trading period beginning on June 13, 2017 and will be net-share settled.

The purchased call options are expected to reduce the potential dilution upon conversion of the senior convertible notes in the event that the market
value per share of ViroPharma common stock at the time of exercise is greater than $18.87, which corresponds to the initial conversion price of the senior convertible notes, but less than $24.92 (the warrant exercise price). The warrant exercise
price is 75.0% higher than the price per share of $14.24 of the Companys stock on the pricing date. If the market price per share of ViroPharma common stock at the time of conversion of any senior convertible notes is above the strike
price of the purchased call options ($18.87), the purchased call options will entitle the Company to receive from the counterparties in the aggregate the same number of shares of our common stock as the Company would be required to issue to the
holder of the converted senior convertible notes. Additionally, if the market price of ViroPharma common stock at the time of exercise of the sold warrants exceeds the strike price of the sold warrants ($24.92), the Company will owe the
counterparties an aggregate of approximately 13.25 million shares of ViroPharma common stock. If we have insufficient shares of common stock available for settlement of the warrants, we may issue shares of a newly created series of
preferred stock in lieu of our obligation to deliver common stock. Any such preferred stock would be convertible into 10% more shares of our common stock than the amount of common stock we would otherwise have been obligated to deliver under the
warrants. The Company is now entitled to receive approximately 10.87 million shares of its common stock at $18.87 from the call option holders and if the market price of ViroPharma common stock at the time of exercise of the sold warrants
exceeds the strike price of the sold warrants ($24.92), will owe the counterparties an aggregate of approximately 10.87 million shares of ViroPharma common stock.

The purchased call options and sold warrants are separate transactions entered into by the Company with the counterparties, are not part of the terms of the senior convertible notes, and will not affect the
holders rights under the senior convertible notes. Holders of the senior convertible notes will not have any rights with respect to the purchased call options or the sold warrants. The purchased call options and sold warrants meet the
definition of derivatives under SFAS No. 133, Accounting for Derivative Instruments and Hedging Activities. These instruments have been determined to be indexed to the Companys own stock (in accordance with the guidance
of EITF Issue No. 01-6, The Meaning of Indexed to a Companys Own Stock) and have been recorded in stockholders



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equity in the Companys Consolidated Balance Sheet (as determined under EITF Issue No. 07-5, Determining Whether an Instrument (or Embedded
Feature) Is Indexed to an Entitys Own Stock). As long as the instruments are classified in stockholders equity they are not subject to the mark to market provisions of SFAS No. 133.

From time to time, we make seek approval from our board of directors to evaluate additional opportunities to repurchase our common stock or convertible notes, including
through open market purchases or individually negotiated transactions.

Capital Resources

While we anticipate that revenues from Vancocin and Cinryze will continue to generate positive cash flow and should allow us to fund substantially all of our ongoing
development and other operating costs, we may need additional financing in order to expand our product portfolio. Should we need financing, we would seek to access the public or private equity or debt markets, enter into additional arrangements with
corporate collaborators to whom we may issue equity or debt securities or enter into other alternative financing arrangements that may become available to us.

Financing

If we raise additional capital by issuing equity securities, the terms and prices for these financings may be much more favorable
to the new investors than the terms obtained by our existing stockholders. These financings also may significantly dilute the ownership of existing stockholders.

If we raise additional capital by accessing debt markets, the terms and pricing for these financings may be much more favorable to the new lenders than the terms obtained from our prior lenders. These financings also may require liens on
certain of our assets that may limit our flexibility.

Additional equity or debt financing, however, may not be available on acceptable terms from any
source as a result of, among other factors, our operating results, our inability to achieve regulatory approval of any of our product candidates, our inability to generate revenue through our existing collaborative agreements, and our inability to
file, prosecute, defend and enforce patent claims and or other intellectual property rights. If sufficient additional financing is not available, we may need to delay, reduce or eliminate current development programs, or reduce or eliminate other
aspects of our business.

