Exhibit 10.1



DEVELOPMENT AND SUPPLY AGREEMENT



This AGREEMENT is made and entered into this 20th day of August, 2003 (the Effective Date) by and between
Sigma-Aldrich Fine Chemicals, a division of Sigma-Aldrich, Inc. having a principal place of business at 3050 Spruce Street, St. Louis, Missouri 63103, (SAFC) and GlycoGenesys, Inc., having a principal place of business at 31 St. James
Avenue, Boston, Massachusetts 02116 (Client). Both SAFC and Client are referred to herein individually as Party and collectively as the Parties.



WITNESSETH THAT:



WHEREAS, SAFC has expertise, personnel, the facility for, and experience in manufacturing components for pharmaceutical products and is willing to provide
such services to client companies in the pharmaceutical area and;



WHEREAS, Client has a commercial interest in the manufacture of the Product as hereafter defined and requests the services of SAFC in the manufacturing of such Product pursuant to the Project Charter and SAFC desires to manufacture such
Product on behalf of Client pursuant to such Project Charter and in accordance with the terms and conditions contained herein;



NOW, THEREFORE, in consideration of the premises and the mutual covenants and agreements contained herein, the Parties agree as follows:



ARTICLE 1

DEFINITIONS



|1. |  | As used in this Agreement, the following definitions shall apply:
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| | 1.1 |  | Act shall mean the U.S. Food, Drug and Cosmetic Act of 1934, the Public Health Service Act of 1944 and the regulations promulgated thereunder, as the same may be amended
from time to time.
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| | 1.2 |  | Active Pharmaceutical Ingredient or API shall mean the active pharmaceutical ingredient of the Product.
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| | 1.3 |  | Affiliate shall mean any corporation or non-corporate business entity, which directly or indirectly controls, is controlled by, or is under common control with a Party.
A corporation or non-corporate business entity shall be regarded as in control of another corporation if it owns or directly or indirectly controls at least fifty percent (50%) of the voting stock of the other corporation or (a) in the absence of
the ownership of at least fifty percent (50%) of the voting stock of a corporation or (b) in the case of a non-corporate entity, the power to direct or cause the direction of the management and policies of such corporation or non-corporate entity,
as applicable.
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| | 1.4 |  | Batch or Lot shall mean, with respect to Product, each separate and distinct quantity of Product processed under continuous conditions and designated by a
batch or lot number.
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| | 1.5 |  | cGMP Regulations means Current Good Manufacturing Practices as defined from time to time under the Act, as codified in 21 CFR Parts 210 and 211 and being currently
utilized within the pharmaceutical industry to manufacture the applicable type of Product(s).
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| | 1.6 |  | Certificate of Analysis or COA shall mean a document certifying a Batch or Lot of Product meets all established and mutually agreed upon Specifications as
referenced, signed and dated by a duly authorized representative of the Quality Control or Quality Assurance Department of SAFC or Client as the case may be.
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| | 1.7 |  | Confidential Information shall mean any nonpublic information of SAFC or Client that will be communicated to the other Party including without limitation, trade secrets,
business methods, operating procedures, manufacturing methods and processes, prices, and customer information, whether of a written, oral, visual or electronic nature, including but not limited to any such nonpublic information that may have been
disclosed between the SAFC and Client f/k/a SafeScience, Inc. from the date of that certain Confidential Disclosure Agreement dated April 15, 1999, as amended through and including the term of this Agreement.
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| | 1.8 |  | FDA shall mean the United States Food and Drug Administration.
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| | 1.9 |  | Intellectual Property shall mean property that can be protected under federal law, including copyrightable works, ideas, discoveries, and inventions.
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| | 1.10 |  | Product shall mean Sigma Product No. G7665GCS-100 Liquid Bulk Intermediate.
| | ---- |  | ------------------------------------------------------------------------------



| | 1.11 |  | Project Charter shall mean a written document or documents as agreed to by the Parties, describing the activities required to develop and manufacture the Product. The
Project Charter will be consolidated within a single attachment in Exhibit A to this Agreement.
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| | 1.12 |  | Quality Agreement shall mean a written document, mutually agreed to by the Parties, describing the obligations of the Parties with regards to compliance, quality
systems, and testing and release of the Product. The Quality Agreement will be attached as Exhibit B to this Agreement.
| | ---- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 1.13 |  | Regulatory Authority shall mean any federal, state, local, or international regulatory agency, department, bureau, or other governmental agency having jurisdiction over
the manufacture, sale, or distribution of Product, including but not limited to the Canadian Health Protection Branch, the European Medicines Evaluation Agency, the U.S. Food and Drug Administration, and Regulatory Authorities shall mean
collectively all such regulatory authorities.
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| | 1.14 |  | Specially Regulated Waste shall mean any Product refuse, remainder, residue, waste water or other discard material, including solid, liquid, semisolid, or contained
gaseous material that arises from the manufacture of the Product(s) which may be subject to or require special handling, treatment, storage, or disposal under any federal, state or local laws or regulations.
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| | 1.15 |  | Specifications shall mean (1) the performance parameters for which Product, ingredients and packaging components must comply to be considered acceptable and (2) the
written record of such Product performance parameters annexed hereto within the applicable Project Charter attachment. Specifications may be amended from time to time by written agreement of the Parties.
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| | 1.16 |  | Clients Technology Package shall mean such technical information to be supplied by Client to SAFC to enable SAFC to carry out its obligations hereunder. Items
which may be included in the Technology Package include, but is not limited to, Clients raw material and manufacturing component specifications, intermediate and product specifications, analytical and microbiological method validation reports,
analytical method transfer protocols, filter validation reports, raw material, intermediate and product storage specifications.
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| | 1.17 |  | Third Party shall mean any party other than Client or SAFC and their respective affiliates.
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ARTICLE 2

