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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549



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FORM 10-Q



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|x | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ---------------------------------------------------------------------------------------

For the quarterly period ended March 31, 2007

or



| ̈ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
|- | ----------------------------------------------------------------------------------------

Commission File Number: 0-21699



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VIROPHARMA INCORPORATED

(Exact Name
of Registrant as Specified in its Charter)



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|                                                               |  |                                     
|-------------------------------------------------------------- |  | ------------------------------------
|Delaware                                                       |  | 23-2789550                          
|(State or other jurisdiction of incorporation or organization) |  | (I.R.S. Employer Identification No.)

397 Eagleview Boulevard

Exton, Pennsylvania 19341

(Address of Principal Executive Offices and Zip
Code)

610-458-7300

(Registrants Telephone Number, Including Area Code)



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Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934
during the preceding 12 months (or for such shorter period that the registrant was required to file such reports) and (2) has been subject to such filing requirements for the past 90 days.    Yes  x    No ̈

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer. See definition of accelerated filer and large accelerated filer in Rule 12b-2
of the Exchange Act. (Check one):

Large Accelerated Filer ̈Accelerated Filer  x    Non-accelerated filer ̈

Indicate by check mark whether the registrant is a shell company (as defined
in Rule 12b-2 of the Exchange Act).    Yes ̈No  x

Number of shares outstanding of the issuers Common Stock, par value $.002 per share, as of April 27, 2007:
69,792,522 shares.



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VIROPHARMA INCORPORATED

INDEX



|                             |  |                                                                                                                |  |     
|---------------------------- |  | -------------------------------------------------------------------------------------------------------------- |  | ----
|                             |  |                                                                                                                |  | Page
|PART I FINANCIAL INFORMATION |  |                                                                                                               
|                             |  |                                                                                                               
|Item 1.                      |  | Financial Statements                                                                                           |  |     
|                             |  |                                                                                                               
|                             |  | Condensed Consolidated Balance Sheets (unaudited) at March 31, 2007 and December 31, 2006                      |  | 3   
|                             |  |                                                                                                               
|                             |  | Consolidated Statements of Operations (unaudited) for the three months ended March 31, 2007 and 2006           |  | 4   
|                             |  |                                                                                                               
|                             |  | Consolidated Statements of Stockholders Equity (unaudited) for the three months ended March 31, 2007 and 2006 |  | 5   
|                             |  |                                                                                                               
|                             |  | Consolidated Statements of Cash Flows (unaudited) for the three months ended March 31, 2007 and 2006           |  | 6   
|                             |  |                                                                                                               
|                             |  | Notes to the Consolidated Financial Statements (unaudited)                                                     |  | 7   
|                             |  |                                                                                                               
|Item 2.                      |  | Managements Discussion and Analysis of Financial Condition and Results of Operations                          |  | 15  
|                             |  |                                                                                                               
|Item 3.                      |  | Quantitative and Qualitative Disclosures About Market Risk                                                     |  | 27  
|                             |  |                                                                                                               
|Item 4.                      |  | Controls and Procedures                                                                                        |  | 27  
|                             | 
|PART II OTHER INFORMATION    |  |                                                                                                               
|                             |  |                                                                                                               
|Item 1A.                     |  | Risk Factors                                                                                                   |  | 28  
|                             |  |                                                                                                               
|Item 6.                      |  | Exhibits                                                                                                       |  | 31  
|                             | 
|SIGNATURES                   |  | 32                                                                                                            



2



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ViroPharma Incorporated

Condensed Consolidated Balance Sheet

(unaudited)



|                                                                                                                                                                               |  |               |         |   |                   |   |         |  
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ |  | ------------- | ------- | - | ----------------- | - | ------- | -
|(in thousands, except share and per share data)                                                                                                                                |  | March 31,2007 |         |   | December 31, 2006 |  
|Assets                                                                                                                                                                         |  |               |         |   |                   |   |         |  
|Current assets:                                                                                                                                                                |  |               |         |   |                   |   |         |  
|Cash and cash equivalents                                                                                                                                                      |  | $             | 252,052 |   |                   | $ | 51,524  |  
|Short-term investments                                                                                                                                                         |  |               | 228,574 |   |                   |   | 203,885 |  
|Accounts receivable, net                                                                                                                                                       |  |               | 22,983  |   |                   |   | 9,447   |  
|Inventory                                                                                                                                                                      |  |               | 5,771   |   |                   |   | 4,760   |  
|Interest receivable                                                                                                                                                            |  |               | 3,564   |   |                   |   | 3,290   |  
|Prepaid expenses and other                                                                                                                                                     |  |               | 1,481   |   |                   |   | 2,027   |  
|Income taxes receivable                                                                                                                                                        |  |               |        |   |                   |   | 80      |  
|Deferred income taxes                                                                                                                                                          |  |               | 9,154   |   |                   |   | 9,225   |  
|                                                                                                                                                                               |  |               |         |   |                   |   |         |  
|Total current assets                                                                                                                                                           |  |               | 523,579 |   |                   |   | 284,238 |  
|Intangible assets, net                                                                                                                                                         |  |               | 121,656 |   |                   |   | 122,672 |  
|Property, plant and equipment, net                                                                                                                                             |  |               | 11,037  |   |                   |   | 2,828   |  
|Deferred income taxes                                                                                                                                                          |  |               | 14,191  |   |                   |   | 19,907  |  
|Debt issue costs, net                                                                                                                                                          |  |               | 8,162   |   |                   |   |        |  
|Other assets                                                                                                                                                                   |  |               |        |   |                   |   | 49      |  
|                                                                                                                                                                               |  |               |         |   |                   |   |         |  
|Total assets                                                                                                                                                                   |  | $             | 678,625 |   |                   | $ | 429,694 |  
|                                                                                                                                                                               |  |               |         |   |                   |   |         |  
|Liabilities and Stockholders Equity                                                                                                                                           |  |               |         |   |                   |   |         |  
|Current liabilities:                                                                                                                                                           |  |               |         |   |                   |   |         |  
|Accounts payable                                                                                                                                                               |  | $             | 2,668   |   |                   | $ | 2,743   |  
|Due to partners                                                                                                                                                                |  |               | 1,033   |   |                   |   | 783     |  
|Accrued expenses and other current liabilities                                                                                                                                 |  |               | 10,847  |   |                   |   | 14,129  |  
|Income taxes payable                                                                                                                                                           |  |               | 1,356   |   |                   |   | 140     |  
|                                                                                                                                                                               |  |               |         |   |                   |   |         |  
|Total current liabilities                                                                                                                                                      |  |               | 15,904  |   |                   |   | 17,795  |  
|Long-term debt                                                                                                                                                                 |  |               | 250,000 |   |                   |   |        |  
|                                                                                                                                                                               |  |               |         |   |                   |   |         |  
|Total liabilities                                                                                                                                                              |  |               | 265,904 |   |                   |   | 17,795  |  
|                                                                                                                                                                               |  |               |         |   |                   |   |         |  
|Commitments and Contingencies                                                                                                                                                  |  |               |         |   |                   |   |         |  
|                                                                                                                                                                               |  |              
|Stockholders equity:                                                                                                                                                          |  |               |         |   |                   |   |         |  
|Preferred stock, par value $0.001 per share. 5,000,000 shares authorized; Series A convertible participating preferred stock; no shares issued
and outstanding                 |  |               |        |   |                   |   |        |  
|Series A junior participating preferred stock, par value $0.001 per share. 200,000 shares designated; no shares issued and
outstanding                                         |  |               |        |   |                   |   |        |  
|Common stock, par value $0.002 per share. 100,000,000 shares authorized; issued and outstanding 69,792,027 shares at March 31, 2007 and
69,769,886 shares at December 31, 2006 |  |               | 140     |   |                   |   | 140     |  
|Additional paid-in capital                                                                                                                                                     |  |               | 487,068 |   |                   |   | 508,436 |  
|Accumulated other comprehensive income                                                                                                                                         |  |               | 189     |   |                   |   | 57      |  
|Accumulated deficit                                                                                                                                                            |  |               | (74,676 | ) |                   |   | (96,734 | )
|                                                                                                                                                                               |  |               |         |   |                   |   |         |  
|Total stockholders equity                                                                                                                                                     |  |               | 412,721 |   |                   |   | 411,899 |  
|                                                                                                                                                                               |  |               |         |   |                   |   |         |  
|Total liabilities and stockholders equity                                                                                                                                     |  | $             | 678,625 |   |                   | $ | 429,694 |  
|                                                                                                                                                                               |  |               |         |   |                   |   |         |  

See accompanying notes to unaudited consolidated financial statements.



3



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ViroPharma Incorporated

Consolidated Statements of Operations

(unaudited)



|                                               |  |                              |        |   |      |   |        |  
|---------------------------------------------- |  | ---------------------------- | ------ | - | ---- | - | ------ | -
|                                               |  | Three months ended March 31, |       
|(in thousands, except per share data)          |  | 2007                         |        |   | 2006 |  
|Revenues:                                      |  |                              |        |   |      |   |        |  
|Net product sales                              |  | $                            | 49,029 |   |      | $ | 29,233 |  
|License fee and milestone revenue              |  |                              |       |   |      |   | 141    |  
|                                               |  |                              |        |   |      |   |        |  
|Total revenues                                 |  |                              | 49,029 |   |      |   | 29,374 |  
|                                               |  |                              |        |   |      |   |        |  
|Costs and Expenses:                            |  |                              |        |   |      |   |        |  
|Cost of sales                                  |  |                              | 2,230  |   |      |   | 5,674  |  
|Research and development                       |  |                              | 5,529  |   |      |   | 3,660  |  
|Marketing, general and administrative          |  |                              | 6,973  |   |      |   | 5,320  |  
|Intangible amortization                        |  |                              | 1,376  |   |      |   | 1,275  |  
|                                               |  |                              |        |   |      |   |        |  
|Total costs and expenses                       |  |                              | 16,108 |   |      |   | 15,929 |  
|                                               |  |                              |        |   |      |   |        |  
|Operating income                               |  |                              | 32,921 |   |      |   | 13,445 |  
|                                               |  |                             
|Other Income (Expense):                        |  |                              |        |   |      |   |        |  
|Loss on bond redemption                        |  |                              |       |   |      |   | (1,127 | )
|Interest income                                |  |                              | 3,580  |   |      |   | 2,222  |  
|Interest expense                               |  |                              | (92    | ) |      |   | (865   | )
|                                               |  |                              |        |   |      |   |        |  
|Income before income tax expense               |  |                              | 36,409 |   |      |   | 13,675 |  
|                                               |  |                             
|Income tax expense                             |  |                              | 14,351 |   |      |   | 5,487  |  
|                                               |  |                              |        |   |      |   |        |  
|Net income                                     |  | $                            | 22,058 |   |      | $ | 8,188  |  
|                                               |  |                              |        |   |      |   |        |  
|Net income per share:                          |  |                              |        |   |      |   |        |  
|Basic                                          |  | $                            | 0.32   |   |      | $ | 0.12   |  
|Diluted                                        |  | $                            | 0.31   |   |      | $ | 0.12   |  
|                                               |  |                             
|Shares used in computing net income per share: |  |                              |        |   |      |   |        |  
|Basic                                          |  |                              | 69,769 |   |      |   | 68,565 |  
|Diluted                                        |  |                              | 71,547 |   |      |   | 70,268 |  

See accompanying notes to unaudited consolidated financial statements.



