Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

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 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

Office of Chemical Safety 

 and Pollution Prevention

MEMORANDUM

DATE: Nov 23, 2010 

SUBJECT: Thiamethoxam. Acute and Chronic Aggregate Dietary (Food and Drinking 

Water) Exposure and Risk Assessments for the Section 3 Registration as a Seed 

Treatment for Alfalfa and Peanuts, and for Use in Food Handling Establishments. 

PC Code: 060109 DP Barcode: D376368 

Decision Number: D424517 Registration Numbers: 100-

RGAL, 100-941, 1001306 

Petition Numbers: 9F7657, 9F7707, 0F7734 Regulatory Action: Section 3 

 Registration 

Assessment Type: Dietary Case Number: 7614 

TXR Number: NA CAS Number: 153719-23-4 

MRID Number: NA 40CFR §180.565 

REVIEWER: Dennis McNeilly, Chemist 

 Risk Assessment Branch II (RAB2) 

Health Effects Division (HED), 7509P 

THROUGH: Donna Davis, Chemist 

 David Hrdy, Biologist 

Dietary Exposure Science Advisory Council (DESAC) 

Health Effects Division (HED), 7509P 

TO: Kable Davis/Venus Eagle, Team 01 

 Insecticide/Rodenticide Branch 

 Registration Division (RD), 7505P 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

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Executive Summary 

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments 

were conducted using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database (DEEM-FCIDTM), Version 2.03, which uses food consumption data 

from the US Department of Agriculture’s Continuing Surveys of Food Intakes by Individuals 

(CSFII), collected from 1994 to 1996, and 1998. These analyses were performed to support the 

Section 3 request for thiamethoxam use as a seed treatment for alfalfa and peanuts, and for the 

treatment of food handling establishments. 

Tolerances for residues of thiamethoxam are listed in 40 CFR §180.565 and are expressed in 

terms of the combined residues of the insecticide thiamethoxam and its metabolite CGA-322704. 

Thiamethoxam’s major metabolite is CGA-322704, which is also the registered active ingredient 

clothianidin. Clothianidin has a complete toxicological database and appears to have effects in 

mammals that are different from those of thiamethoxam. Prior to receipt of the complete toxicity 

database for clothianidin, the Agency assumed, based on structural similarity, that the toxicity 

profile for clothianidin was equivalent to thiamethoxam, and conducted risk assessments on the 

combined thiamethoxam and clothianidin residues. The Agency notes that the complete 

database has demonstrated that clothianidin does not have the same toxicity profile and residues 

of clothianidin need not be added to residues of thiamethoxam and compared to the 

thiamethoxam endpoints for risk assessment, instead separate dietary exposure and risk 

assessments should be conducted for thiamethoxam and clothianidin. However, given the 

complexity of previous combined assessments, the Agency is continuing to include residues of 

clothianidin from thiamethoxam uses in the thiamethoxam risk assessment recognizing that this 

is an overestimate of risk. Since risks for thiamethoxam using combined residue values are not 

of concern, it is not necessary at this time to revisit previous dietary inputs and separate out 

residues of the parent compound only. A separate risk assessment which addresses risks from 

clothianidin residues resulting from the direct application of clothianidin as well as risks from 

residues of clothianidin coming from thiamethoxam uses is being conducted (Michael Doherty, 

D384145) concurrently to support the new uses that are the subject of this action. 

The acute assessment is based on tolerance level residues of thiamethoxam/clothianidin (the 

tolerance is for combined residues). The chronic analysis is based on tolerance level/proposed 

tolerance levels and/or average field trial (D376367, W. Drew, 2 Nov 2010) residues and 

assumes 100% crop treated for all commodities. For the chronic analysis, an anticipated residue 

of 0.01 ppm was used for residues in or on all commodities for which there are no existing or 

proposed thiamethoxam tolerances since the proposed new uses include food handling 

establishment use. The assumption of 100% CT in these analyses (acute and chronic) results in a 

conservative assessment for thiamethoxam. The analyses included direct incorporation of 

estimated thiamethoxam/clothianidin residues in drinking water. Clothianidin is not a major 

degradate of thiamethoxam in water; therefore the water numbers reflect residues of the parent 

compound only. For water, the highest estimate from conservative models was used for both the 

acute and the chronic dietary exposure analyses. 
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Based on these highly conservative assumptions, acute dietary (food and water) risk estimates at 

the 95th percentile of exposure are less than or equal to 9.5% of the acute population-adjusted 

dose (aPAD) for all population subgroups. Chronic dietary (food and water) risk estimates are 

less than or equal to 43% of the chronic population-adjusted dose (cPAD) for all population 

subgroups. Generally, HED is concerned when risk estimates exceed 100% of the PAD; 

therefore, all acute and chronic dietary risk estimates are below HED’s level of concern (LOC). 

These analyses indicate that there are no dietary exposure considerations that would preclude 

registration of thiamethoxam for the requested seed treatment uses on alfalfa and peanuts, and 

the treatment of food handling establishments. 

1. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(the dose which HED has concluded will result in no unreasonable adverse health effects). This 

dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the point of 

departure (POD), such as the NOAEL or LOAEL, divided by the requisite uncertainty and/or 

safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in 

more detail are available on the EPA pesticides web site, Available Information on Assessing 

Exposure from Pesticides, A User’s Guide (21 June 2000), which can be accessed via the web 

link http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf (or see SOP 99.6, 

dated 8/20/1999). 

The most recent dietary risk assessment for thiamethoxam was conducted by D. McNeilly 

(D373595, 3 May 2010). 

2. Residue Information

Tolerances have been established for both thiamethoxam (40CFR §180.565) and clothianidin 

(40CFR §180.586) on a variety of commodities. This assessment includes residue estimates 

associated with the requested Section 3 registration of thiamethoxam use as a seed treatment for 

alfalfa and peanuts, and for the thiamethoxam treatment of food handling establishments (see 

Table 2). The residue of concern for this dietary risk assessment is thiamethoxan and its 

metabolite, clothianidin. 

As discussed above, thiamethoxam’s major metabolite is CGA-322704, which is also the 

registered active ingredient clothianidin. Clothianidin has a complete toxicological database and 

appears to have effects in mammals that are different from those of thiamethoxam. Prior to 

receipt of the complete toxicity database for clothianidin, the Agency assumed, based on 

structural similarity, that the toxicity profile for clothianidin was equivalent to thiamethoxam, 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

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and conducted risk assessments on the combined thiamethoxam and clothianidin residues. The 

Agency notes that the complete database has demonstrated that clothianidin does not have the 

same toxicity profile and residues of clothianidin need not be added to residues of thiamethoxam 

and compared to the thiamethoxam endpoints for risk assessment, instead separate dietary 

exposure and risk assessments should be conducted for thiamethoxam and clothianidin. 

However, given the complexity of previous combined assessments, the Agency is continuing to 

include residues of clothianidin from thiamethoxam uses in the thiamethoxam risk assessment 

recognizing that this is an overestimate of risk. 

Table 1. HED-Recommended Tolerances for Thiamethoxam’s Proposed Uses in/on Alfalfa, Peanuts and 

Food Handling Establishment Use. 

Commodity Proposed Tolerance 

(ppm) 

Recommended 

Tolerance (ppm) 

Comments; Correct Commodity 

Definition

Tolerances Proposed under 180.565(a) 

Alfalfa, forage 0.05 0.05 Seed treatment 

Alfalfa, hay 0.12 0.12 Seed treatment 

Food Handling Est. 0.01 0.02 

Peanut 0.05 0.05 Seed treatment 

Peanut, hay 0.25 0.25 Seed treatment 

Peanut, meal None 0.15 Seed treatment 

Acute Assessment 

The acute assessment is based on tolerance level residues of thiamethoxam/clothianidin (the 

tolerance is for combined residues). The drinking water estimate for the acute analysis provided 

in Table 2 includes residues of thiamethoxam from thiamethoxam uses, and is discussed in 

Section 3 below. A complete listing of the residues and processing factors used in the acute 

analysis are included in Attachment 1. 

Chronic Assessment 

Most of the inputs are derived from HED’s June 30, 2009 review for thiamethoxam (D364256, 

Dennis McNeilly) and updated with anticipated residues for the proposed peanut and food 

handling establishment uses. A complete listing of the residues and processing factors used in 

the chronic analysis are in Attachment 2. 

 

The chronic assessment makes use of tolerance level residues (peanuts only), average residue 

values or the highest observed residue value from the thiamethoxam field trials. Anticipated 

residues were evaluated for selected commodities only, which were listed in HED’s dietary 

analyses for thiamethoxam (D364256, D. McNeilly, 30 June 2009) and to which are added the 
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residue estimates for proposed uses on alfalfa, peanuts, and the food handling establishment 

treatment. Although monitoring data are available for some commodities, field trial residues 

were used for all the uses, along with a high end estimate of drinking water residues. Therefore 

this assessment is considered highly conservative. 

Food Handling Establishments 

The data supporting thiamethoxam use in food handling areas included a variety of food 

commodities exposed to thiamethoxam, in two different types of food handling establishments, 

at 1X the maximum proposed rate. Based on maximum thiamethoxam and CGA-322704 

residues of <0.01 ppm in food commodities exposed to 1X treatment in food handling areas (the 

majority of samples had non-detectable residues), HED recommends a tolerance of 0.02 ppm in 

food/feed commodities (other than those covered by a higher tolerance as a result of use on 

growing crops) and will use an anticipated residue of 0.01 ppm in DEEM. All samples had 

residues values below the LOQ of <0.01, for both thiamethoxam and the metabolite CGA322704 (combined LOQ = 0.02 ppm). 

Processing factors 

There are no processed commodities associated with the proposed use on alfalfa or the use in 

food handling establishments. The processed commodities associated with the proposed use on 

peanuts are peanut meal (an animal feed item) and refined oil. Reduction of thiamethoxam 

residues in peanut oil after processing ranged from 0.22x -0.40x; an average processing factor of 

0.31x will be used in DEEM. 

Empirical processing factors were used when available. For food forms without empirical 

processing factors, DEEM 7.81 default values were used. A complete listing of the empirical 

processing factors used can be found in Table 2 below. Note: Processing factors are not used 

and use of them would not be appropriate for residue estimates resulting from food handling 

establishment use. 

Livestock 

HED has reevaluated the poultry dietary burden and determined that at the 1X feeding level, 

residues in poultry commodities would still be <LOQ. HED concludes that residues in eggs and 

poultry meat, fat, and meat byproducts remain a 40CFR §180.6[a][3] situation (there is no 

expectation of finite residues in these commodities). As a result, tolerances are still not required 

in any poultry commodities. 

The dietary burden for cattle and/or swine have not increased significantly from those previously 

calculated. Therefore, the current tolerances in livestock commodities are still appropriate and 

the residue estimates for livestock commodities are as recommended in the previous 

thiamethoxam risk assessment (D348703, M. Doherty, 25 Sept 2008). 
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TABLE 2. INPUT TABLE FOR SELECTED THIAMETHOXAM COMMODITIES. 

RAC Blending Classification Data Source No. of Samples No. of Detectable Residues 

LOD or LOQ (Avg. in PPM) 

Reference Processing Factors (PF)1

Anticipated Residue EstChronic (Tol., AR)2

Artichoke, globe NB/PB FT 6 6 <0.02 

D281702/ D325447 

N/A 0.19 

Barley, grain B FT 16 10 <0.02 

D281702/ D325447 (PF Ref -D281702) 

0.3 pearled 0.3 bran 0.1 flour 

0.086 

Brassica, head and stem, subgroup 5-A NB/PB FT (cabbage) 12 10 <0.02 D281702/ D325447 N/A 0.98 Brassica, leafy greens, subgroup 5-B NB/PB 

FT (mustard greens) 

10 10 <0.02 

D281702/ D325447 

N/A 0.82 

Caneberry subgroup 13-A 

PB FT 12 12 <0.02 

D281702/ D325447 

N/A 0.12 

Citrus, fruits:  Orange  Grapefruit  Lemon 

NB/PB FT 

28 16 12 

27 16 12 

<0.02 D349272 

0.6 oil 0.6 juice 

0.10 0.07 0.09 

Food Handling Establishments NA FT 

42 42 

183

8 

<0.02 D376367 NA 0.01 
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TABLE 2. INPUT TABLE FOR SELECTED THIAMETHOXAM COMMODITIES. 