PRODUCT DEVELOPMENT



|2. |  | The Parties agree to the following provisions regarding Product Development:
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| | 2.1 |  | Client and SAFC shall jointly prepare and agree to in writing a Project Charter document, which may be amended from time to time as defined herein, for the Product, which shall, at
a minimum, incorporate the following:
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| | 2.1.1 |  | the Product development schedule;
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| | 2.1.2 |  | the stages in which the Project Charter is to be carried out (if any) and whether the commencement of each stage is dependent on successful completion of the previous stage;
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| | 2.1.3 |  | identify the facilities, staffing, supplies, and equipment required for the Project Charter and who (Client or SAFC) is responsible for providing each of such items;
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| | 2.1.4 |  | identify which Party is responsible for performing the various tasks or stages of the Project Charter;
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| | 2.1.5 |  | Specifications as defined in Section 1.15;
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| | 2.1.6 |  | a set of objective criteria whereby it can be assessed whether the Project Charter (and any stages thereof) has achieved its objectives;
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| | 2.1.7 |  | identify all documents (Clients Technology Package) and the timeline for delivery of such documents by Client to SAFC.
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| | 2.1.8 |  | identify all documents (including regulatory documents) and other deliverables to be provided by SAFC to Client; and
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| | 2.1.9 |  | a good faith estimate of the number of Batches or Lots required to complete the Project Charter.
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| | 2.1.10 |  | define Project Charter prices; and
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| | 2.1.11 |  | define Project Charter payment schedule in accordance with applicable milestones.
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| | 2.2 |  | SAFC shall respond in a timely manner to Clients inquiries regarding the status of any Project Charter.
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| | 2.3 |  | SAFC and Client may from time to time negotiate in good faith changes to any Project Charter:
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| | 2.3.1 |  | If such changes require SAFC to perform additional work or repeat work outside the original scope of the project, and such additional work is not required due to SAFCs fault
or negligence, SAFC and Client shall negotiate in good faith the price and timing for such additional work.
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| | 2.4 |  | Each Party shall provide the other Party, in a timely fashion, with all relevant information, documentation, and data necessary or appropriate for the Parties performance
hereunder. Except as explicitly otherwise provided in this Agreement, in the event a Party is to review or approve any information, documentation, data, or other materials supplied by the other Party, such review or approval shall be completed
within five (5) business days, unless additional time is requested based on a reasonable explanation provided within five (5) business days of the initial request.
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| | 2.5 |  | Each Party shall use its commercially reasonable best efforts to successfully complete the Project Charter. However, the Parties agree and understand that neither Party hereto
guarantees that the project will be successful or conducted in accordance with the project timetable nor warrants nor guarantees that a marketable product will result from the project.
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| | 2.6 |  | SAFC shall have the right to review those portions of Clients proposed regulatory submissions relating to SAFCs facilities or procedures before the submissions are filed
with Regulatory Authorities. SAFC shall complete its review of such submissions within ten (10) business days after receipt. SAFC shall consult with and advise Client in responding to questions from Regulatory Authorities regarding regulatory
submissions for the Product.
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| | 2.7 |  | Right of Negotiation to Manufacture: Subject to right which may be granted by Client to third parties in connection with collaborative development and marketing arrangements, prior
to commencing negotiations with any third party regarding the commercial manufacture of the Product, Client shall commence good faith negotiations regarding the same with SAFC.
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ARTICLE 3

INTELLECTUAL PROPERTY RIGHTS



|3. |  | The Parties agree to the following provisions regarding Intellectual Property Rights:
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| | 3.1 |  | Ownership: The Parties agree that: (a) Client shall retain all of its ownership rights in and to Clients Intellectual Property, (b) SAFC shall retain all of its ownership
rights in and to SAFCs Intellectual Property; (c) Client shall own all inventions made or conceived solely by Client; (d) SAFC shall own any inventions made or conceived solely by SAFC without utilizing the Confidential Information of
GlycoGenesys, and (e) Client shall own any inventions made or conceived jointly by the Parties in connection with the performance of this Agreement or by SAFC utilizing the Confidential Information of GlycoGenesys.
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| | 3.2 |  | License Grants: Client hereby grants to SAFC a nonexclusive, worldwide, royalty-free license during the term of this Agreement to use such Client Intellectual Property rights as are
necessary for SAFC to perform SAFCs obligations under this Agreement. SAFC hereby grants to Client a nonexclusive, worldwide, royalty-free, perpetual license to practice any inventions made or conceived solely by SAFC and incorporated into the
manufacturing or packaging processes associated with the Product.
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| | 3.3 |  | Limitation on Use: Except as expressly stated in this Agreement, no Intellectual Property rights of any kind or nature are conveyed by this Agreement and neither Party shall have
any right, title or interest in or to the other Partys Intellectual Property rights for any purpose whatsoever without such other Partys prior written consent. Upon termination of this Agreement for whatever reason, neither Party shall
use or exploit in any manner whatsoever any Intellectual Property rights or nature belonging solely to the other Party.
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ARTICLE 4

