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                                  EXHIBIT 10.25

                      AMENDED AND RESTATED PROMISSORY NOTE
            (for acquisition of IGEN International, Inc. Common Stock
                       under the 1994 Stock Option Plan)
                          Effective as of July 22, 2000
                             Gaithersburg, Maryland

WHEREAS, on July 22, 2000, IGEN International, Inc. ("IGEN" or the "LENDER")
made a loan in the sum of One million Six hundred and Forty-nine thousand
dollars ($1,649,000.00) (the "LOAN") to the undersigned (the "Borrower")
pursuant to the authority granted by a resolution of the Board of Directors of
the Lender in July 2000 (the "RESOLUTION"); and

WHEREAS, the Lender and the Borrower now wish to amend the promissory note
evidencing the Loan to correct the terms of the Loan to make the terms
consistent with the Borrower's and the Lender's intention and with the
Resolution.

FOR VALUE RECEIVED, the Borrower promises to pay to the order of the Lender, the
sum of One million Six hundred and Forty-nine thousand dollars ($1,649,000.00),
together with interest thereon as set forth below, at 16020 Industrial Drive,
Gaithersburg, Maryland 20877, or at such other place as the Lender may designate
without offset. This instrument is referred to as the "NOTE."

A.   SPECIFIC TERMS

     5.  INTEREST:  From the date hereof until repayment, interest shall accrue
     hereunder at a rate of 6.62% per annum and will compound and be payable
     annually. Interest payable hereunder shall be calculated for the actual
     days elapsed on the basis of a 365-day year.

     6.  PAYMENTS:  The entire principal amount and any accrued and unpaid
     interest shall become due and payable on July 22, 2007 or as accelerated
     under Section A(3) or B(2) below, whichever occurs first.

     7.  ACCELERATION:  This Note will become due and payable not later than the
     thirtieth (30th) day after the Borrower's employment with IGEN ceases for
     any reason.

     8. SECURITY: To secure payment of this Note, the Borrower has transferred,
     pledged and granted a first priority security interest in, and delivered to
     the Lender his certificates for, eighty thousand (80,000) shares of IGEN
     Common Stock (the "COLLATERAL"). The fair market value of the Collateral at
     least equals the amount borrowed under this Note on the date it was signed.

B.   GENERAL CONDITIONS

     13. The Lender shall apply all of the Borrower's payments and prepayments
     first to any accrued and unpaid interest and then to the unpaid principal
     balance of this Note. Payment by the Borrower of any amount due under this
     Note shall consist of delivery to the Lender of either cash, bank cashier's
     or certified check payable to the Lender without endorsement. Payment of
     principal or interest may be made prior to the date upon which it is due
     without penalty.

     14. Upon the occurrence of any one or more of the Events of Default set
     forth under Section B(3) below, the entire unpaid principal balance of this
     Note, together with all accrued and unpaid interest hereunder, shall, at
     the Lender's option, become immediately due and payable without notice of
     demand of any kind.


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     15.  An "EVENT OF DEFAULT" shall mean the occurrence of any one or more of
     the following events:

         (a) the failure by the Borrower to pay when due any amount due
             hereunder;

         (b) if the Borrower shall become insolvent or shall generally not pay
             his debts as they become due, or shall file a voluntary petition
             under any Federal insolvency legislation (the "BANKRUPTCY ACT")
             seeking liquidation, reorganization or to effect a plan or other
             arrangement with creditors, or shall be unable, or shall admit in
             writing his or her inability to pay his debts as they become due,
             or shall file an answer admitting the jurisdiction of the
             Bankruptcy Court and the material allegations of any involuntary
             petition filed pursuant to the Bankruptcy Act, or an order for
             relief under the Bankruptcy Act shall be entered, or if the
             Borrower shall make an assignment or arrangement or enter into a
             trust indenture for the benefit of its creditors, or shall apply
             for, consent to, or suffer the appointment of any receiver or
             trustee for any of his property; or

         (c) if any lien, writ of attachment or execution or any similar process
             is imposed, issued or levied against the Collateral or all or a
             substantial part of Borrower's other property, which judgment,
             lien, writ or process is not discharged, released, stayed, bonded
             or vacated within fifteen (15) days after its entry, imposition,
             issue or levy.

     16. In an Event of Default, the Lender shall have the right to proceed to
     collect the indebtedness due under this Note by action or proceeding
     against the Collateral or against the Borrower or against both the
     Collateral and the Borrower, without first having to exhaust its remedies
     against any other collateral or party, and such action or proceeding shall
     not be construed as a waiver of any other rights or powers to proceed
     thereafter against any other collateral or party. In an Event of Default,
     the Lender shall have all rights in the Collateral provided by the Uniform
     Commercial Code.

     17. No delay or omission by the Lender in exercising or enforcing any of
     its powers, rights, privileges, remedies, or discretions hereunder shall
     operate as a bar thereto on that occasion or on any other occasion. No
     waiver of any default hereunder or as otherwise provided by law shall
     operate as a waiver of or bar to any other default hereunder, or as a
     continuing waiver.

     18. The Borrower shall pay all costs and expenses, including, without
     limitation, reasonable attorney's and expert's fees, expenses and
     disbursements, in connection with the protection or enforcement of any of
     the Lender's rights against the Borrower and against or with respect to the
     Collateral, whether or not suit is instituted by or against the Lender.

     19. The Borrower hereby waives presentment, demand, notice of maturity,
     dishonor, protest and notice of protest, and also waives any delay on the
     part of the Lender. The Borrower assents to any extension or other
     indulgence (including, without limitation, the release or substitution of
     collateral) permitted by the Lender with respect to this Note and the
     Collateral.

     20. This Note shall be binding upon the Borrower and the Borrower's
     respective heirs, executors, administrators, successors, assigns and
     representatives, and shall inure to the benefit of the Lender and its
     successors, endorsees and assigns.

     21.  The captions in this Note are for convenience only and do not
     constitute part of this instrument.


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     22. The Borrower represents and warrants to the Lender that he or she has
     the full power and authority to execute the Note and that this Note
     constitutes a valid, binding and enforceable obligation of the Borrower.

     23. Upon any transfer or assignment of this Note by the Lender, the
     Collateral held under this Note at the time of transfer or assignment may
     be delivered to the assignee or transferee, who shall thereupon become
     vested with all the rights and powers given to the Lender herein.

     24. This Note shall be governed by the laws of the State of Maryland,
     excluding its conflicts of laws, principles, and courts sitting in the
     State of Maryland shall provide the exclusive forum for the resolution of
     any disputes hereunder.











WITNESS the following signatures.

                                           /s/ RICHARD J. MASSEY
                                           -----------------------------
                                           Signature of Borrower

                                           Printed Name and Address of Borrower:

                                           RICHARD J. MASSEY
                                           -------------------------------------
                                           16020 INDUSTRIAL DRIVE
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                                           GAITHERSBURG, MD  20877
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