<PAGE>
                                                                   EXHIBIT 10.16

                                    AGREEMENT


     This Agreement is entered into by Joseph Mooibroek and 
Electropharmacology, Inc., 2301 N.W. 33rd Ct., Suite 102, Pompano Beach, 
Florida 33069 (EPI hereafter) on this 12th day of April, 1997.  Although 
written by hand, all parties agree that it is their mutual intention to enter 
into the Agreement as a final, enforceable binding agreement.  All parties 
wish to resolve all disputes and conflicts they have or might ever have 
between themselves by this agreement. This agreement replaces all other oral 
or written agreements between the parties.

1.   The parties agree that the Employment Agreement entered into 8/5/96 between
     the parties is terminated effective upon Mr. Mooibroek permitted
     resignation at the 4/1/96 telephonic board meeting of EPI, except that
     Paragraphs 17 and 20(a) shall survive and are incorporated herein.

2.   As a resolution to any and all disputes that might exist between the
     parties, they have agreed to the following paragraphs.

3.   EPI agrees to execute and deliver to Mr. Mooibroek the promissory note
     attached as Exhibit A, which shall be incorporated herein by reference. 
     Additionally, EPI will give Mr. Mooibroek a warrant to purchase 25,000
     shares of common stock at the closing price of EPI common stock on
     April 11, 1997.  Such right shall be exercised by April 11, 2007.  EPI
     acknowledges that Mr. Mooibroek is fully vested with respect to 207,236
     shares of EPI common stock at a purchase price of $5.50 a share exercisable
     on or before August 5, 2006.  The remaining options which Mr. Mooibroek may
     have had any interest in revert to EPI.  The amount of such shares is
     estimated at 384,856.  Additionally, Mr. Mooibroek had an option right
     relating to the exercise of the Herrick warrant (10% of 1.3 million
     shares).  That right, too, is voided by this Agreement.

4.   Mr. Mooibroek agrees he will not reveal to any person or entity information
     (that has not been disclosed to the public) about EPI which he learned
     exclusively during the term of his employment with EPI.  He will not use
     such above-described information for any purpose.  (The term of employment
     is 8/5/96 to 4/1/97.)

5.   All parties acknowledge that it is a material inducement for each to enter
     into this Agreement that neither makes critical and/or negative comments
     regarding Mr. Mooibroek's resignation and/or the company's business
     affairs.  The parties agree that the terms of this agreement, the
     negotiations leading up to it, other than what is expressed 




Page 1 of 22
<PAGE>

     in the Board minutes of EPI of 4/1/97, will be held confidential unless 
     required to be revealed by action of a court of competent jurisdiction.  
     The parties agree Mr. Mooibroek will have to discuss the matter and 
     disclose the agreement in his lawsuit with his former employer, AME,
     (now Orthofix Ltd.) sited in Dallas, Texas.  The parties will uses the 
     information in the press release issued April 2, 1997 in describing the
     separation of Mr. Mooibroek from his employment with EPI.

6.   Mr. Mooibroek agrees that he will cooperate with EPI in that he will, at no
     additional cost to EPI, consent to execute any and all documents necessary
     to perfect and secure patent protection that will be assigned to EPI on
     inventions made by Mooibroek (battery powered unit and multiplexing
     system).  Mr. Mooibroek agrees he will prepare and deliver to EPI by
     4/25/97 the First Draft of his disclosures of the inventions which will
     become an Exhibit to the Agreement after he cooperates with EPI in putting 
     that draft in final form (Exhibit B).

7.   The parties agrees that no non-compete clause is to be implied to be part
     of this Agreement.

8.   EPI acknowledges that the shares of common stock (in lieu of salary) which
     were assigned to Mr. Mooibroek for 1996 (5,555 shares), which have not yet
     been delivered to him by May 15, 1997.  EPI will use its best efforts to
     deliver the certificates by 4/25/97.  If the shares are not delivered to
     Mr. Mooibroek by 5/15/97, then the shares shall be declared lost and re-
     issued to Mr. Mooibroek as soon as possible.

