# Support Documents for Significant New Use Rule (SNUR) on Premanufacture Notice (PMN) P-12-332

EPA Docket EPA-HQ-OPPT-2012-0740

# Index A-001 Structure Activity Team (SAT) Report for PMN P-12-332 A-002 Initial Review Engineering Report for PMN P-12-332 A-003 Initial Review Exposure Report for PMN P-12-332

# A-001 Structure Activity Team (SAT) Report for PMN P-12-332

## SAT Report PMN Number: P-12-0332 SAT Date: 5/11/2012 Print Date: 5/31/2012
Related cases : Health related cases: Ecotox related cases: N o suitable analogs found
Concern levels : 

### Type of Concern: Health Eco Comments Level of Concern: 1-2 1

Persistence Bioaccum Toxicity Comments 2 21

Exposure Based Review : Health: N o Ecotox: N o Routes of exposure : Health: Dermal Inhalation Ecotox: N o releases to water Fate: ; Keywords : Keywords: LIVER Summary of Assessment : Fate : Fate Summary: P-12-0332 FATE: Estimations for low weight MW 261 Liquid with MP < 25 C (E) log Kow = 5.01 (E) S = 3.03 mg/L at 25 C (E) VP = 5.7E-4 torr at 25 C (E) BP = 323 C (E) H = 7.34E-5 (E) log Koc = 4.44 (E) log Fish BCF = 2.97 (E) log Fish BAF = 2.20 (E)

### POTW removal (%) = 90 via sorption and possible partial biodeg Time for complete ultimate aerobic biodeg = wk - > mo Sorption to soils/sediments = v.strong Volatilization half-life from a standard river = 24 hrs Volatilization half-life from a standard lake = 12 da Atmospheric Oxidation Half-life = 16 hr via OH radical PBT Potential: P2B2 *CEB FATE: Migration to ground water = negl
Health : Health Summary: Absorption of lower molecular weight portions is expected to be poor all routes ( p che m ). Concern for liver toxicity.
Ecotox : Test Organism Test Type Test End Point Predicted Measured Comments
fish 96-h LC50 * daphnid 48-h LC50 * green algal 96-h EC50 * fish

_ chronic value * daphnid

_ chronic value * algal

_ chronic value * Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value _
Ecotox Values Comments: Predictions are based on SARs for neutral organic chemicals; SAR chemical class = ; MW 444; log Kow = 8.03 (EPI); liquid with mp unknown (P); p H7; effective concentrations based on 100% active ingredients and nominal concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;
Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) *
SARs neutral organic chemicals SAR Class Ecotox Category N eutral Organics
Ecotox Factors Comments: SAT Chair: L Keifer 564-8916

# A-002 Initial Review Engineering Report for PMN P-12-332

### INITIAL REVIEW ENGINEERING REPORT PMN: 12-0332 , 0333 Focus Ready Draft 5/21/2012 ENGINEER: Austin \ BCS PV (kg/yr): X

SUBMITTER:
USE:

OTHER USES: None found.
MSDS: Label:
TLV/PEL: No MSDS Provided.

CRSS :

Consumer Use: No SAT (concerns) (05/11/2012): Related Cases and Related Cases and Misc SAT Info:

### No suitable analogs found. Migration to groundwater: Negligible PBT rating: P2B2T1 . Health: 1-2 Dermal, Inhalation Eco: 1 No releases to Water
OCCUPATIONAL EXPOSURE RATING: 1A
NOTES & KEY ASSUMPTIONS: Generated by the 06/07/2005 version of ChemSTEER.

POLLUTION PREVENTION CONSIDERATIONS: None.

EXPOSURE-BASED REVIEW:

### INITIAL REVIEW ENGINEERING REPORT PMN: 12-0332 , 0333

Number of Sites/ Location:

Days/yr: Basis:

Process Description:

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources to the same medium.

RELEASE TOTAL

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY Tot. # of workers exposed via assessed routes: Basis:
Inhalation:

### Dermal:

INITIAL REVIEW ENGINEERING REPORT PMN: 12-0332 , 0333

Number of Sites/ Location:

Days/yr: Basis:

Process Description

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources to the same medium.