EQUIPMENT PRICE



|4. |  | The Parties agree to the following provisions regarding equipment price:
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| | 4.1 |  | Client shall pay for the price of equipment specifically purchased for the processing of Product including the price for purchasing and installing the equipment, as well as any and
all maintenance costs associated with such equipment subject to Clients prior approval of such prices, which shall not be unreasonably withheld. Currently, SAFC is in possession of certain pectin dispensing equipment at its manufacturing site
which is owned by and utilized solely for the benefit of Client for the processing of the Product herein.
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| | 4.2 |  | Client shall own equipment paid for by Client pursuant to Section 4.1. Client shall have the right to file such UCC filings as necessary to establish ownership of such equipment.
SAFC may purchase such equipment at the termination of this Agreement at the fair market value of such equipment at that time as mutually agreed by the Parties.
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| | 4.3 |  | Any price associated with the removal of equipment and to return the facility in serviceable condition shall be borne by Client.
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ARTICLE 5

REPRESENTATIONS AND WARRANTIES



|5. |  | The Parties agree to the following representations and warranties:
|-- |  | ------------------------------------------------------------------



| | 5.1 |  | The Parties represent and warrant to the other as follows:
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| | 5.1.1 |  | It has full power and authority to enter into this Agreement and consummate the transactions contemplated hereby and that the terms of this Agreement are not inconsistent with other
contractual obligations, expressed or implied, by which it is bound.
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| | 5.1.2 |  | It has such permits, licenses, and authorizations of government or regulatory authorities as are necessary to own its respective properties, conduct its business and consummate the
transactions contemplated hereby, provided however, that Client shall be solely responsible for obtaining all permits, licenses, and authorizations for SAFC to process and ship Product(s), except for securing approval of SAFCs facility as a
registered FDA facility, which shall be the responsibility of SAFC.
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| | 5.1.3 |  | It is not currently under investigation for disbarment action, debarred, suspended, or otherwise excluded by the FDA or other Regulatory Authority from conducting business.
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| | 5.1.4 |  | All laboratory, scientific, technical and/or other data submitted by or on behalf of Client or SAFC, as the case may be, relating to Product(s) shall, to the best of their
knowledge, be true and correct and shall not contain any material falsification, misrepresentation or omission.
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| | 5.2 |  | SAFC represents and warrants to Client as follows:
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| | 5.2.1 |  | Product(s) shall be processed in compliance with the Quality Agreement and all applicable laws.
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| | 5.2.2 |  | Product(s), as processed and delivered, shall comply with specifications and shall not be adulterated or misbranded within the meaning of the Act or other substantially similar laws
and statutes, provided however that the foregoing shall not apply to the extent that any such breach is caused by any materials provided by Client or due to compliance with any specifications or instructions provided by Client.
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| | 5.2.3 |  | The manufacturing facilities for Product(s) shall conform, and will throughout the term of this Agreement, in all respects to applicable laws, regulations, and approvals governing
such facility, including, but not limited to, the cGMPs as defined by 21 Code of Federal Regulation Sections 210, 211, et seq., and will be adequate to produce the quantities of Product(s) as detailed in the Project Charter(s). SAFC
shall implement such requirements as may be necessary to comply with The Control of Substance Hazardous to Health (COSHH) Regulations of 1988, consolidated in 1994, amended in 1996, 1997 and 1998 and further consolidated in 1999 in connection with
the performance of its obligations under this Agreement.
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| | 5.2.4 |  | Neither it nor any person employed by it or to be employed by it to perform the Project Charter(s) (i) is presently under any obligation which conflicts with their duties
contemplated hereunder and agrees not to undertake any project which will conflict with these duties during the conduct of the Project Charter(s) or (ii) has a disqualification hearing pending or has been disqualified by the FDA pursuant to 21
C.F.R. Section 312.70 or the European Union equivalent. In the event any of the foregoing occurs, SAFC shall immediately notify Client.
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| | 5.3 |  | Client represents and warrants to SAFC as follows:
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| | 5.3.1 |  | Client has the full power and authority to grant the license it grants under this Agreement and neither the granting of such license nor the exercise by SAFC of the rights granted
by Client under such license breaches any obligation to or right of any Third Party.
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| | 5.3.2 |  | Neither the Clients Product technology, nor the use thereof by SAFC, shall infringe, violate nor misappropriate any patent, copyright, trademark, trade secret or other
intellectual property of any Third Party.
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| | 5.3.3 |  | Any excipients, APIs or other materials provided by Client to SAFC shall comply with specifications and shall not be adulterated or misbranded within the meaning of the Act or
other substantially similar laws and statutes.
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| | 5.3.4 |  | Client will disclose to SAFC any information currently known or learned subsequent to the execution of this Agreement regarding toxicity, or other known health or environmental
hazards or other safe handling requirements for the API or Product(s) as the case may be.
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| | 5.4 |  | THE WARRANTIES SET FORTH HEREIN ARE THE SOLE AND EXCLUSIVE WARRANTIES MADE BY EITHER PARTY UNDER THIS AGREEMENT, AND NEITHER PARTY MAKES ANY OTHER WARRANTIES EXPRESS OR IMPLIED OR
ARISING BY LAW, INCLUDING, BUT NOT LIMITED TO, ANY IMPLIED WARRANTY ARISING FROM THE COURSE OF PERFORMANCE, COURSE OF DEALING OR USAGE OF TRADE.
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| | 5.5 |  | EXCEPT FOR THE INDEMNITY OBLIGATIONS SET FORTH IN THIS AGREEMENT AND IN THE EVENT OF A BREACH OF THE CONFIDENTIALITY OBLIGATIONS SET FORTH IN THIS AGREEMENT, UNDER NO CIRCUMSTANCES
WILL EITHER PARTY BE LIABLE TO THE OTHER UNDER ANY CONTRACT, TORT, STRICT LIABILITY, NEGLIGENCE OR OTHER LEGAL OR EQUITABLE THEORY, FOR COVER OF ANY INDIRECT, INCIDENTAL OR CONSEQUENTIAL DAMAGES OR LOST PROFITS IN CONNECTION WITH THE SUBJECT MATTER
OF THIS AGREEMENT INCLUDING WITHOUT LIMITATION THE PRODUCT(S) OR ANY SERVICES PROVIDED IN CONNECTION WITH THE PRODUCT(S) EXCEPT FOR THE INDEMNITY OBLIGATIONS SET FORTH IN THIS AGREEMENT.
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ARTICLE 6

