### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 1 of 21

**UNITED STATES ENVIRONMENTAL PROTECTION AGENCY**

**WASHINGTON, D.C. 20460**

**OFFICE OF CHEMICAL SAFETY AND**

**POLLUTION PREVENTION**

**MEMORANDUM D**  **ATE :**  04/14/2014 **SUBJECT: Trifloxystrobin.**  Acute and Chronic Aggregate Dietary (Foo d and Drinking

Water) Exposure and Risk Assessment s for Uses on Dry Peas, Chickpeas, and Lentils. **PC Code:** 129112 **DP Barcode:** D 413712 **Decision No.:** 4 78982 **Registration No. :**  264 - 1055 **Petition No.:** 3F8180 **Regulatory Action:** Section 3 Registration **Risk As sessment Type:**  Single Chemical/Aggregate **Case No.:** NA T **XR No.:** NA **CAS No.:** 141517 - 21 - 7 **MRID No.:** NA **40 CFR:** 180.555 

## FROM: Meheret Negussie , Chemist

Risk Assessment Branch III (RAB3) Health Effects Division ( HED; 7509P) **THROUGH:** William Cutchin, Chem ist

Id eliz Negrón - Encarnaci ó n, Ph. D. Chemist Dietary Exposure Science Advisory Council (DESAC) and Christine Olinger , Branch Chief RAB3 /HED (7509P) **TO:** Nancy

Tsaur, Chemist/Risk Assessor RAB3/HED (7509P) and Tony Kish, RM 22 Fungicide Branch Registration Division (7505P)

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 2 of 21 **Executive Summary** Acute and Chronic aggregate dietary (food and drinking water) exposure and risk assessment s w ere conducted using the Dietary Exposure Evaluation Model software with the Food Commodity

Intake Datab ase (DEEM - FCID) Version 3.16. This software uses 2003 - 2008 food consumption data from the U.S. Department of Agriculture’s (USDA’s) National Health and Nutrition Examination Survey , What We Eat in America, (NHANES/WWEIA). The anal ys es were conducted in s upport of a human health risk assessment for the proposed Section 3 requests on dry p eas, c hickpeas, and l entils. T his memorandum was reviewed b y two peer reviewers of the DESAC, per DESAC SOP 2012.1. Acute Dietary

Results and Characterization There were no appropriate toxicological effects attributable to a single exposure (dose) for the general population; therefore, a dose and endpoint were not identified. An acute endpoint was identified for females 13 - 49 years old. Therefore, an acute dietary assessment was conducted for this population subgroup. An acute dietary

assessment was conducted assuming tolerance level residues and 100% crop treated (%CT) . DEEM version 7.81 default processing factors were assumed except for where tolerances were est ablished for processed commodities . For the dietary assessment, a value of 0.20 ppm was added for the metabolite L7a in addition to the recommended tolerance level for liver. The acute drinking water estimate of 427 μg/L , provided b y the Environmental F ate and Effects Division (EFED) was directl y incorporated into the acute assessment. The results of the acute dietary (food and drinking water) anal ys is indicate that exposure and risk does not exceed HED’s level of concern (LOC) for females 13 - 49 years ol d . The dietary exposure for food and water at the 95 th 

## percentile of exposure distribution is estimated at 1% of the a cute Population Adjusted Dose ( aPAD) for the females 13 - 49 years old . Chronic Dietary

Results and Characterization A chronic dietary

as sessment was conducted assumi ng tolerance level residues for all commodities except grapes, apples, oranges, and pears which used anticipated residues (ARs) . For the dietary

assessment, a value of 0.20 ppm was added to account for the Metabolite L7a in ad dition to the recommended tolerance level for liver. For all crops , it was assumed that 100% CT was treated . DEEM version 7.81 default processing factors were assumed except for where tolerances were established for processed commodities . The chronic dri nking water estimate of 365 μg/L, provided by EFED was directly

incorporated into the chronic assessment. The results of the chronic dietary (food and drinking water) anal ys is indicate that exposure and risk does not exceed HED’s LOC for the U.S. populati on and all population subgroups. The dietary exposure for food and water is estimated at 32 % of the c hronic Population Adjusted Dose (cPAD) for the general U.S. population and 78% for all infants, the most highl y exposed population subgroup . Drinking wate r is the major contributor to the chronic dietary assessment.

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 3 of 21 Cancer Dietary

Exposure The Cancer Assessment Review Committee (CARC) classified zoxamide as “ n ot likely to be carcinogenic to humans ; ” therefore, a cancer assessment was not performed. **I. Introduction**  Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result i n no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to point of departure (POD, NOAEL , LOAEL, e.g.) divided by the required uncertainty

or safety factors. For acute and non - can cer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. HED is generall y concerned when estimated cancer risk exceeds one in one million. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21 - JUN - 2000, web link: http://www.epa.gov/fedrgstr/EPA PEST/2000/July

/Day- 12/6061.pdf ; or see SOP 99.6 (20 - AUG - 1999). The most recent dietary

risk assessment for trifloxy strobin was conducted by Nancy Tsaur (DP# 3 87201 , 0 7 / 13 /201 1 ). **II. Residue Information**  Tolerances: Permanent tolerances for residu es of trifloxystrobin are listed in 40 CFR §180.555 and are expressed in terms of combined residues of triflox ys trobin and the free form of its acid metabolite CGA - 321113, in or on a variety of plant commodities. Residue of Concern : HED has concluded th at both trifloxystrobin and CGA - 321113 are of concern for both regulatory and risk assessment purposes in both plant and livestock commodities (DP# 257835, F. Ives, 0 7/13/1999). HED also determined that for livestock commodities, the metabolite L 7a (taurin e conjugate of trifloxy strobin) in liver should be included in the risk assessment. Drinking water estimates used in this memo include combined residues of parent and the major metabolite CGA - 321113. The USDA Pesticide Data Program (PDP) monitored pestic ide residues in catfish in 2008, 2009, and 2010. In general, pesticide residues would not be expected to be found in fish unless the pesticide bioaccumulates or has an aquatic use. To determine whether or not residues are present in fish, HED now routine ly checks PDP monitoring data regardless of the pesticide’s uses and phy sicochemical properties. In 200 8 , PDP anal yz ed 552 samples of catfish for triflox ys trobin residues. None of the samples contained detectable residues. As a result, residues in fish were not included in the assessment. For the proposed new uses for dry peas, chickpeas, an d lentils, the recommended tolerances are presented in Table 1 ( DP# D4 13711 , M. Negussie, 0 4 / 1 4 /2014 ).

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 4 of 21 **Table 1**  **. Tolerance Summary for Trifloxystrobin.**  Commodity Proposed Tolerance (ppm) Recommended

Tolerance (ppm) Comments; Correct Commodity Definition Pea, dry, seed 0.06 0.06 

## Residue Data used for Acut e and Chronic Assessments : The acute assessment was based on the assumption of tolerance level residues fo r all commodities while the chronic assessment incorporated some ARs . B oth assessments assumed 100 %CT. For the dietary assessments, a value of 0.20 ppm was added for the Metabolite L7a in addition to the recommended tolerance level for liver; therefore, meat by products and liver of cattle, goats, horses, and sheep were assessed in the dietary assessments at 0.3 ppm. The maximum theoretical dietary burden was lower for pork, except for pork liver, than for these other commodities. Therefore, pork was in cluded in the DEEM at the established tolerance level of 0.05 ppm; pork, liv er was included at 0.16 ppm (DP# D267787, L . Cheng, 0 1/17/2002). A separate tolerance was set for grape, raisin; therefore, the processing factor for this commodity was set at 1. For all other processed commodities, DEEM 7.81 default processing factors were used. Residue reduction data on strawberries from a single trial were previously provided which demonstrated that residues of triflox ys trobin and CGA - 321113 declined in/on str awberries after washing and cooking . T he default proc essing factor of 1 was retained since the exposure estimates are below HED’s LOC. The chronic dietary

assessment was refined by using ARs for apple, grape, orange , and pear commodities (see Table 2 ). ARs were provided by ARIA (email, D. Rate, 09/11/2007) and calculated b y averaging the residue values of over the entire field trial and using the LOQ for non - detect samples. **Table 2**  **. Calculated A**  **nticipated R**  **esidue s for Use in Trifloxystrobin Chronic Diet**  **ary Analysis .**  **Comm odity**  **Field Trial Average** a 

### ppm **Recommended A nticipated**  **R esidue to U**  **se in DEEM** ppm Grape 0.374875 0.4 Apple 0.187285 0.2 Orange 0.12052 0.15 Pear 0.1 68 0.2 a 