### RELEASE TOTAL

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY Tot. # of workers exposed via assessed routes: Basis:

Inhalation:

Dermal:

MEMORANDUM of CBI TELEPHONE CONVERSATION
CALL BY:

CALL TO: Organization:
Date: 05/14/2012

### Time: 1:45pm
Phone: Concerning what TSCA CBI?
PMN: 12-0332

# A-003 Initial Review Exposure Report for PMN P-12-3325/18/2012 Page 1 of 13



### INITIAL REVIEW EXPOSURE REPORT (IRExR)
Chemical ID: P-12-0332 Reviewer: Tobais/SD

Results Table: Dose, Concentration, and Days Exceeded Results Summary

Exposure Scenario 1 Water Landfill Stack Air Fugitive Air
Drinking Water Fish Ingestion ADR LADD ADR LADD 7Q10 4 CC = 1000 PDM Days Exceede d LADD ADR LADD ADR LADD

Release activity(ies) 2 ; exposure calculation(s) 3 mg/kg/day m g/kg/day mg/kg/day mg/kg/day μg/l # Days mg/kg/day m g/kg/day mg/kg/day mg/kg/day mg/kg/day

Max ADR --- --- --- --- --- --- --- 1.08E+01 --- --- ---

Max LADD --- --- --- --- --- --- --- --- 2.40E-01 --- ---

Max ADR --- --- --- --- --- --- --- 1.07E+01 --- --- ---

Max LADD --- --- --- --- --- --- --- --- 2.40E-01 --- ---
1 Exposure scenario titles consist of release activity followed by exposure calculation abbreviation. 2 Release activities are from engineering report's Manufact uring (Mfg), Processing (Proc) and Use release activity labels. Multiple release activities are combined in one exposu re scenario if their releases occur at same location. 3 Exposure calculations are Acute Dose Rate (ADR), Lifetime Average Daily Dose (LADD), and Probabilistic Dilution Model (PDM). There may be one, two, or all th ree exposure calculations per exposure scenario. CC is the aquatic concentration of concern. 4 This column displays concentration values for the 7Q10 streamflow, which is defined as the average daily streamflow of the seven consecutive days of lowest flow within a ten year period.
Remarks: 

### Results Table: Exposure Based (X B)/Persistent (P2B2) Criteria

Parameter Exp Based Persistent Exceedance Value Drinking (Surface) Wate r Dose (mg/kg/day) No No Fish Ingestion Dose (mg/kg/day) No No Inhalation Dose (mg/kg/day) Yes Yes 2.40E-01 Groundwater Dose (mg/kg/day) No No Surface Water Release After Treatment (kg/yr) No No Total Release After Treatment (kg/yr) Consumer Use? No 

### Fate test recommendations?: (default is NA)5/18/2012 Page 2 of 13

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P-12-0332 Assessor: Tobais/SD
ENVIRONMENTAL RELEASES Scenario#:1 Number of Release Sites: Release Activity: Max ADR Release Description: WATER LANDFILL Non-sludge/Sludge STACK FUGITIVE

Total Releases: (k g/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge Release Days/yr: Per Site Release: (kg /site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:5/18/2012 Page 3 of 13

INITIAL REVIEW EX POSURE REPORT Chemical ID: P-12-0332
INHALATION EXPOSURE ESTIMATES (POST-TREATMENT)
SCENARIO #: 1 RELEASE ACTIVITY: Max ADR RELEASE DESCRIPTION: METHOD OF CALCULATION: Screen3 EXPOSED POPULATION: Adult

Number of Sites: Per Site Fugitive Release: kg/site/day Fugitive Release Days per Year: days % Removal via Fugitive Release: % Total Fugitive Release: kg/yr Max Annual Average Air Concentration (Fugitive): 0.00 μg/ m 3

Max 24 Hour Average Air Concentration(Fugitive): 0.00 μg/ m 3

Per Site Stack Release: kg/site/day Stack Release Days per Year: days % Removal via Stack Release: % Total Stack Release: kg/yr Max Annual Average Air Concen tration (Stack): 32.20 μg/m 3 Max 24 Hour Average Air Concentration (Stack): 5.87E+04 μg/m 3

ASSUMPTIONS Exposure Units Results (Stack) Results (Fugitive) ED (years) AT (years) BW (kg) Inh. Rate (m 3 /hr) Cancer LADD pot (mg/kg/day) 2.37E-03 N/A 30.00 75.00 71.80 0.55 LADC pot (mg/m 3 ) 1.29E-02 N/ A 30.00 75.00 NA NA Acute ADR pot

