<PAGE>
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                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                            ------------------------

                                   FORM 10-Q

(MARK ONE)

<TABLE>
<C>        <S>
   /X/     QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
           SECURITIES EXCHANGE ACT OF 1934
</TABLE>

               FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 1999
                                       OR

<TABLE>
<C>        <S>
   / /     TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
           SECURITIES EXCHANGE ACT OF 1934
</TABLE>

        FOR THE TRANSITION PERIOD FROM ______________ TO ______________

                         COMMISSION FILE NUMBER 0-28328

                            ------------------------

                                  UROCOR, INC.

             (Exact name of registrant as specified in its charter)

<TABLE>
<S>                                            <C>
               DELAWARE                                     75-2117882
       (State of incorporation)                 (IRS Employer Identification No.)

840 RESEARCH PARKWAY, OKLAHOMA CITY, OK                       73104
    (Address of principal executive                         (zip code)
               offices)
</TABLE>

                                 (405) 290-4000
              (Registrant's telephone number, including area code)

                                 NOT APPLICABLE
   (Former name, former address and former fiscal year, if changed since last
                                    report)

                            ------------------------

    Indicate by check mark whether the registrant: (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports) and (2) has been subject to such
filing requirements for the past 90 days. Yes /X/  No / /

    The number of shares of issuer's Common Stock, $.01 par value, outstanding
on November 10, 1999 was 9,226,315 shares.

--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
<PAGE>
                                  UROCOR, INC.

                                   FORM 10-Q

                    FOR THE QUARTER ENDED SEPTEMBER 30, 1999

                                     INDEX

                         PART I--FINANCIAL INFORMATION

<TABLE>
<CAPTION>
                                                                                          PAGE
                                                                                        --------
  <S>                     <C>                                                           <C>
  Item 1.                 Financial Statements (Unaudited)

                          Balance Sheets as of September 30, 1999 and December 31,        3
                            1998......................................................

                          Statements of Operations for the three and nine months ended    4
                            September 30, 1999 and 1998...............................

                          Statements of Cash Flows for the nine months ended
                            September 30, 1999 and 1998...............................    5

                          Notes to Unaudited Interim Financial                           6-7
                            Statements;mdaSeptember 30, 1999..........................

  Item 2.                 Management's Discussion and Analysis of Financial Condition    8-15
                            and Results of Operations.................................

  Item 3.                 Quantitative and Qualitative Disclosures About Market           15
                            Risks.....................................................

                                    PART II--OTHER INFORMATION

  Item 1.                 Legal Proceedings...........................................    16

  Item 2.                 Changes in Securities and Use of Proceeds...................    16

  Item 3.                 Defaults Upon Senior Securities.............................    16

  Item 4.                 Submission of Matters to a Vote of Security Holders.........    16

  Item 5.                 Other Information ..........................................  16-24
                            Cautionary Statements

  Item 6.                 Exhibits and Reports on Form 8-K............................    24

  Signatures..........................................................................    25
</TABLE>

                                       2
<PAGE>
                         PART I--FINANCIAL INFORMATION

ITEM 1. FINANCIAL STATEMENTS

                                  UROCOR, INC.

                                 BALANCE SHEETS

<TABLE>
<CAPTION>
                                                              SEPTEMBER 30,    DECEMBER 31,
                                                                   1999            1998
                                                              --------------   -------------
                                                               (UNAUDITED)
<S>                                                           <C>              <C>
                                           ASSETS
CURRENT ASSETS:
  Cash and cash equivalents.................................   $  9,559,855    $ 11,034,122
  Short-term marketable investments.........................      3,384,699       6,057,160
  Accounts receivable, net of allowance for doubtful
    accounts of $4,934,252 at
    September 30, 1999 and $6,029,066 at December 31,
    1998....................................................     10,530,128      15,964,744
  Prepaid expenses..........................................        245,035         946,403
  Laboratory supplies, at average cost......................        575,195         458,569
  Inventory.................................................        211,045         236,328
  Deferred tax asset - current, net.........................      5,252,868       3,159,855
  Other current assets......................................        673,263       1,065,909
                                                               ------------    ------------
      Total current assets..................................     30,432,088      38,923,091
                                                               ------------    ------------
LONG-TERM MARKETABLE INVESTMENTS............................      1,824,638       2,112,333
PROPERTY AND EQUIPMENT, net.................................      9,124,650       9,969,245
NON-CURRENT DEFERRED TAX ASSET, net.........................        247,630         174,671
INTANGIBLES AND OTHER ASSETS, net...........................      2,755,869       2,140,599
                                                               ------------    ------------
      Total assets..........................................   $ 44,384,875    $ 53,319,939
                                                               ============    ============
                            LIABILITIES AND STOCKHOLDERS' EQUITY

CURRENT LIABILITIES:
  Accounts payable..........................................   $  3,515,777    $  3,490,381
  Accrued compensation......................................        634,926         404,444
  Current installments of obligations under capital
    leases..................................................         32,373         209,092
  Other accrued liabilities.................................        227,725         372,427
                                                               ------------    ------------
      Total current liabilities.............................      4,410,801       4,476,344
DEFERRED COMPENSATION.......................................        186,401              --
OBLIGATIONS UNDER CAPITAL LEASES, net of current
  installments..............................................             --           8,607
                                                               ------------    ------------
      Total liabilities.....................................      4,597,202       4,484,951
                                                               ------------    ------------
STOCKHOLDERS' EQUITY:
  Preferred stock, $.01 par value, authorized 6,000,000
    shares at September 30, 1999 and at December 31, 1998;
    no shares issued and outstanding at September 30, 1999
    or at December 31, 1998.................................             --              --
  Common stock, $.01 par value, authorized 20,000,000 shares
    at September 30, 1999 and at December 31, 1998;
    10,654,081 shares issued at September 30, 1999 and
    10,492,726 shares issued and outstanding at
    December 31, 1998.......................................        106,541         104,927
  Common stock held in treasury at cost, 976,466 shares.....     (5,127,743)             --
  Additional paid-in capital................................     59,120,491      58,945,418
  Accumulated deficit.......................................    (14,311,616)    (10,215,357)
                                                               ------------    ------------
      Total stockholders' equity............................     39,787,673      48,834,988
                                                               ------------    ------------
      Total liabilities and stockholders' equity............   $ 44,384,875    $ 53,319,939
                                                               ============    ============
</TABLE>

   The accompanying notes are an integral part of these financial statements.

                                       3
<PAGE>
                                  UROCOR, INC.

                            STATEMENTS OF OPERATIONS

                                  (UNAUDITED)

<TABLE>
<CAPTION>
                                               THREE MONTHS ENDED           NINE MONTHS ENDED
                                                  SEPTEMBER 30,               SEPTEMBER 30,
                                            -------------------------   -------------------------
                                               1999          1998          1999          1998
                                            -----------   -----------   -----------   -----------
<S>                                         <C>           <C>           <C>           <C>
REVENUE...................................  $11,011,169   $11,802,243   $34,583,386   $33,680,084
OPERATING EXPENSES:
  Direct cost of services and products....    4,098,764     4,555,023    12,774,138    13,023,472
  Selling, general and administrative
    expenses..............................    6,417,334     6,048,164    20,040,036    17,548,680
  Research and development................      443,794       531,112     1,251,808     1,538,666
  Special charges.........................           --     8,205,606     7,409,777     8,205,606
                                            -----------   -----------   -----------   -----------
      Total operating expenses............   10,959,892    19,339,905    41,475,759    40,316,424
                                            -----------   -----------   -----------   -----------
OPERATING INCOME (LOSS)                          51,277    (7,537,662)   (6,892,373)   (6,636,340)
OTHER INCOME (LOSS):
  Interest, net...........................      191,138       271,813       677,372       905,176
  Other...................................       (3,317)     (339,125)      (46,349)     (339,125)
                                            -----------   -----------   -----------   -----------
      Total other income (loss), net......      187,821       (67,312)      631,023       566,051
                                            -----------   -----------   -----------   -----------
Income (loss) before income taxes.........      239,098    (7,604,974)   (6,261,350)   (6,070,289)
Income tax provision (benefit)............       84,879    (2,884,264)   (2,165,086)   (2,301,264)
                                            -----------   -----------   -----------   -----------
NET INCOME (LOSS).........................  $   154,219   $(4,720,710)  $(4,096,264)  $(3,769,025)
                                            ===========   ===========   ===========   ===========
NET INCOME (LOSS) PER SHARE:
Basic:
  Net Income (Loss) Per Common Share......  $       .02   $      (.45)  $      (.41)  $      (.36)
                                            ===========   ===========   ===========   ===========
  Weighted Average Common and Common
    Equivalent Shares Outstanding.........    9,663,827    10,422,252    10,076,512    10,382,736
                                            ===========   ===========   ===========   ===========
Diluted:
  Net Income (Loss) Per Common Share--
    Assuming Dilution.....................  $       .02   $      (.45)  $      (.41)  $      (.36)
                                            ===========   ===========   ===========   ===========
  Weighted Average Common and Common
    Equivalent Shares
    Outstanding--Assuming
    Dilution..............................   10,105,526    10,422,252    10,076,512    10,382,736
                                            ===========   ===========   ===========   ===========
</TABLE>

   The accompanying notes are an integral part of these financial statements.

