Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

PC Code: 122809

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY AND

 POLLUTION PREVENTION

MEMORANDUM

DATE: August 9, 2010

SUBJECT: Fluazifop-p- Butyl Acute and Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessment for the Section 3 Registration Action to add uses on 

Banana, Plantains, Citrus, Grapes, Potato and Sugar beet. 

PC Code: 122809 DP Barcode: D379452

Decision No.: 421332 Registration No.: 100-1070

Petition No.: 7F7289 Regulatory Action: Amended Section 3

Risk Assessment Type: Dietary Exposure Case No.: 2285

TXR No.: NA CAS No.: 79241-46-6

MRID No.: 40 CFR:180.411

REVIEWER:Seyed Tadayon, Chemist

Risk Assessment Branch V

Health Effects Division (7509P)

THROUGH: Thurston Morton, Chemist

David Soderberg, Chemist

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (7509P)

TO: Pete Savoia, Risk Assessor

Risk Assessment Branch V

Health Effects Division (7509P)
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

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Executive Summary

Acute and chronic dietary risk assessments for fluazifop-p-butyl were conducted using the Dietary

Exposure Evaluation Model DEEM-FCID, Version 2.03, which uses food consumption data from the 

USDA’s Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998. The 

analysis was performed to support newly proposed Section 3 registrations on banana, plantains, citrus, 

grapes, potato and sugar beet. 

An acute dietary (food and drinking water) exposure assessment was conducted for all established 

and proposed uses of fluazifop-p-butyl. Acute anticipated residues for all commodities were derived 

from tolerance level residues, and a ratio adjustment for additional metabolites of concern. Estimated and 

default processing factors along with percent crop treated (100%CT) were also used as available. 

Estimated drinking water concentrations (EDWCs) from the Environmental Fate and Effects Division 

(EFED) were also included. Surface drinking water concentrations were estimated using the 

PRZM/EXAMS computer model with the Index Reservoir and Percent Crop Area. The model predicts 

that the maximum concentration of total residues of fluazifop-p-butyl in surface water is not likely to 

exceed 33.4 ppb from the use of an aerial application to banana and plantains. Dietary risk estimates are 

provided for the only population subgroup with an acute dietary endpoint, females 13-49 years of age

(13% aPAD). No acute dietary end point attributable to a single dose was identified for general 

population including infants and children. This assessment concludes that for all supported registered 

commodities and new uses, the acute food plus water dietary risk estimates are below the Agency’s level 

of concern (<100 % aPAD).

A refined chronic dietary exposure analyses was also performed in order to determine the chronic 

exposure and risks that result from the registered uses and proposed uses of fluazifop-p-butyl. Mean 

residue level from crop field trials with a ratio adjustment for additional metabolites of concern, percent 

crop treated estimates, and experimentally determined processing factors were used in these assessments

(where available; otherwise default processing factors were used). A point estimate was used to assess 

the dietary exposure and risk resulting from fluazifop-p-butyl residues in water. Drinking water was 

represented by a single point estimate of average fluazifop-p-butyl residues. The estimated surface water

concentration of 6.6 ppb was based on the one in ten year annual mean from the grape application rate. 

Dietary risk estimates are provided for the U.S. population (total) and various population subgroups. This 

assessment also concludes that for all commodities, the chronic food plus water dietary risk estimates are 

below the Agency’s level of concern (<100 %cPAD) for the U.S. population (12% cPAD) and all 

population subgroups. The most highly exposed population subgroup in the chronic dietary exposure 

analysis is children 1-2 years of age (40% cPAD). 

Fluazifop-p-butyl is classified as a “not likely to be carcinogenic to humans;” therefore, no dietary

cancer assessment was performed.
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

PC Code: 122809

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I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and 

chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose 

which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to 

as the population adjusted dose (PAD). The PAD is equivalent to point of departure (POD, NOAEL, 

LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 

100% of the PAD. References which discuss the acute and chronic risk assessments in more detail are 

available on the EPA/pesticides web site: “Available Information on Assessing Exposure from 

Pesticides, A User’s Guide,” 6/21/2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf.

The most recent dietary assessment for fluazifop-p-butyl was conducted by S. Tadayon, D 3562009, 

9/16/ 2008.

II. Residue Information

Fluazifop-p-butyl is the resolved isomer (R enantiomer) of fluazifop-butyl [(R,S)-2-(4-((5-

(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)propanoic acid, butyl ester]. The fluazifop-butyl isomers are 

List B chemicals. Fluazifop-butyl (PC code 122805) has been canceled and only fluazifop-p-butyl is 

being supported for reregistration.

Fluazifop-p-butyl [(R)-2-(4-((5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)propanoic acid, butyl 

ester] is a selective herbicide registered for use for postemergence control of perennial and annual grass 

weeds. Fluazifop-p-butyl is currently registered for food/feed use on asparagus, carrot, coffee, cotton, 

endive (escarole), garlic, macadamia nut, onion (bulb), pecan, pepper, rhubarb, soybean, stone fruit, sweet 

potato, dry beans, peanuts, soybeans and yam (DP Barcode: 298939, S. Kinard, 6/22/04 and DP Barcode 

3562009, S.Tadayon, 9/16/2008 ).

Fluazifop-p-butyl Use

Fluazifop-p-butyl products are registered in the U.S. to Syngenta Crop Protection, Inc. Currently, 

the 0.086, 0.47, 1, 2, and 4 lb/gal emulsifiable concentrate (EC) formulations of fluazifop-p-butyl are 

registered for use on food/feed crops. The products are typically applied as postemergence foliar or soil 

applications using ground or aerial equipment; preplant, at-planting and/or postharvest applications (to 
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

PC Code: 122809

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the plant) are also registered for some crops.

The nature of the residue in plants and livestock is not adequately understood; additional plant 

metabolism studies with a root crop and a leafy vegetable, as well as ruminant and poultry metabolism 

studies must be submitted. In a meeting on March 3, 2004, the Metabolism Assessment Review 

Committee (MARC) recommended that for tolerance expression (both plants and animals), risk 

assessment of livestock commodities, and drinking water, the residues of concern are parent and 

fluazifop-acid (free and conjugated). However, the MARC also recommended that for risk assessment, 

the residues of concern are parent, fluazifop-acid (free and conjugated), 5-trifluoromethyl-2-pyridone, and 

2-(4-hydroxyphenoxy) propionic acid (free and conjugated) (DP Barcode: 298939, S. Kinard, 6/22/04).

Residue Data used for Acute and Chronic Assessments

For acute dietary exposure assessment, tolerance level residues with a ratio adjustment for 

additional metabolites of concern, 100 % crop treated (CT), and default processing factors were used. For 

chronic dietary exposure assessment, %CT estimates from BEAD (memo dated May 27, 2010 by A. 

Grube) and average value from field trials with a ratio adjustment were utilized. Default processing 

factor and measured processing factor (potato) were also used in chronic assessment. 

The analytical protocol can not detect the additional residues resulting from all metabolites. To 

account for all additional metabolites of concern for non-cancer risk identified by the MARC (parent, 

fluazifop-acid plus 5-trifluoromethyl-2-pyridone, and 2-(4-hydroxyphenoxy) propionic acid), data from 

the fluazifop carrot (MRID No. 00152494), celery (MRID No. 40693102), and soybean (MRID Nos. 