RAC Blending Classification Data Source No. of Samples No. of Detectable Residues 

LOD or LOQ (Avg. in PPM) 

Reference Processing Factors (PF)1

Anticipated Residue EstChronic (Tol., AR)2

 Fruit, pome, group 11 NB/PB 

FT (apple) FT (pear) 

26 12 

26 10 

<0.02 

D281702/ D325447 & D265079 

0.75 juice 

0.06 0.06 

Fruit, stone, group 12  Cherry  Peach  Plum 

PB NB/PB NB/PB 

FT FT FT 

20 20 20 

20 19 8 

<0.02 W. Cutchin, 12/10/03 DERs 

1 prunes 

0.21 0.07 

0.071 

Grape PB FT 24 22 <0.02 

D281702/ D325447 

1.1 juice 0.06 

Grape, raisin PB FT (grape) 24 22 <0.02 

D281702/ D325447 PF – D281702 

2.3 0.06 

Peanut B FT 54 10 <0.02 D376367 0.31 oil 0.05 Rice B FT 32 1 <0.02 

D357449/ D357450 PF – D357449 

0.9 Polished rice 

0.01 

Soybeans B FT 30 0 <0.02 

D281702/ D325447 

N/A 0.01 

Tree Nuts, group 14 PB FT 12 0 <0.02 D349272 N/A 0.01 
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TABLE 2. INPUT TABLE FOR SELECTED THIAMETHOXAM COMMODITIES. 

RAC Blending Classification Data Source No. of Samples No. of Detectable Residues 

LOD or LOQ (Avg. in PPM) 

Reference Processing Factors (PF)1

Anticipated Residue EstChronic (Tol., AR)2

Tropical Fruits NB FT (avocado) 10 2 <0.02 D357449/ D357450 N/A 0.11 Vegetable, fruiting, group 8 Tomato Pepper 

NB/PB FT 

40 42 

- 42 

<0.02 <0.02 

D281702/ D325447 + D265079 PF – D265079 

Tomato puree 1.7 Tomato paste 3.8 

0.08 0.08 

Vegetable, legume, group 6 

B/PB 

FT Snap beans Lima beans 

16 10 

0 0 

<0.02 

S. Tadayon, 26 Nov 2002 

N/A 0.01 

0.01 

Vegetable, root, subgroup 1A NB/PB Tolerance N/A 

D357449/ D357450 

Potato chips 1.2 Potato flakes 1.7 

0.05 

Water (direct, indirect) N/A EFED N/A N/A N/A N/A N/A Acute= 0.13177 ppm C

1 - The processing factors for existing uses are taken from HED’s June 30, 2009 memo, the sources for these processing factors  reference column. An average processing of 0.31 for peanut oil is the only new processing factor associated with the propo2 - Anticipated residues were calculated using 1⁄2 LOQ for all values below the LOQ. 3- Separate analyses were conducted and reported for thiamethoxam and clothianidin. Each compound has an LOQ of 0.01 pp

LOQ of 0.02 ppm.
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

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3. Drinking Water Data

The drinking water residues used in these dietary risk assessments were provided by EFED 

(D373378, C. Kopert, 20 May 2010), and incorporated directly into the dietary assessments. 

Water residues were incorporated in DEEM-FCID via entry into the food categories “water, 

direct, all sources” and “water, indirect, all sources.” The estimated drinking water 

concentrations (EDWCs) in surface water are 0.13177 ppm and 0.01131 ppm for acute and 

chronic scenarios, respectively. Typically, HED uses the higher of the surface or groundwater 

estimates for each duration when assessing dietary risk, with the surface water (rice tail water) 

having higher values in this case. 

The EDWCs were incorporated into the acute and chronic thiamethoxam assessments. 

Clothianidin, a major metabolite of thiamethoxam in plants and livestock, is not a significant 

degradate of thiamethoxam in surface or groundwater sources of drinking water. 

A Tier II screening-level drinking water assessment was conducted for the proposed new use on 

peanut and alfalfa seeds. EFED also evaluated leafy vegetables, dry bulb onions and corn 

because previous assessments on these commodities were conducted at a lower application rate. 

For surface water, the EDWCs for the crops modeled in this assessment did not exceed the 

previous EDWCs for rice reported in the previous drinking water assessment (D363202, F. 

Khan, 07 April 2009). The reported acute concentration of 131.77 μg/L, annual mean (chronic) 

concentration of 11.31 μg/L and the highest 30 year annual average concentration of 11.31 μg/L 

from the rice model are higher than the reported EDWCs for various uses in Table 3. Therefore, 

the current EDWCs for surface water do not supersede the drinking water concentrations 

previously estimated for this chemical (D363202).

For groundwater, based on the proposed highest annual use rate for dry bulb onions (0.3 lbs 

ai/acre) and the proposed rates for peanut seed (0.08 lbs ai/acre) and alfalfa seed (0.022 lbs 

ai/acre), the SCI-GROW model concentrations of thiamethoxam were 4.66 μg/L, 1.24 μg/L, and 

0.34 μg/L, respectively. This value was compared to 4.14 μg/L reported for grapes in an earlier 

drinking water assessment (D329467) dated 10 January 2007. Since 4.66 μg/L for dry bulb 

onions is greater than 4.14 μg/L, the current EDWC supercedes the previously recommended 

EDWC for groundwater. 

The acute scenario EDWC in surface water (0.13177 ppm) was obtained via exposure modeling 

which utilized a modified Tier I Rice Model and the Provisional Cranberry Model. This model 

and its description are available at the EPA internet website via the web link, 

http://www.epa.gov/oppefed1/models/water/. 
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Table 3. Tier II Estimated Drinking Water Concentrations (EDWCs) resulting from applications of 

Thiamethoxam. 

Drinking Water 

Source (model) 

Use 

Scenario 

(modeled rate) 

1-in-10 year acute

(μg/L)

1-in-10 year chronic 

(μg/L)

30- year average 

(μg/L) 

Surface Water 

(PRZM/EXAMS) 

NC Peanuts:

(1 app.1

 X 0.08 lbs ai/acre) 

1.51 0.16 0.05 

CA Alfalfa 

(January 9) 

MN Alfalfa 

(May 25) 

NC Alfalfa 

(March 25) 

PA Alfalfa 

(March 9) 

TX Alfalfa 

(August 25) 

IL Alfalfa 

(May 25) 

(all were 1 app. X 0.022 

lbs. ai/acre) 

0.37 

0.27 

0.55 

0.37 

0.89 

0.58 

0.07 

0.03 

0.08 

0.05 

0.10 

0.06 

0.03 

0.02 

0.03 

0.03 

0.05 

0.03 

Dry Bulb Onions:

CA Onion 

GA Onion 

(1 app. X 0.3 lbs ai/acre) 

1.57 

20.45 

0.25 

1.54 

0.06 

0.44 

Leafy Vegetables:

CA Lettuce (1 run) 

(1 app. X 0.266 lbs. ai/acre)

23.78 3.68 1.29 

Tail water 

(Rice Model) 

Rice 

(0.173 lbs ai/A/year)

131.771,2 11.311,3 11.311,3

Cranberry 

(0.188 lbs ai/A/year)

54.752 4.503 4.503

Groundwater 

(SCI-GROW) 

Peanuts:

(1 app. X 0.08 lbs ai/acre) 

1.24 1.24 1.24 

Alfalfa:

(1 app. X 0.022 lbs. ai/acre)

0.34 0.34 0.34 

Dry bulb onions:

(1 app. X 0.30 lbs. ai/acre) 

4.66 4.66 4.66 

Bold text denotes maximum estimated EDWC values. All values adjusted with PCA factor of 0.87. 

1 Recommended EDWCs for surface water. 

2 EDWCs based on day 1. 

3 EWDCs based on average of 365 days. 
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Water Monitoring Data 

Only very limited monitoring data are available for thiamethoxam and these data are discussed 

below; due to this limitation HED used modeling data for the drinking water residue estimate for 

both the acute and chronic dietary risk assessments. 

Two small-scale prospective groundwater (PGW) monitoring studies were initiated in southwest 

Michigan in June 2001 and southwestern Georgia in the spring of 2002, to determine the 

potential for the active ingredient thiamethoxam and its degradates to reach groundwater when 

used in a vulnerable hydrogeologic setting. Analytical data were collected for 47 months (from 

treatment in the spring of 2001 until May 2005) in the Michigan study and for 36 months (from 

treatment in the spring of 2002 until May 2005) in the Georgia study. 

In Michigan, thiamethoxam residues found in soil-pore water samples have clearly peaked and 

then declined. No quantifiable residues of thiamethoxam > LOQ (0.05 ppb) were observed in any 

of the 3, 6, and 9-ft lysimeters after the 36, 16, and 41-MAT sampling events, respectively. By 

the 47-MAT sampling event only trace level detections of thiamethoxam were observed in three 

of the 15-ft. lysimeter units (maximum concentration 0.11 ppb). 

In Georgia, thiamethoxam residues have only been confirmed in four shallow monitoring wells 

(MW-1S, MW-3S, MW-5S, and MW-8S) during 47 months of sampling. Thiamethoxam 

residues in groundwater peaked at 43-MAT, and by 47-MAT residues were confined to two 

shallow monitoring wells only (maximum concentration 0.12 ppb). No detections of 

thiamethoxam at or greater than the analytical method LOQ have been observed in any 

groundwater samples collected from the deep monitoring wells during 47 months of sampling. 

4. DEEM-FCIDTM Program and Consumption Information

Thiamethoxam acute and chronic dietary exposure assessments were conducted using DEEMFCIDTM (Version 2.03), which incorporates consumption data from USDA’s CSFII, 1994 to 

1996, and 1998. The 1994-96, 1998 data are based on the reported consumption of more than 

20,000 individuals over two non-consecutive survey days. Foods “as consumed” (such as apple 

pie) are linked to EPA-defined food commodities (such as apples, peeled fruit - cooked, 

fresh/unspecified, or baked; or wheat flour - cooked, fresh/unspecified, or baked) using publicly 

available recipe translation files developed jointly by USDA/ARS and EPA. For chronic 

exposure assessment, consumption data are averaged for the entire US population, and within 

population subgroups, but for acute exposure assessment, they are retained as individual 

consumption events (which is why it is appropriate to add residue values together for the acute 

assessment, while separate exposure estimates are summed for the chronic assessment). Based 

on analysis of the 1994-96, 1998 CSFII consumption data, which took into account dietary 

patterns and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general US population, all infants (<1 year old), children 1-

2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years 

old. 
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For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (such as orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form. The resulting residue consumption 

estimate for each food/food form is summed with the residue consumption estimates for all other 

food/food forms on the commodity residue list to arrive at the total average estimated exposure. 

Exposure is expressed in mg/kg body weight/day, and as a percent of the cPAD. This procedure 

is performed for each population subgroup. 

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate, and summed to obtain a total daily pesticide exposure for 

a deterministic exposure assessment, or “matched” in multiple random pairings with residue 

values, and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (those who reported eating relevant 

commodities/food forms) and a per-capita (those who reported eating the relevant commodities 

as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk 

are reported for all tiers of analysis. However, for Tiers 1 and 2, significant differences in user 

versus per capita exposure and risk are identified, and noted in the risk assessment. 

5. Toxicological Information 

The toxicology database for thiamethoxam is complete. The scientific quality is relatively high 

and the toxicity profile of thiamethoxam can be characterized for most effects, including 

potential carcinogenic, mutagenic, developmental, and neurotoxic effects. 

The Agency has determined that the 10X FQPA safety factor for the protection of infants and 

children can be reduced to 1X. There is no quantitative or qualitative evidence of increased 

susceptibility of rat or rabbit fetuses to in utero exposure to thiamethoxam in the developmental 

toxicity studies. The developmental NOAELs are either higher than or equal to the maternal 

NOAELs. The Developmental Neurotoxity (DNT) Workgroup concluded there was no evidence 

of increased quantitative susceptibility in the DNT study in rats, based on evaluation of 

additional brain morphometric data for the low- and mid-dose pups (January 17, 2007 meeting). 

 

Although there is evidence of increased quantitative susceptibility for male pups of both two 

generation reproductive studies, NOAELs and LOAELs were established in these studies, and 

the Agency selected the NOAEL for testicular effects in F1 pups as the basis for risk assessment. 

The Agency is confident that the NOAEL selected for risk assessment is protective of the most 

sensitive effect (testicular effects) for the most sensitive subgroup (pups) observed in the 

toxicological database. 

 

In addition, the NOAELs selected for risk assessment are protective of all toxicological effects 

observed in the database including treatment-related changes in the adrenal gland, thyroid, testes 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

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and ovaries. Thus, the Agency believes the FQPA safety factor can be reduced to 1X and still be 

conservatively protective of human health risk. 