                                       4
<PAGE>
                                  UROCOR, INC.

                            STATEMENTS OF CASH FLOWS

                                  (UNAUDITED)

<TABLE>
<CAPTION>
                                                                  NINE MONTHS ENDED
                                                                    SEPTEMBER 30,
                                                              -------------------------
                                                                 1999          1998
                                                              -----------   -----------
<S>                                                           <C>           <C>
CASH FLOWS FROM OPERATING ACTIVITIES:
  Net loss..................................................  $(4,096,264)  $(3,769,025)
  Adjustments to reconcile net loss to net cash provided by
    (used in) operating activities:
    Depreciation and amortization...........................    2,101,835     1,951,514
    Deferred income tax.....................................   (2,165,086)   (2,307,000)
    Stock option compensation expense.......................        6,864        93,085
    Deferred compensation...................................      186,401            --
    (Gain) loss on disposition of equipment.................       46,349        (3,380)
    Loss on asset write down................................    3,226,846     2,020,204
  Changes in assets and liabilities:
    (Increase) decrease in accounts receivable..............    5,434,616      (722,273)
    Decrease in prepaid expense.............................      701,368       196,808
    Increase in laboratory supplies.........................     (116,626)      (63,410)
    (Increase) decrease in inventory........................       25,283      (224,562)
    (Increase) decrease in other current assets.............      392,646      (550,927)
    Increase in accounts payable............................       25,396       804,316
    Increase in accrued compensation........................      230,482        81,090
    Increase (decrease) in accrued liabilities..............     (144,702)      772,476
                                                              -----------   -----------
      Net cash provided by (used in) operating activities...    5,855,408    (1,721,084)
                                                              -----------   -----------
CASH FLOWS FROM INVESTING ACTIVITIES:
    Maturities of short-term marketable investments, net....    2,672,461    10,632,958
    Maturities (purchases) of long-term marketable
      investments, net......................................      287,695      (114,684)
    Capital expenditures....................................   (4,454,706)   (3,898,862)
    Intangibles and other assets............................     (691,880)     (277,871)
                                                              -----------   -----------
      Net cash provided by (used in) investing activities...   (2,186,430)    6,341,541
                                                              -----------   -----------
CASH FLOWS FROM FINANCING ACTIVITIES:
    Proceeds from employee stock purchase plan..............       63,065       103,434
    Purchase of treasury shares.............................   (5,127,743)           --
    Proceeds from exercise of stock options.................      106,758       139,415
    Principal payments under capital lease obligations and
      other indebtedness....................................     (185,326)     (358,773)
                                                              -----------   -----------
      Net cash used in financing activities.................   (5,143,246)     (115,924)
                                                              -----------   -----------
Net increase (decrease) in cash and cash equivalents........   (1,474,268)    4,504,533

CASH AND CASH EQUIVALENTS, beginning of year................   11,034,123     6,896,033
                                                              -----------   -----------
CASH AND CASH EQUIVALENTS, end of period....................  $ 9,559,855   $11,400,566
                                                              ===========   ===========
SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:
    Cash paid for interest..................................  $    10,187   $    38,073
    Cash paid for income taxes..............................  $   300,000   $   550,000
</TABLE>

   The accompanying notes are an integral part of these financial statements.

                                       5
<PAGE>
                                  UROCOR, INC.

               NOTES TO INTERIM FINANCIAL STATEMENTS (UNAUDITED)

                               SEPTEMBER 30, 1999

NOTE 1--BASIS OF PRESENTATION:

    The accompanying unaudited financial statements have been prepared in
accordance with generally accepted accounting principles for interim financial
information and with the instructions to Form 10-Q and Article 10 of Regulation
S-X. Accordingly, they do not include all of the information and footnotes
required by generally accepted accounting principles for complete financial
statements. In the opinion of management, all adjustments (consisting of normal
recurring items) considered necessary for a fair presentation have been
included. These interim financial statements should be read in conjunction with
the financial statements and notes included in the Company's Annual Report on
Form 10-K for the year ended December 31, 1998 filed with the Securities and
Exchange Commission on March 31, 1999.

    Operating results for the nine-month period ended September 30, 1999 are not
necessarily indicative of the results that may be expected for the full year
ending December 31, 1999.

NOTE 2--SPECIAL CHARGES:

    During the second quarter of 1999, the Company recognized special charges
consisting of the following:

<TABLE>
<S>                                                           <C>
Increased provision for accounts receivable.................  $3,941,833
Information systems restructuring costs.....................   2,893,700
Settlement of certain Urology Support Services ("USS")
  claims....................................................     348,146
Severance costs for workforce reduction.....................     226,098
                                                              ----------
Total special charges.......................................  $7,409,777
                                                              ==========
</TABLE>

    Subsequent to increasing the provision for accounts receivable in the third
quarter of 1998, the Company continued reorganizing and streamlining its
accounts receivable and billing functions, which has resulted in improved
collections on recent billings. During the second quarter of 1999, however, the
Company discontinued certain managed care and payor related marketing programs
and identified significantly aged segments of its accounts receivable for which
the likelihood of collectibility is doubtful, or the expected benefit could
exceed the processing cost. Accordingly, a provision of $3,941,833 was made for
those receivable balances in the second quarter of 1999.

    During the second quarter of 1999, the Company accelerated an information
systems initiative to increase productivity, decrease costs and more efficiently
collect billings. As a result of this new operational focus on information
systems, the Company has restructured its information systems function and
terminated certain existing systems and internal software development projects.
The write-offs for systems and software projects related to this restructuring
totaled $2,893,700. Severance and outplacement costs associated with
restructuring this function and ending certain development projects totaled
$226,098 and $131,392 remains accrued as of September 30, 1999 for seven people
employed by the information systems function and three people employed in other
areas of the Company that were involved in terminated projects. The majority of
these amounts are anticipated to be paid by the end of 1999.

    At the end of the third quarter of 1998, the Company made the decision to
exit the USS business and accrued estimable costs associated with exiting this
business. During the second quarter of 1999, the Company settled claims by two
of the former clients of the USS business, which together with legal fees
incurred by the Company resulted in costs of $348,146 in excess of amounts that
had been previously accrued.

                                       6
<PAGE>
                                  UROCOR, INC.

         NOTES TO INTERIM FINANCIAL STATEMENTS (UNAUDITED) (CONTINUED)

                               SEPTEMBER 30, 1999

NOTE 3--NET INCOME (LOSS) PER COMMON SHARE:

    For the nine months ended September 30, 1999 and the three and nine months
ended September 30, 1998, the otherwise dilutive impact of outstanding stock
options and warrants is excluded from the computation of Diluted Net Loss Per
Share because such impact is antidilutive in the period of a net loss (i.e.,
consideration of such shares would result in a lower Diluted Net Loss Per Share
in comparison to the Basic Net Loss Per Share).

NOTE 4--INVESTMENTS:

    Pursuant to the Company's investment policy, idle and excess funds are
invested in high grade, fixed income securities generally for no more than two
years. These securities are considered available-for-sale as of September 30,
1999. The Company considers any net unrealized gain or loss on these investments
to be temporary, and reflects such gains or losses as a component of
stockholders' equity. As of September 30, 1999, there was not a material net
unrealized gain or loss on these investments.

NOTE 5--COMMITMENTS AND CONTINGENCIES:

    In July 1998 and March 1999, the Company received Civil Investigative
Demands ("CID") from the Department of Justice ("DOJ"). If the DOJ were to
pursue and prevail on matters that may arise from this investigation, any
significant recoupment of funds or civil or criminal penalty or exclusion from
federal and state health care programs potentially resulting from such
proceedings could have a material adverse effect on the financial condition and
results of operations of the Company.

NOTE 6--SUBSEQUENT EVENT:

    Effective October 26, 1999, William A. Hagstrom resigned as Chief Executive
Officer of the Company, and the Board of Directors elected Michael W. George,
formerly Chief Operating Officer, as successor to Mr. Hagstrom as Chief
Executive Officer. Mr. Hagstrom will continue as an employee of the Company and
as Chairman of the Board through December 31, 1999. The Board of Directors and
Mr. Hagstrom have agreed that Mr. Hagstrom will continue to serve the Company in
a consulting capacity for a period subsequent to his employment for compensation
comparable to his current annual base salary of $248,500, subject to discussion
and agreement regarding the terms of such engagement. The Company intends to
finalize the terms of the engagement in the fourth quarter of 1999.

NOTE 7--STOCK REPURCHASE PROGRAM:

    On April 20, 1999, the Board of Directors of the Company authorized the
repurchase by the Company of up to $10 million of UroCor common stock.
Management expects that the repurchase program will be conducted from time to
time on the open market or in privately negotiated transactions, depending upon
market conditions, securities regulations and other factors. As of November 10,
1999, the Company had repurchased approximately $6.7 million (or approximately
1.4 million shares) of common stock. Management also expects that, depending
upon the number of shares purchased, the Company may elect to supplement its
cash position with new debt.

