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                                 UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                               ----------------

                                  FORM 10-K/A
                                AMENDMENT NO. 1
(Mark One)
[X] Annual report pursuant to Section 13 or 15 (d) of the Securities Exchange
    Act of 1934
  For the fiscal year ended December 31, 1999 or

[_] Transition report pursuant to Section 13 or 15 (d) of the Securities
    Exchange Act of 1934

  (for the transition period from          to         )

                         Commission File No. 000-27855

                               ----------------

                           DATA CRITICAL CORPORATION
            (Exact name of registrant as specified in its charter)
<TABLE>
       <S>                                              <C>
                   Delaware                                   91-1901482
       (State or other jurisdiction of                     (I.R.S. Employer
        incorporation or organization)                  Identification Number)
</TABLE>

                     19820 North Creek Parkway, Suite 100,
                              Bothell, Washington
         (Address of principal executive offices, including zip code)

                                (425) 482-7000
              Registrant's telephone number, including area code:

                               ----------------

       Securities registered pursuant to Section 12(b) of the Act: None

Securities registered pursuant to Section 12 (g) of the Act: Common Stock, par
                            value $.0001 per share

                               ----------------

  Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
Registrant was required to file such reports), and (2) has been subject to
such filing requirements for the past 90 days. YES [X] NO [_]

  Indicate by check mark if disclosure of delinquent filers pursuant to Item
405 of Regulation S-K is not contained herein, and will not be contained, to
the best of the registrant's knowledge, in definitive proxy or information
statements incorporated by reference in Part III of this Form 10-K or any
amendment to this Form 10-K. [_]

  The aggregate market value of the voting stock held by non-affiliates of the
registrant, based upon the closing price of common stock on March 27, 2000, as
reported by Nasdaq, was approximately $148,670,844. Shares of voting stock
held by each officer and director and by each person who owns 5% or more of
the outstanding voting stock have been excluded in that such persons may be
deemed to be affiliates. This determination of affiliate status is not
necessarily a conclusive determination for other purposes.

  As of March 27, 2000, 10,691,118 shares of the registrant's common stock
were outstanding.

                      DOCUMENTS INCORPORATED BY REFERENCE

  Part III incorporates certain information by reference from the definitive
proxy statement for the Annual Meeting of Stockholders tentatively scheduled
for June 2, 2000.

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                                    PART IV

ITEM 14. EXHIBITS, FINANCIAL STATEMENT SCHEDULES, AND REPORTS ON FORM 8-K

  (a) The following documents are filed as a part of this report:

    (1) Financial Statements of the Registrant and Report of Arthur
    Andersen LLP

    (2) Financial Statement Schedules

        All schedules are omitted because they are not applicable or the
      required information is shown in the financial statements or notes
      thereto.

    (3) Exhibits (numbered in accordance with Item 601 of Regulation S-K)

  (b) Reports on Form 8-K.

  On December 22, 1999 we filed a report on Form 8-K pertaining to our
acquisition of substantially all the business, assets and rights of Physix,
Inc.

  (c) Exhibits

<TABLE>
<CAPTION>
  Number                                Description
  ------                                -----------
 <C>       <S>
  2.1(B)   Asset Purchase Agreement dated December 8, 1999 between Data
           Critical and Physix, Inc.


  2.2(B)   Registration Rights Agreement dated December 8, 1999 between Data
           Critical and Physix, Inc.


  3.1(A)   Amended and Restated Certificate of Incorporation of Data Critical.


  3.2(A)   Amended and Restated Bylaws of Data Critical.


  4.1(A)   Specimen Stock Certificate.


  4.2(A)   Amended and Restated Registration Rights Agreement dated February
           22, 1995, as amended.


  4.3(A)   Warrant Agreement dated April 13, 1995 between Data Critical and
           Spencer Trask Securities Incorporated with Form of Common Stock
           Purchase Warrant issued in connection with the Series B and Series C
           Preferred Stock financings.


  4.4(A)   Form of Common Stock Purchase Warrant issued in connection with the
           bridge loan financings.


  4.5(A)   Common Stock Purchase Warrant dated July 10, 1996 issued by Data
           Critical in favor of Nomadics, Inc.


  4.6(A)   Common Stock Purchase Warrant dated July 10, 1996 issued by Data
           Critical in favor of Colin Cumming.


