Global Warming Potential 

3-ethoxy-1,1,1,2,3,4,4,5,5,6,6,6-dodecafluoro-2-trifluoromethyl-hexane 

(HFE-7500) (CAS Number: 297730-93-9)

Summary: 

This document describes analysis conducted by 3M to determine a Global Warming Potential 

(GWP) for HFE-7500. The format of this report is consistent with submittals to EPA for the 

use of Provisional GWPs. The Mandatory Reporting Rule requires facilities to monitor and 

report CO2-equivalent F-GHG process vent emissions, if those emissions exceed a threshold 

of 10,000 metric tons CO2-equivalent per year. [1] Estimated CO2-equivalent emissions are 

obtained by multiplying the F-GHG mass emissions by the Global Warming Potential (GWP) 

for the individual fluorinated gases that comprise the flow. EPA has provided a table of 100-

year time horizon GWP values for about 70 individual F-GHG, and specifies that these 

values are to be used for the purpose of computing CO2-equivalent emissions. [2] Default 

GWPs can be used for any fluorinated-GHG not listed in Table A-1. The regulation allows a 

facility to request a lower provisional GWP when clear scientific evidence exists to support 

such a lower value. 

Table A–1 does not list a GWP for 3-ethoxy-1,1,1,2,3,4,4,5,5,6,6,6-dodecafluoro-2-

trifluoromethyl-hexane (HFE-7500). As described in greater detail in a subsequent section, 

the atmospheric lifetime of 3-ethoxy-1,1,1,2,3,4,4,5,5,6,6,6-dodecafluoro-2-trifluoromethylhexane has been determined to be 2.2 years based upon laboratory measurements; the 

radiative forcing of 3-ethoxy-1,1,1,2,3,4,4,5,5,6,6,6-dodecafluoro-2-trifluoromethyl-hexane 

has been measured using a quantitative infrared spectrum and the GWP of 3-ethoxy1,1,1,2,3,4,4,5,5,6,6,6-dodecafluoro-2-trifluoromethyl-hexane has been calculated as 100 

relative to CO2 with a 100-year integration time horizon. 

Evidence Supporting Estimated GWP: 

F-GHG Identity: 3-ethoxy-1,1,1,2,3,4,4,5,5,6,6,6-dodecafluoro-2-trifluoromethyl-hexane 

(HFE-7500) 

Chemical Formula: CF3CF2CF2CF(OC2H5)CF(CF3)2

CAS Number: 297730-93-9 

Estimated GWP: 100 relative to CO2 with a 100-year integration time horizon 

Data and analysis: Goto et al. have measured kinetic rate constants for the vapor phase 

reaction of 3-ethoxy-1,1,1,2,3,4,4,5,5,6,6,6-dodecafluoro-2-trifluoromethyl-hexane with OH 

using a relative rate technique, resulting in an atmospheric lifetime calculated at 2.2 years [3]. 

Goto et al. measured quantitative infrared spectra for 3-ethoxy-1,1,1,2,3,4,4,5,5,6,6,6- 

dodecafluoro-2-trifluoromethyl-hexane. An FTIR spectrum for this compound is provided in 

Figure 1. The instantaneous forcing was calculated using the approximation method 

developed by Pinnock et al. [4] as 0.37 Wm-2ppbv-1. This calculation assumes that there is a 

constant concentration profile of the compound at all altitudes. To correct for this, the value 

was multiplied by a scaling factor as suggested by Sihra et al. [5] to account for the uneven 

vertical distribution of this compound in the atmosphere, resulting in a final radiative forcing 

value of 0.30 Wm-2ppbv-1

. 
Using these data in the equation referenced by the IPCC [6] to determine the GWP of a given 

substance, a GWP of 100 relative to CO2 with a 100-year integration time horizon was 

established. 

1. "Mandatory Reporting of Greenhouse Gases: Additional Sources of Fluorinated GHGs; 

Final Rule", Federal Register 75:230 (December 1, 2010) p.74774. 

2. "Table A-1 to Subpart A of Part 98—Global Warming Potentials": Table A-1 in 40 CFR 

part 98, subpart A. 

3. Goto, M., Inque, Y., Kawasaski, M., Guschin, A.G., Molina, L.T., Molina, M.J., 

Wallington, T.J., and Hurley, M.D., Environ. Sci. Technol., 36, 2395-2402, 2002. 

4. Pinnock, S., et al., Radiative forcing of climate by hydrochlorofluorocarbons and 

hydrofluorocarbons. Journal of Geophysical Research, 1995. 100 (D11): p. 23227-23238. 

5. Sihra, K., et al., Updated radiative forcing estimates of 65 halocarbons and nonmethane 

hydrocarbons, Journal of Geophysical Research, 2001. 106 (D17): p. 20493-20505. 

6. IPCC, 2007: Climate Change 2007: Impacts, Adaptation and Vulnerability. Contribution 

of Working Group II to the Fourth Assessment. Report of the Intergovernmental Panel on 

Climate Change, M.L. Parry, O.F. Canziani, J.P. Palutikof, P.J. van der Linden and C.E. 

Hanson, Eds., Cambridge University Press, Cambridge, UK, 976pp.
Figure 1. FTIR Reference Spectrum of HFE-7500 

0

.1

.2

.3

.4

 4500 4000 3500 3000 2500 2000 1500 1000 

Absorbance / Wavenumber (cm-1) Paged X-Zoom CURSOR

File # 3 : 58_HFE7500 3/6/2001 3:54 PM Res=None

HFE-7500, 58.45 ppm_m, 5.62 ppm, 24C, 10.4m, (10.0 ppm dilute withN2, Quant vs. 104_HFE7500), inst. O, blc.& H20 subtracted