Fluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 1 of 27

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION 

### MEMORANDUM DATE: August 9 , 20 1 0 SUBJECT: Fluazifop - p - Butyl Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessment for the Section 3 Registration Action to ad d u se s on B anana, Plantains, Citrus, Grapes, Potato and Sugar beet . PC Code: 122809 DP B arcode: D 379452 Decision No.: 421332 Registration No. : 100 - 1070 Petition No.: 7F7289 Regulatory Action: Amended Section 3 Risk Assessment Type: Dietary Exposure Case No.: 2285 T XR No.: NA CAS No.: 79241 - 46 - 6 MRID No.: 40 CFR: 180.411

REVIEWER: Seyed Tadayon , Chemist

Risk Assessment Branch V Health Effects Division (7509 P ) THROUGH: Thurston Morton , Chemist

David Soderberg , Chemist Dietary Exposure Science Advisory Council (DESAC) Health Effects Division (7509 P ) TO: Pete Savoia , Risk Assessor

R isk Assessment Branch V Health Effects Division (7509 P )Fluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 2 of 27 Executive Summary A cute and chronic dietary risk assessments for fluazifop - p - butyl were conducted using the Dietary Exposure Evaluation Model DEEM - FCID  , Version 2.03, which uses food consumption data from the USDA’s Continuing Survey s of Food Intakes by Individuals (CSFI I) from 1994 - 1996 and 1998. The analy sis was performed to support newly p ro posed S ection 3 registrations on banana, plantains , citrus, grapes , potato and sugar beet . An a cute dietary

(food and drinking water) exposure assessment was conducted for all established and proposed uses of fluazifop - p - butyl . Acute anticipated residues for all commodities were derived from t olerance level residues , and a ratio adjustment for addi tional metabolites of concern . Estimated and default processing factors along with percent crop treated ( 100 %CT) were also used as available. Estimated drinking water concentrations (EDWCs) from the Environmental Fate and Effects Division (EFED) were als o included. Surface drinking water concentrations were estimated using the PRZM/EXAMS computer model with the Index Reservoir and Percent Crop Area. The model predicts that the maximum concentration of total residues of fluazifop - p - butyl in surface water is not likely to exceed 33.4 ppb from the use of an aerial application to banana and plantains. Dietary risk estimates are provided for the only

population subgroup with an acute dietary endpoint, females 13 - 49 years of age ( 1 3 % aPAD) . No acute dietary end p o i nt attributable to a single dose was identified for general population including infants and children. This assessment concludes that for all supported registered commodities and new uses , the acute food plus water dietary risk estimates are below the Agency ’s level of concern (<100 % aPAD) . A refined c hronic dietary exposure analy ses was also performed in order to determine the chronic exposure and risks that result from the registered uses and proposed uses of fluazifop - p - butyl. Mean residue lev el from crop field trials with a ratio adjustment for additional metabolites of concern, percent crop treated estimates, and experimentally determined processing factors were used in these assessments (where available; otherwise default processing factors were used) . A point estimate was used to assess the dietary

exposure and risk resulting from fluazifop - p - butyl residues in water. Drinking water was represented by

a single point estimate of average fluazifop - p - butyl residues. The estimated surface water concentration of 6.6 ppb was based on the one in ten year annual mean from the grape application rate. Dietary risk estimates are provided for the U.S. population (total) and various population subgroups. This assessment also concludes that for all comm odities, the chronic food plus water dietary risk estimates are below the Agency ’s level of concern (<100 %cPAD) for the U.S. population ( 12 % cPAD) and all population subgroups. The most highly exposed population subgroup in the chronic dietary exposure analy sis is children 1 - 2 years of age ( 40 % cPAD ). Fluazifop - p - butyl is classified as a “not likely to be carcinogenic to humans;” therefore, no dietary cancer assessment was performed.Fluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 3 of 27 I. Introduction Dietary risk assessment incorporates both exp osure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is re ferred to as the population adjusted dose (PAD). The PAD is equivalent to point of departure (POD, NOAEL , LOAEL, e.g.) divided by

the required uncertainty

or safety factors. For acute and non - cancer chronic exposures, HED is concerned when estimated die tary risk exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 6/21/2000, web link: http://www.epa.gov/fedrgstr/EPA - PEST/2000/July /Day- 12/6061.pdf

. The m ost recent dietary

assessment for fluazifop - p - butyl was conducted by S. Tadayon, D 3562009, 9/16 / 2008. II. Residue Information Fluazifop - p - butyl is the resolved isomer (R enantiomer) of fluazifop - butyl [( R,S ) - 2 - (4 - ((5 - (trifluoromethyl) - 2 - py

ridinyl)oxy

)phenoxy )propanoic acid, butyl ester]. The fluazifop - butyl isomers are Li st B chemicals. Fluazifop - butyl (PC code 122805) has been canceled and only fluazifop - p - butyl is being s upported for reregistration. Fluazifop - p - butyl [(

R ) - 2 - (4 - ((5 - (trifluoromethyl) - 2 - py ridinyl)oxy

)phenoxy )propanoic acid, butyl ester] is a selective herbicide registered for use for postemergence control of perennial and annual grass weeds. Fluazifop - p - butyl is currently registered for food/feed use on asparagus, carrot, coffee, cotton, endive (escarole), garlic, macadamia nut, onion (bulb), pecan, pepper, rhubarb, soy bean, stone fruit, sweet potato, dry

beans, peanuts, soy

beans and yam (DP Barcode: 298939 , S. Kinard, 6/22/04 and DP Barcode 3562009, S.Tadayon, 9/16/2008 ). Fluazifop - p - butyl Use Fluazifop - p - butyl products are registered in the U.S. to Sy ngenta Crop Protection, Inc. Currently , the 0.086, 0.47, 1, 2, and 4 lb/gal emulsifiable concentrate (E C) formulations of fluazifop - p - butyl are registered for use on food/feed crops. The products are ty pically applied as postemergence foliar or soil applications using ground or aerial equipment; preplant, at - planting and/or postharvest applications (toFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 4 of 27 the plant) are also registered for some crops. The nature of the residue in plants and livestock is not adequately understood; additional plant metabolism studies with a root crop and a leafy vegetable, as well as ruminant and poultry metabolism studies mus t be submitted. In a meeting on March 3, 2004, the Metabolism Assessment Review Committee (MARC) recommended that for tolerance expression (both plants and animals), risk assessment of livestock commodities, and drinking water, the residues of concern are parent and fluazifop - acid (free and conjugated) . However, the MARC also recommended that for risk assessment, the residues of concern are parent, fluazifop - acid (free and conjugated), 5 - trifluoromethyl - 2 - py ridone, and 2 - (4 - hydroxy

phenoxy ) propionic acid ( free and conjugated) (DP Barcode: 298939, S. Kinard, 6/22/04). Residue Data used for Acute and Chronic Assessments For acute dietary

exposure assessment, tolerance level residues with a ratio adjustment for additional metabolites of concern, 100 % crop treated (CT), and default processing factors were used . F or chronic dietary

exposure assessment, %CT estimates from BEAD (memo dated May 27 , 20 10 by

A. Grube) and average value from field trials with a ratio adjustment were utilized. Default processing fa ctor and measured processing factor (potato ) were also used in chronic assessment. The analy tical protocol can not detect the additional residues resulting from all metabolites. To account for all additional metabolites of concern for non - cancer risk i dentified by the MARC (parent, fluazifop - acid plus 5 - trifluoromethyl - 2 - py ridone, and 2 - (4 - hydroxy phenoxy ) propionic acid), data from the fluazifop carrot (MRID No. 00152494), celery (MRID No. 40693102), and soy bean (MRID Nos. 41994701 - 41994703) metabolism studies were used to derive residue adjustment factors by dividing residues of the py

ridone plus the propionic acid by residues of parent and fluazifop - acid. Adjustment factors ranged from 0.12 xs to 0.9 xs . These adjustment factors were multiplied by th e tolerance level or average field trial residues (parent plus fluazifop acid), to derive estimates of non - measured metabolite residues. The derived values and tolerance level residues were added together to reflect the total residue of concern (parent an d fluazifop acid plus the py ridone plus the propionic acid). The ratios and estimates used in these assessments are listed in the tables 1 and 2. Table 1. Metabolite Ratios Residue Carrot roots* Celery stems Celery leaves Soybean %TRR ppm %TRR ppm %T RR ppm %TRR ppm fluazifop plus fluazifop acid 33.75 0.0885 39.6 0.032 62.7 0.401 28 3.1 5 - trifluoromethyl - 2 - pyridone 1.0 0.003 2.8 0.003 9.6 0.061

– -- 2 - (4 - hydroxyphenoxy) propionic acid 5.6 0.019 1.1 0.001 0.3 0.002 25.5 2.8 Ratio used in the assessm ent 0.25X 0.12X 0.16X 0.9X  eg calculation (0.003 + 0.019)/0.0885=0.25X  (0.25X)(Tolerance)+Tolerance=ARFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 5 of 27 For the purpose of this petition only , the available soy bean metabolism study and derived metabolite ratio will support the new uses on banana, plantai ns, citrus, grapes, potato and sugar beet . The soy bean ratio of 0.9x used for the new uses. The resulting dietary assessment is very

conservative.

