### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASH INGTON , D.C

. 20460



### Dat e: 113 0/ 13
MEMORANDUM OFFICE OF CHEM ICAL SAFETY AND POLLUT I ON PREVENTION



### SUBJECT: Hexythiazox. Registrati on Review Preliminary Risk Assessment.
PC Code: 128849 DP Barcode: D406658 Decision No. : 471595 Registration No.: 10163-277 Petition No

. : NA Regulatory Action: Registration Review Risk Assessment Type: Single Chemical Case No.: 7404 -1 Aggregate TXRNo.: NA CAS No.: 78587 -0 5-0 MRIDNo.: NA 40 CFR: 40 CFR 180.448
FROM: DonnaS. Davis, Risk

# Assesso**~ ~**  Alexandra LaMay,

### Biolo**st~~~** _ / 

# C Linda Taylor, Toxico logist**~ ~~**  c 

### R

isk Assessment Branch VI Health Effects Divi s ion ( 7509P)
THROUGH: Michael Metzger, Chief

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# J / /!L---- Risk Assessment Branch VI 

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# If Health Effects Division (7509 )
TO: Mo lly Clayton, Risk Manager Tracy Perry, Team Leader Patricia Parrott, Chief Ri sk Management and Imp lementation Branch III Pesticide Re- Evaluation Divi s ion (7508P)

Page 1 of2Hexythiazo x Registration Review Preliminary Risk Assessment
Hexythiazox is an insecticide currently registered on a wide array of agricultural crops as well as in residential settings including ornamental plantings, turf, and residential fruit and nut trees. Dietary, residential , and aggregate risks for hexythiazox were addressed in the HED me morandum entitled "Hexythiazox. Human Health Risk Assessment to Support New Uses on Alfalfa and Timothy " (D396526, D404477 , 9/25/12 , D. Davis)

. Since this recently conducted risk assessment addressed all dietary , residential , and aggregate exposures assoc iated with the registered uses ofhexythiazox, considered all available hazard and exposure data submitted to the Agency, included updated points of departure and safety/uncertainty factors, and used current HED policies and procedures, it constitutes the dietary, residential and aggregate human health preliminary risk assessment for registration review

. There are no di etary, residential or aggregate risks of concern for the registered use s of hexythiazox.
The occupational risk s associated with the use ofhexythiazox on alfalfa, timothy, field corn, and tomatoes were recently assessed in the HED memoranda entitled "Hexythiazox. Human Health Risk Assessment to Support New Uses on Alfalfa and Timothy " (0396526 , D404477 , 9/25112, D. Davis) and " Hexyt hiazox. Human Health Risk Assessment to Support Amended Use on Field Corn and New Use on Greenhouse Tomatoes " (D383744, 6/ 22/ 11, D

. D avis). Occupational scena rios not assessed in these memoranda were screened in the HED memorandum "Hexyt hiazox: Summary of Hazard and Science Policy Council (HASPOC) Meetings: Recommendations on the need for the inhalation , and acute and subchronic neurotoxicity studies" (TXR # 0056434, 10/18/12, K. Rury). Since the recently conducted occupationa l risk assessments and HA S POC screen cited above address all registered use s of hexythiazox, considered all available h azard and exposure data s ubmitted to the Agency, included updated points of departure and safety /uncertainty factors , and used current HED policies and procedures, when considered together they constitute the occupational preliminary ri s k for registration review. There are no occupational risks of concern for the registered uses of hexythiazox.

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