Critical Accounting Policies

Our consolidated financial statements and accompanying notes are prepared in accordance with accounting principles generally accepted in the United States of America. Preparing consolidated financial statements requires us to make estimates
and assumptions that affect the reported amounts of assets, liabilities, revenues and expenses and contingent assets and liabilities. Actual results could differ from such estimates. These estimates and assumptions are affected by the application of
our accounting policies. Critical policies and practices are both most important to the portrayal of a companys financial condition and results of operations, and require managements most difficult, subjective or complex judgments, often
as a result of the need to make estimates about the effects of matters that are inherently uncertain.

Our summary of significant accounting policies is
described in Note 2 to our Consolidated Financial Statements contained in our Annual Report on Form 10-K for the year ended December 31, 2008. However, we consider the following policies and estimates to be the most critical in understanding
the more complex judgments that are involved in preparing our consolidated financial statements and that could impact our results of operations, financial position, and cash flows:



| |  |  | Product SalesOur net sales consist of revenue from sales of our products, Vancocin and Cinryze, less estimates for chargebacks, rebates, distribution service
fees, returns and losses. We recognize revenue for product sales when title and risk of loss has passed to the customer, which is typically upon delivery to the customer, when estimated provisions for chargebacks, rebates, distribution service fees,
returns and losses are reasonably determinable, and when collectability is reasonably assured. Revenue from the launch of a new or significantly unique product may be deferred until estimates can be made for chargebacks, rebates and losses and all
of the above conditions are met and when the product has achieved market acceptance, which is typically based on dispensed prescription data and other information obtained during the period following launch.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | At the end of each reporting period, as part of an analysis of returns, utilizing our revenue recognition policy (which follows the criteria of SEC Staff Accounting
Bulletin No. 104 Revenue Recognition, including SFAS No. 48, Revenue Recognition When Right of Return Exists) we analyze our estimated channel inventory and we would defer recognition of revenue on product that has been
delivered if we believe that channel inventory at a period end is in excess of ordinary business needs. Further, in connection with our analysis of returns, if we believe channel inventory levels are increasing without a reasonably correlating
increase in prescription demand, we proactively delay the processing of wholesaler orders until these levels are reduced.
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We establish accruals for chargebacks and rebates, sales discounts and product returns. These accruals
are primarily based upon the history of Vancocin and for Cinryze they are based on information on payees obtained from our SP/SDs and CinryzeSolutions. We also consider the volume and price of our products in the channel, trends in
wholesaler inventory, conditions that might impact patient demand for our product (such as incidence of disease and the threat of generics) and other factors.

In addition to internal information, such as unit sales, we use information from external resources, which we do not verify, to estimate the Vancocin channel inventory. Our external resources include prescription data
reported by IMS Health Incorporated and written and verbal information obtained from our three largest wholesaler customers with respect to their inventory levels. Based upon this information, we believe that inventory held at these warehouses are
within normal levels.

Chargebacks and rebates are the most subjective sales related accruals. While we currently have no contracts with
private third party payors, such as HMOs, we do have contractual arrangements with governmental agencies, including Medicaid. We establish accruals for chargebacks and rebates related to these contracts in the period in which we record the
sale as revenue. These accruals are based upon historical experience of government agencies market share, governmental contractual prices, our current pricing and then-current laws, regulations and interpretations. We analyze the accrual at
least quarterly and adjust the balance as needed. We believe that if our estimates of the rate of chargebacks and rebates as a percentage of annual gross sales were incorrect by 5%, our operating income and accruals would be impacted by
approximately $1.5 million in the period of correction, which we believe is immaterial.

Annually, as part of our process, we performed an
analysis on the share of Vancocin and Cinryze sales that ultimately go to Medicaid recipients and result in a Medicaid rebate. As part of that analysis, we considered our actual Medicaid historical rebates processed, total units sold and
fluctuations in channel inventory. We also consider our payee mix for Cinryze based on information obtained at the time of prescription.

Product returns are minimal. Product return accruals are estimated based on Vancocins history of damage and product expiration returns and are recorded in the period in which we record the sale of revenue. Cinryze has a no returns
policy. At each reporting period, we also compare our returns accrual balance to the estimated channel inventory to ensure the accrual balance is reasonable and within an acceptable range. For example, if the estimated channel inventory is at a high
level, we could be required to adjust our accrual upward.

