EX-4.2





 Exhibit 4.2 

THIS WARRANT AND THE CLASS A COMMON SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
“ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR IN FORM AND
SUBSTANCE SATISFACTORY TO THE COMPANY, SUCH OFFER, SALE, PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION. 
 THIS WARRANT AND THE
CLASS A COMMON SHARES REPRESENTED BY THIS WARRANT ARE SUBJECT TO CERTAIN RESALE RESTRICTIONS PURSUANT TO THE PROVISIONS OF THE SECURITIES ACT (BRITISH COLUMBIA) (THE “SECURITIES ACT”) AND CERTAIN RESTRICTIONS UPON TRANSFER
PURSUANT TO THE TERMS HEREOF AND ANY SECURITIES FOR WHICH THIS WARRANT IS EXCHANGED ARE SUBJECT TO CERTAIN RESALE RESTRICTIONS PURSUANT TO THE SECURITIES ACT AND TO CERTAIN RESTRICTIONS UPON TRANSFER PURSUANT TO THE ARTICLES OF THE COMPANY. 

UNLESS PERMITTED UNDER APPLICABLE SECURITIES LEGISLATION, THE HOLDER OF THIS SECURITY MUST NOT TRADE THE SECURITY BEFORE THE DATE THAT IS 4
MONTHS AND A DAY AFTER THE LATER OF (i) AUGUST     , 2014 AND (ii) THE DATE THE COMPANY BECOMES A REPORTING ISSUER IN ANY PROVINCE OR TERRITORY IN CANADA. 

THIS WARRANT WILL BE VOID AND OF NO VALUE UNLESS EXERCISED WITHIN THE TIME LIMITS PROVIDED HEREIN. 

WARRANT TO PURCHASE COMMON SHARES 

Company: GENOMEDX BIOSCIENCES INC., a corporation organized under the laws of the Province of British Columbia (the
“Company”). 
 Number of Class A Common Shares of the Company (“Common Shares”): 43,757 (the
“Initial Shares”), plus all Additional Shares (as defined in Section 1.7) which Holder is entitled to purchase pursuant to Section 1.7 

Warrant Price: $1.3712 per share 

Issue Date: August 21, 2014 

Expiration Date: August 21, 2024 See also Section 5.1(b). 

 

	Credit Facility:	 This Warrant to Purchase Common Stock (“Warrant”) is issued in connection
with that certain Loan and Security Agreement of even date herewith between Silicon Valley Bank, the Company and GENOMEDX BIOSCIENCES CORP. (the “Loan Agreement”). 



THIS WARRANT CERTIFIES THAT, for good and valuable consideration, SILICON VALLEY BANK (together with any successor or
permitted assignee or transferee of this Warrant or of any shares issued upon exercise hereof, “Holder”) is entitled to purchase the 

  
 1 













 
number of fully paid and non-assessable Common Shares of the Company at the above-stated Warrant Price, all as set forth above and as adjusted pursuant to
Section 2 of this Warrant, subject to the provisions and upon the terms and conditions set forth in this Warrant. Reference is made to Section 5.4 of this Warrant whereby Silicon Valley Bank shall transfer this Warrant to its parent
company, SVB Financial Group. 
 SECTION 1. EXERCISE. 

1.1    Method of Exercise. Holder may at any time and from time to time exercise this Warrant, in
whole or in part, by delivering to the Company the original of this Warrant together with a duly executed Notice of Exercise in substantially the form attached hereto as Appendix 1 and, unless Holder is exercising this Warrant pursuant to a cashless
exercise set forth in Section 1.2, a check, wire transfer of same-day funds (to an account designated by the Company), or other form of payment acceptable to the Company for the aggregate Warrant Price
for the Common Shares being purchased. 
 1.2    Cashless Exercise. On any exercise of this
Warrant, in lieu of payment of the aggregate Warrant Price in the manner as specified in Section 1.1 above, but otherwise in accordance with the requirements of Section 1.1, Holder may elect to receive Common Shares equal to the value of
this Warrant, or portion hereof as to which this Warrant is being exercised. Thereupon, the Company shall issue to the Holder such number of fully paid and non-assessable Common Shares as are computed using
the following formula: 
  

					
		 	 X = Y(A-B)/A

	 where:
	 		 	
			
		 	 X =
	 	 the number of Common Shares to be issued to the Holder;

			
		 	 Y =
	 	 the number of Common Shares with respect to which this Warrant is being exercised (inclusive of the Common Shares
surrendered to the Company in payment of the aggregate Warrant Price);

			
		 	 A =
	 	 the Fair Market Value (as determined pursuant to Section 1.3 below) of one Share; and

			
		 	 B =
	 	 the Warrant Price.