Field Trials Adequate field trial data depicting fluazifop - p - butyl residues following applicati ons made according to the maximum or proposed use patterns have been submitted for various crops. A summary o f submitted field trial data are presented below: Apricot Apricot translated from peach and 100 % CT assumed. Peach f ield trial data were used fo r apricot from MRI D 92068039 . There were 4 residue values . An average fluazifop - p - buty l residue point estimate of 0.0 15 ppm an d an adjustment factor of 1.9 w ere used for the chronic analy sis for all food forms. Asparagus BEAD estimates average % crop tre ated (CT) and maximum % CT of 2.5% and 5% CT for asparagus. F ield trial data were used for asparagus from MRID 92068023. There were 8 residue values for asparagus. An average fluazifop - p - butyl residue point estimate of 0. 57 ppm and an adjustment factor o f 1.12 (0.64 ppm) were used for the chronic analy sis for all food forms. To account for % crop treated factor 2 was set to 0.025. Cherry BEAD estimates average % crop treated (CT) and maximum % CT of 1% and 2.5% CT for c herry . F ield trial data were used f

or cherry from MRID 92068038. There were 5 residue values for cherry . An average fluazifop - p - butyl residue point estimate of 0. 0 15 ppm and an adjustment factor of 1.9 (0.029 pm) were used for the chronic analy sis for all food forms. To account for % crop treated factor 2 was set to 0.01. Dry Beans BEAD estimates average % crop treated (CT) and maximum % CT of 1% and 2.5% CT for dry b eans. F ield trial data were used for dry beans from MRI D 47285501. There were 24 residue values for dry beans. An average f luazifop - p - butyl residue point estimate of 5.4 ppm and an adjustment factor of 1.9 (10.26 ppm) were used for the chronic analy sis for all food forms. To account for % crop treated factor 2 was set to 0.01. Endive Field trial data were used for endive from MRID 92068027. T here were 4 residue values for endive. An average fluazifop - p - butyl residue point estimate of 0.005 ppm and an adjustment factor of 1.16 were used for the chronic analy sis for all food forms. Macadamia Nut Field trial data were used for m acadamia nut from MRID 920680 3 7. T here were 8 residue values for macadamia nut . An average fluazifop - p - butyl residue point estimate of 0.0 5 ppm and an adjustment factor ofFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 6 of 27 1.9 were used for the chronic analy sis for all food forms . Peach BEAD estimates av erage % crop treated (CT) and maximum % CT of 2.5 and 10.0% CT for peach. Field trial data were used for peach from MRID 92068039. There were 4 residue values for peach . An average fluazifop - p - butyl residue point estimate of 0. 015 ppm and an adjustment f actor of 1.9 (0.029 ppm) were used for the chronic analy sis for all food forms. To account for % crop treated factor 2 was set to 0.025. Peanut BEAD estimates average % crop treated (CT) and maximum % CT of 1% and 2.5% CT for peanut. Field trial data were used for peanut from MRID 47285503. There were 21 residue values for peanut. An average fluazifop - p - butyl residue point estimate of 0. 40 ppm and an adjustment factor of 1.9 (0.76 ppm) were used for the chronic analy sis for all food forms. To account for % crop treated factor 2 was set to 0.01 . Peppers BEAD estimates average % crop treated (CT) and maximum % CT of 1% and 2.5% CT for peppers. Field trial data were used for pepper from MRID 92068031 . There were 4 residue values for pepper . An average fluaz ifop - p - butyl residue point estimate of 0. 06 ppm and an adjustment factor of 1.12 (0.67 ppm) were used for the chronic analy sis for all food forms. To account for % crop treated factor 2 was set to 0.01. Plum Field trial data were used for p lum from MRID 9 2068034. T here were 8 residue values for plum. An average fluazifop - p - butyl residue point estimate of 0.01 ppm and an adjustment factor of 1.9 (0.19 ppm) were used for the chronic analy sis for all food forms. To account for % crop treated factor 2 was se t to 0.01 . R h ubarb Field trial data were used for r hubarb from MRID 9206803 2 . There were 8 residue values for r hubarb . An average fluazifop - p - butyl residue point estimate of 0. 19 ppm and an adjustment factor of 1.12 were used for the chronic analy sis for all food forms . Citrus Field trial data were used for citrus from MRID 47874602 . T here were 17 residue values for citrus. An average fluazifop - p - butyl residue point estimate of 0. 05 ppm and an adjustment factor of 1.9 were used for the chronic analy sis for all food forms . Carrot BEAD estimates average % crop treated (CT) and maximum % CT of 10% and 20% CT for carrot. F ield trial data were used for carrot from MRID 92068024. There were 12 residue values for carrot. An average fluazifop - p - butyl residue p oint estimate of 0.03 ppm and an adjustment factor of 1.125 (0.038) were used for the chronic analy sis for all food forms. To account for % crop treated factor 2 was set to 0.10. Onion BEAD estimates average % crop treated (CT) and maximum % CT of 15% and 25% CT for onion. F ield trial data were used for onion from MRID#s 92068028, 92068029. There were 19 residue values for onion. An average fluazifop - p - butyl residue point estimate of 0.03 and an adjustment factor of 1.125 (0.038) were used for the chronic analy sis for all food forms . To account for % crop treated factor 2 was set to 0.15 Garlic BEAD estimates average % crop treated (CT) and maximum % CT of 5% and 10% CT for onion. F ield trial data were translated from onion from MRID#s 92068028, 92068029 . There were 19 residue values for onion. An average fluazifop - p - butyl residue point estimate of 0.03 and an adjustment factor of 1.125 (0.038) wereFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 7 of 27 used for the chronic analy sis for all food forms. To account for % crop treated factor 2 was set to 0.05. Grapes Field trial data were used for grape from MRID 47874604 . T here were 12 residue values for grape. An average fluazifop - p - butyl residue point estimate of 0.0 05 ppm and an adjustment factor of 1.9 were used for the chronic analy sis for all food forms . Potato Field trial data were used for potato from MRI D 47920402 . There were 2 6 residue values for potato. An average fluazifop - p - butyl residue point estimate of 0. 1 1 ppm and an adjustment factor of 1.25 were used for the chronic analy sis for all food f orms . Soybeans Field trial data were used for soy beans from MRID 9206 7 0 46 . There were 34 residue values for soy beans . An average fluazifop - p - butyl residue point estimate of 1. 0 ppm and an adjustment factor of 1.9 (1.9) were used for the chronic analy sis for all food forms . To account for % crop treated factor 2 was set to 0.025. Sugar beet Field trial data were used for sugar beet from MRID 47874603 . T here were 24 residue values soy beans. An average fluazifop - p - butyl residue point estimate of 0.08 ppm and an adjustment factor of 1.9 were used for the chronic analy sis for all food forms. Table 2. Residue Estim ates Used in Dietary Analyses RAC Food Forms %CT

