Exhibit 10.1

LEASE FOR COMBINATION

OFFICE/WAREHOUSE

AT

EAGLEVIEW CORPORATE
CENTER

730 STOCKTON DRIVE

LOT NO. 10

LANDLORD: 730 STOCKTON DRIVE ASSOCIATES, L.P.

TENANT: VIROPHARMA INCORPORATED



---

TABLE OF CONTENTS



|    |  |                                                               |  |     
|--- |  | ------------------------------------------------------------- |  | ----
|    |  |                                                               |  | Page
|1.  |  | LEASED SPACE AND PURPOSE                                      |  | 1   
|    |  |                                                              
|2.  |  | TERM                                                          |  | 1   
|    |  |                                                              
|3.  |  | RENT                                                          |  | 2   
|    |  |                                                              
|4.  |  | ADDITIONAL RENT                                               |  | 6   
|    |  |                                                              
|5.  |  | NEGATIVE COVENANTS OF TENANT: HAZARDOUS SUBSTANCES            |  | 7   
|    |  |                                                              
|6.  |  | LATE PAYMENT                                                  |  | 9   
|    |  |                                                              
|7.  |  | CONSTRUCTION OF LEASED SPACE                                  |  | 9   
|    |  |                                                              
|8.  |  | TENANTS ALTERATIONS                                          |  | 10  
|    |  |                                                              
|9.  |  | MECHANICS LIENS                                              |  | 12  
|    |  |                                                              
|10. |  | CONDITION OF LEASED SPACE                                     |  | 12  
|    |  |                                                              
|11. |  | BUILDING SERVICES                                             |  | 12  
|    |  |                                                              
|12. |  | ASSIGNMENT AND SUBLETTING                                     |  | 13  
|    |  |                                                              
|13. |  | ACCESS TO LEASED SPACE                                        |  | 14  
|    |  |                                                              
|14. |  | REPAIRS                                                       |  | 15  
|    |  |                                                              
|15. |  | TERMINATION AND EXTENSION                                     |  | 16  
|    |  |                                                              
|16. |  | SURRENDER OF LEASED SPACE                                     |  | 16  
|    |  |                                                              
|17. |  | INDEMNIFICATION AND INSURANCE                                 |  | 17  
|    |  |                                                              
|18. |  | FIRE OR OTHER CASUALTY                                        |  | 18  
|    |  |                                                              
|19. |  | CONDEMNATION                                                  |  | 19  
|    |  |                                                              
|20. |  | ESTOPPEL CERTIFICATES                                         |  | 20  
|    |  |                                                              
|21. |  | DEFAULT                                                       |  | 20  
|    |  |                                                              
|22. |  | REMEDIES                                                      |  | 21  
|    |  |                                                              
|23. |  | CONFESSION OF JUDGMENT FOR POSSESSION IN LIMITED CIRCUMSTANCE |  | 23  
|    |  |                                                              
|24. |  | WAIVER                                                        |  | 23  
|    |  |                                                              
|25. |  | QUIET ENJOYMENT                                               |  | 24  
|    |  |                                                              
|26. |  | FORCE MAJEURE                                                 |  | 24  
|    |  |                                                              
|27. |  | SUCCESSORS                                                    |  | 24  
|    |  |                                                              
|28. |  | LANDLORDS LIABILITY                                          |  | 24  
|    |  |                                                              
|29. |  | SUBORDINATION                                                 |  | 25  



---

|    |  |                                             |  |   
|--- |  | ------------------------------------------- |  | --
|    |  |                                            
|30. |  | RULES AND REGULATIONS                       |  | 25
|    |  |                                            
|31. |  | GOVERNING LAW                               |  | 25
|    |  |                                            
|32. |  | SEVERABILITY                                |  | 25
|    |  |                                            
|33. |  | NOTICES                                     |  | 26
|    |  |                                            
|34. |  | BROKERS                                     |  | 26
|    |  |                                            
|35. |  | SIGNS                                       |  | 27
|    |  |                                            
|36. |  | SECURITY DEPOSIT; SECURITY INTEREST         |  | 27
|    |  |                                            
|37. |  | USE OF INFORMATION IN ADVERTISING           |  | 28
|    |  |                                            
|38. |  | CAPTIONS                                    |  | 28
|    |  |                                            
|39. |  | ENTIRE AGREEMENT                            |  | 28
|    |  |                                            
|40. |  | ACCESS TO THE LEASED SPACE AND COMMON AREAS |  | 28
|    |  |                                            
|41. |  | ATTORNEY FEES                               |  | 28
|    |  |                                            
|42. |  | SELF-HELP                                   |  | 29
|    |  |                                            
|43. |  | MEMORANDUM OF LEASE                         |  | 29
|    |  |                                            
|44. |  | LANDLORD REPRESENTATIONS AND WARRANTIES.    |  | 30
|    |  |                                            
|45. |  | RENEWAL OPTION.                             |  | 32
|    |  |                                            
|46. |  | EXPANSION OPTION FOR ADJACENT BUILDINGS     |  | 34
|    |  |                                            
|47. |  | LANDLORDS SUBORDINATION.                   |  | 36



|                                         
|-----------------------------------------
|EXHIBITS                                 
|                                         
|A  Description of Leased Space          
|B  Work Letter                          
|C  INTENTIONALLY OMITTED                
|D  Janitorial Specifications            
|E  Rules and Regulations                
|F  Permitted Title Exceptions           
|G  Plan Depicting Adjacent Land Building
|H  Approved Lot 10 Land Development Plan



---

LEASE

LEASE is made this 14thday of March, 2008 between 730 STOCKTON DRIVE ASSOCIATES, L.P., a Pennsylvania limited partnership (Landlord), with its office at Eagleview Corporate Center, 707 Eagleview Boulevard, P.O. Box 562, Exton,
Pennsylvania 19341, and VIROPHARMA INCORPORATED, a Pennsylvania corporation (Tenant), with its office at 397 Eagleview Boulevard, Exton, Pennsylvania 19341.

1. LEASED SPACE AND PURPOSE.

(a) Landlord hereby rents to Tenant all that certain space
described below (collectively Leased Space), Lot No. 10, 730 Stockton Drive, within the Center known as Eagleview Corporate Center, Upper Uwchlan Township, Chester County, Pennsylvania, which shall include all space
within the 78,264 square foot, single story building constructed by Landlord (the Building) on the 8.628 +/- acre parcel of land shown on the site plan attached hereto as Exhibit A (the Land), and
(b) the interior improvements to be constructed by Landlord in the Building, together with all fixtures, improvements, additions and other property installed therein as the same may be modified in accordance with the provisions of this Lease.
The Leased Space includes all fixtures, improvements, additions and other property installed therein at the Commencement Date (hereafter defined), or at any time during the term of this Lease (other than Tenants movable personal property and
trade fixtures), together with the right to use, in common with others, the parking lot and all other public portions of the Center.

(b)
The Leased Space shall be used and occupied as a general office space, in connection with Tenants Business (hereafter defined), which may include the incidental handling of pharmaceutical products and chemicals used in such products and for no
other purpose. For purposes hereof, Tenants Business shall be deemed to be the development and commercialization of pharmaceutical products.

2. TERM.

(a) The term of this Lease and Tenants obligation to pay rent hereunder shall commence upon a date
(Commencement Date) which is the earlier of.

(i) the date when the Leased Space is ready for
occupancy; or

(ii) the date when Tenant shall take possession of the Leased Space other than to complete installation
of Tenants Work (as defined in the Work Letter).

(b) The Leased Space shall be deemed ready for occupancy when Landlord
has Substantially Completed the Landlords Work described in the Work Letter attached hereto as Exhibit B (Work Letter). Substantial Completion or Substantially Completed
shall mean such completion as shall enable Tenant to reasonably and conveniently use and occupy the Leased Space for the conduct of Tenants Business. Substantial Completion shall be deemed to



1



---

have been achieved even though minor or insubstantial details of construction, mechanical adjustment or decoration remain to be performed, the non-completion
of which does not materially interfere with Tenants use of the Leased Space, installation of finishing work or the conduct of Tenants Business therein. In no event, however, shall Substantial Completion be deemed to have occurred prior
to (A) the issuance of a permanent certificate of occupancy for the Leased Space by the municipality, and (B) the issuance of a certificate of substantial completion by Landlords general contractor which is verified by Tenants
Consultant (as defined in the Work Letter); provided that any disagreement as to whether Substantial Completion has occurred shall be settled in the manner provided in the Work Letter. If the Commencement Date does not occur within twenty-two
(22) weeks after issuance of approved construction documents and a building permit for Landlords Work, as such period may be extended for Tenant Delays (the Outside Delivery Date), Tenant may elect to terminate this Lease by
written notice delivered to Landlord within five (5) days following the Outside Delivery Date, in which event neither party shall have any further rights or obligations hereunder, except that the Security Deposit, the Reservation Fee and any
other amounts paid by Tenant pursuant to this Lease shall be returned by Landlord to Tenant within thirty (30) days of such termination.

(c) Tenant shall execute and deliver to Landlord a declaration of the Commencement Date upon presentation by Landlord prior to taking occupancy. The term (Term) of this Lease shall end seven (7) years six (6) months
after the Commencement Date unless sooner terminated or renewed in accordance with this Lease; provided, however, that if the Commencement Date is not the first day of a calendar month, the Term shall extend to the last day of the calendar month
which is seven (7) years six (6) months after the Commencement Date occurs. Such seven (7) year six (6) month period is sometimes referred to herein as Initial Term.

3. RENT.

(a) Definitions.

(i) Tenant and Landlord acknowledge and agree that the rentable area of the Building and Leased Space will be 78,264 square feet and
Tenants Proportionate Share shall be 100%.

(ii) Real Estate Taxes shall mean all taxes and assessments
levied, assessed or imposed at any time by any governmental authority upon or against the Building and the land upon which the Building is situate, and also any tax or assessment levied, assessed or imposed at any time by any governmental authority
in connection with the receipt of income or rents from said Building or land to the extent that the same shall be in lieu of (and/or in lieu of an increase in) all or a portion of any of the aforesaid taxes or assessments upon or against the said
Building and/or land. If, however, any assessment included within Real Estate Taxes is payable in installments extending beyond the term of this Lease, Tenant shall only be obligated to pay those installments coming due during the term of this
Lease. Real Estate Taxes shall not include any penalty or interest as a result of Landlords late payment. Landlord further agrees to make payment of Real Estate Taxes in a timely manner so as to take advantage of any applicable
discount and to provide to Tenant copies of receipts for paid Real Estate Taxes not later than



2



---

thirty (30) days after the Real Estate Taxes are due. Failure of Landlord to provide such receipts to Tenant shall permit Tenant to suspend payment of
Tenants Proportionate Share of Real Estate Taxes until such receipts are furnished to Tenant.

At any time and from time to time
during the term of this Lease, Tenant, at its expense, shall have the right to institute proceedings challenging the amount of Real Estate Taxes. Landlord agrees to reasonably cooperate with Tenant in connection therewith. Any refund awarded shall
be reimbursed first to each party in proportion to the expenses incurred by such party in prosecuting such appeal, with any balance thereof next being refunded to Tenant in an amount equal to Tenants Proportionate Share of (A) the balance
of such award remaining after the foregoing cost reimbursements (B) multiplied by a fraction (1) the numerator of which shall be the number of days during the tax year for which the refund is awarded for which Tenant has paid Real Estate
Taxes pursuant to this Lease and (2) the denominator of which is 365.