41994701-41994703) metabolism studies were used to derive residue adjustment factors by dividing 

residues of the pyridone plus the propionic acid by residues of parent and fluazifop-acid. Adjustment 

factors ranged from 0.12 xs to 0.9 xs. These adjustment factors were multiplied by the tolerance level or 

average field trial residues (parent plus fluazifop acid), to derive estimates of non-measured metabolite 

residues. The derived values and tolerance level residues were added together to reflect the total residue 

of concern (parent and fluazifop acid plus the pyridone plus the propionic acid). The ratios and estimates 

used in these assessments are listed in the tables 1 and 2.

Table 1. Metabolite Ratios

Residue Carrot roots* Celery stems Celery leaves Soybean

%TRR ppm %TRR ppm %TRR ppm %TRR ppm

fluazifop plus fluazifop acid 33.75 0.0885 39.6 0.032 62.7 0.401 28 3.1

5-trifluoromethyl-2-pyridone 1.0 0.003 2.8 0.003 9.6 0.061 – --

2-(4-hydroxyphenoxy) propionic acid 5.6 0.019 1.1 0.001 0.3 0.002 25.5 2.8

Ratio used in the assessment 0.25X 0.12X 0.16X 0.9X

 eg calculation (0.003 + 0.019)/0.0885=0.25X

 (0.25X)(Tolerance)+Tolerance=AR
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

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For the purpose of this petition only, the available soybean metabolism study and derived metabolite ratio

will support the new uses on banana, plantains, citrus, grapes, potato and sugar beet. The soybean ratio of 

0.9x used for the new uses. The resulting dietary assessment is very conservative. 

Field Trials

Adequate field trial data depicting fluazifop-p-butyl residues following applications made according to the 

maximum or proposed use patterns have been submitted for various crops. A summary of submitted field trial 

data are presented below:

Apricot

Apricot translated from peach and 100% CT assumed. Peach field trial data were used for apricot from 

MRID 92068039. There were 4 residue values. An average fluazifop-p-butyl residue point estimate of 0.015

ppm and an adjustment factor of 1.9 were used for the chronic analysis for all food forms.

Asparagus

BEAD estimates average % crop treated (CT) and maximum % CT of 2.5% and 5% CT for asparagus. Field 

trial data were used for asparagus from MRID 92068023. There were 8 residue values for asparagus. An 

average fluazifop-p-butyl residue point estimate of 0.57 ppm and an adjustment factor of 1.12 (0.64 ppm)

were used for the chronic analysis for all food forms. To account for % crop treated factor 2 was set to 0.025.

Cherry

BEAD estimates average % crop treated (CT) and maximum % CT of 1% and 2.5% CT for cherry. Field trial 

data were used for cherry from MRID 92068038. There were 5 residue values for cherry. An average 

fluazifop-p-butyl residue point estimate of 0.015 ppm and an adjustment factor of 1.9 (0.029 pm) were used 

for the chronic analysis for all food forms. To account for % crop treated factor 2 was set to 0.01.

Dry Beans

BEAD estimates average % crop treated (CT) and maximum % CT of 1% and 2.5% CT for dry beans. Field 

trial data were used for dry beans from MRID 47285501. There were 24 residue values for dry beans. An 

average fluazifop-p-butyl residue point estimate of 5.4 ppm and an adjustment factor of 1.9 (10.26 ppm) were 

used for the chronic analysis for all food forms. To account for % crop treated factor 2 was set to 0.01.

Endive

Field trial data were used for endive from MRID 92068027. There were 4 residue values for endive. An 

average fluazifop-p-butyl residue point estimate of 0.005 ppm and an adjustment factor of 1.16 were used for 

the chronic analysis for all food forms.

Macadamia Nut

Field trial data were used for macadamia nut from MRID 92068037. There were 8 residue values for 

macadamia nut. An average fluazifop-p-butyl residue point estimate of 0.05 ppm and an adjustment factor of 
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1.9 were used for the chronic analysis for all food forms.

Peach

BEAD estimates average % crop treated (CT) and maximum % CT of 2.5 and 10.0% CT for peach. Field 

trial data were used for peach from MRID 92068039. There were 4 residue values for peach. An average 

fluazifop-p-butyl residue point estimate of 0.015 ppm and an adjustment factor of 1.9 (0.029 ppm) were used 

for the chronic analysis for all food forms. To account for % crop treated factor 2 was set to 0.025.

Peanut

BEAD estimates average % crop treated (CT) and maximum % CT of 1% and 2.5% CT for peanut. Field 

trial data were used for peanut from MRID 47285503. There were 21 residue values for peanut. An average 

fluazifop-p-butyl residue point estimate of 0.40 ppm and an adjustment factor of 1.9 (0.76 ppm) were used for 

the chronic analysis for all food forms. To account for % crop treated factor 2 was set to 0.01.

Peppers

BEAD estimates average % crop treated (CT) and maximum % CT of 1% and 2.5% CT for peppers. Field 

trial data were used for pepper from MRID 92068031. There were 4 residue values for pepper. An average 

fluazifop-p-butyl residue point estimate of 0.06 ppm and an adjustment factor of 1.12 (0.67 ppm) were used 

for the chronic analysis for all food forms. To account for % crop treated factor 2 was set to 0.01.

Plum

Field trial data were used for plum from MRID 92068034. There were 8 residue values for plum. An average

fluazifop-p-butyl residue point estimate of 0.01 ppm and an adjustment factor of 1.9 (0.19 ppm) were used for 

the chronic analysis for all food forms. To account for % crop treated factor 2 was set to 0.01.

Rhubarb

Field trial data were used for rhubarb from MRID 92068032. There were 8 residue values for rhubarb. An 

average fluazifop-p-butyl residue point estimate of 0.19 ppm and an adjustment factor of 1.12 were used for 

the chronic analysis for all food forms.

Citrus

Field trial data were used for citrus from MRID 47874602. There were 17 residue values for citrus. An 

average fluazifop-p-butyl residue point estimate of 0.05 ppm and an adjustment factor of 1.9 were used for 

the chronic analysis for all food forms.

Carrot

BEAD estimates average % crop treated (CT) and maximum % CT of 10% and 20% CT for carrot. Field trial 

data were used for carrot from MRID 92068024. There were 12 residue values for carrot. An average 

fluazifop-p-butyl residue point estimate of 0.03 ppm and an adjustment factor of 1.125 (0.038) were used for 

the chronic analysis for all food forms. To account for % crop treated factor 2 was set to 0.10.

Onion

BEAD estimates average % crop treated (CT) and maximum % CT of 15% and 25% CT for onion. Field trial 

data were used for onion from MRID#s 92068028, 92068029. There were 19 residue values for onion. An 

average fluazifop-p-butyl residue point estimate of 0.03 and an adjustment factor of 1.125 (0.038) were used 

for the chronic analysis for all food forms. To account for % crop treated factor 2 was set to 0.15

Garlic 

BEAD estimates average % crop treated (CT) and maximum % CT of 5% and 10% CT for onion. Field trial 

data were translated from onion from MRID#s 92068028, 92068029. There were 19 residue values for onion. 

An average fluazifop-p-butyl residue point estimate of 0.03 and an adjustment factor of 1.125 (0.038) were 
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

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used for the chronic analysis for all food forms. To account for % crop treated factor 2 was set to 0.05.

Grapes

Field trial data were used for grape from MRID 47874604. There were 12 residue values for grape. An 

average fluazifop-p-butyl residue point estimate of 0.005 ppm and an adjustment factor of 1.9 were used for 

the chronic analysis for all food forms.

Potato

Field trial data were used for potato from MRID 47920402. There were 26 residue values for potato. An 

average fluazifop-p-butyl residue point estimate of 0.11 ppm and an adjustment factor of 1.25 were used for 

the chronic analysis for all food forms.