(Acute) %CT

(chronic ) Processing

Factors Tolerance Average Residue ( Field Trials ) Ratio Apric ot all except dried 100 100 1 0.05 0.015 0.9 x 1 dried 6 Asparagus a ll 100 2.5 1 3.0 0.57 0.12x 2 Banana (New Use) all 100 100 1 0.01 0.01 0.9 x 1 Beef all except dried 100 100 1 0.05 0.05 N A dried 100 1.92 Carrot all 100 10 1 2.0 0.03 0.25x 4 1.5 juice Cherry all 100 1.0 1 0.05 0.015 0.9x 1 Chicken all 100 100 1 0.05 0.05 NA Citrus (New Use) all 100 100 1 0.05 0.05 0.9x 1 Coffee all 100 100 1 0.10 0.10 0.9x 1 Cottonseed all 100 2.5 1 0.20 0.20 0.9x 1 Dry Beans all 100 1.0 1 50 5.4 0.9x 1 Egg all 100 100 1 0.05 0.05 NA Endive all 100 100 1 6.0 0.05 0.16x 3 Grapes (New Use) all 100 100 0.01 0.005 0.9x 1 Goat all 100 100 1 0.05 0.05 NA Garlic all except dried 100 5 1 0.50 0.03 0.25x 4 dried Horsemeat all 100 100 1 0 . 05 0.05 NA Macadamia Nut all 100 100 1 0.10 0.05 0.9xFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 8 of 27 Milk all 100 100 1 0.05 0.05 NA Nectarine all 100 100 1 0.05 0.05 0.9x 1 Onion (bulb) all except dried 100 1 5 1 0.50 0.03 0.25x 4 dried 100 9 Peach all except dried 100 2.5 1 0.05 0.015 0.9x 1 dried 100 7 Pecan all 100 100 1 0.05 0.05 0.9x 1 Peanut all 100 1 1 1.5 0.38 0.9x 1 Peanut oil 0.01 Peanut butter 1.89 Pepper (non - bell) all 100 1 1 1.0 0.6 0.12x 2 Plantain (New Use) all 100 100 1 0.01 0.01 0.9x 1 Plum all except dried and ju ice 100 100 1 0.05 0.01 0.9x 1 dried 100 5 Prune, juice 100 1.4 Pork all 100 100 1 0.05 0.05 NA Poultry all 100 100 1 0.05 0.05 NA Potato (New Use) all 100 100 1.4 cooked 1 0.11 0.25x 4 3.3 chips 6.4 dried Rhubarb all 100 100 1 0.50 0.19 0.12x 2 Sheep all 100 100 1 0.05 0.05 NA Soybean all except oil 100 100 1 2.5 1.0 0.9x 1 Soybean, oil oil 100 100 0.01 2.0 2.0 0.9x 1 Spinach a ll 100 100 1 6 0.05 0.16x 3 Sugar Beet (New Use) Root 100 100 1 0.25 0.08 0.9x 1 Top 100 1 1. 5 0 0 08 0.9x 1 Dried Pulp 100 1 1 0.08 0.9x 1 Molasses 100 1 3. 5 0.08 0.9x 1 Sweet potato all 100 10 1 1.0 0.11 0.25x 4 Turkey all 100 100 1 0.05 0.05 NA Water all direct and indirect sources 100 100 1 0.0334 (acute) 0.0066 (chronic) NA

Yam all 100 100 1 1.0 0.11 0.25x 4 

### 1 Soy

bean metabolism study . 2 Celery

metabolism study

(stalks). 3 Celery

metabolism study

(leaves). 4 Carrot metabolism study (roots). III Drinking Water Data The drinking water residues used in the dietary risk assessment were p rovided by the Environmental Fate and Effects Division (EFED) in the following memorandum: “ Revised DrinkingFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 9 of 27 Water Assessment for the Section 3 Registration of Fluazifop - p - butyl For Use on bananas, plantains, citrus, grapes, and sugar beets pre - bloom and p ost - bloom ( Wm. J. Shaughnessy , D371093, 05/25/2010 ) and incorporated directly

into this dietary

assessment. Water residues were incorporated in the DEEM FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.” Est imated exposure concentrations (EECs) in ground water were modeled using Tier I SCI GROW (version 2.3, dated July

29, 2003) and surface water EECs were modeled using Tier I I PRZM (Pesticide Root Zone Model; vers. 3.12.2, May 12, 2005) and EXAMS (Exposure An aly sis Modeling Sy stem; Vers. 2.98.04.06). The results of this analy sis are presented in Table 3 . Estimated exposure concentrations represent exposure to fluazifop - acid, with assumptions that fluazifop - acid may b e present in the R or S form or as a mixture of the enantiomers. The results of current assessment are higher than 2008 assessment (DP No. D347521, K. White, 08/04/2008) . For aerial applications the highest surface water EECs reported for peak, 1 in 10 ye ar average, and the 30 year average as estimated by PRZM/EXAMS for all crop use scenarios were 33.4, 6.6 ppb, and 4.4 ppb, respectively . For ground applications the highest EECs for peak, 1 in 10 year average, and the 30 year average were 32.1 ppb, 5.8 ppb, and 3.1 ppb, respectively . SCI - GROW estimated the concentration of fluazifop - acid in shallow ground water sources to be 1.56 ppb . The difference between the 2008 and current assessment results can be attributed to a proposed increase in the maximum number of allowable applications (i.e., 3 vs. 2), and differences in crop use scenarios used in the two assessments. Table 3 . Sum ma ry of the highest predicted surface water and ground water concentrations for the drinking water assessm ent on bananas, pl antains, citrus, grapes, and sugar beets

Use Estim ated Drinking Water Concentration of Fluazifop - Acid (  g/L) Acute or Peak 1 in 10 year Average (Noncancer Chronic) 30 year Average (Cancer Chronic) Aerial Applications Surface Water Bananas & Plantains 33.4 6.2 3.2 Citrus 28.5 5.4 3.7 Grapes 19.8 6.6 4.4 Sugar Beets Ground Applications Surface Wa ter Bananas & Plantains 32.1 5.8 2.7 Citrus 27.3 5.1 2.8 Grapes 16.6 5.3 3.1 Sugar Beets 10.6 3.9 2.3 All Uses Ground Water 1.56 1.56 1.56 

### IV DEEM - FCID  Program and Consumption Information Fluazifop - p - butyl acute and chronic dietary exposure ass essments were conducted using the Dietary ExposureFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 10 of 27 Evaluation Model software with the Food Commodity Intake Database (DEEM - FCID  , Version 2.03), which incorporates consumption data from USDA’s Continuing Survey s of Food Intakes by Individuals (CSFI I), 1994 - 1996 and 1998. The 1994 - 96, 98 data are based on the reported consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly

available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. populat ion and within population subgroups, but for acute exposure assessment are retained as individual consumption events. Based on analysis of the 1994 - 96, 98 CSFI I consumption data, which took into account dietary patterns and survey

respondents, HED conclud ed that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, adults 20 - 49, females 13 - 49, and adults 50+ years old. F or chronic dietary

exposure assessment, an estimate of the residue level in each food or food - form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily

consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure i s expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup. For acute exposure assessments, individual one - day food consumption data are used on an individual - byindividual basis. The rep orted consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then s ummed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per - capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy , per capita exposure and risk are reported for all tiers of analy sis. However, for tiers 1 and 2, any significant differences in user vs. per capita exposure and r isk are specifically identified and noted in the risk assessment. V. Toxicological Information On May 6, 2004, the Health Effects Division (HED) Hazard I dentification Assessment Review Committee (HIARC) reviewed the recommendations of the toxicology rev iewer for Fluazifop - butyl and Fluazifop - p - butyl with regard to the acute and chronic Reference Doses (RfDs) and the toxicological endpoint selection for use as appropriate in occupational/residential exposure risk assessments. The potential for increased susceptibility of infants and children from exposure to Fluazifop - butyl and Fluazifop - p - butyl was also evaluated as required by the Food Quality

Protection Act (FQPA) of 1996 (TXR NO. 0052611; memo dated June 15, 2004 by D. Anderson). The conclusions drawn at this meeting are presented in Table 4 below. Table 4 . Sum ma ry of Toxicological Doses and Endpoints for Fluazifop - p - butyl for Use in Dietary Exposure Assessm entFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

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### Page 11 of 27 Exposure Scenario Dose Used in Risk Assessment, UF Hazard and Exposure

Based FQPA Sa fety Factor Study and Toxicological Effects Acute Dietary (General population including infants and children) An appropriate endpoint attributable to a single dose w as not identified in the available studies including the developmental toxicity studies . Acute Dietary (Females 13 - 49 years of age) NOAEL = 50 mg/kg/day UF = 100 Acute RfD = 0.50 mg/kg FQPA SF = 1X

aPAD = acute RfD FQPA SF = 0.50 mg/kg/day Developm ental Toxicity in rats . LOAEL = 200 mg/kg/day based on diaphragmatic herni a. Chronic Dietary (All populations) NOAEL= 0.74 mg/kg/day UF = 100 Chronic RfD = 0.00 8 mg/kg/day FQPA SF = 1X

cPAD = chronic RfD FQPA SF = 0.0074 mg/kg/day Two - Generation Reproduction in rats . LOAEL = 5.8 mg/kg/day in males and 7.1 in females based on decreased spleen, testes & epididymal weights in males and uterine & pituitary weights in females. Cancer “Not likely to be carcinogenic to humans.” 

