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# (2,000) are all greater than the re spective target MOEs, therefore the risks ar e not of concern on

an individual basis.

In the previous human health risk assessment, a short term aggregate risk of 3.1 for adults was

determined as shown in Table 1 by aggregati ng the food and water exposures with the post

application inhalation exposures from metered release devices. Because the MOE of 370 for

post application inhalation exposures from mete red release devices is less than the MOE of

400,000 for application of pet sprays , the aggregate risk would not change as a result of the

increased pet spray application rate, and, theref ore, it is not necessary to recalculate the

aggregate risk for adults.

In the previous risk assessment, a short term aggregate risk of 0.96 for children was determined

by aggregating the food and water exposures with the incidental oral exposure from playing on

vinyl floors after fogger treatmen t and the inhalation exposures fr om the use of meter release

devices. Because the incidental or al MOE of 2,000 for playing with treated pets is less than the

incidental oral MOE of 6,900 for playing on vinyl fl oors, the aggregate risk is reduced to 0.82 as

shown in bold text in Table 1. This risk is of concern because it is significantly less than 1.0.

As discussed in the Pyrethrin RED of June 2006, the Pyrethrin Joint Venture agreed to remove

the following use sites from their metered re lease product labels: day care centers, nursing

homes, schools and hospitals. In addition, EPA is requiring air concentration and particle size

data for indoor metered release devices and will prohibit metered release de vice use in residential

areas unless data are submitted in a timely fash ion. Given the above, the metered release

scenario could be deleted from the aggregate ri sk calculation as shown in Table 2. The next

highest inhalation exposure is from space sprays with short term MOEs of 2,100 for adults and

640 for toddlers. The aggregate risks range from 1.8 for children to 10 for adult females and are

not of concern because they are greater than 1.0.Page 3 of 4Table 1. Short-Term Aggregate Risk Calculations (Includes pet spray incidentaloral exposure with rate increase)PopulationFood +WaterExposureIncidentalOralExposureTotalIncidentalOral + Food+ WaterExposureMOEFood +Water+IncidentalOralARIFood + Water+Incidental Oral1MOEInhalationARIInhalation1AggregateARI2Adult Male 0.0037 0 0.0037 5405 18 370 3.7 3.1Adult Female 0.0034 0 0.0034 5850 20 370 3.7 3.1Child 0.011 0.010 0.026 770 2.6 120 1.2 0.82Non-hisp/non-white/ nonblack(Highest ExposedAdult Subpop)0.0069 0 0.0069 2900 9.7 370 3.7 2.71ARI = [MOECALCULATED( i.e., FOOD, WATER, DERMAL, INHALATION, ORAL)÷ MOEACCEPTABLE] (Note: Target ARI > 1)2Aggregate ARI = 1__________1+ 1______ARIFOOD +WATER+ORALARIINHALATION*Note – Values in bold are based on theincidental oral exposure from treated pets at the increased rate of 0.2 percent.Page 4 of 4Table 2. Short-Term Aggregate Risk Calculations(Includes pet spray with rate increase and substitution of space spray inhalation exposure for metered release inhalation exposure)PopulationFood +WaterExposureIncidentalOralExposureTotalIncidentalOral + Food+ WaterExposureMOEFood +Water+IncidentalOralARIFood + Water+Incidental Oral1MOEInhalationARIInhalation1AggregateARI2Adult Male 0.0037 0 0.0037 5405 18 2100 21 9.6Adult Female 0.0034 0 0.0034 5850 20 2100 21 10Child 0.011 0.010 0.026 770 2.6 640 6.4 1.8Non-hisp/non-white/ nonblack(Highest ExposedAdult Subpop)0.0069 0 0.0069 2900 9.7 2100 21 6.61ARI = [MOECALCULATED( i.e., FOOD, WATER, DERMAL, INHALATION, ORAL)÷ MOEACCEPTABLE] (Note: Target ARI > 1)2Aggregate ARI = 1__________1+ 1______ARIFOOD +WATER+ORALARIINHALATION*Note – Values in bold are based on the incidental oral exposure from treated pets and inhalation exposure from space sprays.