Exhibit 10.21  CFO  PONIARD PHARMACEUTICALS, INC. KEY EXECUTIVE SEVERANCE AGREEMENT  This Key
Executive Severance Agreement (this Agreement), dated as of February 18,
2009, is entered into by and between PONIARD PHARMACEUTICALS, INC., a
Washington corporation (as supplemented by Section 10 hereof, the Company), and Greg
Weaver (the Executive).  The Board of
Directors of the Company (the Board) has determined that it is in the best interests
of the Company and its shareholders to ensure that the Company will have the
continued dedication of the Executive, notwithstanding the fact that the
Executive does not have any form of traditional employment contract or other
assurance of job security.  The Board
believes it is imperative to diminish any distraction of the Executive arising
from the personal uncertainty and insecurity that arises in the absence of any
assurance of job security by providing the Executive with reasonable
compensation and benefit arrangements in the event of termination of the Executives
employment by the Company under certain defined circumstances.  In order to
accomplish these objectives, the Board has caused the Company to enter into
this Agreement.  1.Term  The initial
term of this Agreement (the Initial Term) shall be for a period of one (1) year
from the date of thisAgreement
as first appearing above; provided, however, that this Agreement shall
automatically renew for successive additional one (1) year periods (Renewal Terms)
unless notice of nonrenewal is given by either party to the other party at
least nine (9) months prior to the end of the Initial Term or any Renewal
Term; and provided, further, that if a Change of Control (as defined in the
Change of Control Agreement referenced in Section 16 hereof) occurs during
the Term, the Term shall automatically extend for the duration of the
Employment Period (as defined in the Change of Control Agreement).  The Term of this Agreement shall be the Initial
Term plus all Renewal Terms and, if applicable, the duration of the Employment
Period.  At the end of the Term, this
Agreement shall terminate without further action by either the Company or the
Executive.  2.Employment at Will  The Executive
and the Company acknowledge that, except as may otherwise be provided under any
other written agreement between the Executive and the Company, the employment
of the Executive by the Company or any affiliated companies is at will and
may be terminated by either the Executive or the Company or its affiliated
companies at any time with or without cause, subject to the termination
payments prescribed herein.


3.Attention and Effort  During any
period of time that the Executive remains in the employ of the Company, and
excluding any periods of vacation and sick leave to which the Executive is
entitled, the Executive will devote all of the Executives productive time,
ability, attention and effort to the business and affairs of the Company and
the discharge of the responsibilities assigned to the Executive hereunder, and
will seek to perform faithfully and efficiently such responsibilities.  It shall not be a violation of this Agreement
for the Executive to (a) serve on corporate, civic or charitable boards or
committees, (b) deliver lectures, fulfill speaking engagements or teach at
educational institutions, (c) manage personal investments, or (d) engage
in activities permitted by the policies of the Company or as specifically
permitted by the Company, so long as such activities do not significantly
interfere with the performance of the Executives responsibilities in
accordance with this Agreement.  It is
expressly understood and agreed that to the extent any such activities have
been conducted by the Executive prior to the Term, the continued conduct of
such activities (or the conduct of activities similar in nature and scope
thereto) during the Term shall not thereafter be deemed to interfere with the
performance of the Executives responsibilities to the Company.  4.Termination  During the
Term, employment of the Executive may be terminated as follows, but, in any
case, the nondisclosure provisions set forth in Section 7 hereof shall
survive the termination of this Agreement and the termination of the
Executives employment with the Company:  4.1Termination by the Company or the
Executive  At any time
during the Term, the Company may terminate the employment of the Executive with
or without Cause (as defined below), and the Executive may terminate the
Executives employment for Good Reason (as defined below) or for any reason,
upon giving a Notice of Termination (as defined below).  4.2Automatic Termination  This Agreement
and the Executives employment during the Term shall terminate automatically
upon the death or Total Disability of the Executive.  The term Total Disability as used herein shall
mean the Executives inability (with such accommodation as may be required by
law and which places no undue burden on the Company), as determined by a
physician selected by the Company and acceptable to the Executive, to perform
the Executives essential duties for a period or periods aggregating twelve
(12) weeks in any three hundred sixty-five (365) day period as a result of
physical or mental illness, loss of legal capacity or any other cause beyond
the Executives control, unless the Executive is granted a leave of absence by
the Board.  4.3Notice of Termination  Any
termination by the Company or by the Executive during the Term shall be
communicated by a Notice of Termination to the other party given in accordance