### V I . Results/Discussion As stated above, for acute and chronic assessments, HED i s concerned when dietary risk exceeds 100% of the PAD. The DEEM - FCID  analy ses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table s 5 and 6 are for the general U.S. Population, all infants (<1 year old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, females 13 - 49, adults 20 - 49, and adults 50+ years. Results of Acute Dietary Exposure Analysis Dietary risk estimates are presented for the only population subgroup with an acute di etary endpoint, females 13 - 49 years of age ( 13 % aPAD at 9 5.0 th 

### percentile). No acute dietary end p oi nt attributable to a single dose was identified for general population including infants and children. This assessment concludes that for all supported re gistered commodities and new uses, the acute food plus water dietary risk estimates are below the Agency ’s level of concern (<100 % aPAD). This assessment is considered to be conservative. The results are listed below in Table 5 .Fluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

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### Page 12 of 27 Table 5 . Sum ma ry of Acut e Dietary (Food + Drinking Water) Exposure and Risk for Fluazifop - p - butyl Population Subgroup aPAD (m g/kg/day) 95 th Percentile 99th Percentile 99.9th Percentile

Exposure (m g/kg/day ) %

aPAD Exposure

(m g/kg/day) %

aPAD Exposure

(m g/kg/day) %

aPAD Femal e 13 - 49 years old 0.5 0.064 1 13 0.15 15 30 0.367 3 74 

### Results of Chronic Dietary Exposure Analysis This assessment concludes that for all commodities, the chronic food plus water dietary risk estimates are below the Agency ’s level of concern (<100 %cPAD) for the U.S. population ( 12 % cPAD) and all population subgroups. The most highly exposed population subgroup in the chronic dietary exposure analy sis is children 1 - 2 years of age ( 40 % cPAD ). This assessment is still considered to be fairly conservative si nce mean residue estimates were used. Results for all populations considered are listed below in Table 6 .

Table 6 . Sum ma ry of Chronic Dietary (Food + Drinking Water) Exposure and Risk for Fluazifop - p - butyl . Population Subgroup cPAD (m g/kg/day) Expos ure (m g/kg/day) % cPAD General U.S. Population

0.0074 0.0009 12 All Infants (< 1 year old) 0.0015 20 Children 1 - 2 years old 0.003 40 Children 3 - 5 years old 0.0022 30 Children 6 - 12 years old 0.0014 19 Youth 13 - 19 years old 0.0008 11 Adults 20 - 49 years old 0.007 8.9 Adults 50+ years old 0.0006 8.7 Females 13 - 49 years old 0.0006 8.6 

### VI I . Characterization of Inputs/Outputs Anticipated residues for all registered and proposed food commodities were based on field trial data and percent crop treated . Although field trial data provide more refined exposure estimates thanFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 13 of 27 tolerances, the results may still be considered somewhat conservative, since field trials are conducted under maximum use conditions (maximum allowed application rate and numb er of applications, minimum PHI , etc.). VII I . Conclusions A cute and chronic dietary exposure analy ses (including food and water) were performed in order to determine the exposure and risks resulting from the registered uses and new proposed uses of f luazifop - p butyl. Tolerance level values with a ratio adjustment for additional metabolites of concern, default processing factors, and refined point estimates for residues in water were used in these assessments. Percent CT refinements were included for the acute and chronic dietary exposure analy sis . This assessment concludes that for all supported registered commodities and new proposed uses , the acute dietary risk estimates are below the Agency ’s level of concern (<100 %aPAD) for females 13 - 49 years of age (< 13 % aPAD) at the 95 th 

### exposure percentile. Chronic dietary risk estimates are provided for the U.S. population (total) and various population subgroups. The chronic assessment concludes that for all supported commodities and proposed uses , the chronic dietary risk estimates are below the Agency ’s level of concern (<100 %cPAD) for the U.S. population ( 12 % cPAD) and all population subgroups. The most highly

exposed population subgroup in the chronic dietary exposure analy sis is children 1 - 2 year s of age ( 40 % cPAD) . VIII. List of Attachments

· Acute Food plus Water Residue Input file.

· Chronic Food plus Water Residue Input file.

· Acute Results file.

· Chronic Results file.

· Percent Crop Treated Memo from BEADFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 14 of 27 Att achment: Acute Food plus Water Residue Input File Filename: C: \ Documents and Settings \ stadayon \ My Documents \ Work in Progress \ 122809a.R98 Chemical: Fluazifop p butyl RfD(Chronic): 0 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOE L(Acute): 0 mg/kg bw/day Date created/last modified: 07 - 27 - 2010/13:23:34/8 Program ver. 2.03

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 12000120 12 Apricot 0.095000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 12000121 12 Apricot - babyfood 0.095000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 12000130 12 Apricot, dried 0.095000 6.000 1.000 Rat io

Full comment: Ratio from soybean metabolism 12000140 12 Apricot, juice 0.095000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 12000141 12 Apricot, juice - babyfood 0.095000 1.0 00 1.000 Ratio

Full comment: Ratio from soybean metabolism 95000190 O Asparagus 3.360000 1.000 0.010 Ratio

Full comment: Ratio from celery metabolismFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 15 of 27 95000230 O Banana 0 .019000 1.000 1.000 95000231 O Banana - babyfood 0.019000 1.000 1.000 95000240 O Banana, dried 0.019000 1.000 1.000 95000241 O Banana, dried - babyfood 0.019000 1.000 1.000 060303 00 6C Bean, black, seed 95.000000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 06030320 6C Bean, broad, seed 95.000000 1.000 1.000 Ratio

Full comment: Ratio from soybean met abolism 06030340 6C Bean, cowpea, seed 95.000000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 06030350 6C Bean, great northern, seed 95.000000 1.000 1.000 Ratio

Full comment: Ratio fr om soybean metabolism 06030360 6C Bean, kidney, seed 95.000000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 06030380 6C Bean, lima, seed 95.000000 1.000 1.000 Ratio

Full com ment: Ratio from soybean metabolism 06030390 6C Bean, mung, seed 95.000000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 06030400 6C Bean, navy, seed 95.000000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 06030410 6C Bean, pink, seed 95.000000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 06030420 6C Bean, pinto, seed 95.000000 1.000 1.00 0 Ratio

Full comment: Ratio from soybean metabolism 21000440 M Beef, meat 0.050000 1.000 1.000 21000441 M Beef, meat - babyfood 0.050000 1.000 1.000 21000450 M Beef, meat, dried 0.050000 1.920 1.000 21000460 M Beef, meat byproducts 0.050000 1.000 1.000 21000461 M Beef, meat byproducts - babyfood 0.050000 1.000 1.000 21000470 M Beef, fat 0.050000 1.000 1.000 21000471 M Beef,fat - babyfood 0.050000 1.000 1.000 21000480 M Beef, kidney 0.050000 1.000 1.000 21000490 M Beef, liver 0.050000 1.000 1.000 21000491 M Beef, liver - bab yfood 0.050000 1.000 1.000 01010500 1AB Beet, garden, roots 0.475000 1.000 1.000 01010501 1AB Beet, garden, roots - babyfood 0.475000 1.000 1.000 02000510 2 Beet, garden, tops 2.850000 1.000 1.000 01010520 1A Beet, sugar 0.475000 1.000 1.000 01010521 1A Beet, sugar - babyfood 0.475000 1.000 1.000 01010530 1A Beet, sugar, molasses 6.650000 1.000 1.000 01010531 1A Be et, sugar, molasses - babyfood 6.650000 1.000 1.000 01010780 1AB Carrot 2.500000 1.000 0.100 Ratio

