<PAGE>









                                LICENSE AGREEMENT

                                     between

                             SMITHKLINE BEECHAM PLC

                                       and

                        PACIFIC HEALTH LABORATORIES INC.








<PAGE>


              [Portions of this Exhibit have been omitted pursuant
               ---------------------------------------------------
                    to a Request for Confidential Treatment]
                    ---------------------------------------

THE SYMBOL "[*]" IS USED TO INDICATE WHERE A PORTION OF THIS EXHIBIT HAS BEEN
OMITTED. CONFIDENTIAL TREATMENT HAS BEEN REQUESTED WITH RESPECT TO THE OMITTED
PORTIONS. A COMPLETE COPY OF THIS EXHIBIT, CONTAINING ALL OF THE OMITTED
PORTIONS, HAS BEEN SEPARATELY FILED WITH THE SECURITIES AND EXCHANGE COMMISSION
TOGETHER WITH THE REQUEST FOR CONFIDENTIAL TREATMENT.


                                LICENSE AGREEMENT
                                -----------------

THIS LICENSE AGREEMENT (hereinafter "AGREEMENT"), made as of the ___ day of June
2001 between SMITHKLINE BEECHAM PLC (doing business as GlaxoSmithKline), a
corporation incorporated in England and Wales, having a principal place of
business at New Horizons Court, Brentford Middlesex, England and PACIFIC HEALTH
LABORATORIES INC., a corporation of the State of Delaware, having a principal
place of business at 1480 Route 9 North, Suite 204, Woodbridge, New Jersey
07095.

                                WITNESSETH THAT:
                                ----------------

         WHEREAS, PACIFIC, as defined below, is the owner of all right, title
and interest in certain patents, identified in Appendix A hereto, and know-how
relating to certain products in the field of appetite suppression, meal
replacement, weight loss and/or weight management under development and/or
marketed by PACIFIC under the brand name "Satietrol(R)"; and
         WHEREAS, GSK, as defined below, desires to obtain certain licenses from
PACIFIC to develop and commercialize such products under the aforesaid patents
and know-how, and PACIFIC is willing to grant to GSK such licenses;








                                                                          Page 2
<PAGE>

         NOW, THEREFORE, in consideration of the covenants and obligations
expressed herein, and intending to be legally bound, and otherwise to be bound
by proper and reasonable conduct, the parties agree as follows:

1.       DEFINITIONS
         -----------
         1.01  "AFFILIATES" shall mean any corporation, firm, partnership or
other entity, whether de jure or de facto, which directly or indirectly owns, is
owned by or is under common ownership with a party to this AGREEMENT to the
extent of at least fifty percent (50%) of the equity (or such lesser percentage
which is the maximum allowed to be owned by a foreign corporation in a
particular jurisdiction) having the power to vote on or direct the affairs of
the entity and any person, firm, partnership, corporation or other entity
actually controlled by, controlling or under common control with such party.
         1.02  "EFFECTIVE DATE" shall mean the date upon which this AGREEMENT is
effective and shall be the date of this AGREEMENT first written above.
         1.03. "FIELD" shall mean all human uses of LICENSED PRODUCT.
         1.04  "GSK" shall mean SmithKline Beecham plc and its AFFILIATES.
         1.05  "KNOW-HOW" shall mean all present and future technical
information and know-how in the FIELD which is owned or controlled by PACIFIC
and relates to LICENSED PRODUCT and shall include, without limitation, all
formulation, biological, chemical, pharmacological, toxicological, clinical,
assay, control and manufacturing data and any other information relating to
LICENSED PRODUCT and useful for the development and commercialization of
LICENSED PRODUCT.
         1.06  "NET SALES" shall mean the gross receipts representing sales of
LICENSED PRODUCT in the TERRITORY under this AGREEMENT by GSK and its
sublicensees ("the Selling Party") to THIRD PARTIES in finished product form
(i.e., packaged and labeled for sale to the ultimate consumer) less deductions
for:
          (i)  transportation charges to the extent they are included in the
               selling price or otherwise paid by the THIRD PARTY purchaser,
               including insurance, for transporting LICENSED PRODUCT;






                                                                          Page 3
<PAGE>

             (ii) sales and excise taxes and duties and any other governmental
                  charges imposed upon the production, importation, use or sale
                  of such LICENSED PRODUCT;
            (iii) trade, quantity and cash discounts and/or trade rebates (in
                  each case, excluding advertising and promotional
                  considerations included in the selling price ) allowed on
                  LICENSED PRODUCT;
             (iv) allowances or credits to customers on account of rejection or
                  return of LICENSED PRODUCT or on account of retroactive price
                  reductions affecting such LICENSED PRODUCT.
      Sales between GSK and its sublicensees shall be excluded from the
computation of NET SALES and no royalties will be payable on such sales.
         1.07 "LICENSED PRODUCT" shall mean all products concerning or relating
to appetite suppression, meal replacement products used in weight management,
weight loss and/or weight management under development by PACIFIC as of the
Effective Date and/or marketed by PACIFIC under the brand name "Satietrol(R)" as
of the EFFECTIVE DATE, the manufacture, use, sale or import of which, but for
the license granted under this AGREEMENT, infringes any PATENT or employs any
KNOW HOW; together with all improvements, line extensions and enhancements to
such products created by or on behalf of PACIFIC during the term of the License
Agreement.
         1.08 "PACIFIC" shall mean Pacific Health Laboratories Inc. and its
AFFILIATES.
         1.09 "PATENTS" shall mean all patents and patent applications in the
FIELD which are or become owned or controlled by PACIFIC, or to which PACIFIC
otherwise has, now or in the future, the right to grant licenses, which
generically or specifically claim LICENSED PRODUCT, a process for manufacturing
or formulating LICENSED PRODUCT, an intermediate used in such process or a use
of LICENSED PRODUCT. Included within the definition of PATENTS are all
continuations, continuations-in-part, divisions, patents of addition, reissues,
renewals or extensions thereof and all SPCs. Also included within the definition
of PATENTS are any patents or patent applications which generically or
specifically claim any improvements on LICENSED PRODUCT or intermediates or
manufacturing processes required or useful for production of LICENSED PRODUCT






                                                                          Page 4
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which are developed by PACIFIC, or which PACIFIC otherwise has the right to
grant licenses, now or in the future, during the term of this AGREEMENT. The
current list of patent applications and patents encompassed within PATENTS is
set forth in Appendix A attached hereto.
         1.10 "PER PRODUCT BASIS" shall mean each distinct form or presentation
or use of LICENSED PRODUCT, for example, and without limitation to the
foregoing, a meal replacement product is a distinct form of LICENSED PRODUCT to
a pre-meal beverage, and the addition of vitamins to an existing formulation
will not constitute a distinct form or presentation of LICENSED PRODUCT. In
determining whether a particular LICENSED PRODUCT is a distinct form or
presentation, no account will be taken of minor changes, such as flavor,
packaging or enhancements to an existing form or presentation of LICENSED
PRODUCT. In the event that two existing forms and/or presentations of LICENSED
PRODUCT are packaged in combination and sold together to THIRD PARTIES, the NET
SALES pertaining to such a combination will be apportioned between each
individual form or presentation of such LICENSED PRODUCTS in accordance with the
relative selling price of each such LICENSED PRODUCT when sold individually by
GSK and/or its sublicensees.
       1.11 "SPC" shall mean a right based upon a PATENT to exclude others from
making, using or selling LICENSED PRODUCT, such as a Supplementary Protection
Certificate
       1.12 "TERRITORY" shall mean worldwide.
       1.13 "THIRD PARTY(IES)" shall mean any party other than GSK, PACIFIC and
their respective AFFILIATES.
       1.14 "USA" shall mean the United States of America, including all of its
territories and possessions.

2.       GRANT AND RIGHT OF FIRST REFUSAL
         --------------------------------
         2.01 PACIFIC hereby grants to GSK an exclusive license, with the right
to grant sublicenses under PATENTS and KNOW-HOW to make, have made, use, sell,
offer for sale, and import LICENSED PRODUCT, in the FIELD, in the TERRITORY,
subject to the other terms and conditions of this AGREEMENT. The rights to make,





                                                                          Page 5
<PAGE>

have made, use and sell shall include all activities concerning the subject
matter of PATENTS and KNOW-HOW which activities would, but for the license
herein granted, infringe PATENTS and KNOW-HOW.
         2.02 In the event that GSK in its absolute discretion elects not to
develop and/or market LICENSED PRODUCTS in any particular country and notifies
PACIFIC of this intention, then GSK's exclusive license shall terminate in
respect of LICENSED PRODUCTS in such country only and such exclusive rights
shall vest in PACIFIC. PACIFIC shall not seek customers or establish any branch
outside of any country in which PACIFIC regains such exclusive rights from GSK
("PACIFIC COUNTRY") in connection with LICENSED PRODUCT or maintain any
distribution depot for the LICENSED PRODUCT outside of a PACIFIC COUNTRY.
PACIFIC warrants and undertakes that it will impose this same obligation upon
its licensees and distributors of LICENSED PRODUCT within a PACIFIC COUNTRY. In
the event that a) GSK fails to submit, within [*] from "Launch by GSK of
LICENSED PRODUCT in USA", a written description of GSK's intent to launch
LICENSED PRODUCT in respect of any particular country, or b) LICENSED PRODUCT is
not launched within [*] after "Launch by GSK of LICENSED PRODUCT in USA" by GSK
in countries for which a description of GSK's intent to launch LICENSED PRODUCT
was submitted under Section 2.02 (a), then such a country shall be deemed to be
a PACIFIC COUNTRY.
        2.03 PACIFIC hereby grants to GSK the right of first refusal to obtain
an exclusive license in the TERRITORY to make, have made, use, sell, offer for
sale, and import product, with the right to grant sublicenses, in respect of all
new product development concerning or relating to appetite suppression, meal
replacement for weight management, weight loss and/or weight management not
covered by PATENTS or KNOW-HOW and in respect of which PACIFIC intends to use a
THIRD PARTY to further develop and/or commercialize such new product, upon terms
to be mutually negotiated by the parties in good faith. PACIFIC shall grant GSK
an Exclusive Period of ninety (90) days following notification of each such new
product development to negotiate and agree the terms of an exclusive license. In
the event that PACIFIC and GSK fail to agree on mutually acceptable terms for
the exclusive license during such period, then PACIFIC shall be free to
negotiate and enter into a license with a THIRD PARTY, provided that in no event






