EX-10.40



 Exhibit 10.40 

MANUFACTURING AND SUPPLY AGREEMENT – AMENDMENT No. 2 

THIS AGREEMENT is made the 25th day of October 2013 

BETWEEN: 
  

	(1)	 HORIZON PHARMA AG a company incorporated in accordance with the laws of Switzerland with its registered office
at Kägenstrasse 17, CH-4153 Reinach, Switzerland (“Horizon”); and 


  

	(2)	 MUNDIPHARMA MEDICAL COMPANY a partnership organised in accordance with the laws
of Bermuda with Registered No. EC – 16260 and with its registered office at Canon’s Court, 22 Victoria Street, Hamilton, HM 12 Bermuda (“Mundipharma”). 



RECITALS 
  

	(A)	 The Principal and Distributor concluded a Manufacturing and Supply Agreement (“MSA”) on November 4, 2010 to have Horizon procure the
manufacture of the Products and supply the same and have designated Mundipharma to purchase the Products from Horizon for distribution in accordance with the Exclusive Distribution Agreement (“EDA”) between Horizon and MICL concluded on
November 4, 2010 and amended on March 5, 2012. 


  

	(B)	 The Principal and Distributor wish to amend the MSA to include additional territories. 



  
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 NOW IT IS HEREBY AGREED as follows: 

 

	1.	 DEFINITIONS AND INTERPRETATION 


  

	1.1	 As used in this Agreement, capitalized words and expressions shall have the meanings defined in the MSA, provided that the following words and
phrases shall have the following meanings: In this Agreement, the following terms shall have the following meanings: 


  

			
	 “AMENDMENT”
	  	 means this Agreement between the Parties as set out and described herein.


  

	1.2	 Any reference in this AMENDMENT to “writing” or cognate expressions includes a reference to facsimile transmission.



  

	1.3	 The headings in this AMENDMENT are for convenience only and shall not affect its interpretation. 



 

	1.4	 References to “persons” includes individuals, bodies corporate (wherever incorporated), unincorporated associations and partnerships.



  

	1.5	 Any reference to an enactment or statutory provision is a reference to it as it may have been, or may from time to time be amended, modified,
consolidated or re-enacted. 


  

	2.	 AMENDMENTS TO THE MSA 


  

	2.1	 Schedule 1 of the MSA is amended to add the following additional countries: 



“Algeria, Angola, Bahrain, Benin, Botswana, Burkina Faso, Burundi, Cameroon, Central African Republic, Congo, Cote
D’Ivoire, Democratic Republic of the Congo, Djibouti, Egypt, Equitorial Guinia, Eritria, Ethiopia, Gabon, Ghana, Guinia, Iran, Iraq, Jordan, Kenya, Kuwait, Lebanon, Lesotho, Libya, Madagascar, Malawi, Mali, Mauritius, Morocco, Mozambique,
Namibia, Nigeria, Oman, Qatar, Rwanda, Saudi Arabia, Senegal, Seychelles, Sierra Leone, Somalia, , South Sudan, Sudan, Swaziland, Tanzania, Togo, Tunisia, U.A.E, Uganda, Yemen, Zambia, Zimbabwe” 

  
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 In WITNESS WHEREOF the PARTIES hereto have caused this AMENDMENT to be executed in duplicate by
their duly authorized officers as of the Commencement Date. 
  

											
	HORIZON PHARMA AG	 	 	 	MUNDIPHARMA MEDICAL COMPANY
	 			 		 
	By:	 	/s/ Robert W. Metz	 		 	By:	 	/s/ Douglas Docherty	 	 
	Name:	 	Robert W. Metz	 		 	Name:	 	Douglas Docherty	 	 
	Title:	 	SVP Business Ops	 		 	Title:	 	General Manager	 	 
	 	 	 	 	 	 	 	 	 	 	 
	HORIZON PHARMA AG	 		 		 		 	 
	 			 		 
	By:	 	/s/ Timothy P. Walbert	 		 		 		 	 
	Name:	 	Timothy P. Walbert	 		 		 		 	 
	Title:	 	Chairman, President and CEO	 		 		 		 	 
	 	 	 	 	 	 	 	 	 	 	 

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