Exhibit 10.18  Level 2  Amended & Restated  PONIARD
PHARMACEUTICALS, INC.
AMENDED AND RESTATED
KEY EXECUTIVE SEVERANCE AGREEMENT  This Amended and Restated Key Executive Severance Agreement (this Agreement), dated as
of February 24, 2009, is entered into by and between PONIARD
PHARMACEUTICALS, INC., a Washington corporation (as supplemented by Section 10
hereof, the Company),
and ROBERT L. DE JAGER (the Executive) to reflect amendments made in December,
2008.  The Board of Directors of the Company (the Board) has
determined that it is in the best interests of the Company and its shareholders
to ensure that the Company will have the continued dedication of the Executive,
notwithstanding the fact that the Executive does not have any form of
traditional employment contract or other assurance of job security.  The Board believes it is imperative to
diminish any distraction of the Executive arising from the personal uncertainty
and insecurity that arises in the absence of any assurance of job security by providing
the Executive with reasonable compensation and benefit arrangements in the
event of termination of the Executives employment by the Company under certain
defined circumstances.  In order to accomplish these objectives, the Board has caused the Company
to enter into this Agreement.  1.Term  The initial
term of this Agreement (the Initial Term)
shall be for a period of one (1) year from the date of this Agreement as first
appearing above; provided, however, that this Agreement shall automatically
renew for successive additional one (1) year periods (Renewal
Terms) unless notice of nonrenewal is given by either party to
the other party at least nine (9) months prior to the end of the Initial Term
or any Renewal Term; and provided, further, that if a Change of Control (as
defined in the Change of Control Agreement referenced in Section 16 hereof)
occurs during the Term, the Term shall automatically extend for the duration of
the Employment Period (as defined in the Change of Control Agreement).  The Term of
this Agreement shall be the Initial Term plus all Renewal Terms and, if
applicable, the duration of the Employment Period.  At the end of the Term, this Agreement shall
terminate without further action by either the Company or the Executive.  2.Employment
at Will  The Executive and the Company acknowledge that, except as may otherwise
be provided under any other written agreement between the Executive and the
Company, the employment of the Executive by the Company or any affiliated
companies is at will and may be terminated by either the Executive or the
Company or its affiliated companies at any time with or without cause, subject
to the termination payments prescribed herein.


3.Attention
and Effort  During any period of time that the Executive remains in the employ of
the Company, and excluding any periods of vacation and sick leave to which the
Executive is entitled, the Executive will devote all of the Executives
productive time, ability, attention and effort to the business and affairs of
the Company and the discharge of the responsibilities assigned to the Executive
hereunder, and will seek to perform faithfully and efficiently such
responsibilities.  It shall not be a
violation of this Agreement for the Executive to (a) serve on corporate,
civic or charitable boards or committees, (b) deliver lectures, fulfill
speaking engagements or teach at educational institutions, (c) manage
personal investments, or (d) engage in activities permitted by the
policies of the Company or as specifically permitted by the Company, so long as
such activities do not significantly interfere with the performance of the
Executives responsibilities in accordance with this Agreement.  It is expressly understood and agreed that to
the extent any such activities have been conducted by the Executive prior to
the Term, the continued conduct of such activities (or the conduct of
activities similar in nature and scope thereto) during the Term shall not
thereafter be deemed to interfere with the performance of the Executives
responsibilities to the Company.  4.Termination  During the Term, employment of the Executive may be terminated as
follows, but, in any case, the nondisclosure provisions set forth in Section 7
hereof shall survive the termination of this Agreement and the termination of
the Executives employment with the Company:  4.1          Termination by the Company or the
Executive  At any time during the Term, the Company may terminate the employment
of the Executive with or without Cause (as defined below), and the Executive
may terminate the Executives employment for Good Reason (as defined below) or
for any reason, upon giving a Notice of Termination (as defined below).  4.2          Automatic Termination  This Agreement and the Executives employment during the Term shall
terminate automatically upon the death or Total Disability of the
Executive.  The term Total Disability as
used herein shall mean the Executives inability (with such accommodation as
may be required by law and which places no undue burden on the Company), as
determined by a physician selected by the Company and acceptable to the
Executive, to perform the Executives essential duties for a period or periods
aggregating twelve (12) weeks in any three hundred sixty-five (365) day period
as a result of physical or mental illness, loss of legal capacity or any other
cause beyond the Executives control, unless the Executive is granted a leave
of absence by the Board.  4.3          Notice of Termination  Any termination by the Company or by the Executive during the Term
shall be communicated by a Notice of Termination to the other party given in
accordance with Section 9 hereof. 
The term Notice
of Termination shall mean a written notice that (a) indicates
the specific termination provision in this Agreement relied upon and (b) to
the extent applicable, sets  2