Full comment: Ratio from carrot metabolism 01010781 1AB Carrot - babyfood 2.500000 1.0 00 0.100 Ratio

Full comment: Ratio from carrot metabolism 01010790 1AB Carrot, juice 2.500000 1.000 0.100 Ratio

Full comment: Ratio from carrot metabolism 12000900 12 Cherry 0. 095000 1.000 1.000 12000901 12 Cherry - babyfood 0.095000 1.000 1.000 12000910 12 Cherry, juice 0.095000 1.500 1.000 12000911 12 Cherry, juice - babyfood 0.095000 1.500 1.000 4000093 0 P Chicken, meat 0.050000 1.000 1.000 40000931 P Chicken, meat - babyfood 0.050000 1.000 1.000 40000940 P Chicken, liver 0.050000 1.000 1.000 40000950 P Chicken, meat byproducts 0.050000 1.000 1.000 40000951 P Chicken, meat byproducts - babyfoo 0.050000 1.000 1.000 40000960 P Chicken, fat 0.050000 1.000 1.000Fluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 16 of 27 40000961 P Chicken, fat - babyfood 0.050000 1.000 1. 000 40000970 P Chicken, skin 0.050000 1.000 1.000 40000971 P Chicken, skin - babyfood 0.050000 1.000 1.000 06030980 6C Chickpea, seed 95.000000 1.000 1.000 06030981 6C Chickpea, s eed - babyfood 95.000000 1.000 1.000 06030990 6C Chickpea, flour 95.000000 1.000 1.000 10001060 10 Citrus citron 0.100000 1.000 1.000 10001070 10 Citrus hybrids 0.10000 0 1.000 1.000 10001080 10 Citrus, oil 0.100000 1.000 1.000 95001150 O Coffee, roasted bean 0.190000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 95001160 O Coffee, insta nt 0.190000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 95001280 O Cottonseed, oil 0.380000 1.000 0.025 Ratio

Full comment: Ratio from soybean metabolism 95001281 O Cottonseed, oil - babyfood 0.380000 1.000 0.025 Ratio

Full comment: Ratio from soybean metabolism 70001450 P Egg, whole 0.050000 1.000 1.000 70001451 P Egg, whole - babyfood 0.050000 1.000 1.000 70001460 P Egg, white 0.050000 1.000 1.000 70001461 P Egg, white (solids) - babyfood 0.050000 1.000 1.000 70001470 P Egg, yolk 0.050000 1.000 1.000 70001471 P E gg, yolk - babyfood 0.050000 1.000 1.000 04011500 4A Endive 6.960000 1.000 1.000 03001640 3 Garlic 0.625000 1.000 1.000 03001650 3 Garlic, dried 0.625000 9.000 1.000 03001651 3 Garlic, dried - babyfood 0.625000 9.000 1.000 23001690 M Goat, meat 0.050000 1.000 1.000 23001700 M Goat, meat byproducts 0.050000 1.000 1.000 23 001710 M Goat, fat 0.050000 1.000 1.000 23001720 M Goat, kidney 0.050000 1.000 1.000 23001730 M Goat, liver 0.050000 1.000 1.000 13021740 13B Gooseberry 0.019000 1.000 1.000 95001750 O Grape 0.019000 1.000 1.000 95001760 O Grape, juice 0.019000 1.000 1.000 95001761 O Grape, juice - babyfood 0.019000 1.00 0 1.000 95001770 O Grape, leaves 0.019000 1.000 1.000 95001780 O Grape, raisin 0.019000 1.000 1.000 95001790 O Grape, wine and sherry 0.019000 1.000 1.000 10001800 10 Grapef ruit 0.100000 1.000 1.000 10001810 10 Grapefruit, juice 0.100000 1.000 1.000 06031820 6C Guar, seed 95.000000 1.000 1.000 06031821 6C Guar, seed - babyfood 95. 000000 1.000 1.000 10001970 10 Kumquat 0.100000 1.000 1.000 10001990 10 Lemon 0.100000 1.000 1.000 10002000 10 Lemon, juice 0.100000 1.000 1.000 1000200 1 10 Lemon, juice - babyfood 0.100000 1.000 1.000 10002010 10 Lemon, peel 0.100000 1.000 1.000 06032030 6C Lentil, seed 95.000000 1.000 1.000 10002060 10 Lime 0.100000 1.000 1.000 10002070 10 Lime, juice 0.100000 1.000 1.000 10002071 10 Lime, juice - babyfood 0.100000 1.000 1.000 14002130 14 Macadamia nut 0.190000 1.000 1. 000 Ratio

Full comment: Ratio from soybean metabolism 27002220 D Milk, fat 0.050000 1.000 1.000 27002221 D Milk, fat - baby food/infant for 0.050000 1.000 1.000 27012230 D Milk, nonfat solids 0.050000 1.000 1.000Fluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 17 of 27 27012231 D Milk, nonfat solids - baby food/in 0.050000 1.000 1.000 27022240 D Milk, water 0.050000 1.000 1.000 27022241 D Milk, water - babyfood/infant form 0.050000 1.000 1.00 0 27032251 D Milk, sugar (lactose) - baby food/ 0.050000 1.000 1.000 12002300 12 Nectarine 0.095000 1.000 1.000 03002370 3 Onion, dry bulb 0.625000 1.000 0.150 Ratio

Full commen t: Ratio from carrot metabolism 03002371 3 Onion, dry bulb - babyfood 0.625000 1.000 0.150 Ratio

Full comment: Ratio from carrot metabolism 03002380 3 Onion, dry bulb, dried 0.625000 9.000 0.150 Ratio

Full comment: Ratio from carrot metabolism 03002381 3 Onion, dry bulb, dried - babyfood 0.625000 9.000 0.150 Ratio

Full comment: Ratio from carrot metabolism 10002400 10 Orange 0.100000 1.000 1.000 100 02410 10 Orange, juice 0.100000 1.000 1.000 10002411 10 Orange, juice - babyfood 0.100000 1.000 1.000 10002420 10 Orange, peel 0.100000 1.000 1.000 12002600 12 Peach 0.095000 1.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 12002601 12 Peach - babyfood 0.095000 1.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 12002610 12 Peach, dried 0.095000 7.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 12002611 12 Peach, dried - babyfood 0.095000 7.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 120026 20 12 Peach, juice 0.095000 1.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 12002621 12 Peach, juice - babyfood 0.095000 1.000 0.010 Ratio

Full comment: Ratio from soybean met abolism 95002630 O Peanut 2.850000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 95002640 O Peanut, butter 2.850000 1.890 1.000 Ratio

Full comment: Ratio fr om soybean metabolism 95002650 O Peanut, oil 2.850000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 14002690 14 Pecan 0.095000 1.000 1.000 08002720 8 Pepper, no nbell 1.120000 1.000 1.000 Ratio

Full comment: Ratio from celery metabolism 08002721 8 Pepper, nonbell - babyfood 1.120000 1.000 1.000 Ratio

Full comment: Ratio from celery metabolism 08002730 8 Pepper, nonbell, dried 1.120000 1.000 1.000 Ratio

Full comment: Ratio from celery metabolism 12002850 12 Plum 0.095000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 12002851 12 Plum - babyfood 0.095000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 12002860 12 Plum, prune, fresh 0.095000 1.000 1.000 Ratio

Full comment: Ratio from soyb ean metabolism 12002861 12 Plum, prune, fresh - babyfood 0.095000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 12002870 12 Plum, prune, dried 0.095000 5.000 1.000 Ratio

Full comment: R atio from soybean metabolism 12002871 12 Plum, prune, dried - babyfood 0.095000 5.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 12002880 12 Plum, prune, juice 0.095000 1.400 1.000 Ratio