Table 4. Toxicological Doses and Endpoints for Thiamethoxam for Use in Human Health Risk Assessments. 

Exposure/ 

Scenario 

Point of 

Departure 

Uncertainty/ FQPA 

Safety Factors 

Level of Concern 

for Risk 

Assessment 

Study and Toxicological Effects 

Acute Dietary 

All populations

including 

infants and 

children 

NOAEL = 

34.5 

mg/kg/day 

UFA= 10x 

UFH= 10x 

SFFQPA=1 

aRfD=0.35 

mg/kg/day 

aPAD=0.35 

mg/kg/day 

Rat Developmental Neurotoxicity 

study 

LOAEL = 298.7 mg/kg/day based 

on delayed sexual maturation in 

male pups, and reduced brain 

morphometric measurements. 

Chronic Dietary 

All populations

including 

infants and 

children 

NOAEL= 1.2 

mg/kg/day 

(MRID 

46402904)

UFA= 10x 

UFH= 10x 

SFFQPA=1 

cRfD=0.012 

mg/kg/day 

cPAD=0.012 

mg/kg/day 

2-Generation reproduction study

LOAEL = 1.8 mg/kg/day based on 

increased incidence and severity of 

tubular atrophy in testes of F1 

generation males. 

2-Generation reproduction study 

(46402904) 

LOAEL = 3 (males), not determined 

(females) mg/kg/day based on 

sperm abnormalities in F1 males. 

Cancer (oral, 

dermal, 

inhalation) 

“Not Likely to be Carcinogenic to Humans” based on convincing evidence that a nongenotoxic mode of action for liver tumors was established in the mouse and that the carcinogenic 

effects are a result of a mode of action dependent on sufficient amounts of a hepatotoxic 

metabolite produced persistently. Quantification of cancer risk is not required. 

6. Results/Discussion

As previously stated, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the 

US population and various population subgroups. The results of the assessments are shown in 

Table 5, below. 

 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 14 of 33 

Table 5. Summary of Estimated Dietary (Food + Drinking Water) Exposures and Risk for Thiamethoxam. 

Population Subgroup aPAD, 

mg/kg/day 

Acute Estimates (95th

Percentile)1 cPAD, 

mg/kg/day 

Chronic Estimates 

Exposure, 

mg/kg/day Risk, % aPAD Exposure, mg/kg/day Risk, % cPAD 

U.S. Population 0.35 0.018094 5.2 0.012 0.002825 24 

All infants (< 1 year)2 0.35 0.033165 9.5 0.012 0.003052 25 

Children 1-2 yrs 0.35 0.032947 9.4 0.012 0.005150 43 

Children 3-5 yrs 0.35 0.026627 7.6 0.012 0.004520 38 

Children 6-12 yrs 0.35 0.018819 5.4 0.012 0.003241 27 

Youth 13-19 yrs 0.35 0.014311 4.1 0.012 0.002333 19 

Adults 20-49 yrs 0.35 0.016277 4.7 0.012 0.002591 22 

Adults 50+ yrs 0.35 0.016617 4.8 0.012 0.002648 22 

Females 13-49 yrs 0.35 0.16123 4.6 0.012 0.002617 22 

1 - Results for the 99th and 99.9th percentile are reported in Attachment 3. 

2 - The population subgroup with the highest estimated exposure/risk is bolded. 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. 

population and various population subgroups. The results reported in Table 5 are for the general 

U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50+ years. The acute results summarized in Table 6 are 

for the 95th percentile of exposure. A complete listing of acute and chronic exposure and risk 

estimates can be found in Attachments 2 and 3, respectively. 

The analyses indicate that the requested uses of thiamethoxam, coupled with currently registered 

uses, will result in acute and chronic dietary (food + drinking water) exposures that are below 

HED’s level of concern for all population subgroups, including those of infants and children. 

Typically, HED uses tolerance-level residues in its most conservative assessments. For this 

reason, the acute assessment is considered to be an unrefined assessment (i.e., screening level) 

and evaluation at the 95th percentile of exposure is appropriate. The acute assessment indicates 

that All Infants are the most highly-exposed subgroup, utilizing 9.5% of the aPAD, while the 

general US population utilizes 5.2% of the aPAD; all risk estimates are below HED’s level of 

concern (Table 5). Similarly, risk estimates for the chronic dietary exposure analysis are below 

HED’s level of concern, with Children 1-2 years being the most highly-exposed subgroup, 

utilizing 43% of the chronic population-adjusted dose (cPAD), while the general U.S. population 

utilizes 24% of the cPAD. 

7. Characterization of Inputs/Outputs

This assessment is based on tolerance level or anticipated residues derived from field trial 

residue data and assumes 100% CT. The exposure values represent high-end estimates and 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 15 of 33 

should be considered highly conservative, health-protective estimates of dietary exposure and 

risk. The Tier I Rice Model used to generate the EDWCs is expected to generate conservative 

estimates that exceed peak measured concentrations of pesticides in water bodies well 

downstream of rice paddies by less than one order of magnitude to multiple orders of magnitude. 

8. Conclusions

Based on highly conservative assumptions, there are no dietary (food + drinking water) exposure 

considerations that would preclude registration of thiamethoxam on alfalfa, peanuts and/or use in 

food handling establishments. 

9. List of Attachments 

Attachment 1. Input file for the acute dietary exposure analyses of thiamethoxam. 

Attachment 2. Input file for the chronic dietary exposure analyses of thiamethoxam. 

Attachment 3. Summary of the acute dietary exposure analysis for thiamethoxam. 

Attachment 4. Summary of the chronic dietary exposure analysis for thiamethoxam. 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 16 of 33 

Attachment 1. Input File for the Acute Dietary Exposure Estimates. 

U.S. Environmental Protection Agency Ver. 2.02 

DEEM-FCID Acute analysis for THIAMETHOXAM 

Residue file name: C:\Documents and Settings\dmcneill\My 

Documents\Thiamethoxam_3\060109 2010 Acute T+Water.R98 

Analysis Date 10-28-2010 Residue file dated: 10-28-2010/09:42:38 

Reference dose (aRfD) = 0.35 mg/kg bw/day 

Comment: Acute and Chronic RfDs = aPAD and cPAD 

-------------------------------------------------------------------------------- 

 EPA Crop Def Res Adj.Factors Comment 

 Code Grp Food Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ ------- 

14000030 14 Almond 0.020000 1.000 1.000 

14000031 14 Almond-babyfood 0.020000 1.000 1.000 

14000040 14 Almond, oil 0.020000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.020000 1.000 1.000 

04010050 4A Amaranth, leafy 4.000000 1.000 1.000 

11000070 11 Apple, fruit with peel 0.200000 1.000 1.000 

11000080 11 Apple, peeled fruit 0.200000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 0.200000 1.000 1.000 

11000090 11 Apple, dried 0.200000 8.000 1.000 

11000091 11 Apple, dried-babyfood 0.200000 8.000 1.000 

11000100 11 Apple, juice 0.200000 0.750 1.000 

11000101 11 Apple, juice-babyfood 0.200000 0.750 1.000 

11000110 11 Apple, sauce 0.200000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 0.200000 1.000 1.000 

12000120 12 Apricot 0.500000 1.000 1.000 

12000121 12 Apricot-babyfood 0.500000 1.000 1.000 

12000130 12 Apricot, dried 0.500000 6.000 1.000 

12000140 12 Apricot, juice 0.500000 1.000 1.000 

12000141 12 Apricot, juice-babyfood 0.500000 1.000 1.000 

95000160 O Artichoke, globe 0.450000 1.000 1.000 

04010180 4A Arugula 4.000000 1.000 1.000 

95000200 O Avocado 0.400000 1.000 1.000 

09020210 9B Balsam pear 0.200000 1.000 1.000 

15000250 15 Barley, pearled barley 0.300000 0.300 1.000 

 Full comment: D281702 

15000251 15 Barley, pearled barley-babyfood 0.300000 0.300 1.000 

 Full comment: D281702 

15000260 15 Barley, flour 0.300000 0.100 1.000 

 Full comment: D281702 

15000261 15 Barley, flour-babyfood 0.300000 0.100 1.000 

 Full comment: D281702 

15000270 15 Barley, bran 0.300000 0.300 1.000 

 Full comment: D281702 

06030300 6C Bean, black, seed 0.020000 1.000 1.000 

06020310 6B Bean, broad, succulent 0.020000 1.000 1.000 

06030320 6C Bean, broad, seed 0.020000 1.000 1.000 

06020330 6B Bean, cowpea, succulent 0.020000 1.000 1.000 

06030340 6C Bean, cowpea, seed 0.020000 1.000 1.000 

06030350 6C Bean, great northern, seed 0.020000 1.000 1.000 

06030360 6C Bean, kidney, seed 0.020000 1.000 1.000 

06020370 6B Bean, lima, succulent 0.020000 1.000 1.000 

06030380 6C Bean, lima, seed 0.020000 1.000 1.000 

06030390 6C Bean, mung, seed 0.020000 1.000 1.000 

06030400 6C Bean, navy, seed 0.020000 1.000 1.000 

06030410 6C Bean, pink, seed 0.020000 1.000 1.000 

06030420 6C Bean, pinto, seed 0.020000 1.000 1.000 

06010430 6A Bean, snap, succulent 0.020000 1.000 1.000 

06010431 6A Bean, snap, succulent-babyfood 0.020000 1.000 1.000 

21000440 M Beef, meat 0.020000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.020000 1.000 1.000 

21000450 M Beef, meat, dried 0.020000 1.920 1.000 

21000460 M Beef, meat byproducts 0.040000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.040000 1.000 1.000 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 17 of 33 

21000480 M Beef, kidney 0.040000 1.000 1.000 

21000490 M Beef, liver 0.040000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.040000 1.000 1.000 

01010500 1AB Beet, garden, roots 0.050000 1.000 1.000 

 Full comment: D357449, recommended tol. 

01010501 1AB Beet, garden, roots-babyfood 0.050000 1.000 1.000 

01010520 1A Beet, sugar 0.050000 1.000 1.000 

01010521 1A Beet, sugar-babyfood 0.050000 1.000 1.000 

01010530 1A Beet, sugar, molasses 0.050000 1.000 1.000 

01010531 1A Beet, sugar, molasses-babyfood 0.050000 1.000 1.000 

13010550 13A Blackberry 0.350000 1.000 1.000 

13010560 13A Blackberry, juice 0.350000 1.000 1.000 

13010561 13A Blackberry, juice-babyfood 0.350000 1.000 1.000 

13020570 13B Blueberry 0.300000 1.000 1.000 

13020571 13B Blueberry-babyfood 0.300000 1.000 1.000 

13010580 13A Boysenberry 0.350000 1.000 1.000 

14000590 14 Brazil nut 0.020000 1.000 1.000 

05010610 5A Broccoli 4.500000 1.000 1.000 

05010611 5A Broccoli-babyfood 4.500000 1.000 1.000 

05010620 5A Broccoli, Chinese 4.500000 1.000 1.000 

05020630 5B Broccoli raab 3.000000 1.000 1.000 

05010640 5A Brussels sprouts 4.500000 1.000 1.000 

15000650 15 Buckwheat 0.020000 1.000 1.000 

15000660 15 Buckwheat, flour 0.020000 1.000 1.000 

01010670 1AB Burdock 0.050000 1.000 1.000 

14000680 14 Butternut 0.020000 1.000 1.000 

05010690 5A Cabbage 4.500000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 3.000000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 4.500000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 4.500000 1.000 1.000 