Discounts are related to payment terms and are fully accrued in the period in
which we record the sale of revenue. Since our customers consistently take the payment discount, we do not believe that future periods will be materially impacted by a change in a previous discount accrual.



| |  |  | Impairment of Long-lived AssetsWe review our fixed and intangible assets for possible impairment annually and whenever events occur or circumstances indicate
that the carrying amount of an asset may not be recoverable in accordance with SFAS No. 144, Accounting for the Impairment or Disposal of Long-Lived Assets(SFAS 144). Assumptions and estimates used in the evaluation of impairment may
affect the carrying value of long-lived assets, which could result in impairment charges in future periods. Such assumptions include, for example, projections of future cash flows and the timing and number of generic/competitive entries into the
market, in determining the undiscounted cash flows, and if necessary, the fair value of the asset and whether an impairment exists. These assumptions are subjective and could result in a material impact on operating results in the period of
impairment. While we reviewed our intangible assets in March 2006 and December 2008 in light of the actions taken by the OGD, we did not recognize any impairment charges. See Note 4 of the Consolidated Financial Statements for further information.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

On an ongoing periodic basis, we evaluate the useful life of intangible assets and determine if any economic,
governmental or regulatory event has modified their estimated useful lives. While we reviewed the useful life of our intangible assets in March 2006 and December 2008 in light of the actions taken by the OGD, we did not change the useful life of our
intangible assets. See Note 4 of the Consolidated Financial Statements for further information.

We will continue to monitor the actions of
the OGD and consider the effects of our opposition actions and the announcements by generic competitors or other adverse events for additional impairment indicators and we will reevaluate the expected cash flows, fair value of our Vancocin-related
assets, and remaining estimated useful life at such time.



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| |  |  | Impairment of GoodwillWe review the carrying value of goodwill, to determine whether impairment may exist. SFAS No. 142, Goodwill and Other Intangible
Assets, requires that goodwill be assessed annually for impairment using fair value measurement techniques, unless a triggering event occurs between annual assessments which would then require an assessment at the end of the quarter in which a
triggering event occurred.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

During the first quarter of 2009, our market cap dropped below the carrying value of our net
assets due to the results of our Phase 3 trial evaluating maribavir used as prophylaxis in allogeneic stem cell or bone marrow transplant patients. We concluded that the drop in our market cap was a triggering event which required us to perform an
impairment test of our intangible assets and a step 2 test for goodwill impairment. As part of this process, we also assessed our intangible and fixed assets for impairment. Based on the analysis performed under step two, there was no remaining
implied value attributable to goodwill and accordingly, we wrote off the entire goodwill balance and recognized a goodwill impairment charge in the first quarter of 2009.



| |  |  | Short-term InvestmentsWe review our short-term investments on a periodic basis for other-than-temporary impairments. This review considers credit worthiness
and our intent and ability to hold debt securities until maturity and is subjective as it requires management to evaluate whether an event or change in circumstances has occurred in that period that may have a significant adverse effect on the fair
value of the investment.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Share-Based Employee CompensationShare based compensation is accounted for in accordance with SFAS No. 123R, Share-based Payment (SFAS 123R),
effective January 1, 2006. The calculation of this expense includes judgment related to the period of time used in calculating the volatility of our common stock, the amount of forfeitures and an estimate of the exercising habits of our
employees, which is also influenced by our Insider Trading Policy. Changes in the volatility of our common stock or the habits of our employees could result in variability in the fair value of awards granted.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Income TaxesOur annual effective tax rate is based on expected pre-tax earnings, existing statutory tax rates, limitations on the use of tax credits and net
operating loss carryforwards, evaluation of qualified expenses related to the orphan drug credit and tax planning opportunities available in the jurisdictions in which we operate. Significant judgment is required in determining our annual effective
tax rate and in evaluating our tax position.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

On a periodic basis, we evaluate the realizability of our deferred tax
assets and liabilities and will adjust such amounts in light of changing facts and circumstances, including but not limited to future projections of taxable income, tax legislation, rulings by relevant tax authorities, tax planning strategies and
the progress of ongoing tax audits. We recognize the benefit of tax positions that we have taken or expect to take on the income tax returns we file if such tax position is more likely than not of being sustained. Settlement of filing positions that
may be challenged by tax authorities could impact the income tax position in the year of resolution.