with Section 9 hereof.  The term Notice of Termination
shall mean a written notice that (a) indicates the specific termination
provision in this Agreement relied upon and (b) to the extent applicable,
sets  2


forth in
reasonable detail the facts and circumstances claimed to provide a basis for
termination of the Executives employment under the provision so
indicated.  The failure by the Executive
or the Company to set forth in the Notice of Termination any fact or
circumstance that contributes to a showing of Good Reason or Cause shall not
waive any right of the Executive or the Company hereunder or preclude the
Executive or the Company from asserting such fact or circumstance in enforcing
the Executives or the Companys rights hereunder.  4.4Date of Termination  Date of Termination
means (a) if the Executives employment is terminated by reason of death,
the last day of the calendar month in which the Executives death occurs, (b) if
the Executives employment is terminated by reason of Total
Disability, immediately upon a determination by the Company of the
Executives Total Disability, and (c) in all other cases, ten (10) days
after the date of personal delivery or mailing of the Notice of
Termination.  The Executives employment
and performance of services will continue during such ten (10) day period;
provided, however, that the Company may, upon notice to the Executive and
without reducing the Executives compensation during such period, excuse the
Executive from any or all of the Executives duties during such period.  Notwithstanding
anything contained in this Agreement to the contrary, the date on which a
separation from service (Separation
from Service)
pursuant to Section 409A of the Internal Revenue Code of 1986, as amended
(Code Section 409A),
occurs shall be the Date of Termination or termination of employment for
purposes of determining the timing of payments under this Agreement to the
extent necessary to have such payments and benefits under this Agreement be
exempt from the requirements of Code Section 409A or comply with the
requirements of Code Section 409A.  5.Termination Payments  In the event
of termination of the Executives employment during the Term, all compensation
and benefits shall terminate, except as specifically provided in this Section 5.  5.1Termination by the Company Other
Than for Cause or by the Executive for Good Reason  If during the
Term the Company terminates the Executives employment other than for Cause or
the Executive terminates the Executives employment for Good Reason, the
Executive shall be entitled to:  (a)receive
payment of the following accrued obligations (the Accrued Obligations):  (i)the
Executives then current annual base salary through the Date of Termination to
the extent not theretofore paid;  (ii)any
compensation previously deferred by the Executive (together with accrued
interest or earnings thereon, if any); and  (iii)any
accrued vacation pay that would be payable under the Companys standard policy,
in each case to the extent not theretofore paid;  3


(b)have
the Company pay for nine (9) months after the Date of Termination or until
the Executive qualifies for comparable medical and dental insurance benefits
from another employer, whichever occurs first, the Executives premiums for
health insurance benefit continuation for the Executive and the Executives
family members, if applicable, that the Company provides to the Executive under
the provisions of the federal Consolidated Omnibus Budget Reconciliation Act of
1985, as amended (COBRA),
to the extent that the Company would have paid such premiums had the Executive
remained employed by the Company (such continued payment is hereinafter
referred to as COBRA
Continuation); and  (c)an
amount as severance pay equal to seventy-five percent (75%) of the Executives
then current annual base salary for the fiscal year in which the Date of
Termination occurs, subject to payment as set forth in Sections 5.5 and
5.9 hereof.  5.2Termination for Cause or Other
Than for Good Reason  If during the
Term the Executives employment shall be terminated by the Company for Cause or
by the Executive for other than Good Reason, this Agreement shall terminate
without further obligation on the part of the Company to the Executive, other
than the Companys obligation to pay the Executive the Accrued Obligations to
the extent theretofore unpaid.  5.3Expiration of Term  In the event
the Executives employment is not terminated prior to expiration of the Term,
this Agreement shall terminate without further obligation on the part of the
Company to the Executive.  5.4Termination Because of Death or
Total Disability  If during the
Term the Executives employment is terminated by reason of the Executives
death or Total Disability, this Agreement shall terminate automatically without
further obligation on the part of the Company to the Executive or the
Executives legal representatives under this Agreement, other than the
Companys obligation to pay the Executive the Accrued Obligations (which shall
be paid to the Executives estate or beneficiary, as applicable in the case of
the Executives death) and to provide COBRA Continuation.  5.5Payment Schedule  All payments
of Accrued Obligations, or any portion thereof payable pursuant to this Section 5,
other than deferred compensation pursuant to Section 5.1(a)(ii) hereof,
shall be made to the Executive within ten (10) working days of the Date of
Termination.  Deferred compensation
pursuant to Section 5.1(a)(ii) hereof shall be payable pursuant to
the terms of the deferred compensation program. 