Soybeans

Field trial data were used for soybeans from MRID 92067046. There were 34 residue values for soybeans. 

An average fluazifop-p-butyl residue point estimate of 1.0 ppm and an adjustment factor of 1.9 (1.9) were 

used for the chronic analysis for all food forms. To account for % crop treated factor 2 was set to 0.025.

Sugar beet

Field trial data were used for sugar beet from MRID 47874603. There were 24 residue values soybeans. An 

average fluazifop-p-butyl residue point estimate of 0.08 ppm and an adjustment factor of 1.9 were used for 

the chronic analysis for all food forms.

Table 2. Residue Estimates Used in Dietary Analyses

RAC Food

Forms

%CT

(Acute)

%CT

(chronic

)

Processing

Factors

Tolerance Average Residue 

(Field Trials)

Ratio

Apricot all except dried 100 100 1 0.05 0.015 0.9 x

1

dried 6

Asparagus all 100 2.5 1 3.0 0.57 0.12x2

Banana (New Use) all 100 100 1 0.01 0.01 0.9 x1

Beef all except dried 100 100 1 0.05 0.05 NA

dried 100 1.92

Carrot all 100 10 1 2.0 0.03 0.25x4

1.5 juice

Cherry all 100 1.0 1 0.05 0.015 0.9x1

Chicken all 100 100 1 0.05 0.05 NA

Citrus (New Use) all 100 100 1 0.05 0.05 0.9x1

Coffee all 100 100 1 0.10 0.10 0.9x1

Cottonseed all 100 2.5 1 0.20 0.20 0.9x1

Dry Beans all 100 1.0 1 50 5.4 0.9x1

Egg all 100 100 1 0.05 0.05 NA

Endive all 100 100 1 6.0 0.05 0.16x3

Grapes (New Use) all 100 100 0.01 0.005 0.9x1

Goat all 100 100 1 0.05 0.05 NA

Garlic all except dried 100 5 1 0.50 0.03 0.25x4

dried

Horsemeat all 100 100 1 0.05 0.05 NA

Macadamia Nut all 100 100 1 0.10 0.05 0.9x
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Milk all 100 100 1 0.05 0.05 NA

Nectarine all 100 100 1 0.05 0.05 0.9x1

Onion (bulb) all except dried 100 15 1 0.50 0.03 0.25x4

dried 100 9

Peach all except dried 100 2.5 1 0.05 0.015 0.9x1

dried 100 7

Pecan all 100 100 1 0.05 0.05 0.9x1

Peanut all 100 1 1 1.5 0.38 0.9x1

Peanut oil 0.01

Peanut butter 1.89

Pepper (non-bell) all 100 1 1 1.0 0.6 0.12x2

Plantain (New Use) all 100 100 1 0.01 0.01 0.9x1

Plum all except dried and juice 100 100 1 0.05 0.01 0.9x1

dried 100 5

Prune, juice 100 1.4

Pork all 100 100 1 0.05 0.05 NA

Poultry all 100 100 1 0.05 0.05 NA

Potato (New Use) all 100 100 1.4 cooked 1 0.11 0.25x4

3.3 chips

6.4 dried

Rhubarb all 100 100 1 0.50 0.19 0.12x2

Sheep all 100 100 1 0.05 0.05 NA

Soybean all except oil 100 100 1 2.5 1.0 0.9x1

Soybean, oil oil 100 100 0.01 2.0 2.0 0.9x1

Spinach all 100 100 1 6 0.05 0.16x3

Sugar Beet (New 

Use)

Root 100 100 1 0.25 0.08 0.9x1

Top 100 1 1.50 008 0.9x1

Dried Pulp 100 1 1 0.08 0.9x1

Molasses 100 1 3.5 0.08 0.9x1

Sweet potato all 100 10 1 1.0 0.11 0.25x4

Turkey all 100 100 1 0.05 0.05 NA

Water all direct and indirect 

sources

100 100 1 0.0334 

(acute)

0.0066 

(chronic)

NA

Yam all 100 100 1 1.0 0.11 0.25x4

1 Soybean metabolism study.

2 Celery metabolism study (stalks).

3 Celery metabolism study (leaves).

4 Carrot metabolism study (roots).

III Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) in the following memorandum: “Revised Drinking 
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Water Assessment for the Section 3 Registration of Fluazifop-p-butyl For Use on bananas, plantains, 

citrus, grapes, and sugar beets pre-bloom and post-bloom (Wm. J. Shaughnessy, D371093, 05/25/2010)

and incorporated directly into this dietary assessment. Water residues were incorporated in the DEEMFCID into the food categories “water, direct, all sources” and “water, indirect, all sources.” 

Estimated exposure concentrations (EECs) in ground water were modeled using Tier I SCIGROW 

(version 2.3, dated July 29, 2003) and surface water EECs were modeled using Tier II PRZM (Pesticide 

Root Zone Model; vers. 3.12.2, May 12, 2005) and EXAMS (Exposure Analysis Modeling System; Vers. 

2.98.04.06). The results of this analysis are presented in Table 3. Estimated exposure concentrations 

represent exposure to fluazifop-acid, with assumptions that fluazifop-acid may be present in the R or S 

form or as a mixture of the enantiomers. 

The results of current assessment are higher than 2008 assessment (DP No. D347521, K. White, 

08/04/2008). For aerial applications the highest surface water EECs reported for peak, 1 in 10 year 

average, and the 30 year average as estimated by PRZM/EXAMS for all crop use scenarios were 33.4, 6.6 

ppb, and 4.4 ppb, respectively. For ground applications the highest EECs for peak, 1 in 10 year average, 

and the 30 year average were 32.1 ppb, 5.8 ppb, and 3.1 ppb, respectively. SCI-GROW estimated the 

concentration of fluazifop-acid in shallow ground water sources to be 1.56 ppb. The difference between 

the 2008 and current assessment results can be attributed to a proposed increase in the maximum number 

of allowable applications (i.e., 3 vs. 2), and differences in crop use scenarios used in the two assessments.

Table 3. Summary of the highest predicted surface water and ground water concentrations for the drinking water 

assessment on bananas, plantains, citrus, grapes, and sugar beets

Use

Estimated Drinking Water Concentration of Fluazifop-Acid (g/L)

Acute or Peak

1 in 10 year Average (Noncancer 

Chronic)

30 year Average (Cancer 

Chronic) 

Aerial Applications Surface Water

Bananas & Plantains 33.4 6.2 3.2

Citrus 28.5 5.4 3.7

Grapes 19.8 6.6 4.4

Sugar Beets

Ground Applications Surface Water

Bananas & Plantains 32.1 5.8 2.7

Citrus 27.3 5.1 2.8

Grapes 16.6 5.3 3.1

Sugar Beets 10.6 3.9 2.3

All Uses Ground Water

1.56 1.56 1.56

IV DEEM-FCID Program and Consumption Information

Fluazifop-p-butyl acute and chronic dietary exposure assessments were conducted using the Dietary Exposure 
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Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID, Version 2.03), which 

incorporates consumption data from USDA’s Continuing Surveys of Food Intakes by Individuals (CSFII), 1994-

1996 and 1998. The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals 

over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food 

commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, 

baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic 

exposure assessment, consumption data are averaged for the entire U.S. population and within population 

subgroups, but for acute exposure assessment are retained as individual consumption events. Based on analysis 

of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, 

HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. 

population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 

13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food-form (e.g., 

orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption 

estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for 

each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity

residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day

and as a percent of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an individual-byindividual basis. The reported consumption amounts of each food item can be multiplied by a residue point 

estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or 

“matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The 

resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who 

reported eating relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk 

are reported for all tiers of analysis. However, for tiers 1 and 2, any significant differences in user vs. per capita 

exposure and risk are specifically identified and noted in the risk assessment.