NONCONFORMING PRODUCT



|6. |  | In the event of Client finding the quality of Product(s) is/are not acceptable in terms of Specifications, Client shall have thirty (30) calendar days from the date of its receipt
of the Product(s) to notify SAFC, specifying the respects in which the Product(s) is/are not acceptable. In the event that SAFC shall dispute any such determination by Client, the Parties shall use their best efforts to resolve the dispute amicably.
If the Parties are unable to do so, the matter shall be referred to an independent laboratory or consultant, mutually agreed to by both Parties, whos decision shall be final and binding. The Party against whom the dispute is decided shall pay
for any charges for such laboratory or consultant. SAFCs liability will be limited to replacement of the Product provided Client.
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ARTICLE 7

PRICE  PAYMENT



|7. |  | The Parties agree to the following price and payment provisions:
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| | 7.1 |  | The price to be paid by Client for the Project Charter shall be defined in the Project Charter Documents as such may be amended to this Agreement from time to time.
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| | 7.2 |  | SAFC shall submit invoices to Client reflecting the work completed in accordance with the applicable milestones described in the applicable Project Charter documents. The invoices
shall be sent to the following address:
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| |  | GlycoGenesys, Inc., Attention: Accounts
Payable 31 St. James Avenue Boston, Massachusetts
02116 |  | 
| |  | ----------------------------------------------------------------------------------------------- |  | 



| | 7.3 |  | All payments due hereunder to SAFC shall be sent to SAFC by wire transfer of funds via the Federal Reserve Wire Transfer System to:
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| |  | Sigma-Aldrich, Inc. C/O Wachovia Bank,
N.A. P.O. Box 932594 Atlanta, GA 31193-2594 Account # ABA# |  | 
| |  | ------------------------------------------------------------------------------------------------- |  | 



Client shall make any and all payments in accordance with the Project Charter described in Exhibit A hereto.



| | 7.4 |  | All prices for Product shall be on the basis of Product being shipped F.O.B. St. Louis, Missouri to Clients plant in Spokane, Washington, under Freight Collect
terms. Shipment of Product(s) shall be arranged by Client, and the price and liability of such shipment borne by Client.
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ARTICLE 8

CONFIDENTIALITY



|8. |  | In carrying out Project Charter(s) it is recognized by SAFC and Client that each may have to disclose to the other Confidential Information. Since both Parties wish to assume that
Confidential Information is properly protected they hereby agree as follows:
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| | 8.1 |  | Form of Disclosure: Confidential Information may be disclosed in either oral, written or electronic form.
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| | . |  | The receiving Partys duties under this Agreement shall apply only to Confidential Information that is: (a) disclosed by the
disclosing Party in writing and marked to indicate it is confidential at the time of disclosure; or (b) disclosed by the disclosing Party in any other manner and indicated to be confidential at the time of disclosure and thereafter is summarized in
a written memorandum, marked to indicate it is confidential and delivered to receiving Party within thirty (30) days of disclosure; or (c) disclosed in the form of tangible products or materials transmitted to the receiving Party with an
accompanying written memorandum.
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| | 8.2 |  | Obligations: The receiving Party agrees to hold Confidential Information in strict confidence and to use it only for the purposes under this Agreement. The receiving Party agrees
not to disclose the Confidential Information to any Third Party unless prior written authorization has been obtained from the disclosing Party. These obligations shall not apply to:
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| | 8.2.1 |  | Information which, at the time of disclosure, is in the public domain.
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| | 8.2.2 |  | Information which, after disclosure, becomes part of the public domain by publication or otherwise, except by breach of this Agreement by the receiving Party.
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| | 8.2.3 |  | Information which the receiving Party can demonstrate by its written records was in the receiving Partys possession at the time of the disclosure, and which was not acquired
directly or indirectly, from the disclosing Party.
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| | 8.2.4 |  | Information which is lawfully disclosed to the receiving Party on a non-confidential basis by a Third Party who is not obligated to the disclosing Party or any other Third Party to
retain such information in confidence.
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| | 8.2.5 |  | Information which results from research and development by the receiving Party independent of such disclosure as shown by competent evidence.
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| | 8.2.6 |  | Information which is required to be disclosed by legal process, but only that portion of Information which is legally required to be disclosed; provided, in each case the Party so
required to disclose such Information informs the other Party as promptly as practicable in order to enable the other Party to seek a protective order or other appropriate remedy. The Party required to disclose such Information shall use its best
efforts to limit the disclosure and maintain confidentiality to the extent possible. The Party required to disclose such Information shall give the other Party written notice of any Confidential Information disclosed pursuant to this Section 8.2.6.
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| | 8.3 |  | Both Parties covenant and agree that they have and shall maintain an appropriate internal program limiting the internal distribution of Confidential Information to those of its
Affiliates, subsidiaries, officers, servants, or agents who require said Confidential Information so that either Party may use Confidential Information for the purpose set forth in this Agreement. The Parties may disclose each others
Confidential Information to third-party consultants but only to the extent that they require access to Confidential Information in order to enable each other to carry out the purpose of this Agreement. The Parties covenant and agree that before
making any Confidential Information available to said Affiliates, subsidiaries, officers, servants, agents, or third-party consultants, they shall inform such parties of the confidential nature of such information and obtain their agreement to be
bound by obligations of confidentiality and non-use which are equivalent to or greater than those set forth in this Agreement. The receiving Party agrees to promptly notify the disclosing Party in writing if it becomes aware of a breach of this
Article 8 by it or any party to whom it disclosed Confidential Information pursuant to this Section 8.3.
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| | 8.4 |  | The receiving Party hereby acknowledges that disclosure or use of Confidential Information may result in irreparable harm to the disclosing Party. Accordingly, the receiving Party
agrees that the disclosing Party shall have the right to seek equitable relief, including without limitation an injunction or temporary restraining order, in the event of any actual or threatened breach of this Article 8.
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| | 8.5 |  | Upon the written request of the disclosing Party, Confidential Information in tangible or electronic form received by the receiving Party from the disclosing Party shall, at the
disclosing Partys sole option and expenses either be destroyed or immediately returned and the receiving Party shall provide written certification that all copies of Confidential Information have been destroyed or returned; provided, however
the receiving Party may maintain a single copy of the Confidential Information and its work product containing Confidential Information solely for the purposes of monitoring or demonstrating its compliance with this Agreement or applicable laws or
regulations.
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| | 8.6 |  | The obligations and duties of nondisclosure under Article 8 shall survive the termination or expiration of this Agreement for a period of five (5) years thereafter.
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ARTICLE 9

