Exhibit 10.3


  


EDGEWISE THERAPEUTICS, INC.


 


2021 EQUITY INCENTIVE PLAN


 


		1.	Purposes of the Plan.
The purposes of this Plan are:



 


		•	to attract and retain the best available personnel for positions of substantial responsibility,



 


		•	to provide additional incentive to Employees, Directors and Consultants, and



 


		•	to promote the success of the Company’s business.



 


The Plan permits the
grant of Incentive Stock Options, Nonstatutory Stock Options, Stock Appreciation Rights, Restricted Stock, Restricted Stock Units
and Performance Awards.


 


		2.	Definitions. As
used herein, the following definitions will apply:



 


2.1          “Administrator”
means the Board or any of its Committees as will be administering the Plan, in accordance with Section 4 of the Plan.


 


2.2          “Applicable
Laws” means the legal and regulatory requirements relating to the administration of equity-based awards, including but
not limited to the related issuance of shares of Common Stock, including but not limited to, under U.S. federal and state corporate
laws, U.S. federal and state securities laws, the Code, any stock exchange or quotation system on which the Common Stock is listed
or quoted and the applicable laws of any non-U.S. country or jurisdiction where Awards are, or will be, granted under the Plan.


 


2.3         “Award”
means, individually or collectively, a grant under the Plan of Options, Stock Appreciation Rights, Restricted Stock, Restricted
Stock Units, or Performance Awards.


 


2.4           “Award
Agreement” means the written or electronic agreement setting forth the terms and provisions applicable to each Award
granted under the Plan. The Award Agreement is subject to the terms and conditions of the Plan.


 


2.5           “Board”
means the Board of Directors of the Company.


 


2.6           “Change
in Control” means the occurrence of any of the following events:


 






     


     


    

 


(a)           Change
in Ownership of the Company. A change in the ownership of the Company which occurs on the date that any one person, or more
than one person acting as a group (“Person”), acquires ownership of the stock of the Company that, together
with the stock held by such Person, constitutes more than fifty percent (50%) of the total voting power of the stock of the
Company; provided, however, that for purposes of this subsection (a), the acquisition of additional stock by any one Person,
who is considered to own more than fifty percent (50%) of the total voting power of the stock of the Company will not be considered
a Change in Control; provided, further, that any change in the ownership of the stock of the Company as a result of a private financing
of the Company that is approved by the Board also will not be considered a Change in Control. Further, if the stockholders of the
Company immediately before such change in ownership continue to retain immediately after the change in ownership, in substantially
the same proportions as their ownership of shares of the Company’s voting stock immediately prior to the change in ownership,
direct or indirect beneficial ownership of fifty percent (50%) or more of the total voting power of the stock of the Company or
of the ultimate parent entity of the Company, such event will not be considered a Change in Control under this subsection (a).
For this purpose, indirect beneficial ownership will include, without limitation, an interest resulting from ownership of the voting
securities of one or more corporations or other business entities which own the Company, as the case may be, either directly or
through one or more subsidiary corporations or other business entities; or


 


(b)           Change
in Effective Control of the Company. If the Company has a class of securities registered pursuant to Section 12 of the
Exchange Act, a change in the effective control of the Company which occurs on the date that a majority of members of the Board
is replaced during any twelve (12) month period by Directors whose appointment or election is not endorsed by a majority of the
members of the Board prior to the date of the appointment or election. For purposes of this subsection (b), if any Person is considered
to be in effective control of the Company, the acquisition of additional control of the Company by the same Person will not be
considered a Change in Control; or


 


(c)          Change
in Ownership of a Substantial Portion of the Company’s Assets. A change in the ownership of a substantial portion of
the Company’s assets which occurs on the date that any Person acquires (or has acquired during the twelve (12) month
period ending on the date of the most recent acquisition by such Person or Persons) assets from the Company that have a total
gross fair market value equal to or more than fifty percent (50%) of the total gross fair market value of all of the assets
of the Company immediately prior to such acquisition or acquisitions; provided, however, that for purposes of this subsection (c),
the following will not constitute a change in the ownership of a substantial portion of the Company’s assets: (i) a
transfer to an entity that is controlled by the Company’s stockholders immediately after the transfer, or (ii) a transfer
of assets by the Company to: (A) a stockholder of the Company (immediately before the asset transfer) in exchange for
or with respect to the Company’s stock, (B) an entity, fifty percent (50%) or more of the total value or voting
power of which is owned, directly or indirectly, by the Company, (C) a Person, that owns, directly or indirectly, fifty percent
(50%) or more of the total value or voting power of all the outstanding stock of the Company, or (D) an entity, at least
fifty percent (50%) of the total value or voting power of which is owned, directly or indirectly, by a Person described in
this subsection (c)(ii)(C). For purposes of this subsection (c), gross fair market value means the value of the assets of the Company,
or the value of the assets being disposed of, determined without regard to any liabilities associated with such assets.


 


For purposes of this
Section 2.6, persons will be considered to be acting as a group if they are owners of a corporation that enters into a merger,
consolidation, purchase or acquisition of stock, or similar business transaction with the Company.


 






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Notwithstanding the
foregoing, a transaction will not be deemed a Change in Control unless the transaction qualifies as a change in control event
within the meaning of Code Section 409A.


 


Further and for the
avoidance of doubt, a transaction will not constitute a Change in Control if: (x) its sole purpose is to change the jurisdiction
of the Company’s incorporation, or (y) its sole purpose is to create a holding company that will be owned in substantially
the same proportions by the persons who held the Company’s securities immediately before such transaction.


 


2.7         “Code”
means the U.S. Internal Revenue Code of 1986, as amended. Reference to a specific section of the Code or regulation thereunder
will include such section or regulation, any valid regulation or other formal guidance of general or direct applicability promulgated
under such section, and any comparable provision of any future legislation or regulation amending, supplementing or superseding
such section or regulation.


 


2.8         “Committee”
means a committee of Directors or of other individuals satisfying Applicable Laws appointed by the Board, or by a duly authorized
committee of the Board, in accordance with Section 4 hereof.


 


2.9          “Common
Stock” means the common stock of the Company.


 


2.10        “Company”
means Edgewise Therapeutics, Inc., a Delaware corporation, or any successor thereto.


 


2.11        “Consultant”
means any natural person, including an advisor, engaged by the Company or any of its Parent or Subsidiaries to render bona fide
services to such entity, provided the services (a) are not in connection with the offer or sale of securities in a capital-raising
transaction, and (b) do not directly promote or maintain a market for the Company’s securities, in each case, within
the meaning of Form S-8 promulgated under the Securities Act, and provided further, that a Consultant will include only those
persons to whom the issuance of Shares may be registered under Form S-8 promulgated under the Securities Act.


 


2.12       “Director”
means a member of the Board.


 


2.13        “Disability”
means total and permanent disability as defined in Code Section 22(e)(3), provided that in the case of Awards other than Incentive
Stock Options, the Administrator in its discretion may determine whether a permanent and total disability exists in accordance
with uniform and non-discriminatory standards adopted by the Administrator from time to time.


 


2.14       “Employee”
means any person, including Officers and Directors, employed by the Company or any Parent or Subsidiary of the Company. Neither
service as a Director nor payment of a director’s fee by the Company will be sufficient to constitute “employment”
by the Company.


 


2.15       “Exchange
Act” means the U.S. Securities Exchange Act of 1934, as amended, including the rules and regulations promulgated
thereunder.


 






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2.16        “Exchange
Program” means a program under which (a) outstanding Awards are surrendered or cancelled in exchange for awards
of the same type (which may have higher or lower exercise prices and different terms), awards of a different type, and/or cash,
(b) Participants would have the opportunity to transfer any outstanding Awards to a financial institution or other person
or entity selected by the Administrator, and/or (c) the exercise price of an outstanding Award is reduced or increased. The
Administrator will determine the terms and conditions of any Exchange Program in its sole discretion.


 


2.17       “Fair
Market Value” means, as of any date and unless the Administrator determines otherwise, the value of Common Stock determined
as follows:


 


(a)            If
the Common Stock is listed on any established stock exchange or a national market system, including without limitation the New
York Stock Exchange or the Nasdaq Global Select Market, the Nasdaq Global Market, or the Nasdaq Capital Market of The Nasdaq Stock
Market, its Fair Market Value will be the closing sales price for such stock (or, if no closing sales price was reported on that
date, as applicable, on the last Trading Day such closing sales price was reported) as quoted on such exchange or system on the
date of determination, as reported in The Wall Street Journal or such other source as the Administrator deems reliable;


 


(b)           If
the Common Stock is regularly quoted by a recognized securities dealer but selling prices are not reported, the Fair Market Value
of a Share will be the mean between the high bid and low asked prices for the Common Stock on the day of determination (or, if
no bids and asks were reported on that date, as applicable, on the last Trading Day such bids and asks were reported), as reported
in The Wall Street Journal or such other source as the Administrator deems reliable;


 


(c)            For
purposes of any Awards granted on the Registration Date, the Fair Market Value will be the initial price to the public as set forth
in the final prospectus included within the registration statement on Form S-1 filed with the Securities and Exchange Commission
for the initial public offering of the Common Stock; or


 


(d)            In
the absence of an established market for the Common Stock, the Fair Market Value will be determined in good faith by the Administrator.


 


2.18         “Fiscal
Year” means the fiscal year of the Company.


 


2.19        “Incentive
Stock Option” means an Option that by its terms qualifies and is otherwise intended to qualify as an incentive stock
option within the meaning of Code Section 422 and the regulations promulgated thereunder.


 


2.20         “Nonstatutory
Stock Option” means an Option that by its terms does not qualify or is not intended to qualify as an Incentive Stock
Option.


 


2.21         “Officer”
means a person who is an officer of the Company within the meaning of Section 16 of the Exchange Act and the rules and
regulations promulgated thereunder.


 


2.22         “Option”
means a stock option granted pursuant to the Plan.


 






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2.23          “Outside
Director” means a Director who is not an Employee.


 


2.24          “Parent”
means a “parent corporation,” whether now or hereafter existing, as defined in Code Section 424(e).


 


2.25          “Participant”
means the holder of an outstanding Award.


 


2.26          “Performance
Awards” means an Award which may be earned in whole or in part upon attainment of
performance goals or other vesting criteria as the Administrator may determine and which may be cash-
or stock-denominated and may be settled for cash, Shares or other securities or a combination of the foregoing under
Section 10.


 


2.27          “Performance
Period” means Performance Period as defined in Section 10.1.


 


2.28          “Period
of Restriction” means the period (if any) during which the transfer of Shares of Restricted Stock are subject to restrictions
and therefore, the Shares are subject to a substantial risk of forfeiture. Such restrictions may be based on the passage of time,
the achievement of target levels of performance, or the occurrence of other events as determined by the Administrator.


 


2.29          “Plan”
means this 2021 Equity Incentive Plan.


 


2.30          “Registration
Date” means the effective date of the first registration statement that is filed by the Company and declared effective
pursuant to Section 12(b) of the Exchange Act, with respect to any class of the Company’s securities.