Any severance payments payable to the Executive pursuant to Section 5.1(c) shall
be made to the Executive in the form of salary continuation, payable at normal
payroll intervals during the nine (9) month period following the Date of
Termination.  Notwithstanding the
preceding provisions of this Section 5, if any payment or benefit pursuant
to this Agreement constitutes a deferral of compensation subject to Code Section 409A
(after taking into account, to the maximum extent possible, any applicable
exemptions) (a 409A Payment) treated as
payable to a Specified Employee (as defined in Section 20.1 hereof) upon  4


Separation
from Service, the provisions of Section 20.1 hereof shall apply.  Section 5.8 hereof must be satisfied to
receive payments and benefits under this Agreement.  5.6Cause  For purposes
of this Agreement, Cause
means cause given by the Executive to the Company and shall include, without
limitation, the occurrence of one (1) or more of the following events:  (a)a
clear refusal to carry out any material lawful duties of the Executive or any
directions of the Board or senior management of the Company reasonably
consistent with those duties;  (b)persistent
failure to carry out any lawful duties of the Executive or any directions of
the Board or senior management reasonably consistent with those duties;
provided, however, that the Executive has been given reasonable notice and
opportunity to correct any such failure;  (c)violation
by the Executive of a state or federal criminal law involving the commission of
a crime against the Company or any other criminal act involving moral turpitude;  (d)current
abuse by the Executive of alcohol or controlled substances; deception, fraud,
misrepresentation or dishonesty by the Executive; or any incident materially
compromising the Executives reputation or ability to represent the Company
with investors, customers or the public; or  (e)any
other material violation of any provision of this Agreement by the Executive,
subject to the notice and opportunity-to-cure requirements of Section 8
hereof.  5.7Good Reason  For purposes
of this Agreement, Good
Reason means:  (a)material
reduction of the Executives annual base salary to a level below the level in
effect on the date of this Agreement, regardless of any change in the
Executives duties or responsibilities;  (b)the
assignment to the Executive of any duties materially inconsistent with the
Executives position, authority, duties or responsibilities or any other action
by the Company that results in a material diminution in such position,
authority, duties or responsibilities, excluding for this purpose an isolated
and inadvertent action not taken in bad faith and that is remedied by the
Company promptly after receipt of notice thereof given by the Executive;  (c)the
Companys requiring the Executive to be based at any office or location more
than fifty (50) miles from the cities in which the Executive will be employed
by the Company, i.e., both San Francisco, California and Seattle, Washington;  5


(d)any
failure by the Company to comply with and satisfy Section 10 hereof;
provided, however, that the Companys successor has received at least ten (10) days
prior written notice from the Company or the Executive of the requirements of Section 10
hereof; or  (e)any
other material violation of any provision of this Agreement by the Company;  provided, however, that the Executive has notified the
Company of such salary reduction, assignment, failure, situation or violation
within ninety (90) days of its occurrence and there has been compliance with
the notice and opportunity-to-cure requirements of Section 8 hereof.  5.8General Release of Claims  As a condition
to receiving the payments and benefits under this Section 5 other than
Accrued Obligations set forth in Sections 5.1(a)(i) and 5.1(a)(iii) hereof,
the Executive shall execute (and not later revoke) a general release and waiver
of all claims against the Company, which release and waiver shall be in a form
satisfactory to the Company, in its sole discretion, and delivered to the
Company no later than the seventh day of the third month of the fiscal year
following the year in which the Date of Termination occurs.  By way of example and not limitation, the
general release and waiver of claims will include any claims for wages,
bonuses, employment benefits, or damages of any kind whatsoever, arising out of
any contracts, express or implied, any covenant of good faith and fair dealing,
express or implied, any theory of wrongful discharge, any legal restriction on
the Companys right to terminate employment, or any federal, state or other
governmental statute or ordinance, including, without limitation, Title VII of
the Civil Rights Act of 1964, the federal Age Discrimination in Employment Act,
the Americans with Disabilities Act, the Family and Medical Leave Act, the
Washington Law Against Discrimination, or any other legal limitation on the
employment relationship.  To the extent
any payment or benefit is a 409A Payment, the provisions of Section 20.3
hereof shall apply.  5.9Dispute Regarding Existence of Good
Reason for Termination  In the event
the Company disputes whether Good Reason existed for the Executive to terminate
the Executives employment for Good Reason, the Company shall pay salary
continuation as provided in Section 5.5 until the earliest of (a) settlement
by the parties, (b) determination by arbitration in accordance with Section 14
hereof that Good Reason did not exist, and (c) completion of the payments
required by Section 5.5 and Section 5.1(c) hereof.  If, pursuant to Section 14 hereof, an
arbitrator determines that Good Reason did not exist, the arbitrator shall also
decide whether the Executive had a reasonable, good-faith basis for claiming
that there was Good Reason to terminate. 
