EX-10.6



 Exhibit 10.6 

SECOND AMENDMENT TO LEASE 
  

	I.	PARTIES AND DATE. 

 This Second Amendment to Lease (the “Amendment”) dated
March 7, 2006, is by and between THE IRVINE COMPANY (“Landlord”), and SPECTRUM PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”). 
  

	II.	RECITALS. 

 On January 16, 1997, Landlord and Tenant entered into a lease for space
in a building located at 157 Technology Drive, Irvine, California (“Premises”), which lease was amended by a First Amendment to Lease dated March 25, 2004 (as amended, the “Lease”). 

Landlord and Tenant each desire to modify the Lease to make such modifications as are set forth in “III. MODIFICATIONS” next below.

  

	III.	MODIFICATIONS. 

 A. Signage. The first 1st sentence of Section 5.2 of the Lease is hereby deleted and substituted therefor with the following: 

“Provided Tenant continues to lease the entire Building, Tenant shall have the non-exclusive right to one (1) exterior building top
sign on the Building for Tenant’s name and graphics in a location designated by Landlord, subject to Landlord’s right of prior approval that such exterior signage is in compliance with the Signage Criteria (defined below). Except as
provided in the foregoing, Tenant shall have no right to maintain signs in any location in, on or about the Premises, the Building or the Project and shall not place or erect any signs, displays or other advertising materials that are visible from
the exterior of the Building.” 
  

	IV.	GENERAL. 

 A. Effect of Amendments. The Lease shall remain in full force and
effect except to the extent that it is modified by this Amendment. 
 B. Entire Agreement. This Amendment embodies the entire
understanding between Landlord and Tenant with respect to the modifications set forth in “III. MODIFICATIONS” above and can be changed only by a writing signed by Landlord and Tenant. 

C. Counterparts. If this Amendment is executed in counterparts, each is hereby declared to be an original; all, however, shall
constitute but one and the same amendment. In any action or proceeding, any photographic, photostatic, or other copy of this Amendment may be introduced into evidence without foundation. 

D. Defined Terms. All words commencing with initial capital letters in this Amendment and defined in the Lease shall have the same
meaning in this Amendment as in the Lease, unless they are otherwise defined in this Amendment. 
 E. Corporate and Partnership
Authority. If Tenant is a corporation or partnership, or is comprised of either or both of them, each individual executing this Amendment for the corporation or partnership represents that he or she is duly authorized to execute and deliver this
Amendment on behalf of the corporation or partnership and that this Amendment is binding upon the corporation or partnership in accordance with its terms. 

F. Attorneys’ Fees. The provisions of the Lease respecting payment of attorneys’ fees shall also apply to this Amendment.


  
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	V.	EXECUTION. 

 Landlord and Tenant executed this Amendment on the date as set forth in
“I. PARTIES AND DATE.” above. 
  

									
	LANDLORD:	 		 	TENANT:
			
	THE IRVINE COMPANY	 		 	SPECTRUM PHARMACEUTICALS, INC.,
		 		 		 	a Delaware corporation
					
	By	 	 /s/ Steven M. Case
	 		 	By	 	 /s/ Rajesh C. Shrotriya, M.D.

		 	Steven M. Case, Senior Vice President	 		 	Name	 	Rajesh C. Shrotriya, M.D.
		 	Leasing, Office Properties	 		 	Title Chairman, CEO & President
					
	By	 	 /s/ Christopher J. Popma
	 		 	By	 	 /s/ Shyam Kumaria

		 	Christopher J. Popma, Vice President	 		 	Name	 	Shyam Kumaria
		 	Operations, Office Properties	 		 	Title	 	V.P., Finance


  
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