forth in reasonable detail the facts and
circumstances claimed to provide a basis for termination of the Executives
employment under the provision so indicated. 
The failure by the Executive or the Company to set forth in the Notice
of Termination any fact or circumstance that contributes to a showing of Good
Reason or Cause shall not waive any right of the Executive or the Company
hereunder or preclude the Executive or the Company from asserting such fact or
circumstance in enforcing the Executives or the Companys rights hereunder.  4.4          Date of Termination  Date of
Termination means (a) if the Executives employment is
terminated by reason of death, the last day of the calendar month in which the
Executives death occurs, (b) if the Executives employment is terminated
by reason of Total Disability, immediately upon a determination by the
Company of the Executives Total Disability, and (c) in all other cases,
ten (10) days after the date of personal delivery or mailing of the Notice
of Termination.  The Executives
employment and performance of services will continue during such ten (10) day
period; provided, however, that the Company may, upon notice to the Executive
and without reducing the Executives compensation during such period, excuse
the Executive from any or all of the Executives duties during such
period.  Notwithstanding anything contained in this Agreement to the contrary, the
date on which a separation from service (Separation from Service)
pursuant to Section 409A of the Internal Revenue Code of 1986, as amended
(Code Section 409A), occurs shall be the Date of Termination or termination
of employment for purposes of determining the timing of payments under this
Agreement to the extent necessary to have such payments and benefits under this
Agreement be exempt from the requirements of Code Section 409A or comply
with the requirements of Code Section 409A.  5.Termination
Payments  In the event of termination of the Executives employment during the
Term, all compensation and benefits shall terminate, except as specifically
provided in this Section 5.  5.1Termination
by the Company Other Than for Cause or by the Executive for Good Reason  If during the Term the Company terminates the Executives employment
other than for Cause or the Executive terminates the Executives employment for
Good Reason, the Executive shall be entitled to:  (a)receive
payment of the following accrued obligations (the Accrued Obligations):  (i)            the Executives
then current annual base salary through the Date of Termination to the extent
not theretofore paid;  (ii)           any compensation
previously deferred by the Executive (together with accrued interest or earnings
thereon, if any); and  (iii)          any accrued
vacation pay that would be payable under the Companys standard policy, in each
case to the extent not theretofore paid;  3


(b)           have the Company pay
for nine (9) months after the Date of Termination or until the Executive
qualifies for comparable medical and dental insurance benefits from another
employer, whichever occurs first, the Executives premiums for health insurance
benefit continuation for the Executive and the Executives family members, if
applicable, that the Company provides to the Executive under the provisions of
the federal Consolidated Omnibus Budget Reconciliation Act of 1985, as amended
(COBRA),
to the extent that the Company would have paid such premiums had the Executive
remained employed by the Company (such continued payment is hereinafter
referred to as COBRA
Continuation); and  (c)           an amount as
severance pay equal to seventy-five percent (75%) of the Executives then
current annual base salary for the fiscal year in which the Date of Termination
occurs, subject to payment as set forth in Sections 5.5 and 5.9 hereof.  5.2          Termination for Cause or Other Than
for Good Reason  If during the Term the Executives employment shall be terminated by
the Company for Cause or by the Executive for other than Good Reason, this
Agreement shall terminate without further obligation on the part of the Company
to the Executive, other than the Companys obligation to pay the Executive the
Accrued Obligations to the extent theretofore unpaid.  5.3          Expiration of Term  In the event the Executives employment is not terminated prior to
expiration of the Term, this Agreement shall terminate without further
obligation on the part of the Company to the Executive.  5.4          Termination Because of Death or Total
Disability  If during the Term the Executives employment is terminated by reason
of the Executives death or Total Disability, this Agreement shall terminate
automatically without further obligation on the part of the Company to the
Executive or the Executives legal representatives under this Agreement, other
than the Companys obligation to pay the Executive the Accrued Obligations
(which shall be paid to the Executives estate or beneficiary, as applicable in
the case of the Executives death) and to provide COBRA Continuation.  5.5          Payment Schedule  All payments of Accrued Obligations, or any portion thereof payable
pursuant to this Section 5, other than deferred compensation pursuant to Section 5.1(a)(ii) hereof,
shall be made to the Executive within ten (10) working days of the Date of
Termination.  Deferred compensation
pursuant to Section 5.1(a)(ii) hereof shall be payable pursuant to
the terms of the deferred compensation program. 
Any severance payments payable to the Executive pursuant to Section 5.1(c) hereof
shall be made to the Executive in the form of salary continuation, payable at
normal payroll intervals during the nine (9) month period following the
Date of Termination.  Notwithstanding the
preceding provisions of this Section 5, if any payment or benefit pursuant
to this Agreement constitutes a deferral of compensation subject to Code Section 409A
(after taking into account, to the maximum extent possible, any applicable
exemptions) (a 409A Payment) treated as
payable to a Specified Employee (as defined in Section 20.1 hereof) upon  4