                                       7
<PAGE>
ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
  OF OPERATIONS

    The following discussion of operations and financial condition of
UroCor, Inc. ("UroCor" or the "Company") should be read in conjunction with the
Financial Statements and Notes thereto included elsewhere in this Quarterly
Report on Form 10-Q. Special Note: Certain statements set forth below constitute
"forward-looking statements" within the meaning of Section 27A of the Securities
Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934,
as amended. See "Special Note Regarding Forward-Looking Statements" and
"Cautionary Statements" included elsewhere in this Report.

OVERVIEW

    UroCor markets a comprehensive range of integrated products and services to
assist in detecting, diagnosing, treating and managing prostate cancer, bladder
cancer, kidney stones and other complex urologic disorders directly to
urologists and managed care organizations. The Company's primary focus is
helping urologists improve patient care and outcomes while reducing the total
cost of managing these diseases.

    For the nine months ended September 30, 1999, the Company derived over 90%
of its revenue from diagnostic products and services that UroCor Labs-TM-
provides to the urology market to assist in the diagnosis, prognosis and
management of prostate cancer, bladder cancer and kidney stones disease. The
Company recognizes revenue when products are sold or services are rendered. The
Company typically bills various third-party payors for its products and
services, such as private insurance, managed care plans and governmental
programs (e.g., Medicare), as well as individual patients and physicians. For
the nine months ended September 30, 1999, approximately 47%, 44%, 5% and 4% of
the Company's diagnostic revenue was attributable to Medicare, private insurance
and managed care, individual patients, and physicians and hospitals,
respectively.

    During the nine months ended September 30, 1999, the Company derived
approximately 6% of its revenue from the marketing of two therapeutic products
for advanced prostate cancer including a one-time termination fee of $500,000
pursuant to a co-promotion agreement with a manufacturer. Under this agreement,
the Company recognizes revenue when earned based primarily on completed sales
calls. Pursuant to a termination notice received from the manufacturer in
September 1999, this agreement will terminate effective December 31, 1999; the
termination notice will not affect the Company's ability to recognize revenue
under this agreement in the 1999 fourth quarter.

    The Company also has worldwide marketing and distribution rights for
ProstaSeed-TM-, a UroCor branded line of radiation implants (also referred to as
"seeds") used in brachytherapy for early stage prostate cancer. This product
received clearance for marketing from the United States Food and Drug
Administration (the "FDA") in April 1999, and the manufacturer is now awaiting
approval from the Nuclear Regulatory Commission (the "NRC") before manufacturing
and commercial shipment of seeds can begin. The Company expects to begin
marketing this product in the United States in the fourth quarter of 1999.

    Additionally, the Company has distribution rights to a therapeutic product
for use in treating certain types of bladder cancer. The manufacturer of the
product is awaiting clearance by the FDA prior to marketing in the United
States, and has advised the Company that it expects to receive such clearance
before the end of 1999. If FDA clearance is obtained in 1999, the Company
expects to begin marketing this product in the first quarter of 2000.

RESULTS OF OPERATIONS

    REVENUE.  Revenue decreased 6.7%, from approximately $11.8 million to
$11.0 million for the three months ended September 30, 1998 compared to the
three months ended September 30, 1999, and

                                       8
<PAGE>
increased 2.7%, from approximately $33.7 million for the first nine months of
1998 to $34.6 million in the first nine months of 1999.

    Diagnostics revenue decreased 3.0% for the 1999 three-month period resulting
from a decrease in case volume of 1.0% and a 2.3% decrease in overall average
unit price. Diagnostic revenue increased 9.5% for the 1999 nine-month period
resulting primarily from a 13.5% increase in case volume, offset by a 3.3%
decrease in overall average unit price. The main contributor to the decreases in
overall average unit price was the higher volume growth for lower priced
products, including stones and microbiology, than in most of the Company's other
higher priced products. The diagnostics volume decline for the third quarter of
1999 was primarily the result of the second quarter 1999 elimination of certain
managed care related marketing programs and related collection efforts that
resulted in the loss of some clients and decreased product usage from other
clients. In the 1999 third quarter, the Company's client base was approximately
2,620 urologists of which 48% used two or more products compared to 2,650
urologists and 48% for the second quarter of 1999 and 2,500 urologists and 50%
for the third quarter of 1998. The Company intends to focus its marketing and
sales efforts for the remainder of 1999 on improving the diagnostics growth
rates and shifting the product mix to its most profitable products.

    Therapeutics product revenue decreased 26.2% from approximately
$1.3 million for the three months ended September 30, 1998 to approximately
$960,000 for the three months ended September 30, 1999, and decreased 43.8% from
approximately $3.7 million for the nine months ended September 30, 1998 to
approximately $2.1 million in the nine months ended September 30, 1999
principally due to a restructuring of the compensation terms of the related
co-promotion agreement effective January 1, 1999. Therapeutics product
co-promotion revenue for the three months ended September 30, 1999 included a
$500,000 early termination fee that became payable before March 2000 by the
manufacturer pursuant to the terms of the co-promotion agreement. Payment of the
fee was triggered by the manufacturer's delivery of notice in September 1999 of
termination without cause of the agreement effective December 31, 1999, which
will not affect the Company's ability to recognize revenue under this agreement
in the 1999 fourth quarter. Therapeutic revenues for 2000 and subsequent periods
are contingent upon the launch of products that are currently awaiting
regulatory approvals and any future acquisition of rights to other therapeutic
products that could be marketed by the Company.

    DIRECT COST OF SERVICES AND PRODUCTS.  As a percentage of revenue, direct
expenses decreased to 37.2% for the three months ended September 30, 1999 from
38.6% for the three months ended September 30, 1998 and decreased to 36.9% for
the nine months ended September 30, 1999 from 38.7% for the nine months ended
September 30, 1998. In the aggregate, direct cost of services and products
decreased 10.0%, from approximately $4.6 million in the three months ended
September 30, 1998 to approximately $4.1 million in the three months ended
September 30, 1999 and decreased 1.9% in the aggregate from approximately
$13.0 million for the nine months ended September 30, 1998 to approximately
$12.8 million for the nine months ended September 30, 1999. Direct costs for the
three and nine month periods ended September 30, 1998 included approximately
$347,000 and $772,000, respectively, for nonrecurring direct costs associated
with the Urology Support Services ("USS") business that the Company exited in
late 1998. As a percentage of revenue, direct costs for the three and nine month
periods ended September 30, 1998, excluding the direct costs associated with USS
would have been 35.7% and 36.4%, respectively. Compared to these adjusted
percentages for the 1998 periods, direct costs for the comparable 1999
three-month period increased from 35.7% to 37.2% and increased from 36.4% to
36.9% for the comparable 1999 nine-month period. The increase in this percentage
for the 1999 three-month and nine-month periods compared to the adjusted 1998
three-month and nine-month periods was the result of the decline in therapeutics
co-promotion revenue under the restructured terms of the co-promotion agreement.

    SELLING, GENERAL AND ADMINISTRATIVE EXPENSES.  As a percentage of revenue,
selling, general and administrative expenses increased to 58.3% for the three
months ended September 30, 1999 from 51.2% for the three months ended
September 30, 1998 and increased to 57.9% for the nine months ended
September 30, 1999 from 52.1% for the nine months ended September 30, 1998. In
the aggregate, selling,

                                       9
<PAGE>
general and administrative expenses increased 6.1%, from approximately
$6.0 million in the three months ended September 30, 1998 to approximately
$6.4 million in the three months ended September 30, 1999 and increased 14.2%,
from approximately $17.5 million in the nine months ended September 30, 1998 to
$20.0 million in the nine months ended September 30, 1999. Selling, general and
administrative expenses for the three and nine month periods ended
September 30, 1998 included approximately $144,000 and $497,000, respectively
for nonrecurring costs associated with the USS business that the Company exited
in late 1998. The increase in selling, general and administrative expenses was
due principally to increased management personnel, increased professional fees
related to addressing accounts receivable issues, increased personnel and
depreciation costs related to information services and billing efforts,
increased convention and meeting costs and the incurrence of over $460,000 and
$877,000 for the three and nine months ended September 30, 1999 related to
personnel, marketing and information systems in anticipation of the upcoming
launch of the Company's ProstaSeed-TM- product.

    RESEARCH AND DEVELOPMENT EXPENSES.  As a percentage of revenue, research and
development expenses decreased to 4.0% for the three months ended September 30,
1999 from 4.5% for the three months ended September 30, 1998 and to 3.6% for the
nine months ended September 30, 1999 from 4.6% for the nine months ended
September 30, 1998. In the aggregate, research and development costs decreased
16.4%, from approximately $531,000 in the three months ended September 30, 1998
to approximately $444,000 in the three months ended September 30, 1999, and
decreased 18.6% from approximately $1.5 million for the nine months ended
September 30, 1998 to approximately $1.3 million in the nine months ended
September 30, 1999. The decrease in expenses was due primarily to elimination of
non-strategic projects in the third quarter of 1998 resulting in overall lower
base research and development program costs.