In assessing the realizability of
deferred tax assets, we consider whether it is more likely than not that some portion or all of the deferred tax assets will not be realized. The ultimate realization of deferred tax assets is dependent upon the generation of future taxable income
during the period in which those temporary differences becomes deductible or the NOLs and credit carryforwards can be utilized. When considering the reversal of the valuation allowance, we consider the level of past and future taxable income, the
reversal of deferred tax liabilities, the utilization of the carryforwards and other factors. Revisions to the estimated net realizable value of the deferred tax asset could cause our provision for income taxes to vary significantly from period to
period.



| |  |  | Acquisition AccountingBusinesses acquired before December 31, 2008 are accounted for in accordance with SFAS No. 141, Business Combinationsand the total purchase price was allocated to Levs net tangible assets or identifiable intangible assets based on their fair values as of the date of the acquisition. The application of the purchase accounting requires certain estimates
and assumptions especially concerning the determination of the fair values of the acquired intangible assets and property, plant and equipment as well as the liabilities assumed at the date of the acquisition. Moreover, the useful lives of the
acquired intangible assets, property, plant and equipment have to be determined.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Measurement of fair value and useful
lives are based to a large extent on anticipated cash flows. If actual cash flows vary from those used in calculating fair values, this may significantly affect the Companys future results of operations. In particular, the estimation of
discounted cash flows of intangible assets of newly developed products is subject to assumptions closely related to the nature of the acquired products. Factors that may affect the assumptions regarding future cash flows:



| |  |  | long-term sales forecasts,
| | - |  | --------------------------



| |  |  | anticipation of selling price erosion after the end of orphan exclusivity due to follow-on biologic competition in the market,
| | - |  | ------------------------------------------------------------------------------------------------------------------------------



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| |  |  | behavior of competitors (launch of competing products, marketing initiatives etc.).
| | - |  | -----------------------------------------------------------------------------------

For significant acquisitions, the purchase price allocation is carried out with assistance from independent third-party valuation specialists. The
valuations are based on information available at the acquisition date.



| |  |  | LegalDuring the second quarter, we began recording an allowance for rebates related to the Department of Defenses (DoDs) TRICARE Retail Pharmacy
program pursuant to a final regulation that became effective on May 26, 2009. This regulation would require manufacturers to pay rebates to DoD on product distributed to TRICARE beneficiaries through retail pharmacies retroactive to
January 28, 2008. The final regulation implements section 703 of the National Defense Authorization Act of 2008, or NDAA. The final regulation requires that pharmaceuticals paid for by the DoD through the TRICARE Retail Pharmacy program be
subject to the Federal Ceiling Price program, which will require manufacturers to provide DoD with a refund on pharmaceuticals utilized through the TRICARE Retail Pharmacy program. As permitted by the regulations, we have requested a waiver of
the retroactive rebate for TRICARE Retail Pharmacy utilization for the period from January 28, 2008 to May 26, 2009. In addition, the regulation is currently the subject to litigation and it is our belief that the retroactive
application of the regulation is contrary to established case law. We have determined that payment of the retroactive rebate created by the regulation is not probable as of June 30, 2009. Although the ultimate disposition of this matter is
uncertain, we have estimated that our maximum exposure of the retroactive rebate due to the DoD is $2.9 million.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

As our business
evolves, we may face additional issues that will require increased levels of management estimation and complex judgments.

Recently Issued Accounting
Pronouncements

In June 2009, the FASB issued Statement No. 168, The FASB Accounting Standards Codification and the Hierarchy of Generally
Accepted Accounting Principles (SFAS 168). SFAS 168 will become the single source of authoritative nongovernmental U.S. generally accepted accounting principles (GAAP), superseding existing FASB, American Institute of Certified Public
Accountants (AICPA), Emerging Issues Task Force (EITF), and related accounting literature. SFAS 168 reorganizes the thousands of GAAP pronouncements into roughly 90 accounting topics and displays them using a consistent structure. Also included is
relevant Securities and Exchange Commission guidance organized using the same topical structure in separate sections. SFAS 168 will be effective for financial statements issued for reporting periods that end after September 15, 2009. This will
have an impact on the Companys financial disclosures since all future references to authoritative accounting literature will be references in accordance with SFAS 168.