                                                                          Page 6
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will PACIFIC offer a license to such THIRD PARTY on terms more favorable than
the terms that were acceptable to GSK but unacceptable to PACIFIC. The term
`Exclusive Period' shall mean that PACIFIC will not, nor will it permit its
directors, AFFILIATES, representatives or agents to do, directly or indirectly,
any of the following:
negotiate, undertake, authorize, recommend, propose or enter into any
transaction involving such new product development ("Competing Transaction"); or
    a) facilitate, encourage, solicit or initiate or in any way engage in any
       discussion, negotiation or submission of a proposal or offer in respect
       of a Competing Transaction; or
    b) furnish or cause to be furnished to any THIRD PARTY any information
       concerning the new product development in connection with a Competing
       Transaction; or
    c) otherwise cooperate in any way with or assist or participate in,
       facilitate or encourage, any effort or attempt by any THIRD PARTY to do
       or seek any of the foregoing.
This Section 2.03 shall not apply in the event that PACIFIC is subject to a
Change of Control. For the purpose of this Section 2.03, "Change of Control"
will take place if control of more than fifty percent (50%) of the ownership of
PACIFIC is obtained by any THIRD PARTY that does not have direct or indirect
control or ownership of PACIFIC as at the EFFECTIVE DATE.

3.       PAYMENTS, EQUITY AND ROYALTIES
         ------------------------------
         3.01 In consideration for the license under PATENTS and KNOW-HOW
granted to GSK in this AGREEMENT, GSK shall make the following payments to
PACIFIC, up to an aggregate maximum of [*], in the specified incremental
amounts, within thirty (30) days after the occurrence of the following
milestones:
(a) EFFECTIVE DATE                                              $ 1,000,000
(b) [*]
(c) [*]
(d) [*]






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provided that:

(1)  each such payment shall be made only one time regardless of how many times
     such milestones are achieved and regardless of how many LICENSED PRODUCTS
     achieve such milestones, and no payment shall be owed for a milestone which
     is not reached;
(2)  notwithstanding the above, each of the milestones pertaining to "EFFECTIVE
     DATE" [*] will be paid by GSK to PACIFIC within 10 working days after each
     such milestone is achieved;
(3)  all milestones shall become due and payable, to the extent not already paid
     by GSK to PACIFIC in the event of [*].
(4)  each such payment shall be non-refundable and non-creditable to GSK;
(5)  the determination of whether or not a particular milestone has been
     achieved shall be made in good faith by GSK in its sole and absolute
     discretion;
(6)  by the term [*];
(7)  In the event that GSK elects in its sole and absolute discretion to
     terminate this AGREEMENT prior to [*], then GSK will provide to PACIFIC
     (free of charge) all results derived from GSK's further evaluation of
     LICENSED PRODUCTS, as set out in Section 3.01 (6), to the extent only that
     such results are specific to LICENSED PRODUCT, and PACIFIC shall have a
     non-exclusive right to use such results (without the right to disclose,
     sub-license or assign the use of such results to a THIRD PARTY) but only to
     the extent such use is related to the LICENSED PRODUCT from which such
     results were derived.
(8)  By the term [*].
(9)  By the term [*].
(10) By the term [*].
(11) By the term [*].
(12) [*].




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         3.02 Contemporaneously with the execution of this AGREEMENT, the
parties hereto shall execute or procure the execution of a Stock Purchase
Agreement.
         3.03 As further consideration for the license under PATENTS and KNOW
HOW granted to GSK under this AGREEMENT and subject to the provisions of this
Section 3, GSK shall pay a Patent Royalty to PACIFIC for NET SALES of LICENSED
PRODUCT in respect of which there is a granted, unchallenged, and valid PATENT
which claims LICENSED PRODUCT at the time such NET SALES occur. Patent Royalties
will be payable by GSK to PACIFIC on a PER PRODUCT BASIS in respect of LICENSED
PRODUCTS sold by GSK in the USA and Canada. GSK's Patent Royalty obligations
under this Section 3.03 shall become effective in each country of the TERRITORY
at such time as a valid and unchallenged PATENT is granted in such country
claiming the LICENSED PRODUCT sold by GSK. GSK shall not dispute the validity of
a PATENT for purposes of this Section 3.03 unless GSK or PACIFIC has received
notification from a THIRD PARTY challenging the validity of the PATENT. GSK's
Patent Royalty obligations under Paragraph 3.03 shall expire on a country by
country basis upon the expiration of the last remaining enforceable PATENT
claiming the LICENSED PRODUCT sold in such country. Patent Royalties shall be
reduced by fifty percent (50%) in those countries in which there is no issued
patent claiming the LICENSED PRODUCT sold in such country ("Know How Royalty").
In the event that the Know How Royalty becomes payable by GSK to PACIFIC in any
particular country, the obligation to make payments under such Know How Royalty
shall terminate and GSK will have no further obligation to make such payments
after ten (10) years from First Commercial Sale of first LICENSED PRODUCT in
such country. As soon as reasonably practicable and, in any event, before the
first launch of LICENSED PRODUCTS into a country other than USA and Canada, GSK
and PACIFIC shall determine an appropriate Patent Royalty rate for the country
concerned. Such a Patent Royalty rate shall not exceed the Patent Royalty rates
agreed for USA and Canada, as set out below:







                                                                          Page 9
<PAGE>

         A) COMPUTATION OF PERIOD OF NET SALES USED TO DETERMINE PATENT ROYALTY
RATE IN USA AND CANADA
The royalty rates to be applied to NET SALES in a particular country in any
calendar quarter shall be determined by reference to the NET SALES in such
country during that calendar quarter together with the NET SALES in such country
of the preceding three (3) calendar quarters. Notwithstanding the above, the NET
SALES in a particular country to be used in determining the royalty rate in
respect of the first four calendar quarters from First Commercial Sale within
such country shall be the aggregate total NET SALES to the end of the calendar
quarter in respect of which a royalty payment is to be calculated.
         B)  DETERMINATION OF ROYALTY RATE IN USA AND CANADA
The royalty rate will be determined by reference to the period of NET SALES set
out in Section 3.03 (A) above. The royalty rate will be applied to NET SALES
achieved in a particular country in the most recent completed calendar quarter,
as follows:
                  i) [*], and
                  ii) [*], and
                  iii) [*].
         C)  COMPUTATION OF ROYALTY PAYMENT IN USA AND CANADA
It is agreed that, subject to the provisions of this Section 3, the royalties to
be paid by GSK to PACIFIC will be calculated as follows:
                  i)  [*].
                  ii) [*]:
                  x)  [*];
                  y)  [*].; and
                  z)  [*].
         3.04 An appropriate adjustment of the Patent Royalties and Know How
Royalties for NET SALES of LICENSED PRODUCT formulated in combination with one
or more additional therapeutically active ingredients shall be mutually agreed
upon, when appropriate, in good faith, by the parties.
         3.05 In the event that a THIRD PARTY initiates any legal or
administrative proceeding challenging the validity, scope or enforceability of a
PATENT claiming LICENSED PRODUCT sold on the date of such a challenge in any
particular country of the TERRITORY, then the Patent Royalty obligation under
Paragraph 3.03 in such country shall be amended during such challenge period





                                                                         Page 10
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such that only fifty percent (50%) of the Patent Royalty otherwise due and
payable in such country will continue to be paid by GSK to PACIFIC in accordance
with the terms of this AGREEMENT and fifty percent (50%) of the Patent Royalty
otherwise due and payable in such country shall be retained by GSK during the
pendency of the proceeding. If the validity and enforceability of (i) any
individual PATENT claiming the LICENSED PRODUCT sold in such particular country
is upheld by a court or other legal or administrative tribunal from which no
appeal is or can be taken, then GSK shall pay the retained Patent Royalty plus
all interest accruing to such retained Patent Royalty to PACIFIC, or (ii) all
the PATENT(S) claiming the LICENSED PRODUCT sold in a particular country are not
upheld by such court or other legal or administrative tribunal, then the
retained Patent Royalty shall be for GSK's account, GSK shall retain the license
granted herein in such country and the royalty to be paid by GSK to PACIFIC
shall be limited to the Know How Royalty for the period set out in Section 3.03.
         3.06 Subject to the provisions of Section 7.02 (ii), any and all
filing, maintenance and prosecution costs ("Maintenance Costs") incurred by GSK
which are related to PATENTS shall be fully creditable against any future
payments owed to PACIFIC by GSK under this AGREEMENT.
         3.07 In no circumstances will the deduction of Third Party Payments (as
defined in Section 4.02) and Maintenance Costs reduce royalty payments owed by
GSK to PACIFIC in respect of any one calendar quarter by more than fifty percent
(50%) of the royalty due and payable prior to such deduction ("Royalty
Threshold"). Uncredited Third Party Payments and Maintenance Costs will be
applied and credited to all future payments owed by GSK to PACIFIC until they
are fully credited.
         3.08 Patent Royalties will be reduced by fifty percent (50%) in the
event that LICENSED PRODUCT faces "Substantial Competition". [*].