    SPECIAL CHARGES.  During the second quarter of 1999, the Company recognized
special charges related primarily to two items. First, as part of its ongoing
assessment of accounts receivable and reserve adequacy, the Company terminated
certain managed care related marketing programs and identified significantly
aged segments of its accounts receivable for which the likelihood of
collectibility was doubtful. Accordingly, a provision of approximately
$3.9 million was made for these receivable balances. Second, the Company
launched an information systems initiative to increase productivity, decrease
costs and more efficiently collect billings. As a result of this new operational
focus for information systems, the Company restructured its information systems
function and terminated certain existing systems and internal software
development projects, resulting in approximately $2.9 million in asset
write-offs and approximately $226,000 in severance and outplacement costs.
Additionally, the Company settled claims with two former clients of the USS
business, which the Company exited in late 1998. These settlements totaled
approximately $348,000 in excess of amounts that had been accrued in 1998. The
aggregate charges for these three items totaled approximately $7.4 million for
the nine months ended September 30, 1999. Aggregate special charges for the
three and nine months ended September 30, 1998 were approximately $8.2 million,
including $4.7 million in accounts receivable provision, approximately
$2.2 million in exit costs related to USS and approximately $1.3 million in
non-strategic program asset write-offs, severance and other restructuring costs.
The following table sets forth the effects of the special charges and the 1998
operating losses of USS on UroCor's operating income for the three and nine
month periods ended September 30, 1999 and 1998.

<TABLE>
<CAPTION>
                                          THREE MONTHS ENDED         NINE MONTHS ENDED
                                            SEPTEMBER 30,              SEPTEMBER 30,
                                        ----------------------   -------------------------
                                          1999        1998          1999          1998
                                        --------   -----------   -----------   -----------
<S>                                     <C>        <C>           <C>           <C>
Operating income (loss), as
  reported............................  $51,277    $(7,537,662)  $(6,892,373)  ($6,636,340)
Operating income, excluding special
  charges and USS operating loss......  $51,277    $ 1,074,432   $   517,404   $ 2,721,438
</TABLE>

                                       10
<PAGE>
    OTHER INCOME (EXPENSE).  Interest income net of interest expense decreased
29.7%, from approximately $272,000 in the three months ended September 30, 1998
to approximately $191,000 in the three months ended September 30, 1999 and
decreased 25.2%, from approximately $905,000 in the nine months ended
September 30, 1998 to approximately $677,000 in the nine months ended
September 30, 1999. This decline was due principally to decreased cash, cash
equivalents and investments compared to the 1999 periods, resulting from the use
of such resources to fund stock repurchases and capital expenditures. Other
expense of approximately $3,000 and $46,000 for the three and nine months ended
September 30, 1999 was primarily due to routine disposition of assets. Other
expense of approximately $339,000 (the "1998 Non-recurring Expense") for both
the three and nine months periods ended September 30, 1998 was primarily due to
nonrecurring charges for professional advisor fees related to implementing the
Company's stockholder rights plan and review of an unsolicited purported
acquisition offer in the third quarter of 1998. The following table sets forth
the effects of the special charges, the operating losses of USS in 1998 and the
1998 Nonrecurring Expense on UroCor's net income and earnings per share for the
three and nine month periods ended September 30, 1999 and 1998.

<TABLE>
<CAPTION>
                                         THREE MONTHS ENDED         NINE MONTHS ENDED
                                           SEPTEMBER 30,              SEPTEMBER 30,
                                       ----------------------   -------------------------
                                         1999        1998          1999          1998
                                       --------   -----------   -----------   -----------
<S>                                    <C>        <C>           <C>           <C>
Net income (loss), as reported.......  $154,219   $(4,720,710)  $(4,096,264)  $(3,769,025)
Net income, excluding special
  charges, USS operating losses and
  1998 Nonrecurring Expense..........  $154,219   $   829,046   $   749,732   $ 2,243,053
                                       --------   -----------   -----------   -----------
Diluted income (loss) per share, as
  reported...........................  $    .02   $      (.45)  $      (.41)  $      (.36)
Diluted income per share, excluding
  special charges, USS operating
  losses and 1998 Nonrecurring
  Expense............................  $    .02   $       .08   $       .07   $       .22
</TABLE>

    INCOME TAXES.  Income tax benefit recorded in the three months ended
September 30, 1998 was approximately $2.9 million while an income tax expense of
approximately $85,000 was recorded in the three months ended September 30, 1999
based on a 35.5% effective federal and state income tax rate. For the nine
months ended September 30, 1998, income tax benefit of approximately
$2.3 million was recorded based upon a 38% effective rate, while an income tax
benefit of $2.2 million was recorded for the nine months ended September 30,
1999.

LIQUIDITY AND CAPITAL RESOURCES

    As of September 30, 1999, cash, cash equivalents and marketable investments
totaled approximately $14.8 million and the Company's working capital was
approximately $26.0 million. As of September 30, 1999, the components of cash,
cash equivalents and marketable investments were cash and cash equivalents of
approximately $9.6 million and short-term and long-term marketable investments
of approximately $3.4 million and $1.8 million, respectively, consisting
principally of high-grade fixed income securities with a maturity of less than
two years.

    Accounts receivable, net of allowance for doubtful accounts, totaled
approximately $10.5 million at September 30, 1999, a decrease of approximately
$5.4 million from December 31, 1998, or 34.0%. This decrease was principally
attributable to improved collections and the special charge for additional bad
debt recorded in the second quarter. At September 30, 1999 and December 31,
1998, the Company's average number of days sales in net diagnostics receivables
was approximately 89 and 110, respectively.

    Virtually all of the Company's diagnostic services are rendered on a
fee-for-service basis. Accordingly, the Company assumes the financial risk
related to collection, including potential inability to collect

                                       11
<PAGE>
accounts, long collection cycles for accounts receivable, difficulties in
gathering complete and accurate billing information and delays attendant to
reimbursement by third-party payors, such as governmental programs, private
insurance plans and managed care organizations.

    The Company monitors the collection quality of its accounts receivable
through analytical review of aging categories by payor group and collections
performance. In the second quarter of 1999, the Company recorded a special
charge of $3.9 million to increase the allowance for doubtful accounts in
respect of terminating certain managed care related marketing programs and
identifying significantly aged segments of its accounts receivable for which the
likelihood of collectibility was doubtful. In 1998, the Company recorded a
special charge of $4.7 million to increase the allowance for doubtful accounts
in respect of certain accounts for which the Company determined that the cost of
additional collection efforts would exceed the expected collections. Also in
1998, the Company determined that it had not sent invoices timely to certain
patients, primarily managed care patients, for certain co-pay, deductible and
other amounts relating principally to services rendered in 1998. In
December 1998, the Company commenced collection efforts for certain of these
amounts. The Company has taken steps to implement systems and processing changes
intended to improve its billing procedures and related collection results,
including actions taken in respect to the unsent invoices. Partially in response
to the collection efforts undertaken by the Company for the previously delayed
invoices to patients for co-pays, deductibles and other amounts determined in
1998, some urologists for such patients discontinued or reduced their use of the
Company's diagnostic services. The loss of any additional clients' business
could adversely affect the rate of the Company's growth in revenues and the
Company's results of operations.

    While the Company maintains what it believes to be an adequate allowance for
doubtful accounts, there can be no assurance that the Company's ongoing
assessment of accounts receivable will not result in the need for additional
provision for doubtful accounts. Such additional provision could have an adverse
effect on the Company's financial position and results of operations.

    In October 1997, the Company entered into a co-promotion agreement with the
manufacturer of two therapeutic products. This agreement was revised effective
January 1, 1999, and for the three months ended September 30, 1999, the Company
recorded revenue of approximately $459,000 and a nonrecurring fee of $500,000 as
a result of early termination under the agreement, as compared to $1.3 million
revenue for the three months ended September 30, 1998. The Company recognizes
revenue under the current agreement when earned based primarily upon sales calls
completed by the Company and has a potential to recognize a bonus in the fourth
quarter if certain sales goals are attained. In September 1999, the manufacturer
sent the Company a notice of termination without cause of the agreement
effective December 31, 1999, which will not affect the Company's ability to earn
revenue under this agreement in the 1999 fourth quarter. Therapeutic revenues
for 2000 and subsequent periods are contingent upon the launch of products that
are currently awaiting regulatory approvals and any future acquisition of rights
to other therapeutic products that could be marketed by the Company.

    Operating activities provided net cash of approximately $5.9 million for the
nine months ended September 30, 1999 compared to using net cash of approximately
$1.7 million for the nine months ended September 30, 1998. The net cash provided
by operating activities was primarily the result of a net loss of $4.1 million
and related income tax benefit of approximately $2.2 million, more than offset
by a special charge of $3.2 million for asset write-offs related to
restructuring the Company's information systems function and terminating certain
existing systems and internal software development projects in the second
quarter, a decrease in accounts receivable of approximately $5.4 million
resulting from increased collections and a special charge in the second quarter,
depreciation and amortization of approximately $2.1 million and a decrease in
prepaid assets of approximately $701,000.

    Net cash used by investing activities was approximately $2.2 million for the
nine months ended September 30, 1999 and consisted primarily of maturities of
short- and long-term marketable investments

                                       12
<PAGE>
of approximately $3.0 million, offset by capital expenditures of approximately
$4.5 million and intangible and other assets of approximately $692,000 related
to progress payments for marketing distribution rights.

    Net cash used in financing activities was approximately $5.1 million for the
first nine months of 1999, consisting primarily of purchases of stock pursuant
to the Company's stock repurchase program that commenced in April 1999.