Operating Expenses shall mean that part of any and
all expenses reasonably and actually incurred by Landlord in connection with its ownership, maintenance and operation of the Building, the land upon which the Building is situate, excluding Real Estate Taxes and interest or amortization payments on
any mortgage, but including, without limitation, electricity (other than as billed directly to Tenant based on usage); insurance maintained on the Building in accordance herewith; all direct and indirect labor costs; a management fee not exceeding
four percent (4%) of the aggregate Minimum Annual Rent and Real Estate Taxes and Operating Expenses (Management Fee); legal expenses; service contracts and supplies used in connection with the cleaning, operating, labor and
maintenance of the Building; all repairs and decorating required to be performed by Landlord as provided for in this Lease (other than Landlords Work as defined herein); common area maintenance and snow removal; building supplies,
equipment, purchases of goods and services which are expensed, rather than capitalized under generally accepted accounting principles (GAAP); all charges for the common areas of the Building for electricity and all charges for the entire
Building for water and sewer service, including any taxes on such utilities, removal of trash, rubbish, garbage and refuse; the cost of operating an identification sign or signs for the Building; replacing of paving, curbs, walkways, directional or
other signs; drainage; maintenance and monitoring of fire sprinkling systems (if any); the Buildings proportionate share of common expenses owed to the Eagleview Corporate Center Association or its successor or any other similar entity which
owns and maintains the common areas of the Center (collectively, Association); and such other expenses as Landlord may deem necessary and proper in connection with the operation and maintenance of the Building, excluding any costs which
under GAAP are capital expenditures; provided, however, that Operating Expenses shall also include the annual amortization (over the anticipated useful life established in accordance with GAAP) of a capital improvement falling within any of the
following categories: (i) a labor saving device or improvement which is intended to reduce or eliminate any other component of Operating Expenses; (ii) an installation or improvement required by reason of any law, ordinance or regulation,
which requirement did not exist on the date of this Lease and is generally applicable to similar buildings; (iii) an installation or improvement which directly enhances safety of tenants in the Building or Center generally. Landlord shall have
the right to bill Tenant directly for any items of Operating Expenses which can be attributed directly to Tenants use only.



3



---

Notwithstanding any provision to the contrary, Operating Expenses shall not include:

(A) any payments (such as salaries or fees) to the Landlords executive personnel or in-house site managers except for the Management Fee;

(B) depreciation or interest, except to the extent permitted above in connection with capital improvements;

(C) mortgage or ground lease payments;

(D) taxes on the Landlords business (such as income, excess profits, franchise, capital stock, estate, inheritance) except to the extent the same are in lieu of Real Estate Taxes or increases in Real Estate Taxes;

(E) leasing commissions, brokers fees or legal fees incurred in connection with leases of space in the Building;

(F) legal fees that do not directly benefit Tenant or the Building (provided that legal fees incurred in connection with leases of space in the Building
or in enforcing tenant obligations shall not be deemed to benefit the Building);

(G) costs to correct original construction defects or
defective repairs or replacements hereinafter provided by or at the direction of Landlord;

(H) costs of repairs covered by valid
warranties;

(I) expenses paid directly by a tenant for any reason (such as excessive utility use, direct utility consumption or damage
for which such tenant is responsible);

(J) costs for improving any tenants space;

(K) any repair or other work necessitated by condemnation, fire or other insured casualty;

(L) any costs, fines and the like due to Landlords violation of any law, governmental rule or authority;

(M) refinancing costs;

(N) costs for any
conversion of the heating system to gas heat except to the extent such conversion is undertaken in an effort to reduce Operating Expenses and the cost thereof is treated in the same manner as a capital improvement;



4



---

(O) costs paid to Landlord or its affiliates other than the Management Fee which exceed those reasonably
charged in arms length transactions with third parties in the general area of the Building; and

(P) services, benefits or both provided
to some tenants but not to Tenant.

(b) Tenant shall pay Landlord the minimum annual rent (Minimum Annual Rent) during the
Initial Term in the amounts set forth below, which annual amount shall be paid in equal monthly installments as set forth below on the first day of each calendar month in advance. The first monthly installment of Minimum Annual Rent shall be due on
the Commencement Date. If the Commencement Date is not the first day of a calendar month, rent from the Commencement Date to the first day of the following month apportioned at the Minimum Annual Rent rate (based on a 365-day year) shall be paid.
All rent shall be payable, in advance, and without prior notice or demand, at the address of Landlord set forth in the heading of this Lease or at such other place, or to such other person, as Landlord may from time to time direct in written notice
to Tenant. During the Initial Term, Minimum Annual Rent for each lease year (being 12 months from the Commencement Date or anniversary thereof) shall be as follows:



|                        |  |                             |        |             |   |                     |  |   |           
|----------------------- |  | --------------------------- | ------ | ----------- | - | ------------------- |  | - | ----------
|Lease Year              |  | Rate PerRentableSquare Foot |        | Annual Rent |   | Monthly Installment
|1 (first 6 months)      |  | $                           | 9.5055 |             | $ | 743,938.45          |  | $ | 61,994.87 
|1 (second 6 months)     |  | $                           | 15.10  |             | $ | 1,181,786.40        |  | $ | 98,482.20 
|2                       |  | $                           | 15.65  |             | $ | 1,224,831.60        |  | $ | 102,069.30
|3                       |  | $                           | 16.20  |             | $ | 1,267,876.80        |  | $ | 105,656.40
|4                       |  | $                           | 16.75  |             | $ | 1,310,922.00        |  | $ | 109,243.50
|5                       |  | $                           | 17.30  |             | $ | 1,353,967.20        |  | $ | 112,830.60
|6                       |  | $                           | 17.85  |             | $ | 1,397,012.40        |  | $ | 116,417.70
|7                       |  | $                           | 18.30  |             | $ | 1,432,231.20        |  | $ | 119,352.60
|8 (first 6 months only) |  | $                           | 18.75  |             | $ | 1,467,450.00        |  | $ | 122,287.50

In addition to the foregoing, Tenant shall pay all amounts when and as required in the Work
Letter.

(c) In addition, Tenant shall pay to Landlord as Additional Rent in equal
monthly installments one twelfth (1/12) of Tenants Proportionate Share of annual Real Estate Taxes and Operating
Expenses, at the time of payment of each monthly installment of Minimum Annual Rent, based upon the most recent costs of Operating Expenses and Real Estate Taxes available. For the period from the Commencement Date until the issuance of a statement
pursuant to subparagraph 3(d) below, such monthly installment shall be equal to $38,479.80.



5



---

(d) Within ninety (90) days of the expiration of each calendar year Landlord shall furnish Tenant
with a written statement of the actual Operating Expenses and Real Estate Taxes incurred for such year itemizing the expenses claimed by Landlord in reasonable detail. Within ten (10) days of the rendition of such statement, Tenant shall pay
any amounts in excess of those collected pursuant to the payments on account of Real Estate Taxes and Operating Expenses pursuant to paragraph 3(c) hereof, and any overpayments shall be credited against the next installment(s) of rent due under this
Lease or, at Tenants option, refunded to Tenant. In the event the first and/or last years of the Term of this Lease shall not be full calendar years, then Tenants obligation for Operating Expenses and Real Estate Taxes attributable to
such years shall be pro rated. Tenant may, at its own cost and expense, after full payment of all sums due and owing, audit Landlords books and records not more than once each year within sixty (60) days after Landlords delivery of
its annual statement of Operating Expenses, which books and records shall be maintained in accordance with GAAP. Notwithstanding the foregoing, if any said review of Landlords books and records reveals that any item(s) were incorrectly
included in Operating Expenses, Tenant shall have the right to inspect Landlords books and records with respect to such items for each prior lease year and an adjustment, if any, shall be made in accordance herewith. If Tenants audit
determines that Landlords total charges for Operating Expenses or Real Estate Taxes for a given lease year exceed by more than 5% the total amount properly chargeable to Tenant under this Lease for such year, Landlord, in addition to
reimbursing Tenant such excess amount, shall pay Tenant an amount equal to the cost of the audit.

4. ADDITIONAL RENT.

Tenant shall pay to Landlord as Additional Rent (in addition to sums payable pursuant to paragraphs 3 (c) and 3(d)) the
following:

(a) Expenses Incurred by Landlord as a Result of Tenants Default. All sums which may become due by reason of
Tenants failure to comply with any of the terms, conditions and covenants of this Lease to be kept and observed by Tenant, and any and all damages, costs and expenses (including without limitation thereto reasonable attorneys fees) which
Landlord may suffer or incur by reason of any default of Tenant and any damage to the Building or the real estate of which the Building is a part caused by any negligence or willful misconduct of Tenant or violation of Tenants covenants in
Section 5(a) below (subject, however, to the provisions of Section 17(e) below), together with interest to the date of payment (whether before or after entry of judgment and issuance of execution thereon) at a rate equal to five
percent (5%) above the prime interest rate (or similar rate if the prime interest rate is no longer published) as published in The Wall Street Journal, in effect on the date during the period said payment is due (Default Rate),
which shall continue to accrue interest at the Default Rate after entry of judgment and issuance of execution thereon until paid in full.

(b) Use and Occupancy Taxes. All use and occupancy taxes imposed by any governmental body allocable to the Leased Space.

(c) Utilities. Tenant shall pay all charges for gas and electric, as billed directly by the providers of the same to Tenant.



6



---

For purposes of this Lease, the term Rent or rent shall be deemed to refer to
Minimum Annual Rent and Additional Rent.

5. NEGATIVE COVENANTS OF TENANT: HAZARDOUS SUBSTANCES.

(a) Tenant will not:

(i) damage the Leased
Space or any other part of the Building;

(ii) bring into or permit to be kept in the Leased Space any dangerous, explosive or obnoxious
substances except as may be used in Tenants Business which use Tenant shall undertake in compliance with all applicable laws regulating same;

(iii) conduct itself or permit its agents, servants, employees or invitees to conduct themselves in a manner that in Landlords judgment reasonably exercised is improper or unsafe except that the operation of, or
activities related to, Tenants Business in a manner consistent with the use of the Leased Space permitted by this Lease shall not be deemed to violate this provision, provided same are undertaken in compliance with all applicable laws;

(iv) manufacture any commodity or prepare or dispense any food or beverages in the Leased Space, except for consumption in the Leased
Space by Tenant, its employees or invitees;

(v) remove, attempt to remove or manifest any intention to remove Tenants goods or
property from the Leased Space other than in the ordinary course of business;

(vi) do or suffer to be done, any act, matter or thing
objectionable to Landlords fire insurance companies or Board of Underwriters whereby the fire insurance or any other insurance now in force or hereafter to be placed by Landlord on the Leased Space or the Building or Center shall become void
or suspended or whereby the manner in which Tenant conducts Tenants Business causes the Leased Space, Building or Center to be rated as a more hazardous risk than at the Commencement Date. Tenant agrees to pay to Landlord as Additional Rent,
any and all increases in premiums for insurance carried by Landlord on the Leased Space, or on the Building, caused in any way by the occupancy of Tenant.

(b) Tenants Responsibility Regarding Hazardous Substances.

(i) The following definitions
shall apply herein:

(A) Hazardous Substances. The term Hazardous Substances, as used in this Lease, shall include,
without limitation, flammables, explosives, radioactive materials, asbestos, polychlorinated biphenyls (PCBs), chemicals known to cause cancer or reproductive toxicity, pollutants, contaminants, hazardous wastes, toxic substances or related
materials, petroleum and petroleum products, and substances declared to be hazardous or toxic



7



---

under any law or regulation now or hereafter enacted or promulgated by any governmental authority.

(B) Tenant Responsible Parties. The term Tenant Responsible Parties as used in this Lease shall mean Tenant, its employees, agents,
contractors and/or invitees.

(ii) Tenants Restrictions. Tenant shall not cause or permit to occur:

(A) Any violation of any federal, state, or local law, ordinance, or regulation now or hereafter enacted, related to environmental conditions on, under,
or about the Leased Space or Center, arising from the use or occupancy of the Leased Space by any Tenant Responsible Party, including, but not limited to, soil and ground water conditions; or

(B) The use, generation, release, manufacture, refining, production, processing, storage, or disposal of any Hazardous Substance on, under, or about the
Leased Space or Center, except as may be used in Tenants Business in a manner consistent with the use of the Leased Space permitted by this Lease, which use, generation, release, manufacture, refining, production, processing, storage, or
disposal Tenant shall undertake in compliance with all applicable Laws (defined below).

(iii) Environmental Clean-Up.

(A) Tenant shall, at Tenants own expense, comply with all laws regulating the use, generation, storage, transportation, or disposal of Hazardous
Substances (Laws) by Tenant Responsible Parties.

(B) Tenant shall, at Tenants own expense, make all submissions to,
provide all information required by, and comply with all requirements of all governmental authorities (Authorities) under the Laws as are applicable to use of Hazardous Substances by Tenant Responsible Parties.

(C) Should any Authority or any third party demand that a clean-up plan be prepared and that a clean-up be undertaken because of any deposit, spill,
discharge, or other release of Hazardous Substances that occurs during the Term of this Lease at or from the Leased Space and which arises at any time from the use of Hazardous Substances by Tenant Responsible Parties, then Tenant shall, at
Tenants own expense, prepare and submit the required plans and all related bonds and other financial assurances, and Tenant shall carry out all such clean-up plans.

