EXHIBIT E

Case 2:21-cv-00640-RJS Document 2-5 Filed 10/28/21 PageID.31 Page 1 of 4
March 24, 2021 10:15 AM Eastern Daylight Time

WASHINGTON--(BUSINESS WIRE)--Xlear has filed a Pre-Emergency Use Authorization (Pre-EUA) Request with the U.S.

Food and Drug Administration (FDA) seeking approval to make claims that the nasal spray is approved for use in

preventing SARS-CoV-2 (COVID-19) transmission and infection. The Pre-EUA is a first step in seeking formal

authorization of Xlear Nasal Spray as tool to help in combatting COVID-19.

Xlear previously filed a pre-EUA seeking approval for use of the nasal spray as a medical device in combatting COVID-19.

However, because the FDA determined that Xlear “works against the virus,” the FDA told Xlear it would need to be

considered as a drug or combination product EUA.

“Seeing that the FDA says Xlear works against the virus, we have decided to seek EUA approval as a drug,” said Nathan

Jones, Xlear’s CEO.

Xlear’s Pre-EUA Request is based on recent studies showing the nasal spray is:

virucidal (it kills the virus);

antiviral (it blocks the adhesion of the virus to the nasal membrane, which is how most

people get sick from COVID-19);

antibacterial against streptococcus bacteria, which is the leading cause of bacterial

pneumonia (a COVID-19 complication linked to morbidity); and,

Reduces both the duration and severity of illness when used to treat COVID-19 patients.

Xlear is currently sold in over 50,000 pharmacies, grocery stores, and online as a nasal spray. “Xlear doesn’t require the

EUA to be sold and used—we only need an EUA to be able to inform people about the benefits of using Xlear to protect

themselves from COVID-19. It’s insane. Without the EUA, the Federal Trade Commission won’t let us simply inform people

about new, published, independent scientific studies,” Jones added.

“We hope to move forward quickly with FDA to address gaps in current prevention and treatment strategies against SARSCoV-2. People should be using Xlear as part of a layered defense to prevent getting COVID-19. If everyone used Xlear, in

addition to taking other steps recommended by public health officials, we believe we could help the nation defeat COVID19 faster,” Jones added.

Xlear Submits COVID-19 Pre-Emergency Use Authorization Request

with FDA Regarding Use of Xlear Nasal Spray in Help in Combating

SARS-CoV-2

Case 2:21-cv-00640-RJS Document 2-5 Filed 10/28/21 PageID.32 Page 2 of 4
More information on Xlear: https://xlear.com/

Contacts

Jeff Gulko

617.304.7339

jeff@thegulkogroup.com

Tweets by @XlearInc

Aug 16, 2021

To work properly, the nose needs to be hydrated with the mucus thinned to a point that it can

easily flow. 

Xlear pulls moisture into the nose, which hydrates the sinus cavity and thins the mucus,

assisting the body in its natural defenses to rid it of contaminants. 

 

That feeling of breathing clearly? We'll raise a Xlear bottle to that. #BreatheBetter

#LiveXlear

 

Xlear

@XlearInc

Xlear

@XlearInc

Case 2:21-cv-00640-RJS Document 2-5 Filed 10/28/21 PageID.33 Page 3 of 4
Aug 13, 2021

Xlear Retweeted

Very excited to announce a new formula based on new research! 

businesswire.com/news/home/2021...

 

Spry Dental Defense System

@SprySmile

#Hashtags

Social Media Profiles

#health #virucidal #eua #fda #antiviral #antibacterial #xylitol #xlear

#xlearinc #COVID19 #natejones #nasalspray #prevention #covid

Xlear/Facebook

Xlear/Twitter

Xlear/Instagram

Case 2:21-cv-00640-RJS Document 2-5 Filed 10/28/21 PageID.34 Page 4 of 4