If the arbitrator determines that there was not such a basis, the
Executive shall be obligated to repay promptly to the Company the salary
continuation payments; if the arbitrator determines that there was such a
basis, the Executive shall not be obligated to repay the salary continuation.  6.Representations, Warranties and
Other Conditions  In order to
induce the Company to enter into this Agreement, the Executive represents and
warrants to the Company as follows:  6


6.1Health  The Executive
is in good health and knows of no physical or mental disability that, with any
accommodation that may be required by law and that places no undue burden on
the Company, would prevent the Executive from fulfilling the Executives obligations
hereunder.  The Executive agrees, if the
Company requests, to submit to reasonable periodic medical examinations by a
physician or physicians designated by, paid for and arranged by the Company.  The Executive agrees that each examinations
medical report shall be provided to the Company.  6.2No Violation of Other Agreements  The Executive
represents that neither the execution nor the performance of this Agreement by
the Executive will violate or conflict in any way with any other agreements or
obligations by which the Executive may be bound.  7.Nondisclosure; Return of
Materials  7.1Nondisclosure  Except as
required by the Executives employment with the Company, the Executive will
not, at any time during the term of employment by the Company, or at any time
thereafter, directly, indirectly or otherwise, use, communicate, disclose,
disseminate, lecture upon or publish articles relating to any confidential,
proprietary or trade secret information of the Company without the prior
written consent of the Company.  The
Executive understands that the Company will be relying on this Agreement in
continuing the Executives employment, paying the Executives compensation,
granting the Executive any promotions or raises, or entrusting the Executive
with any information that helps the Company compete with others.  7.2Return of Materials  All documents,
records, notebooks, notes, memoranda, drawings or other documents made or
compiled by the Executive at any time while employed by the Company, or in the
Executives possession, including any and all copies thereof, shall be the
property of the Company and shall be held by the Executive in trust and solely
for the benefit of the Company, and shall be delivered to the Company by the
Executive upon termination of employment or at any other time upon request by
the Company.  8.Notice and Cure of Breach  Whenever a
breach of this Agreement by either party is relied upon as justification for
any action taken by the other party pursuant to any provision of this Agreement,
other than clause (a), (b), (c) or (d) of Section 5.6
hereof, before such action is taken, the party asserting the breach of this
Agreement shall give the other party at least twenty (20) days prior written
notice of the existence and the nature of such breach before taking further
action hereunder and shall give the party purportedly in breach of this
Agreement the opportunity to correct such breach during the twenty (20) day
period.  7


9.Form of Notice  Every notice
required by the terms of this Agreement shall be given in writing by serving
the same upon the party to whom it was addressed personally or by registered or
certified mail, return receipt requested, at the address set forth below or at
such other address as may hereafter be designated by notice given in compliance
with the terms hereof:  If to the Executive:
  Greg Weaver9129 143rd Avenue SENewcastle, Washington
  98059If to the Company:
  Poniard Pharmaceuticals, Inc.300 Elliott Avenue West, Suite 500Seattle, Washington 98119Attn: Chief Executive OfficerWith a copy to:
  Perkins CoieLLP1201 Third Avenue, Suite 4800Seattle, Washington 98101-3099Attn: James R. Lisbakken  Except as set forth in Section 4.4 hereof,
if notice is mailed, such notice shall be effective upon mailing.  10.Assignment  This Agreement
is personal to the Executive and shall not be assignable by the Executive.  The Company
shall assign to and require any successor (whether direct or indirect, by
purchase, merger, consolidation or otherwise) to all or substantially all the
business and/or assets of the Company to assume expressly and agree to perform
this Agreement in the same manner and to the same extent that the Company would
be required to perform it if no such succession had taken place.  As used in this Agreement, Company shall mean
Poniard Pharmaceuticals, Inc. and any affiliated company or successor to
its business and/or assets as aforesaid that assumes and agrees to perform this
Agreement by contract, operation of law or otherwise; and as long as such
successor assumes and agrees to perform this Agreement, the termination of the
Executives employment by one such entity and the immediate hiring and
continuation of the Executives employment by the succeeding entity shall not