95000740 O Canistel 0.400000 1.000 1.000 

09010750 9A Cantaloupe 0.200000 1.000 1.000 

04020760 4B Cardoon 4.000000 1.000 1.000 

01010780 1AB Carrot 0.050000 1.000 1.000 

01010781 1AB Carrot-babyfood 0.050000 1.000 1.000 

01010790 1AB Carrot, juice 0.050000 1.000 1.000 

09010800 9A Casaba 0.200000 1.000 1.000 

14000810 14 Cashew 0.020000 1.000 1.000 

05010830 5A Cauliflower 4.500000 1.000 1.000 

01010840 1AB Celeriac 0.050000 1.000 1.000 

04020850 4B Celery 4.000000 1.000 1.000 

04020851 4B Celery-babyfood 4.000000 1.000 1.000 

04020860 4B Celery, juice 4.000000 1.000 1.000 

04020870 4B Celtuce 4.000000 1.000 1.000 

09020880 9B Chayote, fruit 0.200000 1.000 1.000 

95000890 O Cherimoya 0.110000 1.000 1.000 

12000900 12 Cherry 0.500000 1.000 1.000 

12000901 12 Cherry-babyfood 0.500000 1.000 1.000 

12000910 12 Cherry, juice 0.500000 1.500 1.000 

12000911 12 Cherry, juice-babyfood 0.500000 1.500 1.000 

14000920 14 Chestnut 0.020000 1.000 1.000 

06030980 6C Chickpea, seed 0.020000 1.000 1.000 

06030981 6C Chickpea, seed-babyfood 0.020000 1.000 1.000 

06030990 6C Chickpea, flour 0.020000 1.000 1.000 

01011000 1AB Chicory, roots 0.050000 1.000 1.000 

09021020 9B Chinese waxgourd 0.200000 1.000 1.000 

04011040 4A Chrysanthemum, garland 4.000000 1.000 1.000 

10001060 10 Citrus citron 0.400000 1.000 1.000 

 Full comment: D348703 

10001070 10 Citrus hybrids 0.400000 1.000 1.000 

10001080 10 Citrus, oil 0.400000 0.600 1.000 

 Full comment: D349272 

95001150 O Coffee, roasted bean 0.050000 1.000 1.000 

95001160 O Coffee, instant 0.050000 1.000 1.000 

05021170 5B Collards 3.000000 1.000 1.000 

15001200 15 Corn, field, flour 0.020000 1.000 1.000 

15001201 15 Corn, field, flour-babyfood 0.020000 1.000 1.000 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 18 of 33 

15001210 15 Corn, field, meal 0.020000 1.000 1.000 

15001211 15 Corn, field, meal-babyfood 0.020000 1.000 1.000 

15001220 15 Corn, field, bran 0.020000 1.000 1.000 

15001230 15 Corn, field, starch 0.020000 1.000 1.000 

15001231 15 Corn, field, starch-babyfood 0.020000 1.000 1.000 

15001240 15 Corn, field, syrup 0.020000 1.500 1.000 

15001241 15 Corn, field, syrup-babyfood 0.020000 1.500 1.000 

15001250 15 Corn, field, oil 0.020000 1.000 1.000 

15001251 15 Corn, field, oil-babyfood 0.020000 1.000 1.000 

15001260 15 Corn, pop 0.020000 1.000 1.000 

15001270 15 Corn, sweet 0.020000 1.000 1.000 

15001271 15 Corn, sweet-babyfood 0.020000 1.000 1.000 

95001280 O Cottonseed, oil 0.100000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.100000 1.000 1.000 

11001290 11 Crabapple 0.200000 1.000 1.000 

95001300 O Cranberry 0.020000 1.000 1.000 

95001301 O Cranberry-babyfood 0.020000 1.000 1.000 

95001310 O Cranberry, dried 0.020000 1.000 1.000 

95001320 O Cranberry, juice 0.020000 1.100 1.000 

95001321 O Cranberry, juice-babyfood 0.020000 1.100 1.000 

04011330 4A Cress, garden 4.000000 1.000 1.000 

04011340 4A Cress, upland 4.000000 1.000 1.000 

09021350 9B Cucumber 0.200000 1.000 1.000 

13021360 13B Currant 0.200000 1.000 1.000 

13021370 13B Currant, dried 0.200000 1.000 1.000 

04011380 4A Dandelion, leaves 4.000000 1.000 1.000 

13011420 13A Dewberry 0.350000 1.000 1.000 

08001480 8 Eggplant 0.250000 1.000 1.000 

13021490 13B Elderberry 0.200000 1.000 1.000 

04011500 4A Endive 4.000000 1.000 1.000 

04021520 4B Fennel, Florence 4.000000 1.000 1.000 

14001550 14 Filbert 0.020000 1.000 1.000 

14001560 14 Filbert, oil 0.020000 1.000 1.000 

20001630 20 Flaxseed, oil 0.020000 1.000 1.000 

01011680 1AB Ginseng, dried 0.050000 1.000 1.000 

23001690 M Goat, meat 0.020000 1.000 1.000 

23001700 M Goat, meat byproducts 0.040000 1.000 1.000 

23001720 M Goat, kidney 0.040000 1.000 1.000 

23001730 M Goat, liver 0.040000 1.000 1.000 

13021740 13B Gooseberry 0.200000 1.000 1.000 

95001750 O Grape 0.200000 1.000 1.000 

95001760 O Grape, juice 0.200000 1.100 1.000 

 Full comment: D281702 

95001761 O Grape, juice-babyfood 0.200000 1.100 1.000 

95001770 O Grape, leaves 0.200000 1.000 1.000 

95001780 O Grape, raisin 0.200000 2.300 1.000 

 Full comment: D281702 

95001790 O Grape, wine and sherry 0.200000 1.000 1.000 

10001800 10 Grapefruit 0.400000 1.000 1.000 

10001810 10 Grapefruit, juice 0.400000 0.600 1.000 

 Full comment: D349272 

06031820 6C Guar, seed 0.020000 1.000 1.000 

06031821 6C Guar, seed-babyfood 0.020000 1.000 1.000 

14001850 14 Hickory nut 0.020000 1.000 1.000 

09011870 9A Honeydew melon 0.200000 1.000 1.000 

95001880 O Hop 0.100000 1.000 1.000 

24001890 M Horse, meat 0.020000 1.000 1.000 

01011900 1AB Horseradish 0.050000 1.000 1.000 

13021910 13B Huckleberry 0.200000 1.000 1.000 

05021940 5B Kale 3.000000 1.000 1.000 

05011960 5A Kohlrabi 4.500000 1.000 1.000 

10001970 10 Kumquat 0.400000 1.000 1.000 

10001990 10 Lemon 0.400000 1.000 1.000 

10002000 10 Lemon, juice 0.400000 0.600 1.000 

 Full comment: D348272 

10002001 10 Lemon, juice-babyfood 0.400000 0.600 1.000 

 Full comment: D349272 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 19 of 33 

10002010 10 Lemon, peel 0.400000 1.000 1.000 

06032030 6C Lentil, seed 0.020000 1.000 1.000 

04012040 4A Lettuce, head 4.000000 1.000 1.000 

04012050 4A Lettuce, leaf 4.000000 1.000 1.000 

10002060 10 Lime 0.400000 1.000 1.000 

10002070 10 Lime, juice 0.400000 0.600 1.000 

 Full comment: D348272 

10002071 10 Lime, juice-babyfood 0.400000 0.600 1.000 

 Full comment: D349272 

13012080 13A Loganberry 0.350000 1.000 1.000 

11002100 11 Loquat 0.200000 1.000 1.000 

14002130 14 Macadamia nut 0.020000 1.000 1.000 

95002150 O Mango 0.400000 1.000 1.000 

95002151 O Mango-babyfood 0.400000 1.000 1.000 

95002160 O Mango, dried 0.400000 1.000 1.000 

95002170 O Mango, juice 0.400000 1.000 1.000 

95002171 O Mango, juice-babyfood 0.400000 1.000 1.000 

28002210 M Meat, game 0.020000 1.000 1.000 

27002220 D Milk, fat 0.020000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.020000 1.000 1.000 

27012230 D Milk, nonfat solids 0.020000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.020000 1.000 1.000 

27022240 D Milk, water 0.020000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.020000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.020000 1.000 1.000 

15002260 15 Millet, grain 0.020000 1.000 1.000 

05022290 5B Mustard greens 3.000000 1.000 1.000 

12002300 12 Nectarine 0.500000 1.000 1.000 

15002310 15 Oat, bran 0.020000 1.000 1.000 

15002320 15 Oat, flour 0.020000 1.000 1.000 

15002321 15 Oat, flour-babyfood 0.020000 1.000 1.000 

15002330 15 Oat, groats/rolled oats 0.020000 1.000 1.000 

15002331 15 Oat, groats/rolled oats-babyfood 0.020000 1.000 1.000 

08002340 8 Okra 0.250000 1.000 1.000 

03002370 3 Onion, dry bulb 0.030000 1.000 1.000 

03002371 3 Onion, dry bulb-babyfood 0.030000 1.000 1.000 

03002380 3 Onion, dry bulb, dried 0.030000 9.000 1.000 

03002381 3 Onion, dry bulb, dried-babyfood 0.030000 9.000 1.000 

10002400 10 Orange 0.400000 1.000 1.000 

10002410 10 Orange, juice 0.400000 0.600 1.000 

 Full comment: D349272 

10002411 10 Orange, juice-babyfood 0.400000 0.600 1.000 

 Full comment: D348272 

10002420 10 Orange, peel 0.400000 1.000 1.000 

95002450 O Papaya 0.400000 1.000 1.000 

95002451 O Papaya-babyfood 0.400000 1.000 1.000 

95002460 O Papaya, dried 0.400000 1.800 1.000 

95002470 O Papaya, juice 0.400000 1.500 1.000 

04012480 4A Parsley, leaves 4.000000 1.000 1.000 

01012500 1AB Parsley, turnip rooted 0.050000 1.000 1.000 

01012510 1AB Parsnip 0.050000 1.000 1.000 

01012511 1AB Parsnip-babyfood 0.050000 1.000 1.000 

06022550 6B Pea, succulent 0.020000 1.000 1.000 

06022551 6B Pea, succulent-babyfood 0.020000 1.000 1.000 

06032560 6C Pea, dry 0.020000 1.000 1.000 

06032561 6C Pea, dry-babyfood 0.020000 1.000 1.000 

06012570 6A Pea, edible podded, succulent 0.020000 1.000 1.000 

06032580 6C Pea, pigeon, seed 0.020000 1.000 1.000 

06022590 6B Pea, pigeon, succulent 0.020000 1.000 1.000 

12002600 12 Peach 0.500000 1.000 1.000 

12002601 12 Peach-babyfood 0.500000 1.000 1.000 

12002610 12 Peach, dried 0.500000 7.000 1.000 

12002611 12 Peach, dried-babyfood 0.500000 7.000 1.000 

12002620 12 Peach, juice 0.500000 1.000 1.000 

12002621 12 Peach, juice-babyfood 0.500000 1.000 1.000 

95002630 O Peanut 0.050000 1.000 1.000 

95002640 O Peanut, butter 0.050000 1.890 1.000 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 20 of 33 

95002650 O Peanut, oil 0.050000 0.310 1.000 

 Full comment: D376367 

11002660 11 Pear 0.200000 1.000 1.000 

11002661 11 Pear-babyfood 0.200000 1.000 1.000 

11002670 11 Pear, dried 0.200000 6.250 1.000 

11002680 11 Pear, juice 0.200000 1.000 1.000 

11002681 11 Pear, juice-babyfood 0.200000 1.000 1.000 

14002690 14 Pecan 0.020000 1.000 1.000 

08002700 8 Pepper, bell 0.250000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.250000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.250000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.250000 1.000 1.000 

08002720 8 Pepper, nonbell 0.250000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.250000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.250000 1.000 1.000 

95002750 O Peppermint 1.500000 1.000 1.000 

95002760 O Peppermint, oil 1.500000 0.050 1.000 

14002820 14 Pistachio 0.020000 1.000 1.000 

12002850 12 Plum 0.500000 1.000 1.000 

12002851 12 Plum-babyfood 0.500000 1.000 1.000 

12002860 12 Plum, prune, fresh 0.500000 1.000 1.000 

12002861 12 Plum, prune, fresh-babyfood 0.500000 1.000 1.000 

12002870 12 Plum, prune, dried 0.500000 5.000 1.000 

12002871 12 Plum, prune, dried-babyfood 0.500000 5.000 1.000 

12002880 12 Plum, prune, juice 0.500000 1.400 1.000 

12002881 12 Plum, prune, juice-babyfood 0.500000 1.400 1.000 

25002900 M Pork, meat 0.020000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.020000 1.000 1.000 

25002920 M Pork, meat byproducts 0.020000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.020000 1.000 1.000 

25002940 M Pork, kidney 0.020000 1.000 1.000 

25002950 M Pork, liver 0.020000 1.000 1.000 

01032960 1C Potato, chips 0.250000 1.200 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.250000 1.700 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.250000 1.700 1.000 

01032980 1C Potato, flour 0.250000 1.700 1.000 

01032981 1C Potato, flour-babyfood 0.250000 1.700 1.000 

01032990 1C Potato, tuber, w/peel 0.250000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.250000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.250000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.250000 1.000 1.000 