9.   No party in entering into this agreement admits to any liability or
     wrongdoing.  All parties agree this Agreement is binding on their heirs,
     successors and assigns.

10.  The parties agree that they have entered into Mutual General Releases which
     are attached as Exhibit C which are incorporated by reference.

11.  The parties agree that each is represented by counsel; that the agreement
     will be governed by Florida law; that any dispute under the agreement will
     be litigated in a court in Broward County; and any such litigation will
     result in an award which grants attorneys fees and costs to the prevailing
     party.  In case of relocation of the corporate offices, a court of
     competent jurisdiction in any county in Florida where EPI has an office
     will be appropriate venue.

12.  If any portion of this Agreement is found to be invalid, such invalidity
     will not affect the validity of the remaining provisions.





Page 2 of 22
<PAGE>

13.  Mr. Mooibroek has been fully informed of the protections provided by the
     OLDER WORKER'S PROTECTION ACT.  Understanding that the matter has to be
     resolved for reasons that inure to each party's benefit, he has
     intentionally waived his rights to consider this matter for an additional
     21 days.  Mr. Mooibroek is aware that EPI is filing a 10K with the SEC on
     April 15, 1997.  In order for EPI to in good faith treat this matter as
     resolved, Mr. Mooibroek acknowledges his right to revoke this agreement for
     a statutorily establish seven day period and agrees he will not act to so
     revoke.

     In witness whereof, the parties have signed in Fort Lauderdale, Florida, 
this 12th day of April 1997.
                                                                              
WITNESS                                ELECTROPHARMACOLOGY, INC.              
                                                                              
/s/ Elizabeth J. du Fresne             /s/ David Saloff                        
--------------------------------       --------------------------------       
                                       David Saloff,                          
/s/ Bruce E. Loren                     Executive Vice President                
--------------------------------                                              
                                       /s/ Joseph Mooibroek                   
/s/ Elizabeth J. du Fresne             --------------------------------        
--------------------------------       Joseph Mooibroek                       

/s/ Bruce E. Loren                       
--------------------------------

     Verifying that he has agreed that Mr. Mooibroek's promissory note will 
have preference and stand before any obligations EPI has to Norton Herrick 
and/or his assigns.

                                       /s/ Norton Herrick                
                                       --------------------------------
                                       Norton Herrick 





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<PAGE>
                  PAGES 4 THROUGH 15 INTENTIONALLY LEFT BLANK. 



<PAGE>


RETURN TO: (ENCLOSE SELF-ADDRESSED STAMPED ENVELOPE)            GENERAL RELEASE

NAME:
Bruce E. Loren
ADDRESS:
        P.O. Box 1900
        Fort Lauderdale, Florida 33302

THIS INSTRUMENT PREPARED BY:

ADDRESS:
        Ruden, McClosky, Smith,
        Schuster & Russell, P.A.
        200 East Broward Boulevard
        15th Floor
        Fort Lauderdale, Florida 33301

--------------------------------------------------------------------------------
     SPACE ABOVE THIS LINE                          SPACE ABOVE THIS LINE
      FOR PROCESSING DATA                             FOR RECORDING DATA

                        KNOW ALL MEN BY THESE PRESENTS:


     That, first party, Joseph Mooibroek, for and in consideration of the sum 
of Ten and 00/100 Dollars ($10.00), and other valuable considerations, 
received from or on behalf of Electropharmacology, Inc., second party, the 
receipt whereof is hereby acknowledged,

     (Wherever used herein the terms "first party" and "second party" shall 
     include singular and plural, officers, directors, agents, attorneys, 
     employees, insurers, heirs, legal representatives, and assigns of 
     individuals, and the successors and assigns of corporations, wherever 
     the context so admits or requires.)