4.       COMPULSORY LICENSES AND THIRD PARTY LICENSES
         --------------------------------------------
         4.01 In the event that a governmental agency in any country grants or
compels PACIFIC to grant a license to any THIRD PARTY for LICENSED PRODUCT, GSK
shall have the benefit in such country or territory of the terms granted to such
THIRD PARTY to the extent that such terms are more favorable than those of this
AGREEMENT.





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         4.02 If, during the term of this AGREEMENT, GSK, in its sole
discretion, deems it necessary to seek or exercise or execute a license from any
THIRD PARTY in order to avoid infringement of intellectual property owned or
controlled by such THIRD PARTY as a result of the exercise by GSK and/or its
sublicensees of the license herein granted, fifty percent (50%) of any royalties
or other fees paid to such THIRD PARTY ("Third Party Payments") under such
license shall be deducted from royalties otherwise due to PACIFIC under this
AGREEMENT. Uncredited Third Party Payments will be applied and credited to all
future payments owed by GSK to PACIFIC until they are fully credited. GSK shall
notify and consult with PACIFIC prior to entering into any such license with a
THIRD PARTY.

     5.  DEVELOPMENT AND SUPPLY OF PRODUCT
         ---------------------------------
         5.01 As of the EFFECTIVE DATE, and during the term of the AGREEMENT,
GSK shall, subject to the terms of Section 8.02, have full control,
responsibility and authority over research, development and commercialization of
LICENSED PRODUCT in the TERRITORY. GSK will exercise its reasonable efforts and
diligence in developing and commercializing LICENSED PRODUCT in accordance with
its business, legal, medical and scientific judgment. In the event that GSK
decides not to launch each and every form or presentation of LICENSED PRODUCT in
any particular country, such a decision in and of itself shall not be construed
as or deemed a failure on the part of GSK to exercise its reasonable efforts and
diligence in developing and commercializing LICENSED PRODUCT in such country.
         5.02 GSK shall keep PACIFIC informed on a semi-annual basis of the
progress of GSK's efforts to develop and commercialize LICENSED PRODUCT in the
TERRITORY.
         5.03 PACIFIC shall provide to GSK, at GSK's request, reasonable
technical assistance within its area of expertise concerning development,
production and commercialization of LICENSED PRODUCT. Provision of such
technical assistance shall include, but not be limited to, visits by PACIFIC
personnel to GSK, at PACIFIC's expense, and visits by GSK personnel to PACIFIC,







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at GSK's expense, at times and for periods of time upon which the parties will
agree, and the supply of any KNOW-HOW that GSK may require.
         5.04 [*].
         5.05 GSK will be responsible for the manufacture and supply of LICENSED
PRODUCT. PACIFIC will assist GSK in arranging for due diligence to be carried
out on the manufacturing and packaging of LICENSED PRODUCT at its current
site(s).

 6.      EXCHANGE OF INFORMATION AND CONFIDENTIALITY
         -------------------------------------------
         6.01 Promptly after the EFFECTIVE DATE, PACIFIC shall disclose and
supply to GSK all KNOW-HOW within PACIFIC's possession which was not already
supplied to GSK prior to the EFFECTIVE DATE. Thereafter, PACIFIC shall promptly
disclose and supply to GSK any further KNOW-HOW that may become known to
PACIFIC.
         6.02 During the term of this AGREEMENT and for five (5) years
thereafter, irrespective of any termination earlier than the expiration of the
term of this AGREEMENT, PACIFIC and GSK shall not use or reveal or disclose to
THIRD PARTIES any confidential information received from the other party or
otherwise developed by either party in the performance of activities in
furtherance of this AGREEMENT without first obtaining the written consent of the
disclosing party, except as may be otherwise provided herein, or as may be
required for purposes of investigating, developing, manufacturing or marketing
LICENSED PRODUCT or for securing essential or desirable authorizations,
privileges or rights from governmental agencies, or is required to be disclosed
to a governmental agency or is necessary to file or prosecute patent
applications concerning LICENSED PRODUCT or to carry out any litigation
concerning LICENSED PRODUCT. This confidentiality obligation shall not apply to
such information which is or becomes a matter of public knowledge, or is already
in the possession of the receiving party, or is disclosed to the receiving party
by a THIRD PARTY having the right to do so, or is subsequently and independently
developed by employees of the receiving party or AFFILIATES thereof who had no
knowledge of the confidential information disclosed, or is required by law to be







                                                                         Page 13
<PAGE>

disclosed. The parties shall take reasonable measures to assure that no
unauthorized use or disclosure is made by others to whom access to such
information is granted.
         6.03 Nothing herein shall be construed as preventing GSK from
disclosing any information received from PACIFIC hereunder to a sublicensee or
distributor of GSK, provided, in the case of a sublicensee or distributor, such
sublicensee or distributor has undertaken a similar obligation of
confidentiality with respect to the confidential information. Nothing herein
shall be construed as preventing PACIFIC from disclosing any information
received from GSK hereunder to a banker, investor or distributor of PACIFIC,
provided, in the case of a banker, investor or distributor, such banker,
investor or distributor has undertaken a similar obligation of confidentiality
with respect to the confidential information. PACIFIC shall not be permitted to
disclose any information received from GSK hereunder to a sublicensee of PACIFIC
or other THIRD PARTY with regard to LICENSED PRODUCT. In the event that GSK
terminates this AGREEMENT in its entirety prior to [*], then PACIFIC will be
entitled to use and disclose the results of such study to a THIRD PARTY provided
that GSK shall, at GSK's sole election, be entitled to redact any reference to
GSK from the details of the study prior to such disclosure.
         6.04 All confidential information disclosed by one party to the other
shall remain the intellectual property of the disclosing party. In the event
that a court or other legal or administrative tribunal, directly or through an
appointed master, trustee or receiver, assumes partial or complete control over
the assets of a party to this AGREEMENT based on the insolvency or bankruptcy of
such party, the bankrupt or insolvent party shall promptly notify the court or
other tribunal (i) that confidential information received from the other party
under this AGREEMENT remains the property of the other party and (ii) of the
confidentiality obligations under this AGREEMENT. In addition, the bankrupt or
insolvent party shall, to the extent permitted by law, take all steps necessary
or desirable to maintain the confidentiality of the other party's confidential
information and to ensure that the court, other tribunal or appointee maintains
such information in confidence in accordance with the terms of this AGREEMENT.
         6.05 No public announcement or other disclosure to THIRD PARTIES
concerning the existence of or terms of this AGREEMENT shall be made, either



                                                                         Page 14
<PAGE>

directly or indirectly, by any party to this AGREEMENT without first obtaining
the approval of the other party and agreement upon the nature and text of such
announcement or disclosure. The party desiring to make any such public
announcement or other disclosure shall inform the other party of the proposed
announcement or disclosure at least five (5) business days prior to public
release, and shall provide the other party with a written copy thereof, in order
to allow such other party to comment upon such announcement or disclosure. Each
party agrees that it shall cooperate fully with the other with respect to all
disclosures regarding this AGREEMENT to the Securities Exchange Commission and
any other governmental or regulatory agencies, including requests for
confidential treatment of proprietary information of either party included in
any such disclosure.
         6.06 PACIFIC shall not submit for written or oral publication any
manuscript, abstract or the like which includes data or other information
relating to LICENSED PRODUCT or other information generated and provided by GSK
without first obtaining the prior written consent of GSK. GSK's contribution
shall be noted in all publications or presentations by acknowledgment or
coauthorship, whichever is appropriate.
         6.07 Nothing in this AGREEMENT shall be construed as preventing or in
any way inhibiting either party from complying with statutory and regulatory
requirements governing the development, manufacture, use and sale or other
distribution of LICENSED PRODUCT in any manner which it reasonably deems
appropriate, including, for example, by disclosing to regulatory authorities
confidential or other information received from the other party or THIRD
PARTIES.
         6.08 The reporting of adverse events related to LICENSED PRODUCT to
regulatory authorities in the TERRITORY shall be performed in accordance with
the Pharmacovigilance Agreement attached to this AGREEMENT as Appendix B.

7.       PATENT PROSECUTION AND LITIGATION
         ---------------------------------
         7.01 Each party shall have and retain sole and exclusive title to all
inventions, discoveries and know-how which are made, conceived, reduced to
practice or generated by its employees, agents, or other persons acting under
its authority in the course of or as a result of this AGREEMENT. Each party




                                                                         Page 15
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shall own a fifty percent (50%) undivided interest in all such inventions,
discoveries and know-how made, conceived, reduced to practice or generated
jointly by employees, agents, or other persons acting under the authority of
both parties in the course of or as a result of this AGREEMENT. Except as
expressly provided in this AGREEMENT, each joint owner may make, use, sell,
keep, license, assign, or mortgage such jointly owned inventions, discoveries
and know-how, and otherwise undertake all activities a sole owner might
undertake with respect to such inventions, discoveries and know-how, without the
consent of and without accounting to the other joint owner.
         7.02 Each party shall promptly notify the other upon the making,
conceiving or reducing to practice of any invention or discovery under Section
7.01 concerning LICENSED PRODUCT. With respect to any such invention,
                  (i)    GSK shall have the first right, using in-house or
                         outside legal counsel selected at GSK's sole
                         discretion, to prepare, file, prosecute, maintain and
                         extend patent applications and patents concerning all
                         such inventions and discoveries related to LICENSED
                         PRODUCT in the TERRITORY owned in whole by GSK or
                         jointly by GSK and PACIFIC with appropriate credit to
                         PACIFIC's representatives, including the naming of such
                         parties as inventors where appropriate and in
                         accordance with the relevant legal requirements. GSK
                         may solicit PACIFIC's advice and review of the nature
                         and text of such patent applications and important
                         prosecution matters related thereto in reasonably
                         sufficient time prior to filing thereof, and GSK shall
                         take into account PACIFIC's reasonable comments related
                         thereto.
                  (ii)   PACIFIC shall, using in-house or outside legal counsel
                         approved by each of GSK and PACIFIC, prepare, file,
                         prosecute, maintain and extend patent applications and
                         patents concerning all such inventions and discoveries
                         related to LICENSED PRODUCT, including PATENTS owned in
                         whole or controlled by PACIFIC, for which PACIFIC shall
                         bear the costs. PACIFIC shall solicit GSK's advice and
                         review of the nature and text of such patent
                         applications and important prosecution matters related
                         thereto in reasonably sufficient time prior to filing




                                                                         Page 16
<PAGE>

                         thereof, and PACIFIC shall take into account GSK's
                         reasonable comments related thereto.