### non - detect = LOQ 

## III. **Percent Crop Treated Information** 100% CT was as sumed for all crops.

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 5 of 21 **IV. Drinking Water Data**  The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) and incorporated directly into this dietary assessment (DP# 413801 , M. Biscoe, 01/28/2014 ). Water residues were incorporated in the DEEM - FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.” The currently

registered turf use continues to have the highest annual use rate (1.33 lb a.i. /acre) of all the proposed and existing uses of triflox ys trobin . Maximum s urface water and groundwater EDWCs for turf using PRZM/EXAMS ( Pesticide Root Zone Model)/ ( Exposure Anal ys is Modeling Sy stem) and ground water EDWC s using the PRZM - GW (ground water) model are reported in Table 3. The Tier I PRZM - GW EDWCs for trifloxystrobin total toxic residues are greater than the surface water EDWCs. The highest estimated peak (acute) concentration of total toxic residues in groundwater is 427 μg/L , and the highest estimated (chronic) concentration in groundwater is 365 μg/L. **Table 3. Maxim**  **um E**  **stimated D**  **rinking W**  **ater C**  **oncentrations (EDWCs) of T**  **otal T**  **oxic R**  **esidues of**  **Trifloxystrobin. Drinking water**  **source (m**  **odel) Model Scenario &** 

**Application Method Acute**  **Chronic Cancer**  Units: μ/L Surface Water 1 

### (PRZM - EXAMS) Pennsylvania Turf scenario Aerial Application Peak 1 - in - 10 Year Chronic

1 - in - 10 Year 30 - year Annual

Average 29 ppb 23 ppb 19 ppb Groundwater (PRZM - GW 30 - year simulation) Wisconsin Corn scenario Ground Application Peak Post - Breakthrough Average **427 ppb** 2 

### 365 ppb 2 1 

### Drinking Water Assessment for Tolerance Petition for New Uses of Trifloxystrobin in Trifloxystrobin Flowable Fungicide [EPA Reg. No. 264 - 989]. D378919 2 

### The highest estimated concentration is bolded. 

## V. **DEEM -**  **FCID Program and Consumption Information** Triflox ys trobin acute and chronic dietary exposure assessment s were conducted using the DEEM - FCID, Version 3.16, which i ncorporates 2003 - 2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointly

by USDA/ARS and EPA. For chronic exposure assessment, consumption data ar e averaged for the entire U.S. population and within population subgroups. However, for acute exposure assessment, consumption data are retained as individual consumption events. Based on anal ys is of the 2003 - 2008 WWEIA consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 6 of 21 following population subgroups: the general U.S. population, all infants (<1 year old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19 , adults 20 - 49, females 13 - 49, and adults 50 - 99 ye ars old. For chronic dietary

exposure assessment, an estimate of the residue level in each food or food form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average d ail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list t o arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup. **VI. Toxicological Information**  HED previousl y evaluated the toxico logy data base for trifloxy strobin, established Reference Doses (RfDs), and selected the toxicological endpoints for dietary exposure risk assessments. No acute dietary

endpoint was identified for the general population or other population subgroup aside from females 13 - 49 (i.e . females of childbearing age). The FQPA SF was reduced to 1X based on toxicological considerations by the FQPA SF Committee (HED Doc. No. 013545, B. Tarplee, 0 1/ 0 7/1999). The doses relevant to dietary exposure are summarized in Ta ble 4 . **Table 4**  **. Summary of Toxicological Doses and Endpoints for**  **Trifloxystrobin for Use in Dietary Risk** 

**Assessments .**  **Exposure/ Scenario**  **Dose Used in Risk**

**Assessment/ UF**  **Hazard and Exposure Based Special FQPA Safety** 

**Factor** 

### Study and Toxicological Effects Ac ute Dietary ( Females 13 - 49 only) NOAEL = 250

mg/kg/day UF = 100 X Ac ute RfD = 2.5 mg/kg/day FQPA SF=1X aPAD = aRfD ÷ FQPA S F

= 2.5 mg/kg/day Developmental Toxicity - Rat LOAEL = 500 mg/kg/day, based upon increased fetal skeletal anomalies.

Ac ute Diet ary ( General Population including infants and children) There were no appropriate toxicological effects attributable to a single exposure (dose)

observed in oral toxicity studies including maternal effects in developmental studies in rats and rabbits. The refore, a dose and endpoint were not identified for this risk assessment. Chronic Dietary (All Populations) Parental

NOAEL= 3.8 mg/kg/day UF = 100 X Chronic RfD = 0.0 38 mg/kg/day FQPA SF=1X cPAD = cRfD ÷ FQPA SF = 0.0 38 mg/kg/day Two - Generation reproduction study - Rat LOAEL = 55.3 mg/kg/day, based upon decreases in body weight, body weight gains, reduced food consumption and histopathological lesions in the liver, kidneys and spleen. Cancer (oral, dermal, inhalation) Trifloxystrobin is classified as “N ot Likely Human Carcinogen” based on the lack of

evidence of carcinogenicity in mouse and rat cancer studies.

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 7 of 21 NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. FQPA SF = FQPA Safety Fact or. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. N/A = not applicable. 

## VII. **Results/Discussion** As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM - FCID anal ys es estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 5 are for the general U.S. Population, all infants (<1 year old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, f emales 13 - 49, adults 20 - 49, and adults 50 - 99 years. Results of Acute Dietary

(Food and Drinking Water) Exposure Anal ys is The results of the acute dietary (food and drinking water) anal ys is indicate that exposure and risk does not exceed HED’s LOC for fem ales 13 - 49 y ears old . The dietary exposure for food and water at the 95 th 

## percentile of exposure distribution is estimated at 1% of the aPAD for females 13 - 49 years old . Results of Chronic Dietary (Food and Drinking Water) Exposure Analy sis The results of the chronic dietary (food and drinking water) anal ys is indicate that exposure and risk does not exceed HED’s LOC for the U.S. population and all population subgroups. The dietary exposure for food and water is estimated at 32 % of the cPAD for the general U.S. population and 78% for all infants, the most highly exposed population subgroup . Drinking water is the major contributor to the dietary assessment. The dietary exposure for food only was estimated at 2 6 % for all infants, the most highly exposed p opulation subgroup . **Table 5**  **. Summary of Dietary**  **(Food and Drinking Water) Exposure and Risk for Trifloxystrobin.**  **1** 

### Population Subgroup **Acute Dietary (95th Percentile)**  **Chronic Dietary Dietary**  **Exposure mg/kg/day**  **% aPAD Dietary**  **Exposure mg/kg/day**  **% cPAD** General U.S. Population

NA 2 

### 0.01 2139 3 2 **All Infants (< 1 year old) 0.029751**  **78** Children 1 - 2 years old 0.02 6545 70 Children 3 - 5 years old 0.02 0 721 5 4 Children 6 - 12 years old 0.01 2755 3 4 Youth 13 - 19 years old 0.0 08879 2 3 Adults 20 - 49 years old 0.01 1282 3 0

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 8 of 21 **Table 5**  **. Summary of Dietary**  **(Food and Drinking Water) Exposure and Risk for Trifloxystrobin.**  **1** 

### Population Subgroup **Acute Dietary (95th Percentile)**  **Chronic Dietary Dietary**  **Exposure mg/kg/day**  **% aPAD Dietary**  **Exposure mg/kg/day**  **% cPAD** Adults 50 - 99 years old 0.01 08 70 29 Females 13 - 49 years old **0.0 32259**  **1. 3**  0.01 0893 29 1 

### Values for the population with the highest risk for each type of risk assessment are **bolded** . 2 

### NA = Not Applicable; no acute dietary endpoint was identi fied for these population subgroups . 3 

### The highest estimated concentration is bolded. 

## VIII. **Characterization of Inputs/Outputs** The dietary

exposure and risk estimates are highl y conservative since they assume tolerance level residues, anticipated resi dues for some crops, 100 %CT, and include mainly default processing factors. Additional refinements may be implemented such as the use of additional AR s , incorporation of %CT data, inclusion of empirical processing factor s, and/or monitoring data that better reflect residu es at the time of consumption. D rinking water is the major contributor to the dietary

assessment . Since risk estimates are below HED’s level of concern, a more highl y refined analysis is not needed at this time. **IX. Conclusions**  Based on the conservative assumptions noted above, acute and chronic dietary risk estimates for trifloxystrobin do not exceed HED’s level of concern for the general U.S. population, or any of the population subgroups, including infants and children. T he exposur e estimates are likel y to overestimate an y actual dietary exposures to trifloxystrobin . **X. List of Attachments**  1. Acute Food P lus Water Residue Input File 2. Acute Results File 3. Chronic Food P lus Water Residue Input File 4. Chronic Results File 5. Chronic Food Onl y Results File

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 9 of 21 **Attachment 1: Acute Food plus Water Residue Input File**  Filename: C: \ Users \ mnegussi \ Documents \ DEEM Version 3.16 \ Trifloxystrobin \ ACUTE_FoodWater2013.R08 Chemical: Trifloxystrobin RfD(Chronic): .038 mg/kg bw/day NOEL(Chronic): 3.8 mg /kg bw/day RfD(Acute): 2.5 mg/kg bw/day NOEL(Acute): 250 mg/kg bw/day Date created/last modified: 05 - 20 - 2014/15:22:05 Program ver. 3.16, 03 - 08 - d Comment: PP#0E7789 (Acute Dietary for Females 13 - 49 Only)