V. Toxicological Information

On May 6, 2004, the Health Effects Division (HED) Hazard Identification Assessment Review Committee 

(HIARC) reviewed the recommendations of the toxicology reviewer for Fluazifop-butyl and Fluazifop-p-butyl 

with regard to the acute and chronic Reference Doses (RfDs) and the toxicological endpoint selection for use as 

appropriate in occupational/residential exposure risk assessments. The potential for increased susceptibility of 

infants and children from exposure to Fluazifop-butyl and Fluazifop-p-butyl was also evaluated as required by

the Food Quality Protection Act (FQPA) of 1996 (TXR NO. 0052611; memo dated June 15, 2004 by D. 

Anderson). The conclusions drawn at this meeting are presented in Table 4 below.

Table 4. Summary of Toxicological Doses and Endpoints for Fluazifop-p-butyl for Use in Dietary Exposure Assessment
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Exposure

Scenario

Dose Used in Risk

Assessment, UF

Hazard and Exposure 

Based FQPA Safety 

Factor Study and Toxicological Effects

Acute Dietary

(General population including 

infants and children)

An appropriate endpoint attributable to a single dose was not identified in the available 

studies including the developmental toxicity studies.

Acute Dietary

(Females 13-49 years of age)

NOAEL = 50 

mg/kg/day

UF = 100

Acute RfD = 0.50 

mg/kg

FQPA SF = 1X

aPAD = acute RfD

 FQPA SF

= 0.50 mg/kg/day

Developmental Toxicity in rats.

LOAEL = 200 mg/kg/day based on 

diaphragmatic hernia.

Chronic Dietary

(All populations)

NOAEL= 0.74 

mg/kg/day

UF = 100

Chronic RfD = 

0.008 mg/kg/day

FQPA SF = 1X

cPAD = chronic RfD

 FQPA SF

= 0.0074 mg/kg/day

Two-Generation Reproduction in rats.

LOAEL = 5.8 mg/kg/day in males and 

7.1 in females based on decreased spleen, 

testes & epididymal weights in males and 

uterine & pituitary weights in females.

Cancer “Not likely to be carcinogenic to humans.”

VI.Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure of the U.S. population and 

various population subgroups. The results reported in Tables 5 and 6 are for the general U.S. Population, 

all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-

49, and adults 50+ years. 

Results of Acute Dietary Exposure Analysis

Dietary risk estimates are presented for the only population subgroup with an acute dietary endpoint, 

females 13-49 years of age (13 % aPAD at 95.0th percentile). No acute dietary end point attributable to a 

single dose was identified for general population including infants and children. This assessment 

concludes that for all supported registered commodities and new uses, the acute food plus water dietary

risk estimates are below the Agency’s level of concern (<100 % aPAD).This assessment is considered to 

be conservative. The results are listed below in Table 5.
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Table 5. Summary of Acute Dietary (Food + Drinking Water) Exposure and Risk for Fluazifop-p-butyl 

Population Subgroup

aPAD 

(mg/kg/day)

95th Percentile 99th Percentile 99.9th Percentile

Exposure 

(mg/kg/day

)

% 

aPAD

Exposure 

(mg/kg/day)

% 

aPAD

Exposure 

(mg/kg/day)

% 

aPAD

Female 13-49 years old 0.5 0.0641 13 0.1515 30 0.3673 74

Results of Chronic Dietary Exposure Analysis

This assessment concludes that for all commodities, the chronic food plus water dietary risk estimates 

are below the Agency’s level of concern (<100 %cPAD) for the U.S. population (12% cPAD) and all 

population subgroups. The most highly exposed population subgroup in the chronic dietary exposure 

analysis is children 1-2 years of age (40% cPAD). This assessment is still considered to be fairly

conservative since mean residue estimates were used. Results for all populations considered are listed 

below in Table 6.

Table6. Summary of Chronic Dietary (Food + Drinking Water) Exposure and Risk for Fluazifop-p-butyl.

Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) % cPAD

General U.S. Population

0.0074

0.0009 12

All Infants (< 1 year old) 0.0015 20

Children 1-2 years old 0.003 40

Children 3-5 years old 0.0022 30

Children 6-12 years old 0.0014 19

Youth 13-19 years old 0.0008 11

Adults 20-49 years old 0.007 8.9

Adults 50+ years old 0.0006 8.7

Females 13-49 years old 0.0006 8.6

VII. Characterization of Inputs/Outputs

Anticipated residues for all registered and proposed food commodities were based on field trial data

and percent crop treated. Although field trial data provide more refined exposure estimates than 
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tolerances, the results may still be considered somewhat conservative, since field trials are conducted 

under maximum use conditions (maximum allowed application rate and number of applications, 

minimum PHI, etc.). 

VIII. Conclusions

Acute and chronic dietary exposure analyses (including food and water) were performed in order to 

determine the exposure and risks resulting from the registered uses and new proposed uses of fluazifop-pbutyl. Tolerance level values with a ratio adjustment for additional metabolites of concern, default 

processing factors, and refined point estimates for residues in water were used in these assessments.

Percent CT refinements were included for the acute and chronic dietary exposure analysis. This 

assessment concludes that for all supported registered commodities and new proposed uses, the acute 

dietary risk estimates are below the Agency’s level of concern (<100 %aPAD) for females 13-49 years of 

age (<13 % aPAD) at the 95th exposure percentile. Chronic dietary risk estimates are provided for the 

U.S. population (total) and various population subgroups. The chronic assessment concludes that for all 

supported commodities and proposed uses, the chronic dietary risk estimates are below the Agency’s 

level of concern (<100 %cPAD) for the U.S. population (12% cPAD) and all population subgroups. The 

most highly exposed population subgroup in the chronic dietary exposure analysis is children 1-2 years of 

age (40% cPAD).

VIII. List of Attachments

· Acute Food plus Water Residue Input file.

· Chronic Food plus Water Residue Input file.

· Acute Results file.

· Chronic Results file.

· Percent Crop Treated Memo from BEAD
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Attachment: Acute Food plus Water Residue Input File

Filename: C:\Documents and Settings\stadayon\My Documents\Work in 

Progress\122809a.R98

Chemical: Fluazifop p butyl

RfD(Chronic): 0 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 07-27-2010/13:23:34/8 Program ver. 2.03

--------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

12000120 12 Apricot 0.095000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

12000121 12 Apricot-babyfood 0.095000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

12000130 12 Apricot, dried 0.095000 6.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

12000140 12 Apricot, juice 0.095000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

12000141 12 Apricot, juice-babyfood 0.095000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

95000190 O Asparagus 3.360000 1.000 0.010 Ratio 

 Full comment: Ratio from celery metabolism
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95000230 O Banana 0.019000 1.000 1.000 

95000231 O Banana-babyfood 0.019000 1.000 1.000 

95000240 O Banana, dried 0.019000 1.000 1.000 

95000241 O Banana, dried-babyfood 0.019000 1.000 1.000 

06030300 6C Bean, black, seed 95.000000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06030320 6C Bean, broad, seed 95.000000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06030340 6C Bean, cowpea, seed 95.000000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06030350 6C Bean, great northern, seed 95.000000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06030360 6C Bean, kidney, seed 95.000000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06030380 6C Bean, lima, seed 95.000000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06030390 6C Bean, mung, seed 95.000000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06030400 6C Bean, navy, seed 95.000000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06030410 6C Bean, pink, seed 95.000000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06030420 6C Bean, pinto, seed 95.000000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