 10.1(A)*  Termination and Patent License Agreement dated September 16, 1997
           between Data Critical and Hewlett-Packard Company.


 10.2(A)** Distribution and License Agreement dated January 23, 1997 between
           Data Critical and Marquette Medical Systems, Inc.


 10.3(A)** Addendum to Marquette Distribution and License Agreement dated
           September 14, 1998 between Data Critical and Marquette Medical
           Systems, Inc.


 10.4(A)   Employment Agreement dated June 14, 1999 between Data Critical and
           Michael E. Singer.


 10.5(C)   Amendment to Employment Agreement dated February 24, 2000 between
           Data Critical and Michael E. Singer.


 10.6(B)   Employment Agreement dated December 8, 1999 between Data Critical
           and Thomas Giannulli.


 10.7(A)   Facility Lease dated December 21, 1998 between S/I Northcreek II,
           L.L.C. and Data Critical.


 10.8(A)   Amendment dated March 30, 1999 to the Facility Lease dated December
           21, 1998 between S/I Northcreek II, L.L.C. and Data Critical.

</TABLE>


                                      60
<PAGE>

<TABLE>
<CAPTION>
   Number                               Description
   ------                               -----------
 <C>        <S>
 10.9(C)    Lease Contract between Greenway Plaza LTD and Data Critical, as
            successor in interest to Physix Inc. dated October 2, 1996.


 10.10(C)   First Amendment of Lease Contract between Crescent Real Estate
            Funding III, L.P. and Data Critical, as successor in interest to
            Physix Inc. dated April 23, 1998.


 10.11(A)   Form of Indemnification Agreement between Data Critical and each of
            its Officers and Directors.


 10.12(A)   1999 Stock Option Plan (adopted May 7, 1999).


 10.13(A)   1999 Directors' Stock Option Plan (adopted May 7, 1999).


 10.14(A)   1999 Employee Stock Purchase Plan (adopted May 7, 1999).


 10.15(A)   1994 Stock Option Plan (dated December 19, 1994).


 10.16(C)** Second Amendment to Distribution and License Agreement dated
            January 19, 2000 between Data Critical and GE Marquette Medical
            Systems, Inc.


 10.17      Employment Agreement dated November 11, 1999 between Data Critical
            and Robert A. May.


 21.1(C)    List of Subsidiaries.


 23.1(C)    Consent of Arthur Andersen LLP.


 24.1(C)    Power of Attorney (included in signature page to Registration
            Statement).


 27.1(C)    Financial Data Schedule
</TABLE>
--------
 *  Confidential treatment granted by order of the Commission.
**  Confidential treatment requested.
(A)  Incorporated herein by reference to the Company's Form S-1, as amended
     (File No. 333-78059) filed with the Commission on May 7, 1999.
(B)  Incorporated herein by reference to the Company's Form 8-K, as amended
     (File No. 000-27855) filed with the Commission on December 22, 1999.
(C)  Previously filed.

                                       61
<PAGE>

                                  SIGNATURES

  Pursuant to the requirements of Section 13 or 15(d) of the Securities
Exchange Act of 1934, as amended, the registrant has duly caused this
Amendment to be signed on its behalf by the undersigned, thereunto duly
authorized.

                                          Data Critical Corporation

                                                  /s/ Michael E. Singer
                                          By: _________________________________
                                                     Michael E. Singer
                                                  Vice President and Chief
                                                     Financial Officer

Dated: April 26, 2000

  Pursuant to the requirements of the Securities Exchange Act of 1934, as
amended, this Amendment has been signed below by the following persons in the
capacities indicated below on the 26th day of April, 2000.

<TABLE>
<CAPTION>
              Signature                          Title                   Date
              ---------                          -----                   ----


<S>                                    <C>                        <C>
                  *                    President, Chief Executive   April 26, 2000
______________________________________  Officer and Director
           Jeffrey S. Brown


       /s/ Michael E. Singer           Chief Financial Officer      April 26, 2000
 ______________________________________
          Michael E. Singer

                  *                    Director                     April 26, 2000
 ______________________________________
        David E. Albert, M.D.