 1.3    Fair Market Value. If the Company’s Common Shares are
then traded or quoted on a nationally recognized securities exchange, inter-dealer quotation system or over-the-counter market (a “Trading
Market”), the fair market value of a Common Share shall be the closing price or last sale price of a share of Common Share reported for the Business Day immediately before the date on which Holder delivers this Warrant together with its
Notice of Exercise to the Company. If the Company’s Common Shares are not traded in a Trading Market, the Board of Directors of the Company shall determine the fair market value of a Common Share in its reasonable good faith judgment. 

  
 2 













 1.4    Delivery of Certificate and New Warrant.
Within a reasonable time after Holder exercises this Warrant in the manner set forth in Section 1.1 or 1.2 above, the Company shall deliver to Holder a certificate representing the Common Shares issued to Holder upon such exercise and, if this
Warrant has not been fully exercised and has not expired, a new warrant of like tenor representing the Common Shares not so acquired. 

1.5    Replacement of Warrant. On receipt of evidence reasonably satisfactory to the Company of the
loss, theft, destruction or mutilation of this Warrant and, in the case of loss, theft or destruction, on delivery of an indemnity agreement reasonably satisfactory in form, substance and amount to the Company or, in the case of mutilation, on
surrender of this Warrant to the Company for cancellation, the Company shall, within a reasonable time, execute and deliver to Holder, in lieu of this Warrant, a new warrant of like tenor and amount, taking into account all prior exercises and
adjustments. 
 1.6    Treatment of Warrant Upon Acquisition of Company. 

(a)    Acquisition. For the purpose of this Warrant, “Acquisition” means any
transaction or series of related transactions involving: (i) the sale, lease, exclusive license, or other disposition of all or substantially all of the assets of the Company (ii) any merger or consolidation of the Company into or with
another person or entity (other than a merger or consolidation effected exclusively to change the Company’s domicile), or any other corporate reorganization, in which the stockholders of the Company in their capacity as such immediately prior
to such merger, consolidation or reorganization, own less than a majority of the Company’s (or the surviving or successor entity’s) outstanding voting power immediately after such merger, consolidation or reorganization; or (iii) any
sale or other transfer by the stockholders of the Company of shares representing at least a majority of the Company’s then-total outstanding combined voting power. 

(b)    Treatment of Warrant at Acquisition. In the event of an Acquisition in which the
consideration to be received by the Company’s shareholders consists solely of cash, solely of Marketable Securities or a combination of cash and Marketable Securities (a “Cash/Public Acquisition”), and the fair market
value of one Common Share as determined in accordance with Section 1.3 above would be greater than the Warrant Price in effect on such date immediately prior to such Cash/Public Acquisition, and Holder has not exercised this Warrant pursuant to
Section 1.1 above as to all Common Shares, then this Warrant shall automatically be deemed to be Cashless Exercised pursuant to Section 1.2 above as to all Common Shares effective immediately prior to and contingent upon the consummation
of a Cash/Public Acquisition. In connection with such Cashless Exercise, Holder shall be deemed to have restated each of the representations and warranties in Section 4 of the Warrant as the date thereof and the Company shall promptly notify
the Holder of the number of Common Shares (or such other securities) issued upon exercise. In the event of a Cash/Public Acquisition where the fair market value of one Common Share as determined in accordance with Section 1.3 above would be
less than the Warrant Price in effect immediately prior to such Cash/Public Acquisition, then this Warrant will expire immediately prior to the consummation of such Cash/Public Acquisition. 