21000440 M Beef, meat 0.050000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 

21000450 M Beef, meat, dried 0.050000 1.920 1.000 

21000460 M Beef, meat byproducts 0.050000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.050000 1.000 1.000 

21000470 M Beef, fat 0.050000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.050000 1.000 1.000 

21000480 M Beef, kidney 0.050000 1.000 1.000 

21000490 M Beef, liver 0.050000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.050000 1.000 1.000 

01010500 1AB Beet, garden, roots 0.475000 1.000 1.000 

01010501 1AB Beet, garden, roots-babyfood 0.475000 1.000 1.000 

02000510 2 Beet, garden, tops 2.850000 1.000 1.000 

01010520 1A Beet, sugar 0.475000 1.000 1.000 

01010521 1A Beet, sugar-babyfood 0.475000 1.000 1.000 

01010530 1A Beet, sugar, molasses 6.650000 1.000 1.000 

01010531 1A Beet, sugar, molasses-babyfood 6.650000 1.000 1.000 

01010780 1AB Carrot 2.500000 1.000 0.100 Ratio 

 Full comment: Ratio from carrot metabolism

01010781 1AB Carrot-babyfood 2.500000 1.000 0.100 Ratio 

 Full comment: Ratio from carrot metabolism

01010790 1AB Carrot, juice 2.500000 1.000 0.100 Ratio 

 Full comment: Ratio from carrot metabolism

12000900 12 Cherry 0.095000 1.000 1.000 

12000901 12 Cherry-babyfood 0.095000 1.000 1.000 

12000910 12 Cherry, juice 0.095000 1.500 1.000 

12000911 12 Cherry, juice-babyfood 0.095000 1.500 1.000 

40000930 P Chicken, meat 0.050000 1.000 1.000 

40000931 P Chicken, meat-babyfood 0.050000 1.000 1.000 

40000940 P Chicken, liver 0.050000 1.000 1.000 

40000950 P Chicken, meat byproducts 0.050000 1.000 1.000 

40000951 P Chicken, meat byproducts-babyfoo 0.050000 1.000 1.000 

40000960 P Chicken, fat 0.050000 1.000 1.000 
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40000961 P Chicken, fat-babyfood 0.050000 1.000 1.000 

40000970 P Chicken, skin 0.050000 1.000 1.000 

40000971 P Chicken, skin-babyfood 0.050000 1.000 1.000 

06030980 6C Chickpea, seed 95.000000 1.000 1.000 

06030981 6C Chickpea, seed-babyfood 95.000000 1.000 1.000 

06030990 6C Chickpea, flour 95.000000 1.000 1.000 

10001060 10 Citrus citron 0.100000 1.000 1.000 

10001070 10 Citrus hybrids 0.100000 1.000 1.000 

10001080 10 Citrus, oil 0.100000 1.000 1.000 

95001150 O Coffee, roasted bean 0.190000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

95001160 O Coffee, instant 0.190000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

95001280 O Cottonseed, oil 0.380000 1.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

95001281 O Cottonseed, oil-babyfood 0.380000 1.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

70001450 P Egg, whole 0.050000 1.000 1.000 

70001451 P Egg, whole-babyfood 0.050000 1.000 1.000 

70001460 P Egg, white 0.050000 1.000 1.000 

70001461 P Egg, white (solids)-babyfood 0.050000 1.000 1.000 

70001470 P Egg, yolk 0.050000 1.000 1.000 

70001471 P Egg, yolk-babyfood 0.050000 1.000 1.000 

04011500 4A Endive 6.960000 1.000 1.000 

03001640 3 Garlic 0.625000 1.000 1.000 

03001650 3 Garlic, dried 0.625000 9.000 1.000 

03001651 3 Garlic, dried-babyfood 0.625000 9.000 1.000 

23001690 M Goat, meat 0.050000 1.000 1.000 

23001700 M Goat, meat byproducts 0.050000 1.000 1.000 

23001710 M Goat, fat 0.050000 1.000 1.000 

23001720 M Goat, kidney 0.050000 1.000 1.000 

23001730 M Goat, liver 0.050000 1.000 1.000 

13021740 13B Gooseberry 0.019000 1.000 1.000 

95001750 O Grape 0.019000 1.000 1.000 

95001760 O Grape, juice 0.019000 1.000 1.000 

95001761 O Grape, juice-babyfood 0.019000 1.000 1.000 

95001770 O Grape, leaves 0.019000 1.000 1.000 

95001780 O Grape, raisin 0.019000 1.000 1.000 

95001790 O Grape, wine and sherry 0.019000 1.000 1.000 

10001800 10 Grapefruit 0.100000 1.000 1.000 

10001810 10 Grapefruit, juice 0.100000 1.000 1.000 

06031820 6C Guar, seed 95.000000 1.000 1.000 

06031821 6C Guar, seed-babyfood 95.000000 1.000 1.000 

10001970 10 Kumquat 0.100000 1.000 1.000 

10001990 10 Lemon 0.100000 1.000 1.000 

10002000 10 Lemon, juice 0.100000 1.000 1.000 

10002001 10 Lemon, juice-babyfood 0.100000 1.000 1.000 

10002010 10 Lemon, peel 0.100000 1.000 1.000 

06032030 6C Lentil, seed 95.000000 1.000 1.000 

10002060 10 Lime 0.100000 1.000 1.000 

10002070 10 Lime, juice 0.100000 1.000 1.000 

10002071 10 Lime, juice-babyfood 0.100000 1.000 1.000 

14002130 14 Macadamia nut 0.190000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

27002220 D Milk, fat 0.050000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.050000 1.000 1.000 

27012230 D Milk, nonfat solids 0.050000 1.000 1.000 
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

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27012231 D Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 

27022240 D Milk, water 0.050000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.050000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000 

12002300 12 Nectarine 0.095000 1.000 1.000 

03002370 3 Onion, dry bulb 0.625000 1.000 0.150 Ratio 

 Full comment: Ratio from carrot metabolism

03002371 3 Onion, dry bulb-babyfood 0.625000 1.000 0.150 Ratio 

 Full comment: Ratio from carrot metabolism

03002380 3 Onion, dry bulb, dried 0.625000 9.000 0.150 Ratio 

 Full comment: Ratio from carrot metabolism

03002381 3 Onion, dry bulb, dried-babyfood 0.625000 9.000 0.150 Ratio 

 Full comment: Ratio from carrot metabolism

10002400 10 Orange 0.100000 1.000 1.000 

10002410 10 Orange, juice 0.100000 1.000 1.000 

10002411 10 Orange, juice-babyfood 0.100000 1.000 1.000 

10002420 10 Orange, peel 0.100000 1.000 1.000 

12002600 12 Peach 0.095000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

12002601 12 Peach-babyfood 0.095000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

12002610 12 Peach, dried 0.095000 7.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

12002611 12 Peach, dried-babyfood 0.095000 7.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

12002620 12 Peach, juice 0.095000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

12002621 12 Peach, juice-babyfood 0.095000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