(D) Tenant shall promptly provide all information regarding the use, generation, storage, transportation, or disposal of Hazardous Substances by Tenant
Responsible Parties that is requested by Landlord. If Tenant fails to fulfill any duty imposed under this subparagraph (iii) within a reasonable time, Landlord may do so; and in such case, Tenant shall cooperate with Landlord in order to
prepare all documents Landlord deems



8



---

necessary or appropriate to determine the applicability of the Laws to the Leased Space and use of Hazardous Substances by Tenant Responsible Parties, and
for compliance therewith, and Tenant shall execute all documents promptly upon Landlords request. No such action by Landlord and no attempt made by Landlord to mitigate damages under any Law shall constitute a waiver of any of Tenants
obligations under this Subparagraph (iii).

(E) Tenants obligations and liabilities under this Subparagraph (iii) shall survive
the expiration of this Lease.

(iv) Tenants Indemnity.

(A) Tenant shall indemnify, defend, and hold harmless Landlord, the manager of the Center, and their respective officers, directors, beneficiaries,
shareholders, partners, agents and employees, from all fines, suits, procedures, claims, and actions of every kind, and all costs associated therewith (including reasonable attorneys and consultants fees) arising out of or in any way
connected with any deposit, spill, discharge, or other release of Hazardous Substances that occurs during the Term of this Lease at or from the Leased Space and which arises at any time from use of Hazardous Substances by Tenant Responsible Parties,
or from failure by Tenant Responsible Parties to provide all information, make all submissions, and take all steps required by all Authorities under the Laws with respect thereto.

(B) Tenants obligations and liabilities under this Subparagraph (iv) shall survive the expiration of this Lease.

6. LATE PAYMENT.

If any
payment required by Tenant under any of the terms hereof shall not be paid within five (5) days after written notice from Landlord that such payment is overdue, Tenant shall, upon demand, pay a late charge to Landlord equal to the greater of
(a) Fifty ($50.00) Dollars or (b) $.05 for each dollar so due, and such late charge shall be deemed Additional Rent for purposes of this Lease; provided, however, that such late charge shall be due immediately without notice upon any
failure to pay when due during any twelve (12) month period in which Landlord shall have given such written notice on two (2) prior occasions.

7. CONSTRUCTION OF LEASED SPACE.

(a) Landlord shall, without cost to Tenant except as
provided in the Work Letter, complete Landlords Work as defined in the Work Letter attached hereto. Landlord shall furnish the drawings and specifications to complete the Tenant Improvements and, in addition, shall complete the
construction and other items of work in the Leased Space which are not within the scope of Landlords Work. If, at Tenants request, Landlord performs any items of work or furnishes any materials which Landlord is not required to perform
or furnish hereunder, Tenant shall pay Landlord for such additional work and materials, at such reasonable rates as Landlord may charge. If the TI Plans as defined in the Work Letter, or a description thereof



9



---

which is reasonable to identify same, have not been attached hereto upon execution hereof, the TI Plans when completed in accordance with the Work Letter
shall be initialed for identification by Landlord and Tenant and become part of this Lease when so initialed.

(b) Within thirty
(30) days after the Commencement Date, Tenant shall give Landlord a written list (Final Punch List) of all contended defects, if any, in Landlords construction work and of all contended variances in Landlords Work from
the requirements hereof. Except for defects or deficiencies which are not then discoverable by Tenant, or which are covered by third-party warranties or Landlords warranty set forth in the Work Letter (collectively, Defects), any
and all variances not set forth in the Final Punch List shall be deemed to be waived by Tenant. Landlord shall correct all items on the Final Punch List that constitute valid defects or variances within sixty (60) days after Landlords
receipt of the Final Punch List, unless the nature of the defect or variance is such that a longer period of time is required to repair or correct the same, in which case Landlord shall exercise due diligence in correcting such defect or variance at
the earliest possible date and with a minimum of interference with the operation of Tenant. If Landlord does not complete such work within the time specified above, Tenant shall have the right to complete such work at Landlords expense. Any
disagreement that may arise between Landlord and Tenant with respect to whether an item on the Final Punch List constitutes a valid defect or variance shall be conclusively resolved in the manner contemplated by the Work Letter.

(c) By occupying the Leased Space as Tenant, Tenant shall be deemed to have accepted the Leased Space and to have acknowledged that the Leased Space is
in the condition required by this Lease, except as to any defects or variances set forth on the Final Punch List or Defects.

8.
TENANTS ALTERATIONS.

(a) Except as hereafter provided, Tenant shall make no alterations, additions or improvements
(Tenant Alterations) to the Leased Space without the consent of Landlord, which consent shall not be unreasonably withheld, delayed or conditioned. Tenant Alterations contemplated by Tenant, the location, plans and specifications for
which shall be subject to Landlords consent, not to be unreasonably withheld, delayed or conditioned, may include a generator and diesel tank on the Land and connections to the Building, a data line to the Building, and additional HVAC for a
data room. The data line may require Tenant to excavate the lawn, parking area, driveway and/or roadway, which will be done in accordance with Landlords reasonable requirements to minimize disturbance to other parties, and which shall require
Tenant at its expense to restore any areas disturbed promptly following installation of the data line. At the time of Landlords consent, Landlord shall designate whether Tenant shall be required to remove the proposed Tenant Alteration upon
termination of this Lease, and the absence of such designation in Landlords written consent shall be deemed Landlords agreement that Tenant shall not be obligated to remove Tenant Alterations upon the termination of this Lease. Landlord
also may impose such reasonable conditions as part of its consent as Landlord deems appropriate, taking into consideration the nature of the proposed Tenant Alteration, including, without limitation, requiring Tenant to furnish Landlord with
security for the payment



10



---

of all costs to be incurred in connection with such work, insurance, and copies of the plans, specification and permits necessary for such work. Nothing
herein, however, shall be construed to obligate Tenant to construct any Tenant Alteration for which Landlord has given its consent.

(b)
Landlords consent shall not be required for Tenant Alterations which (i) do not adversely impact the structural integrity of the Building or the systems serving the Building or their operation, (ii) are not visible from the Building
exterior and (iii) qualify under the following:

(i) The Tenant Alterations cost is $10,000 or less with respect to any Tenant
Alteration project (or $20,000 or less in the aggregate with respect to Tenant Alteration projects undertaken over any twelve (12) consecutive month period);

Tenant Alterations described in this subsection (b) for which Landlords consent is not required hereinafter are called Permitted Tenant Alterations. Notwithstanding the foregoing,
painting or carpeting of the interior of the Leased Space and like cosmetic improvements shall not be deemed Tenant Alterations regardless of the cost thereof. Tenant shall not be obligated to remove Permitted Tenant Alterations upon the termination
of this Lease unless an Event of Default has occurred which is then continuing and Landlord so requires such removal.

(c) All Tenant
Alterations shall be done at Tenants expense by contractors approved by Landlord, which consent shall not be unreasonably withheld, delayed or conditioned and shall be deemed given unless Landlord notifies Tenant of its objections within ten
(10) business days after delivery of Tenants request for consent. With respect to Tenant Alterations other than the Permitted Tenant Alterations, no work shall be performed until the plans therefore have been approved by Landlord, which
approval shall not be unreasonably withheld, delayed or conditioned and shall be deemed approved unless Landlord notifies Tenant of objections to the proposed plans within ten (10) business days after delivery to Landlord of a complete set of
the plans therefor. In connection with the review of plans submitted by Tenant, Landlord shall be reimbursed by Tenant for Landlords cost in reviewing such plans at the rate of $85 per hour; subject to reasonable increase to reflect the then
current hourly charge imposed for such review by Landlord for its tenants in the Center generally, and prior to undertaking any such review, Landlord shall provide a statement of the maximum review hours to be dedicated to such review. With respect
to Permitted Tenant Alterations, Tenant shall provide Landlord with a copy of Tenants application for a building permit therefor, if applicable (together with all attachments thereto), and no review fee shall be charged to Tenant by Landlord
in connection therewith nor shall Landlords approval of such application be required. Tenant shall provide copies of as-built plans and specifications for all Tenant Alterations to Landlord within a reasonable time of completion of the Tenant
Alteration. All Tenant Alterations shall be done in a first class, workmanlike manner and shall comply with all insurance requirements then made available to Tenant and all applicable laws, ordinances, rules and regulations of governmental
authorities having jurisdiction thereover, and, where applicable, with all reasonable requirements of Landlord imposed as a condition of such consent.



11



---

(d) If, as a condition of Landlords consent, removal of a Tenant Alteration is required at
termination of this Lease, Tenant shall promptly remove such Tenant Alterations and repair any damage occasioned by such removal. In default thereof, Landlord may effect said removal and repairs at Tenants expense. With respect to any Tenant
Alterations which Tenant is not obligated to remove hereunder (including without limitation Permitted Tenant Alterations), such Tenant Alterations, if not removed by Tenant upon the termination of this Lease, shall be deemed abandoned by Tenant, and
deemed a part of Landlords property, notwithstanding any provision of Section 16 to the contrary.

9.
MECHANICS LIENS.

If Tenant performs or orders (other than through Landlord or Landlords contractors) any
construction or other work on or about the Leased Space for which a lien could be filed against the Leased Space or the Building, Tenant shall obtain from the contractor who performs such work a release of any liens which could be filed under the
Mechanics Lien Law of the Commonwealth of Pennsylvania for such work which has been completed and paid for by Tenant, at the time of payment, and obtain similar releases from all subcontractors, sub-subcontractors and material suppliers.
Notwithstanding the foregoing, if any mechanics or other lien shall be filed against the Leased Space or the Building purporting to be for labor or material furnished or to be furnished at the request of the Tenant other than through Landlord
or Landlords contractors, then Tenant shall at its expense cause such lien to be discharged of record by payment, bond or otherwise, within fifteen (15) days after Tenant receives notice of the filing thereof. If Tenant shall fail to
cause such lien to be discharged by payment, bond or otherwise within such period, Landlord may cause such lien to be discharged by payment, bond or otherwise, without investigation as to the validity thereof or as to any offsets or defenses
thereto, and Tenant shall, upon demand, reimburse Landlord for all amounts paid and costs incurred, including attorneys fees, in having such lien discharged of record. If, however, Tenant notifies Landlord during such fifteen (15) day
period that it disputes the validity of such lien and provides security reasonably acceptable to Landlord in an amount which is sufficient to discharge such lien in full, Landlord shall refrain from satisfying such lien for a period not to exceed
one hundred twenty (120) days.

10. CONDITION OF LEASED SPACE.

Tenant acknowledges and agrees that, except as expressly set forth in this Lease, there have been no representations or warranties made by or on behalf of
Landlord with respect to the Leased Space or the Building or with respect to the suitability of either for the conduct of Tenants Business.

11. BUILDING SERVICES.

Landlord shall operate and maintain the Building and the Center in a manner comparable to
other office buildings in Exton, PA. Landlord shall provide all heat, light, electricity, air conditioning and restroom facilities, elevator service and janitorial services (as shown on Exhibit D attached hereto), and as
otherwise required by Tenant. It is understood



12



---

that this Lease is intended to be net of taxes, repairs, insurance and operating expenses. Tenant shall have access to the Leased Space on a 24 hour per day,
7 day per week basis and Landlord shall provide heat, light, electricity, air conditioning and restroom facilities during those hours, provided, however, Landlord shall not be obligated to provide maintenance services, including without limitation,
repairs, and snow removal other than a reasonable time prior to and during normal business hours (8 AM to 6 PM, Monday through Friday), sufficient to allow Tenants ordinary use of the Leased Space, during normal business hours. Where such
services are required because of an emergency other than during normal business hours, Landlord shall use reasonable efforts to provide them other than during normal business hours as the emergency may require. Landlord shall provide normal
janitorial services after normal business hours.

