Page 2 of 4 

(2,000) are all greater than the respective target MOEs, therefore the risks are not of concern on 

an individual basis. 

In the previous human health risk assessment, a short term aggregate risk of 3.1 for adults was 

determined as shown in Table 1 by aggregating the food and water exposures with the post 

application inhalation exposures from metered release devices. Because the MOE of 370 for 

post application inhalation exposures from metered release devices is less than the MOE of 

400,000 for application of pet sprays, the aggregate risk would not change as a result of the 

increased pet spray application rate, and, therefore, it is not necessary to recalculate the 

aggregate risk for adults. 

In the previous risk assessment, a short term aggregate risk of 0.96 for children was determined 

by aggregating the food and water exposures with the incidental oral exposure from playing on 

vinyl floors after fogger treatment and the inhalation exposures from the use of meter release 

devices. Because the incidental oral MOE of 2,000 for playing with treated pets is less than the 

incidental oral MOE of 6,900 for playing on vinyl floors, the aggregate risk is reduced to 0.82 as 

shown in bold text in Table 1. This risk is of concern because it is significantly less than 1.0. 

As discussed in the Pyrethrin RED of June 2006, the Pyrethrin Joint Venture agreed to remove 

the following use sites from their metered release product labels: day care centers, nursing 

homes, schools and hospitals. In addition, EPA is requiring air concentration and particle size 

data for indoor metered release devices and will prohibit metered release device use in residential 

areas unless data are submitted in a timely fashion. Given the above, the metered release 

scenario could be deleted from the aggregate risk calculation as shown in Table 2. The next 

highest inhalation exposure is from space sprays with short term MOEs of 2,100 for adults and 

640 for toddlers. The aggregate risks range from 1.8 for children to 10 for adult females and are 

not of concern because they are greater than 1.0. 
Page 3 of 4 

Table 1. Short-Term Aggregate Risk Calculations (Includes pet spray incidental oral exposure with rate increase)

Population 

Food + 

Water 

Exposure

Incidental 

Oral 

Exposure

Total 

Incidental 

Oral + Food 

+ Water 

Exposure

MOE 

Food + 

Water+ 

Incidental 

Oral

ARI 

Food + Water+ 

Incidental Oral1

MOE 

Inhalation

ARI 

Inhalatio

Adult Male 0.0037 0 0.0037 5405 18 370 3.7 Adult Female 0.0034 0 0.0034 5850 20 370 3.7 Child 0.011 0.010 0.026 770 2.6 120 1.2 Non-hisp/non-white/ nonblack (Highest Exposed Adult Subpop) 

0.0069 0 0.0069 2900 9.7 370 3.7 

1ARI = [MOECALCULATED ( i.e., FOOD, WATER, DERMAL, INHALATION, ORAL) ÷ MOEACCEPTABLE] (Note: Target ARI > 1) 2Aggregate ARI = 1__________ 

 1 + 1______ 

 ARIFOOD +WATER+ORAL ARIINHALATION

*Note – Values in bold are based on the incidental oral exposure from treated pets at the increased rate of 0.2 percent.
Page 4 of 4 

Table 2. Short-Term Aggregate Risk Calculations (Includes pet spray with rate increase and substitution of space spray inhalation exposure for metered release inhalation ex

Population 

Food + 

Water 

Exposure

Incidental 

Oral 

Exposure

Total 

Incidental 

Oral + Food 

+ Water 

Exposure

MOE 

Food + 

Water+ 

Incidental 

Oral

ARI 

Food + Water+ 

Incidental Oral1

MOE 

Inhalation

ARI 

Inhalatio

Adult Male 0.0037 0 0.0037 5405 18 2100 21 Adult Female 0.0034 0 0.0034 5850 20 2100 21 Child 0.011 0.010 0.026 770 2.6 640 6.4 Non-hisp/non-white/ nonblack (Highest Exposed Adult Subpop) 

0.0069 0 0.0069 2900 9.7 2100 21 

1ARI = [MOECALCULATED ( i.e., FOOD, WATER, DERMAL, INHALATION, ORAL) ÷ MOEACCEPTABLE] (Note: Target ARI > 1) 2Aggregate ARI = 1__________ 

 1 + 1______ 

 ARIFOOD +WATER+ORAL ARIINHALATION

*Note – Values in bold are based on the incidental oral exposure from treated pets and inhalation exposure from space sprays.