4



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ViroPharma Incorporated

Consolidated Statements of Stockholders Equity

(unaudited)



|                                                                    |  |                 |  |              |   |                 |        |        |   |                          |  |   |                                     |   |                    |   |     |                          |   |         |   |  |   |         |  
|------------------------------------------------------------------- |  | --------------- |  | ------------ | - | --------------- | ------ | ------ | - | ------------------------ |  | - | ----------------------------------- | - | ------------------ | - | --- | ------------------------ | - | ------- | - |  | - | ------- | -
|                                                                    |  | Preferred Stock |  | Common Stock |   |                 |        |        |   |                          |  |   |                                     |   |                   
|(in thousands)                                                      |  | Numberof shares |  | Amount       |   | Numberof shares |        | Amount |   | Additionalpaid-incapital |  |   | Accumulatedothercomprehensiveincome |   | Accumulateddeficit |   |     | Totalstockholdersequity |  
|Balance, December 31, 2006                                          |  |                |  | $            |  |                 | 69,770 |        | $ | 140                      |  | $ | 508,436                             |   |                    | $ | 57  |                          | $ | (96,734 | ) |  | $ | 411,899 |  
|Exercise of common stock options                                    |  |                |  |              |  |                 | 22     |        |   |                         |  |   | 244                                 |   |                    |   |    |                          |   |        |   |  |   | 244     |  
|Issuance of common stock                                            |  |                |  |              |  |                 |       |        |   |                         |  |   | 11                                  |   |                    |   |    |                          |   |        |   |  |   | 11      |  
|Share-based compensation                                            |  |                |  |              |  |                 |       |        |   |                         |  |   | 1,588                               |   |                    |   |    |                          |   |        |   |  |   | 1,588   |  
|Cost of call spread options, net                                    |  |                |  |              |  |                 |       |        |   |                         |  |   | (23,250                             | ) |                    |   |    |                          |   |        |   |  |   | (23,250 | )
|Unrealized gain on available for sale securities, net of income tax |  |                |  |              |  |                 |       |        |   |                         |  |   |                                    |   |                    |   | 132 |                          |   |        |   |  |   | 132     |  
|Stock option tax benefits                                           |  |                |  |              |  |                 |       |        |   |                         |  |   | 39                                  |   |                    |   |    |                          |   |        |   |  |   | 39      |  
|Net income                                                          |  |                |  |              |  |                 |       |        |   |                         |  |   |                                    |   |                    |   |    |                          |   | 22,058  |   |  |   | 22,058  |  
|                                                                    |  |                 |  |              |   |                 |        |        |   |                          |  |   |                                     |   |                    |   |     |                          |   |         |   |  |   |         |  
|Balance, March 31, 2007                                             |  |                |  | $            |  |                 | 69,792 |        | $ | 140                      |  | $ | 487,068                             |   |                    | $ | 189 |                          | $ | (74,676 | ) |  | $ | 412,721 |  
|                                                                    |  |                 |  |              |   |                 |        |        |   |                          |  |   |                                     |   |                    |   |     |                          |   |         |   |  |   |         |  

See accompanying notes to unaudited consolidated financial statements.



5



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ViroPharma Incorporated

Consolidated Statements of Cash Flows

(unaudited)



|                                                                                  |  |                             |          |   |      |   |          |  
|--------------------------------------------------------------------------------- |  | --------------------------- | -------- | - | ---- | - | -------- | -
|                                                                                  |  | Three months endedMarch 31, |         
|(in thousands)                                                                    |  | 2007                        |          |   | 2006 |  
|Cash flows from operating activities:                                             |  |                             |          |   |      |   |          |  
|Net income                                                                        |  | $                           | 22,058   |   |      | $ | 8,188    |  
|Adjustments to reconcile net income to net cash provided by operating activities: |  |                             |          |   |      |   |          |  
|Loss on bond redemption                                                           |  |                             |         |   |      |   | 1,127    |  
|Non-cash share-based compensation expense                                         |  |                             | 1,588    |   |      |   | 929      |  
|Non-cash interest expense                                                         |  |                             | 13       |   |      |   | 75       |  
|Deferred tax provision                                                            |  |                             | 5,787    |   |      |   | 2,232    |  
|Depreciation and amortization expense                                             |  |                             | 1,576    |   |      |   | 1,388    |  
|Changes in assets and liabilities:                                                |  |                             |          |   |      |   |          |  
|Accounts receivable                                                               |  |                             | (13,536  | ) |      |   | 1,177    |  
|Inventory                                                                         |  |                             | (1,011   | ) |      |   | 729      |  
|Other current assets                                                              |  |                             | 546      |   |      |   | (703     | )
|Other assets                                                                      |  |                             | 49       |   |      |   |         |  
|Accounts payable                                                                  |  |                             | (75      | ) |      |   | (5,497   | )
|Due to partners                                                                   |  |                             | 250      |   |      |   |         |  
|Accrued expenses and other current liabilities                                    |  |                             | (3,642   | ) |      |   | (8,825   | )
|Deferred revenue                                                                  |  |                             | (274     | ) |      |   | (141     | )
|Income taxes receivable/payable                                                   |  |                             | 1,296    |   |      |   | 2,881    |  
|Other liabilities                                                                 |  |                             |         |   |      |   | 181      |  
|                                                                                  |  |                             |          |   |      |   |          |  
|Net cash provided by operating activities                                         |  |                             | 14,625   |   |      |   | 3,741    |  
|                                                                                  |  |                            
|Cash flows from investing activities:                                             |  |                             |          |   |      |   |          |  
|Purchase of property, plant and equipment                                         |  |                             | (8,409   | ) |      |   | (1,277   | )
|Purchases of short-term investments                                               |  |                             | (178,597 | ) |      |   | (401,176 | )
|Maturities of short-term investments                                              |  |                             | 154,040  |   |      |   | 331,789  |  
|                                                                                  |  |                             |          |   |      |   |          |  
|Net cash (used in) investing activities                                           |  |                             | (32,966  | ) |      |   | (70,664  | )
|                                                                                  |  |                            
|Cash flows from financing activities:                                             |  |                             |          |   |      |   |          |  
|Net proceeds from the issuance of senior convertible notes                        |  |                             | 241,825  |   |      |   |         |  
|Net purchase of call spread transactions                                          |  |                             | (23,250  | ) |      |   |         |  
|Redemption of subordinated convertible notes                                      |  |                             |         |   |      |   | (79,596  | )
|Net proceeds from issuance of common stock                                        |  |                             | 255      |   |      |   | 6        |  
|Excess tax benefits from share-based payment arrangements                         |  |                             | 39       |   |      |   | 164      |  
|                                                                                  |  |                             |          |   |      |   |          |  
|Net cash provided by (used in) financing activities                               |  |                             | 218,869  |   |      |   | (79,426  | )
|                                                                                  |  |                            
|Net increase (decrease) in cash and cash equivalents                              |  |                             | 200,528  |   |      |   | (146,349 | )
|                                                                                  |  |                            
|Cash and cash equivalents at beginning of period                                  |  |                             | 51,524   |   |      |   | 232,195  |  
|                                                                                  |  |                             |          |   |      |   |          |  
|Cash and cash equivalents at end of period                                        |  | $                           | 252,052  |   |      | $ | 85,846   |  
|                                                                                  |  |                             |          |   |      |   |          |  

See accompanying notes to unaudited consolidated financial statements.



6



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements



Note 1. Organization and Business Activities

ViroPharma Incorporated and subsidiaries (ViroPharma or the Company) is a biopharmaceutical company dedicated to the development and commercialization of products that address serious
infectious diseases, with a focus on products used by physician specialists or in hospital settings. The Company intends to grow through sales of its marketed product, Vancocin, through continued development of its product pipeline and through
potential acquisition or licensing of products or acquisition of companies.

ViroPharma has one marketed product and multiple product candidates in
clinical development. The Company markets and sells Vancocin HCl capsules, the oral capsule formulation of vancomycin hydrochloride, in the U.S. and its territories. Vancocin is a potent antibiotic approved by the U.S. Food and Drug Administration,
or FDA, to treat antibiotic-associated pseudomembranous colitis caused by Clostridium difficile, or C. difficile, and enterocolitis caused by Staphylococcus aureus, including methicillin-resistant strains.

ViroPharma is developing maribavir for the treatment of cytomegalovirus, or CMV, infection and HCV-796 for the treatment of hepatitis C virus, or HCV, infection. The
Company has licensed the U.S. and Canadian rights for a third product candidate, an intranasal formulation of pleconaril, to Schering-Plough for the treatment of picornavirus infections.

Basis of Presentation

The consolidated financial information at March 31, 2007 and for the three months ended
March 31, 2007 and 2006, is unaudited but includes all adjustments (consisting only of normal recurring adjustments) which, in the opinion of management, are necessary to state fairly the consolidated financial information set forth therein in
accordance with accounting principles generally accepted in the United States of America. The interim results are not necessarily indicative of results to be expected for the full fiscal year. These unaudited consolidated financial statements should
be read in conjunction with the audited consolidated financial statements for the year ended December 31, 2006 included in the Companys Annual Report on Form 10-K filed with the Securities and Exchange Commission.

Adoption of Standards

In July 2006, the FASB issued FASB
Interpretation No. 48, Accounting for Uncertain Tax Positions, (FIN 48) to clarify the criteria for recognizing tax benefits related to uncertain tax positions under SFAS No. 109, Accounting for Income Taxes, and
to require additional financial statement disclosure. FIN 48 requires that the Company recognize in its consolidated financial statements, the impact of a tax position if that position is more likely than not to be sustained upon examination, based
on the technical merits of the position. Adoption of FIN 48 as of January 1, 2007 is reflected in Note 8.

In September 2006, the FASB issued FASB
Staff Position (FSP) AUG AIR-1, Accounting for Planned Major Maintenance Activities, that prohibits the use of the accrue-in-advance method of accounting for planned major maintenance activities. The Company adopted this FSP as of
January 1, 2007 with no impact on operating results or financial position.

Reclassification

Certain prior year amounts have been reclassified to conform to the current year presentation. Specifically, certain expenses were reclassified within operating expenses.



7



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements (continued)



Note 2. Short-Term Investments

Short-term investments consist of fixed income securities with remaining maturities of greater than three months at the date of purchase and debt securities. At March 31, 2007 and December 31, 2006, all of
the investments were classified as available for sale investments.

The following summarizes the available for sale investments at March 31, 2007 and
December 31, 2006:



|                                             |  |      |         |                      |   |                       |  |            |     |  |   |        
|-------------------------------------------- |  | ---- | ------- | -------------------- | - | --------------------- |  | ---------- | --- |  | - | -------
|(in thousands)                               |  | Cost |         | Grossunrealizedgains |   | Grossunrealizedlosses |  | Fair value
|March 31, 2007                               |  |      |         |                      |   |                       |  |            |     |  |   |        
|Certificates of deposit                      |  | $    | 300     |                      | $ |                      |  | $          |    |  | $ | 300    
|Debt securities:                             |  |      |         |                      |   |                       |  |            |     |  |   |        
|US Treasury and other US Government Agencies |  |      | 71,463  |                      |   | 2                     |  |            | 92  |  |   | 71,373 
|Foreign Governments                          |  |      | 34,761  |                      |   | 451                   |  |            | 20  |  |   | 35,192 
|Corporate                                    |  |      | 121,765 |                      |   | 4                     |  |            | 60  |  |   | 121,709
|                                             |  |      |         |                      |   |                       |  |            |     |  |   |        
|                                             |  | $    | 228,289 |                      | $ | 457                   |  | $          | 172 |  | $ | 228,574
|                                             |  |      |         |                      |   |                       |  |            |     |  |   |        
|Maturities of investments were as follows:   |  |      |         |                      |   |                       |  |            |     |  |   |        
|Less than one year                           |  | $    | 228,289 |                      | $ | 457                   |  | $          | 172 |  | $ | 228,574
|                                             |  |      |         |                      |   |                       |  |            |     |  |   |        
|December 31, 2006                            |  |      |         |                      |   |                       |  |            |     |  |   |        
|Certificates of deposit                      |  | $    | 300     |                      | $ |                      |  | $          |    |  | $ | 300    
|Debt securities:                             |  |      |         |                      |   |                       |  |            |     |  |   |        
|US Treasury and other US Government Agencies |  |      | 46,430  |                      |   | 12                    |  |            | 41  |  |   | 46,401 
|Foreign Governments                          |  |      | 44,494  |                      |   | 225                   |  |            | 32  |  |   | 44,687 
|Corporate                                    |  |      | 112,577 |                      |   | 16                    |  |            | 96  |  |   | 112,497
|                                             |  |      |         |                      |   |                       |  |            |     |  |   |        
|                                             |  | $    | 203,801 |                      | $ | 253                   |  | $          | 169 |  | $ | 203,885
|                                             |  |      |         |                      |   |                       |  |            |     |  |   |        
|Maturities of investments were as follows:   |  |      |         |                      |   |                       |  |            |     |  |   |        
|Less than one year                           |  | $    | 203,801 |                      | $ | 253                   |  | $          | 169 |  | $ | 203,885
|                                             |  |      |         |                      |   |                       |  |            |     |  |   |        