(c)    Upon the closing of any Acquisition other than a Cash/Public Acquisition defined above, the
acquiring, surviving or successor entity shall assume the obligations of this 

  
 3 













 
Warrant, and this Warrant shall thereafter be exercisable for the same securities and/or other property as would have been paid for the Common Shares issuable upon exercise of the unexercised
portion of this Warrant as if such Common Shares were outstanding on and as of the closing of such Acquisition, subject to further adjustment from time to time in accordance with the provisions of this Warrant. 

(d)    As used in this Warrant, “Marketable Securities” means securities meeting
all of the following requirements: (i) the issuer thereof is then subject to the reporting requirements of Section 13 or Section 15(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or
similar reporting requirements of applicable securities laws in Canada, and is then current in its filing of all required reports and other information under the Act and the Exchange Act or under such applicable securities laws in Canada;
(ii) the class and series of shares or other security of the issuer that would be received by Holder in connection with the Acquisition were Holder to exercise this Warrant on or prior to the closing thereof is then traded in Trading Market,
and (iii) if such Trading Market is a Canada Trading Market, following the closing of such Acquisition, Holder would not be restricted from publicly re-selling all of the issuer’s shares and/or other
securities that would be received by Holder in such Acquisition were Holder to exercise or convert this Warrant in full on or prior to the closing of such Acquisition, or if such Trading Market is a US Trading Market, Holder would be able to
publicly re sell all of the issuer’s shares and/or other securities that would be received by Holder in such Acquisition were Holder to exercise this Warrant in full on or prior to the closing of such Acquisition, except to the extent that any
such restriction (x) arises solely under federal or state securities laws, rules or regulations, and (y) does not extend beyond six (6) months from the closing of such Acquisition. 

1.7    Number of Common Shares. This Warrant shall be exercisable for the Initial Shares, plus,
upon Silicon Valley Bank making the first Tranche B Growth Capital Advance (as defined in the Loan Agreement) to the Company pursuant to the Loan Agreement, the Additional Shares. As used herein, “Additional Shares” means Forty-Three
Thousand Seven Hundred Fifty-Seven (43,757) Common Shares. 
 SECTION 2. ADJUSTMENTS TO THE COMMON SHARES AND WARRANT PRICE. 

2.1    Share Dividends, Splits, Combinations, Etc. If the Company declares or pays a dividend or
distribution on the outstanding Common Shares payable in securities or property (other than cash), then upon exercise of this Warrant, for each Common Share acquired, Holder shall receive, without additional cost to Holder, the total number and kind
of securities and property which Holder would have received had Holder owned the Common Shares of record as of the date the dividend or distribution occurred. If the Company subdivides the outstanding Common Shares by reclassification or otherwise
into a greater number of shares, the number of Common Shares purchasable hereunder shall be proportionately increased and the Warrant Price shall be proportionately decreased. If the Company combines the outstanding Common Shares by reclassification
or otherwise, into a lesser number of shares, the Warrant Price shall be proportionately increased and the number of Common Shares into which this Warrant is exercisable shall be proportionately decreased. 

  
 4 













 2.2    Reclassification, Exchange or
Substitution. Upon any event whereby all of the outstanding Common Shares are reclassified, exchanged, substituted, or replaced for, into, with or by Company securities of a different class and/or series, then from and after the consummation of
such event, this Warrant will be exercisable for the number, class and series of Company securities that Holder would have received had the Common Shares into which this Warrant is exercisable been outstanding on and as of the consummation of such
event, and subject to further adjustment thereafter from time to time in accordance with the provisions of this Warrant. The provisions of this Section 2.2 shall similarly apply to successive reclassifications, exchanges, combinations
substitutions, replacements or other similar events. 
 2.3    No Fractional Share. No fractional
Common Share shall be issuable upon exercise of this Warrant and the number of Common Shares to be issued shall be rounded down to the nearest whole Share. If a fractional Common Share interest arises upon any exercise of the Warrant, the Company
shall eliminate such fractional Common Share interest by paying Holder in cash the amount computed by multiplying the fractional interest by (i) the fair market value (as determined in accordance with Section 1.3 above) of a full Common
Share, less (ii) the then-effective Warrant Price. 
 2.4    Notice/Certificate as to
Adjustments. Upon each adjustment of the Warrant Price, Common Stock and/or the number of Common Shares into which this Warrant is exercisable, the Company, at the Company’s expense, shall notify Holder in writing within a reasonable time
setting forth the adjustments to the Warrant Price, class and/or number of Common Shares into which this Warrant is exercisable and facts upon which such adjustment is based. The Company shall, upon written request from Holder, furnish Holder with a
certificate of its Chief Financial Officer, including computations of such adjustment and the Warrant Price, class and number of Common Shares (or other securities of the Company, to the extent applicable) into which this Warrant is exercisable in
effect upon the date of such adjustment. 
 SECTION 3. REPRESENTATIONS AND COVENANTS OF THE COMPANY. 