(mg/kg/day) 10.80 N/A NA 1 day 71.80 0.55

Inhalation Comments:5/18/2012 Page 4 of 13

Stack Parameter Data Fugitive Parameter Data Stack Height 10.00 m Release Height: N/A Inside Stack Diameter: 0.10 m Length of Release Opening: N/A

Stack Gas Exit Velocity: 0.10 m /sec Width of Release Opening: N/A

Stack Gas Temperature: 293.00 K

Meteorological and Terrain Information: Surrounding Land Use: Rural Terrain Height: 0.00 m Distance to Residence of Interest: 100.00 m Meteorological Class: Full Stability Class: NA Wind Speed: NA

Do wnwash Information: Facility Length: NA m Facility Width: NA m Facility Height: NA m5/18/2012 Page 5 of 13

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P-12-0332 Assessor: Tobais/SD
ENVIRONMENTAL RELEASES Scenario#:2 Number of Release Sites: Release Activity: Max LADD Release Description: WATER LANDFILL Non-sludge/Sludge STACK FUGITIVE

Total Releases: (k g/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge Release Days/yr: Per Site Release: (kg /site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:5/18/2012 Page 6 of 13

INITIAL REVIEW EX POSURE REPORT Chemical ID: P-12-0332
INHALATION EXPOSURE ESTIMATES (POST-TREATMENT)
SCENARIO #: 2 RELEASE ACTI VITY: Max LADD RELEASE DESCRIPTION: METHOD OF CALCULATION: Screen3 EXPOSED POPULATION: Adult

Number of Sites: Per Site Fugitive Release: kg/site/day Fugitive Release Days per Year: days % Removal via Fugitive Release: % Total Fugitive Release: kg/yr Max Annual Average Air Concentration (Fugitive): 0.00 μg/ m 3

Max 24 Hour Average Air Concentration(Fugitive): N/A μg/m 3

Per Site Stack Release: kg/site/day Stack Release Days per Year: days % Removal via Stack Release: % Total Stack Release: kg/yr Max Annual Average Air Concen tration (Stack): 3330.00 μg/m 3 Max 24 Hour Average Air Concentration (Stack): N/A μg/m 3

ASSUMPTIONS Exposure Units Results (Stack) Results (Fugitive) ED (years) AT (years) BW (kg) Inh. Rate (m 3 /hr) Cancer LADD pot (mg/kg/day) 0.24 N/A 30.00 75.00 71.80 0.55 LADC pot (mg/m 3 ) 1.33 N/ A 30.00 75.00 NA NA Acute ADR pot

(mg/kg/day) N/A N/A NA 1 day 71.80 0.55

Inhalation Comments:5/18/2012 Page 7 of 13

Stack Parameter Data Fugitive Parameter Data Stack Height 10.00 m Release Height: N/A Inside Stack Diameter: 0.10 m Length of Release Opening: N/A

Stack Gas Exit Velocity: 0.10 m /sec Width of Release Opening: N/A

Stack Gas Temperature: 293.00 K

Meteorological and Terrain Information: Surrounding Land Use: Rural Terrain Height: 0.00 m Distance to Residence of Interest: 100.00 m Meteorological Class: Full Stability Class: NA Wind Speed: NA

Do wnwash Information: Facility Length: NA m Facility Width: NA m Facility Height: NA m5/18/2012 Page 8 of 13

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P-12-0332 Assessor: Tobais/SD
ENVIRONMENTAL RELEASES Scenario#:3 Number of Release Sites: Release Activity: Max ADR Release Description: WATER LANDFILL Non-sludge/Sludge STACK FUGITIVE

Total Releases: (k g/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge Release Days/yr: Per Site Release: (kg /site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:5/18/2012 Page 9 of 13

INITIAL REVIEW EX POSURE REPORT Chemical ID: P-12-0332
INHALATION EXPOSURE ESTIMATES (POST-TREATMENT)
SCENARIO #: 3 RELEASE ACTIVITY: Max ADR RELEASE DESCRIPTION: METHOD OF CALCULATION: Screen3 EXPOSED POPULATION: Adult

Number of Sites: Per Site Fugitive Release: kg/site/day Fugitive Release Days per Year: days % Removal via Fugitive Release: % Total Fugitive Release: kg/yr Max Annual Average Air Concentration (Fugitive): 0.00 μg/ m 3