95002630 O Peanut 2.850000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

95002640 O Peanut, butter 2.850000 1.890 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

95002650 O Peanut, oil 2.850000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

14002690 14 Pecan 0.095000 1.000 1.000 

08002720 8 Pepper, nonbell 1.120000 1.000 1.000 Ratio 

 Full comment: Ratio from celery metabolism

08002721 8 Pepper, nonbell-babyfood 1.120000 1.000 1.000 Ratio 

 Full comment: Ratio from celery metabolism

08002730 8 Pepper, nonbell, dried 1.120000 1.000 1.000 Ratio 

 Full comment: Ratio from celery metabolism

12002850 12 Plum 0.095000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

12002851 12 Plum-babyfood 0.095000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

12002860 12 Plum, prune, fresh 0.095000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

12002861 12 Plum, prune, fresh-babyfood 0.095000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

12002870 12 Plum, prune, dried 0.095000 5.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

12002871 12 Plum, prune, dried-babyfood 0.095000 5.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

12002880 12 Plum, prune, juice 0.095000 1.400 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

12002881 12 Plum, prune, juice-babyfood 0.095000 1.400 1.000 Ratio 
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

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 Full comment: Ratio from soybean metabolism

25002900 M Pork, meat 0.050000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 

25002910 M Pork, skin 0.050000 1.000 1.000 

25002920 M Pork, meat byproducts 0.050000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.050000 1.000 1.000 

25002930 M Pork, fat 0.050000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.050000 1.000 1.000 

25002940 M Pork, kidney 0.050000 1.000 1.000 

25002950 M Pork, liver 0.050000 1.000 1.000 

01032960 1C Potato, chips 1.250000 3.300 1.000 

01032970 1C Potato, dry (granules/ flakes) 1.250000 6.400 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 1.250000 6.400 1.000 

01032980 1C Potato, flour 1.250000 6.400 1.000 

01032981 1C Potato, flour-babyfood 1.250000 6.400 1.000 

01032990 1C Potato, tuber, w/peel 1.250000 1.400 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 1.250000 1.400 1.000 

01033000 1C Potato, tuber, w/o peel 1.250000 1.400 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 1.250000 1.400 1.000 

60003010 P Poultry, other, meat 0.050000 1.000 1.000 

60003020 P Poultry, other, liver 0.050000 1.000 1.000 

60003030 P Poultry, other, meat byproducts 0.050000 1.000 1.000 

60003040 P Poultry, other, fat 0.050000 1.000 1.000 

60003050 P Poultry, other, skin 0.050000 1.000 1.000 

10003070 10 Pummelo 0.050000 1.000 1.000 

04023220 4B Rhubarb 0.560000 1.000 1.000 Ratio 

 Full comment: Ratio from celery metabolism

26003390 M Sheep, meat 0.050000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 

26003410 M Sheep, fat 0.050000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.050000 1.000 1.000 

26003420 M Sheep, kidney 0.050000 1.000 1.000 

26003430 M Sheep, liver 0.050000 1.000 1.000 

06003470 6 Soybean, seed 4.750000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06003480 6 Soybean, flour 4.750000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06003481 6 Soybean, flour-babyfood 4.750000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06003490 6 Soybean, soy milk 4.750000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06003491 6 Soybean, soy milk-babyfood or in 4.750000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06003500 6 Soybean, oil 4.750000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

06003501 6 Soybean, oil-babyfood 4.750000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

04013550 4A Spinach 6.960000 1.000 1.000 Ratio 

 Full comment: Ratio from celery metabolism

04013551 4A Spinach-babyfood 6.960000 1.000 1.000 Ratio 

 Full comment: Ratio from celery metabolism

01033660 1CD Sweet potato 1.250000 1.000 1.000 Ratio 

 Full comment: Ratio from carrot metabolism

01033661 1CD Sweet potato-babyfood 1.250000 1.000 1.000 Ratio 

 Full comment: Ratio from carrot metabolism

10003690 10 Tangerine 0.050000 1.000 1.000 
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

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10003700 10 Tangerine, juice 0.050000 1.000 1.000 

50003820 P Turkey, meat 0.050000 1.000 1.000 

50003821 P Turkey, meat-babyfood 0.050000 1.000 1.000 

50003830 P Turkey, liver 0.050000 1.000 1.000 

50003831 P Turkey, liver-babyfood 0.050000 1.000 1.000 

50003840 P Turkey, meat byproducts 0.050000 1.000 1.000 

50003841 P Turkey, meat byproducts-babyfood 0.050000 1.000 1.000 

50003850 P Turkey, fat 0.050000 1.000 1.000 

50003851 P Turkey, fat-babyfood 0.050000 1.000 1.000 

50003860 P Turkey, skin 0.050000 1.000 1.000 

50003861 P Turkey, skin-babyfood 0.050000 1.000 1.000 

86010000 O Water, direct, all sources 0.033400 1.000 1.000 

86020000 O Water, indirect, all sources 0.033400 1.000 1.000 

01034060 1CD Yam, true 1.250000 1.000 1.000 

01034070 1CD Yam bean 1.250000 1.000 1.000 

Attachment: Chronic Food plus Water Residue Input File

Filename: C:\Documents and Settings\stadayon\My Documents\Work in Progress\122809c 

2010 .R98

Chemical: Fluazifop p butyl

RfD(Chronic): 0 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day

Date created/last modified: 07-28-2010/07:57:28/8 Program ver. 2.03

--------------------------------------------------------------------------------

Note: No residue distributions have been assigned to Commodities/FoodForms below

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ -------

95000190 O Asparagus 0.640000 1.000 0.025 Ratio 

 Full comment: Ratio from celery metabolism

95001150 O Coffee, roasted bean 0.190000 1.000 1.900 Ratio 

 Full comment: Ratio from soybean metabolism

95001160 O Coffee, instant 0.190000 1.000 1.900 Ratio 

 Full comment: Ratio from soybean metabolism

95001280 O Cottonseed, oil 0.380000 1.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

95001281 O Cottonseed, oil-babyfood 0.380000 1.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

95001750 O Grape 0.005000 1.000 1.900 

95001760 O Grape, juice 0.005000 1.000 1.900 

95001761 O Grape, juice-babyfood 0.005000 1.000 1.900 
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

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95001770 O Grape, leaves 0.005000 1.000 1.900 