                 (iii)   If GSK, prior or subsequent to filing certain patent
                         applications on any inventions or discoveries which are
                         owned jointly by PACIFIC and GSK, elects not to file,
                         prosecute or maintain such patent applications or
                         ensuing patents or certain claims encompassed by such
                         patent applications or ensuing patents in any country
                         of the TERRITORY, GSK shall give PACIFIC notice thereof
                         within a reasonable period prior to allowing such
                         patent applications or patents or such certain claims
                         encompassed by such patent applications or patents to
                         lapse or become abandoned or unenforceable, and PACIFIC
                         shall thereafter have the right, at its sole expense,
                         to prepare, file, prosecute and maintain patent
                         applications and patents or divisional applications
                         related to such certain claims encompassed by such
                         patent applications or patents concerning all such
                         inventions and discoveries in countries of its choice
                         throughout the world.
                  (iv)   The party filing patent applications for jointly owned
                         inventions and discoveries shall do so in the name of
                         and on behalf of both GSK and PACIFIC. Each of PACIFIC
                         and GSK shall hold all information it presently knows
                         or acquires under this Paragraph which is related to
                         all such patents and patent applications as
                         confidential subject to the provisions of Section 6.
         7.03 PACIFIC warrants and represents that it has disclosed to GSK the
complete texts of all patent applications filed by PACIFIC as of the EFFECTIVE
DATE which relate to LICENSED PRODUCT in the TERRITORY as well as all
information received as of the EFFECTIVE DATE concerning the institution or
possible institution of any interference, opposition, re-examination, reissue,
revocation, nullification or any official proceeding involving a PATENT anywhere
in the TERRITORY. PACIFIC further warrants and represents that it will disclose
to GSK the complete texts of all patent applications filed by PACIFIC after the




                                                                         Page 17
<PAGE>

EFFECTIVE DATE which relate to LICENSED PRODUCT in the TERRITORY as well as all
information received after the EFFECTIVE DATE concerning the institution or
possible institution of any interference, opposition, re-examination, reissue,
revocation, nullification or any official proceeding involving a PATENT anywhere
in the TERRITORY. In addition to GSK's rights under Section 7.02, GSK shall have
the right to review all such pending applications and other proceedings and make
recommendations to PACIFIC concerning them and their conduct. PACIFIC agrees to
keep GSK promptly and fully informed of the course of patent prosecution or
other proceedings including by providing GSK with copies of substantive
communications, search reports and third party observations submitted to or
received from patent offices throughout the TERRITORY. GSK shall provide such
patent consultation to PACIFIC at no cost to PACIFIC. GSK shall hold all
information disclosed to it under this section as confidential subject to the
provisions of Section 6.
         7.04 GSK shall have the right, but not the obligation, to assume
responsibility for any PATENT or any part of a PATENT, which PACIFIC intends to
abandon or otherwise cause or allow to be forfeited. PACIFIC shall give GSK
reasonable written notice prior to abandonment or other forfeiture of any PATENT
or any part of a PATENT so as to permit GSK to exercise its rights under this
Section 7.04.
         7.05 In the event of the institution of any suit by a THIRD PARTY
against PACIFIC, GSK or its sublicensees or distributors for patent infringement
involving the manufacture, use, sale, distribution or marketing of LICENSED
PRODUCT anywhere in the TERRITORY, the party sued shall promptly notify the
other party in writing. GSK shall have the right, but not the obligation, to
defend such suit at its own expense and shall notify PACIFIC as to whether or
not GSK intends to defend such a suit within ten (10) working days of GSK
becoming aware of the institution of the suit. PACIFIC and GSK shall provide
reasonable assistance to one another and reasonably cooperate in any such
litigation at the other's request without expense to the requesting party.
         7.06 In the event that PACIFIC or GSK becomes aware of actual or
threatened infringement of a PATENT anywhere in the TERRITORY, that party shall
promptly notify the other party in writing. GSK shall have the first right, but
not the obligation, to bring, at its own expense, an infringement action against
any THIRD PARTY and to use PACIFIC's name in connection therewith and to name
PACIFIC as a party thereto. If GSK does not commence a particular infringement



                                                                         Page 18
<PAGE>

action within ninety (90) days of receipt of the notice of infringement, then
PACIFIC, after notifying GSK in writing, shall be entitled to bring such
infringement action at its own expense. The party conducting such action shall
have full control over its conduct, including settlement thereof subject to
Section 7.08. In any event, PACIFIC and GSK shall provide reasonable assistance
to one another and shall reasonably cooperate in any such litigation at the
other's request without expense to the requesting party.
         7.07 PACIFIC and GSK shall recover their respective actual
out-of-pocket expenses, or equitable proportions thereof, associated with any
litigation or settlement thereof from any recovery made by any party. Any excess
amount shall be shared by the parties and distributed proportionately between
GSK and PACIFIC (calculated on the basis of the parties' respective financial
interest in the sales of LICENSED PRODUCT), provided that PACIFIC's share of the
excess amount shall be presumed to be equal to the royalties which would
otherwise be due to PACIFIC in the event that such excess amount were to be
treated as NET SALES of LICENSED PRODUCT by GSK or its sublicensees under this
AGREEMENT.
         7.08 The parties shall keep one another informed of the status of and
of their respective activities regarding any litigation or settlement thereof
concerning LICENSED PRODUCT, provided however that no settlement or consent
judgment or other voluntary final disposition of any suit defended or action
brought by a party pursuant to this Section 7 may be entered into without the
consent of the other party if such settlement would require the other party to
be subject to an injunction or to make a monetary payment or would otherwise
adversely affect the other party's rights under this AGREEMENT.
         7.09 GSK shall have the right but not the obligation to seek extensions
of the terms of PATENTS. At GSK's request, PACIFIC shall either authorize GSK to
act as PACIFIC's agent for the purpose of making any application for any
extensions of the term of PATENTS and provide reasonable assistance therefor to
GSK or shall diligently seek to obtain such extensions, in either event, at
PACIFIC's expense.
         7.10 At GSK's request, PACIFIC shall seek to obtain SPCs based on
PATENTS or authorize GSK to obtain SPCs based on PATENTS on PACIFIC's behalf.




                                                                         Page 19
<PAGE>

Where GSK holds a relevant marketing authorization issued by a competent
regulatory authority, GSK shall, at its sole discretion, provide to PACIFIC a
copy of said marketing authorization and any information necessary for the
purpose of obtaining an SPC based on a PATENT.
         7.11 At GSK's request, PACIFIC shall cooperate with GSK to obtain
"pipeline" protection for PATENTS which may be available under the patent laws
of countries in the TERRITORY in which the patent laws thereof are amended to
provide improved protection for LICENSED PRODUCT.
         7.12 Notwithstanding Sections 7.09 and 7.10, PACIFIC shall have the
right, but not the obligation, to seek extensions of the terms of PATENTS and to
seek to obtain SPCs based on PATENTS at its own expense.

8.       TRADEMARKS AND TRANSITIONAL PERIOD
         ----------------------------------
         8.01 GSK shall be solely responsible for the selection of all
trademarks, which it employs in connection with LICENSED PRODUCT in the
TERRITORY. PACIFIC shall assign to GSK the worldwide rights, title and interest
in and to the registered and unregistered "SATIETROL" trademarks, together with
any associated trademark applications (the "Marks") and associated internet
domain names owned by PACIFIC (as set out in Appendix C). GSK shall thereafter
assume all costs and responsibilities for registering, maintaining, and
defending the Marks and domain names in the TERRITORY. Such assignment shall be
free of charge to GSK in each country in which the Marks are assigned to GSK
until the expiration of GSK's Patent Royalty and Know How Royalty obligation in
such country, after which GSK shall pay to PACIFIC a royalty of [*] on the
annual NET SALES of product, in the USA only, to which the Marks are affixed by
GSK. Such a trademark royalty shall be payable for a maximum period of five (5)
years per product. For the avoidance of doubt, product shall not include
different variants, enhancements or improvements to an existing presentation of
such product. GSK shall be entitled to affix the Marks to any product and will
not be under any obligation to commercialize LICENSED PRODUCT using the Marks.
In the event that GSK terminates this AGREEMENT in its entirety prior to Launch
by GSK of LICENSED PRODUCT in USA, then GSK shall promptly assign back to