10003070 10 Pummelo 0.400000 1.000 1.000 

09023080 9B Pumpkin 0.200000 1.000 1.000 

09023090 9B Pumpkin, seed 0.200000 1.000 1.000 

11003100 11 Quince 0.200000 1.000 1.000 

29003120 M Rabbit, meat 0.020000 1.000 1.000 

04013130 4A Radicchio 4.000000 1.000 1.000 

01013140 1AB Radish, roots 0.050000 1.000 1.000 

02003150 2 Radish, tops 0.800000 1.000 1.000 

01013160 1AB Radish, Oriental, roots 0.050000 1.000 1.000 

02003170 2 Radish, Oriental, tops 0.800000 1.000 1.000 

05023180 5B Rape greens 3.000000 1.000 1.000 

20003190 20 Rapeseed, oil 0.020000 1.000 1.000 

20003191 20 Rapeseed, oil-babyfood 0.020000 1.000 1.000 

13013200 13A Raspberry 0.350000 1.000 1.000 

13013201 13A Raspberry-babyfood 0.350000 1.000 1.000 

13013210 13A Raspberry, juice 0.350000 1.000 1.000 

13013211 13A Raspberry, juice-babyfood 0.350000 1.000 1.000 

04023220 4B Rhubarb 4.000000 1.000 1.000 

15003230 15 Rice, white 0.020000 1.000 1.000 

15003231 15 Rice, white-babyfood 0.020000 1.000 1.000 

15003240 15 Rice, brown 0.020000 1.000 1.000 

15003241 15 Rice, brown-babyfood 0.020000 1.000 1.000 

15003250 15 Rice, flour 0.020000 1.000 1.000 

15003251 15 Rice, flour-babyfood 0.020000 1.000 1.000 

15003260 15 Rice, bran 0.020000 0.900 1.000 

 Full comment: D357449 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 21 of 33 

15003261 15 Rice, bran-babyfood 0.020000 0.900 1.000 

 Full comment: D357449 

01013270 1AB Rutabaga 0.050000 1.000 1.000 

15003280 15 Rye, grain 0.020000 1.000 1.000 

15003290 15 Rye, flour 0.020000 1.000 1.000 

20003300 20 Safflower, oil 0.020000 1.000 1.000 

20003301 20 Safflower, oil-babyfood 0.020000 1.000 1.000 

01013310 1AB Salsify, roots 0.050000 1.000 1.000 

95003330 O Sapote, Mamey 0.400000 1.000 1.000 

26003390 M Sheep, meat 0.020000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.020000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.040000 1.000 1.000 

26003420 M Sheep, kidney 0.040000 1.000 1.000 

26003430 M Sheep, liver 0.040000 1.000 1.000 

15003440 15 Sorghum, grain 0.020000 1.000 1.000 

15003450 15 Sorghum, syrup 0.020000 1.000 1.000 

06003470 6 Soybean, seed 0.020000 1.000 1.000 

06003480 6 Soybean, flour 0.020000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.020000 1.000 1.000 

06003490 6 Soybean, soy milk 0.020000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.020000 1.000 1.000 

06003500 6 Soybean, oil 0.020000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.020000 1.000 1.000 

95003520 O Spearmint 1.500000 1.000 1.000 

95003530 O Spearmint, oil 1.500000 0.050 1.000 

 Full comment: D281702 

04013550 4A Spinach 4.000000 1.000 1.000 

04013551 4A Spinach-babyfood 4.000000 1.000 1.000 

09023560 9B Squash, summer 0.200000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.200000 1.000 1.000 

09023570 9B Squash, winter 0.200000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.200000 1.000 1.000 

95003590 O Strawberry 0.300000 1.000 1.000 

95003591 O Strawberry-babyfood 0.300000 1.000 1.000 

95003600 O Strawberry, juice 0.300000 1.000 1.000 

95003601 O Strawberry, juice-babyfood 0.300000 1.000 1.000 

20003640 20 Sunflower, seed 0.020000 1.000 1.000 

20003650 20 Sunflower, oil 0.020000 1.000 1.000 

20003651 20 Sunflower, oil-babyfood 0.020000 1.000 1.000 

01033660 1CD Sweet potato 0.020000 1.000 1.000 

01033661 1CD Sweet potato-babyfood 0.020000 1.000 1.000 

04023670 4B Swiss chard 4.000000 1.000 1.000 

10003690 10 Tangerine 0.400000 1.000 1.000 

10003700 10 Tangerine, juice 0.400000 0.600 1.000 

 Full comment: D348272 

01033710 1CD Tanier, corm 0.020000 1.000 1.000 

08003740 8 Tomatillo 0.250000 1.000 1.000 

08003750 8 Tomato 0.250000 1.000 1.000 

08003751 8 Tomato-babyfood 0.250000 1.000 1.000 

08003760 8 Tomato, paste 0.800000 1.000 1.000 Tol. 

08003761 8 Tomato, paste-babyfood 0.800000 1.000 1.000 Tol. 

08003770 8 Tomato, puree 0.250000 1.700 1.000 

08003771 8 Tomato, puree-babyfood 0.250000 1.700 1.000 

08003780 8 Tomato, dried 0.250000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.250000 14.300 1.000 

08003790 8 Tomato, juice 0.250000 1.500 1.000 

15003810 15 Triticale, flour 0.020000 1.000 1.000 

15003811 15 Triticale, flour-babyfood 0.020000 1.000 1.000 

01033870 1CD Turmeric 0.020000 1.000 1.000 

01013880 1AB Turnip, roots 0.050000 1.000 1.000 

05023890 5B Turnip, greens 3.000000 1.000 1.000 

14003910 14 Walnut 0.020000 1.000 1.000 

86010000 O Water, direct, all sources 0.131770 1.000 1.000 

 Full comment: D373378 

86020000 O Water, indirect, all sources 0.131770 1.000 1.000 

 Full comment: D373378 

09013990 9A Watermelon 0.200000 1.000 1.000 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 22 of 33 

09014000 9A Watermelon, juice 0.200000 1.000 1.000 

15004010 15 Wheat, grain 0.020000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.020000 1.000 1.000 

15004020 15 Wheat, flour 0.020000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.020000 1.000 1.000 

15004030 15 Wheat, germ 0.020000 1.000 1.000 

15004040 15 Wheat, bran 0.020000 1.000 1.000 

15004050 15 Wild rice 0.020000 1.000 1.000 

01034060 1CD Yam, true 0.020000 1.000 1.000 

01034070 1CD Yam bean 0.020000 1.000 1.000
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 23 of 33 

Attachment 2. Input File for the Chronic Dietary Exposure 

Estimates. 

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for THIAMETHOXAM 1994-98 data 

Residue file: C:\Documents and Settings\dmcneill\My Documents\Thiamethoxam_3\060109 

2010 T+FHE+Water.R98 

 Adjust. #2 NOT used 

Analysis Date 09-28-2010 Residue file dated: 09-28-2010/14:20:28/8 

Reference dose (RfD) = 0.012 mg/kg bw/day 

Comment:Acute and Chronic RfDs = aPAD and cPAD 

-------------------------------------------------------------------------------- 

Food Crop Residue Adj.Factors Comment 

EPA Code Grp Food Name (ppm) 

 #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ ------- 

95000010 O Acerola 0.010000 1.000 1.000 FHE 

18000020 18 Alfalfa, seed 0.010000 1.000 1.000 FHE 

14000030 14 Almond 0.010000 1.000 1.000 D34927 

 Full comment: D349272 

14000031 14 Almond-babyfood 0.010000 1.000 1.000 

14000040 14 Almond, oil 0.010000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.010000 1.000 1.000 

04010050 4A Amaranth, leafy 4.000000 1.000 1.000 

95000060 O Amaranth, grain 0.010000 1.000 1.000 FHE 

11000070 11 Apple, fruit with peel 0.060000 1.000 1.000 D28170 

 Full comment: D281702 & D265079 

11000080 11 Apple, peeled fruit 0.060000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 0.060000 1.000 1.000 

11000090 11 Apple, dried 0.060000 8.000 1.000 

11000091 11 Apple, dried-babyfood 0.060000 8.000 1.000 

11000100 11 Apple, juice 0.060000 0.750 1.000 

11000101 11 Apple, juice-babyfood 0.060000 0.750 1.000 

11000110 11 Apple, sauce 0.060000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 0.060000 1.000 1.000 

12000120 12 Apricot 0.210000 1.000 1.000 W. Cut 

 Full comment: W. Cuthchin 12/10/03 DERs 

12000121 12 Apricot-babyfood 0.210000 1.000 1.000 

12000130 12 Apricot, dried 0.210000 6.000 1.000 

12000140 12 Apricot, juice 0.210000 1.000 1.000 

12000141 12 Apricot, juice-babyfood 0.210000 1.000 1.000 

01030150 1CD Arrowroot, flour 0.010000 1.000 1.000 FHE 

01030151 1CD Arrowroot, flour-babyfood 0.010000 1.000 1.000 FHE 

95000160 O Artichoke, globe 0.190000 1.000 1.000 D28170 

 Full comment: D281702/D325447 

01030170 1CD Artichoke, Jerusalem 0.010000 1.000 1.000 FHE 

04010180 4A Arugula 4.000000 1.000 1.000 

95000190 O Asparagus 0.010000 1.000 1.000 FHE 

95000200 O Avocado 0.110000 1.000 1.000 D35744 

 Full comment: D357449/D357450 

09020210 9B Balsam pear 0.200000 1.000 1.000 

95000220 O Bamboo, shoots 0.010000 1.000 1.000 FHE 

95000230 O Banana 0.010000 1.000 1.000 FHE 

95000231 O Banana-babyfood 0.010000 1.000 1.000 FHE 

95000240 O Banana, dried 0.010000 1.000 1.000 FHE 

95000241 O Banana, dried-babyfood 0.010000 1.000 1.000 FHE 

15000250 15 Barley, pearled barley 0.086000 0.300 1.000 D28170 

 Full comment: D281702/D325447 

15000251 15 Barley, pearled barley-babyfood 0.086000 0.300 1.000 

15000260 15 Barley, flour 0.086000 0.100 1.000 

15000261 15 Barley, flour-babyfood 0.086000 0.100 1.000 

15000270 15 Barley, bran 0.086000 0.300 1.000 

19010280 19A Basil, fresh leaves 0.010000 1.000 1.000 FHE 

19010281 19A Basil, fresh leaves-babyfood 0.010000 1.000 1.000 FHE 

19010290 19A Basil, dried leaves 0.010000 1.000 1.000 FHE 

19010291 19A Basil, dried leaves-babyfood 0.010000 1.000 1.000 FHE 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 24 of 33 

06030300 6C Bean, black, seed 0.010000 1.000 1.000 S,. Ta 

 Full comment: S,. Tayayin, 26 Nov 2002 

06020310 6B Bean, broad, succulent 0.010000 1.000 1.000 

06030320 6C Bean, broad, seed 0.010000 1.000 1.000 

06020330 6B Bean, cowpea, succulent 0.010000 1.000 1.000 

06030340 6C Bean, cowpea, seed 0.010000 1.000 1.000 

06030350 6C Bean, great northern, seed 0.010000 1.000 1.000 

06030360 6C Bean, kidney, seed 0.010000 1.000 1.000 

06020370 6B Bean, lima, succulent 0.010000 1.000 1.000 

06030380 6C Bean, lima, seed 0.010000 1.000 1.000 

06030390 6C Bean, mung, seed 0.010000 1.000 1.000 

06030400 6C Bean, navy, seed 0.010000 1.000 1.000 

06030410 6C Bean, pink, seed 0.010000 1.000 1.000 

06030420 6C Bean, pinto, seed 0.010000 1.000 1.000 

06010430 6A Bean, snap, succulent 0.010000 1.000 1.000 

06010431 6A Bean, snap, succulent-babyfood 0.010000 1.000 1.000 

21000440 M Beef, meat 0.020000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.020000 1.000 1.000 

21000450 M Beef, meat, dried 0.020000 1.920 1.000 

21000460 M Beef, meat byproducts 0.040000 1.000 1.000 Rec. T 

 Full comment: Rec. Tol. 