    The Company's capital expenditures of approximately $4.5 million for the
nine months ended September 30, 1999, were primarily for leasehold improvements,
furniture and fixtures, and computer equipment and software associated with the
Company's relocation to newly constructed facilities adjacent to the former
facilities. Of the total amount, approximately $351,000 was related to internal
software development costs for information services. The Company has funded a
portion of the building tenant improvements and, in addition to expenditures
made in the nine months ended September 30, 1999, expects to incur at least an
additional $460,000 by the end of the fourth quarter of 1999 for such
improvements and other capital expenditures related to moving to the new
building. While future capital expenditures will depend upon a number of
factors, the level of expenditures is expected to be comparable to current
levels as the Company expands to deliver therapeutics and information services
and continues to enhance current diagnostic services and operational
capabilities. The Company intends to finance the majority of these capital
expenditures with existing cash and investment balances and possibly debt.

    In December 1994, the Company obtained distribution rights to a therapeutic
product currently awaiting clearance by the FDA prior to marketing in the United
States. The total cost of the distribution rights is $3.0 million, payable in
installments based on achievement of certain milestones by the manufacturer, of
which the Company has paid $1.25 million. The Company expects to pay an
additional milestone payment of $1.75 million if and when the product receives
clearance by the FDA for marketing in the United States. The manufacturer has
advised the Company that it expects to receive FDA clearance before the end of
1999. If the Company is required to make this payment, it intends to do so out
of existing cash and investment balances or debt. The Company has the right to
terminate this agreement at any time prior to FDA clearance of the product and
recoup the equivalent of payments already made.

    During 1998, the Company obtained marketing and other rights to two other
therapeutic products, and is obligated to pay up to an additional $350,000 to
the manufacturers based on achievement of certain milestones. In April 1999, the
Company paid one of such manufacturers $250,000 upon receiving clearance for
marketing from the FDA. In July 1999, the Company advanced one manufacturer
$150,000 towards the next milestone. As milestones are achieved, the Company
intends to make the additional payments from existing cash and investment
balances or debt.

    In April 1999, the Company's Board of Directors authorized the repurchase of
up to $10 million of the Company's common stock. As of November 10, 1999, the
Company had repurchased approximately $6.7 million (or approximately 1.4 million
shares) of its common stock. The Company intends to fund any such purchases
using available cash and cash flow from operations, and may elect to supplement
its cash position with new debt.

    The Company believes that its existing capital resources will be sufficient
to provide the funds necessary to maintain its present level of operations and
implement its currently planned growth strategy. However, there may be
circumstances or new business opportunities that would require additional
resources. In such event, the Company may be required to seek additional
financing and there is no assurance that the Company would be able to obtain
such financing on a timely basis or on acceptable terms.

IMPACT OF YEAR 2000 ISSUE

    The Year 2000 issue is the result of computer programming being written
using two digits rather than four to define the applicable year. Any of the
Company's systems, as well as those of key vendors, payors

                                       13
<PAGE>
and customers, that have date sensitive logic may interpret a date using "00" as
the year 1900 rather than 2000. This may result in inaccurate processing or
possible system failure causing potential disruption of operations, including
among other things a temporary inability to process transactions, send bills for
services or engage in similar normal business activities.

    The Company has implemented a Year 2000 program to address its current
information systems, desktop systems, laboratory equipment and infrastructures.
The program also addresses the Year 2000 readiness of key vendors and suppliers,
corporate partners, governmental agencies, banks and key customers and clients.
The program is being administered by an internal task force and consists of the
following phases:

       Phase 1: Compilation of an inventory of systems and relationships with
       suppliers, key customers and other business partners. This phase was
       completed in the first quarter of 1999.

       Phase 2: Final assessment of each item identified in the inventory
       compiled in Phase 1, verification of each item's compliance with Year
       2000 requirements and a resulting financial risk analysis. The assessment
       and verification portions of this phase were completed in the second
       quarter of 1999 and the financial risk analysis was completed in the
       third quarter of 1999.

       Phase 3: Resolution of any issues identified in Phase 2 and the
       development of a contingency plan, as necessary, to deal with internal
       and external risks associated with the Year 2000 issue. The Company
       previously expected to complete this phase for its internal systems by
       the end of the 1999 third quarter, however, due to an August 1999
       decision on systems replacements for its laboratory and billing systems,
       the Company has identified and commenced certain additional remediation
       efforts on existing systems. The Company has added this additional
       remediation work to the existing plan and has engaged additional
       resources to perform the necessary programming and testing. It is
       anticipated that this phase will now be completed by mid-December 1999
       for the Company's internal systems. Contingency planning for the
       Company's internal systems and processes is being facilitated by the
       internal task force working in conjunction with all applicable
       departments to identify possible Year 2000 impacts and documenting how
       such impacts will be dealt with. This documentation process will be
       on-going through the end of 1999, with the most significant risk areas
       being concentrated upon and documented first. The resolution of Year 2000
       issues for computer systems utilized in client's offices for the
       Company's Internet Report Delivery System ("IRDS") has been contracted
       out to a third-party vendor and is anticipated to be completed by the end
       of 1999. Contingency planning to address the impact that the Year 2000
       issues of third parties may have on the Company will be an on-going
       process as the Company becomes aware of such issues and will be taken
       into account in the contingency planning for internal systems and
       processes, as applicable.

    In 1998, UroCor's initial assessment of its internal computer systems and
related applications indicated that these systems and applications were prepared
to accommodate date-sensitive information relating to the Year 2000 issue.
Despite the delay in complete remediation for internal systems discussed under
Phase 3 above, UroCor expects that any additional costs related to ensuring its
systems to be Year 2000 compliant will not be material to the financial
condition or results of operations of the Company and that it will fund such
costs through existing working capital and operating cash flows. As of
September 30, 1999, the Company estimates that it has spent approximately
$80,000 specifically relating to the Year 2000 project. The Company continues to
analyze and monitor its total expected costs associated with Year 2000 issues,
and currently estimates that the total future expenditures specifically relating
to the Year 2000 project will be approximately $230,000. This cost information
represents management's best estimate, and there can be no assurance that
further review will not identify additional costs and efforts that will be
required and could cause actual results to differ materially from expectations.

    The ability of third parties with whom UroCor transacts business to address
their Year 2000 issues adequately is outside the Company's control. The most
significant exposure is to the federal government's

                                       14
<PAGE>
Medicare and Medicaid programs and with major insurance companies. These
customers in aggregate represent a material portion of the Company's revenue and
corresponding cash flow. As to suppliers and vendors, the most significant
exposures are those associated with services and products supply and
distribution. The Company will be monitoring industry reports to assess the
potential impact that Year 2000 issues could have on airports and air traffic
systems, as any such issues could impact the Company's ability to receive and/or
deliver specimens and supplies on a timely basis. Other than the potential
exposures listed above, the Company is not aware of any problems that would
materially impact results of operations, liquidity or capital resources. As the
ability of these third parties to address their Year 2000 issues adequately is
outside the Company's control, there can be no assurance that the failure of
third parties to address their respective Year 2000 issues adequately will not
have a material adverse effect on the Company's results of operations and
financial condition.

    Completion of the verification portion of Phase 2 did identify that
contingency plans will be needed as it relates to addressing any interruptions
of support provided by third parties resulting from their failure to be Year
2000 ready. In the event that any IRDS systems are found to be non-compliant by
January 1, 2000, the contingency plan will be for such clients to utilize the
Company's standard reporting process via fax and/or mail until the compliance
issue can be addressed. The Company expects to develop additional contingency
plans in Phase 3 as necessary. There can be no assurances that the Company will
be able to develop contingency plans that will adequately address all Year 2000
issues that may arise.

ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

    Pursuant to the Company's investment policy, idle and excess funds are
invested in high grade, fixed income securities generally for no more than two
years and are classified as Available-for-Sale. Marketable securities at
September 30, 1999 consisted primarily of debt securities with maturities as
long as two years. The Company considers any net unrealized gain or loss on
these investments to be temporary, and reflects such gains or losses as a
component of stockholders' equity. As of September 30, 1999 and December 31,
1998, there were no material net unrealized gains or losses on these
investments.

                                       15
<PAGE>
                           PART II--OTHER INFORMATION

ITEM 1.  LEGAL PROCEEDINGS

    None

ITEM 2.  CHANGES IN SECURITIES AND USE OF PROCEEDS

    USE OF PROCEEDS:

    The effective date of the registration statement for the Company's initial
public offering of Common Stock and for which this use of proceeds information
is being disclosed was May 16, 1996. The Commission file number assigned to the
registration statement was 333-3182.