                                                                         Page 20
<PAGE>

PACIFIC the worldwide rights, title and interest in and to the Marks, together
with any associated trademark applications and internet domain names assigned to
GSK by PACIFIC under this Section 8.01.
         8.02 PACIFIC shall cooperate with and assist GSK (at GSK's expense) in
recording such trademark assignments at the appropriate trademarks offices and
in effecting a prompt transfer to GSK of such domain names as are associated
with the Marks with the relevant THIRD PARTY internet service provider.
         8.03 For the period of time only prior to First Commercial Sale of
LICENSED PRODUCT by GSK ("Transitional Period"), GSK hereby grants PACIFIC an
exclusive, royalty-free license, under the PATENTS and KNOW HOW, to
commercialize the pre-meal variant of LICENSED PRODUCT ("PMV"). PACIFIC shall
only commercialize PMV in the USA and such other countries (as set out in
Appendix D) in which PACIFIC commercializes PMV as at the EFFECTIVE DATE.
Further and subject to PACIFIC's strict compliance with the terms of Section
8.04, PACIFIC shall be entitled to so commercialize PMV under the Marks. PACIFIC
undertakes and warrants that, during the Transitional Period, PACIFIC will only
commercialize PMV within the Health Food Channel. For the purposes of this
Section 8, "Health Food Channel" shall mean health food stores and web sites
specific to health food only. " Health Food Channel" also includes health food
chains such as GNC, Whole Foods, Vitamin Shop, Vitamin World and the website
Drugstore.com, whether or not Drugstore.com would otherwise be considered within
the Health Food Channel. "Health Food Channel" does not include grocery stores,
food stores, convenience outlets, mass merchandisers, drug stores and any other
regional wholesaler or direct buying account or distributors and their
respective internet and mail order operations. Further, PACIFIC undertakes and
warrants that a) during the Transitional Period, PACIFIC will utilize no more
than the amount of time, resource and money dedicated to advertising and
promotion of PMV by PACIFIC per calendar quarter as at the EFFECTIVE DATE, and
b) PACIFIC will immediately cease all use of the Marks and will discontinue all
manufacturing, marketing, support, supply and sale of PMV to THIRD PARTIES prior
to First Commercial Sale of LICENSED PRODUCT by GSK.







                                                                         Page 21
<PAGE>

         8.04 GSK hereby grants to PACIFIC an exclusive license, for the
duration of the Transitional Period only, to use the Marks in connection with
PACIFIC's continued commercialization of PMV and MRP ( as defined in Section
8.05) in accordance with the terms set out in this Section 8. PACIFIC agrees
that GSK will have the right to control the nature of use of the Marks on PMV
and MRP to ensure that the Marks are used properly in accordance with GSK's
standards of quality control and trademark usage and that use of the Marks by
PACIFIC inures to the benefit of GSK. PACIFIC shall provide GSK with samples of
all literature, brochures, signs, advertising and packaging prepared by or on
behalf of PACIFIC in connection with the use of the Marks. When using the Marks
under this AGREEMENT, PACIFIC undertakes to comply substantially with all laws
pertaining to use of the goods enforced at any time in the covered territory.
PACIFIC agrees to cooperate in all matters involving infringement of any of the
Marks.
         8.05 GSK hereby grants to PACIFIC, for the term of this AGREEMENT, an
exclusive license, under the PATENTS and KNOW HOW, to commercialize within the
Health Food Channel only, and within the USA and Canada only, the meal
replacement variant (in powder form only) of LICENSED PRODUCT ("MRP"). Such an
exclusive license shall permit GSK to commercialize MRP in accordance with the
terms of this AGREEMENT except in the Health Food Channel. PACIFIC's rights
under this Section 8.05 are subject to PACIFIC's strict compliance with each of
the following terms and conditions:
         (1) PACIFIC shall not assign, delegate, sub-contract or further
sub-license any rights granted to PACIFIC under this Section 8.05 to any THIRD
PARTY; and
         (2) The sub-license granted by GSK to PACIFIC under this Section 8.05
is concerned with and pertains only to a powder presentation of MRP. PACIFIC
hereby undertakes that it will not develop MRP or cause MRP to be developed in
any form (for example, a ready to eat presentation of a meal replacement
product) other than a powder presentation; and
         (3) PACIFIC shall cease all use of the Marks and will discontinue all
manufacturing, marketing, support, supply and sale of MRP under the Marks to
THIRD PARTIES prior to First Commercial Sale of LICENSED PRODUCT by GSK; and





                                                                         Page 22
<PAGE>

         (4) PACIFIC undertakes and warrants that it will commercialize MRP only
within the Health Food Channel.
         (5) As further consideration for the sub-license to PACIFIC of certain
rights under PATENTS and KNOW HOW under this Section 8.05, PACIFIC shall pay a
royalty to GSK ("PACIFIC ROYALTY") in respect of NET SALES of MRP achieved by
PACIFIC in the USA and Canada during the period commencing [*] years after
Launch by GSK of LICENSED PRODUCT in USA. The PACIFIC ROYALTY shall be
calculated and paid on the same basis as that set out in Section 3.03 (A), (B)
and (C), and Section 9. This sublicense shall be terminated forthwith on GSK
serving notice of termination pursuant to Section 10.02 or Section 10.05.
Termination of PACIFIC's rights under this Section 8.05 shall be without
prejudice to the survival of the remaining terms and conditions of this
AGREEMENT.


9. STATEMENTS AND REMITTANCES
    -------------------------
         9.01 GSK shall keep and require its AFFILIATES and sublicensees to keep
complete and accurate records of all sales of LICENSED PRODUCT under the
licenses granted herein. PACIFIC shall have the right, at PACIFIC's expense,
through an independent certified public accountant or like person reasonably
acceptable to GSK, to examine such records during regular business hours during
the life of this AGREEMENT and for six (6) months after its termination;
provided, however, that such examination shall not take place more often than
once a year and shall not cover such records for more than the preceding two (2)
years and provided further that such accountant shall report to PACIFIC only as
to the accuracy of the royalty statements and payments.
          9.02 Within forty five (45) days after the end of each calendar
quarter, GSK shall provide a true accounting of all LICENSED PRODUCT sold by
GSK, its AFFILIATES and its sublicensees during such quarter. Such accounting
shall show sales on a country-by-country basis. Simultaneously with the
submission of the accounting, GSK shall pay to PACIFIC all the royalties due to
PACIFIC hereunder, and shall submit to PACIFIC, together with each such royalty
payment, a written royalty statement describing the calculation of royalties and
applicable exchange rates.
         9.03 All royalties due under this AGREEMENT shall be payable in US
dollars. With regard to sales made by a sublicensee of GSK only, in the event





                                                                         Page 23
<PAGE>

that governmental regulations prevent remittances from a foreign country, the
obligation of GSK to pay royalties on sales in that country shall be suspended
until such remittances are possible. PACIFIC shall have the right, upon giving
written notice to GSK, to receive payment in that country in local currency.
         9.04 Any tax, duty or other levy paid or required to be withheld by GSK
on account of royalties payable to PACIFIC under this AGREEMENT shall be
deducted from the amount of royalties otherwise due. GSK shall secure and send
to PACIFIC proof of any such taxes, duties or other levies withheld and paid by
GSK or its sublicensees for the benefit of PACIFIC.
         9.05 Monetary conversion from the currency of a foreign country, in
which LICENSED PRODUCT is sold, into U.S. Dollars shall be calculated at the
actual average rates of exchange for the pertinent calendar quarter as used by
GSK in producing its quarterly and annual accounts, as confirmed by GSK's
auditors.

10.      TERM AND TERMINATION
         --------------------
         10.01 Unless otherwise terminated, this AGREEMENT shall expire upon the
later of a) expiration, lapse or invalidation of the last remaining PATENT in
the TERRITORY which claims LICENSED PRODUCT, or b) expiration of GSK's
obligation (if any) to pay a Know How Royalty to PACIFIC in the TERRITORY.
Following expiration or termination of this AGREEMENT, other than due to
material breach of this AGREEMENT by GSK or GSK's termination of this AGREEMENT
described in Section 10.03 or Pacific's termination of this AGREEMENT under
Section 10.05, GSK shall be entitled to make, have made, use and sell LICENSED
PRODUCT and to use KNOW-HOW in the TERRITORY without any further payment
obligations to PACIFIC. For the avoidance of doubt, the expiration of this
AGREEMENT shall result in a fully paid up PATENT and KNOW HOW license for the
benefit of GSK. If this AGREEMENT is terminated by PACIFIC due to material
breach by GSK, or pursuant to Section 10.03 or 10.05, GSK shall have no further
rights or licenses with respect to the PATENTS or LICENSED PRODUCT (except as
described in Section 10.07 and 11.02).
         10.02 If either party materially fails or neglects to perform covenants
or provisions of this AGREEMENT and if such default is not corrected within




                                                                         Page 24
<PAGE>

sixty (60) days after receiving written notice from the other party with respect
to such default, and in the case of any payment obligation hereunder within ten
(10) working days after receiving written notice from the other party with
respect to such default, such other party shall have the right to terminate this
AGREEMENT by giving written notice to the party in default provided the notice
of termination is given within six (6) months of the default and prior to
correction of the default.
         10.03 In the event that GSK notifies PACIFIC under Section 3.01 (6) or
Section 3.01(8) that GSK does not intend to proceed with further development
and/or commercialization of LICENSED PRODUCTS, then this AGREEMENT shall
terminate forthwith.
         10.04 GSK may terminate this AGREEMENT on a country by country basis,
or in its entirety, by giving PACIFIC at least thirty (30) days written notice
thereof at any time based on a reasonable determination by GSK, using the same
standards GSK would use in assessing whether or not to continue development of a
product of its own making, that the patent, medical/scientific, technical,
regulatory or commercial profile (including, but without limitation, the failure
to achieve the milestones set out in Section 3.01) of LICENSED PRODUCT does not
justify continued development or commercialization of LICENSED PRODUCT.
Termination of this AGREEMENT in all countries of the TERRITORY shall constitute
a termination of this AGREEMENT in its entirety. For the avoidance of doubt, it
is agreed that a failure of any Quantitative Analysis carried out prior to
Launch of Licensed Product in the USA will be deemed a sufficient and reasonable
reason for GSK to exercise its right to terminate this AGREEMENT on grounds of
commercial profile. Quantitative Analysis will comprise a BASES II study and/or
(at GSK's sole election) a Test Market. Quantitative Analysis will be deemed
successful in the event that the results of such Quantitative Analysis are
successful in all material respects, including, but not limited to, a
demonstration that sales of LICENSED PRODUCT are likely to [*]. A "Test Market"
will comprise a form of controlled market testing of LICENSED PRODUCT, with no
restriction on packaging, branding, pricing or other strategic commercial
issues, which will in no circumstances be directed at more than fifteen percent
(15%) of the marketplace in the USA.