Separation from Service, the provisions of Section 20.1
hereof shall apply.  Section 5.8
hereof must be satisfied to receive payments and benefits under this Agreement.  5.6          Cause  For purposes of this Agreement, Cause means cause given by the Executive to
the Company and shall include, without limitation, the occurrence of one (1) or
more of the following events:  (a)           a clear refusal to
carry out any material lawful duties of the Executive or any directions of the
Board or senior management of the Company reasonably consistent with those
duties;  (b)           persistent failure
to carry out any lawful duties of the Executive or any directions of the Board
or senior management reasonably consistent with those duties; provided,
however, that the Executive has been given reasonable notice and opportunity to
correct any such failure;  (c)           violation by the
Executive of a state or federal criminal law involving the commission of a
crime against the Company or any other criminal act involving moral turpitude;  (d)           current abuse by the
Executive of alcohol or controlled substances; deception, fraud,
misrepresentation or dishonesty by the Executive; or any incident materially
compromising the Executives reputation or ability to represent the Company
with investors, customers or the public; or  (e)           any other material
violation of any provision of this Agreement by the Executive, subject to the
notice and opportunity-to-cure requirements of Section 8 hereof.  5.7          Good Reason  For purposes of this Agreement, Good Reason means:  (a)           material reduction
of the Executives annual base salary to a level below the level in effect on
the date of this Agreement, regardless of any change in the Executives duties
or responsibilities;  (b)           the assignment to
the Executive of any duties materially inconsistent with the Executives
position, authority, duties or responsibilities or any other action by the
Company that results in a material diminution in such position, authority,
duties or responsibilities, excluding for this purpose an isolated and
inadvertent action not taken in bad faith and that is remedied by the Company
promptly after receipt of notice thereof given by the Executive;  (c)           the Companys
requiring the Executive to be based at any office or location more than fifty
(50) miles from the city in which the Executive is currently employed by the
Company, i.e., San Francisco, California or Seattle, Washington;  5


(d)           any failure by the
Company to comply with and satisfy Section 10 hereof; provided, however,
that the Companys successor has received at least ten (10) days prior
written notice from the Company or the Executive of the requirements of Section 10
hereof; or  (e)           any other material
violation of any provision of this Agreement by the Company;  provided,
however, that the Executive has notified the Company of such salary reduction,
assignment, failure, situation or violation within ninety (90) days of its
occurrence and there has been compliance with the notice and
opportunity-to-cure requirements of Section 8 hereof.  5.8          General Release of Claims  As a condition to receiving the payments and benefits under this Section 5
other than Accrued Obligations set forth in Sections 5.1(a)(i) and 5.1(a)(iii) hereof,
the Executive shall execute (and not later revoke) a general release and waiver
of all claims against the Company, which release and waiver shall be in a form
satisfactory to the Company, in its sole discretion, and delivered to the
Company no later than the seventh day of the third month of the fiscal year
following the year in which the Date of Termination occurs.  By way of example and not limitation, the
general release and waiver of claims will include any claims for wages,
bonuses, employment benefits, or damages of any kind whatsoever, arising out of
any contracts, express or implied, any covenant of good faith and fair dealing,
express or implied, any theory of wrongful discharge, any legal restriction on
the Companys right to terminate employment, or any federal, state or other
governmental statute or ordinance, including, without limitation, Title VII of
the Civil Rights Act of 1964, the federal Age Discrimination in Employment Act,
the Americans with Disabilities Act, the Family and Medical Leave Act, the
Washington Law Against Discrimination, or any other legal limitation on the
employment relationship.  To the extent
any payment or benefit is a 409A Payment, the provisions of Section 20.3
hereof shall apply.  5.9          Dispute Regarding Existence of Good
Reason for Termination  In the event the Company disputes whether Good Reason existed for the
Executive to terminate the Executives employment for Good Reason, the Company
shall pay salary continuation as provided in Section 5.5 until the
earliest of (a) settlement by the parties, (b) determination by
arbitration in accordance with Section 14 hereof that Good Reason did not
exist, and (c) completion of the payments required by Section 5.5 and
Section 5.1(c) hereof.  If,
pursuant to Section 14 hereof, an arbitrator determines that Good Reason
did not exist, the arbitrator shall also decide whether the Executive had a
reasonable, good-faith basis for claiming that there was Good Reason to
terminate.  If the arbitrator determines
that there was not such a basis, the Executive shall be obligated to repay
promptly to the Company the salary continuation payments; if the arbitrator
determines that there was such a basis, the Executive shall not be obligated to
repay the salary continuation.  6.Representations,
Warranties and Other Conditions  In order to induce the Company to enter into this Agreement, the
Executive represents and warrants to the Company as follows:  6