    From the effective date of the registration statement through September 30,
1999, the following table identifies the purposes and amounts of the net
proceeds paid directly or indirectly to others:

<TABLE>
<S>                                                           <C>
Construction of plant, building and facilities..............  $       --
Purchase and installation of machinery and equipment........   6,953,252
Purchases of real estate....................................          --
Acquisition of other business(es)...........................          --
Repayment of indebtedness...................................   2,375,404
Working Capital.............................................   3,641,287
Temporary Investments:
  Short-term Commercial Paper...............................   2,378,854
  Long-term Corporate and Treasury Notes....................   2,830,483
  Cash Equivalents..........................................     922,293
Other Purposes:
  Development and Expansion of Diagnostic Product Line......   6,231,192
  Development of Information Products and Services and
    Urological Disease Databases............................   2,689,673
  Development of Therapeutic Product Line...................   2,585,285
  Development and Expansion of Clinical and Research
    Laboratories and Lab Information System.................   3,942,136
</TABLE>

    None of the net proceeds have been paid directly or indirectly to directors,
officers, general partners or their associates, to persons owning 10% or more of
any class of equity securities or affiliates.

ITEM 3.  DEFAULTS UPON SENIOR SECURITIES

    None

ITEM 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

    None

ITEM 5.  OTHER INFORMATION

    SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

    This Quarterly Report on Form 10-Q includes "forward-looking statements"
within the meaning of Section 27A of the Securities Act of 1933, as amended, and
Section 21E of the Securities Exchange Act of 1934, as amended. All statements
other than statements of historical facts included in this Report, including
without limitation, statements regarding the Company's financial position,
business strategy, products, products under development, markets, budgets and
plans and objectives of management for future operations, are forward-looking
statements. Although the Company believes that the expectations

                                       16
<PAGE>
reflected in such forward-looking statements are reasonable, it can give no
assurance that such expectations will prove to have been correct. Important
factors that could cause actual results to differ materially from the Company's
expectations are disclosed in statements set forth under "Cautionary Statements"
and elsewhere in this Report, including, without limitation, in conjunction with
the forward-looking statements included in this Report. All subsequent written
and oral forward-looking statements attributable to the Company, or persons on
its behalf, are expressly qualified in their entirety by the Cautionary
Statements and such other statements.

CAUTIONARY STATEMENTS

    RISKS ASSOCIATED WITH MANAGEMENT OF GROWTH.  Over the last several years,
the Company has experienced substantial growth in its diagnostics services
business and expanded its operational capabilities. The Company also intends to
develop further and expand its therapeutic products business and to offer
additional information services products. This growth and expansion has placed,
and will continue to place, a significant strain on the Company's management,
production, technical, financial and other resources. To date, the Company
primarily has experience in managing a diagnostics service business. There can
be no assurance that the Company will be able to manage successfully the
operation and expansion of its therapeutics or information services businesses.

    POTENTIAL FLUCTUATIONS IN OPERATING RESULTS.  The Company's quarterly and
annual operating results are affected by a wide variety of factors, many of
which are outside the Company's control, which have in the past and could in the
future materially and adversely affect revenue, operating expenses and income.
These factors include seasonality, the quantities and timing of specimens
received, competitive pricing pressures, reimbursement changes, availability and
cost of diagnostic supplies, availability and cost of logistic and delivery
services, changes in the mix of products sold, timing and costs of new product
and technology introductions by the Company or its competitors, retention and
expansion of the sales force and timing of payments from Medicare and other
third-party payors. The Company relies principally upon Federal Express, UPS and
Airborne Express for inbound and outbound shipping of specimens and kits for its
diagnostics operations; any disruption in the availability of such logistics and
delivery services could have a material adverse effect on the Company's
operating results. The need for continued investment in research and development
and expansion of its product lines could limit the Company's ability to reduce
expenses quickly. As a result of these factors, the Company's operating results
may continue to fluctuate in the future.

    UNCERTAINTIES RELATED TO GOVERNMENT REGULATION AND ENFORCEMENT.  As a
provider of health care related services, the Company is subject to extensive
and frequently changing federal, state and local laws and regulations governing
licensure, billing, financial relationships, referrals, conduct of operations,
purchase of existing businesses, cost-containment, direct employment of licensed
professionals by business corporations and other aspects of the Company's
business relationships. The various types of regulatory activity affect the
Company's business by controlling its growth, restricting licensure of the
business entity or by controlling the reimbursement for services provided. The
Company cannot predict the timing or impact of any changes in such laws and
regulations or their interpretations by regulatory bodies, and no assurance can
be given that any such changes will not have a material adverse effect on the
Company's financial condition and results of operations.

    Existing federal laws governing federal health care programs, including
Medicare, as well as some state laws, regulate certain aspects of the
relationship between health care providers, including the Company, and their
referral sources, including physicians, hospitals and other facilities. The
Anti-Fraud and Abuse Amendment and the Stark law generally prohibit providers
and others from soliciting, offering, receiving or paying, directly or
indirectly, any remuneration in return for making a referral for a service or
item and prohibit physicians, subject to certain exceptions, from making such
referrals to certain entities in which they have an investment interest or with
which they have a compensation arrangement. Violation of these prohibitions is
punishable by disallowance of submitted claims, civil monetary penalties and
criminal

                                       17
<PAGE>
penalties and exclusion from the Medicare and other federally funded programs.
The federal government has expanded its investigative and enforcement activities
in these areas. The federal government also has become more aggressive recently
in examining billing by laboratories and other health care providers, and in
seeking repayments and penalties based on how the services were billed (e.g. the
billing codes used), regardless of whether carriers had furnished clear guidance
on this subject.

    In July 1998, the Company received a Civil Investigative Demand ("CID") from
the Department of Justice ("DOJ") concerning allegations that the Company may
have submitted false claims in connection with bills for services submitted to
Medicare and other federal insurance programs. The Company received a second CID
from the DOJ in March 1999 concerning allegations that the Company may have
submitted false claims for payments, submitted false statements in support of
false claims, or conspired to submit false claims to government officials in
connection with bills for services submitted to Medicare and other federal
insurance programs by, among other things, bundling tests, billing for medically
unnecessary tests and upcoding. The DOJ has given the Company no further
information regarding the allegations. The CIDs require the Company to produce
certain documents to the DOJ. The Company produced documents to the DOJ in
response to both CIDs and is cooperating with the DOJ at this stage in the
investigation. Although the Company seeks to structure its practices to comply
with all applicable laws, no assurances may be given regarding the resolution of
this matter, and the Company is unable to predict its impact, if any, on the
Company. If the DOJ were to pursue and prevail on matters that may arise from
this investigation, any significant recoupment of funds or civil or criminal
penalty or exclusion from federal and state health care programs potentially
resulting from such proceedings could have a material adverse effect on the
financial condition and results of operations of the Company. In addition, any
related regulatory announcements or actions with respect to enforcement
activities could have a negative impact on the Company's stock price regardless
of the ultimate outcome of the matters under investigation.

    The Company's diagnostic laboratory operations currently are required to be
certified or licensed under the federal Clinical Laboratory Improvement Act of
1976, as amended in 1988, the Medicare and Medicaid programs and various state
and local laws. In some instances, the Company is also subject to licensing or
regulation under federal and state laws relating to the handling and disposal of
medical specimens, infectious and hazardous waste and radioactive materials, as
well as to the safety and health of laboratory employees. The sanctions for
failure to comply with these regulations may include denial of the right to
conduct business, significant fines and criminal penalties. Any exclusion or
suspension from participation in the Medicare program or certain state programs,
any loss of licensure or accreditation or any inability to obtain any required
license or permit, whether arising from any action by the Department of Health
and Human Services ("DHHS") or any state or any other regulatory authority,
could have a material adverse effect on the Company's business. Any significant
civil monetary or criminal penalty resulting from such proceedings could have a
material adverse effect on the Company's financial condition and results of
operations.

    While the Company currently knows of no plans that the FDA has to require
FDA approval of assays developed by laboratories for in-house use, the FDA has
in the past considered drafting guidelines for such regulation. If in the future
the FDA were to issue guidelines for the clinical laboratory market sector, such
guidelines might require the Company to meet certain FDA medical device approval
requirements for the Company's in-house assays. Such regulations, if enacted in
a way that affects the Company, would increase the cost of development and
approval of new products, slow their introduction to the market and could have a
material adverse effect on the Company's financial condition and results of
operations. Additionally, in a recent rule, the FDA stated that in some
circumstances involving in-house assays, laboratories will be required, upon
effectiveness of the rule, to indicate that the assay has not been cleared by
the FDA. There can be no assurance that such disclosure will not have an adverse
impact on reimbursement.

    The FDA currently regulates a number of the products which the Company
purchases from third parties for use in its diagnostic services. The
manufacturers of such products are responsible for compliance with FDA
regulations relating to such products. There can be no assurance, however, that
action by

                                       18
<PAGE>
the manufacturers or by the FDA would not impair the Company's ability to obtain
and offer certain services. The unavailability of certain services and materials
used in the Company's diagnostics business could have a material adverse effect
on the Company's financial condition and results of operations.

    The FDA regulates products licensed or otherwise acquired from third parties
and distributed or marketed by the Company. The manufacturers of such products
are responsible for compliance with the clearance and marketing regulations of
the FDA. The ability of such third parties to address their FDA regulatory
issues is outside the Company's control. There can be no assurance that the
failure of such third parties to address their FDA regulatory matters adequately
will not have a material adverse effect on the Company's financial condition and
results of operations. The FDA also regulates the introduction, manufacturing,
labeling and recordkeeping of the Company's therapeutic products currently
marketed or that the Company may market in the future. In addition, most users
of the Company's ProstaSeed-TM- product that the Company expects to market in
the future will be required to possess licenses issued by the state in which
they reside or by the NRC.