INDEMNIFICATION



|9. |  | The Parties agree to the following Indemnification clauses:
|-- |  | -----------------------------------------------------------



| | 9.1 |  | Indemnification by Client: Client shall indemnify, defend and hold SAFC, its Affiliates and their respective directors, officers, employees, agents, successors and assigns harmless
from and against any damages, judgements, claims, suits, actions, liabilities, costs and expenses (including, but not limited to, reasonable attorneys fees) resulting from any Third Party claims or suits arising solely out of (1) the use,
handling, distribution, marketing or sale of the Product(s) except to the extent caused by SAFCs negligent acts or omissions or willful misconduct in its performance of the Project Charter(s) or the manufacture or bulk packaging of the
Product(s), (2) Clients uncured material breach of any of its warranties or representations hereunder, or (3) Clients grossly negligent acts or omissions or willful misconduct.
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| | 9.2 |  | Indemnification by SAFC: Except as otherwise provided in Section 9.1 above, SAFC shall indemnify, defend and hold Client, its Affiliates and their respective directors, officers,
employees, agents, successors and assigns harmless from and against any damages, judgements, claims, suits, actions, liabilities, costs and expenses (including, but not limited to, reasonable attorneys fees) resulting from any Third Party
claims or suits arising solely out of (1) SAFCs material breach of any of its warranties or representations hereunder or (2) SAFCs grossly negligent acts or omissions or willful misconduct in its performance of the Project Charter(s) or
the manufacture or bulk packaging of the Intermediate(s) and Product(s).
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| | 9.3 |  | Indemnification Procedures:
| | --- |  | ---------------------------