--------------------------------------------- -------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- --------- - ------ ------ ------- 0101050000 1AB Beet, garden, roots 0.100000 1.000 1.000 0101050001 1AB Beet, garden, roots - babyfood 0.100000 1.000 1.000 0101052000 1A Beet, sugar 0.100000 1.000 1.000 0101052001 1A Beet, sugar - babyfood 0.100000 1.000 1.000 0101053000 1A Beet, sugar, molasses 0.200000 1.000 1.000 0101053001 1A Beet, sugar, molasses - babyfood 0.200000 1.000 1.000 0101067000 1AB Burdock 0.100000 1.000 1.000 0101078000 1AB Carrot 0.100000 1.000 1.000 0101078001 1AB Carrot - babyfood 0.100000 1.000 1.000 0101079000 1AB Carrot, juice 0.100000 1.000 1.000 0101084000 1AB Celeriac 0.100000 1.000 1.000 0101100000 1AB Chicory, roots 0.100000 1.000 1.000 0101168000 1AB Ginseng, dried 0.100000 1.000 1.000 0101190000 1AB Horseradish 0.100000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.100000 1.000 1.000 0101251000 1AB Parsnip 0.100000 1.000 1.000 0101251001 1AB Parsni p - babyfood 0.100000 1.000 1.000 0101314000 1AB Radish, roots 0.100000 1.000 1.000 6E7088 0101316000 1AB Radish, Oriental, roots 0.100000 1.000 1.000 6E7088 0101327000 1AB Rutabaga 0.100000 1.000 1.000 0101331000 1AB Salsify, roots 0.100000 1.000 1.000 0101388000 1AB Turnip, roots 0.100000 1.000 1.000 0103296000 1C Potato, chips 0.040000 1.000 1.000 8F7464 0103297000 1C Potato, dry (granules/ flakes) 0.040000 6.500 1.000 8F7464 0103297001 1C Potato, dry (granules/ flakes) - b 0.040000 6.500 1.000 8F7464 0103298000 1C Potato, flour 0.040000 6.500 1.000 8F7464 0103298001 1C Potato, flour - babyfood 0.040000 6.500 1.000 8F7464 0103299000 1C Potato, tuber, w/peel 0.040000 1.000 1.000 8F7464 0103299001 1C Potato, tuber, w/peel - babyfood 0.040000 1.000 1.000 8F7464 0103300000 1C Potato, tuber, w/o peel 0.040000 1.000 1.000 8F7464 0103300001 1C Potato, tuber, w/o peel - babyfood 0.040000 1.000 1.000 8F7464 0200051000 2 Beet, garden, tops 4.000000 1.000 1.000 0200 315000 2 Radish, tops 10.000000 1.000 1.000 6E7088 0200317000 2 Radish, Oriental, tops 10.000000 1.000 1.000 6E7088 0402076000 4B Cardoon 3.500000 1.000 1.000 8F7464 0402085000 4B Celery 3.500000 1.000 1.000 8F7464 0402085001 4B Celery - babyfood 3.500000 1.000 1.000 8F7464 0402086000 4B Celery, juice 3.500000 1.000 1.000 8F7464 0402087000 4B Ce ltuce 3.500000 1.000 1.000 8F7464 0402152000 4B Fennel, Florence 3.500000 1.000 1.000 8F7464 0402322000 4B Rhubarb 3.500000 1.000 1.000 8F7464 0402367000 4B Swiss cha rd 3.500000 1.000 1.000 8F7464 0600347000 6 Soybean, seed 0.080000 1.000 1.000 5F6956 0600349000 6 Soybean, soy milk 0.080000 1.000 1.000 5F6956 0600349001 6 Soybean, soy mil k - babyfood or in 0.080000 1.000 1.000 5F6956 0600350000 6 Soybean, oil 0.080000 1.000 1.000 5F6956 0600350001 6 Soybean, oil - babyfood 0.080000 1.000 1.000 5F6956 0601349500 6AB Soybean, vegetable 0.080000 1.000 1.000 0603098000 6C Chickpea, seed 0.060000 1.000 1.000 0603098001 6C Chickpea, seed - babyfood 0.060000 1.000 1.000 0603099000 6C Chickpea, flour 0.060000 1. 000 1.000 3F8180

Full comment: 3F8180 DP# 413711 0603203000 6C Lentil, seed 0.060000 1.000 1.000 3F8180

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 10 of 21

Full comment: 3F8180 DP# 413711 0603256000 6C Pea, dry 0.060000 1.00 0 1.000 3F8180

Full comment: 3F8180 DP# 413711 0603256001 6C Pea, dry - babyfood 0.060000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.060000 1.000 1.000 3F8180

Full comment: 3F8180 DP # 413711 0603348000 6C Soybean, flour 0.080000 1.000 1.000 5F6956 0603348001 6C Soybean, flour - babyfood 0.080000 1.000 1.000 5F6956 0801374000 8A Tomatillo 0.500000 1.000 1.000 0801 375000 8A Tomato 0.500000 1.000 1.000 0801375001 8A Tomato - babyfood 0.500000 1.000 1.000 0801376000 8A Tomato, paste 0.500000 5.400 1.000 0801376001 8A Tomato, paste - babyfood 0.500000 5.400 1.000 0801377000 8A Tomato, puree 0.500000 3.300 1.000 0801377001 8A Tomato, puree - babyfood 0.500000 3.300 1.000 0801378000 8A Tomato, dried 0.5 00000 14.300 1.000 0801378001 8A Tomato, dried - babyfood 0.500000 14.300 1.000 0801379000 8A Tomato, juice 0.500000 1.500 1.000 0801380000 8A Tomato, Tree 0.500000 1.000 1.000 08 02148000 8BC Eggplant 0.500000 1.000 1.000 0802234000 8BC Okra 0.500000 1.000 1.000 8F7464 0802270000 8B Pepper, bell 0.500000 1.000 1.000 0802270001 8B Peppe r, bell - babyfood 0.500000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.500000 1.000 1.000 0802271001 8B Pepper, bell, dried - babyfood 0.500000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.500000 1.000 1.000 0802272001 8BC Pepper, nonbell - babyfood 0.500000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.500000 1.000 1.000 0901075000 9A Cantaloupe 0.500000 1.000 1. 000 0901187000 9A Honeydew melon 0.500000 1.000 1.000 0901399000 9A Watermelon 0.500000 1.000 1.000 0901400000 9A Watermelon, juice 0.500000 1.000 1.000 0902021000 9B Bal sam pear 0.500000 1.000 1.000 0902088000 9B Chayote, fruit 0.500000 1.000 1.000 0902102000 9B Chinese waxgourd 0.500000 1.000 1.000 0902135000 9B Cucumber 0.500000 1.000 1.000 0902308000 9B Pumpkin 0.500000 1.000 1.000 0902309000 9B Pumpkin, seed 0.500000 1.000 1.000 0902356000 9B Squash, summer 0.500000 1.000 1.000 0902356001 9B Squash, summer - babyfood 0.500000 1.000 1.000 0902357000 9B Squash, winter 0.500000 1.000 1.000 0902357001 9B Squash, winter - babyfood 0.500000 1.000 1.000 1001106000 10A C itron 0.600000 1.000 1.000 0F6121 1001107000 10A Citrus hybrids 0.600000 1.000 1.000 0F6121 1001108000 10A Citrus, oil 38.000000 1.000 1.000 0F6121 1001240000 10A Orange 0.600000 1.000 1.000 0F6121 1001241000 10A Orange, juice 0.600000 1.800 1.000 0F6121 1001241001 10A Orange, juice - babyfood 0.600000 1.800 1.000 0F6121 1001242000 10A Orange, peel 0.600000 1.000 1.000 0F6121 1001369000 10A Tangerine 0.600000 1.000 1.000 0F6121 1001370000 10A Tangerine, juice 0.600000 2.300 1.000 0F6121 1002197000 10B Kumquat 0.600000 1.000 1.000 1002199000 10B Lemon 0.600000 1.000 1.000 0F6121 1002200000 10B Lemon, juice 0.600000 2.000 1.000 0F6121 1002200001 10B Lemon, juice - babyfood 0.600000 2.000 1.000 0F6121 1002201000 10B Lemon, peel 0.600000 1.000 1.000 0F6121 1002206000 10B Lime 0.600000 1.000 1.000 0F6121 1002207000 10B Lime, juice 0.60000 0 2.000 1.000 0F6121 1002207001 10B Lime, juice - babyfood 0.600000 2.000 1.000 0F6121 1003180000 10C Grapefruit 0.600000 1.000 1.000 0F6121 1003181000 10C Grapefruit, juice 0.600000 2.1 00 1.000 0F6121 1003307000 10C Pummelo 0.600000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.500000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.500000 1.000 1.000 1100008 001 11 Apple, peeled fruit - babyfood 0.500000 1.000 1.000 1100009000 11 Apple, dried 0.500000 8.000 1.000 1100009001 11 Apple, dried - babyfood 0.500000 8.000 1.000