Max 24 Hour Average Air Concentration(Fugitive): 0.00 μg/ m 3

Per Site Stack Release: kg/site/day Stack Release Days per Year: days % Removal via Stack Release: % Total Stack Release: kg/yr Max Annual Average Air Concen tration (Stack): 31.80 μg/m 3 Max 24 Hour Average Air Concentration (Stack): 5.80E+04 μg/m 3

ASSUMPTIONS Exposure Units Results (Stack) Results (Fugitive) ED (years) AT (years) BW (kg) Inh. Rate (m 3 /hr) Cancer LADD pot (mg/kg/day) 2.34E-03 N/A 30.00 75.00 71.80 0.55 LADC pot (mg/m 3 ) 1.27E-02 N/ A 30.00 75.00 NA NA Acute ADR pot

(mg/kg/day) 10.67 N/A NA 1 day 71.80 0.55

Inhalation Comments:5/18/2012 Page 10 of 13

Stack Parameter Data Fugitive Parameter Data Stack Height 10.00 m Release Height: N/A Inside Stack Diameter: 0.10 m Length of Release Opening: N/A

Stack Gas Exit Velocity: 0.10 m /sec Width of Release Opening: N/A

Stack Gas Temperature: 293.00 K

Meteorological and Terrain Information: Surrounding Land Use: Rural Terrain Height: 0.00 m Distance to Residence of Interest: 100.00 m Meteorological Class: Full Stability Class: NA Wind Speed: NA

Do wnwash Information: Facility Length: NA m Facility Width: NA m Facility Height: NA m5/18/2012 Page 11 of 13

INITIAL REVIEW EXPOSURE REPORT

Chemical ID: P-12-0332 Assessor: Tobais/SD
ENVIRONMENTAL RELEASES Scenario#:4 Number of Release Sites: Release Activity: Max LADD Release Description: WATER LANDFILL Non-sludge/Sludge STACK FUGITIVE

Total Releases: (k g/yr) (kg/yr) (kg/yr) (kg/yr)

Non-sludge/Sludge Release Days/yr: Per Site Release: (kg /site/day) (kg/site/day) (kg/site/day) (kg/site/day)

Remarks:5/18/2012 Page 12 of 13

INITIAL REVIEW EX POSURE REPORT Chemical ID: P-12-0332
INHALATION EXPOSURE ESTIMATES (POST-TREATMENT)
SCENARIO #: 4 RELEASE ACTIVITY: Max LADD RELEASE DESCRIPTION: METHOD OF CALCULATION: Screen3 EXPOSED POPULATION: Adult

Number of Sites: Per Site Fugitive Release: kg/site/day Fugitive Release Days per Year: days % Removal via Fugitive Release: % Total Fugitive Release: kg/yr Max Annual Average Air Concentration (Fugitive): 0.00 μg/ m 3

Max 24 Hour Average Air Concentration(Fugitive): N/A μg/m 3

Per Site Stack Release: kg/site/day Stack Release Days per Year: days % Removal via Stack Release: % Total Stack Release: kg/yr Max Annual Average Air Concen tration (Stack): 3330.00 μg/m 3 Max 24 Hour Average Air Concentration (Stack): N/A μg/m 3

ASSUMPTIONS Exposure Units Results (Stack) Results (Fugitive) ED (years) AT (years) BW (kg) Inh. Rate (m 3 /hr) Cancer LADD pot (mg/kg/day) 0.24 N/A 30.00 75.00 71.80 0.55 LADC pot (mg/m 3 ) 1.33 N/ A 30.00 75.00 NA NA Acute ADR pot

(mg/kg/day) N/A N/A NA 1 day 71.80 0.55

Inhalation Comments:5/18/2012 Page 13 of 13

Stack Parameter Data Fugitive Parameter Data Stack Height 10.00 m Release Height: N/A Inside Stack Diameter: 0.10 m Length of Release Opening: N/A

Stack Gas Exit Velocity: 0.10 m /sec Width of Release Opening: N/A

Stack Gas Temperature: 293.00 K

Meteorological and Terrain Information: Surrounding Land Use: Rural Terrain Height: 0.00 m Distance to Residence of Interest: 100.00 m Meteorological Class: Full Stability Class: NA Wind Speed: NA

Do wnwash Information: Facility Length: NA m Facility Width: NA m Facility Height: NA m