95001780 O Grape, raisin 0.005000 1.000 1.900 

95001790 O Grape, wine and sherry 0.005000 1.000 1.900 

95002630 O Peanut 0.760000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

95002640 O Peanut, butter 0.760000 1.890 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

95002650 O Peanut, oil 0.760000 0.010 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

86010000 O Water, direct, all sources 0.006600 1.000 1.000 

86020000 O Water, indirect, all sources 0.006600 1.000 1.000 

21000440 M Beef, meat 0.050000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 

21000450 M Beef, meat, dried 0.050000 1.920 1.000 

21000460 M Beef, meat byproducts 0.050000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.050000 1.000 1.000 

21000470 M Beef, fat 0.050000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.050000 1.000 1.000 

21000480 M Beef, kidney 0.050000 1.000 1.000 

21000490 M Beef, liver 0.050000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.050000 1.000 1.000 

23001690 M Goat, meat 0.050000 1.000 1.000 

23001700 M Goat, meat byproducts 0.050000 1.000 1.000 

23001710 M Goat, fat 0.050000 1.000 1.000 

23001720 M Goat, kidney 0.050000 1.000 1.000 

23001730 M Goat, liver 0.050000 1.000 1.000 

25002900 M Pork, meat 0.050000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 

25002910 M Pork, skin 0.050000 1.000 1.000 

25002920 M Pork, meat byproducts 0.050000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.050000 1.000 1.000 

25002930 M Pork, fat 0.050000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.050000 1.000 1.000 

25002940 M Pork, kidney 0.050000 1.000 1.000 

25002950 M Pork, liver 0.050000 1.000 1.000 

26003390 M Sheep, meat 0.050000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 

26003410 M Sheep, fat 0.050000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.050000 1.000 1.000 

26003420 M Sheep, kidney 0.050000 1.000 1.000 

26003430 M Sheep, liver 0.050000 1.000 1.000 

40000930 P Chicken, meat 0.050000 1.000 1.000 

40000931 P Chicken, meat-babyfood 0.050000 1.000 1.000 

40000940 P Chicken, liver 0.050000 1.000 1.000 

40000950 P Chicken, meat byproducts 0.050000 1.000 1.000 

40000951 P Chicken, meat byproducts-babyfoo 0.050000 1.000 1.000 

40000960 P Chicken, fat 0.050000 1.000 1.000 

40000961 P Chicken, fat-babyfood 0.050000 1.000 1.000 

40000970 P Chicken, skin 0.050000 1.000 1.000 

40000971 P Chicken, skin-babyfood 0.050000 1.000 1.000 

70001450 P Egg, whole 0.050000 1.000 1.000 

70001451 P Egg, whole-babyfood 0.050000 1.000 1.000 

70001460 P Egg, white 0.050000 1.000 1.000 

70001461 P Egg, white (solids)-babyfood 0.050000 1.000 1.000 

70001470 P Egg, yolk 0.050000 1.000 1.000 

70001471 P Egg, yolk-babyfood 0.050000 1.000 1.000 
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60003010 P Poultry, other, meat 0.050000 1.000 1.000 

60003020 P Poultry, other, liver 0.050000 1.000 1.000 

60003030 P Poultry, other, meat byproducts 0.050000 1.000 1.000 

60003040 P Poultry, other, fat 0.050000 1.000 1.000 

60003050 P Poultry, other, skin 0.050000 1.000 1.000 

50003820 P Turkey, meat 0.050000 1.000 1.000 

50003821 P Turkey, meat-babyfood 0.050000 1.000 1.000 

50003830 P Turkey, liver 0.050000 1.000 1.000 

50003831 P Turkey, liver-babyfood 0.050000 1.000 1.000 

50003840 P Turkey, meat byproducts 0.050000 1.000 1.000 

50003841 P Turkey, meat byproducts-babyfood 0.050000 1.000 1.000 

50003850 P Turkey, fat 0.050000 1.000 1.000 

50003851 P Turkey, fat-babyfood 0.050000 1.000 1.000 

50003860 P Turkey, skin 0.050000 1.000 1.000 

50003861 P Turkey, skin-babyfood 0.050000 1.000 1.000 

27002220 D Milk, fat 0.050000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.050000 1.000 1.000 

27012230 D Milk, nonfat solids 0.050000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 

27022240 D Milk, water 0.050000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.050000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000 

01010500 1AB Beet, garden, roots 0.080000 1.000 1.900 

01010501 1AB Beet, garden, roots-babyfood 0.080000 1.000 1.900 

01010520 1A Beet, sugar 0.080000 1.000 1.900 

01010521 1A Beet, sugar-babyfood 0.080000 1.000 1.900 

01010530 1A Beet, sugar, molasses 0.080000 1.000 1.900 

01010531 1A Beet, sugar, molasses-babyfood 0.080000 1.000 1.900 

01010780 1AB Carrot 0.038000 1.000 0.100 Ratio 

 Full comment: Ratio from carrot metabolism

01010781 1AB Carrot-babyfood 0.038000 1.000 0.100 Ratio 

 Full comment: Ratio from carrot metabolism

01010790 1AB Carrot, juice 0.038000 1.500 0.100 Ratio 

 Full comment: Ratio from carrot metabolism

01032960 1C Potato, chips 0.110000 3.300 1.250 

01032970 1C Potato, dry (granules/ flakes) 0.110000 6.400 1.250 

01032971 1C Potato, dry (granules/ flakes)-b 0.110000 6.400 1.250 

01032980 1C Potato, flour 0.110000 6.400 1.250 

01032981 1C Potato, flour-babyfood 0.110000 6.400 1.250 

01032990 1C Potato, tuber, w/peel 0.110000 1.400 1.250 

01032991 1C Potato, tuber, w/peel-babyfood 0.110000 1.400 1.250 

01033000 1C Potato, tuber, w/o peel

01033001 1C Potato, tuber, w/o peel-babyfood 0.110000 1.400 1.250 

01033660 1CD Sweet potato 0.110000 1.000 1.250 Ratio 

 Full comment: Ratio from carrot metabolism

01033661 1CD Sweet potato-babyfood 0.110000 1.000 1.250 Ratio 

 Full comment: Ratio from carrot metabolism

01034060 1CD Yam, true 0.110000 1.000 1.250 

01034070 1CD Yam bean 0.110000 1.000 1.250 

02000510 2 Beet, garden, tops 1.300000 1.000 1.900 

03001640 3 Garlic 0.038000 1.000 0.050 

03001650 3 Garlic, dried 0.038000 9.000 0.050 

03001651 3 Garlic, dried-babyfood 0.038000 9.000 0.050 

03002370 3 Onion, dry bulb 0.038000 1.000 0.150 Ratio 

 Full comment: Ratio from carrot metabolism

03002371 3 Onion, dry bulb-babyfood 0.038000 1.000 0.150 Ratio 

 Full comment: Ratio from carrot metabolism
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

PC Code: 122809

Page 22 of 27

03002380 3 Onion, dry bulb, dried 0.038000 9.000 0.150 Ratio 

 Full comment: Ratio from carrot metabolism

03002381 3 Onion, dry bulb, dried-babyfood 0.038000 9.000 0.150 Ratio 

 Full comment: Ratio from carrot metabolism

04011500 4A Endive 0.050000 1.000 1.160 

04023220 4B Rhubarb 0.190000 1.000 1.120 Ratio 

 Full comment: Ratio from celery metabolism

04013550 4A Spinach 0.050000 1.000 1.160 Ratio 

 Full comment: Ratio from celery metabolism

04013551 4A Spinach-babyfood 0.050000 1.000 1.160 Ratio 

 Full comment: Ratio from celery metabolism

06030300 6C Bean, black, seed 10.260000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

06030320 6C Bean, broad, seed 10.260000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

06030340 6C Bean, cowpea, seed 10.260000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

06030350 6C Bean, great northern, seed 10.260000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

06030360 6C Bean, kidney, seed 10.260000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

06030380 6C Bean, lima, seed 10.260000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

06030390 6C Bean, mung, seed 10.260000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

06030400 6C Bean, navy, seed 10.260000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

06030410 6C Bean, pink, seed 10.260000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

06030420 6C Bean, pinto, seed 10.260000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

06030980 6C Chickpea, seed 10.260000 1.000 0.010 

06030981 6C Chickpea, seed-babyfood 10.260000 1.000 0.010 

06030990 6C Chickpea, flour 10.260000 1.000 0.010 

06031820 6C Guar, seed 10.260000 1.000 0.010 

06031821 6C Guar, seed-babyfood 10.260000 1.000 0.010 

06032030 6C Lentil, seed 10.260000 1.000 0.010 

06003470 6 Soybean, seed 1.900000 1.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

06003480 6 Soybean, flour 1.900000 1.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

06003481 6 Soybean, flour-babyfood 1.900000 1.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

06003490 6 Soybean, soy milk 1.900000 1.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