 


2.31          “Restricted
Stock” means Shares issued pursuant to an Award of Restricted Stock under Section 8 of the Plan, or issued pursuant
to the early exercise of an Option.


 


2.32          “Restricted
Stock Unit” means a bookkeeping entry representing an amount equal to the Fair Market Value of one Share, granted pursuant
to Section 9. Each Restricted Stock Unit represents an unfunded and unsecured obligation of the Company.


 


2.33          “Rule 16b-3”
means Rule 16b-3 of the Exchange Act or any successor to Rule 16b-3, as in effect when discretion is being exercised
with respect to the Plan.


 


2.34          “Section 16b”
means Section 16(b) of the Exchange Act.


 


2.35          “Section 409A”
means Code Section 409A and the U.S. Treasury Regulations and guidance thereunder, and any applicable state law equivalent,
as each may be promulgated, amended or modified from time to time.


 


2.36          “Securities
Act” means the U.S. Securities Act of 1933, as amended, including the rules and regulations promulgated thereunder.


 


2.37          “Service
Provider” means an Employee, Director or Consultant.


 






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2.38          “Share”
means a share of the Common Stock, as adjusted in accordance with Section 14 of the Plan.


 


2.39          “Stock
Appreciation Right” means an Award, granted alone or in connection with an Option, that pursuant to Section 7 is
designated as a Stock Appreciation Right.


 


2.40          “Subsidiary”
means a “subsidiary corporation,” whether now or hereafter existing, as defined in Code Section 424(f).


 


2.41          “Trading
Day” means a day that the primary stock exchange, national market system, or other trading platform, as applicable, upon
which the Common Stock is listed (or otherwise trades regularly, as determined by the Administrator, in its sole discretion) is
open for trading.


 


2.42          “U.S.
Treasury Regulations” means the Treasury Regulations of the Code. Reference to a specific Treasury Regulation or Section of
the Code will include such Treasury Regulation or Section, any valid regulation promulgated under such Section, and any comparable
provision of any future legislation or regulation amending, supplementing or superseding such Section or regulation.


 


3.             Stock Subject to the Plan.


 


3.1           Stock
Subject to the Plan. Subject to adjustment upon changes in capitalization of the Company as provided in Section 14 and
the automatic increase set forth in Section 3.2, the maximum aggregate number of Shares that may be subject to Awards and
sold under the Plan will be equal to (a) 5,040,000 Shares, plus (b) any Shares subject to awards granted under the Company’s
2017 Equity Incentive Plan (the “2017 Plan”) that, after the date of stockholder approval of the Plan, expire
or otherwise terminate without having been exercised in full and Shares issued pursuant to awards granted under the 2017 Plan that
are forfeited to or repurchased by the Company due to failure to vest, with the maximum number of Shares to be added to the Plan
pursuant to clause (b) equal to 5,793,882 Shares. In addition, Shares may become available for issuance under Sections 3.2
and 3.3. The Shares may be authorized but unissued, or reacquired Common Stock.


 


3.2           Automatic
Share Reserve Increase. Subject to adjustment upon changes in capitalization of the Company as provided in Section 14,
the number of Shares available for issuance under the Plan will be increased on the first day of each Fiscal Year beginning with
the 2022 Fiscal Year, in an amount equal to the least of (a) 5,040,000 Shares, (b) five percent (5%) of the outstanding
Shares on the last day of the immediately preceding Fiscal Year, or (c) such number of Shares determined by the Board no later
than the last day of the immediately preceding Fiscal Year.


 






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3.3           Lapsed
Awards. If an Award expires or becomes unexercisable without having been exercised in full, is surrendered pursuant to an Exchange
Program, or, with respect to Restricted Stock, Restricted Stock Units, Performance Units or Performance Shares is forfeited to
or repurchased by the Company due to the failure to vest, the unpurchased Shares (or for Awards other than Options or Stock Appreciation
Rights the forfeited or repurchased Shares) which were subject thereto will become available for future grant or sale under the
Plan (unless the Plan has terminated). With respect to Stock Appreciation Rights, only Shares actually issued pursuant to a Stock
Appreciation Right will cease to be available under the Plan; all remaining Shares under Stock Appreciation Rights will remain
available for future grant or sale under the Plan (unless the Plan has terminated). Shares that have actually been issued under
the Plan under any Award will not be returned to the Plan and will not become available for future distribution under the Plan;
provided, however, that if Shares issued pursuant to Awards of Restricted Stock, Restricted Stock Units or Performance Awards are
repurchased by the Company or are forfeited to the Company due to the failure to vest, such Shares will become available for future
grant under the Plan. Shares used to pay the exercise price of an Award or to satisfy the tax liabilities or withholdings related
to an Award will become available for future grant or sale under the Plan. To the extent an Award under the Plan is paid out in
cash rather than Shares, such cash payment will not result in reducing the number of Shares available for issuance under the Plan.
Notwithstanding the foregoing and, subject to adjustment as provided in Section 14, the maximum number of Shares that may
be issued upon the exercise of Incentive Stock Options will equal the aggregate Share number stated in Section 3.1, plus,
to the extent allowable under Code Section 422 and the U.S. Treasury Regulations promulgated thereunder, any Shares that become
available for issuance under the Plan pursuant to Sections 3.2 and 3.3.


 


3.4           Share
Reserve. The Company, during the term of this Plan, will at all times reserve and keep available such number of Shares as will
be sufficient to satisfy the requirements of the Plan.


 


4.             Administration
of the Plan.


 


4.1           Procedure.


 


4.1.1        Multiple
Administrative Bodies. Different Committees with respect to different groups of Service Providers may administer the Plan.


 


4.1.2        Rule 16b-3.
To the extent desirable to qualify transactions hereunder as exempt under Rule 16b-3, the transactions contemplated hereunder
will be structured to satisfy the requirements for exemption under Rule 16b-3.


 


4.1.3        Other
Administration. Other than as provided above, the Plan will be administered by (A) the Board or (B) a Committee,
which Committee will be constituted to comply with Applicable Laws.


 


4.2           Powers
of the Administrator. Subject to the provisions of the Plan, and in the case of a Committee, subject to the specific duties
delegated by the Board to such Committee, the Administrator will have the authority, in its discretion:


 


(a)            to
determine the Fair Market Value;


 


(b)            to
select the Service Providers to whom Awards may be granted hereunder;


 


(c)            to
determine the number of Shares to be covered by each Award granted hereunder;


 






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(d)           to
approve forms of Award Agreements for use under the Plan;


 


(e)           to
determine the terms and conditions, not inconsistent with the terms of the Plan, of any Award granted hereunder. Such terms and
conditions include, but are not limited to, the exercise price, the time or times when Awards may be exercised (which may be based
on performance criteria), any vesting acceleration or waiver of forfeiture restrictions, and any restriction or limitation regarding
any Award or the Shares relating thereto (including but not limited to, temporarily suspending the exercisability of an Award if
the Administrator deems such suspension to be necessary or appropriate for administrative purposes or to comply with Applicable
Laws, provided that such suspension must be lifted prior to the expiration of the maximum term and post-termination exercisability
period of an Award), based in each case on such factors as the Administrator will determine;


 


(f)            to
institute and determine the terms and conditions of an Exchange Program, including, subject to Section 20.3, to unilaterally
implement an Exchange Program without the consent of the applicable Award holder;


 


(g)           to
construe and interpret the terms of the Plan and Awards granted pursuant to the Plan;


 


(h)           to
prescribe, amend and rescind rules and regulations relating to the Plan, including rules and regulations relating to
sub-plans established for the purpose of satisfying applicable non-U.S. laws or for qualifying for favorable tax treatment under
applicable non-U.S. laws;


 


(i)            to
modify or amend each Award (subject to Section 20.3), including but not limited to the discretionary authority to extend the
post-termination exercisability period of Awards and to extend the maximum term of an Option or Stock Appreciation Right (subject
to Sections 6.4 and 7.5);


 


(j)            to
allow Participants to satisfy withholding tax obligations in a manner prescribed in Section 16;


 


(k)           to
authorize any person to execute on behalf of the Company any instrument required to effect the grant of an Award previously granted
by the Administrator;


 


(l)            to
allow a Participant to defer the receipt of the payment of cash or the delivery of Shares that otherwise would be due to such Participant
under an Award; and


 


(m)          to
make all other determinations deemed necessary or advisable for administering the Plan.


 


4.3           Effect
of Administrator’s Decision. The Administrator’s decisions, determinations and interpretations will be final
and binding on all Participants and any other holders of Awards and will be given the maximum deference permitted by Applicable
Laws.


 






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5.             Eligibility.
Nonstatutory Stock Options, Stock Appreciation Rights, Restricted Stock, Restricted Stock Units, Performance Shares and Performance
Units may be granted to Service Providers. Incentive Stock Options may be granted only to Employees.


 


6.             Stock
Options.


 


6.1            Grant
of Options. Subject to the terms and provisions of the Plan, the Administrator, at any time and from time to time, may grant
Options to Service Providers in such amounts as the Administrator, in its sole discretion, will determine.


 


6.2           Option
Agreement. Each Award of an Option will be evidenced by an Award Agreement that will specify the exercise price, the term of
the Option, the number of Shares subject to the Option, the exercise restrictions, if any, applicable to the Option, and such other
terms and conditions as the Administrator, in its sole discretion, will determine.


 


6.3            Limitations.
Each Option will be designated in the Award Agreement as either an Incentive Stock Option or a Nonstatutory Stock Option. Notwithstanding
such designation, however, to the extent that the aggregate Fair Market Value of the Shares with respect to which Incentive Stock
Options are exercisable for the first time by the Participant during any calendar year (under all plans of the Company and any
Parent or Subsidiary) exceeds one hundred thousand dollars ($100,000), such Options will be treated as Nonstatutory Stock Options.
For purposes of this Section 6.3, Incentive Stock Options will be taken into account in the order in which they were
granted, the Fair Market Value of the Shares will be determined as of the time the Option with respect to such Shares is granted,
and calculation will be performed in accordance with Code Section 422 and the U.S. Treasury Regulations promulgated thereunder.


 


6.4            Term
of Option. The term of each Option will be stated in the Award Agreement; provided, however, that the term will be no more
than ten (10) years from the date of grant thereof. In the case of an Incentive Stock Option granted to a Participant who,
at the time the Incentive Stock Option is granted, owns stock representing more than ten percent (10%) of the total combined voting
power of all classes of stock of the Company or any Parent or Subsidiary, the term of the Incentive Stock Option will be five (5) years
from the date of grant or such shorter term as may be provided in the Award Agreement.


 


6.5            Option
Exercise Price and Consideration.


 


6.5.1        Exercise
Price. The per Share exercise price for the Shares to be issued pursuant to the exercise of an Option will be determined by
the Administrator, but will be no less than one hundred percent (100%) of the Fair Market Value per Share on the date of grant.
In addition, in the case of an Incentive Stock Option granted to an Employee who owns stock representing more than ten percent
(10%) of the voting power of all classes of stock of the Company or any Parent or Subsidiary, the per Share exercise price will
be no less than one hundred ten percent (110%) of the Fair Market Value per Share on the date of grant. Notwithstanding the foregoing
provisions of this Section 6.5.1, Options may be granted with a per Share exercise price of less than one hundred percent
(100%) of the Fair Market Value per Share on the date of grant pursuant to a transaction described in, and in a manner consistent
with, Code Section 424(a).