                  *                    Director                     April 26, 2000
 ______________________________________
         George M. Middlemas

                  *                    Director                     April 26, 2000
 ______________________________________
           Richard Earnest

                                       Director
 ______________________________________
             Ronald Kase

                  *                    Director                     April 26, 2000
______________________________________
            David Swedlow
</TABLE>

   /s/ Michael E. Singer
*By: ____________________________
       Michael E. Singer
       Attorney-in-Fact

                                      62
<PAGE>

                                 EXHIBIT INDEX

<TABLE>
<CAPTION>
   Number                               Description
   ------                               -----------
 <C>        <S>
  2.1(B)    Asset Purchase Agreement dated December 8, 1999 between Data
            Critical and Physix, Inc.


  2.2(B)    Registration Rights Agreement dated December 8, 1999 between Data
            Critical and Physix, Inc.


  3.1(A)    Amended and Restated Certificate of Incorporation of Data Critical.


  3.2(A)    Amended and Restated Bylaws of Data Critical.


  4.1(A)    Specimen Stock Certificate.


  4.2(A)    Amended and Restated Registration Rights Agreement dated February
            22, 1995, as amended.


  4.3(A)    Warrant Agreement dated April 13, 1995 between Data Critical and
            Spencer Trask Securities Incorporated with Form of Common Stock
            Purchase Warrant issued in connection with the Series B and Series
            C Preferred Stock financings.


  4.4(A)    Form of Common Stock Purchase Warrant issued in connection with the
            bridge loan financings.


  4.5(A)    Common Stock Purchase Warrant dated July 10, 1996 issued by Data
            Critical in favor of Nomadics, Inc.


  4.6(A)    Common Stock Purchase Warrant dated July 10, 1996 issued by Data
            Critical in favor of Colin Cumming.


 10.1(A)*   Termination and Patent License Agreement dated September 16, 1997
            between Data Critical and Hewlett-Packard Company.


 10.2(A)**  Distribution and License Agreement dated January 23, 1997 between
            Data Critical and Marquette Medical Systems, Inc.


 10.3(A)**  Addendum to Marquette Distribution and License Agreement dated
            September 14, 1998 between Data Critical and Marquette Medical
            Systems, Inc.


 10.4(A)    Employment Agreement dated June 14, 1999 between Data Critical and
            Michael E. Singer.


 10.5(C)    Amendment to Employment Agreement dated February 24, 2000 between
            Data Critical and Michael E. Singer.


 10.6(B)    Employment Agreement dated December 8, 1999 between Data Critical
            and Thomas Giannulli.


 10.7(A)    Facility Lease dated December 21, 1998 between S/I Northcreek II,
            L.L.C. and Data Critical.


 10.8(A)    Amendment dated March 30, 1999 to the Facility Lease dated December
            21, 1998 between S/I Northcreek II, L.L.C. and Data Critical.


 10.9(C)    Lease Contract between Greenway Plaza LTD and Data Critical, as
            successor in interest to Physix Inc., dated October 2, 1996.


 10.10(C)   First Amendment of Lease Contract between Crescent Real Estate
            Funding III, L.P. and Data Critical, as successor in interest to
            Physix Inc., dated April 23, 1998.


 10.11(A)   Form of Indemnification Agreement between Data Critical and each of
            its Officers and Directors.


 10.12(A)   1999 Stock Option Plan (adopted May 7, 1999).


 10.13(A)   1999 Directors' Stock Option Plan (adopted May 7, 1999).


 10.14(A)   1999 Employee Stock Purchase Plan (adopted May 7, 1999).


 10.15(A)   1994 Stock Option Plan (dated December 19, 1994).


 10.16(C)** Second Amendment to Distribution and License Agreement dated
            January 19, 2000 between Data Critical and GE Marquette Medical
            Systems, Inc.
</TABLE>
<PAGE>

<TABLE>
<CAPTION>
 Number                                Description
 ------                                -----------
 <C>     <S>
 10.17   Employment Agreement dated November 11, 1999 between Data Critical and
         Robert A. May.


 21.1(C) List of Subsidiaries.


 23.1(C) Consent of Arthur Andersen LLP.


 24.1(C) Power of Attorney (included in signature page to Registration
         Statement).


 27.1(C) Financial Data Schedule
</TABLE>
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 *   Confidential treatment granted by order of the Commission.
**   Confidential treatment requested.
(A)  Incorporated herein by reference to the Company's Form S-1, as amended
     (File No. 333-78059) filed with the Commission on May 7, 1999.
(B)  Incorporated herein by reference to the Company's Form 8-K, as amended
     (File No. 000-27855) filed with the Commission on December 22, 1999.
(C)  Previously filed.