     HEREBY remise, release, acquit, satisfy, and forever discharge the said 
second party of and from all, and all manner of action and actions, cause and 
causes of action, suits, debts, dues, sums of money, accounts, reckonings, 
bonds, bills, specialties, covenants, contracts, controversies, agreements, 
promises, variances, trespasses, damages, judgments, executions, claims and 
demands whatsoever, in law or in equity, which said first party ever had, now 
has, or which any personal representative, successor, heir or assign of said 
first party, hereafter can, shall or may have, against said second party, 
for, upon or by reason of any claims that have been made for, upon or by 
reason of any matter, cause or thing whatsoever, from the beginning of the 
world to the day of these presents, including without limitation, any claims 
raised or that could have been raised in connection with or related to the 
first party's management of or employment by the first party; except that, 
this release is not intended to and shall not release second party from his 
obligations and duties under that certain Settlement Agreement, dated April 
12, 1997, between Electropharmacology, Inc. and Joseph Mooibroek.


Page 16 of 22

<PAGE>

     IN WITNESS WHEREOF, I have hereunto set my hand and seal, this 12th day 
of April, 1997.


Signed, sealed and delivered in presence of:  JOSEPH MOOIBROEK

/s/ ELIZABETH J. DU FRESNE                    /s/ JOSEPH MOOIBROEK
-----------------------------------          ---------------------------------
Witness Signature

   Elizabeth J. du Fresne                         Joseph Mooibroek
-----------------------------------          ---------------------------------
Printed Name                                 Printed Name

/s/ BRUCE E. LOREN                               17643 Bocaine Way
-----------------------------------          ---------------------------------
Witness Signature                            Post Office Address

   Bruce E. Loren                             Boca Raton, Florida  33487-1121
-----------------------------------
Printed Name


STATE OF FLORIDA       )
                       ) SS:
COUNTY OF BROWARD      )

     I HEREBY CERTIFY that on this day, before me, an officer duly authorized 
in the State aforesaid and in the County aforesaid to take acknowledgments, 
the foregoing instrument was acknowledged before me by _______________________
__________________________, who is personally known to me or who has produced 
______________________________ as identification.

     WITNESS my hand and official seal in the County and State last aforesaid 
this _____ day of ____________________, 19__.


                                          /s/ ELIZABETH J. DU FRESNE
                                       --------------------------------------
                                       Notary Public



                                       --------------------------------------
                                       Typed, printed or stamped name of
                                       Notary Public

My Commission Expires:






Page 17 of 22



<PAGE>


RETURN TO: (ENCLOSE SELF-ADDRESSED STAMPED ENVELOPE)            GENERAL RELEASE

NAME:
Bruce E. Loren
ADDRESS:
        P.O. Box 1900
        Fort Lauderdale, Florida 33302

THIS INSTRUMENT PREPARED BY:

ADDRESS:
        Ruden, McClosky, Smith,
        Schuster & Russell, P.A.
        200 East Broward Boulevard
        15th Floor
        Fort Lauderdale, Florida 33301

--------------------------------------------------------------------------------
     SPACE ABOVE THIS LINE                          SPACE ABOVE THIS LINE
      FOR PROCESSING DATA                             FOR RECORDING DATA

                        KNOW ALL MEN BY THESE PRESENTS:


     That, first party, Electropharmacology, for and in consideration of the 
sum of Ten and 00/100 Dollars ($10.00), and other valuable considerations, 
received from or on behalf of Joseph Mooibroek, second party, the receipt 
whereof is hereby acknowledged,

     (Wherever used herein the terms "first party" and "second party" shall 
     include singular and plural, officers, directors, agents, attorneys, 
     employees, insurers, heirs, legal representatives, and assigns of 
     individuals, and the successors and assigns of corporations, wherever 
     the context so admits or requires.)