Unless otherwise agreed with Tenant in writing, Landlord agrees that all maintenance to
the common areas external to the Building which the Association offers to perform or is obligated to perform for the benefit of lots in the Center shall be performed by the Association. Landlord shall use diligent efforts to enforce any such
obligation of the Association. Except during such period of time as Landlord or its affiliates control the Association, Landlord shall not be liable in damages or otherwise for temporary delay or failure in furnishing any services or facilities to
be provided by Landlord or the Association under this Lease or any other agreement between Tenant and Landlord (or its agents) or implied by law

Landlord shall maintain, repair and replace, when needed the foundation, roof and exterior walls, exterior of and the frames surrounding all windows, doors and plate glass, and maintain and make when required repairs to the Building and
areas of the Center. In lieu of repairing items whose useful life has been exhausted or which have been damaged beyond repair, which damage was not caused by abuse by Tenant, its agent and invitees, in Landlords judgment exercised in good
faith, Landlord shall replace such items. Tenant shall give Landlord written notice of the need for the above repairs. Landlord shall cause such repair or replacement to be performed in a good and workmanlike manner and within a reasonable time
after receipt of written notice from Tenant stating the need therefor. Subject to the provisions of Section 17(e), the cost of any repairs or replacements, even if otherwise not to be part of Operating Expenses, caused by the negligence,
misuse or misconduct of Tenant or its agents or invitees, shall be paid by Tenant.

12. ASSIGNMENT AND SUBLETTING.

(a) Tenant shall not, without the prior written consent of Landlord, assign or mortgage this Lease or any interest therein or sublet the
Leased Space or any part thereof. For the purposes of this paragraph, the sale or assignment of a controlling interest in the Tenant corporation or a majority interest in the Tenant partnership as the case may be, shall be deemed an assignment, but
the assignment to a parent, wholly-owned subsidiary of the Tenant or successor corporation shall be permitted, provided that such assignee assumes the obligations of Tenant and that such assignment shall not relieve Tenant of its obligations
hereunder. For purposes herein, (A) a successor corporation is one into which Tenant is merged or consolidated,



13



---

or which acquired those of Tenants assets or business located in the Leased Space as of the date of the assignment, and (B) a controlling interest
shall mean the ownership of fifty percent or more of the beneficial interest in the person or entity in question, unless the corporation is publicly traded in which case such transfers of stock (whether or not a controlling interest) shall not be
deemed to be an assignment. As to any other assignment or subleasing to be effective after the thirty-first (31st) full month of the Term,
Landlord agrees that it shall not unreasonably withhold its consent, provided the business of Tenants assignee or subtenant is no more hazardous than that of Tenant, it being understood that Landlord shall not be obligated to consent at the
time there is other comparable space available for lease at the Center which is owned by Landlord or an affiliate of Landlord, and that it shall not be unreasonable for Landlord to require, as a condition of such consent:

(b) That 50% of any money or other economic consideration received by Tenant as a result of such subletting or assignment and which is not properly
allocable to any lease of Tenants personal property in the Leased Space or sale of Tenants assets from the business operated at the Leased Space or sale of Tenants stock or other arms-length transaction, which exceeds, in the
aggregate, the total sums which Tenant is obligated to pay Landlord under this Lease (pro rated to reflect obligations allocable to that portion of the Leased Space subject to the sublease or assignment) shall be payable to Landlord as Additional
Rent under this Lease without affecting or reducing any other obligation of Tenant hereunder; and

(c) Unless otherwise agreed in
Landlords consent, no subletting or assignment shall release Tenant of Tenants obligation or alter the primary liability of Tenant to pay the rental and to perform all other obligations to be performed by Tenant hereunder. The acceptance
of rental by Landlord from any other person shall not be deemed to be a waiver by Landlord of any provision hereof. Consent to one assignment or subletting shall not be deemed consent to any subsequent assignment or subletting. In the event of
default by any assignee of Tenant or any successor of Tenant in the performance of any of the terms hereof, Landlord may proceed directly against Tenant without the necessity of exhausting remedies against such assignee or successor. Landlord may
consent to subsequent assignment or subletting of this Lease or amendments or modifications to this Lease with assignees of Tenant, without notifying Tenant, or any successor of Tenant, and without obtaining its or their consent thereto and such
action shall not relieve Tenant of liability under this Lease.

13. ACCESS TO LEASED SPACE.

Landlord, its employees and agents, shall have the right to enter the Leased Space at all reasonable times for the purpose of examining or inspecting the
same, showing the same to prospective purchasers or tenants of the Building, or mortgagees, and making such alterations, repairs, improvements or additions to the Leased Space or to the Building as Landlord may deem necessary or desirable provided
such alterations, repairs, improvements or additions do not adversely affect Tenants Business or use of the Leased Space or, except with Tenants consent, alter the Tenant Improvements performed in accordance with the Work Letter or
approved Tenants Alterations. Except in case of emergency in Landlords reasonable judgment, any such entry shall be after reasonable notice to Tenant and in compliance with Tenants practices from



14



---

time to time established with respect to areas where confidential information is located. If a representative of Tenant shall not be present to open and
permit entry into the Leased Space at any time when such entry by Landlord is necessary in an emergency, Landlord may enter by means of a master key (or forcibly) without liability to Tenant and without such entry constituting an eviction of Tenant
or termination of this Lease. All keys must be returned to Landlord at the expiration or termination of the Lease.

14.
REPAIRS.

(a) Landlord shall repair, maintain and as necessary, replace, the roof, load bearing walls (other than paint and
wall coverings), floors (other than carpeting, tile and similar floor coverings), foundations and other structural elements of the Building, and all plumbing and electrical fixtures and equipment and HVAC system components serving the Building;
provided, however, that Landlord shall not be obligated for any of such repairs until the expiration of a reasonable period of time after written notice that such repair is needed. The cost of same shall be included in the Operating Expenses to the
extent provided in Section 3(a)(iii) unless the necessity for any of the foregoing arises (a) from the gross negligence or willful and wanton misconduct of Landlord or its employees or, subject to Section 3(a)(iii)(i)
hereof, by any other tenant of the Center or such tenants agents, employees, licensees, or invitees, in which case such cost shall not be included as part of the Operating Expenses but shall be paid by Landlord (without prejudice to
Landlords right to recover same from the responsible party), or (b) negligence or willful and wanton misconduct of Tenant, its agents, employees, licensees or invitees, in which case such cost shall be paid by Tenant. Any such
maintenance, replacements or repairs and any labor performed or materials furnished by or upon the direction of Landlord shall be performed in a good and workmanlike manner, using only materials of at least the same quality and integrity as that
being repaired or replaced, and performed and furnished in compliance with all applicable laws, regulations, ordinances and requirements of all duly constituted authorities or governmental bodies having jurisdiction over the Building, and the
requirements of any board of underwriters having jurisdiction thereof.

(b) Except as the Landlord is obligated for repairs as provided
above or in Section 11, Tenant shall make, at its sole cost and expense, all repairs necessary to maintain the Leased Space and the fixtures therein in neat and orderly condition. If the Tenant refuses or neglects to make such repairs or
fails to diligently prosecute the same to completion after written notice from Landlord of the need therefore and a reasonable time for cure, Landlord may make such repairs at the expense of Tenant and such expense shall be collectible as Additional
Rent. Any such repairs and any labor performed or materials furnished in, on or about the Leased Space shall be performed and furnished by Tenant in compliance with all applicable laws, regulations, ordinances and requirements of duly constituted
authorities or central bodies having jurisdiction over the Building, the requirements of any board of underwriters having jurisdiction thereof, as well as any reasonable regulations imposed by Landlord pertaining thereto. Without limitation of the
foregoing, Landlord shall have the right to approve any and all contractors and suppliers to furnish materials and labor for such repairs, which consent shall not be unreasonably withheld, delayed or conditioned.



15



---

(c) If required solely as a result of Tenants particular activities at the Leased Space (as
opposed to general occupancy thereof by any tenant), Tenant also shall comply with, and make any repairs and installations required by any applicable law.

(d) Provided that Landlord shall exercise reasonable efforts to effectuate its repairs in a manner which will keep at a minimum Landlords interference with Tenants use and occupancy of the Leased Space,
Landlord shall not be liable by reason of any injury to or interference with Tenants Business arising from the making of any repairs, alterations, additions or improvements in or to the Leased Space, or the Building or Center or to any
appurtenances or equipment therein.

15. TERMINATION AND EXTENSION.

(a) It is hereby mutually agreed that this Lease shall terminate at the end of the term if a renewal right has not been exercised or, if exercised, upon
the end of any renewal term, without notice by either party.

(b) If Tenant shall hold over after the expiration of the Term hereof (as
may be extended pursuant to Section 45 below), and Landlord shall not give consent to such hold over by Tenant, such tenancy may be terminated as permitted by applicable state law, and until Tenant has vacated the Leased Space, it agrees
to pay to Landlord rent at a monthly rental double the rate payable by Tenant at the expiration of the Term of this Lease.

16.
SURRENDER OF LEASED SPACE.

At the end of the Term of this Lease, Tenant shall surrender the Leased Space to Landlord, in
broom clean condition and in good order and repair except for ordinary wear and tear and damage for which Tenant is not obligated to make repairs under this Lease. Subject to Sections 8 and 9 hereof and if an Event of Default has not occurred
which is then continuing, Tenant shall have the right at the end of the Term hereof to remove any Tenant Alterations and any equipment, furniture, trade fixtures or other personal property placed in the Leased Space by Tenant, provided that Tenant
promptly repairs any damage to the Leased Space caused by such removal. Tenant shall repair all damage to the Leased Space caused by such removal and restore the Leased Space to the condition in which they were prior to the installation of the items
so removed, reasonable wear and tear and damage by casualty not caused by Tenant excepted. Tenant shall surrender the Leased Space to Landlord at the end of the term hereof, without notice of any kind, and Tenant waives all right to any such notice
as may be provided under any laws now or hereafter in effect in Pennsylvania. If Tenant shall fail to remove any Tenant Alterations which it was required to remove pursuant to Section 8 of this Lease or any of its equipment, furniture,
trade fixtures or other personal property, Landlord may remove and store the same at the expense of Tenant or sell the same on behalf of Tenant at public or private sale in such manner as is commercially reasonable, with any proceeds thereof to be
first applied to the costs and expenses, including attorneys fees, of the storage and sale and the payment of any amounts owed hereunder by Tenant.



16



---

17. INDEMNIFICATION AND INSURANCE.

(a) Tenant covenants and agrees that it shall, without notice or demand and at its own cost and expense, indemnify and save harmless Landlord against and
from, and Landlord shall not be liable to Tenant for, any and all claims by or on behalf of any person arising in any manner whatsoever from, out of, or in connection with any accident, death, injury, or damage, loss or theft of property in or about
the Leased Space (whether involving property belonging to Tenant or any other person) resulting from the negligence or willful misconduct of Tenant, its agents, employees, licensees or invitees, and from and against all costs, reasonable attorney
fees, expenses and liabilities incurred in or as a result of any such claim or action or proceeding brought against Landlord by reason of any such claim. Tenant, upon notice from Landlord, covenants to resist or defend such action or proceeding by
legal counsel reasonably satisfactory to Landlord. The indemnification obligations under this paragraph shall not be limited in any way by any limitation on the amount or type of damages, compensation or benefits payable by or for the Tenant, or any
other person, under Workers or Workmans Compensation statutes, disability benefits statutes or other employee benefit laws.

(b)
Tenant shall keep in force commercial general liability insurance with respect to the Leased Space, including contractual insurance with respect to the covenants and agreements above, with companies and in form reasonably acceptable to Landlord to
afford protection of not less than Two Million ($2,000,000.00) Dollars with respect to personal injury or death and property damage, and naming Landlord as an additional insured and providing not less than thirty (30) days notice of
cancellation. Copies of such policies or a certificate of insurance evidencing same shall be delivered to Landlord.

(c) Landlord
covenants and agrees that it shall, without notice or demand and at its own cost and expense, indemnify and save harmless Tenant against and from, and Tenant shall not be liable to Landlord for, any and all claims by or on behalf of any person
arising in any manner whatsoever from, out of, or in connection with any accident, death, injury, or damage, loss or theft of property in or about the Leased Space (whether involving property belonging to Landlord or any other person) resulting from
the gross negligence or wanton and willful misconduct of Landlord, its agents or employees, and from and against all costs, reasonable attorney fees, expenses and liabilities incurred in or as a result of any such claim or action or proceeding
brought against Tenant by reason of any such claim. Landlord, upon notice from Tenant covenants to resist or defend such action or proceeding by legal counsel reasonably satisfactory to Tenant. The indemnification obligations under this paragraph
shall not be limited in any way by any limitation on the amount or type of damages, compensation or benefits payable by or for the Landlord, or any other person, under Workers or Workmans Compensation statutes, disability benefits statutes or
other employee benefit laws.

