EX10.10



 Exhibit 10.10 

SIXTH AMENDMENT TO LEASE 
  

	I.	PARTIES AND DATE. 

 This Sixth Amendment to Lease (the “Amendment”)
dated January 31, 2014, is by and between THE IRVINE COMPANY LLC, a Delaware limited liability company, formerly The Irvine Company, a Delaware corporation (“Landlord”), and SPECTRUM PHARMACEUTICALS, INC., a Delaware
corporation (“Tenant”). 
  

	II.	RECITALS. 

 On January 16, 1997, Landlord and Tenant entered into a lease for space
in a building located at 157 Technology, Irvine, California (“157 Technology Premises”), which lease was amended by a First Amendment to Lease dated March 25, 2004, by a Second Amendment to Lease dated March 7, 2006, by a
Third Amendment to Lease dated February 12, 2006, by a Fourth Amendment to Lease dated July 29, 2009, and by a Fifth Amendment to Lease dated November 21, 2013 (the “Fifth Amendment”). The foregoing lease, as so
amended is hereinafter referred to as the “Lease”. 
 Landlord and Tenant each desire to modify the Lease to correct
certain typographical errors contained in the Fifth Amendment as are set forth in “III. MODIFICATIONS” next below. 
  

	III.	MODIFICATIONS. 

 A. The schedule for the “Basic Rent for the 157 Technology
Premises” contained in Subsection III.B(4) of the Fifth Amendment is hereby deleted in its entirety, and substituted therefor shall be the following: 

“Basic Rent for the 157 Technology Premises: 

Commencing July 1, 2016, the Basic Rent for the 157 Technology Premises shall be Forty Two Thousand Nine Hundred Dollars ($42,900.00) per
month, based on $1.25 per rentable square foot. 
 Commencing July 1, 2017, the Basic Rent for the 157 Technology Premises shall be
Forty Four Thousand Nine Hundred Fifty-Nine Dollars ($44,959.00) per month, based on $1.31 per rentable square foot. 
 Commencing
July 1, 2018 and continuing through the Expiration Date, the Basic Rent for the 157 Technology Premises shall be Forty Seven Thousand Eighteen Dollars ($47,018.00) per month, based on $1.37 per rentable square foot.” 

 

	IV.	GENERAL. 

 A. Effect of Amendments. The Lease shall remain in full force and
effect except to the extent that it is modified by this Amendment. 
 B. Entire Agreement. This Amendment embodies the entire
understanding between Landlord and Tenant with respect to the modifications set forth in “III. MODIFICATIONS” above and can be changed only by a writing signed by Landlord and Tenant. 

C. Counterparts. If this Amendment is executed in counterparts, each is hereby declared to be an original; all, however, shall
constitute but one and the same amendment. In any action or proceeding, any photographic, photostatic, or other copy of this Amendment may be introduced into evidence without foundation. 

D. Defined Terms. All words commencing with initial capital letters in this Amendment and defined in the Lease shall have the same
meaning in this Amendment as in the Lease, unless they are otherwise defined in this Amendment. 

  
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 E. Corporate and Partnership Authority. If Tenant is a corporation or partnership, or is
comprised of either or both of them, each individual executing this Amendment for the corporation or partnership represents that he or she is duly authorized to execute and deliver this Amendment on behalf of the corporation or partnership and that
this Amendment is binding upon the corporation or partnership in accordance with its terms. 
  

	V.	EXECUTION. 

 Landlord and Tenant executed this Amendment on the date as set forth in
“I. PARTIES AND DATE.” above. 
  

									
	 LANDLORD:
  

THE IRVINE COMPANY LLC
	 		 	 TENANT:
  

SPECTRUM PHARMACEUTICALS, INC.

	a Delaware limited liability company	 		 	a Delaware corporation
					
	By	 	 /s/ Steven M. Case
	 		 	By	 	 /s/ Brett L. Scott

		 	Steven M. Case, Executive Vice President	 		 	Name	 	Brett L. Scott
		 	Office Properties	 		 	Title	 	Senior Vice President
					
	By	 	 /s/ Michael T. Bennett
	 		 	By	 	 /s/ Abraham N. Oler

		 	Michael T. Bennett, Senior Vice President	 		 	Name	 	Abraham N. Oler
		 	Operations, Office Properties	 		 	Title	 	Vice President of Operations


  
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