 






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6.5.2        Waiting
Period and Exercise Dates. At the time an Option is granted, the Administrator will fix the period within which the Option
may be exercised and will determine any conditions that must be satisfied before the Option may be exercised.


 


6.5.3        Form of
Consideration. The Administrator will determine the acceptable form of consideration for exercising an Option, including the
method of payment. In the case of an Incentive Stock Option, the Administrator will determine the acceptable form of consideration
at the time of grant. Such consideration may consist entirely of: (a) cash (including cash equivalents); (b) check; (c) promissory
note, to the extent permitted by Applicable Laws, (d) other Shares, provided that such Shares have a Fair Market Value on
the date of surrender equal to the aggregate exercise price of the Shares as to which such Option will be exercised and provided
further that accepting such Shares will not result in any adverse accounting consequences to the Company, as the Administrator
determines in its sole discretion; (e) consideration received by the Company under a cashless exercise program (whether through
a broker or otherwise) implemented by the Company in connection with the Plan; (f) by net exercise; (g) such other consideration
and method of payment for the issuance of Shares to the extent permitted by Applicable Laws, or (h) any combination of the
foregoing methods of payment. In making its determination as to the type of consideration to accept, the Administrator will consider
if acceptance of such consideration may be reasonably expected to benefit the Company.


 


6.6           Exercise
of Option.


 


6.6.1        Procedure
for Exercise; Rights as a Stockholder. Any Option granted hereunder will be exercisable according to the terms of the Plan
and at such times and under such conditions as determined by the Administrator and set forth in the Award Agreement. An Option
may not be exercised for a fraction of a Share.


 


An Option will be deemed
exercised when the Company receives: (a) notice of exercise (in such form as the Administrator may specify from time to time)
from the person entitled to exercise the Option, and (b) full payment for the Shares with respect to which the Option is exercised
(together with applicable tax withholding). Full payment may consist of any consideration and method of payment authorized by the
Administrator and permitted by the Award Agreement and the Plan. Shares issued upon exercise of an Option will be issued in the
name of the Participant or, if requested by the Participant, in the name of the Participant and his or her spouse. Until the Shares
are issued (as evidenced by the appropriate entry on the books of the Company or of a duly authorized transfer agent of the Company),
no right to vote or receive dividends or any other rights as a stockholder will exist with respect to the Shares subject to an
Option, notwithstanding the exercise of the Option. The Company will issue (or cause to be issued) such Shares promptly after the
Option is exercised. No adjustment will be made for a dividend or other right for which the record date is prior to the date the
Shares are issued, except as provided in Section 16 of the Plan.


 


Exercising an Option
in any manner will decrease the number of Shares thereafter available, both for purposes of the Plan and for sale under the Option,
by the number of Shares as to which the Option is exercised.


 






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6.6.2        Termination
of Relationship as a Service Provider. If a Participant ceases to be a Service Provider, other than upon the Participant’s
termination as the result of the Participant’s death or Disability, the Participant may exercise his or her Option, to the
extent that the Option is vested on the date of termination, within three (3) months of termination, or such shorter or longer
period of time, as is specified in the Award Agreement or in writing by the Administrator, in each case, in no event later than
the expiration of the term of such Option as set forth in the Award Agreement. Unless otherwise provided by the Administrator,
if on the date of termination the Participant is not vested as to his or her entire Option, the Shares covered by the unvested
portion of the Option will revert to the Plan. If after termination the Participant does not exercise his or her Option within
the time specified by the Administrator, the Option will terminate, and the Shares covered by such Option will revert to the Plan.


 


6.6.3        Disability
of Participant. If a Participant ceases to be a Service Provider as a result of the Participant’s Disability, the Participant
may exercise his or her Option within twelve (12) months of termination, or such longer or shorter period of time as is specified
in the Award Agreement or in writing by the Administrator (but in no event later than the expiration of the term of such Option
as set forth in the Award Agreement) to the extent the Option is vested on the date of termination. Unless otherwise provided by
the Administrator, if on the date of termination the Participant is not vested as to his or her entire Option, the Shares covered
by the unvested portion of the Option will revert to the Plan. If after termination the Participant does not exercise his or her
Option within the time specified herein, the Option will terminate, and the Shares covered by such Option will revert to the Plan.


 


6.6.4        Death
of Participant. If a Participant dies while a Service Provider, the Option may be exercised within twelve (12) months following
the Participant’s death, or within such longer or shorter period of time as is specified in the Award Agreement or in writing
by the Administrator (but in no event later than the expiration of the term of such Option as set forth in the Award Agreement)
to the extent that the Option is vested on the date of death, by the Participant’s designated beneficiary, provided such
beneficiary has been designated prior to the Participant’s death in a form (if any) acceptable to the Administrator. If no
such beneficiary has been designated by the Participant, then such Option may be exercised by the personal representative of the
Participant’s estate or by the person(s) to whom the Option is transferred pursuant to the Participant’s will
or in accordance with the laws of descent and distribution (each, a “Legal Representative”). If the Option is
exercised pursuant to this Section 6.6.4, Participant’s designated beneficiary or Legal Representative shall be subject
to the terms of this Plan and the Award Agreement, including but not limited to the restrictions on transferability and forfeitability
applicable to the Service Provider. Unless otherwise provided by the Administrator, if at the time of death Participant is not
vested as to his or her entire Option, the Shares covered by the unvested portion of the Option will immediately revert to the
Plan. If the Option is not so exercised within the time specified herein, the Option will terminate, and the Shares covered by
such Option will revert to the Plan.


 


6.6.5        Tolling
Expiration. A Participant’s Award Agreement may also provide that:


 






     -11-


     


    

 


(a)            if
the exercise of the Option following the cessation of Participant’s status as a Service Provider (other than upon the Participant’s
death or Disability) would result in liability under Section 16(b), then the Option will terminate on the earlier of (i) the
expiration of the term of the Option set forth in the Award Agreement, or (ii) the tenth (10th) day after the
last date on which such exercise would result in liability under Section 16(b); or


 


(b)           if
the exercise of the Option following the cessation of the Participant’s status as a Service Provider (other than upon the
Participant’s death or Disability) would be prohibited at any time solely because the issuance of Shares would violate the
registration requirements under the Securities Act, then the Option will terminate on the earlier of (i) the expiration of
the term of the Option or (ii) the expiration of a period of thirty (30) days after the cessation of the Participant’s
status as a Service Provider during which the exercise of the Option would not be in violation of such registration requirements.


 


7.             Stock
Appreciation Rights.


 


7.1             Grant
of Stock Appreciation Rights. Subject to the terms and conditions of the Plan, a Stock Appreciation Right may be granted to
Service Providers at any time and from time to time as will be determined by the Administrator, in its sole discretion.


 


7.2            Number
of Shares. The Administrator will have complete discretion to determine the number of Shares subject to any Award of Stock
Appreciation Rights.


 


7.3            Exercise
Price and Other Terms. The per Share exercise price for the Shares that will determine the amount of the payment to be received
upon exercise of a Stock Appreciation Right as set forth in Section 7.6 will be determined by the Administrator and will be
no less than one hundred percent (100%) of the Fair Market Value per Share on the date of grant. Otherwise, the Administrator,
subject to the provisions of the Plan, will have complete discretion to determine the terms and conditions of Stock Appreciation
Rights granted under the Plan.


 


7.4            Stock
Appreciation Right Agreement. Each Stock Appreciation Right grant will be evidenced by an Award Agreement that will specify
the exercise price, the term of the Stock Appreciation Right, the conditions of exercise, and such other terms and conditions as
the Administrator, in its sole discretion, will determine.


 


7.5            Expiration
of Stock Appreciation Rights. A Stock Appreciation Right granted under the Plan will expire upon the date determined by the
Administrator, in its sole discretion, and set forth in the Award Agreement. Notwithstanding the foregoing, the rules of Section 6.4
relating to the maximum term and Section 6.5 relating to exercise also will apply to Stock Appreciation Rights.


 


7.6            Payment
of Stock Appreciation Right Amount. Upon exercise of a Stock Appreciation Right, a Participant will be entitled to receive
payment from the Company in an amount determined by multiplying:


 


(a)            The
difference between the Fair Market Value of a Share on the date of exercise over the exercise price; times


 


(b)            The
number of Shares with respect to which the Stock Appreciation Right is exercised.


 






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At the discretion
of the Administrator, the payment upon Stock Appreciation Right exercise may be in cash, in Shares of equivalent value, or in
some combination thereof.


 


8.            Restricted
Stock.


 


8.1         Grant
of Restricted Stock. Subject to the terms and provisions of the Plan, the Administrator, at any time and from time to time,
may grant Shares of Restricted Stock to Service Providers in such amounts as the Administrator, in its sole discretion, will determine.


 


8.2         Restricted
Stock Agreement. Each Award of Restricted Stock will be evidenced by an Award Agreement that will specify the Period of Restriction
(if any), the number of Shares granted, and such other terms and conditions as the Administrator, in its sole discretion, will
determine. Unless the Administrator determines otherwise, the Company as escrow agent will hold Shares of Restricted Stock until
the restrictions on such Shares have lapsed.


 


8.3         Transferability.
Except as provided in this Section 8 or as the Administrator determines, Shares of Restricted Stock may not be sold, transferred,
pledged, assigned, or otherwise alienated or hypothecated until the end of the applicable Period of Restriction.


 


8.4          Other
Restrictions. The Administrator, in its sole discretion, may impose such other restrictions on Shares of Restricted Stock
as it may deem advisable or appropriate.


 


8.5         Removal
of Restrictions. Except as otherwise provided in this Section 8, Shares of Restricted Stock covered by each Restricted
Stock grant made under the Plan will be released from escrow as soon as practicable after the last day of the Period of Restriction
or at such other time as the Administrator may determine. The Administrator, in its discretion, may accelerate the time at which
any restrictions will lapse or be removed.


 


8.6         Voting
Rights. During the Period of Restriction, Service Providers holding Shares of Restricted Stock granted hereunder may exercise
full voting rights with respect to those Shares, unless the Administrator determines otherwise.


 


8.7          Dividends
and Other Distributions. During the Period of Restriction, Service Providers holding Shares of Restricted Stock will be entitled
to receive all dividends and other distributions paid with respect to such Shares, unless the Administrator provides otherwise.
If any such dividends or distributions are paid in Shares, the Shares will be subject to the same restrictions on transferability
and forfeitability as the Shares of Restricted Stock with respect to which they were paid.


 


8.8          Return
of Restricted Stock to Company. On the date set forth in the Award Agreement, the Restricted Stock for which restrictions
have not lapsed will revert to the Company and again will become available for grant under the Plan.