F ull comment: Ratio from soybean metabolism 12002881 12 Plum, prune, juice - babyfood 0.095000 1.400 1.000 RatioFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 18 of 27

Full comment: Ratio from soybean metabolism 25002900 M Pork, meat 0.050000 1.000 1.000 250 02901 M Pork, meat - babyfood 0.050000 1.000 1.000 25002910 M Pork, skin 0.050000 1.000 1.000 25002920 M Pork, meat byproducts 0.050000 1.000 1.000 25002921 M Pork, meat byproduct s - babyfood 0.050000 1.000 1.000 25002930 M Pork, fat 0.050000 1.000 1.000 25002931 M Pork, fat - babyfood 0.050000 1.000 1.000 25002940 M Pork, kidney 0.050000 1.000 1.000 25002950 M Pork, liver 0.050000 1.000 1.000 01032960 1C Potato, chips 1.250000 3.300 1.000 01032970 1C Potato, dry (granules/ flakes) 1.250000 6.400 1.000 01032971 1C Potato, dry (granules/ flakes) - b 1.250000 6.400 1.000 01032980 1C Potato, flour 1.250000 6.400 1.000 01032981 1C Potato, flour - babyfood 1.250000 6.400 1.000 01032990 1C Potato, tuber, w/peel 1.2 50000 1.400 1.000 01032991 1C Potato, tuber, w/peel - babyfood 1.250000 1.400 1.000 01033000 1C Potato, tuber, w/o peel 1.250000 1.400 1.000 01033001 1C Potato, tuber, w/o peel - babyfood 1.250000 1.400 1.000 60003010 P Poultry, other, meat 0.050000 1.000 1.000 60003020 P Poultry, other, liver 0.050000 1.000 1.000 60003030 P Poultry, other, meat byproducts 0.050000 1.000 1.000 60003040 P Poultry, other, fat 0.050000 1.000 1.000 60003050 P Poultry, other, skin 0.050000 1.000 1.000 10003070 10 Pummelo 0.050000 1.000 1.000 04023220 4B Rhubarb 0.560000 1.000 1.0 00 Ratio

Full comment: Ratio from celery metabolism 26003390 M Sheep, meat 0.050000 1.000 1.000 26003391 M Sheep, meat - babyfood 0.050000 1.000 1.000 26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 26003410 M Sheep, fat 0.050000 1.000 1.000 26003411 M Sheep, fat - babyfood 0.050000 1.000 1.000 26003420 M Sheep, kidney 0.050000 1.000 1.000 26003430 M Sheep, liver 0.050000 1.000 1.000 06003470 6 Soybean, seed 4.750000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 06003480 6 Soybean, flour 4.750000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 06003481 6 Soybean, flour - babyfood 4.750000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 06003490 6 Soybean, soy mil k 4.750000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 06003491 6 Soybean, soy milk - babyfood or in 4.750000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 06003500 6 So ybean, oil 4.750000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 06003501 6 Soybean, oil - babyfood 4.750000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 04 013550 4A Spinach 6.960000 1.000 1.000 Ratio

Full comment: Ratio from celery metabolism 04013551 4A Spinach - babyfood 6.960000 1.000 1.000 Ratio

Full comment: Ratio from celery m etabolism 01033660 1CD Sweet potato 1.250000 1.000 1.000 Ratio

Full comment: Ratio from carrot metabolism 01033661 1CD Sweet potato - babyfood 1.250000 1.000 1.000 Ratio

Full comment: Ratio f rom carrot metabolism 10003690 10 Tangerine 0.050000 1.000 1.000Fluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 19 of 27 10003700 10 Tangerine, juice 0.050000 1.000 1.000 50003820 P Turkey, meat 0.050000 1.000 1.000 50003821 P Turkey, meat - babyfood 0.050000 1.000 1.000 50003830 P Turkey, liver 0.050000 1.000 1.000 50003831 P Turkey, liver - babyfood 0.050000 1.000 1.000 50003840 P Turkey, meat byproducts 0.050000 1.000 1.000 50003841 P Turkey, meat byproducts - babyfood 0.050000 1.000 1.000 50003850 P Turkey, fat 0.050000 1.000 1.000 50003851 P Turkey, fat - babyfood 0.050000 1.000 1.00 0 50003860 P Turkey, skin 0.050000 1.000 1.000 50003861 P Turkey, skin - babyfood 0.050000 1.000 1.000 86010000 O Water, direct, all sources 0.033400 1.000 1.000 86020000 O Water, indire ct, all sources 0.033400 1.000 1.000 01034060 1CD Yam, true 1.250000 1.000 1.000 01034070 1CD Yam bean 1.250000 1.000 1.000



### Attachment: Chronic Food plus Water Residue I nput File Filename: C: \ Documents and Settings \ stadayon \ My Documents \ Work in Progress \ 122809c 2010 .R98 Chemical: Fluazifop p butyl RfD(Chronic): 0 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date cre ated/last modified: 07 - 28 - 2010/07:57:28/8 Program ver. 2.03

-------------------------------------------------------------------------------- Note: No residue distributions have been assigned to Commodities/FoodForms below EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 95000190 O Asparagus 0.640000 1.000 0.025 Ratio

Full comment: Ratio from celery metabolism 95001150 O Coffee, roasted bean 0.190000 1.000 1.900 Ratio

Full comment: Ratio from soybean metabolism 95001160 O Coffee, instant 0.190000 1.000 1.900 Ratio

Full comment: Ratio from soybean metabolism 95001280 O Cottonseed, oil 0.380000 1.000 0.025 Ratio

Full comment: Ratio from soybean metabolism 95001281 O Co ttonseed, oil - babyfood 0.380000 1.000 0.025 Ratio

Full comment: Ratio from soybean metabolism 95001750 O Grape 0.005000 1.000 1.900 95001760 O Grape, juice 0.005000 1. 000 1.900 95001761 O Grape, juice - babyfood 0.005000 1.000 1.900Fluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 20 of 27 95001770 O Grape, leaves 0.005000 1.000 1.900 95001780 O Grape, raisin 0.005000 1.000 1.900 95001790 O Grap e, wine and sherry 0.005000 1.000 1.900 95002630 O Peanut 0.760000 1.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 95002640 O Peanut, butter 0.760000 1.89 0 0.010 Ratio

Full comment: Ratio from soybean metabolism 95002650 O Peanut, oil 0.760000 0.010 0.010 Ratio