6.1          Health  The Executive is in good health and knows of no physical or mental
disability that, with any accommodation that may be required by law and that
places no undue burden on the Company, would prevent the Executive from
fulfilling the Executives obligations hereunder.  The Executive agrees, if the Company
requests, to submit to reasonable periodic medical examinations by a physician
or physicians designated by, paid for and arranged by the Company.  The Executive agrees that each examinations
medical report shall be provided to the Company.  6.2          No Violation of Other Agreements  The Executive represents that neither the execution nor the performance
of this Agreement by the Executive will violate or conflict in any way with any
other agreements or obligations by which the Executive may be bound.  7.Nondisclosure;
Return of Materials  7.1          Nondisclosure  Except as required by the Executives employment with the Company, the
Executive will not, at any time during the term of employment by the Company,
or at any time thereafter, directly, indirectly or otherwise, use, communicate,
disclose, disseminate, lecture upon or publish articles relating to any
confidential, proprietary or trade secret information of the Company without
the prior written consent of the Company. 
The Executive understands that the Company will be relying on this
Agreement in continuing the Executives employment, paying the Executives
compensation, granting the Executive any promotions or raises, or entrusting
the Executive with any information that helps the Company compete with others.  7.2          Return of Materials  All documents, records, notebooks, notes, memoranda, drawings or other
documents made or compiled by the Executive at any time while employed by the
Company, or in the Executives possession, including any and all copies
thereof, shall be the property of the Company and shall be held by the
Executive in trust and solely for the benefit of the Company, and shall be
delivered to the Company by the Executive upon termination of employment or at
any other time upon request by the Company.  8.Notice
and Cure of Breach  Whenever a
breach of this Agreement by either party is relied upon as justification for
any action taken by the other party pursuant to any provision of this
Agreement, other than clause (a), (b), (c) or (d) of Section 5.6
hereof, before such action is taken, the party asserting the breach of this
Agreement shall give the other party at least twenty (20) days prior written
notice of the existence and the nature of such breach before taking further
action hereunder and shall give the party purportedly in breach of this
Agreement the opportunity to correct such breach during the twenty (20) day
period.  7


9.Form of
Notice  Every notice required by the
terms of this Agreement shall be given in writing by serving the same upon the
party to whom it was addressed personally or by registered or certified mail,
return receipt requested, at the address set forth below or at such other
address as may hereafter be designated by notice given in compliance with the
terms hereof:  If to the Executive:
  
  Robert L. De Jager3611 Calle JuegoRancho Santa Fe, CA 92091If to the Company:
  
  Poniard Pharmaceuticals, Inc.300 Elliott Avenue West, Suite 500Seattle, Washington 98119Attn: Chief Executive OfficerWith a copy
  to:
  