 


9.            Restricted
Stock Units.


 


9.1          Grant.
Restricted Stock Units may be granted at any time and from time to time as determined by the Administrator. After the Administrator
determines that it will grant Restricted Stock Units, it will advise the Participant in an Award Agreement of the terms, conditions,
and restrictions related to the grant, including the number of Restricted Stock Units.


 






    -13-


     


    




 


9.2        
   Vesting Criteria and Other Terms. The Administrator will set vesting criteria in
its discretion, which, depending on the extent to which the criteria are met, will determine the number of Restricted Stock
Units that will be paid out to the Participant. The Administrator may set vesting criteria based upon the achievement of
Company-wide, divisional, business unit, or individual goals (including, but not limited to, continued employment or
service), applicable federal or state securities laws or any other basis determined by the Administrator in its
discretion.


 


9.3            Earning
Restricted Stock Units. Upon meeting the applicable vesting criteria, the Participant will be entitled to receive a payout
as determined by the Administrator. Notwithstanding the foregoing, at any time after the grant of Restricted Stock Units, the
Administrator, in its sole discretion, may reduce or waive any vesting criteria that must be met to receive a payout.


 


9.4  
          Form and Timing of Payment. Payment of
earned Restricted Stock Units will be made at the time(s) determined by the Administrator and set forth in the Award
Agreement. The Administrator, in its sole discretion, may settle earned Restricted Stock Units in cash, Shares, or a
combination of both.


 


9.5           
  Cancellation. On the date set forth in the Award Agreement, all unearned
Restricted Stock Units will be forfeited to the Company.


 


10.           Performance
Awards.


 


10.1           Award
Agreement. Each Performance Award will be evidenced by an Award Agreement that will specify any time period during which any
performance objectives or other vesting provisions will be measured (“Performance Period”), and such other
terms and conditions as the Administrator determines. Each Performance Award will have an initial value that is determined by
the Administrator on or before its date of grant.


 


10.2           Objectives
or Vesting Provisions and Other Terms. The Administrator will set any objectives or vesting provisions that, depending on
the extent to which any such objectives or vesting provisions are met, will determine the value of the payout for the Performance
Awards.  The Administrator may set vesting criteria based upon the achievement of Company-wide, divisional, business unit, or
individual goals (including, but not limited to, continued employment or service), applicable federal or state securities laws, or
any other basis determined by the Administrator in its discretion.


 


10.3          Earning
Performance Awards. After an applicable Performance Period has ended, the holder of a Performance Award will be entitled to
receive a payout for the Performance Award earned by the Participant over the Performance Period. The Administrator, in its discretion,
may reduce or waive any performance objectives or other vesting provisions for such Performance Award.


 






    -14-


     


    

 


10.4          Form and
Timing of Payment. Payment of earned Performance Awards will be made at the time(s) determined by the Administrator and
set forth in the Award Agreement. The Administrator, in its sole discretion, may settle earned Performance Awards in cash, Shares,
or a combination of both.


 


10.5          Cancellation
of Performance Awards. On the date set forth in the Award Agreement, all unearned or unvested Performance Awards will be forfeited
to the Company, and again will be available for grant under the Plan.


 


11.          Compliance
With Section 409A. Awards will be designed and operated in such a manner that they are either exempt from the application
of, or comply with, the requirements of Section 409A such that the grant, payment, settlement or deferral will not be subject
to the additional tax or interest applicable under Section 409A, except as otherwise determined in the sole discretion of
the Administrator. The Plan and each Award Agreement under the Plan is intended to be exempt from or meet the requirements
of Section 409A and will be construed and interpreted in accordance with such intent (including with respect to any ambiguities
or ambiguous terms), except as otherwise determined in the sole discretion of the Administrator. To the extent that an Award or
payment, or the settlement or deferral thereof, is subject to Section 409A the Award will be granted, paid, settled or deferred
in a manner that will meet the requirements of Section 409A, such that the grant, payment, settlement or deferral will not
be subject to the additional tax or interest applicable under Section 409A. In no event will the Company or any of its Parent
or Subsidiaries have any responsibility, liability, or obligation to reimburse, indemnify, or hold harmless a Participant (or
any other person) in respect of Awards, for any taxes, penalties or interest that may be imposed on, or other costs incurred by,
Participant (or any other person) as a result of Section 409A.


 


12.          Leaves
of Absence/Transfer Between Locations. Unless the Administrator provides otherwise or as otherwise required by Applicable
Laws, vesting of Awards granted hereunder will be suspended during any unpaid leave of absence. A Participant will not cease to
be an Employee in the case of (a) any leave of absence approved by the Company or (b) transfers between locations of
the Company or between the Company, its Parent, or any of its Subsidiaries. For purposes of Incentive Stock Options, no such leave
may exceed three (3) months, unless reemployment upon expiration of such leave is guaranteed by statute or contract. If reemployment
upon expiration of a leave of absence approved by the Company is not so guaranteed, then six (6) months following the first
(1st) day of such leave, any Incentive Stock Option held by the Participant will cease to be treated as an Incentive
Stock Option and will be treated for tax purposes as a Nonstatutory Stock Option.


 


13.         Limited
Transferability of Awards. Unless determined otherwise by the Administrator, Awards may not be sold, pledged, assigned, hypothecated,
transferred, or disposed of in any manner other than by will or by the laws of descent and distribution (which, for purposes of
clarification, shall be deemed to include through a beneficiary designation if available in accordance with Section 6.6),
and may be exercised, during the lifetime of the Participant, only by the Participant. If the Administrator makes an Award transferable,
such Award will contain such additional terms and conditions as the Administrator deems appropriate.


 






    -15-


     


    

 


14.          Adjustments;
Dissolution or Liquidation; Merger or Change in Control.


 


14.1            Adjustments.
In the event that any dividend or other distribution (whether in the form of cash, Shares, other securities, or other property),
recapitalization, stock split, reverse stock split, reorganization, merger, consolidation, split-up, spin-off, combination, reclassification,
repurchase, or exchange of Shares or other securities of the Company, or other change in the corporate structure of the Company
affecting the Shares occurs (other than any ordinary dividends or other ordinary distributions), the Administrator, in order to
prevent diminution or enlargement of the benefits or potential benefits intended to be made available under the Plan, will adjust
the number and class of shares of stock that may be delivered under the Plan and/or the number, class, and price of shares of
stock covered by each outstanding Award, and numerical Share limits in Section 3.


 


14.2             Dissolution
or Liquidation. In the event of the proposed dissolution or liquidation of the Company, the Administrator will notify each
Participant as soon as practicable prior to the effective date of such proposed transaction. To the extent it has not been previously
exercised, an Award will terminate immediately prior to the consummation of such proposed action.


 


14.3            Merger
or Change in Control. In the event of a merger of the Company with or into another corporation or other entity or a Change
in Control, each outstanding Award will be treated as the Administrator determines (subject to the provisions of the following
paragraph) without a Participant’s consent, including, without limitation, that (a) Awards will be assumed, or substantially
equivalent awards will be substituted, by the acquiring or succeeding corporation (or an affiliate thereof) with appropriate adjustments
as to the number and kind of shares and prices; (b) upon written notice to a Participant, that the Participant’s Awards
will terminate upon or immediately prior to the consummation of such merger or Change in Control; (c) outstanding Awards
will vest and become exercisable, realizable, or payable, or restrictions applicable to an Award will lapse, in whole or in part
prior to or upon consummation of such merger or Change in Control, and, to the extent the Administrator determines, terminate
upon or immediately prior to the effectiveness of such merger or Change in Control; (d) (i) the termination of an Award
in exchange for an amount of cash and/or property, if any, equal to the amount that would have been attained upon the exercise
of such Award or realization of the Participant’s rights as of the date of the occurrence of the transaction (and, for the
avoidance of doubt, if as of the date of the occurrence of the transaction the Administrator determines in good faith that no
amount would have been attained upon the exercise of such Award or realization of the Participant’s rights, then such Award
may be terminated by the Company without payment), or (ii) the replacement of such Award with other rights or property selected
by the Administrator in its sole discretion; or (e) any combination of the foregoing. In taking any of the actions permitted
under this Section 14.3, the Administrator will not be obligated to treat all Awards, all Awards held by a Participant, all
Awards of the same type, or all portions of Awards, similarly.


 


In the event that the
successor corporation does not assume or substitute for the Award (or portion thereof), the Participant will fully vest in and
have the right to exercise his or her outstanding Options and Stock Appreciation Rights (or portions thereof) not assumed or substituted
for, including Shares as to which such Awards would not otherwise be vested or exercisable, all restrictions on Restricted Stock,
Restricted Stock Units, Performance Shares and Performance Units (or portions thereof) not assumed or substituted for will lapse,
and, with respect to Awards with performance-based vesting (or portions thereof) not assumed or substituted for, all performance
goals or other vesting criteria will be deemed achieved at one hundred percent (100%) of target levels and all other terms and
conditions met, in each case, unless specifically provided otherwise under the applicable Award Agreement or other written agreement
between the Participant and the Company or any of its Subsidiaries or Parents, as applicable. In addition, unless specifically
provided otherwise under the applicable Award Agreement or other written agreement between the Participant and the Company or
any of its Subsidiaries or Parents, as applicable, if an Option or Stock Appreciation Right (or portion thereof) is not assumed
or substituted in the event of a merger or Change in Control, the Administrator will notify the Participant in writing or electronically
that the Option or Stock Appreciation Right (or its applicable portion) will be exercisable for a period of time determined by
the Administrator in its sole discretion, and the Option or Stock Appreciation Right (or its applicable portion) will terminate
upon the expiration of such period.


 






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For the purposes of
this Section 14.3 and Section 14.4 below, an Award will be considered assumed if, following the merger or Change in
Control, the Award confers the right to purchase or receive, for each Share subject to the Award immediately prior to the merger
or Change in Control, the consideration (whether stock, cash, or other securities or property) received in the merger or Change
in Control by holders of Common Stock for each Share held on the effective date of the transaction (and if holders were offered
a choice of consideration, the type of consideration chosen by the holders of a majority of the outstanding Shares); provided,
however, that if such consideration received in the merger or Change in Control is not solely common stock of the successor corporation
or its Parent, the Administrator may, with the consent of the successor corporation, provide for the consideration to be received
upon the exercise of an Option or Stock Appreciation Right or upon the payout of a Restricted Stock Unit, Performance Unit or
Performance Share, for each Share subject to such Award, to be solely common stock of the successor corporation or its Parent
equal in fair market value to the per share consideration received by holders of Common Stock in the merger or Change in Control.


 


Notwithstanding anything
in this Section 14.3 to the contrary, an Award that vests, is earned or paid-out upon the satisfaction of one or more performance
goals will not be considered assumed if the Company or its successor modifies any of such performance goals without the Participant’s
consent, in all cases, unless specifically provided otherwise under the applicable Award Agreement or other written agreement
between the Participant and the Company or any of its Subsidiaries or Parents, as applicable; provided, however, a modification
to such performance goals only to reflect the successor corporation’s post-Change in Control corporate structure will not
be deemed to invalidate an otherwise valid Award assumption.