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 11 of 21 1100010000 11 Apple, juice 0.500000 1.300 1.000 1100010001 11 Apple, juice - babyfood 0.500000 1.300 1.000 1100011000 11 Apple, sauce 0.500000 1.000 1.000 1100011001 11 Apple, sauce - babyfood 0.5000 00 1.000 1.000 1100129000 11 Crabapple 0.500000 1.000 1.000 1100173500 11 Goji berry 0.500000 1.000 1.000 1100210000 11 Loquat 0.500000 1.000 1.000 11002 66000 11 Pear 0.500000 1.000 1.000 1100266001 11 Pear - babyfood 0.500000 1.000 1.000 1100267000 11 Pear, dried 0.500000 6.250 1.000 1100268000 11 Pear, juice 0.500000 1.000 1.000 1100268001 11 Pear, juice - babyfood 0.500000 1.000 1.000 1100310000 11 Quince 0.500000 1.000 1.000 1201090000 12A Cherry 2.00 0000 1.000 1.000 0F6121 1201090001 12A Cherry - babyfood 2.000000 1.000 1.000 0F6121 1201091000 12A Cherry, juice 2.000000 1.500 1.000 0F6121 1201091001 12A Cherry, juice - babyfood 2.000000 1.500 1.000 0F6121 1202012000 12B Apricot 2.000000 1.000 1.000 0F6121 1202012001 12B Apricot - babyfood 2.000000 1.000 1.000 0F6121 1202013000 12B Apricot, dried 2.000000 6.000 1.000 0F6121 1202014000 12B Apricot, juice 2.000000 1.000 1.000 0F6121 1202014001 12B Apricot, juice - babyfood 2.000000 1.000 1.000 0F6121 1202230000 12B Nectarine 2.000000 1.000 1.000 0F6121 1202260000 12B Peach 2.000000 1.000 1.000 0F6121 1202260001 12B Peach - babyfood 2.000000 1.000 1.000 0F6121 1202261000 12B Peach, dried 2.000000 7.000 1.000 0F6121 1202261001 12B Peach, dried - babyfood 2.000000 7.000 1.000 0F6121 1202262000 12B Peach, juice 2.000000 1.000 1.000 1202262001 12B Peach, juice - babyfood 2.000000 1.000 1.000 1203285000 12C Plu m 2.000000 1.000 1.000 0F6121 1203285001 12C Plum - babyfood 2.000000 1.000 1.000 0F6121 1203286000 12C Plum, prune, fresh 2.000000 1.000 1.000 0F6121 1203286001 12C Plum, prun e, fresh - babyfood 2.000000 1.000 1.000 0F6121 1203287000 12C Plum, prune, dried 2.000000 5.000 1.000 0F6121 1203287001 12C Plum, prune, dried - babyfood 2.000000 5.000 1.000 0F6121 1203288000 12C Plum, prune, juic e 2.000000 1.400 1.000 0F6121 1203288001 12C Plum, prune, juice - babyfood 2.000000 1.400 1.000 0F6121 1304175000 13D Grape 2.000000 1.000 1.000 1304176000 13D Grape, juice 2.000000 1.200 1.000 1304176001 13D Grape, juice - babyfood 2.000000 1.200 1.000 1304179000 13D Grape, wine and sherry 2.000000 1.000 1.000 1307359000 13G Strawberry 1.100000 1.000 1. 000 8F7464 1307359001 13G Strawberry - babyfood 1.100000 1.000 1.000 8F7464 1307360000 13G Strawberry, juice 1.100000 1.000 1.000 8F7464 1307360001 13G Strawberry, juice - babyfood 1.100000 1.000 1.000 8F 7464 1400003000 14 Almond 0.040000 1.000 1.000 1400003001 14 Almond - babyfood 0.040000 1.000 1.000 1400004000 14 Almond, oil 0.040000 1.000 1.000 1400004001 14 Almo nd, oil - babyfood 0.040000 1.000 1.000 1400059000 14 Brazil nut 0.040000 1.000 1.000 0F6121 1400068000 14 Butternut 0.040000 1.000 1.000 1400081000 14 Cashew 0.040000 1.000 1.000 0F6121 1400092000 14 Chestnut 0.040000 1.000 1.000 0F6121 1400155000 14 Hazelnut 0.040000 1.000 1.000 0F6121 1400156000 14 Hazelnut, oil 0.040000 1.000 1.000 1400185000 14 Hickory nut 0.040000 1.000 1.000 1400213000 14 Macadamia nut 0.040000 1.000 1.000 0F6121 1400269000 14 Pecan 0.040000 1.0 00 1.000 0F6121 1400278000 14 Pine nut 0.040000 1.000 1.000 1400282000 14 Pistachio 0.040000 1.000 1.000 0F6121 1400391000 14 Walnut 0.040000 1.000 1.000 0F 6121 1500025000 15 Barley, pearled barley 0.050000 1.000 1.000 1500025001 15 Barley, pearled barley - babyfood 0.050000 1.000 1.000 1500026000 15 Barley, flour 0.050000 1.000 1.000 1500026001 15 Barl ey, flour - babyfood 0.050000 1.000 1.000 1500027000 15 Barley, bran 0.050000 1.000 1.000 1500065000 15 Buckwheat 0.050000 1.000 1.000

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 12 of 21 1500066000 15 Buckwheat, flour 0.050000 1.000 1.000 1500120000 15 Corn, field, flour 0.050000 1.000 1.000 0F6121 1500120001 15 Corn, field, flour - babyfood 0.050000 1.000 1.000 0F6121 1500121000 15 Corn, field, meal 0.05000 0 1.000 1.000 0F6121 1500121001 15 Corn, field, meal - babyfood 0.050000 1.000 1.000 0F6121 1500122000 15 Corn, field, bran 0.050000 1.000 1.000 0F6121 1500123000 15 Corn, field, starch 0.050000 1.0 00 1.000 0F6121 1500123001 15 Corn, field, starch - babyfood 0.050000 1.000 1.000 0F6121 1500124000 15 Corn, field, syrup 0.050000 1.500 1.000 0F6121 1500124001 15 Corn, field, syrup - babyfood 0.050000 1.500 1.0 00 0F6121 1500125000 15 Corn, field, oil 0.100000 1.000 1.000 0F6121 1500125001 15 Corn, field, oil - babyfood 0.100000 1.000 1.000 0F6121 1500126000 15 Corn, pop 0.050000 1.000 1.000 0F6 121 1500127000 15 Corn, sweet 0.040000 1.000 1.000 1500127001 15 Corn, sweet - babyfood 0.040000 1.000 1.000 1500231000 15 Oat, bran 0.050000 1.000 1.000 1500232000 15 Oat, flour 0.050000 1.000 1.000 1500232001 15 Oat, flour - babyfood 0.050000 1.000 1.000 1500233000 15 Oat, groats/rolled oats 0.050000 1.000 1.000 1500233001 15 Oat, groats/rolled oats - babyfo od 0.050000 1.000 1.000 1500323000 15 Rice, white 3.500000 1.000 1.000 0F6121 1500323001 15 Rice, white - babyfood 3.500000 1.000 1.000 0F6121 1500324000 15 Rice, brown 3.500000 1.000 1.000 0F6121 1500324001 15 Rice, brown - babyfood 3.500000 1.000 1.000 0F6121 1500325000 15 Rice, flour 3.500000 1.000 1.000 0F6121 1500325001 15 Rice, flour - babyfood 3.500000 1.00 0 1.000 0F6121 1500326000 15 Rice, bran 3.500000 1.000 1.000 0F6121 1500326001 15 Rice, bran - babyfood 3.500000 1.000 1.000 0F6121 1500381000 15 Triticale, flour 0.050000 1.000 1.00 0 1500381001 15 Triticale, flour - babyfood 0.050000 1.000 1.000 1500401000 15 Wheat, grain 0.050000 1.000 1.000 1500401001 15 Wheat, grain - babyfood 0.050000 1.000 1.000 1500402000 15 Wheat , flour 0.050000 1.000 1.000 1500402001 15 Wheat, flour - babyfood 0.050000 1.000 1.000 1500403000 15 Wheat, germ 0.050000 1.000 1.000 1500404000 15 Wheat, bran 0.150000 1.000 1.000 1500405000 15 Wild rice 3.500000 1.000 1.000 3100044000 31 Beef, meat 0.100000 1.000 1.000 3100044001 31 Beef, meat - babyfood 0.100000 1.000 1. 000 3100045000 31 Beef, meat, dried 0.100000 1.920 1.000 3100046000 31 Beef, meat byproducts 0.300000 1.000 1.000 3100046001 31 Beef, meat byproducts - babyfood 0.300000 1.000 1.000 3100047000 31 Bee f, fat 0.100000 1.000 1.000 3100047001 31 Beef, fat - babyfood 0.100000 1.000 1.000 3100048000 31 Beef, kidney 0.100000 1.000 1.000 3100049000 31 Beef, liver 0.300000 1.000 1.000 0F6121 3100049001 31 Beef, liver - babyfood 0.300000 1.000 1.000 0F6121 3200169000 32 Goat, meat 0.100000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.3000 00 1.000 1.000 3200171000 32 Goat, fat 0.100000 1.000 1.000 3200172000 32 Goat, kidney 0.100000 1.000 1.000 3200173000 32 Goat, liver 0.300000 1.000 1.000 33001 89000 33 Horse, meat 0.100000 1.000 1.000 3400290000 34 Pork, meat 0.050000 1.000 1.000 3400290001 34 Pork, meat - babyfood 0.050000 1.000 1.000 3400291000 34 Pork, skin 0.050000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.050000 1.000 1.000 3400292001 34 Pork, meat byproducts - babyfood 0.050000 1.000 1.000 3400293000 34 Pork, fat 0.05 0000 1.000 1.000 3400293001 34 Pork, fat - babyfood 0.050000 1.000 1.000 0F6121 3400294000 34 Pork, kidney 0.050000 1.000 1.000 0F6121 3400295000 34 Pork, liver 0.160000 1.000 1.000 0F6121 3500339000 35 Sheep, meat 0.100000 1.000 1.000 3500339001 35 Sheep, meat - babyfood 0.100000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.300000 1.000 1.000 3500341000 35 Sheep, fat 0.100000 1.000 1.000 3500341001 35 Sheep, fat - babyfood 0.100000 1.000 1.000