Note 3. Inventory

Inventory is related to Vancocin and is stated at the lower of cost or market using the first-in first-out method. The following represents the components of the inventory at March 31, 2007 and December 31, 2006:



|               |  |               |       |                  |   |      
|-------------- |  | ------------- | ----- | ---------------- | - | -----
|(in thousands) |  | March 31,2007 |       | December 31,2006
|Raw Materials  |  | $             | 3,510 |                  | $ | 3,273
|Finished Goods |  |               | 2,261 |                  |   | 1,487
|               |  |               |       |                  |   |      
|Total          |  | $             | 5,771 |                  | $ | 4,760
|               |  |               |       |                  |   |      



8



---

ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements (continued)



Note 4. Intangible Assets

The following represents the balance of the intangible assets at March 31, 2007:



|                      |  |                       |         |                         |   |                      |  |   |        
|--------------------- |  | --------------------- | ------- | ----------------------- | - | -------------------- |  | - | -------
|(in thousands)        |  | GrossIntangibleAssets |         | AccumulatedAmortization |   | Net IntangibleAssets
|Trademarks            |  | $                     | 12,039  |                         | $ | 1,150                |  | $ | 10,889 
|Know-how              |  |                       | 84,272  |                         |   | 8,053                |  |   | 76,219 
|Customer relationship |  |                       | 38,198  |                         |   | 3,650                |  |   | 34,548 
|                      |  |                       |         |                         |   |                      |  |   |        
|Total                 |  | $                     | 134,509 |                         | $ | 12,853               |  | $ | 121,656
|                      |  |                       |         |                         |   |                      |  |   |        

The following represents the balance of the intangible assets at December 31, 2006:



|                      |  |                       |         |                         |   |                      |  |   |        
|--------------------- |  | --------------------- | ------- | ----------------------- | - | -------------------- |  | - | -------
|(in thousands)        |  | GrossIntangibleAssets |         | AccumulatedAmortization |   | Net IntangibleAssets
|Trademarks            |  | $                     | 12,007  |                         | $ | 1,027                |  | $ | 10,980 
|Know-how              |  |                       | 84,046  |                         |   | 7,192                |  |   | 76,854 
|Customer relationship |  |                       | 38,096  |                         |   | 3,258                |  |   | 34,838 
|                      |  |                       |         |                         |   |                      |  |   |        
|Total                 |  | $                     | 134,149 |                         | $ | 11,477               |  | $ | 122,672
|                      |  |                       |         |                         |   |                      |  |   |        

In March 2006, as a result of OGDs change in approach relating to generic bioequivalence determinations, we
reviewed the value of the intangible asset and concluded that there was no impairment of the carrying value of the intangible assets or change to the useful lives as estimated at the acquisition date. Additionally, on an ongoing periodic basis, we
evaluate the useful life of these intangible assets and determine if any economic, governmental or regulatory event has modified their estimated useful lives. This evaluation did not result in a change the life of the intangible assets during the
quarter ended March 31, 2007. We will continue to monitor the actions of the OGD and consider the effects of our opposition efforts and the announcements by generic competitors or other adverse events for additional impairment indicators and we
will reevaluate the expected cash flows and fair value of our Vancocin-related assets, as well as estimated useful lives, at such time.

In the event the
OGDs revised approach for Vancocin remains in effect, the time period in which a generic competitor may enter the market would be reduced. This could result in a reduction to the useful life of the Vancocin-related intangible assets.
Management currently believes there are no indicators that would require a change in useful life as management believes that Vancocin will continue to be utilized along with generics that may enter the market.

A reduction in the useful life, as well as the timing and number of generics, will impact our cash flow assumptions and estimate of fair value, perhaps to a level that
could result in an impairment charge. The Company will continue to monitor the actions of the OGD and consider the effects of our opposition actions and the announcements by generic competitors or other adverse events for additional impairment
indicators and will reevaluate the expected cash flows and fair value of our Vancocin-related assets at such time.

The Company is obligated to pay Eli
Lilly and Company (Lilly) additional purchase price consideration based on net sales of Vancocin within a calendar year. The additional purchase price consideration is determined by the annual net sales of Vancocin, is paid quarterly and
is due each year through 2011. The Company accounts for these additional payments as additional purchase price in accordance with SFAS No. 141, Business Combinations, which requires that the additional purchase price consideration is
recorded as an increase to the intangible assets of Vancocin, is allocated over the asset classifications described above and is amortized over the remaining estimated useful life of the intangible assets. In addition, at the time of recording the
additional intangible assets, a cumulative adjustment is recorded to accumulated intangible amortization, in addition to ordinary amortization expense, in order to reflect amortization as if the additional purchase price had been paid in November
2004.

As of March 31, 2007, the Company has paid an aggregate of $17.1 million to Lilly in additional purchase price consideration, as net sales of
Vancocin surpassed the maximum obligation level of $65 million in 2005 and 2006. The $17.1 million payment was based upon 35% of $19 million in 2006 and 50% of $21 million in 2005. The Company accrued



9



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements (continued)



approximately $360,000 of additional purchase price for the first quarter of 2007 as net sales of Vancocin surpassed the minimum obligation level of $48
million. The Company is obligated to pay Lilly additional amounts based on annual net sales of Vancocin as set forth below:



|                  |  |                                                
|----------------- |  | -----------------------------------------------
|2007              |  | 35% payment on net sales between $48-65 million
|2008 through 2011 |  | 35% payment on net sales between $45-65 million

No additional payments are due to Lilly on net sales of Vancocin below or above the net sales levels reflected in
the above table.

Note 5. Property, Plant and Equipment

The increase in property, plant and equipment is primarily related to the purchase of the Companys corporate headquarters in Exton, Pennsylvania for $7.65 million, which was funded from available cash. On January 30, 2007, the
purchase was finalized and the operating lease was terminated. In connection with recording the acquisition of the building, the Company reduced the cost of the building by $0.5 million, which represented deferred rent, previously included as a
current liability as of December 31, 2006.

Note 6. Long-Term Debt

On March 26, 2007, the Company issued $250.0 million of 2% senior convertible notes due March 2017 (the senior convertible notes) in a public offering. The $250.0 million includes an issuance pursuant to
the underwriters exercise of an overalloment in the amount of $25.0 million that was closed concurrently on March 26, 2007. Net proceeds from the issuance of the senior convertible notes were $241.8 million. The senior convertible notes are
unsecured unsubordinated obligations and rank equally with any other unsecured and unsubordinated indebtedness. Debt issuance costs of $8.2 million have been capitalized and are being amortized over the term of the senior convertible notes. The
senior convertible notes are convertible into shares of the Companys common stock at an initial conversion price of $18.87 per share. The senior convertible notes bear interest at a rate of 2% per annum, payable semi-annually in arrears
on March 15 and September 15 of each year commencing on September 15, 2007. The senior convertible notes may only be converted: (i) anytime after December 15, 2016; (ii) during the five business-day period after any
five consecutive trading day period (the measurement period) in which the price per note for each trading day of that measurement period was less than 98% of the product of the last reported sale price of our common stock and the
conversion rate on each such day; (iii) during any calendar quarter (and only during such quarter) after the calendar quarter ending June 30, 2007, if the last reported sale price of our common stock for 20 or more trading days in a period
of 30 consecutive trading days ending on the last trading day of the immediately preceding calendar quarter exceeds 130% of the applicable conversion price in effect on the last trading day of the immediately preceding calendar quarter; or
(iv) upon the occurrence of specified corporate events. Upon conversion, holders of the senior convertible notes will receive shares of common stock, subject to ViroPharmas option to irrevocably elect to settle all future conversions in
cash up to the principal amount of the senior convertible notes, and shares for any excess. The senior convertible notes may be required to be repaid on the occurrence of certain fundamental changes, as defined in the senior convertible notes. As of
March 31, 2007, the fair value of the $250.0 million convertible senior notes outstanding was approximately $254.7 million, based on the quoted market price.

Concurrent with the issuance of the senior convertible notes the Company purchased call options on its common stock in private transactions with Credit Suisse International, Credit Suisse, New York Branch, as agent
for Credit Suisse International, and Wells Fargo Bank, National Association (the call spread holders). The call options allow ViroPharama to receive up to approximately 13.25 million shares of its common stock at $18.87 from the
call spread holders, equal to the amount of common stock related to the excess conversion value that ViroPharama would pay to the holders of the senior convertible notes upon conversion. These call options will terminate upon the earlier of the
maturity dates of the related senior convertible notes or the first day all of the related senior convertible notes are no longer outstanding due to conversion or otherwise. The cost of the call options, approximately $92.3 million, was recorded as
a reduction to additional paid-in-capital.

In a separate transaction with the issuance of the senior convertible notes, ViroPharma sold warrants to
Goldman Sachs and Credit Suisse (the call spread holders) to issue shares of its common stock at an exercise price of $24.92 per share. Pursuant to this transaction, warrants for approximately 13.25 million shares of
ViroPharmas common stock were issued. Proceeds received from the issuance of the warrants totaled approximately $69.0 million and were recorded as an increase to additional paid-in-capital. If we have insufficient shares of common stock
available for settlement of the warrants, we may



10



---

ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements (continued)



issue shares of a newly created series of preferred stock in lieu of our obligation to deliver common stock. Any such preferred stock would be convertible
into 10% more shares of our common stock than the amount of common stock we would otherwise have been obligated to deliver under the warrants.

Note 7.
Share-based Compensation

In accordance with Statement of Financial Accounting Standards No. 123 (revised 2004), Share-Based Payment
(SFAS 123R), the Company recorded share-based compensation expense for the first quarter of 2007 and 2006 of $1.6 million and $0.9 million, respectively.



|                                      |  |                             |       |      |   |    
|------------------------------------- |  | --------------------------- | ----- | ---- | - | ---
|(in thousands)                        |  | Three monthsended March 31,
|                                      |  | 2007                        |       | 2006
|Research and development              |  | $                           | 454   |      | $ | 216
|Marketing, general and administrative |  |                             | 1,134 |      |   | 713
|                                      |  |                             |       |      |   |    
|Total                                 |  | $                           | 1,588 |      | $ | 929
|                                      |  |                             |       |      |   |    

Refer to Note 6 of the Companys 2006 Annual Report on Form 10-K for information on the valuation and
accounting for these plans.

Employee Stock Option Plans

The Company currently has three option plans in place: a 1995 Stock Option and Restricted Share Plan (1995 Plan), a 2001 Equity Incentive Plan (2001 Plan) and a 2005 Stock Option and Restricted Share Plan (2005
Plan) (collectively, the Plans).

The following table lists the balances available by Plan at March 31, 2007:



|                                            |  |            |   |  |           |   |  |            |   |  |            |  
|------------------------------------------- |  | ---------- | - |  | --------- | - |  | ---------- | - |  | ---------- | -
|                                            |  | 1995 Plan  |   |  | 2001 Plan |   |  | 2005 Plan  |   |  | Combined   |  
|Number of shares authorized                 |  | 4,500,000  |   |  | 500,000   |   |  | 2,850,000  |   |  | 7,850,000  |  
|Number of options granted since inception   |  | (6,997,515 | ) |  | (991,600  | ) |  | (1,707,820 | ) |  | (9,696,935 | )
|Number of options cancelled since inception |  | 2,930,533  |   |  | 759,837   |   |  | 102,550    |   |  | 3,792,920  |  
|Number of shares expired                    |  | (433,018   | ) |  |          |   |  |           |   |  | (433,018   | )
|                                            |  |            |   |  |           |   |  |            |   |  |            |  
|Number of shares available for grant        |  |           |   |  | 268,237   |   |  | 1,244,730  |   |  | 1,512,967  |  
|                                            |  |            |   |  |           |   |  |            |   |  |            |  

The Company issued 502,320 stock options in the first quarter of 2007. The fair value of each option grant was
estimated using the Black-Scholes option-pricing model using the following assumptions:



|                                         |  |              
|---------------------------------------- |  | -------------
|Expected dividend yield                  |  |             
|Range of risk free interest rate         |  | 4.6% - 5.1%  
|Weighted-average volatility              |  | 94.5%        
|Range of volatility                      |  | 94.5% - 94.6%
|Range of expected option life (in years) |  | 5.50  6.25  



11



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements (continued)



The Company has 4,368,392 million option grants outstanding at March 31, 2007 with exercise prices ranging
from $0.99 per share to $38.70 per share and a weighted average remaining contractual life of 7.34 years. The following table lists the outstanding and exercisable option grants as of March 31, 2007:



|            |  |                   |  |                                |       |                                                  |      |                                         |   |       
|----------- |  | ----------------- |  | ------------------------------ | ----- | ------------------------------------------------ | ---- | --------------------------------------- | - | ------
|            |  | Number of options |  | Weighted averageexercise price |       | Weighted averageremainingcontractual term(years) |      | Aggregate intrinsicvalue (in thousands)
|Outstanding |  | 4,368,392         |  | $                              | 10.54 |                                                  | 7.34 |                                         | $ | 25,067
|Exercisable |  | 2,168,310         |  | $                              | 10.34 |                                                  | 5.89 |                                         | $ | 14,759

As of March 31, 2007, there was $17.3 million of total unrecognized compensation cost related to unvested
share-based payments (including share options) granted under the Plans. That cost is expected to be recognized over a weighted-average period of 1.63 years.

