*Note that agenda times are approximate. For further information, please contact the Designated Federal

Officer for this meeting, Jim Downing via telephone: (202) 564 - 2468 or email: downing.jim@epa.gov

**UNITED STATES ENVIRONMENTAL PROTECTION AGENCY**

**HUMAN STUDIES REVIEW BOARD (HSRB) PUBLIC TELECONFERENCE MEETING** 

**AGENDA Wednesday**  **, January 11**  **, 201 2**  **1 :**  **0 0**  **pm -**  **4 :00 pm (Eastern Time)**  ***** **HSRB MEETING FOR REVIEW AND APPROVAL OF THE**  **DRAFT OCTOBER 19**  **- 20**  **, 2011 HSRB**  **MEETING REPORT HSRB WEB SITE http://www.epa.gov/osa/hsrb/**  **Docket Telephone: (202) 566 1752**  **Docket Number: EP** **A –** **HQ –** **ORD –** **201 1**  **– 0953**  **Meeting l**  **ocation via telephone only**  **Dial in number 86 6**  **- 299**  **- 3188; conference code 202**  **564 7189**  **1 :**  **0 0**  **P M**  **Convene Meeting and Iden**  **tification of Board Members**

– Jim Downing

(Designated Federal Officer, EPA HSRB, OSA) **1 :**  **1 0**  **P M**  ***** **Meeting Administrative Procedures**

– Jim Downing, DFO **1 :**  **15 P**  **M Meeting Process**  **– Sean Philpot** **t** , Ph.D. (HSRB Chair) **1 :**  **2 0**  **P M**  **Public Comment s**  **1 :**  **3 0**  **P M**  **Board Discussion and**  **Decision on Final**  **Report –**  Sean Philpott , Ph.D. (HSRB

Chair) The Board’s response to EPA charge questions presented at the October 19 - 20 , 201 1 meeting. **A new scenario design and associated protocol from the Antimicrobial Exposure Assessment Task For**  **ce II (AEATF -**  **II), describing proposed research to monitor the dermal and inhalation exposure of workers while pouring liquid antimicrobial pesticide**  **products from both conventional and reduced -**  **splash containers.** Charge to the Board: If the AEATF liquid p our study proposal is revised as suggested in EPA’s review and if the research is performed as described:
 Is the research likel y to generate scientifically reliable data, useful for assessing the exposure of individuals who manually pour liquid antimicrob ial products?
 Is the research likel y to meet the applicable requirements of 40 CFR part 26, subparts K and L ? **A new scenario design and associated protocols from the Agricultural Handler Exposure Task Force (AHETF) describing proposed research to measure**  **dermal and inhalation***Note that agenda times are approximate. For further information, please contact the Designated Federal

Officer for this meeting, Jim Downing via telephone: (202) 564 - 2468 or email: downing.jim@epa.gov **exposure to workers who use closed system equipment to load liquid pesticide products from returnable and non**  **- returnable containers.**  Charge to the Board: If the AHETF closed system liquid loading study proposal is revised as sugge sted in EPA’s review and if the research is performed as described:
 Is the research likel y to generate scientifically reliable data, useful for assessing the exposure of workers using closed s ys tems to load liquid pesticide products from returnable or non - returnable containers?
 Is the research likel y to meet the applicable requirements of 40 CFR part 26, subparts K and L ? **A completed Carroll** **- Loy**  **e Biological Research, Inc. (CLBR) study (No Mas 003) to**  **evaluate the field repellent efficacy against mosquito es of a product containing 16% para**  **** **methane -**  **3,8 -**  **diol and 2% lemongrass oil.** Charge to the Board:
 Is the CLBR completed study N o M as 003 sufficiently sound, from a scientific perspective, to be used to estimate the duration of complete protection against mosquitoes provided b y the tested repellent?
 Does available information support a determination that the study No Mas 003 was conducted in substantial compliance with 40 CFR Part 26, subparts K and L ? **A published report by Moiemen et al**  **(2011) of an int entional exposure human study**  **measuring dermal absorption of silver from the use of nanosilver -**  **containing wound dressings to treat major burns.**  Charge to the Board:

 Is the Moiemen (2011) study scientificall y sound, providing reliable data?
 If so, can the Moiemen (2011) study be used to support the Agency's conclusion that the dermal absorption factor for silver from nanosilver on human skin is less than 0.1%?
 Is there adequate information to support a determination that the study was conducted in subs tantial compliance procedures at least as protective as those at subparts A - L of 40 CFR Part 26? **3 :**  **5 5**  **P M**  **Summary and Next Steps –**  Sean Philpott , Ph.D. (HSRB Chair) and Jim

Downing (DFO ) **4 :00**  **P M**  **Adjournment**