| | 9.3.1 |  | Any Party hereto seeking indemnification hereunder (in this context the Indemnified Party) shall notify the other Party (in this context the Indemnifying
Party) in writing reasonably promptly after the assertion against the Indemnified Party any claim or suit by a Third Party (a Third Party Claim) in respect of which the Indemnified Party intends to base a claim for indemnification
hereunder.
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| | 9.3.2 |  | (1) The Indemnifying Party shall have the right, upon written notice given to the Indemnified Party within thirty (30) calendar days after receipt of the notice from the Indemnified
Party of any Third Party Claim, to assume the defense and handling of such Third Party Claim, at the Indemnifying Partys sole expense, in which case the provisions of Section 9.3.2 (2) below shall govern. (2) The Indemnifying Party shall
select counsel reasonably acceptable to the Indemnified Party in connection with conducting the defense and handling of such Third Party Claim, and the Indemnifying Party shall defend or handle the same in consultation with the Indemnified Party,
and shall keep the Indemnified Party appraised of the status of the Third Party Claim. The Indemnifying Party shall not, without the prior written consent of the Indemnified Party, which consent will not be unreasonably withheld, agree to a
settlement of any Third Party Claim that could directly or indirectly lead to liability or create any financial or other obligation on the part of the Indemnified Party for which the Indemnified Party is not entitled to indemnification hereunder.
The Indemnified Party shall cooperate with the Indemnifying Party and shall be entitled to participate in the defense or handling of such Third Party Claim with its own counsel at its own expense.
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| | 9.3.3 |  | (1) If the Indemnifying Party does not give written notice to the Indemnified Party, within thirty (30) calendar days after receipt of the notice from the Indemnified Party of any
Third Party Claim, of the Indemnifying Partys election to assume the defense or handling of such Third Party Claim, the provisions of Section 9.3.3 (2) below shall govern. (2) The Indemnified Party may, at the Indemnifying Partys
expense, select counsel in connection with conducting the defense or handling of such Third Party Claim and defend or handle such Third Party Claim in such manner as it may deem appropriate, provided, however, that the Indemnified Party shall keep
the Indemnifying Party timely appraised of the status of such Third Party Claim and shall not settle such Third Party Claim without the prior written consent of the Indemnifying Party, which consent shall not be unreasonably withheld. If the
Indemnified Party defends or handles such Third Party Claim, the Indemnifying Party shall cooperate with the Indemnified Party and shall be entitled to participate in the defense or handling of such Third Party Claim with its own counsel and at its
own expense.
| | ----- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 9.3.4 |  | If the Indemnified Party intends to seek indemnification hereunder, other than for a Third Party Claim, then it shall notify the Indemnifying Party in writing within three (3)
months after its discovery of facts upon which it intends to base its Claim for indemnification hereunder; provided, however, the failure to timely give such notice shall limit the Indemnifying Partys liability for indemnification only to the
extent the Indemnifying Partys defense of such matter has been prejudiced.
| | ----- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 9.3.5 |  | Except with regard to fraud or pursuant to Section 8.4, the indemnification remedies in this Article 9, enforced in accordance with Section 9.3, shall constitute the sole and
exclusive remedies of the Parties with respect to any matters arising under or relating to this Agreement.
| | ----- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 9.4 |  | Survival of Indemnification Obligations: The provisions of this Article 9 shall survive the expiration or termination of this Agreement for a period of five (5) years.
| | --- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 9.5 |  | Limitation of Liability and Claims: Neither Party shall be liable to the other Party for indirect, special, punitive, or consequential damages of any kind, including without
limitation lost profits or loss of good will or otherwise. Neither Partys liability to the other under this Agreement shall exceed Five Million Dollars ($5,000,000).
| | --- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 9.6 |  | Insurance: Both Client and SAFC shall obtain and maintain, either itself or through one or more of its affiliates, with reputable carriers, product liability insurance with limits
of not less than Five Million Dollars ($5,000,000) per claim/annual aggregate by no later than the scheduled manufacturing date for the first Batch of Product(s) delivered as part of the first Project Charter(s) conducted under this Agreement. In
addition, SAFC shall maintain commercial general liability insurance including premises and operations coverage of not less than $1,000,000 per occurrence and $2,000,000 per accident and will endeavor to provide property damages liability insurance
of not less than $1,000,000 per occurrence and $1,000,000 per accident. Each Party hereto shall have its insurance carrier(s) furnish the other Party hereto with a certificate that such insurance is in force. In the event of any proposed
cancellation, non-renewal, or material adverse change in such coverage, the other Party hereto shall be given at least thirty (30) calendar days advance written notice thereof.
| | --- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



ARTICLE 10

TERM AND TERMINATION



|10. |  | The Parties agree to the following Term and Termination clauses:
|--- |  | ----------------------------------------------------------------



| | 10.1 |  | Term: This Agreement shall remain in full force and effect for a period of six (6) months from the Effective Date herein or as otherwise agreed to by the parties in writing.
| | ---- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 10.2 |  | Termination by Mutual Agreement: This Agreement may be terminated, at any time upon mutual written agreement between the Parties.
| | ---- |  | ---------------------------------------------------------------------------------------------------------------------------------





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| | 10.3 |  | Termination for Default: This Agreement may be terminated by either Party in the event of material breach or default by the other Party of the terms and conditions hereof; provided,
however, the other Party shall first give to the defaulting Party written notice of the proposed termination or cancellation of this Agreement, specifying the grounds therefor. Upon receipt of such notice, with respect to such defaults as are
capable of being cured, the defaulting Party shall have forty-five (45) calendar days to respond by curing such default. If the breaching Party does not respond or fails to work diligently to cure such breach within the additional time set forth
above, then the other Party may either suspend the Agreement indefinitely or terminate the Agreement. Termination of this Agreement pursuant to this Section 10.3 shall not affect any other rights or remedies which may be available to the
nondefaulting Party.
| | ---- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 10.4 |  | Bankruptcy; Insolvency:
| | ---- |  | -----------------------



| | 10.4.1 |  | Either Party may terminate this Agreement upon the occurrence of any of the following with respect to the other Party:
| | ------ |  | ----------------------------------------------------------------------------------------------------------------------



| | 10.4.1.1 |  | The entry of a decree or order for the relief by a court having jurisdiction in the premises in respect of such other Party in an Involuntary case under the Federal Bankruptcy Code,
as now constituted or hereafter amended, or any other applicable federal or state insolvency or other similar law and the continuance of any such decree or order unstayed and in effect for a period of sixty (60) consecutive calendar days;
| | -------- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 10.4.1.2 |  | The filing of such other Party of a petition for relief under the Federal Bankruptcy Code, as now constituted or hereafter amended, or by any other applicable federal or state
insolvency or other similar law, or;
| | -------- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 10.4.1.3 |  | The failure of such other Party to pay its debts when due.
| | -------- |  | ----------------------------------------------------------



| | 10.4.2 |  | SAFC shall notify Client of its intent to file for protection under the Federal Bankruptcy Code as soon as such a determination is made. SAFC will segregate all Client-related
documents, including, but not limited to, manufacturing and analytical equipment protocols, qualifications, procedures, methods, calibrations reports and/or certificates, Specifications, Manufacturing Procedures, Intermediate and Product analytical
data, SAFC facility documentation in support of Project Charters; all Client provided manufacturing and analytical testing equipment, including any equipment purchased by Client for SAFC in conjunction with the Project Charter; all unconsumed raw
materials provided by Client to SAFC in conjunction with the Project Charter; and all Product Batches, that were produced in accordance with the Project Charter. SAFC will provide Client complete and total access to these materials at Clients
request.
| | ------ |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 10.5 |  | Rights and Duties Upon Termination:
| | ---- |  | -----------------------------------