Off-Balance Sheet Arrangements

In conjunction with our acquisition of Lev, we acquired purchase obligations related
to the supply and manufacturing of Cinryze. We have committed to purchase a minimum number of liters of plasma per year through 2013 from our supplier and also have committed to purchase plasma collected from the Plasma Centers of America collection
centers unless we purchase these centers. Additionally, we are required to purchase a minimum number of units from our third party toll manufacturer. The total minimum purchase commitments for these arrangements as of June 30, 2009 are
approximately $159.0 million.



|ITEM 3. | Quantitative and Qualitative Disclosures About Market Risk
|------- | ----------------------------------------------------------

Our
holdings of financial instruments are primarily comprised of money mark funds holding only U.S. government securities. All such instruments are classified as securities available for sale. Our debt security portfolio represents funds held
temporarily pending use in our business and operations. We manage these funds accordingly. Our primary investment objective is the preservation of principal, while at the same time optimizing the generation of investment income. We seek reasonable
assuredness of the safety of principal and market liquidity by investing in cash equivalents (such as Treasury bills and money market funds) and fixed income securities (such as U.S. government and agency securities, municipal securities, taxable
municipals, and corporate notes) while at the same time seeking to achieve a favorable rate of return. Our market risk exposure consists principally of exposure to changes in interest rates. Our holdings are also exposed to the risks of changes in
the credit quality of issuers. Historically, we have typically invested in financial instruments with maturities of less than one year. The carrying amount, which approximates fair value, and the annualized weighted average nominal interest rate of
our investment portfolio at June 30, 2009, was approximately $230.2 million and 0.1%, respectively. A one percent change in the interest rate would have resulted in a $0.6 million impact to interest income for the quarter ended June 30,
2009.



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At June 30, 2009, we had principal outstanding of $205.0 million of our senior convertible notes. The senior
convertible notes bear interest at a rate of 2% per annum, payable semi-annually in arrears on March 15 and September 15 of each year commencing on September 15, 2007. The senior convertible notes are convertible into shares of
the Companys common stock at an initial conversion price of $18.87 per share. The senior convertible notes may only be converted: (i) anytime after December 15, 2016; (ii) during the five business-day period after any five
consecutive trading day period (the measurement period) in which the price per note for each trading day of that measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion
rate on each such day; (iii) during any calendar quarter (and only during such quarter) after the calendar quarter ending June 30, 2007, if the last reported sale price of our common stock for 20 or more trading days in a period of 30
consecutive trading days ending on the last trading day of the immediately preceding calendar quarter exceeds 130% of the applicable conversion price in effect on the last trading day of the immediately preceding calendar quarter; or (iv) upon
the occurrence of specified corporate events. Upon conversion, holders of the senior convertible notes will receive shares of common stock, subject to ViroPharmas option to irrevocably elect to settle all future conversions in cash up to the
principal amount of the senior convertible notes, and shares for any excess. We can irrevocably elect this option at any time on or prior to the 35th scheduled trading day prior to the maturity date of the senior convertible notes. The senior
convertible notes may be required to be repaid on the occurrence of certain fundamental changes, as defined in the senior convertible notes. As of June 30, 2009, the fair value of the principal of the $205.0 million convertible senior
notes outstanding was approximately $112.4 million, based on the level 2 valuation hierarchy under SFAS 157.