 


Notwithstanding anything
in this Section 14.3 to the contrary, and unless otherwise provided in an Award Agreement, if an Award that vests, is earned
or paid-out under an Award Agreement is subject to Section 409A and if the change in control definition contained in the
Award Agreement (or other agreement related to the Award, as applicable) does not comply with the definition of “change
in control” for purposes of a distribution under Section 409A, then any payment of an amount that is otherwise accelerated
under this Section will be delayed until the earliest time that such payment would be permissible under Section 409A
without triggering any penalties applicable under Section 409A.


 






    -17-


     


    

 


14.4            Outside
Director Awards. With respect to Awards granted to an Outside Director, the Outside Director will fully vest in and have the
right to exercise Options and/or Stock Appreciation Rights as to all of the Shares underlying such Award, including those Shares
which otherwise would not be vested or exercisable, all restrictions on Restricted Stock and Restricted Stock Units will lapse,
and, with respect to Awards with performance-based vesting, all performance goals or other vesting criteria will be deemed achieved
at one hundred percent (100%) of target levels and all other terms and conditions met, unless specifically provided otherwise
under the applicable Award Agreement or other written agreement between the Participant and the Company or any of its Parent or
Subsidiaries, as applicable. 


 


15.            Tax
Withholding.


 


15.1            Withholding
Requirements. Prior to the delivery of any Shares or cash pursuant to an Award (or exercise thereof) or such earlier time
as any tax withholdings are due, the Company (or any of its Parent, Subsidiaries, or affiliates employing or retaining the services
of a Participant, as applicable) will have the power and the right to deduct or withhold, or require a Participant to remit to
the Company (or any of its Parent, Subsidiaries, or affiliates, as applicable) or a relevant tax authority, an amount sufficient
to satisfy U.S. federal, state, local, non-U.S., and other taxes (including the Participant’s FICA obligation) required
to be withheld or paid with respect to such Award (or exercise thereof).


 


15.2            Withholding
Arrangements. The Administrator, in its sole discretion and pursuant to such procedures as it may specify from time to time,
may permit a Participant to satisfy such tax liability or withholding obligation, in whole or in part by such methods as the Administrator
shall determine, including, without limitation, (a) paying cash, (b) electing to have the Company withhold otherwise
deliverable cash or Shares having a fair market value equal to the minimum statutory amount required to be withheld or such greater
amount as the Administrator may determine if such amount would not have adverse accounting consequences, as the Administrator
determines in its sole discretion, (c) delivering to the Company already-owned Shares having a fair market value equal to
the statutory amount required to be withheld or such greater amount as the Administrator may determine, in each case, provided
the delivery of such Shares will not result in any adverse accounting consequences, as the Administrator determines in its sole
discretion, (d) selling a sufficient number of Shares otherwise deliverable to the Participant through such means as the
Administrator may determine in its sole discretion (whether through a broker or otherwise) equal to the amount required to be
withheld or paid, (e) such other consideration and method of payment for the meeting of tax liabilities or withholding obligations
as the Administrator may determine to the extent permitted by Applicable Laws, or (f) any combination of the foregoing methods
of payment. The amount of the withholding requirement will be deemed to include any amount which the Administrator agrees may
be withheld at the time the election is made, not to exceed the amount determined by using the maximum federal, state or local
marginal income tax rates applicable to the Participant with respect to the Award on the date that the amount of tax to be withheld
is to be determined or such greater amount as the Administrator may determine if such amount would not have adverse accounting
consequences, as the Administrator determines in its sole discretion. The fair market value of the Shares to be withheld or delivered
will be determined as of the date that the taxes are required to be withheld.


 






    -18-


     


    

 





16.            No
Effect on Employment or Service. Neither the Plan nor any Award will confer upon a Participant any right with respect to continuing
the Participant’s relationship as a Service Provider with the Company or its Subsidiaries or Parents, as applicable, nor
will they interfere in any way with the Participant’s right or the right of the Company and its Subsidiaries or Parents,
as applicable, to terminate such relationship at any time, with or without cause, to the extent permitted by Applicable Laws.


 


17.          Date
of Grant. The date of grant of an Award will be, for all purposes, the date on which the Administrator makes the determination
granting such Award, or such other later date as is determined by the Administrator. Notice of the determination will be provided
to each Participant within a reasonable time after the date of such grant.


 


18.           Term
of Plan. Subject to Section 23 of the Plan, the Plan will become effective as of one business day prior to the Registration
Date. The Plan will continue in effect until terminated under Section 20, but (a) no Options that qualify as incentive
stock options within the meaning of Code Section 422 may be granted after ten (10) years from the earlier of the Board
or stockholder approval of the Plan and (b) Section 3.2 relating to automatic share reserve increases will operate only
until the ten (10) year anniversary of the earlier of the Board or stockholder approval of the Plan.


 


19.            Amendment
and Termination of the Plan.


 


19.1            Amendment
and Termination. The Administrator may at any time amend, alter, suspend or terminate the Plan.


 


19.2            Stockholder
Approval. The Company will obtain stockholder approval of any Plan amendment to the extent necessary and desirable to comply
with Applicable Laws.


 


19.3            Effect
of Amendment or Termination. No amendment, alteration, suspension or termination of the Plan will materially impair the rights
of any Participant, unless mutually agreed otherwise between the Participant and the Administrator, which agreement must be in
writing and signed by the Participant and the Company. Termination of the Plan will not affect the Administrator’s ability
to exercise the powers granted to it hereunder with respect to Awards granted under the Plan prior to the date of such termination.


 


20.            Conditions
Upon Issuance of Shares.


 


20.1           Legal
Compliance. Shares will not be issued pursuant to the exercise of an Award unless the exercise of such Award and the issuance
and delivery of such Shares will comply with Applicable Laws and will be further subject to the approval of counsel for the Company
with respect to such compliance.


 


20.2           Investment
Representations. As a condition to the exercise of an Award, the Company may require the person exercising such Award to represent
and warrant at the time of any such exercise that the Shares are being purchased only for investment and without any present intention
to sell or distribute such Shares if, in the opinion of counsel for the Company, such a representation is required.


 






    -19-


     


    

 


21.            Inability
to Obtain Authority. The inability of the Company to obtain authority from any regulatory body having jurisdiction or to complete
or comply with the requirements of any registration or other qualification of the Shares under any U.S. state or federal law or
non-U.S. law or under the rules and regulations of the Securities and Exchange Commission, the stock exchange on which Shares
of the same class are then listed, or any other governmental or regulatory body, which authority, registration, qualification
or rule compliance is deemed by the Company’s counsel to be necessary or advisable for the issuance and sale of any
Shares hereunder, will relieve the Company of any liability in respect of the failure to issue or sell such Shares as to which
such requisite authority, registration, qualification or rule compliance will not have been obtained.


 


22.            Stockholder
Approval. The Plan will be subject to approval by the stockholders of the Company within twelve (12) months after the date
the Plan is adopted by the Board. Such stockholder approval will be obtained in the manner and to the degree required under Applicable
Laws.


 


23.            Forfeiture
Events. The Administrator may specify in an Award Agreement that the Participant’s rights, payments, and benefits with
respect to an Award will be subject to the reduction, cancellation, forfeiture, recoupment, reimbursement, or reacquisition upon
the occurrence of certain specified events, in addition to any otherwise applicable vesting or performance conditions of an Award.
Notwithstanding any provisions to the contrary under this Plan, an Award shall be subject to the Company’s clawback policy
as may be established and/or amended from time to time to comply with Applicable Laws (including without limitation pursuant to
the listing standards of any national securities exchange or association on which the Company’s securities are listed or
as may be required by the Dodd-Frank Wall Street Reform and Consumer Protection Act) (the “Clawback Policy”).
The Administrator may require a Participant to forfeit, return or reimburse the Company all or a portion of the Award and any
amounts paid thereunder pursuant to the terms of the Clawback Policy or as necessary or appropriate to comply with Applicable
Laws. Unless this Section 24 specifically is mentioned and waived in an Award Agreement or other document, no recovery of
compensation under a Clawback Policy or otherwise will constitute an event that triggers or contributes to any right of a Participant
to resign for “good reason” or “constructive termination” (or similar term) under any agreement with the
Company or any Parent or Subsidiary of the Company.


 


*          *          *


 






    -20-


     


    



 


EDGEWISE THERAPEUTICS, INC.





 


2021
EQUITY INCENTIVE PLAN


 


STOCK OPTION AGREEMENT


 


NOTICE OF STOCK OPTION GRANT


 


Unless otherwise defined
herein, the terms defined in the Edgewise Therapeutics, Inc. 2021 Equity Incentive Plan (the “Plan”) shall
have the same defined meanings in this Stock Option Agreement, which includes the Notice of Stock Option Grant (the “Notice
of Grant”), the Terms and Conditions of Stock Option Grant, attached hereto as Exhibit A, the Exercise
Notice, attached hereto as Exhibit B, and all other exhibits, appendices, and addenda attached hereto (together,
the “Option Agreement”).


 


Participant Name:


 


Address:


 


The undersigned Participant
has been granted an Option to purchase Common Stock of the Company, subject to the terms and conditions of the Plan and this Option
Agreement, as follows:


 


	 	Grant Number:	 	 ________________________________________________________________	 
	 	 	 	 	 
	 	Date of Grant:	 	 ________________________________________________________________	 
	 	 	 	 	 
	 	Vesting Commencement
    Date:	 	 ________________________________________________________________	 
	 	 	 	 	 
	 	Exercise Price per Share:	 	$_______________________________________________________________	 
	 	 	 	 	 
	 	Total Number of Shares Granted:	 	 ________________________________________________________________	 
	 	 	 	 	 
	 	Total Exercise Price:	 	$_______________________________________________________________	 
	 	 	 	 	 
	 	Type of Option:	 	___ Incentive Stock Option	 
	 	 	 	 	 
	 		 	___ Nonstatutory Stock
    Option	 
	 	 	 	 	 
	 	Term/Expiration Date:	 	 ________________________________________________________________	 
	 	 	 	 	 
	 	Vesting
    Schedule:	 	 	 




 


Subject
to any acceleration provisions contained in the Plan, this Option Agreement or any other written agreement between Participant
and the Company (or any Parent or Subsidiary of the Company, as applicable) governing the terms of this Option, this Option shall
vest and be exercisable, in whole or in part, according to the following vesting schedule: [______].


 






     


     


    

 


Termination
Period:


 


This Option shall be
exercisable, to the extent vested, for three (3) months after Participant ceases to be a Service Provider, unless such termination
is due to Participant’s death or Disability, in which case this Option shall be exercisable, to the extent vested, for twelve
(12) months after Participant ceases to be a Service Provider. Notwithstanding the foregoing sentence, in no event may this Option
be exercised after the Term/Expiration Date as provided above and this Option may be subject to earlier termination as provided
in Section 14 of the Plan.