be deemed to constitute a termination or trigger any severance obligation under
this Agreement.  All the terms and
provisions of this Agreement shall be binding upon and inure to the benefit of
and be enforceable by the parties hereto and their respective successors and
permitted assigns.  11.Waivers  No delay or
failure by any party hereto in exercising, protecting or enforcing any of its
rights, titles, interests or remedies hereunder, and no course of dealing or
performance with respect thereto, shall constitute a waiver thereof.  The express waiver by a party hereto of any  8


right, title,
interest or remedy in a particular instance or circumstance shall not
constitute a waiver thereof in any other instance or circumstance.  All rights and remedies shall be cumulative
and not exclusive of any other rights or remedies.  12.Amendments in Writing  No amendment,
modification, waiver, termination or discharge of any provision of this
Agreement, or consent to any departure therefrom by either party hereto, shall
in any event be effective unless the same shall be in writing, specifically
identifying this Agreement and the provision intended to be amended, modified, waived,
terminated or discharged and signed by the Company and the Executive, and each
such amendment, modification, waiver, termination or discharge shall be
effective only in the specific instance and for the specific purpose for which
given.  No provision of this Agreement
shall be varied, contradicted or explained by any oral agreement, course of
dealing or performance or any other matter not set forth in an agreement in
writing and signed by the Company and the Executive.  13.Applicable Law  This Agreement
shall in all respects, including all matters of construction, validity and
performance, be governed by, and construed and enforced in accordance with, the
laws of the State of Washington, without regard to any rules governing
conflicts of laws.  14.Arbitration; Attorneys Fees  Except in
connection with enforcing Section 7 hereof, for which legal and equitable
remedies may be sought in a court of law, any dispute arising under this
Agreement shall be subject to arbitration. 
The arbitration proceeding shall be conducted in accordance with the
Commercial Arbitration Rules of the American Arbitration Association (the AAA Rules) then in
effect, conducted by one (1) arbitrator either mutually agreed upon or
selected in accordance with the AAA Rules. 
The arbitration shall be conducted in King County, Washington, under the
jurisdiction of the Seattle office of the American Arbitration
Association.  The arbitrator shall have
authority only to interpret and apply the provisions of this Agreement, and
shall have no authority to add to, subtract from or otherwise modify the terms
of this Agreement.  Any demand for
arbitration must be made within sixty (60) days of the event(s) giving
rise to the claim that this Agreement has been breached.  The arbitrators decision shall be final and
binding, and each party agrees to be bound by the arbitrators award, subject
only to an appeal therefrom in accordance with the laws of the State of
Washington.  Either party may obtain
judgment upon the arbitrators award in the Superior Court of King County,
Washington.  If it becomes
necessary to pursue or defend any legal proceeding, whether in arbitration or
court, in order to resolve a dispute arising under this Agreement, the
prevailing party in any such proceeding shall be entitled to recover its
reasonable costs and attorneys fees.  To
the extent necessary to prevent the Executive from being subject to any
additional tax pursuant to Code Section 409A(a)(1)(B), any amounts payable
to the Executive pursuant to this paragraph shall be paid in no event later
than the year following the year during which such costs and fees were
incurred.  9


15.Severability  If any
provision of this Agreement shall be held invalid, illegal or unenforceable in
any jurisdiction, for any reason, including, without limitation, the duration
of such provision, its geographical scope or the extent of the activities
prohibited or required by it, then, to the full extent permitted by law, (a) all
other provisions hereof shall remain in full force and effect in such
jurisdiction and shall be liberally construed in order to carry out the intent
of the parties hereto as nearly as may be possible, (b) such invalidity,
illegality or unenforceability shall not affect the validity, legality or
enforceability of any other provision hereof, and (c) any court or
arbitrator having jurisdiction thereover shall have the power to reform such
provision to the extent necessary for such provision to be enforceable under
applicable law.  16.Coordination With Change of
Control Agreement  Contemporaneously
with this Agreement, the Company and the Executive are entering into a Change
of Control Agreement (the Change
of Control Agreement), which agreement provides for certain forms
of severance and benefit payments in the event of termination of the Executives
employment under certain defined circumstances. 