| | 10.5.1 |  | Upon termination of this Agreement, SAFC shall, promptly as practicable, cease work on the Project Charter and turn over to Client one (1) copy of all results, documentation and
information obtained during the Project Charter (whether in written or electronic form) and all Product Batches, as well as all unconsumed raw materials provided by Client which are then in SAFCs possession and which are the property of Client
in accordance with this Agreement.
| | ------ |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 10.5.2 |  | Upon termination of this Agreement, Client shall remain liable for all fees, expenses, and uncancellable obligations incurred hereunder through the date of such termination.
| | ------ |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------





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ARTICLE 11

FORCE MAJEURE/DISPUTE RESOLUTION



|11. |  | The Parties agree to the following Force Majeure/Dispute Resolution clauses:
|--- |  | ----------------------------------------------------------------------------



| | 11.1 |  | Effect of Force Majeure: Neither Party shall be held liable or responsible for any loss or damages resulting from any failure or delay in its performance due hereunder (other than
payment of money) caused by force majeure. As used herein, force majeure shall be deemed to include any condition beyond the reasonable control of the affected Party including, without limitation, war, riot, earthquake, tornado, hurricane, flood or
other natural disasters, fire, civil disorder, explosion, accident, sabotage, lack of or inability to obtain adequate fuel, power, materials, labor, containers, transportation, supplies or equipment, compliance with governmental requests, laws,
rules, regulations, orders or actions; inability despite best efforts to renew operating permits or licenses from local, state or federal governmental authorities; breakage or failure of machinery or apparatus; national defense requirements; or
supplier strike, lockout or injunction. SAFC shall notify Client of any foreseeable force majeure events, including, but not limited to, shipping interruptions or problems, and inability to procure supplies necessary for SAFC to perform any of its
obligations under this Agreement.
| | ---- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 11.2 |  | Notice of Force Majeure: In the event either Party is delayed or rendered unable to perform due to force majeure, the affected Party shall give notice of the same and its expected
duration to the other Party promptly after the occurrence of the cause relied upon, and upon the giving of such notice the obligations of the Party giving the notice will be suspended during the continuance of the force majeure; provided, however,
such Party shall take commercially reasonable steps to remedy or mitigate the force majeure with all reasonable dispatch.
| | ---- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 11.3 |  | Dispute Resolution: The Parties hereto agree to perform the terms of this Agreement in good faith, and to attempt to resolve any controversy, dispute or claim arising hereunder in
good faith. Any dispute regarding the validity, construction, interpretation, or performance of this Agreement (other than provisions, hereof relating to any intellectual property rights, or the confidentiality obligations contained in Article 8
hereof) shall be (1) first attempted to be resolved between the CEO/President of each Party and failing that (2) submitted to binding arbitration in Seattle, Washington, U.S.A. to be conducted in accordance with the Arbitration Rules of the American
Arbitration Association (AAA); provided, however, that nothing in this Section 11.3 shall be construed to preclude either Party from seeking provisional remedies, including, but not limited to, temporary restraining orders and
preliminary injunctions, from any court of competent jurisdiction, in order to protect its rights pending arbitration, but such preliminary relief shall not be sought as a means of avoiding arbitration. Any arbitration hereunder shall be submitted
to an arbitration tribunal made up of three (3) members, one of whom shall be selected by Client, one of whom shall be selected by SAFC, and one of whom shall be selected by the other two arbitrators. All arbitration proceedings shall be conducted
in English. The order or award of the arbitrators shall be final and may be enforced in any court of competent jurisdiction. The prevailing Party in any legal or arbitration action brought by one Party against the other Party shall be entitled, in
addition to any other rights and remedies it may have, to reimbursement for its expenses incurred thereby, including court cost and reasonable attorneys fees. The Parties shall have the right of limited prehearing discovery, including:
| | ---- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 11.3.1 |  | exchange of witness lists;
| | ------ |  | --------------------------



| | 11.3.2 |  | exchange of documentary evidence and reasonably related documents;
| | ------ |  | ------------------------------------------------------------------



| | 11.3.3 |  | written interrogations; and
| | ------ |  | ---------------------------



| | 11.3.4 |  | subject to reasonable discretion of the arbitrators and upon good cause shown dispositions under oath of any witnesses who are to be called to testify at the arbitration hearing.
| | ------ |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 11.4 |  | As soon as the discovery is concluded, the arbitrators shall hold a hearing in accordance with the aforesaid AAA rules.
| | ---- |  | -----------------------------------------------------------------------------------------------------------------------



12



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ARTICLE 12

NOTICES



|12. |  | All notices provided herein shall be in writing and shall be deemed to be delivered when deposited in the United States mail, postage prepaid, or hand-delivered to an authorized
representative of the Party to whom notice is directed, or sent by facsimile, or express service courier, charges prepaid, to the address of the other Party designated below:
|--- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|Client  GlycoGenesys, Inc. 31 St. James
Avenue Boston, MA 02116 Attention: Mark Staples FAX: (617) 422-0675 |  | SAFC  Sigma-Aldrich Fine Chemicals, a division of
Sigma-Aldrich, Inc. 3050 Spruce Street, St. Louis, Missouri 63103 Attention: Paula L. Rehkemper Fax: 314-286-8005
|----------------------------------------------------------------------------------------------------------- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------



The addresses and
persons provided above may be changed by either Party by providing the other Party with written notice of such change.