Full comment: Ratio from soybean metabolism 86010000 O Water, direct, all sources 0 .006600 1.000 1.000 86020000 O Water, indirect, all sources 0.006600 1.000 1.000 21000440 M Beef, meat 0.050000 1.000 1.000 21000441 M Beef, meat - babyfood 0.050000 1.000 1.000 210004 50 M Beef, meat, dried 0.050000 1.920 1.000 21000460 M Beef, meat byproducts 0.050000 1.000 1.000 21000461 M Beef, meat byproducts - babyfood 0.050000 1.000 1.000 21000470 M Beef, fat 0.050000 1.000 1.000 21000471 M Beef,fat - babyfood 0.050000 1.000 1.000 21000480 M Beef, kidney 0.050000 1.000 1.000 21000490 M Beef, liver 0.050000 1.000 1 .000 21000491 M Beef, liver - babyfood 0.050000 1.000 1.000 23001690 M Goat, meat 0.050000 1.000 1.000 23001700 M Goat, meat byproducts 0.050000 1.000 1.000 23001710 M Goat, fat 0.050000 1.000 1.000 23001720 M Goat, kidney 0.050000 1.000 1.000 23001730 M Goat, liver 0.050000 1.000 1.000 25002900 M Pork, meat 0.0500 00 1.000 1.000 25002901 M Pork, meat - babyfood 0.050000 1.000 1.000 25002910 M Pork, skin 0.050000 1.000 1.000 25002920 M Pork, meat byproducts 0.050000 1.000 1.000 25002921 M Pork, meat byproducts - babyfood 0.050000 1.000 1.000 25002930 M Pork, fat 0.050000 1.000 1.000 25002931 M Pork, fat - babyfood 0.050000 1.000 1.000 25002940 M Pork, kidney 0.050000 1.000 1.000 25002950 M Pork, liver 0.050000 1.000 1.000 26003390 M Sheep, meat 0.050000 1.000 1.000 26003391 M Sheep, meat - babyfood 0.050000 1.000 1.000 26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 26003410 M Sheep, fat 0.050000 1.000 1.000 26003411 M Sheep, fat - babyfood 0.050000 1.000 1.000 26003420 M Sheep, kidney 0.050000 1.000 1.000 26003430 M Sheep, liver 0.050000 1.000 1.000 40000930 P Chicken, meat 0.050000 1.000 1.000 40000931 P Chicken, meat - babyfood 0.050000 1.000 1.000 40000940 P Chicken, liver 0.050000 1.000 1.000 40000950 P Chicken, meat byproducts 0.050000 1.000 1.000 40000951 P Chicken, meat byproducts - babyfoo 0.050000 1.000 1.000 40000960 P Ch icken, fat 0.050000 1.000 1.000 40000961 P Chicken, fat - babyfood 0.050000 1.000 1.000 40000970 P Chicken, skin 0.050000 1.000 1.000 40000971 P Chicken, skin - babyfood 0.050000 1.000 1.000 70001450 P Egg, whole 0.050000 1.000 1.000 70001451 P Egg, whole - babyfood 0.050000 1.000 1.000 70001460 P Egg, white 0.050000 1.000 1.000 700 01461 P Egg, white (solids) - babyfood 0.050000 1.000 1.000 70001470 P Egg, yolk 0.050000 1.000 1.000 70001471 P Egg, yolk - babyfood 0.050000 1.000 1.000Fluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 21 of 27 60003010 P Poultry, other, meat 0.050000 1.000 1.000 60003020 P Poultry, other, liver 0.050000 1.000 1.000 60003030 P Poultry, other, meat byproducts 0.050000 1.000 1.000 60003040 P Poultry, other, fat 0.050000 1.000 1.000 60003050 P Poultry, other, skin 0.050000 1.000 1.000 50003820 P Turkey, meat 0.050000 1.000 1.000 50003821 P Turkey, meat - babyfood 0.050000 1.000 1.000 50003830 P Turkey, liver 0.050000 1.000 1.000 50003831 P Turkey, liver - babyfood 0.050000 1.000 1.000 50003840 P Turkey, meat byproducts 0.050000 1.000 1.000 50003841 P Turkey, meat byproducts - babyfood 0.0 50000 1.000 1.000 50003850 P Turkey, fat 0.050000 1.000 1.000 50003851 P Turkey, fat - babyfood 0.050000 1.000 1.000 50003860 P Turkey, skin 0.050000 1.000 1.000 50003861 P Turkey, skin - babyfood 0.050000 1.000 1.000 27002220 D Milk, fat 0.050000 1.000 1.000 27002221 D Milk, fat - baby food/infant for 0.050000 1.000 1.000 27012230 D Milk, nonfat solids 0.050000 1.000 1.000 27012231 D Milk, nonfat solids - baby food/in 0.050000 1.000 1.000 27022240 D Milk, water 0.050000 1.000 1.000 27022241 D Milk, water - babyfood/infant form 0.050000 1.000 1.0 00 27032251 D Milk, sugar (lactose) - baby food/ 0.050000 1.000 1.000 01010500 1AB Beet, garden, roots 0.080000 1.000 1.900 01010501 1AB Beet, garden, roots - babyfood 0.080000 1.000 1.900 01010520 1A Beet, sugar 0.080000 1.000 1.900 01010521 1A Beet, sugar - babyfood 0.080000 1.000 1.900 01010530 1A Beet, sugar, molasses 0.080000 1.000 1.900 01010531 1A Beet, sugar, molasses - babyfood 0.080000 1.000 1.900 01010780 1AB Carrot 0.038000 1.000 0.100 Ratio

Full comment: Ratio from carrot metabolism 01010781 1AB Carrot - babyfood 0.038000 1.000 0.100 Ratio

Full comment: Ratio from carrot metabolism 01010790 1AB Carrot, juice 0.038000 1.500 0.100 Ratio

Full comment: Ratio from carrot metabolism 01032960 1C Potato, chips 0.110000 3.300 1.250 01032970 1C Pot ato, dry (granules/ flakes) 0.110000 6.400 1.250 01032971 1C Potato, dry (granules/ flakes) - b 0.110000 6.400 1.250 01032980 1C Potato, flour 0.110000 6.400 1.250 01032981 1C Potato, flour - babyfood 0.110000 6.400 1.250 01032990 1C Potato, tuber, w/peel 0.110000 1.400 1.250 01032991 1C Potato, tuber, w/peel - babyfood 0.110000 1.400 1.250 01033000 1C Potato, tuber, w/o peel 01033001 1C Potato, tuber, w/o peel - bab yfood 0.110000 1.400 1.250 01033660 1CD Sweet potato 0.110000 1.000 1.250 Ratio

Full comment: Ratio from carrot metabolism 01033661 1CD Sweet potato - babyfood 0.110000 1.000 1.250 Ratio

Full comment: Ratio from carrot metabolism 01034060 1CD Yam, true 0.110000 1.000 1.250 01034070 1CD Yam bean 0.110000 1.000 1.250 02000510 2 Beet, garden, tops 1.300000 1.000 1.900 03001640 3 Garlic 0.038000 1.000 0.050 03001650 3 Garlic, dried 0.038000 9.000 0.050 03001651 3 Garlic, dried - babyfood 0.038000 9.000 0.050 03002370 3 On ion, dry bulb 0.038000 1.000 0.150 Ratio

Full comment: Ratio from carrot metabolism 03002371 3 Onion, dry bulb - babyfood 0.038000 1.000 0.150 Ratio

Full comment: Ratio from carrot metabolismFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 22 of 27 0300 2380 3 Onion, dry bulb, dried 0.038000 9.000 0.150 Ratio

Full comment: Ratio from carrot metabolism 03002381 3 Onion, dry bulb, dried - babyfood 0.038000 9.000 0.150 Ratio

Full comment: Ratio from carrot met abolism 04011500 4A Endive 0.050000 1.000 1.160 04023220 4B Rhubarb 0.190000 1.000 1.120 Ratio

Full comment: Ratio from celery metabolism 04013550 4A Spinach 0.050000 1.000 1.160 Ratio

Full comment: Ratio from celery metabolism 04013551 4A Spinach - babyfood 0.050000 1.000 1.160 Ratio

Full comment: Ratio from celery metabolism 06030300 6C Bean, black, seed 10.260000 1.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 06030320 6C Bean, broad, seed 10.260000 1.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 06030340 6C Bean, cowpea, seed 10.260000 1.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 06030350 6C Bean, great northern, seed 10.260000 1.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 06030360 6C Bean, kidney, seed 10.260000 1.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 06030380 6C Bean, lima, seed 10.260000 1.000 0.010 Ratio

Full comment: Ratio from soyb ean metabolism 06030390 6C Bean, mung, seed 10.260000 1.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 06030400 6C Bean, navy, seed 10.260000 1.000 0.010 Ratio

Full comment: R atio from soybean metabolism 06030410 6C Bean, pink, seed 10.260000 1.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 06030420 6C Bean, pinto, seed 10.260000 1.000 0.010 Ratio

F ull comment: Ratio from soybean metabolism 06030980 6C Chickpea, seed 10.260000 1.000 0.010 06030981 6C Chickpea, seed - babyfood 10.260000 1.000 0.010 06030990 6C Chickpea, flour 10.260000 1.0 00 0.010 06031820 6C Guar, seed 10.260000 1.000 0.010 06031821 6C Guar, seed - babyfood 10.260000 1.000 0.010 06032030 6C Lentil, seed 10.260000 1.000 0.010 06003470 6 Soybe an, seed 1.900000 1.000 0.025 Ratio

Full comment: Ratio from soybean metabolism 06003480 6 Soybean, flour 1.900000 1.000 0.025 Ratio

Full comment: Ratio from soybean metabolism 06003 481 6 Soybean, flour - babyfood 1.900000 1.000 0.025 Ratio

Full comment: Ratio from soybean metabolism 06003490 6 Soybean, soy milk 1.900000 1.000 0.025 Ratio