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 13 of 21 3500342000 35 Sheep, kidney 0.100000 1.000 1.000 3500343000 35 Sheep, liver 0.300000 1.000 1.000 3600222000 36 Milk, fat 0.020000 1.000 1.000 3600222001 36 Milk, fat - baby food/infant formu 0.020000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.020000 1.000 1.000 3600223001 36 Milk, nonfat solids - baby food/in 0.020000 1.000 1.000 3600224000 36 Milk, water 0.020000 1.000 1.000 3600224001 36 Milk, water - babyfood/infant form 0.020000 1.000 1.000 36002250 01 36 Milk, sugar (lactose) - baby food/ 0.020000 1.000 1.000 4000093000 40 Chicken, meat 0.040000 1.000 1.000 0F6121 4000093001 40 Chicken, meat - babyfood 0.040000 1.000 1.000 0F6121 4000094000 40 Chick en, liver 0.040000 1.000 1.000 0F6121 4000095000 40 Chicken, meat byproducts 0.040000 1.000 1.000 0F6121 4000095001 40 Chicken, meat byproducts - babyfoo 0.040000 1.000 1.000 0F6121 4000096000 40 Chicken, fat 0.040000 1.000 1.000 0F6121 4000096001 40 Chicken, fat - babyfood 0.040000 1.000 1.000 0F6121 4000097000 40 Chicken, skin 0.040000 1.000 1.000 0F6121 4000097001 40 Chicken, skin - babyf ood 0.040000 1.000 1.000 0F6121 5000382000 50 Turkey, meat 0.040000 1.000 1.000 0F6121 5000382001 50 Turkey, meat - babyfood 0.040000 1.000 1.000 0F6121 5000383000 50 Turkey, liver 0.040000 1.000 1.000 0F6121 5000383001 50 Turkey, liver - babyfood 0.040000 1.000 1.000 0F6121 5000384000 50 Turkey, meat byproducts 0.040000 1.000 1.000 0F6121 5000384001 50 Turkey, meat byproducts - babyfood 0.040000 1.000 1.000 0F6121 5000385000 50 Turkey, fat 0.040000 1.000 1.000 0F6121 5000385001 50 Turkey, fat - babyfood 0.040000 1.000 1.000 0F6121 5000386000 50 Turkey, skin 0.040 000 1.000 1.000 0F6121 5000386001 50 Turkey, skin - babyfood 0.040000 1.000 1.000 0F6121 6000301000 60 Poultry, other, meat 0.040000 1.000 1.000 0F6121 6000302000 60 Poultry, other, liver 0.040000 1 .000 1.000 0F6121 6000303000 60 Poultry, other, meat byproducts 0.040000 1.000 1.000 0F6121 6000304000 60 Poultry, other, fat 0.040000 1.000 1.000 0F6121 6000305000 60 Poultry, other, skin 0.040000 1.000 1 .000 0F6121 7000145000 70 Egg, whole 0.040000 1.000 1.000 0F6121 7000145001 70 Egg, whole - babyfood 0.040000 1.000 1.000 0F6121 7000146000 70 Egg, white 0.040000 1.000 1.000 0 F6121 7000146001 70 Egg, white (solids) - babyfood 0.040000 1.000 1.000 0F6121 7000147000 70 Egg, yolk 0.040000 1.000 1.000 0F6121 7000147001 70 Egg, yolk - babyfood 0.040000 1.000 1.000 0F6121 8 601000000 86A Water, direct, all sources 0.427000 1.000 1.000 8F7487 8602000000 86B Water, indirect, all sources 0.427000 1.000 1.000 8F7487 9500016000 O Artichoke, globe 1.000000 1.000 1.000 8F7464 95000190 00 O Asparagus 0.070000 1.000 1.000 6E7088 9500023000 O Banana 0.100000 1.000 1.000 9500023001 O Banana - babyfood 0.100000 1.000 1.000 9500024000 O Banana, dri ed 0.100000 3.900 1.000 9500024001 O Banana, dried - babyfood 0.100000 3.900 1.000 9500074000 O Canistel 0.700000 1.000 1.000 9500115000 O Coffee, roasted bean 0 .020000 1.000 1.000 0E7789 9500116000 O Coffee, instant 0.020000 1.000 1.000 0E7789 9500177000 O Grape, leaves 2.000000 1.000 1.000 9500178000 O Grape, raisin 5.000000 1.0 00 1.000 8F7464 9500188000 O Hop 11.000000 1.000 1.000 9500215000 O Mango 0.700000 1.000 1.000 6E7088 9500215001 O Mango - babyfood 0.700000 1.000 1.000 6E 7088 9500216000 O Mango, dried 0.700000 1.000 1.000 6E7088 9500217000 O Mango, juice 0.700000 1.000 1.000 6E7088 9500217001 O Mango, juice - babyfood 0.700000 1.000 1.000 6E7088 95 00245000 O Papaya 0.700000 1.000 1.000 6E7088 9500245001 O Papaya - babyfood 0.700000 1.000 1.000 6E7088 9500246000 O Papaya, dried 0.700000 1.800 1.000 6E7088 950024700 0 O Papaya, juice 0.700000 1.500 1.000 6E7088 9500263000 O Peanut 0.050000 1.000 1.000 9500264000 O Peanut, butter 0.050000 1.890 1.000 9500265000 O Peanut, oil 0.050000 1.000 1.000 9500283000 O Plantain 0.100000 1.000 1.000 9500284000 O Plantain, dried 0.100000 3.900 1.000

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 14 of 21 9500333000 O Sapote, Mamey 0. 700000 1.000 1.000 6E7088 

## Attachment 2: Acute Results File U.S. EPA Ver. 3.16, 03 - 08 - d DEEM - FCID ACUTE Analysis for TRIFLOXYSTROBIN NHANES 2003 - 2008 2 - Day Residue file: ACUTE_FoodWater2 013.R08 Adjustment factor #2 NOT used. Analysis Date: 05 - 21 - 2014/10:39:23 Residue file dated: 05 - 20 - 2014/15:22:05 NOEL (Acute) = 250.000000 mg/kg body - wt/day RAC/FF intake summed over 24 hours Run Comment: "PP#0E7789 (Acute Dietary for Femal es 13 - 49 Only)"

=============================================================================== Summary calculations -- per capita:

--- 95th Percentile ---- --- 99th Percentile ---- --- 99.9th Percentile ---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Female 13 - 49: 0.032259 1.29 7749 0.045068 1.80 5547 0.059044 2.36 4234

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 15 of 21 **Attachment 3**  **: Chronic**  **Food plus Water Residue Input File** Filename: C: \ Users \ mnegussi \ Documents \ DEEM Version 3.16 \ Trifloxystrobin \ CHRONIC_FoodWater2013.R08 Chemical: Trifloxystrobin RfD(Chronic): .038 mg/kg bw/day NOEL(Chronic): 3.8 mg/kg bw/day RfD(Acu te): 2.5 mg/kg bw/day NOEL(Acute): 250 mg/kg bw/day Date created/last modified: 05 - 20 - 2014/15:20:22 Program ver. 3.16, 03 - 08 - d Comment: PP#0F7789 (Acute Dietary Females 13 - 49 Only) water GW 365 ppb