(d) Landlord shall keep in force commercial general liability insurance with respect to the Building,
including contractual insurance with respect to the covenants and agreements above, with companies and in form reasonably acceptable to Tenant to afford protection of not less than Two Million ($2,000,000.00) Dollars with respect to personal injury



17



---

or death and property damage, and naming Tenant as an additional insured and providing not less than thirty (30) days notice of cancellation.
Copies of such policies or a certificate of insurance evidencing same shall be delivered to Tenant.

(e) All property insurance policies
also shall contain a clause or endorsement denying the insurer any rights of subrogation against Landlord, in the case of Tenants insurer, and Tenant, in the case of Landlords insurer. As to any loss or damage covered by insurance
containing a waiver of subrogation clause or similar endorsement, or to the property of a party arising from a peril normally covered by the ISO Causes of Loss-Special Form (CP 10 30) insurance policy, or its equivalent, with coverage extended for
the perils of flood and earthquake, each party hereby releases the other, from any and all liability for such loss or damage to such partys property, even if such loss or damage shall be brought about by the fault or negligence of such other
party, or the agents, employees, invitees or licensees of such other party.

18. FIRE OR OTHER CASUALTY.

(a) At all times during the Term of this Lease, Landlord shall maintain in full force and effect a property insurance policy on the Building against loss
from perils covered by the ISO Causes of Loss-Special Form (CP 10 30), or its equivalent, with coverage extended for the perils of flood and earthquake, in an amount equal to full insurable replacement cost. Such insurance shall contain an agreed
valuation provision in lieu of any co-insurance clause, an ordinance and law endorsement, debris removal coverage, and a waiver of subrogation endorsement in favor of Landlord. Such policy may include a commercially reasonable deductible. The
premium for such insurance shall be included as an Operating Expense. Such coverage shall be issued by any reputable insurance company licensed in Pennsylvania, with at least a Bests rating of A or better. Landlord agrees to
deliver a certificate evidencing such insurance coverage upon Tenants request from time to time.

(b) If the Leased Space or the
Building is partially damaged by fire or other casualty such that Tenant is able to conduct its business therein at a reduced but economically feasible level on a temporary basis, and insurance proceeds are available to Landlord, the damages shall
be repaired by and at the expense of Landlord and the rent, until such repairs shall be made, shall be apportioned from the date of such fire or other casualty according to the part of the Leased Space which is usable by Tenant. Landlord agrees to
repair such damage within a reasonable period of time after receipt from Tenant of written notice of such damage, except that Tenant agrees to repair and replace its own furniture, furnishings and equipment which were not provided as part of the
Tenant Improvements. If Landlord is unable to complete reconstruction of the damaged premises within two hundred ten (210) days from the date of the casualty, Tenant shall have the right to terminate this Lease.

(c) If the Leased Space or Building is totally damaged or is rendered wholly untenantable by fire or other casualty, each party shall have the right to
terminate the Lease by written notice to the other on or before thirty (30) days after such casualty occurred. If, however, Landlord consents in writing within thirty (30) days following such casualty to reconstruct the damaged premises to
the condition which existed prior to such casualty and a reputable



18



---

contractor acceptable to Landlord and Tenant determines that such reconstruction can be substantially completed within two hundred ten (210) days from
the date of such casualty, neither party shall have the right to terminate this Lease and Landlord shall undertake reconstruction of the damaged premises. If, however, Landlord is unable to complete reconstruction of the damaged premises within two
hundred ten (210) days from the date of the casualty, Tenant shall have the right to terminate this Lease.

(d) Whenever Landlord
shall be obligated hereunder to reconstruct damaged premises, Landlord agrees to undertake such reconstruction with reasonable diligence and, if Tenant shall remain in possession of any portion of the Leased Space, in such manner to as to minimize
interference or disruption of Tenants use of the Leased Space. Reconstruction shall be performed in a good and workmanlike manner, in accordance with standard construction practices and safety procedures, using only materials of at least equal
quality and integrity as the materials damaged by the casualty, undertaken in such manner so as to restore the damaged premises to substantially the condition which existed prior to such casualty, and performed and furnished in compliance with all
applicable laws, regulations, ordinances and requirements of all duly constituted authorities or governmental bodies having jurisdiction over the Building, and the requirements of any board of underwriters having jurisdiction thereof. For purposes
of implementing the foregoing, the parties agree to substantially adhere to the practices established by the Work Letter attached hereto.

(e) Upon the termination of this Lease under the conditions hereinbefore provided, Tenants liability for rent shall cease as of the day of the casualty. Tenant shall promptly vacate and surrender the Leased Space to Landlord in its
as is condition, whereupon neither party shall have any further rights or obligations hereunder except that Landlord shall reimburse to Tenant (i) any portion of the Security Deposit not otherwise applied by Landlord in accordance
with this Lease, and (ii) prepaid Rent paid by Tenant. Such reimbursement shall be made in full to Tenant not later than thirty (30) days following termination of this Lease, and if not so paid, such unpaid amounts shall accrue interest at
the Default Rate specified in this Lease from the date of termination until paid in full. The limitations set forth in Section 28 hereof shall not apply to Landlords liability for payment of the foregoing amounts.

19. CONDEMNATION.

If the
Leased Space or the Building or any material part of either shall be condemned or otherwise subject to an eminent domain proceeding, then and in that event, upon the transfer of title to the authority exercising such power, this Lease shall
terminate, and all rent paid in advance shall be apportioned as of the date of such termination. Notwithstanding the foregoing, if only a part of the Leased Space shall be so taken and the part not so taken shall be sufficient in Tenants
reasonable judgment for the economic and feasible operation of Tenants business, Tenant, at its election, may retain the part not so taken and there shall be a proportional reduction in the rent. All compensation awarded or paid upon such a
total or partial taking of the Leased Space shall belong to and be the property of the Landlord. The foregoing shall not, however, be construed to preclude the Tenant from prosecuting any claim directly against the condemning authority in such
condemnation proceedings for loss of business, or depreciation to, damage to,



19



---

or cost of removal of, or for the value of stock, trade fixtures, furniture, and other personal property belonging to the Tenant, provided, however, that no
such award or claim shall diminish or otherwise adversely affect the Landlords award (subject to Tenants interest therein as aforesaid).

20. ESTOPPEL CERTIFICATES.

At any time, and from time to time, upon the written request of
Landlord or any Mortgagee (as defined in Section 29 hereof), Tenant, within ten (10) business days of the date of such written request, agrees to execute and deliver to Landlord and/or such Mortgagee, a written
statement: (a) ratifying this Lease; (b) confirming the commencement and expiration dates of the Term of this Lease; (c) certifying that Tenant is in occupancy of the Leased Space, and that the Lease is in full force and effect and
has not been modified, assigned, supplemented or amended except by such writings as shall be stated; (d) certifying that all conditions and agreements under this Lease to be satisfied or performed by Landlord have been satisfied and performed
except as shall be stated; (e) certifying that Landlord is not in default under the Lease and there are no defenses or offsets against the enforcement of this Lease by Landlord, or stating the defaults and/or defenses claimed by Tenant;
(f) reciting the amount of advance rent, if any, paid by Tenant and the date to which such rent has been paid; (g) reciting the amount of security deposited with Landlord, if any; and (h) any other information which Landlord or the
Mortgagee reasonably may require. The failure of Tenant to execute, acknowledge and deliver to Landlord and/or any Mortgagee a statement in accordance with the provisions herein within the period set forth herein shall constitute an acknowledgment
by Tenant which may be relied upon by any person holding or intending to acquire any interest whatsoever in the Leased Space or the Building that this Lease has not been assigned, amended, changed or modified, is in full force and effect and that
the Minimum Annual Rent, and Additional Rent have been duly and fully paid not beyond the respective due dates immediately preceding the date of the request for such statement and shall constitute as to any persons entitled to rely on such
statements (other than Landlord) a waiver of any defaults by Landlord or defenses or offsets against the enforcement of this Lease by Landlord which may exist prior to the date of the written request.

21. DEFAULT.

The occurrence
of any of the following shall constitute an Event of Default of this Lease by Tenant:

(a) A failure by Tenant to pay, when
due, any installment of rent hereunder or any such other sum herein required to be paid by Tenant where such failure continues for ten (10) days after written notice thereof from Landlord; provided however said written notice shall not be
required to be given by Landlord more than twice in any twelve (12) month period.

(b) A failure by Tenant to observe and perform any
other terms or conditions of this Lease to be observed or performed by Tenant, where such failure continues for thirty (30) days after written notice thereof from Landlord to Tenant; provided that, if such default is of a nature that cannot be
reasonably cured within such thirty (30) day period, no default shall exist so



20



---

long as Tenant has commenced cure within such thirty (30) day period and diligently pursues same to completion within ninety (90) days.

(c) The making by Tenant of any assignment for the benefit of creditors, an adjudication that Tenant is bankrupt, insolvent, or unable to pay its
debts; the filing by or against Tenant of a petition in bankruptcy or of a petition for reorganization or arrangement under any law relating to bankruptcy (unless, in the case of a petition filed against Tenant, the same is dismissed within sixty
(60) days after the filing thereof); the appointment of a trustee or receiver to take possession of substantially all of Tenants assets located in the Leased Space or of Tenants interest in this Lease (unless possession is restored
to Tenant within thirty (30) days after such appointment); or the attachment, execution or levy against, or other judicial seizure of, substantially all of Tenants assets located in the Leased Space or of Tenants interest in this
Lease (unless the same is discharged within thirty (30) days after issuance thereof).

22. REMEDIES.

Upon the occurrence of any Event of Default by Tenant:

(a) Landlord may perform for the account of Tenant any such act, the omission of which constituted an Event of Default by Tenant and immediately recover as Additional Rent any expenditures made and the amount of any
obligations incurred in connection therewith, plus interest at the Default Rate from the date the obligations are incurred by Landlord until payment therefor to Landlord, whether before or after entry of judgment and issuance of execution thereon.

(b) Landlord may accelerate all Minimum Annual Rent and Additional Rent due for the balance of the Term of this Lease and declare the
same to be immediately due and payable. In determining the amount of any future payments due Landlord relating to Operating Expenses and/or Real Estate Taxes, Landlord shall make such determination based upon the most recent estimates of Operating
Expenses and/or Real Estate Taxes available.

(c) Landlord, at its option, may serve notice upon Tenant that this Lease and the then
unexpired term thereof shall cease and expire and become absolutely void on the date specified in such notice, to be not less than five (5) days after the date of such notice without any right on the part of the Tenant to save the forfeiture by
payment of any sum due or by the performance of any term or condition broken; and, thereupon and at the expiration of the time limit in such notice, this Lease and the Term hereof, as well as the right, title and interest of the Tenant hereunder,
shall wholly cease and expire and become void in the same manner and with the same force and effect (except as to Tenants liability) as if the date fixed in such notice were the date herein granted for expiration of the Term of this Lease.
Thereupon, Tenant shall immediately quit and surrender to Landlord the Leased Space, and Landlord may enter into and repossess the Leased Space by summary proceedings, detainer, ejectment or otherwise and remove all occupants thereof and, at
Landlords option, any property thereon, without being liable to indictment, prosecution or damages therefor. No such expiration or termination of this Lease



21



---

shall relieve Tenant of its liability and obligations under the Lease, whether or not the Leased Space shall be relet.

(d) Landlord may, at any time after the occurrence of any Event of Default, re-enter and repossess the Leased Space and any part thereof and attempt in
its own name, as agent for Tenant if this Lease not be terminated, or on its own behalf if this Lease be terminated, to relet all or any part of the Leased Space for and upon such terms and to such persons and for such period or periods as Landlord,
in its sole discretion, shall determine, including a term beyond the termination of this Lease; and Landlord shall not be required to accept any tenant offered by Tenant or observe any instruction given by Tenant about such reletting. For the
purpose of such reletting, Landlord may decorate or make repairs, changes, alterations or additions in or to the Leased Space to the extent deemed by Landlord desirable or convenient; and the cost of such decoration, repairs, changes, alterations or
additions shall be charged to and be payable by Tenant as Additional Rent hereunder, as well as any reasonable brokerage and attorneys fees incurred by Landlord; and any sums collected by Landlord from any new tenant obtained shall be credited
against the balance of the rent due hereunder as aforesaid. Tenant shall pay to Landlord monthly, on the days when the rent would have been payable under this Lease, the amount due hereunder less the amount obtained by Landlord from such new tenant.