  Perkins CoieLLP1201 Third
  Avenue, Suite 4800Seattle,
  Washington 98101-3099Attn: James
  R. Lisbakken  Except as set forth in Section 4.4
hereof, if notice is mailed, such notice shall be effective upon mailing.  10.Assignment  This Agreement is personal to
the Executive and shall not be assignable by the Executive.  The Company shall assign to and
require any successor (whether direct or indirect, by purchase, merger,
consolidation or otherwise) to all or substantially all the business and/or
assets of the Company to assume expressly and agree to perform this Agreement
in the same manner and to the same extent that the Company would be required to
perform it if no such succession had taken place.  As used in this Agreement, Company shall mean
Poniard Pharmaceuticals, Inc. and any affiliated company or successor to
its business and/or assets as aforesaid that assumes and agrees to perform this
Agreement by contract, operation of law or otherwise; and as long as such
successor assumes and agrees to perform this Agreement, the termination of the
Executives employment by one such entity and the immediate hiring and continuation
of the Executives employment by the succeeding entity shall not be deemed to
constitute a termination or trigger any severance obligation under this
Agreement.  All the terms and provisions
of this Agreement shall be binding upon and inure to the benefit of and be
enforceable by the parties hereto and their respective successors and permitted
assigns.  8


11.Waivers  No delay or failure by any
party hereto in exercising, protecting or enforcing any of its rights, titles,
interests or remedies hereunder, and no course of dealing or performance with
respect thereto, shall constitute a waiver thereof.  The express waiver by a party hereto of any
right, title, interest or remedy in a particular instance or circumstance shall
not constitute a waiver thereof in any other instance or circumstance.  All rights and remedies shall be cumulative
and not exclusive of any other rights or remedies.  12.Amendments
in Writing  No amendment, modification,
waiver, termination or discharge of any provision of this Agreement, or consent
to any departure therefrom by either party hereto, shall in any event be
effective unless the same shall be in writing, specifically identifying this
Agreement and the provision intended to be amended, modified, waived,
terminated or discharged and signed by the Company and the Executive, and each
such amendment, modification, waiver, termination or discharge shall be
effective only in the specific instance and for the specific purpose for which
given.  No provision of this Agreement
shall be varied, contradicted or explained by any oral agreement, course of
dealing or performance or any other matter not set forth in an agreement in
writing and signed by the Company and the Executive.  13.Applicable
Law  This Agreement shall in all
respects, including all matters of construction, validity and performance, be
governed by, and construed and enforced in accordance with, the laws of the
State of Washington, without regard to any rules governing conflicts of
laws.  14.Arbitration;
Attorneys Fees  Except in connection with
enforcing Section 7 hereof, for which legal and equitable remedies may be
sought in a court of law, any dispute arising under this Agreement shall be
subject to arbitration.  The arbitration
proceeding shall be conducted in accordance with the Commercial Arbitration Rules of
the American Arbitration Association (the AAA Rules) then in effect, conducted by one (1) arbitrator
either mutually agreed upon or selected in accordance with the AAA Rules.  The arbitration shall be conducted in King
County, Washington, under the jurisdiction of the Seattle office of the
American Arbitration Association.  The arbitrator
shall have authority only to interpret and apply the provisions of this
Agreement, and shall have no authority to add to, subtract from or otherwise
modify the terms of this Agreement.  Any
demand for arbitration must be made within sixty (60) days of the event(s) giving
rise to the claim that this Agreement has been breached.  The arbitrators decision shall be final and
binding, and each party agrees to be bound by the arbitrators award, subject
only to an appeal therefrom in accordance with the laws of the State of
Washington.  Either party may obtain
judgment upon the arbitrators award in the Superior Court of King County,
Washington.  If it becomes necessary to
pursue or defend any legal proceeding, whether in arbitration or court, in
order to resolve a dispute arising under this Agreement, the prevailing party
in any such proceeding shall be entitled to recover its reasonable costs and
attorneys fees.  To the extent necessary
to prevent the Executive from being subject to any additional tax pursuant to  9