In connection with the issuance of the senior
convertible senior notes, we have entered into privately-negotiated transactions with two counterparties (the counterparties), comprised of purchased call options and warrants sold. These transactions are expected to generally reduce the
potential equity dilution of our common stock upon conversion of the senior convertible notes. These transactions expose the Company to counterparty credit risk for nonperformance. The Company manages its exposure to counterparty credit risk through
specific minimum credit standards, and diversification of counterparties.



|ITEM 4. | Controls and Procedures
|------- | -----------------------

Evaluation of Disclosure Controls and
Procedures

An evaluation was performed under the supervision and with the participation of our management, including our Chief Executive Officer, or
CEO, and our Chief Financial Officer, or CFO, of the effectiveness of our disclosure controls and procedures, as such term is defined under Rule 13a-15(e) promulgated under the Securities Exchange Act of 1934, as amended (the Exchange
Act), as of June 30, 2009. Based on that evaluation, our management, including our CEO and CFO, concluded that as of June 30, 2009 our disclosure controls and procedures were effective to ensure that information required to be
disclosed by us in reports that we file or submit under the Exchange Act, is recorded, processed, summarized and reported within the time periods specified in the rules and forms of the Securities and Exchange Commission and that such information is
accumulated and communicated to the Companys management, including our CEO and CFO, as appropriate to allow timely decisions regarding required disclosure.

Changes in Internal Control over Financial Reporting

During the second quarter of 2009 there were no significant changes in our internal
control over financial reporting identified in connection with the evaluation of such controls that occurred during our most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect our internal control over
financial reporting.



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PART II - OTHER INFORMATION



|ITEM 1A. | Risk Factors
|-------- | ------------

Our core patent protection for Vancocin has
expired, which could result in significant competition from generic products and lead to a significant reduction in sales of Vancocin.

The last core
patent protecting Vancocin expired in 1996. As a result, there is a potential for significant competition from generic products that treat the same conditions addressed by Vancocin. Such competition could result in a significant reduction in sales
of Vancocin. We believe that regulatory hurdles (notwithstanding the recent actions taken by the FDAs Office of Generic Drugs, Center for Drug Evaluation and Research (OGD), which are described in more detail below and which we are vigorously
opposing), as well as product manufacturing trade secrets, know-how and related non-patent intellectual property, may present barriers to market entry of generic competition. However, these barriers may not actually delay or prevent generic
competition. The effectiveness of these non-patent-related barriers to competition will depend primarily upon:



| |  |  | the current or future regulatory approval requirements for any generic applicant;
| | - |  | ---------------------------------------------------------------------------------



| |  |  | the complexities of the manufacturing process for a competitive product;
| | - |  | ------------------------------------------------------------------------



| |  |  | the nature of the market which Vancocin serves and the position of Vancocin in the market from time to time;
| | - |  | ------------------------------------------------------------------------------------------------------------



| |  |  | the growth of the market which Vancocin serves; and
| | - |  | ---------------------------------------------------



| |  |  | our ability to protect Vancocin know-how as a trade secret.
| | - |  | -----------------------------------------------------------

Generic competitors may take advantage of the absence of patent protection for Vancocin to attempt to develop a competing product. We have become aware of information suggesting that other potential competitors are attempting to
develop a competing generic product. For example, multiple generic manufacturers have publicly stated that they have filed to receive product approval and commence a marketing launch of a generic version of oral Vancocin. We are not able
to predict the time period in which a generic drug may enter the market, as this timing will be affected by a number of factors, including:



| |  |  | whether an in-vitro method of demonstrating bioequivalence is available to an applicant to gain marketing approval by the FDA in lieu of performing clinical
studies;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the nature of any clinical trials which are required, if any;
| | - |  | -------------------------------------------------------------



| |  |  | the timing of filing an Abbreviated New Drug Application, or an ANDA, the amount of time required by the FDA to review the ANDA and whether a generic drug
application is afforded an accelerated review by the FDA;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the specific formulation of drug for which approval is being sought; and
| | - |  | ------------------------------------------------------------------------



| |  |  | the time required to develop appropriate manufacturing procedures.
| | - |  | ------------------------------------------------------------------

On March 17, 2006, we learned that the OGD changed its approach regarding the conditions that must be met in order for a generic drug applicant to request a waiver of in-vivo bioequivalence testing for vancomycin
hydrochloride capsules. Specifically, we were informed that a generic applicant may be able to request such a waiver provided that dissolution testing demonstrates that the test product is rapidly dissolving at certain specified conditions. This
deviated from our understanding of OGDs historical practices which would require, for a poorly-absorbed, locally acting gastrointestinal drug (such as Vancocin) a demonstration of bioequivalence through clinical studies or a demonstration of
bioequivalence using an appropriately validated in-vitro methodology.