(e) Landlord shall have the right of injunction, in the event of a breach or threatened breach by Tenant of any of the terms and
conditions hereof, to restrain the same and the right to invoke any remedy allowed by law or in equity, whether or not other remedies, indemnities or reimbursements are herein provided. The rights and remedies given to Landlord in this Lease are
distinct, separate and cumulative remedies; and no one of them, whether or not exercised by Landlord, shall be deemed to be in exclusion of any of the others.

(f) In the event of the occurrence of an Event of Default hereunder, Landlord shall have the right to change the locks on the Leased Space and exclude Tenant therefrom, and to discontinue all or part of the services
and facilities provided to Tenant under this Lease or otherwise, which-action shall not be deemed an eviction. Such action may be taken, however, only upon five (5) days prior notice to Tenant, and Tenant hereby releases Landlord from any
liability for any damages sustained by Tenant or its property as a result of the same.

(g) If Tenant has paid accelerated rent to
Landlord and Landlord thereafter re-lets any portion of the Leased Space, any sums collected by Landlord from any new tenant obtained in excess of the cost of decoration, repairs, changes, alterations or additions, and any reasonable brokerage and
attorneys fees incurred by Landlord in connection with such re-letting, to the extent the same exceed all other damages incurred by Landlord as a result of Tenants default, shall be paid to Tenant if, as and when received by Landlord from the
replacement tenant, but in no event shall the amount to be paid to Tenant by Landlord exceed the amount of accelerated rent and other damages paid by Tenant to Landlord.

(h) Following an Event of Default, Landlord agrees not to unreasonably withhold, delay or condition (including, for example, the requirement of any back-rent payments by Tenant) its consent to any subtenants or
assignees which Tenant may propose for all or any



22



---

portion of the Leased Space provided that Landlords acceptance of any such subtenant or assignee shall not be deemed to cure Tenants default nor
otherwise relieve Tenant of its obligations hereunder, unless Landlord otherwise agrees in writing. Any rent paid as a result of any such assignment or sublease shall be applied in accordance with subsection (g) above.

23. CONFESSION OF JUDGMENT FOR POSSESSION IN LIMITED CIRCUMSTANCE.

If Tenant fails to vacate the Leased Premises upon termination of this Lease or an Event of Default under Section 21(a) shall have occurred,
Landlord shall have the further remedy of confession of judgment for possession:

ANY PROTHONOTARY OR ATTORNEY OF ANY COURT OF RECORD
MAY APPEAR FOR TENANT TO FILE AN AGREEMENT FOR ENTERING IN ANY COMPETENT COURT AN AMICABLE ACTION FOR JUDGMENT EJECTMENT AGAINST TENANT AND ALL PERSONS CLAIMING UNDER TENANT, AND A JUDGMENT FOR THE RECOVERY BY LANDLORD OF POSSESSION MAY ISSUE
FORTHWITH WITHOUT ANY PRIOR WRIT OR PROCEEDINGS WHATSOEVER. IF FOR ANY REASON AFTER SUCH ACTION SHALL HAVE BEEN COMMENCED, IT SHALL BE CANCELED OR SUSPENDED AND POSSESSION OF THE LEASED SPACE REMAINS IN OR IS RESTORED TO TENANT, LANDLORD SHALL HAVE
THE RIGHT UPON ANY SUBSEQUENT DEFAULT OR TERMINATION OF THIS LEASE OR ANY RENEWAL OR EXTENSION HEREOF, TO BRING ONE OR MORE AMICABLE ACTIONS IN EJECTMENT AS HEREINBEFORE SET FORTH TO RECOVER POSSESSION OF THE LEASED SPACE. IF IN ANY AMICABLE ACTION
IN EJECTMENT, OR IN ASSUMPSIT FOR RENT OR CHARGES, LANDLORD SHALL CAUSE TO BE FILED IN SUCH ACTION AN AFFIDAVIT SETTING FORTH THE FACTS NECESSARY TO AUTHORIZE THE ENTRY OF JUDGMENT AND IF A TRUE COPY OF THIS LEASE (AND THE TRUTH OF THE COPY STATED
IN SUCH AFFIDAVIT SHALL BE SUFFICIENT PROOF) BE FILED IN SUCH ACTION, IT SHALL NOT BE NECESSARY TO FILE THE ORIGINAL AS A WARRANT OF ATTORNEY, ANY LAW, RULE OF COURT, CUSTOM OR PRACTICE TO THE CONTRARY NOTWITHSTANDING. TENANT EXPRESSLY RELEASES TO
LANDLORD, AND TO ANY AND ALL ATTORNEYS WHO MAY APPEAR FOR TENANT, ALL ERRORS IN THE SAID PROCEEDINGS, AND ALL LIABILITY THEREFOR.

24.
WAIVER.

The failure or delay on the part of either party to enforce or exercise at any time any of the terms and conditions
of this Lease shall in no way be construed to be a waiver thereof, nor in any way to affect the validity of this Lease or any part hereof, or the right of such party to thereafter enforce each and every such term or condition. No waiver by either
party of any breach of this



23



---

Lease shall be held to be a waiver of any other or subsequent breach. The receipt by Landlord of rent or the payment by Tenant of rent at a time when a
default exists under this Lease shall not be construed as a waiver of such default. The receipt by Landlord of a lesser amount than the rent due shall not be construed to be other than a payment on account of the rent then due, nor shall any
statement on Tenants check or any letter accompanying Tenants check be deemed an accord and satisfaction, and Landlord may accept such payment without prejudice to Landlords right to recover the balance of the rent due or to pursue
any other remedies provided in this Lease. No act or thing done by this Lease shall be deemed an acceptance or a surrender of the Leased Space, and no agreement to accept such a surrender shall be valid unless in writing and signed by the party
against whom enforcement is sought.

25. QUIET ENJOYMENT.

If and so long as Tenant pays the rent reserved hereunder and observes and performs all the terms and conditions on Tenants part to be observed and
performed hereunder, Tenant shall and may peaceably and quietly have, hold and enjoy the Leased Space for the entire Term hereof, subject to all of the provisions of this Lease.

26. FORCE MAJEURE.

Time
periods for performance of each partys obligations (including without limitation construction obligations) under any of the terms of this Lease shall be extended for periods of time during which performance is prevented due to circumstances
beyond the performing partys control, including without limitation, embargoes, governmental regulations, act of God, war or other strife, shortages or unavailability of materials or equipment which are special order items described
in the TI Plans or Change Orders, strikes, lockouts, adverse weather conditions, bankruptcy or breach of contract by a subcontractor (collectively, Force Majeure). Force Majeure events shall not, however, excuse any partys failure
to perform a monetary obligation which has arisen.

27. SUCCESSORS.

The respective rights and obligations provided in this Lease shall bind and shall inure to the parties hereto, and their successors and permitted assigns.

28.LANDLORDS LIABILITY.

Landlords responsibility under this Lease shall be limited to its interest in the Leased Space and in the Building, and no members of Landlords partnership shall be personally liable hereunder. Tenant
agrees to look solely to Landlords interest in the Leased Space and in the Building for the collection of any judgment, and, in entering any such judgment, the person entering the same shall request the prothonotary to mark the judgment index
accordingly. If the Leased Space or the Building is transferred or conveyed, Landlord shall be relieved of all covenants and obligations under this Lease thereafter accruing, provided that notice of said transfer or conveyance is given to Tenant by
Landlord.



24



---

29. SUBORDINATION.

Landlord represents that no Mortgage (hereafter defined) currently encumbers the Building, any part thereof, or the land on which it is
situate. Upon delivery of a nondisturbance and attornment agreement which is reasonably satisfactory to Tenant, this Lease is, and all of Tenants rights hereunder are and shall always be, subject and subordinate to any such mortgage, leases of
Landlords property (in sale-leaseback) pursuant to which Landlord has or shall retain the right of possession of the Leased Space (and/or the Building) or security instruments (collectively called Mortgage) that now exist, or may
hereafter be placed upon the Leased Space or the Building, or any part thereof and all advances made or to be made thereunder and extensions thereof, and if the holder of any such interest (Mortgagee) forecloses or extinguishes
Landlords rights in the Building or Leased Space, Tenant shall attorn to and recognize any such holder as the successor Landlord under this Lease. The aforesaid provision shall be self-operative and no further instrument or document shall be
necessary unless required by any such Mortgagee or purchaser. Notwithstanding anything to the contrary set forth above, any Mortgagee may at any time subordinate its Mortgage to this Lease, without Tenants consent, by execution of a written
document subordinating such Mortgage to this Lease to the extent set forth therein, thereupon this Lease shall be deemed prior to such Mortgage. Should Landlord or any Mortgagee or purchaser desire confirmation of either such subordination or such
attornment, as the case may be, Tenant upon written request, and from time to time, will execute and deliver without charge and in form reasonably satisfactory to Tenant, Landlord, to the Mortgagee or the purchaser all instruments and/or documents
that may be required to acknowledge such subordination and/or agreement to attorn, in recordable form within ten (10) business days following a request therefor from Landlord. The foregoing subordination and attornment provisions are subject to
the Mortgagees agreement that such Mortgagee agrees to recognize this Lease and to allow Tenant to remain in possession of the Leased Space and exercise all of its rights under the Lease so long as Tenant does not suffer an Event of Default
under this Lease and this Lease or Tenants right of possession is not terminated in accordance with the terms of this Lease.

30.
RULES AND REGULATIONS.

Tenant agrees to comply with the rules and regulations established by Landlord from time to time,
which Landlord agrees will be applied uniformly to all tenants; provided, however, that none of such rules and regulation materially and adversely affect Tenants rights hereunder or operation of Tenants Business from the Leased Space,
and Tenant is afforded a reasonable time from notice thereof to achieve compliance therewith. The existing rules and regulations are attached hereto as Exhibit E.

31. GOVERNING LAW.

This Lease
shall be governed by and construed in accordance with the laws of the state in which the Building is located.

32.
SEVERABILITY.



25



---

If any provisions of this Lease shall prove to be invalid, void or illegal, it shall in no way affect any
other provision hereof and the remaining provisions shall nevertheless remain in full force and effect.

33. NOTICES.

All notices and statements required or permitted under this Lease shall be in writing and delivered by either (a) United States
Registered or Certified Mail, return receipt requested, postage prepaid, (b) Federal Express or other nationally recognized overnight courier service, fee prepaid, or (c) hand delivery against written receipt therefor, in each case
addressed as follows:



|                                          |  |                                     |  | 
|----------------------------------------- |  | ----------------------------------- |  | 
|As to Tenant prior to Commencement Date:  |  | ViroPharma Incorporated             |  | 
|                                          |  | 397 Eagleview Boulevard             |  | 
|                                          |  | Exton, PA 19341                     |  | 
|                                          |  | Attention: General Counsel          |  | 
|                                          |  |                                    
|As to Tenant as of the Commencement Date: |  | ViroPharma Incorporated             |  | 
|                                          |  | Eagleview Corporate Center          |  | 
|                                          |  | 730 Stockton Drive                  |  | 
|                                          |  | Exton, PA 19341                     |  | 
|                                          |  | Attention: General Counsel          |  | 
|                                          |  |                                    
|As to Landlord:                           |  | 730 Stockton Drive Associates, L.P. |  | 
|                                          |  | P.O. Box 562                        |  | 
|                                          |  | 707 Eagleview Boulevard             |  | 
|                                          |  | Eagleview Corporate Center          |  | 
|                                          |  | Exton, PA 19341                     |  | 
|                                          |  | Attention: General Partner          |  | 

Either party may at any time, in the manner set forth for giving notices to the other, designate a
different address to which notices to it shall be sent. Notice given in accordance with this Section shall be deemed given and received as of the earlier of (i) actual receipt or (ii) first attempted delivery which is refused (as opposed
to being returned for insufficient postage/fee, improper address or like cause).

34. BROKERS.

Tenant represents and warrants to Landlord that Tenant has not dealt with any broker, firm, company or person in connection with the negotiation for or
the obtaining of this Lease, and each party shall indemnify, defend and hold harmless the other from and against any claim by any person claiming a commission or other form of compensation by virtue of having dealt with



26



---

such party with regard to this Lease, and any attorneys fees or other expenses incurred by the other party in connection therewith.