21000461 M Beef, meat byproducts-babyfood 0.040000 1.000 1.000 

21000470 M Beef, fat 0.010000 1.000 1.000 FHE 

21000471 M Beef,fat-babyfood 0.010000 1.000 1.000 FHE 

21000480 M Beef, kidney 0.040000 1.000 1.000 

21000490 M Beef, liver 0.040000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.040000 1.000 1.000 

01010500 1AB Beet, garden, roots 0.050000 1.000 1.000 

01010501 1AB Beet, garden, roots-babyfood 0.050000 1.000 1.000 

02000510 2 Beet, garden, tops 0.010000 1.000 1.000 FHE 

01010520 1A Beet, sugar 0.050000 1.000 1.000 

01010521 1A Beet, sugar-babyfood 0.050000 1.000 1.000 

01010530 1A Beet, sugar, molasses 0.050000 1.000 1.000 

01010531 1A Beet, sugar, molasses-babyfood 0.050000 1.000 1.000 

95000540 O Belgium endive 0.010000 1.000 1.000 FHE 

13010550 13A Blackberry 0.120000 1.000 1.000 D28170 

 Full comment: D281702 

13010560 13A Blackberry, juice 0.120000 1.000 1.000 

13010561 13A Blackberry, juice-babyfood 0.120000 1.000 1.000 

13020570 13B Blueberry 0.300000 1.000 1.000 

13020571 13B Blueberry-babyfood 0.300000 1.000 1.000 

13010580 13A Boysenberry 0.120000 1.000 1.000 

14000590 14 Brazil nut 0.010000 1.000 1.000 

95000600 O Breadfruit 0.010000 1.000 1.000 FHE 

05010610 5A Broccoli 0.980000 1.000 1.000 D28170 

 Full comment: D281702 

05010611 5A Broccoli-babyfood 0.980000 1.000 1.000 

05010620 5A Broccoli, Chinese 0.980000 1.000 1.000 

05020630 5B Broccoli raab 0.820000 1.000 1.000 

05010640 5A Brussels sprouts 0.980000 1.000 1.000 

15000650 15 Buckwheat 0.020000 1.000 1.000 

15000660 15 Buckwheat, flour 0.020000 1.000 1.000 

01010670 1AB Burdock 0.050000 1.000 1.000 

14000680 14 Butternut 0.010000 1.000 1.000 

05010690 5A Cabbage 0.980000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 0.820000 1.000 1.000 D28170 

 Full comment: D281702 

05010710 5A Cabbage, Chinese, napa 0.980000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 0.980000 1.000 1.000 

95000730 O Cactus 0.010000 1.000 1.000 FHE 

95000740 O Canistel 0.400000 1.000 1.000 

09010750 9A Cantaloupe 0.200000 1.000 1.000 

04020760 4B Cardoon 4.000000 1.000 1.000 

95000770 O Carob 0.010000 1.000 1.000 FHE 

01010780 1AB Carrot 0.050000 1.000 1.000 

01010781 1AB Carrot-babyfood 0.050000 1.000 1.000 

01010790 1AB Carrot, juice 0.050000 1.000 1.000 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 25 of 33 

09010800 9A Casaba 0.200000 1.000 1.000 

14000810 14 Cashew 0.010000 1.000 1.000 

01030820 1CD Cassava 0.010000 1.000 1.000 FHE 

01030821 1CD Cassava-babyfood 0.010000 1.000 1.000 FHE 

05010830 5A Cauliflower 0.980000 1.000 1.000 

01010840 1AB Celeriac 0.050000 1.000 1.000 

04020850 4B Celery 4.000000 1.000 1.000 

04020851 4B Celery-babyfood 4.000000 1.000 1.000 

04020860 4B Celery, juice 4.000000 1.000 1.000 

04020870 4B Celtuce 4.000000 1.000 1.000 

09020880 9B Chayote, fruit 0.200000 1.000 1.000 

95000890 O Cherimoya 0.110000 1.000 1.000 

12000900 12 Cherry 0.210000 1.000 1.000 

12000901 12 Cherry-babyfood 0.210000 1.000 1.000 

12000910 12 Cherry, juice 0.210000 1.500 1.000 

12000911 12 Cherry, juice-babyfood 0.210000 1.500 1.000 

14000920 14 Chestnut 0.010000 1.000 1.000 

40000930 P Chicken, meat 0.010000 1.000 1.000 FHE 

40000931 P Chicken, meat-babyfood 0.010000 1.000 1.000 FHE 

40000940 P Chicken, liver 0.010000 1.000 1.000 FHE 

40000950 P Chicken, meat byproducts 0.010000 1.000 1.000 FHE 

40000951 P Chicken, meat byproducts-babyfoo 0.010000 1.000 1.000 FHE 

40000960 P Chicken, fat 0.010000 1.000 1.000 FHE 

40000961 P Chicken, fat-babyfood 0.010000 1.000 1.000 FHE 

40000970 P Chicken, skin 0.010000 1.000 1.000 FHE 

40000971 P Chicken, skin-babyfood 0.010000 1.000 1.000 FHE 

06030980 6C Chickpea, seed 0.010000 1.000 1.000 

06030981 6C Chickpea, seed-babyfood 0.010000 1.000 1.000 

06030990 6C Chickpea, flour 0.010000 1.000 1.000 

01011000 1AB Chicory, roots 0.050000 1.000 1.000 

02001010 2 Chicory, tops 0.010000 1.000 1.000 FHE 

09021020 9B Chinese waxgourd 0.200000 1.000 1.000 

19011030 19A Chive 0.010000 1.000 1.000 FHE 

04011040 4A Chrysanthemum, garland 4.000000 1.000 1.000 

19021050 19B Cinnamon 0.010000 1.000 1.000 FHE 

19021051 19B Cinnamon-babyfood 0.010000 1.000 1.000 FHE 

10001060 10 Citrus citron 0.100000 1.000 1.000 

10001070 10 Citrus hybrids 0.100000 1.000 1.000 

10001080 10 Citrus, oil 0.100000 0.600 1.000 

95001090 O Cocoa bean, chocolate 0.010000 1.000 1.000 FHE 

95001100 O Cocoa bean, powder 0.010000 1.000 1.000 FHE 

95001110 O Coconut, meat 0.010000 1.000 1.000 FHE 

95001111 O Coconut- meat-babyfood 0.010000 1.000 1.000 FHE 

95001120 O Coconut, dried 0.010000 1.000 1.000 FHE 

95001130 O Coconut, milk 0.010000 1.000 1.000 FHE 

95001140 O Coconut, oil 0.010000 1.000 1.000 FHE 

95001141 O Coconut, oil-babyfood 0.010000 1.000 1.000 FHE 

95001150 O Coffee, roasted bean 0.050000 1.000 1.000 

95001160 O Coffee, instant 0.050000 1.000 1.000 

05021170 5B Collards 0.820000 1.000 1.000 

19011180 19A Coriander, leaves 0.010000 1.000 1.000 FHE 

19011181 19A Coriander, leaves-babyfood 0.010000 1.000 1.000 FHE 

19021190 19B Coriander, seed 0.010000 1.000 1.000 FHE 

19021191 19B Coriander, seed-babyfood 0.010000 1.000 1.000 FHE 

15001200 15 Corn, field, flour 0.020000 1.000 1.000 

15001201 15 Corn, field, flour-babyfood 0.020000 1.000 1.000 

15001210 15 Corn, field, meal 0.020000 1.000 1.000 

15001211 15 Corn, field, meal-babyfood 0.020000 1.000 1.000 

15001220 15 Corn, field, bran 0.020000 1.000 1.000 

15001230 15 Corn, field, starch 0.020000 1.000 1.000 

15001231 15 Corn, field, starch-babyfood 0.020000 1.000 1.000 

15001240 15 Corn, field, syrup 0.020000 1.500 1.000 

15001241 15 Corn, field, syrup-babyfood 0.020000 1.500 1.000 

15001250 15 Corn, field, oil 0.020000 1.000 1.000 

15001251 15 Corn, field, oil-babyfood 0.020000 1.000 1.000 

15001260 15 Corn, pop 0.020000 1.000 1.000 

15001270 15 Corn, sweet 0.020000 1.000 1.000 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 26 of 33 

15001271 15 Corn, sweet-babyfood 0.020000 1.000 1.000 

95001280 O Cottonseed, oil 0.100000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.100000 1.000 1.000 

11001290 11 Crabapple 0.060000 1.000 1.000 

95001300 O Cranberry 0.020000 1.000 1.000 

95001301 O Cranberry-babyfood 0.020000 1.000 1.000 

95001310 O Cranberry, dried 0.020000 1.000 1.000 

95001320 O Cranberry, juice 0.020000 1.100 1.000 

95001321 O Cranberry, juice-babyfood 0.020000 1.100 1.000 

04011330 4A Cress, garden 4.000000 1.000 1.000 

04011340 4A Cress, upland 4.000000 1.000 1.000 

09021350 9B Cucumber 0.200000 1.000 1.000 

13021360 13B Currant 0.200000 1.000 1.000 

13021370 13B Currant, dried 0.200000 1.000 1.000 

04011380 4A Dandelion, leaves 4.000000 1.000 1.000 

01031390 1CD Dasheen, corm 0.010000 1.000 1.000 FHE 

02001400 2 Dasheen, leaves 0.010000 1.000 1.000 FHE 

95001410 O Date 0.010000 1.000 1.000 FHE 

13011420 13A Dewberry 0.120000 1.000 1.000 

19021430 19B Dill, seed 0.010000 1.000 1.000 FHE 

19011440 19A Dillweed 0.010000 1.000 1.000 FHE 

70001450 P Egg, whole 0.010000 1.000 1.000 FHE 

70001451 P Egg, whole-babyfood 0.010000 1.000 1.000 FHE 

70001460 P Egg, white 0.010000 1.000 1.000 FHE 

70001461 P Egg, white (solids)-babyfood 0.010000 1.000 1.000 FHE 

70001470 P Egg, yolk 0.010000 1.000 1.000 FHE 

70001471 P Egg, yolk-babyfood 0.010000 1.000 1.000 FHE 

08001480 8 Eggplant 0.080000 1.000 1.000 D28170 

 Full comment: D281702, tomato 

13021490 13B Elderberry 0.200000 1.000 1.000 

04011500 4A Endive 4.000000 1.000 1.000 

95001510 O Feijoa 0.010000 1.000 1.000 FHE 

04021520 4B Fennel, Florence 4.000000 1.000 1.000 

95001530 O Fig 0.010000 1.000 1.000 FHE 

95001540 O Fig, dried 0.010000 1.000 1.000 FHE 

14001550 14 Filbert 0.010000 1.000 1.000 

14001560 14 Filbert, oil 0.010000 1.000 1.000 

80001570 F Fish-freshwater finfish 0.010000 1.000 1.000 FHE 

80001580 F Fish-freshwater finfish, farm ra 0.010000 1.000 1.000 FHE 

80001590 F Fish-saltwater finfish, tuna 0.010000 1.000 1.000 FHE 

80001600 F Fish-saltwater finfish, other 0.010000 1.000 1.000 FHE 

80001610 F Fish-shellfish, crustacean 0.010000 1.000 1.000 FHE 

80001620 F Fish-shellfish, mollusc 0.010000 1.000 1.000 FHE 

20001630 20 Flaxseed, oil 0.020000 1.000 1.000 Tol. 

03001640 3 Garlic 0.010000 1.000 1.000 FHE 

03001650 3 Garlic, dried 0.010000 1.000 1.000 FHE 

03001651 3 Garlic, dried-babyfood 0.010000 1.000 1.000 FHE 

01031660 1CD Ginger 0.010000 1.000 1.000 FHE 

01031661 1CD Ginger-babyfood 0.010000 1.000 1.000 FHE 

01031670 1CD Ginger, dried 0.010000 1.000 1.000 FHE 

01011680 1AB Ginseng, dried 0.050000 1.000 1.000 

23001690 M Goat, meat 0.020000 1.000 1.000 

23001700 M Goat, meat byproducts 0.040000 1.000 1.000 Rec. T 

 Full comment: Rec. Tol. 