Code Section 409A(a)(1)(B),
any amounts payable to the Executive pursuant to this paragraph shall be paid
in no event later than the year following the year during which such costs and
fees were incurred.  15.Severability  If any provision of this
Agreement shall be held invalid, illegal or unenforceable in any jurisdiction,
for any reason, including, without limitation, the duration of such provision,
its geographical scope or the extent of the activities prohibited or required
by it, then, to the full extent permitted by law, (a) all other provisions
hereof shall remain in full force and effect in such jurisdiction and shall be
liberally construed in order to carry out the intent of the parties hereto as
nearly as may be possible, (b) such invalidity, illegality or unenforceability
shall not affect the validity, legality or enforceability of any other
provision hereof, and (c) any court or arbitrator having jurisdiction
thereover shall have the power to reform such provision to the extent necessary
for such provision to be enforceable under applicable law.  16.Coordination
With Change of Control Agreement  Contemporaneously with this
Agreement, the Company and the Executive are entering into an Amended and
Restated Change of Control Agreement (the Change of Control Agreement), which
agreement provides for certain forms of severance and benefit payments in the
event of termination of the Executives employment under certain defined
circumstances.  This Agreement is in
addition to the Change of Control Agreement, providing certain assurances to
the Executive in circumstances that the Change of Control Agreement does not
cover, and in no way supersedes or nullifies the Change of Control
Agreement.  Nevertheless, it is possible
that a termination of employment by the Company or by the Executive may fall
within the scope of both agreements.  In
such event, payments made to the Executive under Section 5.1 hereof shall
be coordinated with payments made to the Executive under Section 8.1 of
the Change of Control Agreement as follows:  (a)           Accrued Obligations under this Agreement need not be paid
if paid under the Change of Control Agreement;  (b)           COBRA Continuation under this Agreement need not be
provided if provided under the Change of Control Agreement; and  (c)           the severance payment required under Section 5.1(c) hereof
(and paid pursuant to Section 5.5 hereof) need not be paid to the extent a
severance payment is made under Section 8.1(d) of the Change of
Control Agreement in connection with a Change of Control under the Change of
Control Agreement that constitutes a change in the ownership or effective
control of the Company or in the ownership of a substantial portion of the
assets of the Company within the meaning of subsection (a)(2)(A)(v) of
Code Section 409A, i.e., the credit from Section 8.1(d) of the
Change of Control Agreement is applied as amounts become due under Section 5.5
hereof.  17.Excess
Parachute Payments  Unless provided by Section 8.8
of the Change of Control Agreement, if any portion of the payments or benefits
under this Agreement or any other agreement or benefit plan of the  10


Company
(including stock options) would be characterized as an excess parachute
payment to the Executive under Section 280G of the Internal Revenue Code
of 1986, as amended (the Code),
the Executive shall be paid any excise tax that the Executive owes under Code Section 4999
as a result of such characterization, such excise tax to be paid to the
Executive at least ten (10) days prior to the date that the Executive is
obligated to make the excise tax payment. 
The determination of whether and to what extent any payments or benefits
would be excess parachute payments and the date by which any excise tax shall
be due shall be determined in writing by recognized tax counsel selected by the
Company and reasonably acceptable to the Executive.  Without limitation on the foregoing, the
payments made pursuant to this Section 17 shall be made no later than the
end of the year following the year in which the Executive remits such excise
tax to the Internal Revenue Service.  18.Entire
Agreement  This Agreement supersedes and
replaces the Key Executive Severance Agreement, dated as of February 1,
2008, between the parties, and except as described in Section 16 hereof,
this Agreement constitutes the entire agreement between the Company and the
Executive with respect to the subject matter hereof, and all prior or
contemporaneous oral or written communications, understandings or agreements
between the Company and the Executive with respect to such subject matter are
hereby superseded and nullified in their entireties, except that the
Proprietary Information and Invention Agreement between the Executive and the
Company shall continue in full force and effect to the extent not superseded by
Section 7 hereof.  19.Withholding  The Company may withhold from
any amounts payable under this Agreement such federal, state or local taxes as
shall be required to be withheld pursuant to any applicable law or regulation.  20.409A
Interpretation Provision  The parties intend that this
Agreement and the payments and benefits provided hereunder be exempt from the
requirements of Code Section 409A to the maximum extent possible, whether
pursuant to the short-term deferral exception described in Treasury Regulation Section 1.409A-1(b)(4),
the involuntary separation pay plan exception described in Treasury Regulation Section 1.409A-1(b)(9)(iii),
or otherwise.  To the extent Code Section 409A
is applicable to this Agreement, the parties intend that this Agreement comply
with the deferral, payout and other limitations and restrictions imposed under
Code Section 409A.  Notwithstanding
anything herein to the contrary, this Agreement is intended to be interpreted
and operated to the fullest extent possible so that the payments and benefits
under this Agreement either shall be exempt from the requirements of Code Section 409A
or shall comply with the requirements of such provision; provided, however,
that notwithstanding anything to the contrary in this Agreement in no event
shall the Company be liable to the Executive for or with respect to any taxes,
penalties or interest that may be imposed upon the Executive pursuant to Code Section 409A.  11