Full comment: Ratio from soybean me tabolism 06003491 6 Soybean, soy milk - babyfood or in 1.900000 1.000 0.025 Ratio

Full comment: Ratio from soybean metabolism 06003500 6 Soybean, oil 1.900000 0.010 0.025 Ratio

Full comment: Ratio f rom soybean metabolism 06003501 6 Soybean, oil - babyfood 1.900000 0.010 0.025 Ratio

Full comment: Ratio from soybean metabolism 08002720 8 Pepper, nonbell 0.670000 1.000 0.010 Ratio

Full co mment: Ratio from celery metabolism 08002721 8 Pepper, nonbell - babyfood 0.670000 1.000 0.010 Ratio

Full comment: Ratio from celery metabolism 08002730 8 Pepper, nonbell, dried 0.670000 1.000 0.010 Ratio

Full comment: Ratio from celery metabolismFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 23 of 27 10001060 10 Citrus citron 0.005000 1.000 1.900 10001070 10 Citrus hybrids 0.005000 1.000 1.900 10001080 10 Citrus, oil 0.005000 1.000 1.900 10001800 10 Grapefruit 0.005000 1.000 1.900 10001810 10 Grapefruit, juice 0.005000 1.000 1.900 10001970 10 Kumquat 0.005000 1.000 1.900 10001990 10 Lemon 0.005000 1.000 1.900 10002000 10 Lemon, juice 0.005000 1.000 1.900 10002001 10 Lemon, juice - babyfood 0.005000 1.000 1.900 10002010 10 Lemon, peel 0.005000 1.000 1.900 10002060 10 Lime 0.005000 1.000 1.900 10002070 10 Lime, juice 0.005000 1.000 1.900 10002071 10 Lime, juice - babyfood 0.005000 1.000 1.900 1 0002400 10 Orange 0.005000 1.000 1.900 10002410 10 Orange, juice 0.005000 1.000 1.900 10002411 10 Orange, juice - babyfood 0.005000 1.000 1.900 10002420 10 Orange, peel 0.005000 1.000 1.900 10003070 10 Pummelo 0.005000 1.000 1.900 10003690 10 Tangerine 0.005000 1.000 1.900 10003700 10 Tangerine, juice 0.005000 1.0 00 1.900 12000120 12 Apricot 0.015000 1.000 1.900 Ratio

Full comment: Ratio from soybean metabolism 12000121 12 Apricot - babyfood 0.015000 1.000 1.900 Ratio

Full comment: Rati o from soybean metabolism 12000130 12 Apricot, dried 0.015000 6.000 1.900 Ratio

Full comment: Ratio from soybean metabolism 12000140 12 Apricot, juice 0.015000 1.000 1.900 Ratio

Full comment: Ratio from soybean metabolism 12000141 12 Apricot, juice - babyfood 0.015000 1.000 1.900 Ratio

Full comment: Ratio from soybean metabolism 12000900 12 Cherry 0.029000 1.000 0.010 120009 01 12 Cherry - babyfood 0.029000 1.000 0.010 12000910 12 Cherry, juice 0.029000 1.500 0.010 12000911 12 Cherry, juice - babyfood 0.029000 1.500 0.010 12002300 12 Nectarine 0.015000 1.000 1.900 12002600 12 Peach 0.029000 1.000 0.025 Ratio

Full comment: Ratio from soybean metabolism 12002601 12 Peach - babyfood 0.029000 1.000 0.025 Ratio

Full comment: Ratio from soybean metabolism 12002610 12 Peach, dried 0.029000 7.000 0.025 Ratio

Full comment: Ratio from soybean metabolism 12002611 12 Peach, dried - babyfood 0.029000 7.000 0. 025 Ratio

Full comment: Ratio from soybean metabolism 12002620 12 Peach, juice 0.029000 1.000 0.025 Ratio

Full comment: Ratio from soybean metabolism 12002621 12 Peach, juice - babyfood 0.0290 00 1.000 0.025 Ratio

Full comment: Ratio from soybean metabolism 12002850 12 Plum 0.019000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 12002851 12 Plum - babyfood 0.019000 1.000 1.000 Ratio

Full comment: Ratio from soybean metabolism 12002860 12 Plum, prune, fresh 0.019000 1.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 12002861 12 Plum, prune, fresh - babyfood 0.019000 1.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 12002870 12 Plum, prune, dried 0.019000 5.000 0.010 Ratio

Full comment: Ratio from soybean metabolismFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 24 of 27 12002871 12 Plum, prune, dried - babyfood 0.019000 5.000 0.010 Ratio

Full comment: Ratio from soybean metabolism 12002880 12 Plum, prune, juice 0.019000 1.400 0.010 Ratio

Full comment: Ratio from soybean metabolism 12002881 12 Plum, prune, juice - babyfood 0.019000 1.400 0.010 Ratio

Full comment: Ratio from soybean metabolism 14002130 14 Macadamia nut 0.050000 1.000 1.900 Ratio

Full comment: Ratio from soyb ean metabolism 14002690 14 Pecan 0.050000 1.000 1.900



### A ttachment: Acute Food plus Water Results File U.S. Environmental Protection Agency Ver. 2.02 DEEM - FCID ACUTE Analysis for FLUAZIFOP P BUTYL (1994 - 98 data) Residue file: 122809a.R98 Adjustment factor #2 NOT used. Analysis Date: 07 - 27 - 2010/14:01:47 Residue file dated: 07 - 27 - 2010/13:23:34/8 Daily totals for food and foodform cons umption used. Run Comment: ""
=============================================================================== Summary calculations (per capita): 95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- Females 13 - 49 yrs: 0.064111 12.82 0.151503 30.30 0.367295 73.46 

### Attachment: Chronic Foo d plus Water Results File U.S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for FLUAZIFOP P BUTYL (1994 - 98 data) Residue file name: C: \ Documents and Settings \ stadayon \ My Documents \ Wor k in Progress \ 122809c 2010 .R98 Adjustment factor #2 used. Analysis Date 07 - 28 - 2010/07:59:35 Residue file dated: 07 - 28 - 2010/07:57:28/8 Reference dose (RfD, Chronic) = .0074 mg/kg bw/day

================================================================== ============= Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

-----------------------------------Fluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 25 of 27

Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.000904 12.2% U.S. Population (spring season) 0.000903 12.2% U.S. Population (summer season) 0.000885 12.0% U.S. Population ( autumn season) 0.000925 12.5% U.S. Population (winter season) 0.000902 12.2% Northeast region 0.000874 11.8% Midwest region 0.0009 63 13.0% Southern region 0.000853 11.5% Western region 0.000949 12.8% Hispanics 0.001045 14.1% Non - hispa nic whites 0.000887 12.0% Non - hispanic blacks 0.000856 11.6% Non - hisp/non - white/non - black 0.000980 13.2% All infants (< 1 year) 0.001482 20.0% Nursing infants 0.000521 7.0% Non - nursing infants 0.001846 25.0% Children 1 - 6 yrs 0.002423 32.7% Ch ildren 7 - 12 yrs 0.001322 17.9% Females 13 - 19 (not preg or nursing) 0.000685 9.3% Females 20+ (not preg or nursing) 0.000624 8.4% Females 13 - 50 yrs 0.000708 9.6% Females 13+ (preg/not nursing) 0.000785 10.6% Females 13+ (nursing) 0.000879 11.9% Males 13 - 19 yrs 0.000883 11.9% Males 20+ yrs 0.000680 9.2% Seniors 55+ 0.000644 8.7% Children 1 - 2 yrs 0.002988 40.4% Children 3 - 5 yrs 0.002231 30.1% Children 6 - 12 yrs 0.001406 19.0% Youth 13 - 19 yrs 0.000787 10.6% Adults 20 - 49 yrs 0.000659 8.9% Adults 50+ yrs 0.000643 8.7% Females 13 - 49 yrs 0.000639 8.6%

-------------------------------------------------------------------------------

-------------- ---------------------------------------------------------------Fluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 26 of 27 Attachment Percent Crop Treated Memo from BEADFluazifop - p - butyl Dietary Exposure Assessment DP Bar code: D 379452

PC Code: 122809



### Page 27 of 27