Employee Stock Purchase Plan

The Company has an employee stock purchase plan. Under this plan, no shares were sold to employees during the
first quarter of 2007. During the years ended December 31, 2006 and 2005, 14,395 and 15,894 shares, respectively, were sold to employees. As of March 31, 2007 there are approximately 293,180 shares available for issuance under this plan.

Under this plan, there are two plan periods: January 1 through June 30 (Plan Period
One) and July 1 through December 31 (Plan Period Two). For Plan Period One in 2007, the fair value of $27.1 million was estimated using the Type B model provided by SFAS 123R, with a risk free interest rate of 4.9%,
volatility of 45.0% and an expected option life of 0.50 years. This fair value is being amortized over the six month period ending June 30, 2007.

Non-employee Stock Options

The Company remeasured the fair value of 9,000 options as of March 31, 2007, which resulted in no impact to
compensation expense in the first quarter of 2007. The fair value of the non-employee share options was estimated at $56,000 using the Black-Scholes option-pricing model, with a risk free interest rate ranging from 4.5% to 5.1%, volatility ranging
from 34.5% to 87.5%, weighted volatility of 70.5% and an expected option life ranging from 0.31 to 5.04 years.

There were no non-employee share options
vested or exercised during the quarter ended March 31, 2007 or 2006.

Note 8. Income Tax Expense

On January 1, 2007, the Company adopted FASB Interpretation No. 48, Accounting for Uncertainty in Income Taxes(FIN 48). FIN 48 clarifies the
criteria for recognizing tax benefits related to uncertain tax positions under SFAS No. 109, Accounting for Income Taxes, and requires additional financial statement disclosure. FIN 48 requires that the Company recognizes in its
consolidated financial statements, the impact of a tax position if that position is more likely than not to be sustained upon examination, based on the technical merits of the position. Adoption of FIN 48 had no impact on the Companys
consolidated results of operations and financial position.

Upon adoption, the Company identified $1.7 million of uncertain tax positions that the Company
currently does not believe meet the more likely than not recognition threshold under FIN 48 to be sustained upon examination. Since these uncertain tax positions have not been utilized and had a full valuation allowance established, the Company
reduced the gross deferred tax asset and valuation allowance by $1.7 million. This amount relates to unrecognized tax benefits that would impact the effective tax rate if recognized absent the valuation allowance. The Company does not expect any
material increase or decrease in tax benefit in the next twelve months related to examinations or uncertain tax positions.

The Company or one of its
subsidiaries files income tax returns in the U.S. federal jurisdiction and various states. The Company is subject to U.S. federal or state income tax examinations by tax authorities for years after 2001. During the periods open to examination, the
Company has utilized net operating loss and tax credit carry forwards that have attributes from closed periods. Since these NOLs and credit carry forwards were utilized in the open periods, they remain subject to examination.



12



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements (continued)



The Companys policy is to record interest and penalties on uncertain tax provisions as income tax expense. At
March 31, 2007, the Company has no uncertain tax provisions and no amounts recorded for interest or penalties included in the financial statements.

Note 9. Comprehensive Income (Loss)

In the Companys annual consolidated financial statements, comprehensive income (loss) is
presented as a separate financial statement. For interim consolidated financial statements, the Company is permitted to disclose the information in the footnotes to the consolidated financial statements. The disclosures are required for comparative
purposes. The only comprehensive income (loss) item the Company has is unrealized gains and losses on available for sale securities. The following reconciles net income (loss) to comprehensive income (loss) for the three months ended March 31,
2007 and 2006:



|                                                  |  |                             |        |      |   |      
|------------------------------------------------- |  | --------------------------- | ------ | ---- | - | -----
|(in thousands)                                    |  | Three months endedMarch 31,
|                                                  |  | 2007                        |        | 2006
|Net income                                        |  | $                           | 22,058 |      | $ | 8,188
|Other comprehensive:                              |  |                             |        |      |   |      
|Unrealized gains on available for sale securities |  |                             | 132    |      |   | 311  
|                                                  |  |                             |        |      |   |      
|Comprehensive income                              |  | $                           | 22,190 |      | $ | 8,499
|                                                  |  |                             |        |      |   |      

The unrealized gains are reported net of federal and state income taxes.

Note 10. Earnings per share



|                                                                    |  |                             |        |      |   |       
|------------------------------------------------------------------- |  | --------------------------- | ------ | ---- | - | ------
|(in thousands, except per share data)                               |  | Three months endedMarch 31,
|                                                                    |  | 2007                        |        | 2006
|Basic Earnings Per Share                                            |  |                             |        |      |   |       
|Net income                                                          |  | $                           | 22,058 |      | $ | 8,188 
|Common stock outstanding (weighted average)                         |  |                             | 69,769 |      |   | 68,565
|                                                                    |  |                             |        |      |   |       
|Basic net income per share                                          |  | $                           | 0.32   |      | $ | 0.12  
|                                                                    |  |                             |        |      |   |       
|Diluted Earnings Per Share                                          |  |                             |        |      |   |       
|Net income                                                          |  | $                           | 22,058 |      | $ | 8,188 
|Add interest expense on senior convertible notes, net of income tax |  |                             | 57     |      |   |      
|                                                                    |  |                             |        |      |   |       
|Diluted net income                                                  |  | $                           | 22,115 |      | $ | 8,188 
|Common stock outstanding (weighted average)                         |  |                             | 69,769 |      |   | 68,565
|Add shares from senior convertible notes                            |  |                             | 883    |      |   |      
|Add in-the-money stock options                                    |  |                             | 895    |      |   | 1,703 
|                                                                    |  |                             |        |      |   |       
|Common stock assuming conversion and stock option exercises         |  |                             | 71,547 |      |   | 70,268
|                                                                    |  |                             |        |      |   |       
|Diluted net income per share                                        |  | $                           | 0.31   |      | $ | 0.12  
|                                                                    |  |                             |        |      |   |       

The following common shares that are associated with stock options were excluded from the calculations as their
effect would be anti-dilutive:



|                       |  |                             |  |      
|---------------------- |  | --------------------------- |  | -----
|(in thousands)         |  | Three months endedMarch 31,
|                       |  | 2007                        |  | 2006 
|Common Shares Excluded |  | 573                         |  | 1,905



13



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ViroPharma Incorporated

Notes to the Unaudited Consolidated Financial Statements (continued)



Note 11. Supplemental Cash Flow Information



|                                                                        |  |                             |       |      |   |       |  
|----------------------------------------------------------------------- |  | --------------------------- | ----- | ---- | - | ----- | -
|                                                                        |  | Three months endedMarch 31, |      
|(in thousands)                                                          |  | 2007                        |       | 2006 |  
|Supplemental disclosure of non-cash transactions:                       |  |                             |       |      |   |       |  
|Employee share-based compensation                                       |  | $                           | 1,588 |      | $ | 978   |  
|Liability classified share-based compensation benefit                   |  |                             |      |      |   | (49   | )
|Unrealized gains on available for sale securities                       |  |                             | 132   |      |   | 311   |  
|Initial recognition of liability classified share-based awards          |  |                             |      |      |   | 116   |  
|Non-cash increase of intangible assets for Vancocin obligation to Lilly |  |                             | 360   |      |   |      |  
|Supplemental disclosure of cash flow information:                       |  |                             |       |      |   |       |  
|Cash paid for income taxes                                              |  | $                           | 7,299 |      | $ | 374   |  
|Cash paid for interest                                                  |  |                             |      |      |   | 2,368 |  
|Cash received for stock exercises and employee stock purchase plan      |  |                             | 255   |      |   |      |  



14



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|ITEM 2. | MANAGEMENTS DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
|------- | -------------------------------------------------------------------------------------

We are a biopharmaceutical company dedicated to the development and commercialization of products that address
serious infectious diseases, with a focus on products used by physician specialists or in hospital settings. We intend to grow through sales of our marketed product, Vancocin®HCl capsules, through the continued development of our product pipeline and through potential acquisition or licensing of products or
acquisition of companies

We have one marketed product and multiple product candidates in
development. We market and sell Vancocin®HCl capsules, the oral capsule formulation of
vancomycin hydrochloride, in the U.S. and its territories. Vancocin is a potent antibiotic approved by the U.S. Food and Drug Administration, or FDA, to treat antibiotic-associated pseudomembranous colitis caused by Clostridium difficile, or
C. difficile, and enterocolitis caused by S. aureus, including methicillin-resistant strains. We are developing maribavir for the prevention and treatment of cytomegalovirus, or CMV, disease, and HCV-796 for the treatment of hepatitis
C virus, or HCV, infection. We have licensed the U.S. and Canadian rights for a third product candidate, an intranasal formulation of pleconaril, to Schering-Plough for the treatment of picornavirus infections.

We intend to evaluate in-licensing or other opportunities to acquire products in development, or those that are currently on the market. We plan to seek products for
diseases treated by physician specialists and in hospital settings to complement the markets that we hope our CMV and HCV programs will serve or in which Vancocin is prescribed.

Executive Summary

Since the beginning of 2007, we experienced the following:

Business Activities

CMV:



| |  |  | Continued recruitment into an ongoing phase 3 study of maribavir in patients undergoing allogeneic stem cell transplant.
| | - |  | ------------------------------------------------------------------------------------------------------------------------

| |  |  | Prepared for a second phase 3 study of maribavir in solid organ transplant patients.
| | - |  | ------------------------------------------------------------------------------------

| |  |  | Announced, in May 2007, decision to commercialize maribavir in Europe, independent of strategic partners.
| | - |  | ---------------------------------------------------------------------------------------------------------

HCV (with our partner Wyeth):



| |  |  | Continued recruitment into a phase 2 study of HCV-796 when dosed in combination with pegylated interferon and ribavirin.
| | - |  | ------------------------------------------------------------------------------------------------------------------------

Vancocin:



| |  |  | Prescriptions continued to increase, with a 12.9% increase compared to the first quarter of 2006
| | - |  | ------------------------------------------------------------------------------------------------

Operating Results



| |  |  | Increased working capital by $241.3 million to $507.7 million, primarily as a result of the issuance of senior convertible notes.
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------



| |  |  | Increased net sales to $49.0 million, which was impacted by channel inventory reductions in 2006 compared to stable channel inventory in 2007.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------

Liquidity



| |  |  | Generated net cash from operating activities of $14.6 million.
| | - |  | --------------------------------------------------------------



| |  |  | Increased cash and cash equivalents and short-term investments by $225.2 million, primarily driven by the convertible debt offering which increased cash by $241.8
million, net of offering costs.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

During 2007 and going forward, we expect to face a number of challenges, which include the following:

The commercial sale of approved pharmaceutical products is subject to risks and uncertainties. There can be no assurance that future Vancocin sales will
meet or exceed the historical rate of sales for the product, for reasons that include, but are not limited to, generic and non-generic competition for Vancocin and/or changes in prescribing habits or disease incidence. Additionally, period over
period fluctuations in net product sales are expected to occur as a result of wholesaler buying decisions.



15



---

We cannot assure you that generic competitors will not take advantage of the absence of patent protection for Vancocin to
attempt to develop a competing product. We are not able to predict the time period in which a generic drug may enter the market. On March 17, 2006, we learned that the OGD changed its approach regarding the conditions that must be met in order
for a generic drug applicant to request a waiver of in-vivo bioequivalence testing for copies of Vancocin. We are opposing this attempt. However, in the event this change in approach remains in effect, the time period in which a generic competitor
may enter the market would be reduced and multiple generics may enter the market, which would materially impact our operating results, cash flows and asset valuations.