23001710 M Goat, fat 0.005000 1.000 1.000 FHE 

23001720 M Goat, kidney 0.040000 1.000 1.000 

23001730 M Goat, liver 0.040000 1.000 1.000 

13021740 13B Gooseberry 0.200000 1.000 1.000 

95001750 O Grape 0.060000 1.000 1.000 D28170 

 Full comment: D281702 

95001760 O Grape, juice 0.060000 1.100 1.000 

95001761 O Grape, juice-babyfood 0.060000 1.100 1.000 

95001770 O Grape, leaves 0.200000 1.000 1.000 

95001780 O Grape, raisin 0.060000 2.300 1.000 D28170 

 Full comment: D281702 

95001790 O Grape, wine and sherry 0.060000 1.000 1.000 

10001800 10 Grapefruit 0.070000 1.000 1.000 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 27 of 33 

10001810 10 Grapefruit, juice 0.070000 0.600 1.000 

06031820 6C Guar, seed 0.010000 1.000 1.000 

06031821 6C Guar, seed-babyfood 0.010000 1.000 1.000 

95001830 O Guava 0.010000 1.000 1.000 FHE 

95001831 O Guava-babyfood 0.010000 1.000 1.000 FHE 

19011840 19A Herbs, other 0.010000 1.000 1.000 FHE 

19011841 19A Herbs, other-babyfood 0.010000 1.000 1.000 FHE 

14001850 14 Hickory nut 0.010000 1.000 1.000 

95001860 O Honey 0.010000 1.000 1.000 FHE 

95001861 O Honey-babyfood 0.010000 1.000 1.000 FHE 

09011870 9A Honeydew melon 0.200000 1.000 1.000 

95001880 O Hop 0.100000 1.000 1.000 

24001890 M Horse, meat 0.020000 1.000 1.000 

01011900 1AB Horseradish 0.050000 1.000 1.000 

13021910 13B Huckleberry 0.200000 1.000 1.000 

95001920 O Jaboticaba 0.010000 1.000 1.000 FHE 

95001930 O Jackfruit 0.010000 1.000 1.000 FHE 

05021940 5B Kale 0.820000 1.000 1.000 

95001950 O Kiwifruit 0.010000 1.000 1.000 FHE 

05011960 5A Kohlrabi 0.980000 1.000 1.000 

10001970 10 Kumquat 0.400000 1.000 1.000 

03001980 3 Leek 0.010000 1.000 1.000 FHE 

10001990 10 Lemon 0.090000 1.000 1.000 

10002000 10 Lemon, juice 0.090000 0.600 1.000 

10002001 10 Lemon, juice-babyfood 0.090000 0.600 1.000 

10002010 10 Lemon, peel 0.090000 1.000 1.000 

19012020 19A Lemongrass 0.010000 1.000 1.000 FHE 

06032030 6C Lentil, seed 0.010000 1.000 1.000 

04012040 4A Lettuce, head 4.000000 1.000 1.000 

04012050 4A Lettuce, leaf 4.000000 1.000 1.000 

10002060 10 Lime 0.100000 1.000 1.000 

10002070 10 Lime, juice 0.100000 0.600 1.000 

10002071 10 Lime, juice-babyfood 0.100000 0.600 1.000 

13012080 13A Loganberry 0.120000 1.000 1.000 

95002090 O Longan 0.010000 1.000 1.000 FHE 

11002100 11 Loquat 0.060000 1.000 1.000 

95002110 O Lychee 0.010000 1.000 1.000 FHE 

95002120 O Lychee, dried 0.010000 1.000 1.000 FHE 

14002130 14 Macadamia nut 0.010000 1.000 1.000 

95002140 O Mamey apple 0.010000 1.000 1.000 FHE 

95002150 O Mango 0.110000 1.000 1.000 D35744 

 Full comment: D357449, avacado 

95002151 O Mango-babyfood 0.110000 1.000 1.000 

95002160 O Mango, dried 0.110000 1.000 1.000 

95002170 O Mango, juice 0.110000 1.000 1.000 

95002171 O Mango, juice-babyfood 0.110000 1.000 1.000 

95002180 O Maple, sugar 0.010000 1.000 1.000 FHE 

95002190 O Maple syrup 0.010000 1.000 1.000 FHE 

19012200 19A Marjoram 0.010000 1.000 1.000 FHE 

19012201 19A Marjoram-babyfood 0.010000 1.000 1.000 FHE 

28002210 M Meat, game 0.020000 1.000 1.000 

27002220 D Milk, fat 0.020000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.020000 1.000 1.000 

27012230 D Milk, nonfat solids 0.020000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.020000 1.000 1.000 

27022240 D Milk, water 0.020000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.020000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.020000 1.000 1.000 

15002260 15 Millet, grain 0.020000 1.000 1.000 

95002270 O Mulberry 0.010000 1.000 1.000 FHE 

95002280 O Mushroom 0.010000 1.000 1.000 FHE 

05022290 5B Mustard greens 0.820000 1.000 1.000 

12002300 12 Nectarine 0.210000 1.000 1.000 

15002310 15 Oat, bran 0.020000 1.000 1.000 

15002320 15 Oat, flour 0.020000 1.000 1.000 

15002321 15 Oat, flour-babyfood 0.020000 1.000 1.000 

15002330 15 Oat, groats/rolled oats 0.020000 1.000 1.000 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 28 of 33 

15002331 15 Oat, groats/rolled oats-babyfood 0.020000 1.000 1.000 

08002340 8 Okra 0.080000 1.000 1.000 

95002350 O Olive 0.010000 1.000 1.000 FHE 

95002360 O Olive, oil 0.010000 1.000 1.000 FHE 

03002370 3 Onion, dry bulb 0.030000 1.000 1.000 

03002371 3 Onion, dry bulb-babyfood 0.030000 1.000 1.000 

03002380 3 Onion, dry bulb, dried 0.030000 9.000 1.000 

03002381 3 Onion, dry bulb, dried-babyfood 0.030000 9.000 1.000 

03002390 3 Onion, green 0.010000 1.000 1.000 FHE 

10002400 10 Orange 0.100000 1.000 1.000 

10002410 10 Orange, juice 0.100000 0.600 1.000 

10002411 10 Orange, juice-babyfood 0.100000 0.600 1.000 

10002420 10 Orange, peel 0.100000 1.000 1.000 

95002430 O Palm heart, leaves 0.010000 1.000 1.000 FHE 

95002440 O Palm, oil 0.010000 1.000 1.000 FHE 

95002441 O Palm, oil-babyfood 0.010000 1.000 1.000 FHE 

95002450 O Papaya 0.110000 1.000 1.000 

95002451 O Papaya-babyfood 0.110000 1.000 1.000 

95002460 O Papaya, dried 0.110000 1.800 1.000 

95002470 O Papaya, juice 0.110000 1.500 1.000 

04012480 4A Parsley, leaves 4.000000 1.000 1.000 

19012490 19A Parsley, dried leaves 0.010000 1.000 1.000 FHE 

19012491 19A Parsley, dried leaves-babyfood 0.010000 1.000 1.000 FHE 

01012500 1AB Parsley, turnip rooted 0.050000 1.000 1.000 

01012510 1AB Parsnip 0.050000 1.000 1.000 

01012511 1AB Parsnip-babyfood 0.050000 1.000 1.000 

95002520 O Passionfruit 0.010000 1.000 1.000 FHE 

95002521 O Passionfruit-babyfood 0.010000 1.000 1.000 FHE 

95002530 O Passionfruit, juice 0.010000 1.000 1.000 FHE 

95002531 O Passionfruit, juice-babyfood 0.010000 1.000 1.000 FHE 

95002540 O Pawpaw 0.010000 1.000 1.000 FHE 

06022550 6B Pea, succulent 0.010000 1.000 1.000 

06022551 6B Pea, succulent-babyfood 0.010000 1.000 1.000 

06032560 6C Pea, dry 0.010000 1.000 1.000 

06032561 6C Pea, dry-babyfood 0.010000 1.000 1.000 

06012570 6A Pea, edible podded, succulent 0.010000 1.000 1.000 

06032580 6C Pea, pigeon, seed 0.010000 1.000 1.000 

06022590 6B Pea, pigeon, succulent 0.010000 1.000 1.000 

12002600 12 Peach 0.070000 1.000 1.000 

12002601 12 Peach-babyfood 0.070000 1.000 1.000 

12002610 12 Peach, dried 0.070000 7.000 1.000 

12002611 12 Peach, dried-babyfood 0.070000 7.000 1.000 

12002620 12 Peach, juice 0.070000 1.000 1.000 

12002621 12 Peach, juice-babyfood 0.070000 1.000 1.000 

95002630 O Peanut 0.050000 1.000 1.000 New To 

 Full comment: New Tol. 

95002640 O Peanut, butter 0.050000 1.000 1.000 

95002650 O Peanut, oil 0.050000 0.310 1.000 

11002660 11 Pear 0.060000 1.000 1.000 

11002661 11 Pear-babyfood 0.060000 1.000 1.000 

11002670 11 Pear, dried 0.060000 6.250 1.000 

11002680 11 Pear, juice 0.060000 0.750 1.000 

11002681 11 Pear, juice-babyfood 0.060000 0.750 1.000 

14002690 14 Pecan 0.010000 1.000 1.000 

08002700 8 Pepper, bell 0.080000 1.000 1.000 D28170 

 Full comment: D281702, pepper 

08002701 8 Pepper, bell-babyfood 0.080000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.080000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.080000 1.000 1.000 

08002720 8 Pepper, nonbell 0.080000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.080000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.080000 1.000 1.000 

19022740 19B Pepper, black and white 0.010000 1.000 1.000 FHE 

19022741 19B Pepper, black and white-babyfood 0.010000 1.000 1.000 FHE 

95002750 O Peppermint 1.500000 1.000 1.000 

95002760 O Peppermint, oil 1.500000 0.050 1.000 

95002770 O Persimmon 0.010000 1.000 1.000 FHE 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 29 of 33 

95002780 O Pine nut 0.010000 1.000 1.000 FHE 

95002790 O Pineapple 0.010000 1.000 1.000 FHE 

95002791 O Pineapple-babyfood 0.010000 1.000 1.000 FHE 

95002800 O Pineapple, dried 0.010000 1.000 1.000 FHE 

95002810 O Pineapple, juice 0.010000 1.000 1.000 FHE 

95002811 O Pineapple, juice-babyfood 0.010000 1.000 1.000 FHE 

14002820 14 Pistachio 0.010000 1.000 1.000 

95002830 O Plantain 0.010000 1.000 1.000 FHE 

95002840 O Plantain, dried 0.010000 1.000 1.000 FHE 

12002850 12 Plum 0.071000 1.000 1.000 

12002851 12 Plum-babyfood 0.071000 1.000 1.000 

12002860 12 Plum, prune, fresh 0.071000 1.000 1.000 

12002861 12 Plum, prune, fresh-babyfood 0.071000 1.000 1.000 

12002870 12 Plum, prune, dried 0.071000 5.000 1.000 

12002871 12 Plum, prune, dried-babyfood 0.071000 5.000 1.000 

12002880 12 Plum, prune, juice 0.071000 1.400 1.000 

12002881 12 Plum, prune, juice-babyfood 0.071000 1.400 1.000 

95002890 O Pomegranate 0.010000 1.000 1.000 FHE 

25002900 M Pork, meat 0.020000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.020000 1.000 1.000 

25002910 M Pork, skin 0.010000 1.000 1.000 FHE 

25002920 M Pork, meat byproducts 0.020000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.020000 1.000 1.000 

25002930 M Pork, fat 0.010000 1.000 1.000 FHE 

25002931 M Pork, fat-babyfood 0.010000 1.000 1.000 FHE 

25002940 M Pork, kidney 0.020000 1.000 1.000 

25002950 M Pork, liver 0.020000 1.000 1.000 

01032960 1C Potato, chips 0.250000 1.200 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.250000 1.700 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.250000 1.700 1.000 

01032980 1C Potato, flour 0.250000 1.700 1.000 

01032981 1C Potato, flour-babyfood 0.250000 1.700 1.000 

01032990 1C Potato, tuber, w/peel 0.250000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.250000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.250000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.250000 1.000 1.000 

60003010 P Poultry, other, meat 0.010000 1.000 1.000 FHE 

60003020 P Poultry, other, liver 0.010000 1.000 1.000 FHE 

60003030 P Poultry, other, meat byproducts 0.010000 1.000 1.000 FHE 

60003040 P Poultry, other, fat 0.010000 1.000 1.000 FHE 

60003050 P Poultry, other, skin 0.010000 1.000 1.000 FHE 

95003060 O Psyllium, seed 0.010000 1.000 1.000 FHE 

10003070 10 Pummelo 0.100000 1.000 1.000 

09023080 9B Pumpkin 0.200000 1.000 1.000 

09023090 9B Pumpkin, seed 0.200000 1.000 1.000 

11003100 11 Quince 0.060000 1.000 1.000 

95003110 O Quinoa, grain 0.010000 1.000 1.000 FHE 

29003120 M Rabbit, meat 0.020000 1.000 1.000 

04013130 4A Radicchio 4.000000 1.000 1.000 

01013140 1AB Radish, roots 0.050000 1.000 1.000 

02003150 2 Radish, tops 0.010000 1.000 1.000 FHE 

01013160 1AB Radish, Oriental, roots 0.050000 1.000 1.000 

02003170 2 Radish, Oriental, tops 0.010000 1.000 1.000 FHE 

05023180 5B Rape greens 0.820000 1.000 1.000 

20003190 20 Rapeseed, oil 0.020000 1.000 1.000 

20003191 20 Rapeseed, oil-babyfood 0.020000 1.000 1.000 

13013200 13A Raspberry 0.120000 1.000 1.000 

13013201 13A Raspberry-babyfood 0.120000 1.000 1.000 

13013210 13A Raspberry, juice 0.120000 1.000 1.000 

13013211 13A Raspberry, juice-babyfood 0.120000 1.000 1.000 

04023220 4B Rhubarb 4.000000 1.000 1.000 

15003230 15 Rice, white 0.010000 1.000 1.000 

15003231 15 Rice, white-babyfood 0.010000 1.000 1.000 

15003240 15 Rice, brown 0.010000 1.000 1.000 

15003241 15 Rice, brown-babyfood 0.010000 1.000 1.000 

15003250 15 Rice, flour 0.010000 1.000 1.000 

15003251 15 Rice, flour-babyfood 0.010000 1.000 1.000 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 30 of 33 