3.1    Representations and Warranties. The Company represents and warrants to, and agrees with, the
Holder as follows: 
 (a)    The initial Warrant Price referenced on the first page of this Warrant is
not greater than the fair market value of the Class B Preferred Shares of the Company as of the Issue Date. 

(b)    All Common Shares which may be issued upon the exercise of this Warrant, shall, upon issuance, be
duly authorized, validly issued, fully paid and non-assessable, and free of any liens and encumbrances except for restrictions on transfer provided for herein or under applicable US and Canada federal,
provincial and state securities laws. The Company covenants that it shall at all times cause to be reserved and kept available out of its authorized and unissued capital stock such number of securities as will be sufficient to permit the exercise in
full of this Warrant. 
 (c)    The Company’s capitalization table attached hereto as Schedule 1 is
true and complete, in all material respects, as of the Issue Date. 

  
 5 













 3.2    Notice of Certain Events. If the Company
proposes at any time to: 
 (a)    declare any dividend or distribution upon the outstanding Common
Shares, whether in cash, property, stock, or other securities and whether or not a regular cash dividend; 

(b)    offer for subscription or sale pro rata to the holders of the outstanding Common Shares any
additional shares of any class or series of the Company’s stock (other than pursuant to contractual pre-emptive rights); 

(c)    effect any reclassification, exchange, combination, substitution, reorganization or
recapitalization of the outstanding Common Shares; 
 (d)    effect an Acquisition or to liquidate,
dissolve or wind up; or 
 (e)    effect an its initial, underwritten offering and sale of its
securities to the public pursuant to an effective registration statement under the Act (the “IPO”); 
 then, in connection with
each such event, the Company shall give Holder: 
 (1)    in the case of the matters
referred to in (a) and (b) above, at least seven (7) Business Days prior written notice of the earlier to occur of the effective date thereof or the date on which a record will be taken for such dividend, distribution, or subscription
rights (and specifying the date on which the holders of outstanding Common Shares will be entitled thereto) or for determining rights to vote, if any, 

(2)    in the case of the matters referred to in (c) and (d) above at least seven
(7) Business Days prior written notice of the date when the same will take place (and specifying the date on which the holders of outstanding shares of the class will be entitled to exchange their shares for the securities or other property
deliverable upon the occurrence of such event and such reasonable information as Holder may reasonably require regarding the treatment of this Warrant in connection with such event giving rise to the notice); and 

(3)    with respect to the IPO, at least seven (7) Business Days prior written notice
of the date on which the Company proposes to file its registration statement or prospectus, as applicable, in connection therewith. 

Company will also provide information requested by Holder that is reasonably necessary to enable Holder to comply with Holder’s
accounting or reporting requirements. 
 SECTION 4. REPRESENTATIONS, WARRANTIES OF THE HOLDER. 

The Holder represents and warrants to the Company as follows: 

4.1    Purchase for Own Account. This Warrant and the Common Shares to be acquired upon exercise of
this Warrant by Holder are being acquired for investment for Holder’s 

  
 6 













 
account, not as a nominee or agent, and not with a view to the public resale or distribution within the meaning of the Act and the applicable securities laws of Canada. Holder also represents
that it has not been formed for the specific purpose of acquiring this Warrant or the Common Shares. 

4.2    Disclosure of Information. Holder is aware of the Company’s business affairs and
financial condition and has received or has had full access to all the information it considers necessary or appropriate to make an informed investment decision with respect to the acquisition of this Warrant and its underlying securities. Holder
further has had an opportunity to ask questions and receive answers from the Company regarding the terms and conditions of the offering of this Warrant and its underlying securities and to obtain additional information (to the extent the Company
possessed such information or could acquire it without unreasonable effort or expense) necessary to verify any information furnished to Holder or to which Holder has access. 