                                                                         Page 25
<PAGE>

         10.05 Either party may terminate this AGREEMENT if, at any time, the
other party shall file in any court or agency pursuant to any statute or
regulation of any state or country, a petition in bankruptcy or insolvency or
for reorganization or for an arrangement or for the appointment of a receiver or
trustee of the party or of its assets, or if the other party proposes a written
agreement of composition or extension of its debts, or if the other party shall
be served with an involuntary petition against it, filed in any insolvency
proceeding, and such petition shall not be dismissed with sixty (60) days after
the filing thereof, or if the other party shall propose or be a party to any
dissolution or liquidation, or if the other party shall make an assignment for
the benefit of creditors.
         10.06 Notwithstanding the bankruptcy of PACIFIC, or the impairment of
performance by PACIFIC of its obligations under this AGREEMENT as a result of
bankruptcy or insolvency of PACIFIC, GSK shall be entitled to retain the
licenses granted herein, subject to PACIFIC 's rights to terminate this
AGREEMENT for reasons other than bankruptcy or insolvency as expressly provided
in this AGREEMENT.
         10.07 All rights and distribution rights granted under or pursuant to
this AGREEMENT by PACIFIC to GSK are, and shall otherwise be deemed to be, for
purposes of Section 365(n) of the U.S. Bankruptcy Code, licenses of rights to
"intellectual property" as defined under Section 101(52) of the U.S. Bankruptcy
Code. The parties agree that GSK, as a licensee of such rights under this
AGREEMENT, shall retain and may fully exercise all of its rights and elections
under the U.S. Bankruptcy Code, subject to performance by GSK of its preexisting
obligations under this AGREEMENT. The parties further agree that, in the event
of the commencement of a bankruptcy proceeding by or against PACIFIC under the
U.S. Bankruptcy Code, GSK shall be entitled to a complete duplicate of (or
complete access to, as appropriate) any such intellectual property and all
embodiments of such intellectual property, and same, if not already in its
possession, shall be promptly delivered to GSK (a) upon any such commencement of
a bankruptcy proceeding upon written request therefor by GSK, unless PACIFIC
elects to continue to perform all of its obligations under this AGREEMENT, or
(b) if not delivered under (a) above, upon the rejection of this AGREEMENT by or
on behalf of PACIFIC upon written request therefor by GSK, provided, however,
that upon PACIFIC's (or its successor's) written notification to GSK that it is





                                                                         Page 26
<PAGE>

again willing and able to perform all of its obligations under this AGREEMENT,
GSK shall promptly return all such tangible materials to PACIFIC, but only to
the extent that GSK does not require continued access to such materials to
enable GSK to perform its obligations under this AGREEMENT.

11.      RIGHTS AND DUTIES UPON TERMINATION
         ----------------------------------
         11.01 Upon termination of this AGREEMENT, PACIFIC shall have the right
to retain any sums already paid by GSK hereunder.
         11.02 Upon termination of this AGREEMENT in its entirety or with
respect to LICENSED PRODUCT in any country, GSK shall notify PACIFIC of the
amount of LICENSED PRODUCT GSK and its sublicensees then have on hand, the sale
of which would, but for the termination, be subject to royalty, and GSK and its
sublicensees shall thereupon be permitted to sell that amount of LICENSED
PRODUCT for a period not exceeding twelve (12) months of such termination,
provided that GSK shall pay the royalty thereon at the time herein provided for.
This Section 11.02 shall not apply in the event of termination of this AGREEMENT
by GSK as a result of a material breach by PACIFIC.
         11.03 Termination of this AGREEMENT shall terminate all outstanding
obligations and liabilities between the parties arising from this AGREEMENT
except those described in Sections 6,7,8,9,10,11, and any other obligations
otherwise provided by this AGREEMENT which have accrued. In addition, any other
provision required to interpret and enforce the parties' rights and obligations
under this AGREEMENT shall also survive, but only to the extent required for the
full observation and performance of this AGREEMENT.
         11.04 Termination of the AGREEMENT in accordance with the provisions
hereof shall not limit remedies, which may be otherwise available in law or
equity.

12. WARRANTIES AND REPRESENTATIONS
    ------------------------------
         12.01 PACIFIC warrants and represents that it owns the entire right,
title and interest in the PATENTS listed in Appendix A, or filed by or on behalf
of PACIFIC pursuant to Section 7, and the KNOW-HOW provided to GSK under this






                                                                         Page 27
<PAGE>

AGREEMENT, and that it otherwise has the right to enter into this AGREEMENT.
PACIFIC further warrants and represents that it will not encumber any such
PATENTS and KNOW-HOW with liens, mortgages, security interests or otherwise.
PACIFIC further warrants and represents that there is nothing in any THIRD PARTY
agreement PACIFIC has entered into as of the EFFECTIVE DATE which, in any way,
will directly limit PACIFIC's ability to perform all of the obligations
undertaken by PACIFIC hereunder, and that it will not enter into any AGREEMENT
after the EFFECTIVE DATE under which PACIFIC would incur any such limitations.
         12.02 Nothing in this AGREEMENT shall be construed as a warranty that
PATENTS are valid or enforceable as of the EFFECTIVE DATE or that they will be
so during the term of this AGREEMENT. PACIFIC hereby warrants and represents
that it has no present knowledge from which it can be inferred that PATENTS are
invalid or that their exercise would infringe patent rights of THIRD PARTIES.
PACIFIC further warrants and represents that it has no present knowledge that
the process of manufacturing LICENSED PRODUCT, and all intermediates of such
process, will infringe patent rights of THIRD PARTIES in the TERRITORY.
         12.03 PACIFIC warrants and represents that it has not, up through and
including the EFFECTIVE DATE, omitted to furnish GSK with any information in its
possession concerning LICENSED PRODUCT or the transactions contemplated by this
AGREEMENT, which would be material to GSK's decision to enter into this
AGREEMENT and to undertake the commitments and obligations set forth herein.
         12.04 PACIFIC warrants and represents that it has no present knowledge
of the existence of any pre-clinical or clinical data or information concerning
the LICENSED PRODUCT which it has not provided to GSK prior to the EFFECTIVE
DATE which suggests that there may exist quality, toxicity, safety and/or
efficacy concerns which may materially impair the utility and/or safety of the
LICENSED PRODUCT.
         12.05 PACIFIC warrants and represents that it will not knowingly engage
in any activity regarding development of LICENSED PRODUCT outside of the FIELD
which is or ought to be recognized by PACIFIC as posing a present or potential
harm to the development of LICENSED PRODUCT in the FIELD in the TERRITORY.
PACIFIC further warrants that it will require all of its AFFILIATES and, in the





                                                                         Page 28
<PAGE>

event that this exclusive license becomes non-exclusive with regard to LICENSED
PRODUCT in any particular country pursuant to Section 2 of this AGREEMENT,
sublicensees of PRODUCT to enter in a binding agreement with PACIFIC which
contains the same warranty and representation as outlined in this Section 12.05.
         12.06 GSK shall defend, indemnify and hold harmless PACIFIC and its and
their respective officers, directors, employees, agents, successors and assigns
from any loss, damage, or liability, including reasonable attorney's fees,
resulting from any claim, complaint, suit, proceeding or cause of action against
any of them attributable to the manufacturing or marketing of LICENSED PRODUCT
by or on behalf of GSK (or its permitted sublicensees), or alleging physical or
other injury, including death, arising out of the administration, utilization
and/or ingestion of LICENSED PRODUCT manufactured, sold or otherwise provided to
the injured party by GSK (or its permitted sublicensees) provided:
                  (a)    GSK shall not be obligated under this Section 12.06 if
                         it is shown by evidence acceptable in a court of law
                         having jurisdiction over the subject matter and meeting
                         the appropriate degree of proof for such action, that
                         the injury was the result of the negligence or willful
                         misconduct of any employee or agent of PACIFIC or the
                         breach of any warranty or representation made by
                         PACIFIC in this AGREEMENT;
                  (b)    GSK shall have no obligation under this Section 12.06
                         unless PACIFIC (i) gives GSK prompt written notice of
                         any claim or lawsuit or other action for which it seeks
                         to be indemnified under this AGREEMENT, (ii) GSK is
                         granted full authority and control over the defense,
                         including settlement, against such claim or lawsuit or
                         other action, and (iii) PACIFIC cooperates fully with
                         GSK and its agents in defense of the claims or lawsuit
                         or other action; and
                  (e)    PACIFIC shall have the right to participate in the
                         defense of any such claim, complaint, suit, proceeding
                         or cause of action referred to in this Section 12.06
                         utilizing attorneys of its choice, at its own expense,
                         provided, however, that GSK shall have full authority