35. SIGNS.

Tenant shall not,
without the prior written consent of Landlord, paint, place or erect any sign on the exterior doors or walls of the Leased Space or of the Building or Center. Subject to applicable zoning requirements and Landlord and Tenants mutual agreement
on sign graphics not to be unreasonably withheld, Tenant shall have the right to maintain signs on the Real Estate (hereafter defined in Section 44(a)(i)) as follows: (a) two monument signs of the size and at the current location as
exist and face Stockton Drive, each of which monument signs have columns at each side which are approximately 19.5 inches wide and 63.5 inches high, which columns surround a monument approximately 97 inches wide by 51.5 inches high; and (b) a
building entry sign a maximum of 36 inches wide by 22 inches high at the Buildings main entry door. Landlord shall install the building address on the monument signs at its expense, and install the Tenants name and/or logo on each of the
monument signs at Tenants expense, subject to a $1500.00 allowance which Landlord will provide Tenant for both signs toward the cost of installing the Tenants name and/or logo. Landlord will supply the sign plate for the building
entrance sign, but Tenant shall bear the cost of all graphics bearing Tenants name and/or logo. Landlord shall be responsible to obtain approval from the Association with respect to such signage and, as declarant under the Covenants, hereby
(i) approves the size of the signs described herein, and (ii) agrees not to unreasonably withhold its consent to the sign graphics on either sign as long as same is reasonably compatible with other business signage located within the
Center. In addition, Landlord shall install at its expense vinyl lettered signs on any unused entry doors at the front of the Building indicating that such doors are not entrances to the Building.

36. SECURITY DEPOSIT.

(a)
Upon the execution of this Lease, Tenant agrees to deposit with Landlord, the sum of $137,000.00 to be held by Landlord as security for the faithful performance of all the terms and conditions of this Lease (Security Deposit). The
Security Deposit shall be paid directly to Landlord. Should the Tenant breach any of the terms and conditions of this Lease which continues beyond any applicable cure period and required notice, Landlord shall have the right, at any time, to apply
the Security Deposit or any part thereof, for the purpose of curing any such default or for the purpose of reimbursing Landlord for any damage or costs occasioned by such default, but the right of Landlord to apply the Security Deposit shall not
affect any other remedies available to Landlord under this Lease or under applicable law. If the Security Deposit, or any part thereof, is so applied by Landlord, Tenant shall, within ten (10) days after demand, deposit additional funds with
Landlord to restore the Security Deposit, and failure to do so shall constitute an event of default under this Lease.

(b) If the Tenant
shall have complied with all material terms and conditions of this Lease at the expiration of this Lease, the Security Deposit (without interest and amounts properly withdrawn by Landlord and not refunded by Tenant) shall be refunded to Tenant
within thirty (30) days after the expiration or sooner termination of this Lease (including without limitation



27



---

permitted terminations hereunder and terminations due to Landlords default which continues beyond applicable grace and cure periods following notice
where applicable); provided, however, that Tenant first shall have vacated the Leased Space and surrendered possession thereof to the Landlord by delivery of keys, in accordance with the Lease provisions and shall have returned the Leased Space to
Landlord in the condition required hereunder.

(c) Nothing herein contained shall require Landlord to hold the sums so deposited as a trust
fund, nor establish any relationship other than that of debtor and creditor with respect to said funds so deposited.

(d) If Landlord shall
assign or otherwise transfer its interest in this Lease, Landlord shall transfer the Security Deposit to the assignee or other transferee of such interest (with like obligation to transfer to any subsequent assignee or other transferee), and upon
such transfer, Landlord shall be released and relieved from all liability and/or responsibility with respect to this Security Deposit and/or the return or application thereof.

37. USE OF INFORMATION IN ADVERTISING.

Landlord and any agent employed by Landlord shall be permitted to utilize the name of Tenant and any occupant or user of the Leased Space, and other general information about the Tenant and such occupant or user, and the terms of this
Lease, in advertising and promotional material utilized by them.

38. CAPTIONS.

The title to paragraphs of this Lease are for convenience of reference only, and are not to be construed as defining, limiting or modifying the scope or
intent of any of the terms and conditions of this Lease.

39. ENTIRE AGREEMENT.

This Lease contains all covenants and agreements between Landlord and Tenant relating in any manner to the rental, use and occupancy of the Leased Space
and Tenants use of the Building and other matters set forth in this Lease. No prior agreement or understanding pertaining to the same shall be valid or of any force or effect and the terms, covenants and conditions of this Lease shall not be
altered, modified or added to except in writing signed by Landlord and Tenant.

40. ACCESS TO THE LEASED SPACE AND COMMON
AREAS.

Tenant shall have access to the Leased Space and common areas of the Building 24 hours a day, 365 days per year.

41. ATTORNEY FEES.



28



---

The prevailing party in any litigation or arbitration to enforce any obligation under this Lease shall be
entitled to have reimbursed by the other party all reasonable costs of collection and fees for legal counsel incurred as a result of enforcing or protecting any rights under this Lease.

42. SELF-HELP.

(a) If
Landlord fails to fulfill its obligations under this Lease, Tenant shall notify Landlord of such non-performance. Except in the case where immediate response is required to avoid physical damage to the Leased Space or persons or Tenants
property therein, Landlord shall have thirty (30) days to cure such nonperformance. If Landlord fails to complete cure within such thirty (30) days after receipt of such notice from Tenant, Tenant shall have the right, but not the
obligation, to carry out such activities on behalf of Landlord so as to cure such nonperformance. Landlord shall reimburse Tenant for all reasonable costs, fees and expenses incurred by Tenant in connection with performing such cure. Such
reimbursement shall be made within fifteen (15) days after written demand by Tenant, which demand shall be accompanied by appropriate invoices or other materials to substantiate the amount for the requested reimbursement. If Landlord fails to
pay Tenant the amount requested within said fifteen (15) day period, such unpaid amounts shall accrue interest at the Default Rate which shall continue to accrue on any judgment obtained by Tenant against Landlord for recovery of such
unreimbursed amounts. Notwithstanding the foregoing rights, Tenant shall not be entitled to set-off such amounts against Rent due hereunder, and Tenant hereby expressly waives such right, unless and until Tenant shall have obtained a final judgment
against Landlord with respect to Landlords obligation under the Lease which Tenant alleges that Landlord failed to perform, and such right of set-off shall be applicable only to the amount of the judgment not paid within thirty (30) days
and may be asserted by Tenant against installments of Rent thereafter coming due.

(b) Amounts due from Landlord to which the Default Rate
has been applied shall continue to accrue interest at the Default Rate after entry of judgment and issuance of execution thereon until paid in full.

43. MEMORANDUM OF LEASE.

Tenant, at its expense, shall be entitled to record a memorandum of
lease which Landlord shall execute and acknowledge. Concurrently with the execution of this Lease, Tenant and Landlord agree to execute such memorandum of lease along with a termination thereof, both of which shall be in form and substance
sufficient to permit the recording of such instrument and otherwise reasonably acceptable to Landlord and Tenant. The termination of such memorandum of lease shall be held in escrow by Riley, Riper, Hollin & Colagreco, as escrow agent,
until termination of this Lease, pursuant to a separate escrow agreement with respect to which the parties agree to negotiate in good faith promptly upon or following execution hereof. In the absence of such escrow agreement, the party designated as
escrow agent shall hold such termination until the earlier of (a) receipt of a court order directing release of said termination or



29



---

(b) written instructions from Landlord and Tenant directing the release of said termination. Landlord shall cause its affiliates which own the Adjacent Land,
Lot 11 and the Southwest Parcel (as defined in Section 46 below) to execute and acknowledge the foregoing memorandum and termination with respect to the Adjacent Land and Southwest Parcel.

44. LANDLORD REPRESENTATIONS AND WARRANTIES.

(a) Landlord, to induce Tenant to enter into this Lease, represents, warrants and agrees, as of the date first set forth above and the Commencement Date, as follows, which representations and warranties shall survive
until one (1) year after the Building and Leased Space are Substantially Completed:

(i) Title to the Property. To
Landlords Knowledge, Landlord owns the Land upon which the Building has been constructed and has good and marketable title of record thereto, free of any liens or encumbrance except for the Permitted Title Exceptions described on Exhibit
F hereto. Landlords ownership of the Land has never been challenged. No parties other than Landlord are required to execute or consent to this Lease.

(ii) No Third Party Rights. There are no options, licenses, leases, rights of first refusal, contracts for the sale of the Real Estate (including
conditional sales agreements) or similar arrangements respecting the Real Estate other than as are to be entered with Tenant.

(iii)
Condemnation. Landlord has not received any notice or other communication from any governmental unit or other body having the power of eminent domain indicating that any part of the Land or other portion of Eagleview Corporate Center has
been, will or may be condemned.

(iv) Proceedings. No action, suit, or proceeding currently is pending against the Real Estate or,
to Landlords Knowledge, any other portion of Eagleview Corporate Center in any court or before any board, commission agency or other governmental instrumentality. Landlord has not received written notice of any such threatened action, suit, or
proceeding.

(v) Assessments: Public Improvements. No assessments or notice of assessments for public improvements have been made
against the Land prior to the date of this Lease which have not been paid, other than impact fees which will be paid by Landlord, and no work has been commenced on new public improvements authorized by ordinances enacted prior to the date hereof
which will result in an assessment against the Land.

(vi) Zoning and Approvals. The Land is zoned planned commercial/industrial.
All subdivision and land development approvals necessary for the creation of the Land as a separate lot with direct access to a public road (collectively Approvals) have been obtained and are in full force and effect as of this date.
Landlord is in full compliance with all Approvals and, to Landlords Knowledge, no condition or state of facts



30



---

now exists which, with the giving of notice or expiration of applicable time period, could cause the invalidation, termination or revocation of any of the
Approvals.

(vii) Flood Plain. To Landlords Knowledge, no portion of the Land is located within a special flood hazard area
as documented in the Department of Housing and Urban Development, Federal Insurance Administration Special Flood Hazard Area Maps.

(viii) Environmental.

(A) Environmental Reports. Landlord has delivered to Tenant a true, correct and complete copy of the
environmental report titled Environmental Site Assessment Eagleview Corporate Center by SMC Martin, which bears the reference number 9388-88100(2.0) and date of March 16, 1989 (Environmental Report). The Environmental Report covers
the Land, and, to Landlords Knowledge, no facts or circumstances have changed at the Land which would make any potion of the Environmental Report incorrect or misleading. In the event there is found, through a Phase 1 environmental site
assessment being obtained by Tenant (the New Phase 1 Report), any adverse environmental condition which in Tenants reasonable judgment will preclude its use of the Leased Space for Tenants Business, or which will expose
Tenant to liability for remediation of existing environmental hazards identified in the New Phase 1 Report, which liability Landlord will not assume in a manner satisfactory to Tenant, then Tenant may terminate this Lease by written notice delivered
to Landlord not later than two (2) business days after receipt of the New Phase 1 Report.

(B) Compliance; Permits. To
Landlords Knowledge, as of the date of this Lease, the Land is in compliance with all applicable Federal, state and local laws, regulations, ordinances, rulings , and directives relating to protection or regulation of the environment
(Environmental Laws) and with any permit or governmental authorization which relate to the Environmental Laws.

(C)
Underground Storage Tanks. To Landlords Knowledge, no underground storage tanks are located on the Land nor have any underground storage tanks been removed from the Land.

(ix) Utilities. The following utilities currently service the Real Estate (or are available to service the Land with appropriate connections):
water, sewer, gas, telephone, electricity and conduits for fiber optics and cable. All approvals required for any necessary connections have been obtained and remain in full force and effect. All such utilities are available currently at the
Building and are available without any limitation or allocation imposed by the utility provider or applicable governmental authorities with the exception of sewer effluent limitations.

(x) Covenants. The Amended and Restated Declaration of Easements and Protective Covenants recorded in Deed Book 2074 at Page 240 as amended by a
Supplement and Clarification recorded in Deed Book 2363, page 499, a First Amendment recorded in Deed Book 2596, page 550, a Second Amendment recorded in Deed Book 3590, page 1986, a Third



31



---

Amendment recorded in Deed Book 3672, page 579 and a Fourth Amendment recorded on Deed Book 4177, page 2306, a Fifth Amendment recorded in Record Book 4206
Page 1534, a Sixth Amendment recorded in Record Book 4365 Page 649, a Seventh Amendment recorded in Record Book 4744 Page 0278, and an Eighth Amendment recorded in Record Book 7006, page 2299 (collectively, Declaration) constitutes all
of the protective covenants or similar agreements which effect Eagleview Corporate Center. Landlord represents and covenants that no private agreements exist which materially and adversely affect Tenants rights under this Lease or an
owners rights under the Declaration, including the ability to seek enforcement thereof, nor will Landlord hereafter enter into any such agreement.