4.3    Investment Experience. Holder understands that the purchase of this Warrant and its
underlying securities involves substantial risk. Holder has experience as an investor in securities of companies in the development stage and acknowledges that Holder can bear the economic risk of such Holder’s investment in this Warrant and
its underlying securities and has such knowledge and experience in financial or business matters that Holder is capable of evaluating the merits and risks of its investment in this Warrant and its underlying securities and/or has a preexisting
personal or business relationship with the Company and certain of its officers, directors or controlling persons of a nature and duration that enables Holder to be aware of the character, business acumen and financial circumstances of such persons.

 4.4    Accredited Investor Status. Holder is an “accredited investor” within the
meaning of Regulation D promulgated under the Act and National Instrument 45-106 Prospectus and Registration Exemptions and is purchasing the Warrant pursuant to an exemption from the prospectus
requirements of applicable securities laws. Holder has executed and delivered as principal the Accredited Investor Certificate as set forth in the Loan Agreement. 

4.5    The Act. Holder understands that this Warrant and the Common Shares issuable upon exercise
hereof have not been registered under the Act in reliance upon a specific exemption therefrom, which exemption depends upon, among other things, the bona fide nature of the Holder’s investment intent as expressed herein. Holder understands that
this Warrant and the Common Shares issued upon any exercise hereof must be held indefinitely unless subsequently registered under the Act pursuant to an effective registration statement or receipted final prospectus and qualified under applicable
state, provincial or territorial securities laws, or unless exemption from such registration and qualification are otherwise available. Holder is aware of the provisions of Rule 144 promulgated under the Act. 

4.6    Market Stand-off Agreement. The Holder agrees that
the Common Shares shall be subject to the market standoff provisions in Section 2.11 of the Amended and Restated Investor Rights Agreement of the Company dated September 18, 2013. 

4.7    No Voting Rights. Holder, as a Holder of this Warrant, will not have any voting rights until
the exercise of this Warrant. 

  
 7 













 SECTION 5. MISCELLANEOUS. 

5.1    Term and Automatic Conversion Upon Expiration. 

(a)    Term. Subject to the provisions of Section 1.6 above, this Warrant is exercisable in whole or
in part at any time and from time to time on or before 6:00 PM, Pacific time, on the Expiration Date and shall be void thereafter. 

(b)    Automatic Cashless Exercise upon Expiration. In the event that, upon the Expiration Date, the fair
market value of one Share (or other security issuable upon the exercise hereof) as determined in accordance with Section 1.3 above is greater than the Warrant Price in effect on such date, then this Warrant shall automatically be deemed on and
as of such date to be exercised pursuant to Section 1.2 above as to all Common Shares (or such other securities) for which it shall not previously have been exercised, and the Company shall, within a reasonable time, deliver a certificate
representing the Common Shares (or such other securities) issued upon such exercise to Holder. 

5.2    Legends. The Common Shares (and the securities issuable, directly or indirectly, upon
conversion of the Common Shares, if any) shall be imprinted with a legend in substantially the following form: 
 THE COMMON
SHARES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN THAT CERTAIN WARRANT TO PURCHASE COMMON
STOCK ISSUED BY THE ISSUER TO SILICON VALLEY BANK DATED AUGUST     , 2014, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR IN FORM AND SUBSTANCE SATISFACTORY TO
THE ISSUER, SUCH OFFER, SALE, PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION. 
 THE COMMON SHARES REPRESENTED BY
THIS CERTIFICATE ARE SUBJECT TO CERTAIN RESALE RESTRICTIONS PURSUANT TO THE PROVISIONS OF THE SECURITIES ACT (BRITISH COLUMBIA) AND CERTAIN RESTRICTIONS UPON TRANSFER PURSUANT TO THE TERMS OF THE WARRANT AND PURSUANT TO THE ARTICLES OF THE COMPANY.

