*Note that agenda times are approximate. For further information, please contact the Designated Federal 

Officer for this meeting, Jim Downing via telephone: (202) 564-2468 or email: downing.jim@epa.gov

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

HUMAN STUDIES REVIEW BOARD (HSRB)

PUBLIC TELECONFERENCE MEETING

AGENDA

Wednesday, January 11, 2012

1:00 pm - 4:00 pm (Eastern Time)*

HSRB MEETING FOR REVIEW AND APPROVAL OF THE

DRAFT OCTOBER 19-20, 2011 HSRB MEETING REPORT

HSRB WEB SITE http://www.epa.gov/osa/hsrb/

Docket Telephone: (202) 566 1752

Docket Number: EPA–HQ–ORD–2011–0953

Meeting location via telephone only

Dial in number 866-299-3188; conference code 2025647189

1:00 PM Convene Meeting and Identification of Board Members – Jim Downing 

(Designated Federal Officer, EPA HSRB, OSA)

1:10 PM* Meeting Administrative Procedures – Jim Downing, DFO

1:15 PM Meeting Process – Sean Philpott, Ph.D. (HSRB Chair)

1:20 PM Public Comments

1:30 PM Board Discussion and Decision on Final Report – Sean Philpott, Ph.D. (HSRB 

Chair)

The Board’s response to EPA charge questions presented at the October 19-20, 2011 meeting.

A new scenario design and associated protocol from the Antimicrobial Exposure 

Assessment Task Force II (AEATF-II), describing proposed research to monitor the 

dermal and inhalation exposure of workers while pouring liquid antimicrobial pesticide 

products from both conventional and reduced-splash containers.

Charge to the Board:

If the AEATF liquid pour study proposal is revised as suggested in EPA’s review and if the 

research is performed as described:

 Is the research likely to generate scientifically reliable data, useful for assessing the 

exposure of individuals who manually pour liquid antimicrobial products?

 Is the research likely to meet the applicable requirements of 40 CFR part 26, subparts K 

and L?

A new scenario design and associated protocols from the Agricultural Handler Exposure 

Task Force (AHETF) describing proposed research to measure dermal and inhalation 
*Note that agenda times are approximate. For further information, please contact the Designated Federal 

Officer for this meeting, Jim Downing via telephone: (202) 564-2468 or email: downing.jim@epa.gov

exposure to workers who use closed system equipment to load liquid pesticide products 

from returnable and non-returnable containers.

Charge to the Board: 

If the AHETF closed system liquid loading study proposal is revised as suggested in EPA’s 

review and if the research is performed as described:

 Is the research likely to generate scientifically reliable data, useful for assessing the 

exposure of workers using closed systems to load liquid pesticide products from 

returnable or non-returnable containers?

 Is the research likely to meet the applicable requirements of 40 CFR part 26, subparts K 

and L?

A completed Carroll-Loye Biological Research, Inc. (CLBR) study (No Mas 003) to 

evaluate the field repellent efficacy against mosquitoes of a product containing 16% paramethane-3,8-diol and 2% lemongrass oil.

Charge to the Board: 

 Is the CLBR completed study No Mas 003 sufficiently sound, from a scientific 

perspective, to be used to estimate the duration of complete protection against mosquitoes 

provided by the tested repellent?

 Does available information support a determination that the study No Mas 003 was 

conducted in substantial compliance with 40 CFR Part 26, subparts K and L?

A published report by Moiemen et al (2011) of an intentional exposure human study 

measuring dermal absorption of silver from the use of nanosilver-containing wound 

dressings to treat major burns.

Charge to the Board: 

 Is the Moiemen (2011) study scientifically sound, providing reliable data? 

 If so, can the Moiemen (2011) study be used to support the Agency's conclusion 

that the dermal absorption factor for silver from nanosilver on human skin is less 

than 0.1%?

 Is there adequate information to support a determination that the study was 

conducted in substantial compliance procedures at least as protective as those at 

subparts A-L of 40 CFR Part 26?

3:55 PM Summary and Next Steps – Sean Philpott, Ph.D. (HSRB Chair) and Jim 

Downing (DFO)

4:00 PM Adjournment