     HEREBY remise, release, acquit, satisfy, and forever discharge the said 
second party of and from all, and all manner of action and actions, cause and 
causes of action, suits, debts, dues, sums of money, accounts, reckonings, 
bonds, bills, specialties, covenants, contracts, controversies, agreements, 
promises, variances, trespasses, damages, judgments, executions, claims and 
demands whatsoever, in law or in equity, which said first party ever had, now 
has, or which any personal representative, successor, heir or assign of said 
first party, hereafter can, shall or may have, against said second party, 
for, upon or by reason of any claims that have been made for, upon or by 
reason of any matter, cause or thing whatsoever, from the beginning of the 
world to the day of these presents, including without limitation, any claims 
raised or that could have been raised in connection with or related to the 
second party's management of or employment by the first party; except that, 
this release is not intended to and shall not release second party from his 
obligations and duties under that certain Settlement Agreement, dated April 
12, 1997, between Electropharmacology, Inc. and Joseph Mooibroek.


Page 18 of 22

<PAGE>

     IN WITNESS WHEREOF, I have hereunto set my hand and seal, this 12th day 
of April, 1997.


Signed, sealed and delivered in presence of:  ELECTROPHARMACOLOGY, INC.

/s/ ARUP SEN                             By:   /s/ DAVID SALOFF        (L.S.)
-----------------------------------          ---------------------------------
Witness Signature                            As  Executive Vice President
                                               -------------------------------

   Arup Sen                                     
-----------------------------------          ---------------------------------
Printed Name                                 Printed Name

/s/ BRUCE E. LOREN
-----------------------------------          ---------------------------------
Witness Signature                            Post Office Address

   Bruce E. Loren
-----------------------------------
Printed Name


STATE OF FLORIDA       )
                       ) SS:
COUNTY OF BROWARD      )

     I HEREBY CERTIFY that on this day, before me, an officer duly authorized 
in the State aforesaid and in the County aforesaid to take acknowledgments, 
the foregoing instrument was acknowledged before me by _______________________ 
________________________, the ________________________ of Electropharmacology, 
Inc., a Florida corporation, freely and voluntarily under authority duly 
vested in him/her by said corporation and that the seal affixed thereto is 
the true corporate seal of said corporation.  He/She is personally known to 
me or who has produced ______________________________ as identification.

     WITNESS my hand and official seal in the County and State last aforesaid 
this _____ day of ____________________, 1997.


                                          /s/ ELIZABETH J. DU FRESNE
                                       --------------------------------------
                                       Notary Public



                                       --------------------------------------
                                       Typed, printed or stamped name of
                                       Notary Public

My Commission Expires:






Page 19 of 22

<PAGE>

                                 PROMISSORY NOTE

$128,700.00                                             City of Fort Lauderdale
                                                               State of Florida

   FOR VALUE RECEIVED, ELECTROPHARMACOLOGY, INC., a Florida corporation 
("Borrower"), promise to pay to the order of JOSEPH MOOIBROEK ("MOOIBROEK"), 
the principal amount of ONE HUNDRED AND TWENTY EIGHT THOUSAND SEVEN HUNDRED 
DOLLARS AND 00/100 DOLLARS ($128,700.00).
   
   This Note shall be paid according to the following terms:
   
   $15,000 due no later than April 18, 1997;
   $15,000 due no later than May 1, 1997;
   $15,700 due no later than May 15, 1997;
   $10,000 due no later than June 1, 1997;
   $10,000 due no later than June 15, 1997;
   $10,000 due no later than July 1, 1997;
   $10,000 due no later than July 15, 1997;
   $10,000 due no later than August 1, 1997;
   $10,000 due no later than August 15, 1997;
   $10,000 due no later than September 1, 1997;
   $11,000 due no later than September 15, 1997; and
   $ 2,000 due no later than October 1, 1997
   
   All payments to be received no later than 5:00 p.m. on the date that such 
payment is due. This Note may be prepaid at any time without premium or fee.