 UNLESS PERMITTED UNDER SECURITIES LEGISLATION, THE HOLDER OF THIS SECURITY MUST NOT TRADE THE SECURITY BEFORE THE DATE
THAT IS 4 MONTHS AND A DAY AFTER THE LATER OF (i) AUGUST     , 2014, AND (ii) THE DATE THE 

  
 8 













 
COMPANY BECOMES A REPORTING ISSUER IN ANY PROVINCE OR TERRITORY IN CANADA. 

DELIVERY OF THIS CERTIFICATE MAY NOT CONSTITUTE “GOOD DELIVERY” IN SETTLEMENT OF TRANSACTIONS ON STOCK EXCHANGES IN
CANADA. A NEW CERTIFICATE, BEARING NO LEGEND, DELIVERY OF WHICH WILL CONSTITUTE “GOOD DELIVERY”, MAY BE OBTAINED FROM THE COMPANY UPON DELIVERY OF THIS CERTIFICATE AND A DULY EXECUTED DECLARATION, IN FORM SATISFACTORY TO THE COMPANY, TO
THE EFFECT THAT THE SALE OF THE SECURITIES REPRESENTED HEREBY IS BEING MADE IN COMPLIANCE WITH RULE 904 OF REGULATIONS UNDER THE 1933 ACT, AS AMENDED. 

5.3    Compliance with Securities Laws on Transfer. This Warrant and the Common Shares issuable
upon exercise of this Warrant (and the securities issuable, directly or indirectly, upon conversion of the Common Shares, if any) may not be transferred or assigned in whole or in part except in compliance with applicable US and Canadian federal,
provincial and state securities laws by the transferor and the transferee (including, without limitation, the delivery of investment representation letters and legal opinions reasonably satisfactory to the Company, as reasonably requested by the
Company). The Company shall not require Holder to provide an opinion of counsel if the transfer is to SVB Financial Group (Silicon Valley Bank’s parent company) or any other affiliate of Holder, provided that any such transferee is an
“accredited investor” as defined in Regulation D promulgated under the Act and National Instrument 45 106 Prospectus and Registration Exemptions. Additionally, the Company shall also not require an opinion of counsel if there is no
material question as to the availability of Rule 144 promulgated under the Act. 
 5.4    Transfer
Procedure. After receipt by Silicon Valley Bank of the executed Warrant, Silicon Valley Bank will transfer all of this Warrant to its parent company, SVB Financial Group. By its acceptance of this Warrant, SVB Financial Group hereby makes to the
Company each of the representations and warranties set forth in Section 4 hereof and agrees to be bound by all of the terms and conditions of this Warrant as if the original Holder hereof. Subject to the provisions of Section 5.3 and upon
providing the Company with written notice, SVB Financial Group and any subsequent Holder may transfer all or part of this Warrant or the Common Shares issuable upon exercise of this Warrant (or the securities issuable directly or indirectly, upon
conversion of the Common Shares, if any) to any transferee, provided, however, in connection with any such transfer, SVB Financial Group or any subsequent Holder will give the Company notice of the portion of the Warrant being transferred with the
name, address and taxpayer identification number of the transferee and Holder will surrender this Warrant to the Company for reissuance to the transferee(s) (and Holder if applicable); and provided further, that any subsequent transferee other than
SVB Financial Group shall agree in writing with the Company to be bound by all of the terms and conditions of this Warrant. Notwithstanding any contrary provision herein, at all times prior to the IPO, Holder may not, without the Company’s
prior written consent, transfer this Warrant or any portion hereof, or any Common Shares issued 

  
 9 













 
upon any exercise hereof, or any shares or other securities issued upon any conversion of any Common Shares issued upon any exercise hereof, to any person or entity who directly competes with the
Company, except in connection with an Acquisition of the Company by such a direct competitor. 