20.1        Payments
to Specified Employees  To the extent that any payment
or benefit pursuant to this Agreement constitutes a 409A Payment treated as
payable upon Separation from Service, then, if on the date of the Executives
Separation from Service, the Executive is a Specified Employee, then to the
extent required for the Executive not to incur additional taxes pursuant to
Code Section 409A, no such 409A Payment shall be made to the Executive
earlier than the earlier of (a) six (6) months after the Executives
Separation from Service or (b) the date of the Executives death.  Should this Section 20 result in the
delay of benefits, any such benefit shall be made available to the Executive by
the Company during such delay period at the Executives expense.  Should this Section 20.1 result in a
delay of payments or benefits to the Executive, on the first day any such
payments or benefits may be made without incurring additional tax pursuant to
Code Section 409A (409A Payment Date),
the Company shall make such payments and provide such benefits as provided for
in this Agreement, provided that any amounts that would have been payable
earlier but for the application of this Section 20.1 as well as
reimbursement of the amount the Executive paid for benefits pursuant to the
preceding sentence, shall be paid in a lump sum on the 409A Payment Date.  For purposes of this Section 20.1, the
term Specified Employee shall
have the meaning set forth in Code Section 409A, as determined in
accordance with the methodology established by the Company.  20.2        Reimbursements  For purposes of complying with
Code Section 409A and without extending the payment timing otherwise
provided in this Agreement, taxable reimbursements under this Agreement,
subject to the following sentence and to the extent required to comply with
Code Section 409A, will be made no later than the end of the calendar year
following the calendar year the expense was incurred.  To the extent required to comply with Code Section 409A,
any taxable reimbursements and any in-kind benefit under this Agreement will be
subject to the following:  (a) payment
of such reimbursements or in-kind benefits during one calendar year will not
affect the amount of such reimbursements or in-kind benefits provided during
any other calendar year (other than for medical reimbursement arrangements as
excepted under Treasury Regulation Section 1.409A-3(i)(1)(iv)(B) solely
because the arrangement provides for a limit on the amount of expenses that may
be reimbursed under such arrangement over some or all of the period the
arrangement remains in effect); (b) such right to reimbursements or
in-kind benefits is not subject to liquidation or exchange for another form of
compensation to the Executive, and (c) the right to reimbursements under
this Agreement will be in effect for the lesser of the time specified in this
Agreement or ten (10) years plus the lifetime of the Executive.  Any taxable reimbursements or in-kind
benefits shall be treated as not subject to Code Section 409A to the
maximum extent provided by Treasury Regulation Section 1.409A-1(b)(9)(v) or
otherwise under Code Section 409A.  20.3        Release  Subject to Section 20.1
hereof, (a) to the extent that the Executive is required to execute and
deliver a release to receive a 409A Payment and (b) this Agreement
provides for such 409A Payment to be provided prior to the 55th day following
the Executives Separation from Service, such 409A Payment will be provided
upon the 55th day following the Executives Separation  12


from Service,
provided that the release in the form acceptable to the Company, in its sole
discretion, has been executed, delivered and effective prior to such time.  To the extent there is a delay in providing a
409A Payment because of the provisions of this Section 20.3, interest for
the delay and the opportunity for the Executive to pay for benefits in the
interim with subsequent reimbursement from the Company shall be provided in a
manner consistent with that set forth in Section 20.1 hereof.  If a release is required for a 409A Payment
and such release is not executed, delivered and effective by the 55th day
following the Executives Separation from Service, such 409A Payment shall not
be provided to the Executive to the extent that providing such 409A Payment
would cause such 409A Payment to fail to comply with Code Section 409A.  20.4        No
Acceleration; Separate Payments  No 409A Payment payable under
this Agreement shall be subject to acceleration or to any change in the
specified time or method of payment, except as otherwise provided under this
Agreement and consistent with Code Section 409A.  If under this Agreement, a 409A Payment is to
be paid in two (2) or more installments, for purposes of Section 409A,
each installment shall be treated as a separate payment.  21.Counterparts  This Agreement may be executed
in counterparts, each of which counterpart shall be deemed an original, but all
of which together shall constitute one and the same instrument.  IN WITNESS WHEREOF, the parties
have executed and entered into this Agreement effective on the date first set
forth above.   PONIARD PHARMACEUTICALS, INC.By:
  /s/Gerald McMahonName: Gerald McMahonIts: Chairman &
  CEOEXECUTIVEBy:
  /s/ Robert
  L. De JagerName: Robert
  L. De Jager  13