 


By Participant’s
signature and the signature of the representative of the Company below, Participant and the Company agree that this Option is granted
under and governed by the terms and conditions of the Plan and this Option Agreement, including the Terms and Conditions of Stock
Option Grant, attached hereto as Exhibit A, the Exercise Notice, attached hereto as Exhibit B, and all
other exhibits, appendices and addenda attached hereto, all of which are made a part of this document. Participant acknowledges
receipt of a copy of the Plan. Participant has reviewed the Plan and this Option Agreement in their entirety, has had an opportunity
to obtain the advice of counsel prior to executing this Option Agreement and fully understands all provisions of the Plan and the
Option Agreement. Participant hereby agrees to accept as binding, conclusive and final all decisions or interpretations of the
Administrator upon any questions relating to the Plan or this Option Agreement. Participant further agrees to notify the Company
upon any change in Participant’s residence address indicated below.


 


	PARTICIPANT	 	EDGEWISE
    THERAPEUTICS, INC.
	 	 	 
	 	 	 
	Signature	 	Signature
	 	 	 
	Print Name	 	Print Name
	 	 	 
		 	Title
	 	 	 
	Residence Address:	 	 
	 	 	 
	 	 	 




 






    	 	-2-	 



     


    

 


EXHIBIT A


 


EDGEWISE THERAPEUTICS, INC.


 


2021
EQUITY INCENTIVE PLAN


 


STOCK OPTION AGREEMENT


 


TERMS AND CONDITIONS OF STOCK OPTION
GRANT


 


1.            Grant
of Option.


 


(a)            The
Company hereby grants to the individual (“Participant”) named in the Notice of Stock Option Grant of this Option
Agreement (the “Notice of Grant”), an option (the “Option”) to purchase the number of Shares
set forth in the Notice of Grant, at the exercise price per Share set forth in the Notice of Grant (the “Exercise Price”),
subject to all of the terms and conditions in this Option Agreement and the Plan, which is incorporated herein by reference. Subject
to Section 19 of the Plan, in the event of a conflict between the terms and conditions of the Plan and this Option Agreement,
the terms and conditions of the Plan shall prevail.


 


(b)            For
U.S. taxpayers, if designated in the Notice of Grant as an Incentive Stock Option (“ISO”), this Option is intended
to qualify as an Incentive Stock Option as defined in Section 422 of the Code. Nevertheless, to the extent that it exceeds
the $100,000 rule of Code Section 422(d), this Option shall be treated as a Nonstatutory Stock Option (“NSO”).
Further, if for any reason this Option (or portion thereof) shall not qualify as an ISO, then, to the extent of such nonqualification,
such Option (or portion thereof) shall be regarded as a NSO granted under the Plan. In no event shall the Administrator, the Company
or any Parent or Subsidiary or any of their respective employees or directors have any liability to Participant (or any other person)
due to the failure of the Option to qualify for any reason as an ISO.


 


(c)            For
non-U.S. taxpayers, the Option will be designated as an NSO.


 


2.            Vesting
Schedule. Except as provided in Section 3, the Option awarded by this Option Agreement will vest in accordance with the
vesting provisions set forth in the Notice of Grant. Unless specifically provided otherwise in this Option Agreement or other written
agreement between Participant and the Company or any Parent or Subsidiary of the Company, as applicable, Shares subject to this
Option that are scheduled to vest on a certain date or upon the occurrence of a certain condition will not vest in accordance with
any of the provisions of this Option Agreement, unless Participant will have been continuously a Service Provider from the Date
of Grant until the date such vesting occurs.


 


3.            Administrator
Discretion. The Administrator, in its discretion, may accelerate the vesting of the balance, or some lesser portion of the
balance, of the unvested Option at any time, subject to the terms of the Plan. If so accelerated, such Option will be considered
as having vested as of the date specified by the Administrator.


 






    	 	-1-	 



     


    

 


4.            Exercise
of Option.


 


(a)            Right
to Exercise. This Option shall be exercisable during its term in accordance with the Vesting Schedule set out in the Notice
of Grant and with the applicable provisions of the Plan and this Option Agreement.


 


(b)            Method
of Exercise. This Option shall be exercisable by delivery of an exercise notice (the “Exercise Notice”)
in the form attached as Exhibit B to the Notice of Grant or in a manner and pursuant to such procedures as the Administrator
may determine, which shall state the election to exercise the Option, the number of Shares with respect to which the Option is
being exercised (the “Exercised Shares”), and such other representations and agreements as may be required by
the Company. The Exercise Notice shall be completed by Participant and delivered to the Company, accompanied by payment of the
aggregate Exercise Price as to all Exercised Shares, together with any applicable Tax Obligations (as defined below). This Option
shall be deemed to be exercised upon receipt by the Company of such fully executed Exercise Notice accompanied by the aggregate
Exercise Price, together with any applicable Tax Obligations.


 


No Shares shall be issued
pursuant to the exercise of an Option unless such issuance and such exercise comply with Applicable Laws. Assuming such compliance,
for income tax purposes the Shares shall be considered transferred to Participant on the date on which the Option is exercised
with respect to such Shares.


 


5.            Method
of Payment. Payment of the aggregate Exercise Price shall be by any of the following, or a combination thereof, at the election
of Participant:


 


(a)            cash;


 


(b)            check;


 


(c)            consideration
received by the Company under a formal cashless exercise program adopted by the Company in connection with the Plan; or


 


(d)            if
Participant is a U.S. employee, surrender of other Shares which (i) shall be valued at its fair market value on the date of
surrender, and (ii) must be owned free and clear of any liens, claims, encumbrances or security interests, if accepting such
Shares, in the sole discretion of the Administrator, shall not result in any adverse accounting consequences to the Company.


 


A non-U.S. resident’s
methods of exercise may be restricted by the terms and conditions of any appendix to this Agreement for Participant’s country
(including the Country Addendum, as defined below).


 


6.            Non-Transferability
of Option. This Option may not be transferred in any manner otherwise than by will or by the laws of descent or distribution
and may be exercised during the lifetime of Participant only by Participant.


 






    	 	-2-	 



     


    

 


7.            Term
of Option. This Option may be exercised only within the term set out in the Notice of Grant, and may be exercised during such
term only in accordance with the Plan and the terms of this Option Agreement.


 


8.            Tax
Obligations.


 


(a)            Responsibility
for Taxes. Participant acknowledges that, regardless of any action taken by the Company or, if different, Participant’s
employer or any Parent or Subsidiary to which Participant is providing services (together, the “Service Recipients”),
the ultimate liability for any tax and/or social insurance liability obligations and requirements in connection with the Option,
including, without limitation, (i) all federal, state, and local taxes (including Participant’s Federal Insurance Contributions
Act (FICA) obligations) that are required to be withheld by any Service Recipient or other payment of tax-related items related
to Participant’s participation in the Plan and legally applicable to Participant, (ii) Participant’s and, to the
extent required by any Service Recipient, the Service Recipient’s fringe benefit tax liability, if any, associated with the
grant, vesting, or exercise of the Option or sale of Shares, and (iii) any other Service Recipient taxes the responsibility
for which Participant has, or has agreed to bear, with respect to the Option (or exercise thereof or issuance of Shares thereunder)
(collectively, the “Tax Obligations”), is and remains Participant’s sole responsibility and may exceed
the amount actually withheld by the applicable Service Recipient(s). Participant further acknowledges that no Service Recipient
(A) makes any representations or undertakings regarding the treatment of any Tax Obligations in connection with any aspect
of the Option, including, but not limited to, the grant, vesting or exercise of the Option, the subsequent sale of Shares acquired
pursuant to such exercise and the receipt of any dividends or other distributions, and (B) makes any commitment to and is
under any obligation to structure the terms of the grant or any aspect of the Option to reduce or eliminate Participant’s
liability for Tax Obligations or achieve any particular tax result. Further, if Participant is subject to Tax Obligations in more
than one jurisdiction between the Date of Grant and the date of any relevant taxable or tax withholding event, as applicable, Participant
acknowledges that the applicable Service Recipient(s) (or former employer, as applicable) may be required to withhold or account
for Tax Obligations in more than one jurisdiction. If Participant fails to make satisfactory arrangements for the payment of any
required Tax Obligations hereunder at the time of the applicable taxable event, Participant acknowledges and agrees that the Company
may refuse to issue or deliver the Shares.


 


(b)            Tax
Withholding. Pursuant to such procedures as the Administrator may specify from time to time, the applicable Service Recipient(s) will
withhold the amount required to be withheld for the payment of Tax Obligations. The Administrator, in its sole discretion and pursuant
to such procedures as it may specify from time to time, may permit Participant to satisfy such Tax Obligations, in whole or in
part (without limitation), if permissible by applicable local law, by (i) paying cash, (ii) electing to have the Company
withhold otherwise deliverable Shares having a fair market value equal to the minimum amount that is necessary to meet the withholding
requirement for such Tax Obligations (or such greater amount as Participant may elect if permitted by the Administrator, if such
greater amount would not result in adverse financial accounting consequences), (iii) having the amount of such Tax Obligations
withheld from Participant’s wages or other cash compensation paid to Participant by the applicable Service Recipient(s),
(iv) delivering to the Company Shares that Participant owns and that have vested with a fair market value equal to such Tax
Obligations, or (v) selling a sufficient number of such Shares otherwise deliverable to Participant through such means as
the Company may determine in its sole discretion (whether through a broker or otherwise) equal to the minimum amount that is necessary
to meet the withholding requirement for such Tax Obligations (or such greater amount as Participant may elect if permitted by the
Administrator, if such greater amount would not result in adverse financial accounting consequences). To the extent determined
appropriate by the Administrator in its discretion, the Administrator will have the right (but not the obligation) to satisfy any
Tax Obligations by reducing the number of Shares otherwise deliverable to Participant.


 






    	 	-3-	 



     


    

 


(c)            Notice
of Disqualifying Disposition of ISO Shares. If the Option granted to Participant herein is an ISO, and if Participant sells
or otherwise disposes of any of the Shares acquired pursuant to the ISO on or before the later of (i) the date two (2) years
after the Date of Grant, or (ii) the date one (1) year after the date of exercise, Participant shall immediately notify
the Company in writing of such disposition. Participant agrees that Participant may be subject to income tax withholding by the
Company on the compensation income recognized by Participant.


 


(d)            Section 409A.
Under Section 409A, a stock right (such as the Option) that vests after December 31, 2004 (or that vested on or prior
to such date but which was materially modified after October 3, 2004), that was granted with a per share exercise price that
is determined by the Internal Revenue Service (the “IRS”) to be less than the fair market value of an underlying
share on the date of grant (a “discount option”) may be considered “deferred compensation.” A stock
right that is a “discount option” may result in (i) income recognition by the recipient of the stock right prior
to the exercise of the stock right, (ii) an additional twenty percent (20%) federal income tax, and (iii) potential penalty
and interest charges. The “discount option” may also result in additional state income, penalty and interest tax to
the recipient of the stock right. Participant acknowledges that the Company cannot and has not guaranteed that the IRS will agree
that the per Share exercise price of this Option equals or exceeds the fair market value of a Share on the date of grant in a later
examination. Participant agrees that if the IRS determines that the Option was granted with a per Share exercise price that was
less than the fair market value of a Share on the date of grant, Participant shall be solely responsible for Participant’s
costs related to such a determination. In no event will the Company or any of its Parent or Subsidiaries have any responsibility,
liability, or obligation to reimburse, indemnify, or hold harmless Participant (or any other person) in respect of this Option
or any other Awards, for any taxes, penalties or interest that may be imposed on, or other costs incurred by, Participant (or any
other person) as a result of Section 409A.