06003491 6 Soybean, soy milk-babyfood or in 1.900000 1.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

06003500 6 Soybean, oil 1.900000 0.010 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

06003501 6 Soybean, oil-babyfood 1.900000 0.010 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

08002720 8 Pepper, nonbell 0.670000 1.000 0.010 Ratio 

 Full comment: Ratio from celery metabolism

08002721 8 Pepper, nonbell-babyfood 0.670000 1.000 0.010 Ratio 

 Full comment: Ratio from celery metabolism

08002730 8 Pepper, nonbell, dried 0.670000 1.000 0.010 Ratio 

 Full comment: Ratio from celery metabolism
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

PC Code: 122809

Page 23 of 27

10001060 10 Citrus citron 0.005000 1.000 1.900 

10001070 10 Citrus hybrids 0.005000 1.000 1.900 

10001080 10 Citrus, oil 0.005000 1.000 1.900 

10001800 10 Grapefruit 0.005000 1.000 1.900 

10001810 10 Grapefruit, juice 0.005000 1.000 1.900 

10001970 10 Kumquat 0.005000 1.000 1.900 

10001990 10 Lemon 0.005000 1.000 1.900 

10002000 10 Lemon, juice 0.005000 1.000 1.900 

10002001 10 Lemon, juice-babyfood 0.005000 1.000 1.900 

10002010 10 Lemon, peel 0.005000 1.000 1.900 

10002060 10 Lime 0.005000 1.000 1.900 

10002070 10 Lime, juice 0.005000 1.000 1.900 

10002071 10 Lime, juice-babyfood 0.005000 1.000 1.900 

10002400 10 Orange 0.005000 1.000 1.900 

10002410 10 Orange, juice 0.005000 1.000 1.900 

10002411 10 Orange, juice-babyfood 0.005000 1.000 1.900 

10002420 10 Orange, peel 0.005000 1.000 1.900 

10003070 10 Pummelo 0.005000 1.000 1.900 

10003690 10 Tangerine 0.005000 1.000 1.900 

10003700 10 Tangerine, juice 0.005000 1.000 1.900 

12000120 12 Apricot 0.015000 1.000 1.900 Ratio 

 Full comment: Ratio from soybean metabolism

12000121 12 Apricot-babyfood 0.015000 1.000 1.900 Ratio 

 Full comment: Ratio from soybean metabolism

12000130 12 Apricot, dried 0.015000 6.000 1.900 Ratio 

 Full comment: Ratio from soybean metabolism

12000140 12 Apricot, juice 0.015000 1.000 1.900 Ratio 

 Full comment: Ratio from soybean metabolism

12000141 12 Apricot, juice-babyfood 0.015000 1.000 1.900 Ratio 

 Full comment: Ratio from soybean metabolism

12000900 12 Cherry 0.029000 1.000 0.010 

12000901 12 Cherry-babyfood 0.029000 1.000 0.010 

12000910 12 Cherry, juice 0.029000 1.500 0.010 

12000911 12 Cherry, juice-babyfood 0.029000 1.500 0.010 

12002300 12 Nectarine 0.015000 1.000 1.900 

12002600 12 Peach 0.029000 1.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

12002601 12 Peach-babyfood 0.029000 1.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

12002610 12 Peach, dried 0.029000 7.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

12002611 12 Peach, dried-babyfood 0.029000 7.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

12002620 12 Peach, juice 0.029000 1.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

12002621 12 Peach, juice-babyfood 0.029000 1.000 0.025 Ratio 

 Full comment: Ratio from soybean metabolism

12002850 12 Plum 0.019000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

12002851 12 Plum-babyfood 0.019000 1.000 1.000 Ratio 

 Full comment: Ratio from soybean metabolism

12002860 12 Plum, prune, fresh 0.019000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

12002861 12 Plum, prune, fresh-babyfood 0.019000 1.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

12002870 12 Plum, prune, dried 0.019000 5.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

PC Code: 122809

Page 24 of 27

12002871 12 Plum, prune, dried-babyfood 0.019000 5.000 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

12002880 12 Plum, prune, juice 0.019000 1.400 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

12002881 12 Plum, prune, juice-babyfood 0.019000 1.400 0.010 Ratio 

 Full comment: Ratio from soybean metabolism

14002130 14 Macadamia nut 0.050000 1.000 1.900 Ratio 

 Full comment: Ratio from soybean metabolism

14002690 14 Pecan 0.050000 1.000 1.900 

Attachment: Acute Food plus Water Results File

U.S. Environmental Protection Agency Ver. 2.02

DEEM-FCID ACUTE Analysis for FLUAZIFOP P BUTYL (1994-98 data)

Residue file: 122809a.R98 Adjustment factor #2 NOT used.

Analysis Date: 07-27-2010/14:01:47 Residue file dated: 07-27-2010/13:23:34/8

Daily totals for food and foodform consumption used.

Run Comment: ""

===============================================================================

Summary calculations (per capita):

 95th Percentile 99th Percentile 99.9th Percentile

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Females 13-49 yrs:

 0.064111 12.82 0.151503 30.30 0.367295 73.46 

Attachment: Chronic Food plus Water Results File

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for FLUAZIFOP P BUTYL (1994-98 data)

Residue file name: C:\Documents and Settings\stadayon\My Documents\Work in Progress\122809c 2010 

.R98

Adjustment factor #2 used.

Analysis Date 07-28-2010/07:59:35 Residue file dated: 07-28-2010/07:57:28/8

Reference dose (RfD, Chronic) = .0074 mg/kg bw/day

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

PC Code: 122809

Page 25 of 27

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.000904 12.2%

U.S. Population (spring season) 0.000903 12.2%

U.S. Population (summer season) 0.000885 12.0%

U.S. Population (autumn season) 0.000925 12.5%

U.S. Population (winter season) 0.000902 12.2%

Northeast region 0.000874 11.8%

Midwest region 0.000963 13.0%

Southern region 0.000853 11.5%

Western region 0.000949 12.8%

Hispanics 0.001045 14.1%

Non-hispanic whites 0.000887 12.0%

Non-hispanic blacks 0.000856 11.6%

Non-hisp/non-white/non-black 0.000980 13.2%

All infants (< 1 year) 0.001482 20.0%

Nursing infants 0.000521 7.0%

Non-nursing infants 0.001846 25.0%

Children 1-6 yrs 0.002423 32.7%

Children 7-12 yrs 0.001322 17.9%

Females 13-19 (not preg or nursing) 0.000685 9.3%

Females 20+ (not preg or nursing) 0.000624 8.4%

Females 13-50 yrs 0.000708 9.6%

Females 13+ (preg/not nursing) 0.000785 10.6%

Females 13+ (nursing) 0.000879 11.9%

Males 13-19 yrs 0.000883 11.9%

Males 20+ yrs 0.000680 9.2%

Seniors 55+ 0.000644 8.7%

Children 1-2 yrs 0.002988 40.4%

Children 3-5 yrs 0.002231 30.1%

Children 6-12 yrs 0.001406 19.0%

Youth 13-19 yrs 0.000787 10.6%

Adults 20-49 yrs 0.000659 8.9%

Adults 50+ yrs 0.000643 8.7%

Females 13-49 yrs 0.000639 8.6%

-------------------------------------------------------------------------------

-----------------------------------------------------------------------------
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

PC Code: 122809

Page 26 of 27

Attachment Percent Crop Treated Memo from BEAD
Fluazifop-p-butyl Dietary Exposure Assessment DP Bar code: D379452

PC Code: 122809

Page 27 of 27