This Agreement is in addition to the Change of Control Agreement,
providing certain assurances to the Executive in circumstances that the Change
of Control Agreement does not cover, and in no way supersedes or nullifies the
Change of Control Agreement. 
Nevertheless, it is possible that a termination of employment by the
Company or by the Executive may fall within the scope of both agreements.  In such event, payments made to the Executive
under Section 5.1 hereof shall be coordinated with payments made to the
Executive under Section 8.1 of the Change of Control Agreement as follows:  (a)Accrued
Obligations under this Agreement need not be paid if paid under the Change of
Control Agreement;  (b)COBRA
Continuation under this Agreement need not be provided if provided under the
Change of Control Agreement; and  (c)the
severance payment required under Section 5.1(c) hereof (and paid
pursuant to Section 5.5 hereof) need not be paid to the extent a severance
payment is made under Section 8.1(d) of the Change of Control
Agreement in connection with a Change of Control under the Change of Control
Agreement that constitutes a change in the ownership or effective control of
the Company or in the ownership of a substantial portion of the assets of the
Company within the meaning of subsection (a)(2)(A)(v) of Code Section 409A,
i.e., the credit from Section 8.1(d) of the Change of Control
Agreement is applied as amounts become due under Section 5.5 hereof.  17.Excess Parachute Payments  Unless
provided by Section 8.8 of the Change of Control Agreement, if any portion
of the payments or benefits under this Agreement or any other agreement or
benefit plan of the Company (including stock options) would be characterized as
an excess parachute payment to the Executive under Section 280G of the
Internal Revenue Code of 1986, as amended (the Code), the Executive shall be paid any
excise tax that the Executive owes under Code Section 4999 as a result of
such characterization, such excise tax to be paid to the Executive at  10


least ten (10) days
prior to the date that the Executive is obligated to make the excise tax
payment.  The determination of whether
and to what extent any payments or benefits would be excess parachute payments
and the date by which any excise tax shall be due shall be determined in
writing by recognized tax counsel selected by the Company and reasonably
acceptable to the Executive.  Without
limitation on the foregoing, the payments made pursuant to this Section 17
shall be made no later than the end of the year following the year in which the
Executive remits such excise tax to the Internal Revenue Service.  18.Entire Agreement  Except as
described in Section 16 hereof, this Agreement constitutes the entire
agreement between the Company and the Executive with respect to the subject
matter hereof, and all prior or contemporaneous oral or written communications,
understandings or agreements between the Company and the Executive with respect
to such subject matter are hereby superseded and nullified in their entireties,
except that the Proprietary Information and Invention Agreement between the
Executive and the Company shall continue in full force and effect to the extent
not superseded by Section 7 hereof.  19.Withholding  The Company
may withhold from any amounts payable under this Agreement such federal, state
or local taxes as shall be required to be withheld pursuant to any applicable
law or regulation.  20.409A Interpretation Provision  The parties
intend that this Agreement and the payments and benefits provided hereunder be
exempt from the requirements of Code Section 409A to the maximum extent
possible, whether pursuant to the short-term deferral exception described in
Treasury Regulation Section 1.409A-1(b)(4), the involuntary separation pay
plan exception described in Treasury Regulation Section 1.409A-1(b)(9)(iii),
or otherwise.  To the extent Code Section 409A
is applicable to this Agreement, the parties intend that this Agreement comply
with the deferral, payout and other limitations and restrictions imposed under
Code Section 409A.  Notwithstanding
anything herein to the contrary, this Agreement is intended to be interpreted
and operated to the fullest extent possible so that the payments and benefits
under this Agreement either shall be exempt from the requirements of  Code Section 409A or shall comply with
the requirements of such provision; provided, however, that notwithstanding
anything to the contrary in this Agreement in no event shall the Company be
liable to the Executive for or with respect to any taxes, penalties or interest
that may be imposed upon the Executive pursuant to Code Section 409A.  20.1Payments to Specified Employees  To the extent
that any payment or benefit pursuant to this Agreement constitutes a 409A
Payment treated as payable upon Separation from Service, then, if on the date
of the Executives Separation from Service, the Executive is a Specified