                                                                         Page 29
<PAGE>

                         and control to handle any such claim, complaint, suit,
                         proceeding or cause of action, including any settlement
                         or other disposition thereof, for which PACIFIC seeks
                         indemnification under this Section 12.06 provided that
                         GSK shall first obtain a general release and discharge
                         from all liability pertaining to the subject matter of
                         such settlement for the benefit of PACIFIC.
         12.07 PACIFIC shall defend, indemnify and hold harmless GSK and its and
their officers, directors, employees, agents, successors, sublicensees and
assigns from any loss, damage, or liability, including reasonable attorney's
fees, resulting from any claim, complaint, suit, proceeding or cause of action
against any of them attributable to the manufacturing or marketing of LICENSED
PRODUCT (including as a result of any permitted use of the Marks during the
Transitional Period set out in Section 8.03) by or on behalf of PACIFIC (or its
permitted sublicensees), or alleging physical or other injury, including death,
arising out of the administration, utilization and/or ingestion of LICENSED
PRODUCT manufactured, sold or otherwise provided to the injured party by
PACIFIC, including, in each case, where such loss, damage, or liability arises
as a result of PACIFIC exercising its rights to commercialize LICENSED PRODUCT
under Section 8 and, in the case of a PACIFIC COUNTRY, as a result of the
actions or omissions of PACIFIC's sublicensees, provided:
                  (a)    PACIFIC shall not be obligated under this Section 12.07
                         if it is shown by evidence acceptable in a court of law
                         having jurisdiction over the subject matter and meeting
                         the appropriate degree of proof for such action, that
                         the injury was the result of the negligence or willful
                         misconduct of any employee or agent of GSK or the
                         breach of any warranty or representation made by GSK in
                         this AGREEMENT;
                  (b)    PACIFIC shall have no obligation under this Section
                         12.07 unless GSK (i) gives PACIFIC prompt written
                         notice of any claim or lawsuit or other action for
                         which it seeks to be indemnified under this AGREEMENT,
                         (ii) PACIFIC is granted full authority and control over
                         the defense, including settlement, against such claim





                                                                         Page 30
<PAGE>

                         or lawsuit or other action, and (iii) GSK cooperates
                         fully with PACIFIC and its agents in defense of the
                         claims or lawsuit or other action; and
                  (c)    GSK shall have the right to participate in the defense
                         of any such claim, complaint, suit, proceeding or cause
                         of action referred to in this Section 12.07 utilizing
                         attorneys of its choice, at its own expense, provided,
                         however, that PACIFIC shall have full authority and
                         control to handle any such claim, complaint, suit,
                         proceeding or cause of action, including any settlement
                         or other disposition thereof, for which GSK seeks
                         indemnification under this Section 12.07 provided that
                         PACIFIC shall first obtain a general release and
                         discharge from all liability pertaining to the subject
                         matter of such settlement for the benefit of GSK.
         12.08 During the entire period of time commencing on Launch by GSK of
LICENSED PRODUCT in USA and until five (5) years after the expiration of this
AGREEMENT or earlier termination, each party shall obtain and/or maintain,
respectively, at its sole cost and expense, product liability insurance in
amounts, respectively, which are reasonable and customary in the respective
industries of the parties for companies of comparable size and activities.
Notwithstanding anything in this AGREEMENT to the contrary, PACIFIC shall
maintain product liability insurance in an amount not less than ten (10) million
US dollars per occurrence (or claim) and in the aggregate annually. Such product
liability insurance shall insure against all liability, including liability for
personal injury, physical injury and property damage. Each party shall provide
written proof of the existence of such insurance to the other party upon
request.

13.      FORCE MAJEURE
         -------------
         13.01 If the performance of any part of this AGREEMENT by either party,
or of any obligation under this AGREEMENT, is prevented, restricted, interfered
with or delayed by reason of any cause beyond the reasonable control of the
party liable to perform, unless conclusive evidence to the contrary is provided,
the party so affected shall, upon giving written notice to the other party, be




                                                                         Page 31
<PAGE>

excused from such performance to the extent of such prevention, restriction,
interference or delay, provided that the affected party shall use its reasonable
efforts to avoid or remove such causes of non-performance and shall continue
performance with the utmost dispatch whenever such causes are removed. When such
circumstances arise, the parties shall discuss what, if any, modification of the
terms of this AGREEMENT may be required in order to arrive at an equitable
solution.

14.      GOVERNING LAW AND DISPUTE RESOLUTION
         ------------------------------------
         14.01 This AGREEMENT shall be governed by the laws of the Commonwealth
of Pennsylvania and its form, execution, validity, construction and effect shall
be determined in accordance with the same.
         14.02 Any dispute, controversy or claim arising out of or relating to
this AGREEMENT (hereinafter collectively referred to as "Dispute") shall be
attempted to be settled by the parties, in good faith, by submitting each such
Dispute to appropriate senior management representatives of each party in an
effort to effect a mutually acceptable resolution thereof.
         14.03 In the event no mutually acceptable resolution of such Dispute is
achieved in accordance with Paragraph 14.02 within a reasonable period of time,
then either party shall be entitled to seek final settlement of such Dispute by
any administrative or judicial mechanism which may be available.

15.      WAIVER OF BREACH
         ----------------
         15.01 The failure of either party at any time or times to require
performance of any provision hereof shall in no manner affect its rights at a
later time to enforce the same. No waiver by either party of any condition or
term in any one or more instances shall be construed as a further or continuing
waiver of such condition or term or of another condition or term.

16.      SEPARABILITY
         ------------
         16.01 In the event any portion of this AGREEMENT shall be held illegal,
void or ineffective, the remaining portions hereof shall remain in full force
and effect.




                                                                         Page 32
<PAGE>

         16.02 If any of the terms or provisions of this AGREEMENT are in
conflict with any applicable statute or rule of law, then such terms or
provisions shall be deemed inoperative to the extent that they may conflict
therewith and shall be deemed to be modified to conform with such statute or
rule of law.
         16.03 In the event that the terms and conditions of this AGREEMENT are
materially altered as a result of Paragraphs 16.01 or 16.02, the parties will
renegotiate the terms and conditions of this AGREEMENT to resolve any
inequities.

17.      ENTIRE AGREEMENT
         ----------------
         17.01 This AGREEMENT, together with a Stock Purchase Agreement and a
Trademark Assignment, each entered into as of the EFFECTIVE DATE, constitute the
entire agreement between the parties relating to the subject matter hereof and
supersedes all previous writings and understandings. No terms or provisions of
this AGREEMENT shall be varied or modified by any prior or subsequent statement,
conduct or act of either of the parties, except that the parties may amend this
AGREEMENT by written instruments specifically referring to and executed in the
same manner as this AGREEMENT.

18.      NOTICES
         -------
         18.01 Notices required or permitted under this AGREEMENT shall be in
writing and sent by prepaid registered or certified air mail or by overnight
express mail (e.g., FedEx), or by facsimile confirmed by prepaid registered or
certified air mail letter or by overnight express mail (e.g., FedEx), and shall
be deemed to have been properly served to the addressee upon receipt of such
written communication, to the following addresses of the parties:

                  If to PACIFIC:    Pacific Health Laboratories, Inc.
                                            1480 Route 9 North
                                            Suite 204
                                            Woodbridge, NJ  07095
                                            Attention:  President
                                            Facsimile No._  732-636-7410






                                                                         Page 33
<PAGE>

                  Copy to:                  Gary A. Miller
                                            Eckert Seamans Cherin & Mellott
                                            1515 Market St., 9th Floor
                                            Philadelphia, PA 19102
                                            Facsimile No.: 215-851-8383

                  If to GSK:    Vice President and Director, Consumer Healthcare
                                Worldwide Business Development
                                SmithKline Beecham Corporation (trading as
                                GlaxoSmithKline)
                                One Franklin Plaza
                                P.O. Box 7929
                                Philadelphia, Pennsylvania 19101,  U.S.A.
                                Facsimile No.: 215-751- 4221

                  Copy to:

                           SmithKline Beecham Corporation (trading as
                           GlaxoSmithKline)
                           One Franklin Plaza (Mail Code FP2360)
                           P.O. Box 7929
                           Philadelphia, Pennsylvania  19101,  U.S.A.
                           Attention:  Corporate Law - U.S.
                           Facsimile No.: 215-751-3935

19.      ASSIGNMENT
         ----------
         19.01 This AGREEMENT and the licenses herein granted shall be binding
upon and inure to the benefit of the successors in interest of the respective
parties. Neither this AGREEMENT nor any interest hereunder shall be assignable
by either party without the written consent of the other provided, however, that
each party may assign this AGREEMENT or any part of its rights and obligations
hereunder to any AFFILIATE of such party or to any corporation with which such
party may merge or consolidate, or to which it may transfer all or substantially
all of its assets to which this AGREEMENT relates, without obtaining the consent
of the other party hereto.

20.      RECORDING
         ---------
         20.01 GSK shall have the right, at any time, to record, register, or
otherwise notify this AGREEMENT in appropriate governmental or regulatory
offices anywhere in the TERRITORY, and PACIFIC shall provide reasonable
assistance to GSK in effecting such recording, registering or notifying.





                                                                         Page 34
<PAGE>

21.      EXECUTION IN COUNTERPARTS
         -------------------------
         21.01 This AGREEMENT may be executed in any number of counterparts,
each of which shall be deemed an original but all of which together shall
constitute one and the same instrument.

         IN WITNESS WHEREOF, the parties, through their authorized officers,
have executed this AGREEMENT as of the date first written above.

SMITHKLINE BEECHAM PLC

BY:__________________

TITLE: ______________

PACIFIC HEALTH LABORATORIES INC.