15003260 15 Rice, bran 0.010000 0.900 1.000 

15003261 15 Rice, bran-babyfood 0.010000 0.900 1.000 

01013270 1AB Rutabaga 0.050000 1.000 1.000 

15003280 15 Rye, grain 0.020000 1.000 1.000 

15003290 15 Rye, flour 0.020000 1.000 1.000 

20003300 20 Safflower, oil 0.020000 1.000 1.000 

20003301 20 Safflower, oil-babyfood 0.020000 1.000 1.000 

01013310 1AB Salsify, roots 0.050000 1.000 1.000 

02003320 2 Salsify, tops 0.010000 1.000 1.000 FHE 

95003330 O Sapote, Mamey 0.400000 1.000 1.000 

19013340 19A Savory 0.010000 1.000 1.000 FHE 

95003350 O Seaweed 0.010000 1.000 1.000 FHE 

95003351 O Seaweed-babyfood 0.010000 1.000 1.000 FHE 

95003360 O Sesame, seed 0.010000 1.000 1.000 FHE 

95003361 O Sesame, seed-babyfood 0.010000 1.000 1.000 FHE 

95003370 O Sesame, oil 0.010000 1.000 1.000 FHE 

95003371 O Sesame, oil-babyfood 0.010000 1.000 1.000 FHE 

03003380 3 Shallot 0.010000 1.000 1.000 FHE 

26003390 M Sheep, meat 0.020000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.020000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.040000 1.000 1.000 

26003410 M Sheep, fat 0.010000 1.000 1.000 FHE 

26003411 M Sheep, fat-babyfood 0.010000 1.000 1.000 FHE 

26003420 M Sheep, kidney 0.040000 1.000 1.000 

26003430 M Sheep, liver 0.040000 1.000 1.000 

15003440 15 Sorghum, grain 0.020000 1.000 1.000 

15003450 15 Sorghum, syrup 0.020000 1.000 1.000 

95003460 O Soursop 0.010000 1.000 1.000 FHE 

06003470 6 Soybean, seed 0.010000 1.000 1.000 D28170 

 Full comment: D281702 

06003480 6 Soybean, flour 0.010000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.010000 1.000 1.000 

06003490 6 Soybean, soy milk 0.010000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.010000 1.000 1.000 

06003500 6 Soybean, oil 0.010000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.010000 1.000 1.000 

95003510 O Spanish lime 0.010000 1.000 1.000 FHE 

95003520 O Spearmint 1.500000 1.000 1.000 

95003530 O Spearmint, oil 1.500000 0.050 1.000 D28170 

 Full comment: D281702 

19023540 19B Spices, other 0.010000 1.000 1.000 FHE 

19023541 19B Spices, other-babyfood 0.010000 1.000 1.000 FHE 

04013550 4A Spinach 4.000000 1.000 1.000 

04013551 4A Spinach-babyfood 4.000000 1.000 1.000 

09023560 9B Squash, summer 0.200000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.200000 1.000 1.000 

09023570 9B Squash, winter 0.200000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.200000 1.000 1.000 

95003580 O Starfruit 0.010000 1.000 1.000 FHE 

95003590 O Strawberry 0.300000 1.000 1.000 

95003591 O Strawberry-babyfood 0.300000 1.000 1.000 

95003600 O Strawberry, juice 0.300000 1.000 1.000 

95003601 O Strawberry, juice-babyfood 0.300000 1.000 1.000 

95003610 O Sugar apple 0.010000 1.000 1.000 FHE 

95003620 O Sugarcane, sugar 0.010000 1.000 1.000 FHE 

95003621 O Sugarcane, sugar-babyfood 0.010000 1.000 1.000 FHE 

95003630 O Sugarcane, molasses 0.010000 1.000 1.000 FHE 

95003631 O Sugarcane, molasses-babyfood 0.010000 1.000 1.000 FHE 

20003640 20 Sunflower, seed 0.020000 1.000 1.000 

20003650 20 Sunflower, oil 0.020000 1.000 1.000 

20003651 20 Sunflower, oil-babyfood 0.020000 1.000 1.000 

01033660 1CD Sweet potato 0.020000 1.000 1.000 

01033661 1CD Sweet potato-babyfood 0.020000 1.000 1.000 

04023670 4B Swiss chard 4.000000 1.000 1.000 

95003680 O Tamarind 0.010000 1.000 1.000 FHE 

10003690 10 Tangerine 0.100000 1.000 1.000 

10003700 10 Tangerine, juice 0.100000 0.600 1.000 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 31 of 33 

01033710 1CD Tanier, corm 0.020000 1.000 1.000 

95003720 O Tea, dried 0.010000 1.000 1.000 FHE 

95003730 O Tea, instant 0.010000 1.000 1.000 FHE 

08003740 8 Tomatillo 0.080000 1.000 1.000 

08003750 8 Tomato 0.080000 1.000 1.000 

08003751 8 Tomato-babyfood 0.080000 1.000 1.000 

08003760 8 Tomato, paste 0.080000 3.800 1.000 D26507 

 Full comment: D265079 

08003761 8 Tomato, paste-babyfood 0.080000 3.800 1.000 

08003770 8 Tomato, puree 0.080000 1.700 1.000 D26507 

 Full comment: D265079 

08003771 8 Tomato, puree-babyfood 0.080000 1.700 1.000 

08003780 8 Tomato, dried 0.080000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.080000 14.300 1.000 

08003790 8 Tomato, juice 0.080000 1.500 1.000 

95003800 O Tomato, Tree 0.010000 1.000 1.000 FHE 

15003810 15 Triticale, flour 0.020000 1.000 1.000 

15003811 15 Triticale, flour-babyfood 0.020000 1.000 1.000 

50003820 P Turkey, meat 0.010000 1.000 1.000 FHE 

50003821 P Turkey, meat-babyfood 0.010000 1.000 1.000 FHE 

50003830 P Turkey, liver 0.010000 1.000 1.000 FHE 

50003831 P Turkey, liver-babyfood 0.010000 1.000 1.000 FHE 

50003840 P Turkey, meat byproducts 0.010000 1.000 1.000 FHE 

50003841 P Turkey, meat byproducts-babyfood 0.010000 1.000 1.000 FHE 

50003850 P Turkey, fat 0.010000 1.000 1.000 FHE 

50003851 P Turkey, fat-babyfood 0.010000 1.000 1.000 FHE 

50003860 P Turkey, skin 0.010000 1.000 1.000 FHE 

50003861 P Turkey, skin-babyfood 0.010000 1.000 1.000 FHE 

01033870 1CD Turmeric 0.250000 1.000 1.000 

01013880 1AB Turnip, roots 0.050000 1.000 1.000 

05023890 5B Turnip, greens 0.820000 1.000 1.000 

95003900 O Vinegar 0.010000 1.000 1.000 FHE 

14003910 14 Walnut 0.010000 1.000 1.000 

86010000 O Water, direct, all sources 0.011310 1.000 1.000 

86020000 O Water, indirect, all sources 0.011310 1.000 1.000 

09013990 9A Watermelon 0.200000 1.000 1.000 

09014000 9A Watermelon, juice 0.200000 1.000 1.000 

15004010 15 Wheat, grain 0.020000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.020000 1.000 1.000 

15004020 15 Wheat, flour 0.020000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.020000 1.000 1.000 

15004030 15 Wheat, germ 0.020000 1.000 1.000 

15004040 15 Wheat, bran 0.020000 1.000 1.000 

15004050 15 Wild rice 0.020000 1.000 1.000 

01034060 1CD Yam, true 0.250000 1.000 1.000 

01034070 1CD Yam bean 0.250000 1.000 1.000 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 32 of 33 

Attachment 3. Summary of the acute dietary exposure analysis 

for thiamethoxam.

U.S. Environmental Protection Agency Ver. 2.02 

DEEM-FCID ACUTE Analysis for THIAMETHOXAM (1994-98 data) 

Residue file: 060109 2010 Acute T+Water.R98 Adjustment factor #2 NOT used. 

Analysis Date: 09-28-2010/14:24:08 Residue file dated: 09-28-2010/14:19:26/8 

Daily totals for food and foodform consumption used. 

Run Comment: "Acute and Chronic RfDs = aPAD and cPAD" 

=============================================================================== 

Summary calculations (per capita): 

 95th Percentile 99th Percentile 99.9th Percentile 

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- -------- 

U.S. Population: 

 0.018094 5.17 0.029790 8.51 0.058415 16.69 

All infants: 

 0.033165 9.48 0.053499 15.29 0.087409 24.97 

Children 1-2 yrs: 

 0.032947 9.41 0.056186 16.05 0.108420 30.98 

Children 3-5 yrs: 

 0.026627 7.61 0.046231 13.21 0.079162 22.62 

Children 6-12 yrs: 

 0.018819 5.38 0.034746 9.93 0.071004 20.29 

Youth 13-19 yrs: 

 0.014311 4.09 0.022203 6.34 0.038760 11.07 

Adults 20-49 yrs: 

 0.016277 4.65 0.025243 7.21 0.042160 12.05 

Adults 50+ yrs: 

 0.016617 4.75 0.025593 7.31 0.040500 11.57 

Females 13-49 yrs: 

 0.016123 4.61 0.025604 7.32 0.046388 13.25 
Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368 

Page 33 of 33 

Attachment 4. Summary of the chronic dietary exposure analysis 

for thiamethoxam.

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for THIAMETHOXAM (1994-98 data) 

Residue file name: C:\Documents and Settings\dmcneill\My Documents\Thiamethoxam_3\060109 2010 

T+FHE+Water.R98 

 Adjustment factor #2 NOT used. 

Analysis Date 09-28-2010/14:21:15 Residue file dated: 09-28-2010/14:20:28/8 

Reference dose (RfD, Chronic) = .012 mg/kg bw/day 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- --------------- 

U.S. Population (total) 0.002825 23.5% 

U.S. Population (spring season) 0.002894 24.1% 

U.S. Population (summer season) 0.002814 23.5% 

U.S. Population (autumn season) 0.002786 23.2% 

U.S. Population (winter season) 0.002809 23.4% 

Northeast region 0.002932 24.4% 

Midwest region 0.002844 23.7% 

Southern region 0.002543 21.2% 

Western region 0.003155 26.3% 

Hispanics 0.002912 24.3% 

Non-hispanic whites 0.002826 23.5% 

Non-hispanic blacks 0.002448 20.4% 

Non-hisp/non-white/non-black 0.003674 30.6% 

All infants (< 1 year) 0.003052 25.4% 

Nursing infants 0.001338 11.2% 

Non-nursing infants 0.003703 30.9% 

Children 1-6 yrs 0.004617 38.5% 

Children 7-12 yrs 0.003133 26.1% 

Females 13-19 (not preg or nursing) 0.002248 18.7% 

Females 20+ (not preg or nursing) 0.002722 22.7% 

Females 13-50 yrs 0.002669 22.2% 

Females 13+ (preg/not nursing) 0.002473 20.6% 

Females 13+ (nursing) 0.003126 26.1% 

Males 13-19 yrs 0.002398 20.0% 

Males 20+ yrs 0.002493 20.8% 

Seniors 55+ 0.002624 21.9% 

Children 1-2 yrs 0.005150 42.9% 

Children 3-5 yrs 0.004520 37.7% 

Children 6-12 yrs 0.003241 27.0% 

Youth 13-19 yrs 0.002333 19.4% 

Adults 20-49 yrs 0.002591 21.6% 

Adults 50+ yrs 0.002648 22.1% 

Females 13-49 yrs 0.002617 21.8% 

-------------------------------------------------------------------------------