Employee, then to the extent required for the Executive not to incur additional
taxes pursuant to Code Section 409A, no such 409A Payment shall be made to
the Executive earlier than the earlier of (a) six (6) months after
the Executives Separation from Service or (b) the date of the Executives
death.  Should this Section  11


20 result in
the delay of benefits, any such benefit shall be made available to the
Executive by the Company during such delay period at the Executives
expense.  Should this Section 20.1
result in a delay of payments or benefits to the Executive, on the first day
any such payments or benefits may be made without incurring additional tax
pursuant to Code Section 409A (409A Payment Date),
the Company shall make such payments and provide such benefits as provided for
in this Agreement, provided that any amounts that would have been payable
earlier but for the application of this Section 20.1 as well as
reimbursement of the amount the Executive paid for benefits pursuant to the
preceding sentence, shall be paid in a lump sum on the 409A Payment Date.  For purposes of this Section 20.1, the
term Specified Employee shall
have the meaning set forth in Code Section 409A, as determined in
accordance with the methodology established by the Company.  20.2Reimbursements  For purposes
of complying with Code Section 409A and without extending the payment
timing otherwise provided in this Agreement, taxable reimbursements under this
Agreement, subject to the following sentence and to the extent required to
comply with Code Section 409A, will be made no later than the end of the
calendar year following the calendar year the expense was incurred.  To the extent required to comply with Code Section 409A,
any taxable reimbursements and any in-kind benefit under this Agreement will be
subject to the following:  (a) payment
of such reimbursements or in-kind benefits during one calendar year will not
affect the amount of such reimbursements or in-kind benefits provided during
any other calendar year (other than for medical reimbursement arrangements as
excepted under Treasury Regulation Section 1.409A-3(i)(1)(iv)(B) solely
because the arrangement provides for a limit on the amount of expenses that may
be reimbursed under such arrangement over some or all of the period the
arrangement remains in effect); (b) such right to reimbursements or
in-kind benefits is not subject to liquidation or exchange for another form of
compensation to the Executive; and (c) the right to reimbursements under
this Agreement will be in effect for the lesser of the time specified in this
Agreement or ten (10) years plus the lifetime of the Executive.  Any taxable reimbursements or in-kind
benefits shall be treated as not subject to Code Section 409A to the
maximum extent provided by Treasury Regulation Section 1.409A-1(b)(9)(v) or
otherwise under Code Section 409A.  20.3Release  Subject to Section 20.1
hereof, (a) to the extent that the Executive is required to execute and
deliver a release to receive a 409A Payment and (b) this Agreement
provides for such 409A Payment to be provided prior to the 55th day following
the Executives Separation from Service, such 409A Payment will be provided
upon the 55th day following the Executives Separation from Service, provided
that the release in the form acceptable to the Company, in its sole discretion,
has been executed, delivered and effective prior to such time.  To the extent there is a delay in providing a
409A Payment because of the provisions of this Section 20.3, interest for
the delay and the opportunity for the Executive to pay for benefits in the
interim with subsequent reimbursement from the Company shall be provided in a
manner consistent with that set forth in Section 20.1 hereof.  If a release is required for a 409A Payment
and such release is not executed, delivered and effective by the 55th day
following the Executives Separation from  12


Service, such
409A Payment shall not be provided to the Executive to the extent that
providing such 409A Payment would cause such 409A Payment to fail to comply
with Code Section 409A.  20.4No Acceleration; Separate
Payments  No 409A
Payment payable under this Agreement shall be subject to acceleration or to any
change in the specified time or method of payment, except as otherwise provided
under this Agreement and consistent with Code Section 409A.  If under this Agreement, a 409A Payment is to
be paid in two (2) or more installments, for purposes of Section 409A,
each installment shall be treated as a separate payment.  21.Counterparts  This Agreement
may be executed in counterparts, each of which counterpart shall be deemed an
original, but all of which together shall constitute one and the same
instrument.  IN WITNESS
WHEREOF, the parties have executed and entered into this Agreement effective on
the date first set forth above.   PONIARD PHARMACEUTICALS, INC.By:
  /s/ Anna Lewak WightName:
  Anna Lewak WightIts:
  Vice President, LegalEXECUTIVEBy:
  /s/ Greg WeaverName:
  Greg Weaver  13