 


9.            Rights
as Stockholder. Neither Participant nor any person claiming under or through Participant will have any of the rights or privileges
of a stockholder of the Company in respect of any Shares deliverable hereunder unless and until certificates representing such
Shares (which may be in book entry form) will have been issued, recorded on the records of the Company or its transfer agents or
registrars, and delivered to Participant (including through electronic delivery to a brokerage account). After such issuance, recordation
and delivery, Participant will have all the rights of a stockholder of the Company with respect to voting such Shares and receipt
of dividends and distributions on such Shares.


 


10.            Entire
Agreement; Governing Law. The Plan is incorporated herein by reference. The Plan and this Option Agreement constitute the entire
agreement of the parties with respect to the subject matter hereof and supersede in their entirety all prior undertakings and agreements
of the Company and Participant with respect to the subject matter hereof, and may not be modified adversely to Participant’s
interest except by means of a writing signed by the Company and Participant. This Option Agreement is governed by the internal
substantive laws but not the choice of law rules of the State of Colorado.


 






    	 	-4-	 



     


    

 


11.           No
Guarantee of Continued Service. PARTICIPANT ACKNOWLEDGES AND AGREES THAT THE VESTING OF SHARES PURSUANT TO THE VESTING SCHEDULE
HEREOF IS EARNED ONLY BY CONTINUING AS A SERVICE PROVIDER, WHICH UNLESS PROVIDED OTHERWISE UNDER APPLICABLE LAWS IS AT THE WILL
OF THE COMPANY (OR THE PARENT OR SUBSIDIARY EMPLOYING OR RETAINING PARTICIPANT) AND NOT THROUGH THE ACT OF BEING HIRED, BEING GRANTED
THIS OPTION OR ACQUIRING SHARES HEREUNDER. PARTICIPANT FURTHER ACKNOWLEDGES AND AGREES THAT THIS OPTION AGREEMENT, THE TRANSACTIONS
CONTEMPLATED HEREUNDER AND THE VESTING SCHEDULE SET FORTH HEREIN DO NOT CONSTITUTE AN EXPRESS OR IMPLIED PROMISE OF CONTINUED ENGAGEMENT
AS A SERVICE PROVIDER FOR THE VESTING PERIOD, FOR ANY PERIOD, OR AT ALL, AND SHALL NOT INTERFERE IN ANY WAY WITH PARTICIPANT’S
RIGHT OR THE RIGHT OF THE COMPANY (OR THE PARENT OR SUBSIDIARY EMPLOYING OR RETAINING PARTICIPANT) TO TERMINATE PARTICIPANT’S
RELATIONSHIP AS A SERVICE PROVIDER, SUBJECT TO APPLICABLE LAW, WHICH TERMINATION, UNLESS PROVIDED OTHERWISE UNDER APPLICABLE LAW,
MAY BE AT ANY TIME, WITH OR WITHOUT CAUSE.


 


12.           Nature
of Grant. In accepting the Option, Participant acknowledges, understands and agrees that:


 


(a)            the
grant of the Option is voluntary and occasional and does not create any contractual or other right to receive future grants of
options, or benefits in lieu of options, even if options have been granted in the past;


 


(b)            all
decisions with respect to future option or other grants, if any, will be at the sole discretion of the Administrator;


 


(c)            Participant
is voluntarily participating in the Plan;


 


(d)            the
Option and any Shares acquired under the Plan are not intended to replace any pension rights or compensation;


 


(e)            the
Option and Shares acquired under the Plan and the income and value of same, are not part of normal or expected compensation for
purposes of calculating any severance, resignation, termination, redundancy, dismissal, end-of-service payments, bonuses, long-service
awards, pension or retirement or welfare benefits or similar payments;


 


(f)            the
future value of the Shares underlying the Option is unknown, indeterminable, and cannot be predicted with certainty;


 


(g)            if
the underlying Shares do not increase in value, the Option will have no value;


 






    	 	-5-	 



     


    




 


(h)          if
Participant exercises the Option and acquires Shares, the value of such Shares may increase or decrease in value, even below the
Exercise Price;


 


(i)            for
purposes of the Option, Participant’s status as a Service Provider will be considered terminated as of the date Participant
is no longer actively providing services to the Company or any Parent or Subsidiary (regardless of the reason for such termination
and whether or not later found to be invalid or in breach of employment laws in the jurisdiction where Participant is a Service
Provider or the terms of Participant’s employment or service agreement, if any), and unless otherwise expressly provided
in this Option Agreement (including by reference in the Notice of Grant to other arrangements or contracts) or determined by the
Administrator, (i) Participant’s right to vest in the Option under the Plan, if any, will terminate as of such date
and will not be extended by any notice period (e.g., Participant’s period of service would not include any contractual notice
period or any period of “garden leave” or similar period mandated under employment laws in the jurisdiction where Participant
is a Service Provider or the terms of Participant’s employment or service agreement, if any, unless Participant is providing
bona fide services during such time); and (ii) the period (if any) during which Participant may exercise the Option after
such termination of Participant’s engagement as a Service Provider will commence on the date Participant ceases to actively
provide services and will not be extended by any notice period mandated under employment laws in the jurisdiction where Participant
is employed or terms of Participant’s engagement agreement, if any; the Administrator shall have the exclusive discretion
to determine when Participant is no longer actively providing services for purposes of this Option grant (including whether Participant
may still be considered to be providing services while on a leave of absence and consistent with local law);


 


(j)            unless
otherwise provided in the Plan or by the Administrator in its discretion, the Option and the benefits evidenced by this Option
Agreement do not create any entitlement to have the Option or any such benefits transferred to, or assumed by, another company
nor be exchanged, cashed out or substituted for, in connection with any corporate transaction affecting the Shares; and


 


(k)           the
following provisions apply only if Participant is providing services outside the United States:


 


(i)            the
Option and the Shares subject to the Option are not part of normal or expected compensation or salary for any purpose;


 


(ii)            Participant
acknowledges and agrees that no Service Recipient shall be liable for any foreign exchange rate fluctuation between Participant’s
local currency and the United States Dollar that may affect the value of the Option or of any amounts due to Participant pursuant
to the exercise of the Option or the subsequent sale of any Shares acquired upon exercise; and


 


(iii)           no
claim or entitlement to compensation or damages shall arise from forfeiture of the Option resulting from the termination of Participant’s
status as a Service Provider (for any reason whatsoever, whether or not later found to be invalid or in breach of employment laws
in the jurisdiction where Participant is a Service Provider or the terms of Participant’s employment or service agreement,
if any), and in consideration of the grant of the Option to which Participant is otherwise not entitled, Participant irrevocably
agrees never to institute any claim against any Service Recipient, waives his or her ability, if any, to bring any such claim,
and releases each Service Recipient from any such claim; if, notwithstanding the foregoing, any such claim is allowed by a court
of competent jurisdiction, then, by participating in the Plan, Participant shall be deemed irrevocably to have agreed not to pursue
such claim and agrees to execute any and all documents necessary to request dismissal or withdrawal of such claim.


 






    	 	-6-	 



     


    

 


13.            No
Advice Regarding Grant. The Company is not providing any tax, legal or financial advice, nor is the Company making any recommendations
regarding Participant’s participation in the Plan, or Participant’s acquisition or sale of the Shares underlying the
Option. Participant is hereby advised to consult with his or her own personal tax, legal and financial advisers regarding his or
her participation in the Plan before taking any action related to the Plan.


 


14.            Data
Privacy. Participant hereby explicitly and unambiguously consents to the collection, use and transfer, in electronic
or other form, of Participant’s personal data as described in this Option Agreement and any other Option grant materials
by and among, as applicable, the Service Recipients for the exclusive purpose of implementing, administering and managing Participant’s
participation in the Plan.


 


Participant understands
that the Company and the Service Recipient may hold certain personal information about Participant, including, but not limited
to, Participant’s name, home address and telephone number, date of birth, social insurance number or other identification
number, salary, nationality, job title, any Shares or directorships held in the Company, details of all Options or any other entitlement
to Shares awarded, canceled, exercised, vested, unvested or outstanding in Participant’s favor (“Data”),
for the exclusive purpose of implementing, administering and managing the Plan.


 


Participant understands
that Data may be transferred to a stock plan service provider, as may be selected by the Company in the future, assisting the Company
with the implementation, administration and management of the Plan. Participant understands that the recipients of the Data may
be located in the United States or elsewhere, and that the recipients’ country of operation (e.g., the United States) may
have different data privacy laws and protections than Participant’s country. Participant understands that if he or she resides
outside the United States, he or she may request a list with the names and addresses of any potential recipients of the Data by
contacting his or her local human resources representative. Participant authorizes the Company, any stock plan service provider
selected by the Company and any other possible recipients which may assist the Company (presently or in the future) with implementing,
administering and managing the Plan to receive, possess, use, retain and transfer the Data, in electronic or other form, for the
sole purpose of implementing, administering and managing his or her participation in the Plan. Participant understands that Data
will be held only as long as is necessary to implement, administer and manage Participant’s participation in the Plan. Participant
understands if he or she resides outside the United States, he or she may, at any time, view Data, request additional information
about the storage and processing of Data, require any necessary amendments to Data or refuse or withdraw the consents herein, in
any case without cost, by contacting in writing his or her local human resources representative. Further, Participant understands
that he or she is providing the consents herein on a purely voluntary basis. If Participant does not consent, or if Participant
later seeks to revoke his or her consent, his or her status as a Service Provider and career with the Service Recipient will not
be adversely affected. The only adverse consequence of refusing or withdrawing Participant’s consent is that the Company
would not be able to grant Participant Options or other equity awards or administer or maintain such awards. Therefore, Participant
understands that refusing or withdrawing his or her consent may affect Participant’s ability to participate in the Plan.
For more information on the consequences of Participant’s refusal to consent or withdrawal of consent, Participant understands
that he or she may contact his or her local human resources representative.


 






    	 	-7-	 



     


    

 


15.            Address
for Notices. Any notice to be given to the Company under the terms of this Option Agreement will be addressed to the Company
at Edgewise Therapeutics, Inc., 3415 Colorado Ave, Boulder, Colorado 80303, or at such other address as the Company may hereafter
designate in writing.


 


16.            Successors
and Assigns. The Company may assign any of its rights under this Option Agreement to single or multiple assignees, and this
Option Agreement shall inure to the benefit of the successors and assigns of the Company. Subject to the restriction on transfer
herein set forth, this Option Agreement shall be binding upon the executors, administrators, heirs, successors and assigns of Participant.
The rights and obligations of Participant under this Option Agreement may be assigned only with the prior written consent of the
Company.