We will face intense competition in acquiring additional products to expand further our product portfolio. Many of the companies and institutions that we will compete with in acquiring additional products to expand
further our product portfolio have substantially greater capital resources, research and development staffs and facilities than we have, and substantially greater experience in conducting business development activities. We may need additional
financing in order to acquire new products in connection with our plans as described in this report.

The outcome of our clinical development programs are
subject to considerable uncertainties. We cannot be certain that we will be successful in developing and ultimately commercializing any of our product candidates in the timeframes that we expect, or at all.

We can not assure you that our current cash, cash equivalents and short-term investments or cash flows from Vancocin sales will be sufficient to fund all of our ongoing
development and operational costs over the next several years, that planned clinical trials can be initiated, or that planned or ongoing clinical trials can be successfully concluded or concluded in accordance with our anticipated schedule and
costs. Moreover, the results of our business development efforts could require considerable investments.

Our actual results could differ materially from
those results expressed in, or implied by, our expectations and assumption described in this Annual Report on Form 10-K. Please also see our discussion of the Risk Factors in Item 1A, which describe other important matters relating
our business.

Results of Operations

Three-months ended March 31, 2007 and 2006



|                                      |  |                                     |        |      |   |       
|------------------------------------- |  | ----------------------------------- | ------ | ---- | - | ------
|                                      |  | For the three months endedMarch 31,
|(in thousands, except per share data) |  | 2007                                |        | 2006
|Net product sales                     |  | $                                   | 49,029 |      | $ | 29,233
|Total revenues                        |  | $                                   | 49,029 |      | $ | 29,374
|Gross product margin                  |  | $                                   | 46,799 |      | $ | 23,559
|Operating income                      |  | $                                   | 32,921 |      | $ | 13,445
|Net income                            |  | $                                   | 22,058 |      | $ | 8,188 
|Net income per share:                 |  |                                     |        |      |   |       
|Basic                                 |  | $                                   | 0.32   |      | $ | 0.12  
|Diluted                               |  | $                                   | 0.31   |      | $ | 0.12  

The increases in net income relate primarily to increased net sales and increased gross margin rates, offset
primarily by increased development costs related to our CMV and HCV programs.



16



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Revenues

Revenues
consisted of the following:



|                                     |  |                                     |        |      |   |       
|------------------------------------ |  | ----------------------------------- | ------ | ---- | - | ------
|                                     |  | For the three months endedMarch 31,
|(in thousands)                       |  | 2007                                |        | 2006
|Net product sales                    |  | $                                   | 49,029 |      | $ | 29,233
|License fees and milestones revenues |  |                                     |       |      |   | 141   
|                                     |  |                                     |        |      |   |       
|Total revenues                       |  | $                                   | 49,029 |      | $ | 29,374
|                                     |  |                                     |        |      |   |       

RevenueVancocin product sales

Our net product sales are solely related to Vancocin. We sell Vancocin only to wholesalers who then distribute the product to pharmacies, hospitals and long-term care facilities, among others. Our sales of Vancocin
are influenced by wholesaler forecasts of prescription demand, wholesaler buying decisions related to their desired inventory levels, and, ultimately, end user prescriptions, all of which could be at different levels from period to period.

During the quarter ended March 31, 2007, net sales of Vancocin increased 67.7% compared to the same period in 2006 primarily due to an increase in
the number of units sold to wholesalers and the impact of price increases during 2007 and 2006. Our comparative period is also impacted by a decrease in wholesalers inventory levels during the 2006 period, as compared to the 2007 period where
wholesalers inventory remained relatively constant. Based upon data reported by IMS Health Incorporated, prescriptions during the quarter ended March 31, 2007 exceeded prescriptions in the 2006 period by 12.9%.

Approximately 92% of our sales are to three wholesalers. Vancocin product sales are influenced by prescriptions and wholesaler forecasts of prescription demand, which
could be at different levels from period to period. During the second quarter of 2006, we began receiving inventory data from two of our three largest wholesalers. We do not independently verify this data. Based on this inventory data, we believe as
of March 31, 2007, the wholesalers did not have excess channel inventory.

RevenueLicense fee and milestone revenues

License fee and milestone revenues in 2006 represent amortization of payments received under our agreement with Wyeth. There are no comparable amounts in 2007 as the
amortization period ended in December 2006.

Our license fee and milestone revenues result from existing or future collaborations of development-stage
products and currently vary greatly from period to period. See Liquidity, Operating Cash Inflows for additional information.



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Cost of sales and gross product margin



|                     |  |                                      |        |      |   |       
|-------------------- |  | ------------------------------------ | ------ | ---- | - | ------
|                     |  | For the three months ended
March 31,
|(in thousands)       |  | 2007                                 |        | 2006
|Net product sales    |  | $                                    | 49,029 |      | $ | 29,233
|Cost of sales        |  |                                      | 2,230  |      |   | 5,674 
|                     |  |                                      |        |      |   |       
|Gross product margin |  | $                                    | 46,799 |      | $ | 23,559
|                     |  |                                      |        |      |   |       

Vancocin cost of sales includes the cost of materials and distribution costs. Our gross product margin rate (net
product sales less cost of sales as a percent of net product sales) for Vancocin increased in the quarter ended March 31, 2007 to 95.5% from 80.6% in the same period in 2006, which included $2.1 million of additional costs. This increase
primarily results from the sale of units manufactured by OSG Norwich, which carry a lower inventory cost. The $2.1 million of additional costs in the first quarter of 2006 related to a portion of the November 2005 amendment to our manufacturing
agreement with Lilly whereby we increased the amount of Vancocin that Lilly supplied to us, which increased our cost of sales in the first quarter of 2006, as specific higher cost units were sold.

Since units are shipped based upon earliest expiration date, our actual margins will be impacted by the cost associated with the specific units that are sold.
Additionally, we may experience fluctuations in quarterly manufacturing yields and if this occurs, we would expect the cost of product sales of Vancocin, and accordingly, gross product margin percentage, to fluctuate from quarter to quarter.
Further, if we enter into fee-for-service or inventory management agreements with wholesalers in future periods, the fees would negatively impact our gross product margins.

Research and development expenses

For each of our research and development programs, we incur both direct and
indirect expenses. Direct expenses include third party costs related to these programs such as contract research, consulting, cost sharing payments or receipts, and preclinical and development costs. Indirect expenses include personnel, facility,
and other overhead costs. Due to recent advancements in our clinical development programs, we expect future costs to materially exceed current costs.

Research and development expenses were divided between our research and development programs in the following manner:



|                        |  |                                     |       |      |   |      
|----------------------- |  | ----------------------------------- | ----- | ---- | - | -----
|                        |  | For the three months endedMarch 31,
|(in thousands)          |  | 2007                                |       | 2006
|Direct  Core programs  |  |                                     |       |      |   |      
|CMV                     |  | $                                   | 2,957 |      | $ | 1,571
|HCV                     |  |                                     | 250   |      |   |     
|Vancocin / C. difficile |  |                                     | 112   |      |   | 427  
|Indirect                |  |                                     |       |      |   |      
|Development             |  |                                     | 2,210 |      |   | 1,662
|                        |  |                                     |       |      |   |      
|Total                   |  | $                                   | 5,529 |      | $ | 3,660
|                        |  |                                     |       |      |   |      

Direct ExpensesCore Development Programs

Related to our CMV program, during the first quarter of 2007 we continued recruitment into an ongoing phase 3 study of maribavir in patents undergoing allogeneic stem
cell transplant and prepared for a second phase 3 study of maribavir in solid organ transplant patients. During the first quarter of 2006 we concluded a preliminary analysis of data from our phase 2 clinical trial with maribavir and announced
positive preliminary results demonstrating that maribavir significantly reduces CMV reactivation in patients who had undergone allogeneic stem cell transplantation.

Related to our HCV program, costs in 2007 primarily represent those paid to Wyeth in connection with our cost-sharing arrangement related to discovery for screening compounds against HCV. Development activity for our
HCV product candidate, HCV-796, during the first quarter of 2007 included continued recruitment into a phase 2 study of HCV-796 when



18



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dosed in combination with pegylated interferon and ribavirin. During the first quarter of 2006, we initiated a phase 1b clinical trial of HCV-796 in
combination with pegylated interferon. Wyeth pays a substantial portion of the collaborations predevelopment and development expenses.

Related to
our Vancocin/C. difficile program, costs in 2007 and 2006 related to research and development activities, including costs related to non-toxigenic strains of C. difficile.

Anticipated fluctuations in future direct expenses are discussed under Liquidity  Development Programs.

Indirect Expenses

These costs primarily relate to the compensation of and overhead attributable to our development
team, primarily due to increased personnel.

Marketing, general and administrative expenses

Marketing, general and administrative expenses increased $1.7 million for the first quarter of 2007 as compared to the first quarter of 2006. The largest contributors to
this increase were legal and consulting costs ($0.7 million) and share-based compensation expense ($0.4 million). Other contributors included medical education, commercial related expenses, corporate franchise taxes, and business development costs,
which collectively increased by $0.4 million. Included in the increased legal and consulting costs are expenses incurred related to our opposition to the attempt by the OGD regarding the conditions that must be met in order for a generic drug
application to request a waiver of in-vivo bioequivalence testing for copies of Vancocin, which were $0.8 million in the first quarter of 2007 as compared to $0.4 million the same period in 2006. We anticipate that these additional legal and
consulting costs will continue at the current level, or possibly higher, in future periods as we continue this opposition. During 2007, we anticipate to continue to increase spending in marketing, general and administrative expenses, driven by these
additional legal and consulting costs, as well additional medical education expenses.

Intangible amortization and acquisition of technology rights

Intangible amortization is the result of the Vancocin product rights acquisition in the fourth quarter of 2004. Additionally, as described in our
agreement with Lilly, to the extent that we incur an obligation to Lilly for additional payments on Vancocin sales, we have contingent consideration. We record the obligation as an adjustment to the carrying amount of the related intangible asset
and a cumulative adjustment to the intangible amortization upon achievement of the related sales milestones. Contingent consideration and Lilly related additional payments are more fully described in Note 4 of the Unaudited Consolidated Financial
Statements.

Intangible amortization for the quarters ended March 31, 2007 and 2006 were comparable at $1.4 million and $1.3 million, respectively.
The first quarter of 2007 included approximately $35,000 for a cumulative adjustment, whereas the first quarter of 2006 did not include a cumulative adjustment.

In March 2006, as a result of OGDs change in approach relating to generic bioequivalence determinations, we reviewed the value of the intangible asset and concluded that there was no impairment of the carrying value of the intangible
assets or change to the useful lives as estimated at the acquisition date. Additionally, on an ongoing periodic basis, we evaluate the useful life of these intangible assets and determine if any economic, governmental or regulatory event has
modified their estimated useful lives. This evaluation did not result in a change the life of the intangible assets during the quarter ended March 31, 2007. We will continue to monitor the actions of the OGD and consider the effects of our
opposition efforts and the announcements by generic competitors or other adverse events for additional impairment indicators and we will reevaluate the expected cash flows and fair value of our Vancocin-related assets, as well as estimated useful
lives, at such time.



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Other Income (Expense)

Interest Income

Interest income for three months ended March 31, 2007 and 2006 was $3.6 million and $2.2 million. Interest income
increased primarily due to increased short-term investments during the 2007 period and to a lesser extent, an increased rate of return.

Interest
Expense



|                                                      |  |                                     |    |      |   |    
|----------------------------------------------------- |  | ----------------------------------- | -- | ---- | - | ---
|                                                      |  | For the three months endedMarch 31,
|(in thousands)                                        |  | 2007                                |    | 2006
|Interest expense on 2% senior convertible notes       |  | $                                   | 79 |      | $ |   
|Interest expense on 6% subordinated convertible notes |  |                                     |   |      |   | 790
|Amortization of finance costs                         |  |                                     | 13 |      |   | 75 
|                                                      |  |                                     |    |      |   |    
|Total interest expense                                |  | $                                   | 92 |      | $ | 865
|                                                      |  |                                     |    |      |   |    

Interest expense and amortization of finance costs in 2007 relates entirely to the senior convertible notes issued
on March 26, 2007, as described in Note 6 to the Unaudited Consolidated Financial Statements.

Interest expense and amortization of finance costs in
2006 relates entirely to the subordinated convertible notes, which were redeemed on March 1, 2006.