-------------------------------------------------- --------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- -- ---- ------ ------- 0101050000 1AB Beet, garden, roots 0.100000 1.000 1.000 0101050001 1AB Beet, garden, roots - babyfood 0.100000 1.000 1.000 0101052000 1A Beet, sugar 0.100000 1.000 1.000 0101 052001 1A Beet, sugar - babyfood 0.100000 1.000 1.000 0101053000 1A Beet, sugar, molasses 0.200000 1.000 1.000 0101053001 1A Beet, sugar, molasses - babyfood 0.200000 1.000 1.000 0101067000 1AB Burdock 0.100000 1.000 1.000 0101078000 1AB Carrot 0.100000 1.000 1.000 0101078001 1AB Carrot - babyfood 0.100000 1.000 1.000 0101079000 1AB Carrot, juice 0.1 00000 1.000 1.000 0101084000 1AB Celeriac 0.100000 1.000 1.000 0101100000 1AB Chicory, roots 0.100000 1.000 1.000 0101168000 1AB Ginseng, dried 0.100000 1.000 1.000 01 01190000 1AB Horseradish 0.100000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.100000 1.000 1.000 0101251000 1AB Parsnip 0.100000 1.000 1.000 0101251001 1AB Parsnip - bab yfood 0.100000 1.000 1.000 0101314000 1AB Radish, roots 0.100000 1.000 1.000 6E7088 0101316000 1AB Radish, Oriental, roots 0.100000 1.000 1.000 6E7088 0101327000 1AB Rutabaga 0.100000 1.000 1.000 0101331000 1AB Salsify, roots 0.100000 1.000 1.000 0101388000 1AB Turnip, roots 0.100000 1.000 1.000 0103296000 1C Potato, chips 0.040000 1.0 00 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.040000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes) - b 0.040000 6.500 1.000 0103298000 1C Potato, flour 0.040000 6.500 1.000 0103298001 1C Potato, flour - babyfood 0.040000 6.500 1.000 0103299000 1C Potato, tuber, w/peel 0.040000 1.000 1.000 0103299001 1C Potato, tuber, w/peel - babyfood 0.040000 1.000 1.000 0103300000 1C Potato, tuber, w/o pee l 0.040000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel - babyfood 0.040000 1.000 1.000 0200051000 2 Beet, garden, tops 4.000000 1.000 1.000 0200315000 2 Radish, tops 10.000000 1 .000 1.000 6E7088 0200317000 2 Radish, Oriental, tops 10.000000 1.000 1.000 6E7088 0402076000 4B Cardoon 3.500000 1.000 1.000 8F7464 0402085000 4B Celery 3.500000 1.000 1 .000 8F7464 0402085001 4B Celery - babyfood 3.500000 1.000 1.000 8F7464 0402086000 4B Celery, juice 3.500000 1.000 1.000 8F7464 0402087000 4B Celtuce 3.500000 1.000 1.000 8 F7464 0402152000 4B Fennel, Florence 3.500000 1.000 1.000 8F7464 0402322000 4B Rhubarb 3.500000 1.000 1.000 8F7464 0402367000 4B Swiss chard 3.500000 1.000 1.000 8F7464 0 600347000 6 Soybean, seed 0.080000 1.000 1.000 5F6956 0600349000 6 Soybean, soy milk 0.080000 1.000 1.000 5F6956 0600349001 6 Soybean, soy milk - babyfood or in 0.080000 1.000 1.000 5F6956 06003500 00 6 Soybean, oil 0.080000 1.000 1.000 5F6956 0600350001 6 Soybean, oil - babyfood 0.080000 1.000 1.000 5F6956 0601349500 6AB Soybean, vegetable 0.080000 1.000 1.000 0603098000 6C Chick pea, seed 0.060000 1.000 1.000 0603098001 6C Chickpea, seed - babyfood 0.060000 1.000 1.000 0603099000 6C Chickpea, flour 0.060000 1.000 1.000 3F8180

Full comment: 3F8180 DP# 413 711 0603203000 6C Lentil, seed 0.060000 1.000 1.000 3F8180

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 16 of 21

Full comment: 3F8180 DP# 413711 0603256000 6C Pea, dry 0.060000 1.000 1.000 0603256001 6C Pea, dry - babyfood 0.060000 1.000 1.000 0603258000 6C Pea, pigeon, seed 0.060000 1.000 1.000 3F8180

Full comment: 3F8180 DP# 413711 0603348000 6C Soybean, flour 0.080000 1.000 1.000 5F6956 0603348001 6C S oybean, flour - babyfood 0.080000 1.000 1.000 5F6956 0801374000 8A Tomatillo 0.500000 1.000 1.000 0801375000 8A Tomato 0.500000 1.000 1.000 0801375001 8A Tomato - babyfood 0.500000 1.000 1.000 0801376000 8A Tomato, paste 0.500000 5.400 1.000 0801376001 8A Tomato, paste - babyfood 0.500000 5.400 1.000 0801377000 8A Tomato, puree 0.500000 3.300 1.000 0801377001 8A Tomato, puree - babyfood 0.500000 3.300 1.000 0801378000 8A Tomato, dried 0.500000 14.300 1.000 0801378001 8A Tomato, dried - babyfood 0.500000 14.300 1.000 080137900 0 8A Tomato, juice 0.500000 1.500 1.000 0801380000 8A Tomato, Tree 0.500000 1.000 1.000 0802148000 8BC Eggplant 0.500000 1.000 1.000 0802234000 8BC Okra 0.500000 1.000 1.000 8F7464 0802270000 8B Pepper, bell 0.500000 1.000 1.000 0802270001 8B Pepper, bell - babyfood 0.500000 1.000 1.000 0802271000 8B Pepper, bell, dried 0. 500000 1.000 1.000 0802271001 8B Pepper, bell, dried - babyfood 0.500000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.500000 1.000 1.000 0802272001 8BC Pepper, nonbell - babyfood 0.500000 1.000 1.000 0 802273000 8BC Pepper, nonbell, dried 0.500000 1.000 1.000 0901075000 9A Cantaloupe 0.500000 1.000 1.000 0901187000 9A Honeydew melon 0.500000 1.000 1.000 0901399000 9A Watermelon 0.500000 1.000 1.000 0901400000 9A Watermelon, juice 0.500000 1.000 1.000 0902021000 9B Balsam pear 0.500000 1.000 1.000 0902088000 9B Chayote, fruit 0.500000 1.000 1.000 0902102000 9B Chinese waxgourd 0.500000 1.000 1.000 0902135000 9B Cucumber 0.500000 1.000 1.000 0902308000 9B Pumpkin 0.500000 1.000 1.000 0902309000 9B Pumpkin, seed 0.500000 1.000 1.000 0902356000 9B Squash, summer 0.500000 1.000 1.000 0902356001 9B Squash, summer - babyfood 0.500000 1.000 1.000 0902357000 9B Squash, winter 0.500000 1.000 1.000 0902357001 9B Squash, winter - babyfood 0.500000 1.000 1.000 1001106000 10A Citron 0.600000 1.000 1.000 0F6121 1001107000 10A Citrus hybrids 0.600000 1.000 1.000 0F6121 1001108000 10A Citrus, oil 38.000000 1.000 1.000 0F6121 1001240000 10A Orange 0.150000 1.000 1.000 0F6121 1001241000 10A Orange, juice 0.150000 1.800 1.000 0F6121 1001241001 10A Orange, juice - babyfood 0.150000 1.800 1.000 0F6121 1001242000 10A Orange, peel 0.150000 1.000 1.000 0F6121 1001369000 10A Tangerine 0.6000 00 1.000 1.000 0F6121 1001370000 10A Tangerine, juice 0.600000 2.300 1.000 0F6121 1002197000 10B Kumquat 0.600000 1.000 1.000 1002199000 10B Lemon 0.600000 1.000 1 .000 0F6121 1002200000 10B Lemon, juice 0.600000 2.000 1.000 0F6121 1002200001 10B Lemon, juice - babyfood 0.600000 2.000 1.000 0F6121 1002201000 10B Lemon, peel 0.600000 1.000 1.000 0 F6121 1002206000 10B Lime 0.600000 1.000 1.000 0F6121 1002207000 10B Lime, juice 0.600000 2.000 1.000 0F6121 1002207001 10B Lime, juice - babyfood 0.600000 2.000 1.000 0F6121 1 003180000 10C Grapefruit 0.600000 1.000 1.000 0F6121 1003181000 10C Grapefruit, juice 0.600000 2.100 1.000 0F6121 1003307000 10C Pummelo 0.600000 1.000 1.000 1100007000 11 Apple, fruit with peel 0.200000 1.000 1.000 1100008000 11 Apple, peeled fruit 0.200000 1.000 1.000 1100008001 11 Apple, peeled fruit - babyfood 0.200000 1.000 1.000 1100009000 11 Apple, dried 0.200000 8.000 1.000 1100009001 11 Apple, dried - babyfood 0.200000 8.000 1.000 1100010000 11 Apple, juice 0.200000 1.300 1.000