BY:__________________

TITLE:_______________














                                                                         Page 35
<PAGE>




                                LICENSE AGREEMENT

                                   APPENDIX A
                                 PATENT APPENDIX
<TABLE>
<CAPTION>
------------------------ --------------------- --------------------- ---------------------------------------------------
       File No.               Serial No.            Patent No.                             Title
                             Filing Date            Issue Date
------------------------ --------------------- --------------------- ---------------------------------------------------
    Pacific 3.0-003           09/510,809            6,207,638             Nutritional Intervention Composition for
                               2/23/00               3/27/01                  Enhancing and Extending Satiety
------------------------ --------------------- --------------------- ---------------------------------------------------
<S>                      <C>                   <C>                   <C>
          [*]                    [*]                                                        [*]
------------------------ --------------------- --------------------- ---------------------------------------------------
          [*]                    [*]                                                        [*]
------------------------ --------------------- --------------------- ---------------------------------------------------
          [*]                    [*]                                                        [*]
------------------------ --------------------- --------------------- ---------------------------------------------------
          [*]                    [*]                                                        [*]
------------------------ --------------------- --------------------- ---------------------------------------------------
          [*]                    [*]                                                        [*]
------------------------ --------------------- --------------------- ---------------------------------------------------
          [*]                    [*]                                                        [*]
------------------------ --------------------- --------------------- ---------------------------------------------------
          [*]                    [*]                                                        [*]
------------------------ --------------------- --------------------- ---------------------------------------------------
          [*]                    [*]                                                        [*]
------------------------ --------------------- --------------------- ---------------------------------------------------
</TABLE>






                                                                         Page 36
<PAGE>





                                   APPENDIX B
                           PHARMACOVIGILANCE AGREEMENT
                  Procedure for Exchange of Adverse Event data



BACKGROUND:

Pacific and GSK have entered into an Agreement for the development and
commercialization of "Satietrol(R)".


DEFINITIONS
-----------
The following definitions reflect and are consistent with FDA and International
Conference on Harmonization (ICH) regulations/guidelines.

Adverse Experience (AE)
-----------------------
The ICH has defined an AE as "any untoward medical occurrence in a patient or
clinical investigation subject administered a pharmaceutical product and which
does not necessarily have to have a causal relationship with this treatment."

o   Adverse Drug Reaction (ADR)
    ---------------------------
    In the pre-approval clinical experience or in other clinical trial
    experiences The ICH has defined an ADR in clinical trials as "all noxious
    and unintended responses to a medical product related to any dose". The
    phrase "responses to a medicinal product" means that a causal relationship
    between a medicinal product and an adverse event is at least a reasonable
    possibility, i.e. the relationship cannot be ruled out.

    For marketed medical products: The ICH had defined an ADR in marketed
        medicinal products as "a response to a drug which is noxious and
        unintended and which occurs at doses normally used in man for
        prophylaxis, diagnosis or therapy of disease or for modification of
        physiological function."


o   Unexpected ADR
    --------------
    The ICH has defined an unexpected ADR as "an adverse reaction, the nature or
    severity of which is not consistent with the applicable product information
    (e.g. Investigator Brochure) for an unapproved investigational medicinal
    product.

    This definition includes an AE/adr of which the nature, specificity, or
    severity is inconsistent with the applicable product information. For an
    AE/ADR from a clinical trial, the reference document shall be the
    Investigator Brochure.





                                                                         Page 37
<PAGE>

Serious AE or Serious ADR
-------------------------
A serious AE or ADR is any untoward medical occurrence that:
* results in death
* is life-threatening
        NOTE: The term "life-threatening" in the definition of "serious" refers
    to an event in which the patient was at risk of death at the time of the
    event; it does not refer to an event which hypothetically might have
    caused death if it were more severe.
* requires inpatient hospitalization or prolongation of existing hospitalization
* results in persistent or significant disability/incapacity * is a congenital
  anomaly/birth defect.

Medical and scientific judgment should be exercised in deciding whether
expedited reporting is appropriate in other situations, such as important
medical events that may not be immediately life-threatening or result in death
or hospitalization but may jeopardize the patient or may require intervention to
prevent one of the other outcomes listed in the definition above. These should
also usually be considered serious. (Examples of such events are intensive
treatment in an emergency room or at home for allergic bronchospasm; blood
dyscrasias or convulsions that do not result in hospitalization; or development
of drug dependency or drug abuse.)

o    Non-Serious AE
     --------------
     A non-serious AE is any experience, which does not meet the definition of
serious as defined above.

     Clinical trial experiences which are not considered "serious" include:
     hospitalization for a pre-planned/elective procedure for a medical
     condition present before treatment started; a pre-existing medical
     condition which does not increase in severity or frequency following
     treatment; or an experience which is simply a treatment failure according
     to the efficacy criteria for the study.

o    Spontaneous reports
     Reports from any source other than a clinical trial source, including
     regulatory agencies, health care professionals, consumers and literature,
     shall be classified for reporting purposes as a spontaneous report.


REPORTING
---------
o    Reports of Pregnancy and Overdose
     ---------------------------------
     While such reports are not AEs or ADRs as defined herein, reports of
     pregnancies should be followed up until the outcome of the pregnancy is
     known. "Overdose" will be defined as any single dose that exceeds the
     recommended total daily dose.

o    Minimum criteria for reporting
     ------------------------------
     Initial reports should be submitted within the agreed timelines as long as
     the following minimum criteria are met:





                                                                         Page 38
<PAGE>

       an identifiable patient; a suspect medicinal product; an identifiable
       reporting source; and an event or outcome

o    Follow-up of Cases
     ------------------
     The party who is the initial recipient of an AE/ADR report shall be
     responsible for appropriate follow-up of that AE/ADR report and timely
     transmission of relevant new information to the other party.

POLICY
------
o    GSK will hold the recognized worldwide safety database for LICENSED PRODUCT
o    GSK is responsible for regulatory reporting in the TERRITORY.
o    If either party becomes aware of a safety issue they will immediately
     inform the other party.
o    Each party will inform the other party of any safety related queries from a
     regulatory authority.

DATA EXCHANGE
-------------
o    Data will be transferred in English by fax.
o    GSK is responsible for receiving and forwarding reports to and from other
     GSK sub-licensees (if applicable)
o    GSK will notify Pacific either electronically or by facsimile of all
     serious AE reports (including both clinical trial and spontaneous AEs) that
     GSK receives within two calendar days of receipt of such reports by the GSK
     Safety Department in the United Kingdom. When the minimum information
     required for reporting can not be transmitted due to translation
     difficulties, GSK shall notify Pacific within three working days of initial
     receipt of such reports.
o    GSK will notify Pacific by facsimile of any fatal or life-threatening ADRs
     within twenty-four (24) hours of receipt.
o    Pacific will provide GSK with CIOMS I forms (electronically or by
     facsimile) for all serious AEs within two (2) calendar days of receipt.
o    Pacific will notify GSK by facsimile of any fatal or life-threatening ADRs
     within twenty-four (24) hours of receipt by CPI.
o    Non-serious spontaneous AE reports received by Pacific will be submitted to
     GSK within five working days of receipt of such reports by Pacific.
o    Pacific is responsible for receiving and forwarding reports to and from
     other Pacific-licensees (if applicable).
o    GSK is responsible for receiving and forwarding reports to and from other
     GSK-sublicensees (if applicable).

LITERATURE REPORTS:

Each party shall be responsible for scanning the literature for case reports in
any territory in which it holds registration rights as set forth in this
Agreement.






                                                                         Page 39
<PAGE>

REGULATORY REPORTING:

o    Reporting (where appropriate) of domestic or foreign cases to the local
     regulatory authorities is the responsibility of the local registration
     holder.
     o   GSK shall be responsible for reporting of cases to the local regulatory
         authorities in those countries where GSK is the local registration
         holder. In some territories, regulatory submission of serious cases is
         not a requirement, but is undertaken voluntarily by GSK.
     o   Pacific shall be responsible for reporting cases (where appropriate) to
         the local regulatory authorities in those countries where Pacific is
         the local registration holder.

GSK will send PACIFIC
----------------------
Copies of end of study reports

PACIFIC will send to GSK:
-------------------------
Copies of end of study reports

PHARMACOVIGILANCE CONTACTS IN EACH PARTY:
-----------------------------------------

    For GSK:


    Contact for AEs originating in countries other
    than the Americas:
    Barbara D Jones
    Product Safety Manager
    GSK CH Research & Development
    St George's Ave
    Weybridge,
    Surrey
    UK
    Tel +44 1932 82 21 50
    Fax+44 1932 82 21 56

    Contact for AEs originating in the Americas:
    Dr Reineirio Deza
    Director, NA Medical Affairs & Safety
    GSK Consumer Healthcare
    100 Beecham Drive
    Pittsburgh, PA 15205 USA
    Tel: (412)928-1085
    Fax: (412)928-6958







                                                                         Page 40
<PAGE>


    For PACIFIC:
    ------------

     Dr Robert Portman
     President
     Pacific Healthcare Laboratories Inc.
     1480 Route 9 NorthSuite 204
     Woodbridge, NJ  07095
     Facsimile No._  732-636-7410























                                                                         Page 41
<PAGE>




                                   APPENDIX C
TRADE MARKS AND DOMAIN NAMES TO BE ASSIGNED TO GSK
DOMAIN NAME:
www.satietrol.com
TRADEMARKS:

SATIETROL - serial number: 75/742,879
SATIETROL COMPLETE  - serial number: 76/ 154,906 (application pending as at the
EFFECTIVE DATE)

(in each case registered / filed in US only)


























                                                                         Page 42
<PAGE>



                                   APPENDIX D
COUNTRIES IN WHICH PACIFIC IS ACTIVELY COMMERCIALIZING THE PMV VARIANT OF
LICENSED PRODUCT AS AT THE EFFECTIVE DATE.


BRAZIL
GUATEMALA
JAPAN
KOREA
MEXICO
SOUTH AFRICA
SINGAPORE
USA

























                                                                         Page 43