   If Borrower obtains financing in an amount greater than One Million 
Dollars ($1,000,000), or if Borrower defaults on any payment to be made 
herein and any such Default continues for more than ten (10) calendar days 
from the date payment is due, the entire principal sum shall become due and 
payable at the option of Mooibroek. Failure to exercise this option shall not 
constitute a waiver of the right to exercise the same at any other time.

   Upon the occurrence of any default under this Note, the unpaid principal 
of this Note and any part thereof, shall bear interest at the rate of 
eighteen (18) per cent after Default until paid (the "Default Rate"). The 
prevailing party in any action to collect upon this Note shall be entitled to 
all costs of collection, including reimbursement of their attorney's fees, 
including any appeals.

   All payments on this Note shall be payable in lawful currency of the 
United States of America at Joseph Mooibroek, 17643 Bocaire Way, Boca Raton, 
Florida 33487 in immediately available funds.





Page 20 of 22

<PAGE>

   Borrower hereby (a) waives demand, presentment for payment, notice of 
nonpayment, protest, notice of protest and all other notice, filing of suit 
and diligence in collecting this Note; and (b) agrees that Mooibroek shall 
not be required first to institute any suit, or to exhaust its remedies 
against Borrower or any other person or party to become liable hereunder in 
order to enforce payment of this Note.

   Anything contained herein to the contrary notwithstanding, if for any 
reason the effective rate of interest on this Note should exceed the maximum 
lawful rate, the effective rate shall be deemed reduced to and shall be such 
maximum lawful rate, and any such sums of interest which have been collected 
in excess of such maximum lawful rate shall be applied as a credit against 
the unpaid balance due hereunder.

   The provisions of this Note may from time to time be amended, modified or 
waived only by written agreement executed by Borrower and Mooibroek.

   This Note is made under and governed by the laws of the State of Florida, 
without regard to conflict of laws or principles.

   WAIVER OF JURY TRIAL. BORROWER AND MOOIBROEK HEREBY KNOWINGLY, 
VOLUNTARILY AND INTENTIONALLY WAIVE ANY RIGHT EITHER MAY HAVE TO A TRIAL BY 
JURY IN RESPECT OF ANY LITIGATION BASED ON THIS NOTE, OR ARISING OUT OF, UNDER 
OR IN CONNECTION WITH THIS NOTE, OR ANY COURSE OF CONDUCT, COURSE OF DEALING, 
STATEMENTS (WHETHER VERBAL OR WRITTEN) OR ACTIONS OF ANY PARTY WITH RESPECT 
HERETO.  THIS PROVISION IS A MATERIAL INDUCEMENT FOR MOOIBROEK'S ACCEPTING THIS
NOTE FROM BORROWER.
                                      
                                      BORROWER:
                                      
                                      ELECTROPHARMACOLOGY, INC.,
                                      a Florida corporation
                                      

                                      By:  /s/ DAVID SALOFF
                                          -------------------------------------
                                          David Saloff, Vice Chairman/Chief 
                                          Financial Officer





Page 21 of 22


<PAGE>

STATE OF FLORIDA       )
                       ) SS:
COUNTY OF BROWARD      )

   I HEREBY CERTIFY that on this day, before me, an officer duly authorized 
in the State aforesaid and in the County aforesaid to take acknowledgments, 
the foregoing instrument was acknowledged before me by _______________, the 
________________ of _______________, a _______________ corporation, freely 
and voluntarily under authority duly vested in him/her by said corporation 
and that the seal affixed thereto is the true corporate seal of said 
corporation. He/She is personally known to me or who has produced 
______________ as identification.

   WITNESS my hand and official seal in the County and State last aforesaid 
this __ day of ___________, 19__.


                                                 ELIZABETH J. DU FRESNE
                                                 --------------------------
                                                 Notary Public



                                                 --------------------------
                                                 Typed, printed or stamped 
                                                 name of Notary Public

My Commission Expires:





Page 22 of 22