    Although the Company's existing and proposed information services products
currently are not subject to regulation by the FDA, the FDA could determine in
the future that the predictive applications of these products are deemed to be
medical devices subject to FDA regulation. In that event, the Company could
experience delays in developing and marketing new services and increases in
research and development costs.

    UNCERTAINTIES RELATED TO THIRD-PARTY REIMBURSEMENT.  The Company typically
bills governmental programs such as Medicare and other third-party payors such
as private insurance and managed care plans for its products and services. Such
third-party payors are increasingly negotiating prices with the goal of lowering
reimbursement rates, which may result in lower profit margins for the Company.
Reimbursement rates have been established for most but not all of the services
performed by the Company. The Company cannot collect from Medicare or other
third-party payors for services that those payors have not approved for
reimbursement. The Company routinely bills for direct reimbursement for both
medical services and products. As is common with all suppliers of medical
services and devices, there is a certain amount of variability with respect to
reimbursement among third party payor sources. The Company's Persist Treatment
System product currently is not widely accepted for reimbursement within the
healthcare market. The product has been marketed for less than one year and
remains a relatively new approach to treating incontinence. There can be no
assurance that the Persist Treatment System or any other new products the
Company currently has under development will be accepted for reimbursement by
Medicare or other third-party payors. Such uncertainty makes the amount and
timing of such products' reimbursement difficult to predict, which potentially
subjects the Company to reimbursement risks with respect to accounts receivable.
Furthermore, Medicare and other third party payors have, on occasion, ceased
reimbursement when certain tests are ordered for patients with certain diagnoses
while maintaining reimbursement when those tests are ordered for other diagnoses
deemed appropriate by the carrier. This practice has recently become more
prevalent with respect to Medicare. Medicare may retroactively audit and review
its payments to the Company and may determine that certain payments for services
must be returned. In addition, if the Company is unable to become an approved
participating provider under certain managed care programs that cover a number
of patients of any particular physician, that physician, to simplify purchasing
and billing, may elect to use a competitor of UroCor that is approved by such
managed care organizations for all of his or her needs, regardless of whether
other patients are covered by Medicare or other third party payors. The loss of
key urologists and their patients could have a material adverse affect on the
Company's financial condition and results of operations.

    POTENTIAL HEALTH CARE REFORM.  From time to time, the public and federal
government focus significant attention on reforming the health care system in
the United States. In 1997, Congress enacted the Balanced Budget Act that
effected numerous changes to the Medicare and Medicaid programs that could
affect health care providers, including clinical laboratories. The 1997 act also
revised the resource-based relative value scale system that could affect health
care providers that offer physician pathology services.

                                       19
<PAGE>
These 1997 changes and any future changes in Medicare and other third-party
payor reimbursement which may result from health care reform or deficit
reduction legislation will likely continue the downward pressure on prices. A
number of other legislative proposals have been introduced in Congress and state
legislatures in recent years that would effect major reforms of the health care
system and otherwise reduce health care spending. Because of the uncertainties
surrounding the nature, timing and extent of any such reimbursement changes,
audits and reform initiatives, the Company is unable to predict the effects of
any such matters on the Company.

    DEPENDENCE ON CERTAIN PRODUCT LINES. A significant portion of the Company's
revenue has been, and is expected to continue to be, dependent upon the
Company's prostate tissue analysis and bladder cellular analysis product lines.
Any negative event related to these product lines, such as increased
competition, pricing pressures, reimbursement changes and clinical or
technological obsolescence, could have a material and adverse effect on the
Company's financial condition and results of operations.

    NO ASSURANCE OF ACCESS TO AND DELIVERY OF NEW DIAGNOSTIC TECHNOLOGY.  The
markets for the Company's diagnostic products and services are characterized by
rapidly changing technology, frequent new product introductions and enhancement
and, therefore, rapid product obsolescence. There can be no assurance the
Company will be able to identify new products, trends or opportunities, develop
and bring to market new products, respond effectively to new technological
changes or product announcements by others, develop or obtain access to advanced
materials and technologies or receive commercial acceptance for its products.

    UNCERTAINTIES RELATED TO THE REGULATORY REVIEW OF THERAPEUTIC PRODUCTS.  The
Company has a distribution agreement with BioChem Vaccines, Inc. ("BioChem"), a
subsidiary of BioChem Pharma, Inc., for a therapeutic product for use in
treating certain types of bladder cancer. Pursuant to the distribution
agreement, BioChem is responsible for obtaining clearance from the FDA for
marketing the therapeutic product in the United States. In April 1995, BioChem
filed its initial applications with the FDA. In April 1996, the FDA advised
BioChem that its application was not approvable and requested additional data
regarding certain aspects of manufacturing and testing of the product, which
BioChem filed with the FDA through an amended application in August 1996.
Following a May 1997 site inspection of BioChem's manufacturing facilities and
operations, the FDA issued a report on FDA Form 483 indicating that additional
requirements related to BioChem's facility, process and documentation were
required before these applications could be approved. As a result of an
August 1998 FDA site visit, resulting FDA Form 483 and subsequent discussions
between BioChem and the FDA, BioChem has undertaken upgrading certain portions
of its manufacturing process and facility to meet FDA requirements. BioChem has
advised the Company that it believes it can satisfy the FDA requirements and
receive FDA clearance in 1999, however, there can be no assurance that FDA
clearance will be obtained.

    The Company also has a marketing agreement with the manufacturer of a
therapeutic product used for early stage prostate cancer. Pursuant to the
marketing agreement, the manufacturer filed a Form 510(k) with the FDA in
December 1998 for marketing clearance and such clearance was obtained in
April 1999. The manufacturer is responsible for obtaining an additional approval
from the Nuclear Regulatory Commission ("NRC") before commercial shipment of the
product can begin. There can be no assurance that such approval will be
obtained. Additionally, since the manufacturer has not previously produced this
therapeutic product, there can be no assurance of the manufacturer's ability to
produce quantities effectively or in a manner compliant with all FDA and NRC
regulations.

    UNCERTAINTIES RELATED TO ACCOUNTS RECEIVABLE.  Virtually all of the
Company's diagnostic services are rendered on a fee-for-service basis.
Accordingly, the Company assumes the financial risk related to collection,
including potential inability to collect accounts, long collection cycles for
accounts receivable, difficulties in gathering complete and accurate billing
information and delays attendant to reimbursement by third-party payors, such as
governmental programs, private insurance plans and managed care organizations.
At times, the Company's accounts receivable have increased at a rate greater
than revenue growth and, therefore, have affected the Company's cash flow from
operations. In addition, in 1998, the Company

                                       20
<PAGE>
determined that it had not sent invoices timely to certain patients, primarily
managed care patients, for certain co-pays, deductibles and other amounts
relating principally to services rendered in 1998. In December 1998, the Company
commenced collection efforts for certain of these amounts. As a result of delay
in sending such invoices, the Company has had difficulty in its collection
efforts. The Company has previously taken steps to implement systems and
processing changes intended to improve billing procedures and related collection
results, and, in response to the unsent invoices, it is has undertaken
additional initiatives to further improve claims efficiencies and collection
results, in addition to assessing the ultimate collectibility of outstanding
balances. While the Company's management believes it has made progress by
reorgainizing and streamlining its accounts receivable and billing functions,
and the Company maintains what it believes to be an adequate allowance for
doubtful accounts, there can be no assurance that the Company's ongoing
assessment of accounts receivable will not result in the need for additional
provision for doubtful accounts. Such additional provision could have a material
adverse affect on the Company's results of operations.

    NO ASSURANCE OF SUCCESSFUL MARKETING ARRANGEMENTS FOR THERAPEUTIC
PRODUCTS.  The Company conducts marketing activities for therapeutic products
through its UroTherapeutics Group. The Company currently markets three products
and has acquired distribution rights for two other therapeutic products, and,
pursuant to the manufacturer's September 1999 notice of termination without
cause, effective December 31, 1999, the Company will no longer market two of the
products it currently markets. While the Company has experience marketing three
of the therapeutic products, there can be no assurance that the Company's future
efforts will be successful. UroCor's future therapeutics marketing efforts are
dependent, in part, upon acquiring, licensing and co-promoting additional
pharmaceuticals or medical devices from others. Other companies, including those
with substantially greater resources, are competing with UroCor for the rights
to such products. There can be no assurance that UroCor will be able to acquire,
license or co-promote additional pharmaceuticals or medical devices on
acceptable terms, if at all. The failure to acquire, license, co-promote or
market commercially successful pharmaceuticals or medical devices could have a
material adverse effect on the Company's financial condition and results of
operations. There can be no assurance that, once it has obtained rights to a
pharmaceutical or medical device product and committed to payment terms, UroCor
will be able to generate sales sufficient to create a profit or otherwise avoid
a loss on such product. Additionally, the Company has not previously marketed to
the radiation oncology and medical oncology markets that will be pursued for
sales of the Company's ProstaSeed-TM- product, and there can be no assurance
that the Company will be successful in these marketing and sales efforts.