Income Tax Expense

Our effective income tax rate was 39.4% and 40.1% for the quarters ended March 31, 2007 and 2006, respectively. Our income tax expense includes federal and state
income tax at statutory rates and the effects of various permanent differences. The first quarter of 2006 also included the impact of adjustments to prior state apportionment rates. We currently anticipate an effective tax rate of 38.1% for the year
ended December 31, 2007. However, this may be reduced due to the orphan drug designation for maribavir received in February 2007, which has not been reflected in the financial statements as of March 31, 2007.

Liquidity

We expect that our near term sources of revenue will arise
from Vancocin product sales and milestone and license fee payments that we may receive from Wyeth and Schering-Plough if agreed upon events under our agreements with each of these companies are achieved. However, we cannot predict what the actual
sales of Vancocin will be in the future, the outcome of our effort to oppose the OGDs approach to bioequivalence determinations for generic copies of Vancocin is uncertain, and there are no assurances that the events that require payments to
us under the Wyeth and Schering-Plough arrangements will be achieved. In addition, there are no assurances that demand for Vancocin will continue at historical or current levels.

Our ability to generate positive cash flow is also impacted by the timing of anticipated events in our CMV and HCV programs, including results from clinical trials, the results of our product development efforts, and
variations from our estimate of future direct and indirect expenses.

While we anticipate that cash flows from Vancocin, as well as our current cash, cash
equivalents and short-term investments, should allow us to fund substantially all of our ongoing development and other operating costs, as well as the interest payable on the senior convertible notes, we may need additional financing in order to
expand our product portfolio. At March 31, 2007, we had cash, cash equivalents and short-term investments of $480.6 million. At March 31, 2007, the annualized weighted average nominal interest rate on our short-term investments was 5.14%.



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Overall Cash Flows

During the quarter ended March 31, 2007, we generated $14.6 million of net cash from operating activities, primarily from the cash contribution of Vancocin, which includes the impact on net income. Partially offsetting this cash
contribution is the impact of higher accounts receivables, which is related to the timing of orders and the price increase, and accrued expenses. We also used $33.0 million of cash for investing activities, as we purchased short-term investments and
our corporate headquarters building. Our net cash provided by financing activities for the quarter ended March 31, 2007 was $218.9 million, primarily from the March 2007 issuance of senior convertible notes, net of issuance costs, in the amount
of $241.8 million, partially offset by $23.3 million used to purchase the call spread as for fully described in Note 6 of the Unaudited Consolidated Financial Statements.

Operating Cash Inflows

We began to receive cash inflows from the sale of Vancocin in January 2005. We cannot
reasonably estimate the period in which we will begin to receive material net cash inflows from our product candidates currently under development. Cash inflows from development-stage products are dependent on several factors, including the
achievement of milestones and regulatory approvals. We may not receive milestone payments from any existing or future collaborations if a development-stage product fails to meet technical or performance targets or fails to obtain the required
regulatory approvals. Further, our revenues from collaborations will be affected by efforts of our collaborative partners. Even if we achieve technical success in developing drug candidates, our collaboration partners may not devote the resources
necessary to complete development and commence marketing of these products, when and if approved, or they may not successfully market these products. The most significant of our near-term operating development cash inflows are as described under
Development Programs.

Operating Cash Outflows

The cash flows we have used in operations historically have been applied to research and development activities, marketing and business development efforts, general and administrative expenses, servicing our debt, and
income tax payments. Bringing drugs from the preclinical research and development stage through phase 1, phase 2, and phase 3 clinical trials and FDA approval is a time consuming and expensive process. Because our product candidates are currently in
the clinical stage of development, there are a variety of events that could occur during the development process that will dictate the course we must take with our drug development efforts and the cost of these efforts. As a result, we cannot
reasonably estimate the costs that we will incur through the commercialization of any product candidate. However, due to recent advancements in our trials, we expect future costs to exceed current costs. The most significant of our near-term
operating development cash outflows are as described under Development Programs.

Development Programs

For each of our development programs, we incur both direct and indirect expenses. Direct expenses include third party costs related to these programs such as contract
research, consulting, cost sharing payments or receipts, and preclinical and clinical development costs. Indirect expenses include personnel, facility and other overhead costs. Additionally, for some of our development programs, we have cash inflows
and outflows upon achieving certain milestones.

Core Development Programs

CMV programFrom the date we in-licensed maribavir through March 31, 2007, we paid $25.1 million of direct costs in connection with this program, including the acquisition fee of $3.5 million paid to
GSK for the rights to maribavir in September 2003 and a $3.0 million milestone payment in February 2007.

During the remainder of 2007, we expect
maribavir-related activities to include continued recruitment into the ongoing phase 3 study in patients undergoing allogeneic stem cell transplant, as well as initiation of a phase 3 study in patients who have received a liver transplant. We will
also continue to conduct phase 1 clinical pharmacology studies to support the overall clinical development program. Based on the execution of phase 3 clinical development studies, we expect our expenses in 2007 for the CMV program to be
substantially higher than in 2006. We are solely responsible for the cost of developing our CMV product candidate.

In May 2007, we announced our decision
to pursue commercialization of maribavir in Europe, independent of strategic partners. We anticipate development expenses related to this initiative to increase significantly beginning in 2008.



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Should we achieve certain product development events, we are obligated to make certain milestone payments to GSK, the
licensor of maribavir.

HCV programFrom the date that we commenced predevelopment activities for compounds in this program that are currently
active through March 31, 2007, we paid $3.1 million in direct expenses for the predevelopment and development activities relating to such compounds. These costs are net of contractual cost sharing arrangements between Wyeth and us. Wyeth pays a
substantial portion of the collaborations predevelopment and development expenses.

During the remainder of 2007, the planned activities for our HCV
product candidate, HCV-796, include completion of enrollment in a phase 2 study of HCV-796 when dosed in combination with pegylated interferon and ribavirin. An additional cohort or cohorts may be added to the study at doses higher or lower than the
current 500 milligram BID dose to asses the dose/response relationship. We will also continue to conduct phase 1 clinical pharmacology studies to support the overall clinical development program. Depending on results of the phase 2 study, Wyeth and
we may initiate one or more clinical studies in early 2008. We have and expect to continue to conduct studies of HCV-796 in combination with other antiviral compounds. The results of the planned studies, along with other predevelopment activities
performed during the year, will significantly impact the timing and amount of expenses we will incur related to this program in future periods. In addition, discussions with the FDA regarding these studies may impact the timing, nature and cost of
future planned studies. Additionally, 2007 will continue to include costs associated with discovery activities as Wyeth and we renew some limited preclinical screening activity.

Should we achieve certain additional product development events, Wyeth is required to pay us certain cash milestones pursuant to terms of our collaboration agreement. However, there can be no assurances that we will
be successful in achieving these milestones.

Vancocin and C. difficile related We acquired Vancocin in November 2004 and through
March 31, 2007, we have spent approximately $0.4 million in direct research and development costs related to Vancocin or on related C. difficile activities.

During the remainder of 2007, we expect our research and development activities in the field of C. difficile to increase significantly, primarily related to our rights to develop non-toxigenic strains of C. difficile
for the treatment and prevention of CDAD. Therefore, we expect direct costs to increase above 2006 levels.

Direct ExpensesNon-Core Development
Programs

Common ColdFrom the date that we commenced predevelopment activities for the intranasal formulation of pleconaril through
December 31, 2004, we incurred $1.9 million in direct expenses. We have not incurred any significant direct expenses in connection with this program since 2004, nor will we in the future, as Schering-Plough has assumed responsibility for all
future development and commercialization of pleconaril.

In November 2004, we entered into a license agreement with Schering-Plough under which
Schering-Plough has assumed responsibility for all future development and commercialization of pleconaril. Schering-Plough paid us an initial license fee of $10.0 million in December 2004 and purchased our existing inventory of bulk drug substance
for an additional $6.0 million in January 2005. We will also be eligible to receive up to an additional $65.0 million in milestone payments upon achievement of certain targeted regulatory and commercial events, as well as royalties on
Schering-Ploughs sales of intranasal pleconaril in the licensed territories.

Business development activities

Through March 31, 2007, we paid an acquisition price of $116.0 million, paid $17.1 million related to additional purchase price consideration tied to product sales
(see Note 4 of the Unaudited Consolidated Financial Statements) and incurred $2.0 million of fees and expenses in connection with the Vancocin acquisition.

In addition, we intend to seek to acquire additional products or product candidates. The costs associated with evaluating or acquiring any additional product or product candidate can vary substantially based upon market size of the product,
the commercial effort required for the product, the products current stage of development, and actual and potential generic and non-generic competition for the product, among other factors. Due to the variability of the cost of evaluating or
acquiring business development candidates, it is not feasible to predict what our actual evaluation or acquisition costs would be, if any, however, the costs could be substantial.



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Senior Convertible Notes

On March 26, 2007, we issued $250.0 million principal amount of senior convertible notes due in March 2017. The senior convertible notes bear interest at a rate of 2% per annum, payable semi-annually in
arrears on March 15 and September 15 of each year commencing on September 15, 2007. The senior convertible notes are convertible into shares of the Companys common stock at an initial conversion price of $18.87 per share. Upon
conversion, holders of the senior convertible notes will receive shares of common stock, subject to ViroPharmas option to irrevocably elect to settle all future conversions in cash up to the principal amount of the senior convertible notes,
and shares for any excess. Prior to the conversion period, which begins on December 15, 2016, the senior convertible notes are convertible by the holder under specific criteria, as more fully described in Note 6 of the Unaudited Consolidated
Financial Statements.

Concurrent with the issuance of the senior convertible notes we purchased call options on our common stock in private transactions
with Credit Suisse International, Credit Suisse, New York Branch, as agent for Credit Suisse International, and Wells Fargo Bank, National Association (the call spread holders). The call options allow ViroPharama to receive up to
approximately 13.25 million shares of its common stock at $18.87 from the call spread holders, equal to the amount of common stock related to the excess conversion value that we would pay to the holders of the senior convertible notes upon
conversion. These call options will terminate upon the earlier of the maturity dates of the related senior convertible notes or the first day all of the related senior convertible notes are no longer outstanding due to conversion or otherwise. The
cost of the call options, approximately $92.3 million, was recorded as a reduction to additional paid-in-capital. The cost of call option for tax purposes creates a tax deduction since it is classified as Original Issue Discount (OID). The deduction
is considered a permanent difference and as such does not create a deferred tax asset. The benefit of deduction is recorded as an increase to additional paid-in-capital.

In a separate transaction with the issuance of the senior convertible notes, we sold warrants to Goldman Sachs and Credit Suisse (the call spread holders) to issue shares of our common stock at an exercise
price of $24.92 per share. Pursuant to this transaction, we issued warrants for approximately 13.25 million shares of our common stock. Proceeds received from the issuance of the warrants totaled approximately $69.0 million and were recorded as
an increase to additional paid-in-capital. If we have insufficient shares of common stock available for settlement of the warrants, we may issue shares of a newly created series of preferred stock in lieu of our obligation to deliver common stock.
Any such preferred stock would be convertible into 10% more shares of our common stock than the amount of common stock we would otherwise have been obligated to deliver under the warrants.

Capital Resources

We anticipate that cash flows from
Vancocin, as well as our current cash, cash equivalents and short-term investments, should allow us to fund substantially all of our ongoing development and other operating costs, as well as the interest payable on the senior convertible notes.
However, we may need additional financing in order to expand our product portfolio. Should we need financing, we would seek to access the public or private equity or debt markets, enter into additional arrangements with corporate collaborators to
whom we may issue equity or debt securities or enter into other alternative financing arrangements that may become available to us.

Financing

If we raise additional capital by issuing equity securities, the terms and prices for these financings may be much more favorable to the new investors
than the terms obtained by our existing stockholders. These financings also may significantly dilute the ownership of existing stockholders.

If we raise
additional capital by accessing debt markets, the terms and pricing for these financings may be much more favorable to the new lenders than the terms obtained from our prior lenders. These financings also may require liens on certain of our assets
that may limit our flexibility.

Additional equity or debt financing, however, may not be available on acceptable terms from any source as a result of,
among other factors, our operating results, our current indebtedness, our inability to achieve regulatory approval of any of our product candidates, our inability to generate revenue through our existing collaborative agreements, and our inability
to file, prosecute, defend and enforce patent claims and or other intellectual property rights. If sufficient additional financing is not available, we may need to delay, reduce or eliminate current development programs, or reduce or eliminate other
aspects of our business.