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 17 of 21 1100010001 11 Apple, juice - babyfood 0.200000 1. 300 1.000 1100011000 11 Apple, sauce 0.200000 1.000 1.000 1100011001 11 Apple, sauce - babyfood 0.200000 1.000 1.000 1100129000 11 Crabapple 0.200000 1.000 1.000 1100173500 1 1 Goji berry 0.500000 1.000 1.000 1100210000 11 Loquat 0.200000 1.000 1.000 1100266000 11 Pear 0.200000 1.000 1.000 1100266001 11 Pear - babyfood 0.200000 1.000 1.000 1100267000 11 Pear, dried 0.200000 6.250 1.000 1100268000 11 Pear, juice 0.200000 1.000 1.000 1100268001 11 Pear, juice - babyfood 0.200000 1.000 1.000 1100310000 11 Quince 0.200000 1.000 1.000 1201090000 12A Cherry 2.000000 1.000 1.000 0F6121 1201090001 12A Cherry - babyfood 2.000000 1.000 1.000 0F612 1 1201091000 12A Cherry, juice 2.000000 1.500 1.000 0F6121 1201091001 12A Cherry, juice - babyfood 2.000000 1.500 1.000 0F6121 1202012000 12B Apricot 2.000000 1.000 1.000 0F6121 12020 12001 12B Apricot - babyfood 2.000000 1.000 1.000 0F6121 1202013000 12B Apricot, dried 2.000000 6.000 1.000 0F6121 1202014000 12B Apricot, juice 2.000000 1.000 1.000 0F6121 1202014001 1 2B Apricot, juice - babyfood 2.000000 1.000 1.000 0F6121 1202230000 12B Nectarine 2.000000 1.000 1.000 0F6121 1202260000 12B Peach 2.000000 1.000 1.000 0F6121 1202260001 12B Pea ch - babyfood 2.000000 1.000 1.000 0F6121 1202261000 12B Peach, dried 2.000000 7.000 1.000 0F6121 1202261001 12B Peach, dried - babyfood 2.000000 7.000 1.000 0F6121 1202262000 12B Peach, jui ce 2.000000 1.000 1.000 1202262001 12B Peach, juice - babyfood 2.000000 1.000 1.000 1203285000 12C Plum 2.000000 1.000 1.000 0F6121 1203285001 12C Plum - babyfood 2.000000 1.000 1.000 0F6121 1203286000 12C Plum, prune, fresh 2.000000 1.000 1.000 0F6121 1203286001 12C Plum, prune, fresh - babyfood 2.000000 1.000 1.000 0F6121 1203287000 12C Plum, prune, dried 2 .000000 5.000 1.000 0F6121 1203287001 12C Plum, prune, dried - babyfood 2.000000 5.000 1.000 0F6121 1203288000 12C Plum, prune, juice 2.000000 1.400 1.000 0F6121 1203288001 12C Plum, prune, juice - babyfood 2.000000 1.400 1.000 0F6121 1304175000 13D Grape 0.400000 1.000 1.000 1304176000 13D Grape, juice 0.400000 1.200 1.000 1304176001 13D Grape, juice - babyfood 0.400000 1.200 1.000 1 304179000 13D Grape, wine and sherry 0.400000 1.000 1.000 1307359000 13G Strawberry 1.100000 1.000 1.000 8F7464 1307359001 13G Strawberry - babyfood 1.100000 1.000 1.000 8F7464 1307360000 13G Strawberry, juice 1.100000 1.000 1.000 8F7464 1307360001 13G Strawberry, juice - babyfood 1.100000 1.000 1.000 8F7464 1400003000 14 Almond 0.040000 1.000 1.000 1400003001 14 Almond - baby food 0.040000 1.000 1.000 1400004000 14 Almond, oil 0.040000 1.000 1.000 1400004001 14 Almond, oil - babyfood 0.040000 1.000 1.000 1400059000 14 Brazil nut 0 .040000 1.000 1.000 0F6121 1400068000 14 Butternut 0.040000 1.000 1.000 1400081000 14 Cashew 0.040000 1.000 1.000 0F6121 1400092000 14 Chestnut 0.040000 1.0 00 1.000 0F6121 1400155000 14 Hazelnut 0.040000 1.000 1.000 0F6121 1400156000 14 Hazelnut, oil 0.040000 1.000 1.000 0F6121 1400185000 14 Hickory nut 0.040000 1.000 1.0 00 1400213000 14 Macadamia nut 0.040000 1.000 1.000 0F6121 1400269000 14 Pecan 0.040000 1.000 1.000 0F6121 1400278000 14 Pine nut 0.040000 1.000 1.000 14002820 00 14 Pistachio 0.040000 1.000 1.000 0F6121 1400391000 14 Walnut 0.040000 1.000 1.000 0F6121 1500025000 15 Barley, pearled barley 0.050000 1.000 1.000 1500025001 15 Barle y, pearled barley - babyfood 0.050000 1.000 1.000 1500026000 15 Barley, flour 0.050000 1.000 1.000 1500026001 15 Barley, flour - babyfood 0.050000 1.000 1.000 1500027000 15 Barley, bran 0.050000 1.000 1.000 1500065000 15 Buckwheat 0.050000 1.000 1.000 1500066000 15 Buckwheat, flour 0.050000 1.000 1.000

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 18 of 21 1500120000 15 Corn, field, flour 0.050000 1.000 1. 000 0F6121 1500120001 15 Corn, field, flour - babyfood 0.050000 1.000 1.000 0F6121 1500121000 15 Corn, field, meal 0.050000 1.000 1.000 0F6121 1500121001 15 Corn, field, meal - babyfood 0.050000 1.000 1.000 0F 6121 1500122000 15 Corn, field, bran 0.050000 1.000 1.000 0F6121 1500123000 15 Corn, field, starch 0.050000 1.000 1.000 0F6121 1500123001 15 Corn, field, starch - babyfood 0.050000 1.000 1.000 0F6121 15 00124000 15 Corn, field, syrup 0.050000 1.500 1.000 0F6121 1500124001 15 Corn, field, syrup - babyfood 0.050000 1.500 1.000 0F6121 1500125000 15 Corn, field, oil 0.100000 1.000 1.000 0F6121 150012500 1 15 Corn, field, oil - babyfood 0.100000 1.000 1.000 0F6121 1500126000 15 Corn, pop 0.050000 1.000 1.000 0F6121 1500127000 15 Corn, sweet 0.040000 1.000 1.000 1500127001 15 Corn, sweet - babyfood 0.040000 1.000 1.000 1500231000 15 Oat, bran 0.050000 1.000 1.000 1500232000 15 Oat, flour 0.050000 1.000 1.000 1500232001 15 Oat, flour - babyfood 0.050000 1.000 1.000 1500233000 15 Oat, groats/rolled oats 0.050000 1.000 1.000 1500233001 15 Oat, groats/rolled oats - babyfood 0.050000 1.000 1.000 1500323000 15 Rice, white 3.500000 1.000 1.0 00 0F6121 1500323001 15 Rice, white - babyfood 3.500000 1.000 1.000 0F6121 1500324000 15 Rice, brown 3.500000 1.000 1.000 0F6121 1500324001 15 Rice, brown - babyfood 3.500000 1.000 1.000 0F6 121 1500325000 15 Rice, flour 3.500000 1.000 1.000 0F6121 1500325001 15 Rice, flour - babyfood 3.500000 1.000 1.000 0F6121 1500326000 15 Rice, bran 3.500000 1.000 1.000 0F6121 150 0326001 15 Rice, bran - babyfood 3.500000 1.000 1.000 0F6121 1500381000 15 Triticale, flour 0.050000 1.000 1.000 1500381001 15 Triticale, flour - babyfood 0.050000 1.000 1.000 1500401000 15 Wheat, grain 0.050000 1.000 1.000 1500401001 15 Wheat, grain - babyfood 0.050000 1.000 1.000 1500402000 15 Wheat, flour 0.050000 1.000 1.000 1500402001 15 Wheat, flour - babyfood 0.050000 1.000 1.000 1500403000 15 Wheat, germ 0.050000 1.000 1.000 1500404000 15 Wheat, bran 0.150000 1.000 1.000 1500405000 15 Wild rice 3.500000 1.000 1.0 00 3100044000 31 Beef, meat 0.100000 1.000 1.000 3100044001 31 Beef, meat - babyfood 0.100000 1.000 1.000 3100045000 31 Beef, meat, dried 0.100000 1.920 1.000 3100046000 31 Beef , meat byproducts 0.300000 1.000 1.000 3100046001 31 Beef, meat byproducts - babyfood 0.300000 1.000 1.000 3100047000 31 Beef, fat 0.100000 1.000 1.000 3100047001 31 Beef, fat - babyfood 0.100000 1.000 1.000 3100048000 31 Beef, kidney 0.100000 1.000 1.000 3100049000 31 Beef, liver 0.300000 1.000 1.000 0F6121 3100049001 31 Beef, liver - babyfood 0.300000 1. 000 1.000 0F6121 3200169000 32 Goat, meat 0.100000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.300000 1.000 1.000 3200171000 32 Goat, fat 0.100000 1.000 1.000 320017 2000 32 Goat, kidney 0.100000 1.000 1.000 3200173000 32 Goat, liver 0.300000 1.000 1.000 3300189000 33 Horse, meat 0.100000 1.000 1.000 3400290000 34 Pork, meat 0.050000 1.000 1.000 3400290001 34 Pork, meat - babyfood 0.050000 1.000 1.000 3400291000 34 Pork, skin 0.050000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.050 000 1.000 1.000 3400292001 34 Pork, meat byproducts - babyfood 0.050000 1.000 1.000 3400293000 34 Pork, fat 0.050000 1.000 1.000 3400293001 34 Pork, fat - babyfood 0.050000 1.000 1.000 0F612 1 3400294000 34 Pork, kidney 0.050000 1.000 1.000 0F6121 3400295000 34 Pork, liver 0.160000 1.000 1.000 0F6121 3500339000 35 Sheep, meat 0.100000 1.000 1.000 3500339001 35 Sheep, meat - babyfood 0.100000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.300000 1.000 1.000 3500341000 35 Sheep, fat 0.100000 1.000 1.000 3500341001 35 Sheep, fat - babyfood 0.100000 1.000 1.000 3500342000 35 Sheep, kidney 0.100000 1.000 1.000