 


17.            Additional
Conditions to Issuance of Stock. If at any time the Company will determine, in its discretion, that the listing, registration,
qualification or rule compliance of the Shares upon any securities exchange or under any state, federal or non-U.S. law, the
tax code and related regulations or under the rulings or regulations of the U.S. Securities and Exchange Commission or any other
governmental regulatory body or the clearance, consent or approval of the U.S. Securities and Exchange Commission or any other
governmental regulatory authority is necessary or desirable as a condition to the exercise of the Options or the purchase by, or
issuance of Shares, to Participant (or his or her estate) hereunder, such exercise, purchase or issuance will not occur unless
and until such listing, registration, qualification, rule compliance, clearance, consent or approval will have been completed,
effected or obtained free of any conditions not acceptable to the Company. Subject to the terms of the Option Agreement and the
Plan, the Company will not be required to issue any certificate or certificates for (or make any entry on the books of the Company
or of a duly authorized transfer agent of the Company of) the Shares hereunder prior to the lapse of such reasonable period of
time following the date of exercise of the Option as the Administrator may establish from time to time for reasons of administrative
convenience.


 


18.            Language.
If Participant has received this Option Agreement or any other document related to the Plan translated into a language other than
English and if the meaning of the translated version is different than the English version, the English version will control.


 


19.            Interpretation.
The Administrator will have the power to interpret the Plan and this Option Agreement and to adopt such rules for the administration,
interpretation and application of the Plan as are consistent therewith and to interpret or revoke any such rules (including,
but not limited to, the determination of whether or not any Shares subject to the Option have vested). All actions taken and all
interpretations and determinations made by the Administrator in good faith will be final and binding upon Participant, the Company
and all other interested persons. Neither the Administrator nor any person acting on behalf of the Administrator will be personally
liable for any action, determination or interpretation made in good faith with respect to the Plan or this Option Agreement.


 






    	 	-8-	 



     


    

 


20.            Electronic
Delivery and Acceptance. The Company may, in its sole discretion, decide to deliver any documents related to the Option awarded
under the Plan or future options that may be awarded under the Plan by electronic means or require Participant to participate in
the Plan by electronic means. Participant hereby consents to receive such documents by electronic delivery and agrees to participate
in the Plan through any on-line or electronic system established and maintained by the Company or a third party designated by the
Company.


 


21.            Captions.
Captions provided herein are for convenience only and are not to serve as a basis for interpretation or construction of this Option
Agreement.


 


22.            Option
Agreement Severable. In the event that any provision in this Option Agreement will be held invalid or unenforceable, such provision
will be severable from, and such invalidity or unenforceability will not be construed to have any effect on, the remaining provisions
of this Option Agreement.


 


23.            Amendment,
Suspension or Termination of the Plan. By accepting this Option, Participant expressly warrants that he or she has received
an Option under the Plan, and has received, read and understood a description of the Plan. Participant understands that the Plan
is discretionary in nature and may be amended, suspended or terminated by the Administrator at any time.


 


24.            Country
Addendum. Notwithstanding any provisions in this Option Agreement, this Option shall be subject to any special terms and conditions
set forth in an appendix (if any) to this Option Agreement for any country whose laws are applicable to Participant and this Option
(as determined by the Administrator in its sole discretion) (the “Country Addendum”). Moreover, if Participant
relocates to one of the countries included in the Country Addendum (if any), the special terms and conditions for such country
will apply to Participant, to the extent the Company determines that the application of such terms and conditions is necessary
or advisable for legal or administrative reasons. The Country Addendum (if any) constitutes a part of this Option Agreement.


 


25.            Modifications
to the Option Agreement. This Option Agreement constitutes the entire understanding of the parties on the subjects covered.
Participant expressly warrants that he or she is not accepting this Option Agreement in reliance on any promises, representations,
or inducements other than those contained herein. Modifications to this Option Agreement or the Plan can be made only in an express
written contract executed by a duly authorized officer of the Company. Notwithstanding anything to the contrary in the Plan or
this Option Agreement, the Company reserves the right to revise this Option Agreement as it deems necessary or advisable, in its
sole discretion and without the consent of Participant, to comply with Code Section 409A or to otherwise avoid imposition
of any additional tax or income recognition under Section 409A of the Code in connection with the Option.


 






    	 	-9-	 



     


    

 


26.            No
Waiver. Either party’s failure to enforce any provision or provisions of this Option Agreement shall not in any way be
construed as a waiver of any such provision or provisions, nor prevent that party from thereafter enforcing each and every other
provision of this Option Agreement. The rights granted both parties herein are cumulative and shall not constitute a waiver of
either party’s right to assert all other legal remedies available to it under the circumstances.


 


27.            Tax
Consequences. Participant has reviewed with his or her own tax advisers the U.S. federal, state, local and non-U.S. tax consequences
of this investment and the transactions contemplated by this Option Agreement. With respect to such matters, Participant relies
solely on such advisers and not on any statements or representations of the Company or any of its agents, written or oral. Participant
understands that Participant (and not the Company) shall be responsible for Participant’s own tax liability that may arise
as a result of this investment or the transactions contemplated by this Option Agreement.


 


*          *          *


 






    	 	-10-	 



     


    







 


EXHIBIT B


 


EDGEWISE THERAPEUTICS, INC.


 


2021
EQUITY INCENTIVE PLAN


 


STOCK OPTION AGREEMENT


 


EXERCISE NOTICE


 


Edgewise Therapeutics, Inc. 


3415 Colorado Ave, 


Boulder, Colorado 80303 


Attention: Stock Administration


 


1.            Exercise
of Option. Effective as of today, ________________, ____, the undersigned (“Participant”) hereby elects
to exercise Participant’s option (the “Option”) to purchase ________________ shares of the Common
Stock (the “Shares”) of Edgewise Therapeutics, Inc. (the “Company”) under and pursuant to the
2021 Equity Incentive Plan (the “Plan”) and the Stock Option Agreement dated ______________, _____, including
the Notice of Stock Option Grant, and the Terms and Conditions of Stock Option Grant attached as Exhibit A thereto
and other exhibits, appendices and addenda attached thereto (the “Option Agreement”). Unless otherwise defined
herein, capitalized terms used in this Exercise Notice will be ascribed the same defined meanings as set forth in the Option Agreement
(or the Plan or other written agreement as specified in the Option Agreement).


 


2.            Delivery
of Payment. Participant herewith delivers to the Company the full purchase price of the Shares, as set forth in the Option
Agreement, and any Tax Obligations to be paid in connection with the exercise of the Option.


 


3.            Representations
of Participant. Participant acknowledges that Participant has received, read and understood the Plan and the Option Agreement
and agrees to abide by and be bound by their terms and conditions.


 


4.            Rights
as Stockholder. Until the issuance of the Shares (as evidenced by the appropriate entry on the books of the Company or of a
duly authorized transfer agent of the Company), no right to vote or receive dividends or any other rights as a stockholder shall
exist with respect to the Common Stock subject to the Option, notwithstanding the exercise of the Option. The Shares so acquired
shall be issued to Participant as soon as practicable after the Option is exercised in accordance with the Option Agreement. No
adjustment shall be made for a dividend or other right for which the record date is prior to the date of issuance except as provided
in Section 14 of the Plan.


 


5.            Tax
Consultation. Participant understands that Participant may suffer adverse tax consequences as a result of Participant’s
purchase or disposition of the Shares. Participant represents that Participant has consulted with any tax consultants Participant
deems advisable in connection with the purchase or disposition of the Shares and that Participant is not relying on the Company
for any tax advice.


 






     

     


    

 


6.            Interpretation.
Any dispute regarding the interpretation of this Exercise Notice shall be submitted by Participant or by the Company forthwith
to the Administrator, which shall review such dispute at its next regular meeting. The resolution of such a dispute by the Administrator
shall be final and binding on all parties to the maximum extent permitted by law.


 


7.            Governing
Law; Severability. This Exercise Notice is governed by the internal substantive laws, but not the choice of law rules, of Colorado.
In the event that any provision hereof becomes or is declared by a court of competent jurisdiction to be illegal, unenforceable
or void, this Exercise Notice shall continue in full force and effect.


 


8.            Entire
Agreement. The Plan and Option Agreement are incorporated herein by reference. The Plan and the Option Agreement (including
this Exercise Notice and any exhibits, appendices, and addenda attached to the Notice of Stock Option Grant of the Option Agreement)
constitute the entire agreement of the parties with respect to the subject matter hereof and supersede in their entirety all prior
undertakings and agreements of the Company and Participant with respect to the subject matter hereof, and may not be modified adversely
to Participant’s interest except by means of a writing signed by the Company and Participant.


 


	Submitted by:	 	Accepted by:
	PARTICIPANT	 	EDGEWISE
THERAPEUTICS, INC.
	 	 	 
	 	 	 
	Signature	 	By
	 	 	 
	Print Name	 	Print Name
	 	 	 
	 	 	Title
	 	 	 
	Address:	 	Address:
	 	 	 
	 	 	 
	 	 	 
	 	 	Date Received




 






    	 	-2-	 



     


    

 


APPENDIX A


 


EDGEWISE THERAPEUTICS, INC.


 


2021
EQUITY INCENTIVE PLAN


 


COUNTRY ADDENDUM TO STOCK OPTION AGREEMENT


 


Unless otherwise defined
herein, capitalized terms used in this Country Addendum to Stock Option Agreement (the “Country Addendum”) will
be ascribed the same defined meanings as set forth in the Option Agreement of which this Country Addendum forms a part (or the
Plan or other written agreement as specified in the Option Agreement).


 


Terms and Conditions


 


This Country Addendum
includes additional terms and conditions that govern this Option awarded to Participant under the Plan if he or she resides and/or
works in one of the countries listed below. If Participant is a citizen or resident (or is considered as such for local law purposes)
of a country other than the country in which Participant is currently residing and/or working, or if Participant relocates to another
country after the Options is granted, the Company, in its discretion, shall determine to what extent the terms and conditions contained
herein shall apply to Participant.


 


Notifications


 


This
Country Addendum also may include information regarding exchange controls and certain other issues of which Participant should
be aware with respect to participation in the Plan. The information is based on the securities, exchange control, and other Applicable
Laws in effect in the respective countries as of [______], 2021. Such Applicable Laws often are complex and change frequently.
As a result, the Company strongly recommends that Participant not rely on the information in this Country Addendum as the only
source of information relating to the consequences of Participant’s participation in the Plan because the information may
be out of date at the time Participant vests in or exercises the Option or sells Shares acquired under the Plan.


 


In addition, the information
contained in this Country Addendum is general in nature and may not apply to Participant’s particular situation, and the
Company is not in a position to assure Participant of a particular result. Participant should seek appropriate professional advice
as to how the Applicable Laws in Participant’s country may apply to his or her situation.


 


Finally, if Participant
is a citizen or resident of a country other than the one in which Participant currently is residing and/or working, transfers residence
and/or employment to another country after this Option is awarded, or is considered a resident of another country for local law
purposes, the information in this Country Addendum may not apply to Participant in the same manner.