5.5    Notices. All notices and other communications hereunder from the Company to the Holder, or
vice versa, shall be deemed delivered and effective (i) when given personally, (ii) on the third (3rd) Business Day after being mailed by first-class registered or certified mail, postage prepaid, (iii) upon actual receipt if given by
facsimile or electronic mail and such receipt is confirmed in writing by the recipient, or (iv) on the first Business Day following delivery to a reliable overnight courier service, courier fee prepaid, in any case at such address as may have
been furnished to the Company or Holder, as the case may be, in writing by the Company or such Holder from time to time in accordance with the provisions of this Section 5.5. All notices to Holder shall be addressed as follows until the Company
receives notice of a change of address in connection with a transfer or otherwise: 
 SVB Financial Group 

Attn: Treasury Department 

3003 Tasman Drive, HC 215 

Santa Clara, CA 95054 

Telephone: 

Facsimile: 

Email address: 

Notice to the Company shall be addressed as follows until Holder receives notice of a change in address: 

GenomeDx Biosciences Inc. 

#400-311 Water Street 

Vancouver, BC, V6B 1B8 

Attn: Dave Matthews - CFO 

Fax:       

Email: 

5.6    Waiver. This Warrant and any term hereof may be changed, waived, discharged or terminated
(either generally or in a particular instance and either retroactively or prospectively) only by an instrument in writing signed by the party against which enforcement of such change, waiver, discharge or termination is sought. 

5.7    Attorney’s Fees. In the event of any dispute between the parties concerning the terms
and provisions of this Warrant, the party prevailing in such dispute shall be entitled to collect from the other party all costs incurred in such dispute, including reasonable attorneys’ fees. 

5.8    Counterparts; Facsimile/Electronic Signatures. This Warrant may be executed in counterparts,
all of which together shall constitute one and the same agreement. Any signature page delivered electronically or by facsimile shall be binding to the same extent as an 

  
 10 













 
original signature page with regards to any agreement subject to the terms hereof or any amendment thereto. 

5.9    Governing Law. This Warrant shall be governed by and construed in accordance with the laws
of the Province of British Columbia and the laws of Canada applicable therein. 

5.10    Headings. The headings in this Warrant are for purposes of reference only and shall not
limit or otherwise affect the meaning of any provision of this Warrant. 
 5.11    Business Days.
“Business Day” is any day that is not a Saturday, Sunday or a day on which Silicon Valley Bank or banks in Vancouver, British Columbia are closed. 

[Remainder of page left blank intentionally] 

[Signature page follows] 

  
 11 













 IN WITNESS WHEREOF, the parties have caused this Warrant to Purchase Common
Stock to be executed by their duly authorized representatives effective as of the Issue Date written above. 
 “COMPANY” 

GENOMEDX BIOSCIENCES INC. 
  

			
	 By: 
	 	 /s/ David Matthews

	 Name:
	 	 David Matthews

		 	 (Print)

	 Title:
	 	 Chief Financial Officer & Secretary

	
	 “HOLDER”

	
	 SILICON VALLEY BANK

		
	 By: 
	 	 /s/ David Sanders

	 Name:
	 	 David Sanders

		 	 (Print)

	 Title:
	 	 VP














 APPENDIX 1 

NOTICE OF EXERCISE 

1.    The undersigned Holder hereby exercises its right to purchase
                 the Class A Common Shares of GENOMEDX BIOSCIENCES INC. (the “Company”) in accordance with the attached Warrant To
Purchase Common Shares, and tenders payment of the aggregate Warrant Price for such shares as follows: 
  

	 	☐	 check in the amount of $         payable to order of the
Company enclosed herewith 


  

	 	☐	 Wire transfer of immediately available funds to the Company’s account 



 

	 	☐	 Cashless Exercise pursuant to Section 1.2 of the Warrant 



 

	 	☐	 Other [Describe]
                     



2.    Please issue a certificate or certificates representing the Common Shares in the name specified
below: 
  

					
		 	  
	 	
		 	Holder’s Name (Address)	 	
			
		 	  
	 	
			
		 	  
	 	
		 	(Address)	 	

 3.    By its execution below and for the benefit of the Company, Holder
hereby restates each of the representations and warranties in Section 4 of the Warrant to Purchase Common Shares as of the date hereof. 
  

			
	 HOLDER:
	 	
	
	  

		
	 By:
	 	
                  
                                         
                     

		
	 Name:
	 	
                  
                                         
  

		
	 Title:
	 	
                  
                                         
  

		
	 (Date):
	 	
                  
                                         
                      















 SCHEDULE 1 

Company Capitalization Table 

See attached