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Critical Accounting Policies

Our consolidated financial statements and accompanying notes are prepared in accordance with accounting principles generally accepted in the United States of America. Preparing consolidated financial statements requires us to make estimates
and assumptions that affect the reported amounts of assets, liabilities, revenues and expenses and contingent assets and liabilities. Actual results could differ from such estimates. These estimates and assumptions are affected by the application of
our accounting policies. Critical policies and practices are both most important to the portrayal of a companys financial condition and results of operations, and require managements most difficult, subjective or complex judgments, often
as a result of the need to make estimates about the effects of matters that are inherently uncertain.

Our summary of significant accounting policies is
described in Note 2 to our Consolidated Financial Statements included in this Form 10-K. However, we consider the following policies and estimates to be the most critical in understanding the more complex judgments that are involved in preparing our
consolidated financial statements and that could impact our results of operations, financial position, and cash flows:



| |  |  | Product SalesProduct revenue is recorded upon delivery to the wholesaler, when title has passed, price is determined and collectibility is reasonably assured.
At the end of each reporting period, as part of an analysis of returns, utilizing our revenue recognition policy (derived from the criteria of SEC Staff Accounting Bulletin No. 104, including Statement of Financial Accounting Standards
No. 48, Revenue Recognition When Right of Return Exists) we analyze our estimated channel inventory and we would defer recognition of revenue on product that has been delivered if we believe that channel inventory at a period
end is in excess of ordinary business needs and if we believe the value of potential returns is materially different than our returns accrual. Further, in connection with our analysis of returns, if we believe channel inventory levels are increasing
without a reasonably correlating increase in prescription demand, we proactively delay the processing of wholesaler orders until these levels are reduced.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We establish accruals for chargebacks and rebates, sales discounts and product returns. These accruals are primarily based upon the history of Vancocin,
including both Lilly and our ownership periods. We also consider the volume and price of our products in the channel, trends in wholesaler inventory, conditions that might impact patient demand for our product (such as incidence of disease and the
threat of generics) and other factors.

In addition to internal information, such as unit sales, we use information from external resources,
which we do not verify, to estimate the channel inventory. Our external resources include prescription data reported by IMS Health Incorporated and written and verbal information obtained from two of our three largest wholesaler customers with
respect to their inventory levels.

Chargebacks and rebates are the most subjective sales related accruals. While we currently have no
contracts with private third party payors, such as HMOs, we do have contractual arrangements with governmental agencies, including Medicaid. We establish accruals for chargebacks and rebates related to these contracts in the period in which we
record the sale as revenue. These accruals are based upon historical experience of government agencies market share, governmental contractual prices, our current pricing and then-current laws, regulations and interpretations. We analyze the
accrual at least quarterly and adjust the balance as needed. We believe that if our estimates of the rate of chargebacks and rebates as a percentage of annual gross sales were incorrect by 10%, our operating income and accruals would be impacted by
approximately $1.0 million in the period of correction.

In the first quarter of 2007, while continuing to monitor the implementation
process of Medicare Part D and consistent with our normal process, we performed an analysis on the share of Vancocin sales that ultimately go to Medicaid recipients and result in a Medicaid rebate. As part of that analysis, we considered our actual
Medicaid historical rebates processed, total units sold and fluctuations in channel inventory. As such, during the first quarter of 2007, we reduced our rebates accrual related to prior periods by approximately $0.4 million. While we anticipate that
our Medicaid rebate accrual should remain at this lower level based on actual experience since the implementation of Medicare Part D, the factors addressed above could ultimately result in a material impact on future periods.

Product returns are minimal. Product return accruals are estimated based on Vancocins history of damage and product expiration returns and are
recorded in the period in which we record the sale of revenue. At each reporting period, we also compare our returns accrual balance to the estimated channel inventory to ensure the accrual balance



24



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is reasonable and within an acceptable range. For example, if the estimated channel inventory is at a high level, we could be required to adjust our accrual
upward. We believe any adjustment would be immaterial.

Discounts are related to payment terms and are fully accrued in the period in which
we record the sale of revenue. Since our customers consistently take the payment discount, we do not believe that future periods will be materially impacted by a change in a previous discount accrual.



| |  |  | Impairment of Long-lived AssetsWe review our fixed and intangible assets for possible impairment whenever events occur or circumstances indicate that the
carrying amount of an asset may not be recoverable. Assumptions and estimates used in the evaluation of impairment may affect the carrying value of long-lived assets, which could result in impairment charges in future periods. Such assumptions
include, for example, projections of future cash flows and the timing and number of generic/competitive entries into the market, in determining the undiscounted cash flows, and if necessary, the fair value of the asset and whether an impairment
exists. These assumptions are subjective and could result in a material impact on operating results in the period of impairment. While we reviewed our intangible assets in March 2006 in light of the actions taken by the OGD, we did not recognize any
impairment charges. See Note 4 of the Unaudited Consolidated Financial Statements for further information. We will continue to monitor the actions of the OGD and consider the effects of our opposition actions and the announcements by generic
competitors or other adverse events for additional impairment indicators and we will reevaluate the expected cash flows and fair value of our Vancocin-related assets at such time.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

On an ongoing periodic basis, we evaluate the useful life of intangible assets and determine if any economic, governmental or regulatory event has
modified their estimated useful lives. While we reviewed the useful life of our intangible assets in March 2006 in light of the actions taken by the OGD, we have not changed the useful life of our intangible assets. See Note 4 of the Unaudited
Consolidated Financial Statements for further information.



| |  |  | Share-Based Employee CompensationWe adopted Statement of Financial Accounting Standards No. 123R, Share-based Payment, (SFAS 123R) effective
January 1, 2006. The calculation of this expense includes judgment related to the period of time used in calculating the volatility of our common stock, the amount of forfeitures and an estimate of the exercising habits of our employees, which
is also influenced by our Insider Trading Policy. Changes in the volatility of our common stock or the habits of our employees could result in variability in the fair value of awards granted.
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | Income TaxesOur annual effective tax rate is based on expected pre-tax earnings, existing statutory tax rates, limitations on the use of tax credits and net
operating loss carryforwards and tax planning opportunities available in the jurisdictions in which we operate. Significant judgment is required in determining our annual effective tax rate and in evaluating our tax position.
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

On a periodic basis, we evaluate the realizability of our deferred tax assets and liabilities and will adjust such
amounts in light of changing facts and circumstances, including but not limited to future projections of taxable income, tax legislation, rulings by relevant tax authorities, tax planning strategies and the progress of ongoing tax audits. We
recognize the benefit of tax positions that we have taken or expect to take on the income tax returns we file if such tax position is probable of being sustained. Settlement of filing positions that may be challenged by tax authorities could impact
the income tax position in the year of resolution. Our current tax liability is presented in the consolidated balance sheet within income taxes payable.

At March 31, 2007, we had $73.5 million of gross deferred tax assets, which included the effects of federal and state net operating loss (NOL) carryforwards of $37.0 million, capitalized research and
development costs of $26.5 million and other items of $10.0 million. These assets are offset by a $46.6 million valuation allowance as our ability to estimate long-term future taxable income with a high level of certainty is limited. In assessing
the realizability of deferred tax assets, we consider whether it is more likely than not that some portion or all of the deferred tax assets will not be realized. The ultimate realization of deferred tax assets is dependent upon the generation of
future taxable income during the period in which those temporary differences becomes deductible or the NOLs and credit carryforwards can be utilized. When considering the reversal of the valuation allowance, we consider the level of past and future
taxable income, the utilization of the carryforwards and other factors. Revisions to the estimated net realizable value of the deferred tax asset could cause our provision for income taxes to vary significantly from period to period. Should we
further reduce the valuation allowance of deferred tax assets, a current year tax benefit will be recognized and future periods would then include income taxes at a higher rate than the effective rate in the period that the adjustment is made.



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As our business evolves, we may face additional issues that will require increased levels of management estimation and
complex judgments.

Recently Issued Accounting Pronouncements

In September 2006, the FASB issued SFAS No. 157, Fair Value Measurements, (SFAS 157) that provides guidance on performing fair value measurements. It does not require new fair value measurements, although it could
change current practice for some companies. SFAS 157 is effective for fiscal years beginning after November 15, 2007. While we are currently evaluating the impact of SFAS 157 on our financial statements upon adoption, we do not anticipate a
material impact on operating results or financial position.

Off-Balance Sheet Arrangements

We do not have any off-balance sheet arrangements.



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|ITEM 3. | Quantitative and Qualitative Disclosures About Market Risk
|------- | ----------------------------------------------------------

Our
holdings of financial instruments are primarily comprised of a mix of U.S. corporate debt, government securities and commercial paper. All such instruments are classified as securities available for sale. Our debt security portfolio represents funds
held temporarily pending use in our business and operations. We manage these funds accordingly. Our primary investment objective is the preservation of principal, while at the same time maximizing the generation of investment income. We seek
reasonable assuredness of the safety of principal and market liquidity by investing in cash equivalents (such as Treasury bills and money market funds) and fixed income securities (such as U.S. government and agency securities, municipal securities,
taxable municipals, and corporate notes) while at the same time seeking to achieve a favorable rate of return. Our market risk exposure consists principally of exposure to changes in interest rates. Our holdings are also exposed to the risks of
changes in the credit quality of issuers. Historically, we have typically invested in financial instruments with maturities of less than one year. The carrying amount, which approximates fair value, and the annualized weighted average nominal
interest rate of our investment portfolio at March 31, 2007, was approximately $228.6 million and 5.14%, respectively. A one percent change in the interest rate would have resulted in a $0.6 million impact to interest income for the quarter
ended March 31, 2007.

Since 2006, we have also been exposed to movements in foreign currency exchange rates, specifically the Euro, for certain
immaterial expenses. We have used foreign currency forward exchange contracts based on forecasted transactions to reduce this exposure to the risk that the eventual net cash outflows, resulting from purchases from foreign testing sites, will be
adversely affected by changes in exchange rates. The nominal amount of these forwards as of March 31, 2007 was $0.4 million and the associated fair value was approximately $13,500, which is credited to research and development expenses.



|ITEM 4. | Controls and Procedures
|------- | -----------------------

Evaluation of Disclosure Controls and
Procedures

An evaluation was performed under the supervision and with the participation of our management, including our Chief Executive Officer, or
CEO, and our Chief Financial Officer, or CFO, of the effectiveness of our disclosure controls and procedures, as such term is defined under Rule 13a-15(e) promulgated under the Securities Exchange Act of 1934, as amended (the Exchange
Act), as of March 31, 2007. Based on that evaluation, our management, including our CEO and CFO, concluded that as of March 31, 2007 our disclosure controls and procedures were effective to ensure that information required to be
disclosed by us in reports that we file or submit under the Exchange Act, is recorded, processed, summarized and reported within the time periods specified in the rules and forms of the Securities and Exchange Commission and that such information is
accumulated and communicated to the Companys management, including our CEO and CFO, as appropriate to allow timely decisions regarding required disclosure.

Changes in Internal Control over Financial Reporting

During the first quarter of 2007 there were no significant changes in our internal
control over financial reporting identified in connection with the evaluation of such controls that occurred during our most recent fiscal quarter that has materially affected, or is reasonably likely to materially affect our internal control over
financial reporting.



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PART II - OTHER INFORMATION



|ITEM 1a. | Risk Factors
|-------- | ------------

We are providing the following information regarding
changes that have occurred to previously disclosed risk factors from our Annual Report on Form 10-K for the year ended December 31, 2006. In addition to the other information set forth below and elsewhere in this report, you should carefully
consider the factors discussed under the heading Risk Factors in our Form 10-K for the year ended December 31, 2006. The risks described in our Quarterly Reports on Form 10-Q are not the only risks facing our Company.
Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial also may materially adversely affect our business, financial condition and/or operating results.

Future sales of our common stock in the public market or issuances of our common stock pursuant to the terms of the senior convertible notes, outstanding options or
otherwise, could adversely affect our stock price.

We cannot predict the effect, if any, that future sales of our common stock or the availability for
future sale of shares of our common stock or securities convertible into or exercisable for our common stock will have on the market price of our common stock prevailing from time to time.

The conversion of some or all of our 2.0% senior convertible notes due 2017 after our stock price reaches $18.87 per share will dilute the ownership interests of our
existing stockholders. The senior convertible notes initially are convertible into approximately 13.25 million shares of our common stock. To the extent we issue any shares of our common stock upon conversion of the notes, the conversion of
some or all of the notes will dilute the ownership interests of existing stockholders, including holders who have received shares of our common stock upon prior conversion of the notes. Any sales in the public market of our common stock issuable
upon such conversion could adversely affect prevailing market prices of our common stock.