On March 17, 2006, we filed a Petition for Stay of Action with the FDA
regarding the requirements for waivers of in-vivo bioequivalence testing for Vancocin, and we have amended that petition several times through additional filings in support of our opposition to any approach that does not require rigorous scientific
methods to demonstrate a rate and extent of drug release to the site of action consistent with good medicine and science.

In December 2008, the FDA
changed OGDs 2006 bioequivalence recommendation by issuing draft guidance for establishing bioequivalence to Vancocin which would require generic products that have the same inactive ingredients in the same quantities as Vancocin, or Q1 and Q2
the same, to demonstrate bioequivalence through comparative dissolution testing. Under this latest proposed method, any generic product that is not Q1 and Q2 the same as Vancocin would need to conduct an in vivo study with clinical endpoints to
demonstrate bioequivalence with Vancocin. The FDA will convene a meeting of its Advisory Committee for Pharmaceutical Science and Clinical Pharmacology to discuss bioequivalence recommendations for oral vancomycin hydrochloride capsule drug
products. The meeting is scheduled for August 4, 2009. We have submitted briefing materials to the Advisory Committee for its consideration on the issues presented by OGDs bioequivalence recommendation, and we expect to present these
issues at the meeting. We are opposing both the substance of the FDAs bioequivalence method and the manner in which it was developed.



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##### Table of Contents

In the event the OGDs revised approach regarding the conditions that must be met in order for a generic drug
applicant to request a waiver of in-vivo bioequivalence testing for Vancocin remains in effect, the time period in which a generic competitor may enter the market would be reduced. There can be no assurance that the FDA will agree with the positions
stated in our Vancocin related submissions or that our efforts to oppose the OGDs March 2006 and December 2008 recommendation to determine bioequivalence to Vancocin through in-vitro dissolution testing will be successful. We cannot predict
the timeframe in which the FDA will make a decision regarding either our citizen petition for Vancocin or the approval of generic versions of Vancocin. If we are unable to change the recommendation set forth by the OGD in March 2006 as revised in
December 2008, the threat of generic competition will be high.

Multiple generic manufacturers have publicly stated that they have filed to receive product
approval and commence a marketing launch of a generic version of oral Vancocin. If a generic competitor or multiple generic competitors were to formulate a competing product that was approved by the FDA and that gained market acceptance, it would
have a material adverse effect on our operating results, cash flows and possibly asset valuations, on our business and our guidance.



|ITEM 4. | Submission of Matters to a Vote of Security Holders
|------- | ---------------------------------------------------

On
May 22, 2009, we held our annual stockholders meeting. In connection with the stockholders meeting, we solicited proxies for the election of Paul A. Brooke, Michael R. Dougherty and Robert J. Glaser, as our class I directors. The record date
for determining the stockholders entitled to receive notice of, and vote at, the meeting was April 3, 2009. We had 77,406,917 shares of our common stock outstanding on the record date for the meeting, of which 59,645,758 were represented at the
stockholders meeting by proxy. Such shares were voted at the stockholders meeting as follows:



|                     |  |            |  |                   
|-------------------- |  | ---------- |  | ------------------
|                     |  | FOR        |  | WITHHOLD AUTHORITY
|Paul A. Brooke       |  | 57,331,322 |  | 2,314,436         
|Michael R. Dougherty |  | 57,955,479 |  | 1,690,279         
|Robert J. Glaser     |  | 57,777,594 |  | 1,868,164         

Dr. William D. Claypool is the Class II director whose term continued after the annual meeting. John R.
Leone, Vincent J. Milano and Howard H. Pien are the Class III directors whose terms continued after the annual meeting. On June 5, 2009, the board of directors, based upon the recommendation of the boards Nominating and Corporate
Governance Committee, appointed Frank Baldino, Jr. Ph.D. to serve as a Class II director.