ARTICLE 13

MISCELLANEOUS



|13. |  | The Parties agree to the following Miscellaneous clauses:
|--- |  | ---------------------------------------------------------



| | 13.1 |  | Entire Agreement: This Agreement, attachments and exhibits contain the entire understanding between the Parties with respect to the subject matter hereof, and may be modified, only
by a written instrument duly executed by each Partys authorized representative.
| | ---- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 13.2 |  | Independent Contractor: Nothing herein shall create any equity association, partnership, joint venture, or ownership relation of principal and agent between the parties hereto, it
being understood that Client is purchasing SAFC services as an independent company, and neither Party shall have the authority to bind the other party or the others representatives in any way.
| | ---- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 13.3 |  | Publicity: Except as explicitly set forth below in Section 13.4, any press release, publicity or other form of public written disclosure related to this Agreement prepared by one
Party shall be submitted to the other party prior to release for written approval, which approval shall not be unreasonably withheld or delayed by such other Party.
| | ---- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 13.4 |  | Use of Partys Name: Except as expressly provided or contemplated hereunder and except as otherwise required by applicable law, no right is granted pursuant to this Agreement
to either Party to use in any manner the trademarks or name of the other Party, or any other trade name, service mark, or trademark owned by or licensed to the other Party in connection with the performance of the Agreement. To the extent required
by applicable law, the Parties shall be permitted to use the other Partys name and disclose the existence and terms of this Agreement in connection with required public regulatory fillings, public securities filings and private placement
memoranda and documentation, using reasonable commercial efforts to protect the confidentiality of the terms of this Agreement.
| | ---- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------





13



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| | 13.5 |  | Severability: Each Party hereby expressly agrees that it has no intention to violate any public policy, statutory or common laws, rules, regulations, treaty or decision of any
government agency or executive body of any country or community or association of countries; that if any word, sentence, paragraph, clause or combination thereof in this Agreement is found by a court or executive body with judicial powers having
jurisdiction other this Agreement or either Party hereto, in a final unappealed order, to be in violation of any such provisions in any country or community or association of countries, such words, sentences, paragraphs, clauses or combination shall
be inoperative in such country or community or association of countries and the remainder of this Agreement shall remain binding upon the Parties, so long as enforcement of the remainder does not violate the Parties overall intentions in this
transaction.
| | ---- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 13.6 |  | Assignment; Subcontractors: This Agreement may not be assigned or otherwise transferred by either Party without the prior written consent of the other Party; provided, however,
either Party may, without such consent, assign this Agreement.
| | ---- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 13.6.1 |  | in connection with the transfer or sale of all or substantially all of the assets or voting securities of such Party or the line of business of which this Agreement forms a part,
| | ------ |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 13.6.2 |  | in the event of a merger or consolidation of a Party hereto with another company or to any Affiliate of the assigning Party fully capable of performing hereunder.
| | ------ |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------



Any purported assignment in violation of the
proceeding shall be void. Any permitted assignee shall assume all obligations of its assignor under this Agreement. No assignment shall relieve either Party of responsibility for the performance of any obligation which accrued prior to the effective
date of such assignment.



| | 13.7 |  | Governing Law: This Agreement shall be governed by and construed in accordance with the laws of the state of Missouri, irrespective of any conflicts of law rule which may direct or
refer such determination of applicable law to any other state; and if this Agreement were performed wholly within the state of Missouri.
| | ---- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 13.8 |  | Headings: Paragraph headings and captions used herein are for convenience of reference only and shall not be used in the construction or interpretation of this Agreement.
| | ---- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 13.9 |  | Continuing Obligations: Termination, assignment or expiration of this Agreement shall not relieve either Party from full performance of any obligations incurred prior thereto.
| | ---- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 13.10 |  | Waiver: Neither Partys waiver of any breach or failure to enforce any of the terms and conditions of this Agreement, at any time, shall not in any way affect, limit or waive
such Partys right thereafter to enforce and compel strict compliance with every term and condition of this Agreement.
| | ----- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 13.11 |  | Construction: This Agreement has been jointly prepared on the basis of the mutual understanding of the Parties and shall not be construed against either Party by reason of such
Partys being the drafter hereof or thereof.
| | ----- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 13.12 |  | Exhibits, Schedules and Attachments: Any and all exhibits, schedules and attachments referred to herein form an integral part of this Agreement and are incorporated into this
Agreement by such reference.
| | ----- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | 13.13 |  | Specially Regulated Waste: The prices associated with the removal of Specially Regulated Waste shall be borne by Client. Client will be notified of the determination of Specially
Regulated Waste and advised of the price for destruction of said waste.
| | ----- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



14



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IN WITNESS WHEREOF, this Agreement has been executed by the Parties as of the day and year first written above.



|FOR: SAFC                  |  | FOR: GLYCOGENESYS, INC.                
|-------------------------- |  | ---------------------------------------
|                           | 
|/s/ David FeldkerSignature |  | /s/ Mark StaplesSignature              
|                           | 
|David FeldkerPrinted Name  |  | Mark A. Staples, MBA, Ph.D.Printed Name
|                           | 
|Vice PresidentTitle        |  | VP Development and ManufacturingTitle  
|                           | 
|Aug. 22, 2003Date Signed   |  | Aug. 21, 2003Date Signed               



15