As of March 31, 2007 we had outstanding options to purchase
2,688,674 shares of our common stock at a weighted average exercise price of $8.32 per share (758,375 of which have not yet vested) issued to employees, directors and consultants pursuant to our 1995 Stock Option and Restricted Share Plan,
outstanding options to purchase 1,605,270 shares of our common stock at a weighted average exercise price of $14.67 per share (1,435,262 of which have not yet vested) issued to employees, directors and consultants pursuant to our 2005 Stock Option
and Restricted Share Plan and outstanding options to purchase 74,448 shares of our common stock at a weighted average exercise price of $1.42 per share (6,375 of which have not yet vested) to non-executive employees pursuant to our 2001 Equity
Incentive Plan. In order to attract and retain key personnel, we may issue additional securities, including stock options, restricted stock grants and shares of common stock, in connection with our employee benefit plans, or may lower the price of
existing stock options. Sale, or the availability for sale, of substantial amounts of common stock by our existing stockholders pursuant to an effective registration statement or under Rule 144, through the exercise of registration rights or the
issuance of shares of common stock upon the exercise of stock options or warrants, or the perception that such sales or issuances could occur, could adversely affect the prevailing market prices for our common stock.

The convertible note hedge and warrant transactions may affect the value of the senior convertible notes and our common stock.

In connection with the offering of the convertible senior notes, we have entered into convertible note hedge transactions with two counterparties (the
counterparties). These transactions are expected to generally reduce the potential equity dilution upon conversion of the senior convertible notes. We have also sold warrants to the counterparties. The warrants have a dilutive effect on
our earnings per share to the extent that the price of our common stock exceeds the strike price of the warrants.

In connection with establishing their
initial hedge of these transactions, the counterparties may have entered into various derivative transactions with respect to our common stock concurrently with, or shortly after, the pricing of the senior convertible notes. These activities could
have the effect of increasing or preventing a decline in the price of our common stock concurrently with or following the pricing of the senior convertible notes. In addition, the counterparties (and/or their affiliates) may modify their hedge
positions following the pricing of the senior convertible notes from time to time by entering into or unwinding various derivative transactions with respect to our common stock or by purchasing or selling our common stock in secondary market
transactions, which could adversely affect the value of our common stock or could have the effect of increasing or preventing a decline in the value of our common stock.



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The potential effect, if any, of any of these transactions and activities on the market price of our common stock will
depend in part on market conditions and cannot be ascertained at this time. Any of these activities could adversely affect the value of our common stock.

We do not make any representation or prediction as to the direction or magnitude of any potential effect that the transactions described above may have on the price of the senior convertible notes or the shares of our common stock. In
addition, we do not make any representation that the counterparties will engage in these transactions or that these transactions, once commenced, will not be discontinued without notice.

The fundamental change purchase feature of the senior convertible notes may delay or prevent an otherwise beneficial attempt to take over our company.

The terms of the senior convertible notes require us to purchase the senior convertible notes for cash in the event of a fundamental change. A takeover of our company
would trigger the requirement that we purchase the senior convertible notes. Alternatively, if certain transactions that constitute a fundamental change occur, under certain circumstances, we will increase the conversion rate by a number of
additional shares of our common stock to compensate holders for the lost option time value of the senior convertible notes as a result of such transaction. This increased conversion rate will apply only to holders who convert their senior
convertible notes in connection with any such transaction. The number of the additional shares of our common stock will be determined based on the date on which the transaction becomes effective and the price paid per share of our common stock. This
may have the effect of delaying or preventing a takeover of our company that would otherwise be beneficial to investors.

Our increased indebtedness as
a result of this offering may harm our financial condition and results of operations.

Our total consolidated long-term debt as of March 31, 2007
is $250.0 million and represents approximately 37.7% of our total capitalization.

Our level of indebtedness could have important consequences to you,
because:



| |  |  | a portion of our cash flows from operations will have to be dedicated to interest and may not be available for operations, working capital, capital expenditures,
expansion, acquisitions or general corporate or other purposes;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | it may impair our ability to obtain additional financing in the future;
| | - |  | -----------------------------------------------------------------------



| |  |  | it may limit our flexibility in planning for, or reacting to, changes in our business and industry; and
| | - |  | -------------------------------------------------------------------------------------------------------



| |  |  | it may make us more vulnerable to downturns in our business, our industry or the economy in general.
| | - |  | ----------------------------------------------------------------------------------------------------

Our operations may not generate sufficient cash to enable us to service our debt. If we fail to make a payment on the senior convertible notes, we could be in default on
the senior convertible notes, and this default could cause us to be in default on our other outstanding indebtedness. Conversely, a default on our other outstanding indebtedness may cause a default under the senior convertible notes.



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Core patent protection for Vancocin has expired, which could result in significant competition from generic products
and lead to a significant reduction in sales of Vancocin.

The last core patent protecting Vancocin expired in 1996. As a result, there is a potential
for significant competition from generic products that treat the same conditions addressed by Vancocin. Such competition could result in a significant reduction in sales of Vancocin. We believe that regulatory hurdles (notwithstanding the recent
actions taken by the FDAs Office of Generic Drugs, Center for Drug Evaluation and Research (OGD), which we describe in more detail below and which we are vigorously opposing), as well as product manufacturing trade secrets,
know-how and related non-patent intellectual property, may present barriers to market entry of generic competition. However, there can be no assurance that these barriers will actually delay or prevent generic competition. The effectiveness of these
non-patent-related barriers to competition will depend primarily upon:



| |  |  | the current or future regulatory approval requirements for any generic applicant.
| | - |  | ---------------------------------------------------------------------------------



| |  |  | the complexities of the manufacturing process for a competitive product;
| | - |  | ------------------------------------------------------------------------



| |  |  | the nature of the market which Vancocin serves and the position of Vancocin in the market from time to time;
| | - |  | ------------------------------------------------------------------------------------------------------------



| |  |  | the growth of the market which Vancocin serves; and
| | - |  | ---------------------------------------------------



| |  |  | our ability to protect Vancocin know-how as a trade secret.
| | - |  | -----------------------------------------------------------

We cannot assure you that generic competitors will not take advantage of the absence of patent protection for Vancocin to attempt to develop a competing product. We have become aware of information suggesting that other potential
competitors are attempting to develop a competing generic product. For example, Akorn, Inc. stated that during the fourth quarter of 2007 they expect to receive product approval and commence a marketing launch of a generic version of oral
Vancocin. We are not able to predict the time period in which a generic drug may enter the market, as this timing will be affected by a number of factors, including:



| |  |  | whether an in-vitro method of demonstrating bioequivalence is available to an applicant to gain marketing approval by the FDA in lieu of performing clinical
studies;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the nature of any clinical trials which are required, if any;
| | - |  | -------------------------------------------------------------



| |  |  | the timing of filing an Abbreviated New Drug Application, or ANDA, the amount of time required by the FDA to review the ANDA and whether a generic drug application
is afforded an accelerated review time by the FDA;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the specific formulation of drug for which approval is being sought; and
| | - |  | ------------------------------------------------------------------------



| |  |  | the time required to develop appropriate manufacturing procedures.
| | - |  | ------------------------------------------------------------------

On March 17, 2006, we learned that the OGD changed its approach regarding the conditions that must be met in order for a generic drug applicant to request a waiver of in-vivo bioequivalence testing for vancomycin
hydrochloride capsules. Specifically, we were informed that a generic applicant may be able to request such a waiver provided that dissolution testing demonstrates that the test product is rapidly dissolving at certain specified conditions. This
deviates from our understanding of OGDs historical practices which would require, for a poorly-absorbed, locally acting gastrointestinal drug (such as Vancocin) a demonstration of bioequivalence through clinical studies or a demonstration of
bioequivalence using an appropriately validated in-vivo methodology.

On March 17, 2006 we filed a Petition for Stay of Action with the FDA regarding
the requirements for waivers of in-vivo bioequivalence testing for Vancocin, and we amended that petition on March 30, 2006. In May 2006 and June 2006 we made additional filings in support of our opposition to any approach that does not require
rigorous scientific methods to demonstrate a rate and extent of drug release to the site of action consistent with good medicine and science. In the event the OGDs revised approach regarding the conditions that must be met in order for a
generic drug applicant to request a waiver of in-vitro bioequivalence testing for Vancocin remains in effect, the time period in which a generic competitor may enter the market would be reduced.

If a generic competitor were to formulate a competing product that was approved by the FDA and that gained market acceptance, it would have a material adverse effect on
our sales of Vancocin and on our business.



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|ITEM 6. | Exhibits
|------- | --------

List of Exhibits:



|       |  |                                                                                                                                                                                                                                            
|------ |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|4.1    |  | Form of Indenture dated march 19, 2007 between the Company and Wilmington Trust Company, as Trustee.(1)                                                                                                                                    
|       | 
|4.2    |  | First Supplemental Indenture, dated as of March 26, 2007, by and between the Company and Wilmington Trust Company, as Trustee.(2)                                                                                                          
|       | 
|10.1   |  | Confirmation of Convertible Bond Hedge Transaction, dated as of March 20, 2007, by and between ViroPharma Incorporated and Credit Suisse International and Credit Suisse, New York Branch, as
agent for Credit Suisse International.(2)    
|       | 
|10.2   |  | Confirmation of Convertible Bond Hedge Transaction, dated as of March 20, 2007, by and between ViroPharma Incorporated and Wells Fargo Bank, National Association.(2)                                                                      
|       | 
|10.3   |  | Confirmation of Issuer Warrant Transaction dated as of March 20, 2007, by and between ViroPharma Incorporated and Credit Suisse International and Credit Suisse, New York Branch, as agent for
Credit Suisse International.(2)             
|       | 
|10.4   |  | Confirmation of Issuer Warrant Transaction, dated as of March 20, 2007, by and between ViroPharma Incorporated and Wells Fargo Bank, National Association.(2)                                                                              
|       | 
|10.5   |  | Amendment to Confirmation of Issuer Warrant Transaction dated as of March 22, 2007, by and between ViroPharma Incorporated and Credit Suisse International and Credit Suisse, New York Branch, as
agent for Credit Suisse International.(2)
|       | 
|10.6   |  | Amendment to Confirmation of Issuer Warrant Transaction, dated as of March 22, 2007, by and between ViroPharma Incorporated and Wells Fargo Bank, National Association.(2)                                                                 
|       | 
|10.7 |  | Form of Change of Control Agreement between ViroPharma and certain of its employees.                                                                                                                                                       
|       | 
|31.1   |  | Certification by Chief Executive Officer pursuant to Rule 13a-14(a) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                                                                   
|       | 
|31.2   |  | Certification by Chief Financial Officer pursuant to Rule 13a-14(a) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.                                                                                   
|       | 
|32.1   |  | Certification Pursuant to 18 U.S.C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.                                                                                                                    

---

| | Compensation plans and arrangements for executives and others.
|-- | --------------------------------------------------------------

|(1) | Filed as an Exhibit to the Companys Registration Statement on Form S-3 (333-141411) filed with the Commission on March 19, 2007.
|--- | ---------------------------------------------------------------------------------------------------------------------------------

|(2) | Filed as an Exhibit to the Companys Current Report on Form 8-K filed with the Commission on March 26, 2007.
|--- | ------------------------------------------------------------------------------------------------------------



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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to
be signed on its behalf by the undersigned thereunto duly authorized.



|                  |  |                         |  |                                                                               
|----------------- |  | ----------------------- |  | ------------------------------------------------------------------------------
|                  |  | VIROPHARMA INCORPORATED
|                  |  |                        
|Date: May 1, 2007 |  | By:                     |  | /s/ Michel de Rosen                                                           
|                  |  |                         |  | Michel de Rosen                                                               
|                  |  |                         |  | President, Chief Executive Officer and Chairman of
the Board of Directors     
|                  |  |                         |  | (Principal Executive Officer)                                                 
|                  |  |                        
|                  |  | By:                     |  | /s/ Vincent J. Milano                                                         
|                  |  |                         |  | Vincent J. Milano                                                             
|                  |  |                         |  | Vice President, Chief Operating Officer, Chief Financial Officer and Treasurer
|                  |  |                         |  | (Principal Financial and Accounting Officer)                                  



32