(xi) Discovery of Facts. If, prior to the Commencement Date, Landlord acquires actual knowledge of any fact which would be required to be disclosed by Landlord to render its representations and warranties true,
correct and complete, in all material respects, Landlord promptly shall disclose such fact to Tenant.

(b) For purposes of this
Section 44, the term (and similar terms) to Landlords Knowledge shall mean to the best knowledge of Landlords President, Executive Vice President and Director of Commercial Marketing (including without limitation
knowledge deemed to be charged to Landlord by virtue of items and facts disclosed in the reports of consultants in Landlords possession wherever located) such statement or fact is true and correct and such persons possess no information which
make such statement or fact incomplete or misleading.

45. RENEWAL OPTION.

(a) Tenant shall have the right and option to extend the term of this Lease for two (2) consecutive renewal terms, each of five (5) years
duration. The first renewal term, if exercised, shall commence on the day immediately following the expiration of the Initial Term hereof, and the second renewal term, if exercised, shall commence on the date immediately following the expiration of
the first renewal term. The option to extend, as well as the commencement of each renewal term, shall be conditioned on no uncured Events of Default by Tenant then existing.

(b) Tenant shall exercise each renewal option only by delivering written notice of same to Landlord not later than one (1) year prior to the
expiration of the then current term. Tenants failure to timely exercise an option shall be deemed a waiver of all rights under this Section, in which event this Lease shall terminate upon expiration or earlier termination of the then current
term.

(c) Each renewal term, if exercised, shall be upon all of the terms and conditions of this Lease, except for provisions which, by
their nature, are limited to the Initial Term and for the change in Minimum Annual Rent which (i) for the first renewal term, if exercised, shall be the greater of $17.30 per rentable square foot or the FMRV determined in accordance with
subsection (d) below and (ii) for the second renewal term, if exercised, shall be



32



---

the greater of the rate per rentable square foot during the final year of the first renewal term, or the FMRV determined in accordance with subsection
(d) below.

(d) Fair Rental Value Calculation. The FMRV shall mean the fair market rental rate per square foot of rentable
area per year, calculated at the time of the determination of the FMRV and based on leases within Chester County for comparable space under comparable terms within comparable buildings at the time in question. Subject to the foregoing, the FMRV
shall be determined as follows:

(i) Not later than three (3) months nor sooner than six (6) months prior to the commencement of
a renewal term, Landlord shall notify Tenant in writing of Landlords estimate of the FMRV. Within ten (10) business days following Landlords notice of the FMRV, Tenant, by written notice to Landlord, either will accept
Landlords statement of the FMRV or notify Landlord of Tenants estimate of the FMRV, if different from that set forth in Landlords notice. In the absence of such timely notice by Tenant to Landlord, Tenant will be deemed to have
accepted Landlords statement of FMRV. If Tenant shall furnish a counter-estimate of the FMRV, Landlord, by written notice to Tenant within ten (10) business days after Landlords receipt of Tenants estimate, either may accept
Tenants estimate in writing or, without prejudice to any position, suggest alternative figures for the FMRV which are greater than Tenants estimate thereof and less than Landlords initial statement. In the absence of such timely
notice by Landlord to Tenant, Landlord will be deemed to have accepted Tenants statement of FMRV. If Landlord and Tenant shall not have an agreement as to the FMRV within thirty-five (35) days following Tenants written notice to
Landlord exercising a renewal right, FMRV shall be determined by appraisal as set forth in subsection (ii) below.

(ii) If
FMRV is to be determined by appraisal, such determination shall be by an appraiser who is a member of the American Institute of Real Estate Appraisers or its successor organization holding the M.A.I. designation, and who is agreed upon by Landlord
and Tenant. If Landlord and Tenant are unable to agree upon an appraiser within the time period specified in subsection (i) above, then, within five (5) business days thereafter, each shall appoint a M.A.I. appraiser and the FMRV
shall be the FMRV determined by such appraisers or the average thereof if their respective appraisals differ by ten percent (10%) or less. If either party shall fail to appoint an appraiser within the time provided, the FMRV determined by the
appraiser timely appointed shall be the FMRV. If the appraisals delivered by the appraisers appointed by Landlord and Tenant differ by more than ten percent (10%), the appraisers so appointed shall appoint a third M.A.I. appraiser and the FMRV shall
be the average of the appraisal delivered by the third appraiser and whichever of the appraisals previously delivered by the appraisers appointed by Landlord and Tenant is closer to the appraisal of the third appraiser. If the two appraisers are
unable to agree upon a third appraiser within ten (10) days from the date the later of their two appraisals is delivered, such appointment, on application by either Landlord or Tenant, will be made by the then President of the Real Estate Board
for Chester County or, if such person is unwilling or unable to make such appointment, by the American Arbitration Association or its successor organization acting through its office in Philadelphia or by its office located closest to Philadelphia.
Landlord and Tenant each shall pay the fees and expenses of the respective appraiser appointed by each of them and shall pay in equal shares the fees and



33



---

expenses of the appraiser mutually agreed upon by Landlord and Tenant, or as may be appointed by the first two appraisers, the then President of the Real
Estate Board for Chester County or the American Arbitration Association or its successor, as applicable.

(iii) The determination of FMRV
in accordance with this Section shall be conclusive and binding on Landlord and Tenant.

46. EXPANSION OPTION FOR ADJACENT
BUILDINGS

(a) For the purpose of this Section, the term Landlord shall mean either Landlord or any affiliate of
Landlord which owns property adjacent to the Building, such adjacent property being a lot consisting of approximately 9 acres, more or less at the end of Arrowhead Drive with frontage on the Pennsylvania Turnpike, (Adjacent Land), on
which Adjacent Land Landlord expects to obtain development approval for a building of approximately 62,000 rentable square feet designated as 4 on the plan attached hereto as Exhibit G(the Adjacent Land Building), and
the Southwest Parcel (as defined in subsection (b) below, as applicable. In addition, on Lot 11 Landlord has obtained development approval for two flex buildings, one of which is approved for 26,000 square feet designated as
2 on Exhibit G, and one of which is approved for 32,000 square feet designated as 3 on Exhibit G (collectively the Lot 11 Buildings), as such buildings are also depicted on the approved land
development plan for Lot 10 attached hereto as Exhibit H. If Landlord desires to lease or sell all or a portion of the 32,000 square foot Lot 11 Building or the Adjacent Land Building (collectively the ROFO Buildings), Landlord
shall notify Tenant of such decision in writing (Availability Notice), and within ten (10) business days thereafter, Tenant shall notify Landlord in writing whether it desires to negotiate a lease or purchase of one or both of the
ROFO Buildings from Landlord. If Tenant so notifies Tenant that it desires to negotiate a lease or purchase of the ROFO Building so designated, Landlord shall provide to Tenant a non-binding, written lease or sale proposal, as applicable
(Landlords Term Sheet). Tenant shall, within ten (10) business days following receipt of Landlords Term Sheet, advise Landlord whether it desires to enter into a lease or agreement of sale and purchase on the terms
contained in the Landlords Term Sheet. If (A)Tenant rejects or fails to respond to the Availability Notice or Landlords Term Sheet within the applicable period specified above, or (B) Landlord and Tenant do not execute a lease or
agreement of sale and purchase, as applicable, for the ROFO Building within thirty (30) days after Tenants receipt of Landlords Term Sheet, Landlord shall be entitled to lease or sell the ROFO Buildings, or any portion thereof, free
and clear of any rights of Tenant under this Section. A condition to Tenants exercise of its rights under this Section shall be that no outstanding notice of default exists under this Lease at each time of exercise.

(b) In addition, the land located to the west of Lot 11 designated as Southwest Parcel on Exhibit G(Southwest Parcel)
will support development of three buildings located thereon as depicted on Exhibit G, although Landlord has not yet obtained plan approvals for such buildings.At such time as the remaining square footage available to be leased or sold
on the Southwest Parcel, whether in buildings constructed or available to be constructed,



34



---

is reduced to 80,000 square feet (collectively the Minimum ROFR Availability), and if at such time Tenant has not leased or purchased any portion
of a ROFO Building, Tenant shall have a right of first refusal to lease any space within a building which contains or will contain the Minimum ROFR Availability (the ROFR Space) or purchase such building (a ROFR Building) in
accordance with the following procedures.

(i) If Landlord desires to issue a proposal to sell or lease the ROFR Space or an ROFR Building
on terms acceptable to Landlord, or Landlord has received a proposal for purchase or lease which Landlord desires to accept, Landlord shall notify Tenant of such decision in writing (Offer Notice) and shall offer to Tenant the
opportunity to lease the ROFR Space or purchase the ROFR Building described in such Offer Notice on the same terms and conditions set forth in the Offer Notice. The Offer Notice shall be accompanied by a written lease or sale proposal from Landlord
and shall otherwise include all relevant information as to the terms of such offer. Tenant shall have fifteen (15) business days after receipt of the Offer Notice to notify Landlord in writing that it will lease the ROFR Space or purchase the
ROFR Building from Landlord.

(ii) If (A)Tenant rejects or fails to respond to the Offer Notice within the applicable period specified in
subsection (i) above, or (B) Landlord and Tenant, despite reasonable, good faith efforts, do not execute a lease for the ROFR Space or agreement of sale and purchase for the ROFR Building, as applicable, within thirty (30) days after
Tenants exercise of its rights hereunder, Landlord shall be entitled to lease the ROFR Lease or sell the ROFR Building pursuant to the applicable Offer Notice, upon substantially the same terms and conditions set forth in the Offer Notice;
provided, however, that no such lease or sale shall be made on other terms materially less favorable to Landlord than the terms set forth in the Offer Notice. If Landlord has not so leased the ROFR Space or sold the ROFR Building, as applicable, on
the terms specified in the Offer Notice (or on terms materially more favorable to Landlord) within nine (9) months from delivery of the Offer Notice with respect to a sale, and within six (6) months from delivery of the Offer Notice with
respect to a lease, Landlord shall not thereafter offer to lease the ROFR Space or sell the ROFR Building, as applicable, to any party (including the offeror named in the Offer Notice) without again complying with the provisions of this
Section 46(b). All terms of this Section 46 shall apply to such revised Offer Notice, including Tenants opportunity to respond to the revised Offer Notice within the applicable period specified above. If Landlord executes the lease
or agreement of sale and purchase with a third party contemplated by the Offer Notice within the parameters permitted by this subsection, Tenants rights hereunder shall be null and void as to the ROFR Space so leased or the ROFR Building so
sold, but, in the case of a lease of less than the entire ROFR Building, shall continue to apply to the balance of the ROFR Building not leased. Otherwise, Tenants rights hereunder shall expire with the termination of this Lease, as renewed.

(iii) Landlord covenants that it shall not develop, nor permit its affiliate to develop, the balance of the Center which it owns in any
manner during the period that this subsection (b) remains in effect, which could result in the buildings available to be developed on the Southwest Parcel being less than 80,000 square feet.



35



---

(c) Condition to Exercise of Rights. A condition to Tenants exercise of its rights under
this Section shall be that no outstanding notice of a default by Tenant exists under this Lease at each time of exercise. The failure of such condition with respect to any one exercise of Tenants rights shall not preclude Tenants further
exercise of its rights.

(d) Any provision in this Section 46 with respect to the right to purchase a ROFO Building or ROFR Building
shall be inapplicable with respect to any portfolio sale of 500,000 square feet or more of Landlords and its affiliates buildings in the Center, but the terms and conditions of this Lease, including Tenants rights under this
Section 46, shall survive any portfolio sale.

47. LANDLORDS SUBORDINATION.

Landlord agrees to execute a commercially reasonable subordination agreement pursuant to which Landlord agrees to subordinate any statutory or common law
landlords lien to a security interest in Tenants personal property located in the Leased Space which is granted to a bank or other financial institution acquiring such security interest to secure a credit facility provided to Tenant
required by Tenant to finance acquisition of Tenants personal property or working capital.

IN WITNESS WHEREOF, the parties have
caused this Lease to be duly executed the day and year first above written, intending to be legally bound hereby.

[Signatures contained
on the following page]



36



---

LANDLORD:730 Stockton Drive Associates, L.P.By:

730 Stockton Drive Associates, Inc., its general partnerBy:

/s/ Robert S. HankinRobert S. Hankin, PresidentTENANT:VIROPHARMA INCORPORATEDBy:

/s/ Michel de RosenName:

Michel de RosenTitle:

President and Chief Executive Officer




37