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 19 of 21 3500343000 35 Sheep, liver 0.300000 1.000 1.000 3600222000 36 Milk, fat 0.020000 1.000 1.000 3600222001 36 Milk, fat - baby food/infant formu 0.020000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.020000 1.000 1.000 3600223001 36 Milk, nonfat solids - baby food/in 0.020000 1.000 1.000 360022400 0 36 Milk, water 0.020000 1.000 1.000 3600224001 36 Milk, water - babyfood/infant form 0.020000 1.000 1.000 3600225001 36 Milk, sugar (lactose) - baby food/ 0.020000 1.000 1.000 4000093000 40 Chicken, meat 0.040000 1.000 1.000 0F6121 4000093001 40 Chicken, meat - babyfood 0.040000 1.000 1.000 0F6121 4000094000 40 Chicken, liver 0.040000 1.000 1.000 0F6121 4000095000 40 Chicken, meat byproducts 0.040000 1.000 1.000 0F6121 4000095001 40 Chicken, meat byproducts - babyfoo 0.040000 1.000 1.000 0F6121 4000096000 40 Chicken, fat 0.040000 1.000 1.000 0F6121 4000096001 40 Chicken, fat - babyfood 0.040000 1.000 1.000 0F6121 4000097000 40 Chicken, skin 0.040000 1.000 1.000 0F6121 4000097001 40 Chicken, skin - babyfood 0.040000 1.000 1.000 0F6121 5000382000 50 Turkey, meat 0.04 0000 1.000 1.000 0F6121 5000382001 50 Turkey, meat - babyfood 0.040000 1.000 1.000 0F6121 5000383000 50 Turkey, liver 0.040000 1.000 1.000 0F6121 5000383001 50 Turkey, liver - babyfood 0.040000 1.000 1.000 0F6121 5000384000 50 Turkey, meat byproducts 0.040000 1.000 1.000 0F6121 5000384001 50 Turkey, meat byproducts - babyfood 0.040000 1.000 1.000 0F6121 5000385000 50 Turkey, fat 0.040000 1.000 1.000 0F6121 5000385001 50 Turkey, fat - babyfood 0.040000 1.000 1.000 0F6121 5000386000 50 Turkey, skin 0.040000 1.000 1.000 0F6121 5000386001 50 Turkey, skin - babyfood 0.040000 1.000 1.000 0F6121 6000301000 60 Poultry, other, meat 0.040000 1.000 1.000 0F6121 6000302000 60 Poultry, other, liver 0.040000 1.000 1.000 0F6121 6000303000 60 Poultry, other, meat byproducts 0.040000 1.000 1.000 0F6121 6000304000 60 Poultry, other, fat 0.040000 1.000 1.000 0F6121 6000305000 60 Poultry, other, skin 0.040000 1.000 1.000 0F6121 7000145000 70 Egg, whole 0.040000 1.000 1.000 0F6121 7000145 001 70 Egg, whole - babyfood 0.040000 1.000 1.000 0F6121 7000146000 70 Egg, white 0.040000 1.000 1.000 0F6121 7000146001 70 Egg, white (solids) - babyfood 0.040000 1.000 1.000 0F6121 7000147000 70 Egg, yolk 0.040000 1.000 1.000 0F6121 7000147001 70 Egg, yolk - babyfood 0.040000 1.000 1.000 0F6121 8601000000 86A Water, direct, all sources 0.365000 1.000 1.000 8F7487 8602000000 86B Water , indirect, all sources 0.365000 1.000 1.000 8F7487 9500016000 O Artichoke, globe 1.000000 1.000 1.000 8F7464 9500019000 O Asparagus 0.070000 1.000 1.000 6E7088 9500023000 O Banana 0.100000 1.000 1.000 9500023001 O Banana - babyfood 0.100000 1.000 1.000 9500024000 O Banana, dried 0.100000 3.900 1.000 9500024001 O Banana, dried - babyfood 0. 100000 3.900 1.000 9500074000 O Canistel 0.700000 1.000 1.000 9500115000 O Coffee, roasted bean 0.020000 1.000 1.000 0E7789 9500116000 O Coffee, instant 0.020000 1.000 1.0 00 0E7789 9500177000 O Grape, leaves 0.400000 1.000 1.000 9500178000 O Grape, raisin 5.000000 1.000 1.000 8F7464 9500188000 O Hop 11.000000 1.000 1.000 95002150 00 O Mango 0.700000 1.000 1.000 6E7088 9500215001 O Mango - babyfood 0.700000 1.000 1.000 6E7088 9500216000 O Mango, dried 0.700000 1.000 1.000 6E7088 9500217000 O Mango, juice 0.700000 1.000 1.000 6E7088 9500217001 O Mango, juice - babyfood 0.700000 1.000 1.000 6E7088 9500245000 O Papaya 0.700000 1.000 1.000 6E7088 9500245001 O Papaya - babyfood 0.700000 1.000 1.000 6E7088 9500246000 O Papaya, dried 0.700000 1.800 1.000 6E7088 9500247000 O Papaya, juice 0.700000 1.500 1.000 6E7088 9500263000 O Peanut 0.050000 1.000 1.000 9500264000 O Peanut, butter 0.050000 1.890 1.000 9500265000 O Peanut, oil 0.050000 1.000 1.000 9500283000 O Plantain 0.1 00000 1.000 1.000 9500284000 O Plantain, dried 0.100000 3.900 1.000 9500333000 O Sapote, Mamey 0.700000 1.000 1.000 6E7088

### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 20 of 21 **Attachment 4: Chronic Food and Water**  **Results File**

U.S. EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Chronic analysis for TRIFLOXYSTROBIN NHANES 2003 - 2008 2 - day Residue file name: C: \ Documents and Settings \ MNEGUSSI \ My Documents \ DEEM Version 3.16 \ Trifloxystrobin \ CHRONIC_Fo odWater2013.R08 Adjustment factor #2 NOT used. Analysis Date 05 - 21 - 2014/10:36:43 Residue file dated: 05 - 20 - 2014/15:20:22 Reference dose (RfD, Chronic) = .038 mg/kg bw/day

================================ =============================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

--------------------------- ----------- ------------- ---------------- Total US Population 0.012139 31.9% Hispanic 0.012815 33.7% Non - Hisp - White 0.012049 31.7% Non - Hisp - Black 0.010498 27.6% Non - Hisp - Other 0.015487 40.8% Nursing Infants 0.013417 35.3% Non - Nursing Infan ts 0.037045 97.5% Female 13+ PREG 0.011279 29.7% Children 1 - 6 0.022181 58.4% Children 7 - 12 0.01199 8 31.6% Male 13 - 19 0.008623 22.7% Female 13 - 19/NP 0.009141 24.1% Male 20+ 0.010888 28.7% Female 20+/ NP 0.011299 29.7% Seniors 55+ 0.010686 28.1% All Infants 0.029751 78.3% Female 13 - 50 0 .010893 28.7% Children 1 - 2 0.026545 69.9% Children 3 - 5 0.020721 54.5% Children 6 - 12 0.012755 33.6% Youth 13 - 19 0.008879 23.4% Adults 20 - 49 0.011282 29.7% Adults 50 - 99 0.010870 28.6% Female 13 - 49 0.010893 28.7%

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### Trifloxystrobin Dietary Exposure and Risk Assessment DP Number: 413712

PC Code: 129112



## Page 21 of 21 **Attachment 5**  **: Chronic Food only**  **Results File** U.S. EPA Ver. 3. 16, 03 - 08 - d DEEM - FCID Chronic analysis for TRIFLOXYSTROBIN NHANES 2003 - 2008 2 - day Residue file name: C: \ Documents and Settings \ MNEGUSSI \ My Documents \ DEEM Version 3.16 \ Trifloxystrobin \ CHRONIC_Food2013.R08 Adjustment factor #2 NOT used. Analysis Date 05 - 21 - 2014/10:44:04 Residue file dated: 05 - 21 - 2014/10:43:16 Reference dose (RfD, Chronic) = .038 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------- ------------------ Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.004496 11.8% Hispanic 0.005518 14.5% Non - Hisp - White 0.004189 11.0% Non - Hisp - Black 0.004191 11.0% Non - Hisp - Other 0.006678 17.6% Nursing Infants 0.006503 17.1% Non - Nursing Infants 0.011625 30.6% Female 13+ PREG 0.004082 10.7% Children 1 - 6 0.012392 32.6% Children 7 - 12 0.005626 14.8% Male 13 - 19 0.003369 8.9% Female 13 - 19/NP 0.003254 8.6% Male 20+ 0.003767 9.9% Female 20+/NP 0.003272 8.6% Seniors 55+ 0.003296 8.7% All Infants 0.010044 26.4% Female 13 - 50 0.003287 8.6% Children 1 - 2 0.015520 40.8% Children 3 - 5 0.011432 30.1% Children 6 - 12 0.006056 15.9% Youth 13 - 19 0.003306 8.7% Adults 20 - 49 0.003657 9.6% Adults 50 - 99 0.003331 8.8% Female 13 - 49 0.003295 8.7%

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