    In addition, the Company is and will be dependent on third party
manufacturers to produce the products that are the subject of the Company's
marketing and distribution agreements. If such manufacturers are unable to
produce the products, produce adequate quantities or produce them in a manner
that is compliant with all regulatory requirements, the Company's marketing and
distribution agreements are subject to termination and potential liabilities
that could have a material and adverse effect on the Company's financial
condition and results of operations.

    POTENTIAL THERAPEUTICS PRODUCT LIABILITY OR RECALL.  In the event UroCor
increases its marketing of therapeutic products, it will face increasing
exposure to product liability claims in the event that the use of any of its
therapeutic products is alleged to have resulted in adverse effects. Such risks
will exist even with respect to those products that receive regulatory clearance
for commercial sale. While UroCor has taken, and intends to continue to take,
what it believes are appropriate precautions, there can be no assurance that it
will avoid significant product liability exposure or product recalls. UroCor
currently has product liability insurance; however, there can be no assurance
that the level or breadth of any insurance coverage will be sufficient to cover
potential claims. There can be no assurance that adequate insurance coverage
will be available in the future at acceptable costs, if at all, or that a
product liability claim or recall would not have a material adverse effect on
the Company's financial condition and results of operations.

                                       21
<PAGE>
    RISKS ASSOCIATED WITH INVESTMENTS IN DISEASE MANAGEMENT INFORMATION
SYSTEMS.  The Company has been and expects to continue investing in the
development of information-based capabilities and services which it plans to
introduce or use in the future related to the clinical management of urologists'
patients. The Company has developed and introduced, on a limited basis, disease
outcomes reporting capabilities in one disease state. Further development and
delivery of these new services may require substantial additional investment and
represents an expansion of the type of services the Company presently provides
to urologists. There can be no assurance that any future revenues directly or
indirectly from these services will be sufficient to cover or otherwise justify
the costs of development and introduction.

    RISKS ASSOCIATED WITH DEVELOPMENT OF DATABASES.  The confidentiality of
patient medical records is subject to substantial regulation by state and
federal governments. State and federal laws and regulations govern both the
disclosure and the use of confidential patient medical record information.
Legislation governing the dissemination and use of medical record information is
being proposed continually at both the state and federal levels. For example,
the Health Insurance Portability and Accountability Act ("HIPAA") requires the
Secretary of the DHHS to recommend legislation or to promulgate regulations
governing privacy standards for individually identifiable health information.
Additional legislation may require that holders or users of confidential patient
medical information implement measures to maintain the security of such
information and may regulate the dissemination of even anonymous patient
information. Physicians and other persons providing patient information to the
Company also are required to comply with these laws and regulations. If a
patient's privacy is violated, or if the Company is found to have violated any
state or federal statute or regulation with regard to the confidentiality,
dissemination or use of patient medical information, the Company could be liable
for damages, or fines or penalties. The Company believes that it complies in all
material respects with all applicable state and federal laws and regulations
governing the confidentiality, dissemination and use of medical record
information. However, there can be no assurance that differing interpretations
of existing laws and regulations or the adoption of new laws and regulations
would not have a material adverse effect on the ability of the Company to obtain
or use patient information which, in turn, could have a material adverse effect
on the Company's plans to develop and market its urology disease information
database and related treatment. The Company intends to continue to monitor and
review the interpretation and enactment of laws and regulations which affect the
Company's plans to develop and market its urology disease information database.
In addition, the American Medical Association (the "AMA") has issued an opinion
to the effect that a physician who does not obtain a patient's consent to the
disclosure of the patient's medical record information violates the AMA's
ethical standards. While the AMA's opinions are not law, they may influence the
willingness of physicians to obtain patient consents or to disclose patient
medical information to the Company and thus could have a material adverse effect
on the Company's plans to develop and market its urology disease information
database.

    UNCERTAINTIES RELATED TO MANAGED CARE.  Managed care organizations are
gaining increasing control over access to health care and payment for an
increasing number of patients with urologic diseases. There can be no assurance
that the Company will be able to maintain its existing contracts with managed
care organizations or that it will be able to obtain additional contracts with
such organizations in the future, which could preclude the Company from serving
large groups of patients in certain markets. The Company has experienced
increasing pricing pressure from managed care organizations, and such pressure
is expected to continue. There can be no assurance that such pricing pressure
and any contract restrictions will not have a material adverse effect on the
Company's financial condition and results of operations.

    UNCERTAINTIES RELATED TO PATENTS AND PROPRIETARY RIGHTS.  While UroCor's
success does not depend on its ability to obtain patents, there can be no
assurance that it can operate without infringing upon the proprietary rights of
others. UroCor has licenses or license rights to certain United States patent
and patent applications. On UroCor's own patent applications, there can be no
assurance that patents, United States or foreign, will be obtained, or that, if
issued or licensed, they will be enforceable or will provide substantial
protection from competition or be of commercial benefit, or that UroCor will
possess the

                                       22
<PAGE>
financial resources necessary to enforce or defend any of its patent rights.
Federal court decisions establishing legal standards for determining the
validity and scope of patents in the field are in transition. There can be no
assurance that the historical legal standards surrounding questions of validity
and scope will continue to be applied or that current defenses as to issued
patents in the field will offer protection in the future. UroCor must also avoid
infringing patents issued to competitors and must maintain technology licenses
upon which certain of its current products are, or any future products under
development might be, based. Litigation, which could result in substantial cost
to the Company, may be necessary to enforce its patent and license rights or to
determine the scope and validity of proprietary rights of third parties. If any
of UroCor's products are found to infringe upon patents or other rights owned by
third parties, it could be required to obtain a license to continue to utilize
or market such products. There can be no assurance that licenses to such patent
rights would be made available to the Company on commercially reasonable terms,
if at all. If UroCor does not obtain such licenses, it could encounter delays in
marketing affected products or be precluded from marketing them at all.

    COMPETITIVE PRESSURES.  The industry in which the Company's diagnostics
business operates is characterized by intense competition with many different
types of competitors including specialty laboratories, diagnostic kit and
instrumentation manufacturers, local, regional and national pathology services,
hospital laboratories and general reference clinical laboratories. Many of the
Company's competitors are significantly larger and have significantly greater
financial, technical and administrative resources than the Company; many of the
Company's competitors also have long established relationships with the
Company's current and prospective customers and with managed care organizations.
There can be no assurance that the Company will be able to compete successfully
with such entities in the marketing of products and services and in the
acquisition of new technologies.

    Many companies, including large pharmaceutical firms with financial and
marketing resources and development capabilities substantially greater than
those of UroCor, are engaged in developing, marketing and selling therapeutic
products that compete with the drugs and devices offered or planned to be
offered by the Company. The selling prices of such products frequently decline
as competition increases. Further, other products now in use or under
development by others may be more effective than UroCor's current or future
products. The industry is characterized by rapid technological change, and new
or presently competing products may prevent the Company's products from gaining
sufficient market share to attain profitability. As a result of increasing
competition in marketing to urologists, the Company's ability to attract and
retain sales representatives and management may also affect its ability to
compete in the marketing of both diagnostic services and therapeutics. There can
be no assurance that the Company will be able to compete successfully in
marketing therapeutic products.

    YEAR 2000 RISKS.  The Company has completed an assessment of the ability of
its information systems and related applications to accommodate date-sensitive
information relating to the Year 2000 issue. A plan has been developed that is
designed to remediate all internal systems by the end of 1999, however, there
can be no assurance that such remediation efforts will be successful or that the
Company will not identify additional Year 2000 related systems problems that
could require significant expenditures to address. Additionally, the ability of
third parties with whom the Company transacts business to adequately address
their Year 2000 issues is outside the Company's control. The Company has an
ongoing project to communicate with the third parties with which it does
business to coordinate Year 2000 compliance. There can be no assurance that the
failure of the Company or such third parties to adequately address their
respective Year 2000 issues will not have a material adverse effect on the
Company's financial condition and results of operations.

    ACCESS TO CAPITAL.  The Company's growth since 1991 has required, and any
future growth will require, significant amounts of working capital. Although the
Company believes that existing capital resources will be adequate to fund its
present level of operations and implement its currently planned growth strategy,
there may be circumstances or new business opportunities that would require the

                                       23
<PAGE>
Company to seek additional financial resources. There is no assurance that the
Company would be able to obtain such financing on a timely basis or on
acceptable terms.

ITEM 6.  EXHIBITS AND REPORTS ON FORM 8-K.

    (a) Exhibits:
       None.

    (b) Reports on Form 8-K
       None.

                                       24
<PAGE>
                                   SIGNATURES

    Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.

<TABLE>
<S>                                                    <C>  <C>
                                                       UROCOR, INC.

                                                       By:            /s/ MICHAEL W. GEORGE
                                                            -----------------------------------------
                                                                        Michael W. George
                                                              PRESIDENT AND CHIEF EXECUTIVE OFFICER
</TABLE>

       November 15, 1999

<TABLE>
<S>                                                    <C>  <C>
                                                       By:             /s/ BRUCE C. HAYDEN
                                                            -----------------------------------------
                                                                         Bruce C. Hayden
                                                              SENIOR VICE-PRESIDENT, CHIEF FINANCIAL
                                                                 OFFICER, TREASURER AND SECRETARY
</TABLE>

       November 15, 1999

                                       25