Additionally, we solicited proxies for (i) the
amendment and restatement of our employee stock purchase plan to increase the number of shares of common stock available for issuance under that plan by 300,000 shares and (ii) the ratification of the appointment of KPMG as the Companys
independent registered public accounting firm. Each proposal was approved as the affirmative vote of the holders of a majority of the shares represented in person or by proxy and entitled to vote on these items was required for approval. Broker
non-votes were counted solely for purposes of determining whether a quorum was present and therefore did not have an effect on these proposals. Shares were voted at the stockholders meeting on these items as follows:

Amendment Of Our Employee Stock Purchase Plan



|                  |  |           
|----------------- |  | ----------
|FOR:              |  | 38,936,698
|AGAINST:          |  | 1,234,581 
|ABSTAIN:          |  | 1,910,725 
|BROKER NON-VOTES: |  | 17,563,754

Ratification of the Appointment of KPMG as the Companys independent registered public accounting firm



|                  |  |           
|----------------- |  | ----------
|FOR:              |  | 58,824,874
|AGAINST:          |  | 664,459   
|ABSTAIN:          |  | 156,425   
|BROKER NON-VOTES: |  | 0         



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##### Table of Contents

|ITEM 6. | Exhibits
|------- | --------



|       |  |                                                                                                                                                                                                                                 
|------ |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|10.1 |  | Amended and Restated ViroPharma Incorporated 2000 Employee Stock Purchase Plan. (1)                                                                                                                                             
|       | 
|10.2 |  | Form of Amended and Restated Change of Control Agreement with the Executive Officers. (2)                                                                                                                                       
|       | 
|10.3 |  | Form of Amended and Restated Change of Control Agreement with the General Counsel. (2)                                                                                                                                          
|       | 
|10.4  |  | Intermediate Supply Agreement with Biotest AG dated as of June 19, 2009 by and between ViroPharma SPRL, a wholly owned subsidiary of ViroPharma Incorporated ,and Biotest AG. *                                                 
|       | 
|10.5  |  | Amendment to Distribution and Manufacturing Services Agreement dated as of July 18, 2009 by and between ViroPharma Biologics, Inc., a wholly owned subsidiary of ViroPharma Incorporated, and
Sanquin Blood Supply Foundation. *
|       | 
|31.1   |  | Certification by Chief Executive Officer pursuant to Rule 13a-14(a) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.*                                                                       
|       | 
|31.2   |  | Certification by Chief Financial Officer pursuant to Rule 13a-14(a) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.*                                                                       
|       | 
|32.1   |  | Certification Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                                                                                         



|(1) | Field as Annex A to the Companys Proxy Statement filed with the Commission on April 10, 2009.
|--- | ----------------------------------------------------------------------------------------------

|(2) | Filed as an Exhibit to the Companys Current Report on Form 8-K filed with the Commission on June 17, 2009.
|--- | -----------------------------------------------------------------------------------------------------------

|* | Filed herewith
|- | --------------

| | Portions of this exhibit were omitted and filed separately with the Secretary of the Commission pursuant to an application for confidential treatment filed with the Commission
pursuant to Rule 24b-2 under the Securities Exchange Act of 1934, as amended.
|- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | Compensation plans and arrangements for executives and others.
|-- | --------------------------------------------------------------



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##### Table of Contents

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.



|                    |  |                         |  |                                                                                              
|------------------- |  | ----------------------- |  | ---------------------------------------------------------------------------------------------
|                    |  | VIROPHARMA INCORPORATED
|                    |  |                        
|Date: July 29, 2009 |  | By:                     |  | /s/ Vincent J. Milano                                                                        
|                    |  |                         |  | Vincent J. Milano President and Chief Executive
Officer (Principal Executive Officer)        
|                    |  |                        
|                    |  | By:                     |  | /s/ Charles A. Rowland, Jr.                                                                  
|                    |  |                         |  | Charles A. Rowland, Jr. Vice President, Chief
Financial Officer (Principal Financial Officer)
|                    |  |                        
|                    |  | By:                     |  | /s/ Richard S. Morris                                                                        
|                    |  |                         |  | Richard S. Morris Chief Accounting Officer and
Controller (Principal Accounting Officer)     



37