### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 1 of 33 UNITED STATES ENVIRONMEN TAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

Office of Chemical Safety

and Pollution Prevention



## MEMORANDUM

DATE: Nov 23, 2010

SUBJECT: Thiamethoxam

. Acute and Chronic Aggregat e Dietary (Food and Drinking Water) Exposure and Risk Assessments for the Section 3 Registration as a Seed Treatment for Alfalfa and Peanuts, and for Use in Food Handling Establishments.

PC Code: 060109 DP Barcode: D376368 Decision Number: D424517 Registration Numbers: 100- RGAL, 100-941, 1001306 Petition Numbers: 9F7657, 9F7707, 0F 7734 Regulatory Action: Section 3 Registration Assessment Type: Dietary Case Number: 7614

TXR Number: NA CAS Number: 153719-23-4 MRID Number: NA 40CFR §180.565



## REVIEWER: Dennis McNeilly, Chemist Risk Assessment Branch II (RAB2) Health Effects Division (HED), 7509P

THROUGH: Donna Davis, Chemist David Hrdy, Biologist Dietary Exposure Science Advisory Council (DESAC) Health Effects Division (HED), 7509P

TO: Kable Davis/Venus Eagle, Team 01

Insecticide/Rodenticide Branch Registration Division (RD), 7505P

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 2 of 33 Executive Summary

Acute and chronic aggregate di etary (food and drinking water) exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCIDTM), Ve rsion 2.03, which uses food consumption data from the US Department of Agriculture’s C ontinuing Surveys of Food Intakes by Individuals (CSFII), collected from 1994 to 1996, and 1998. These analyses were performed to support the Section 3 request for thiamethoxam use as a seed treatment for alfalfa an d peanuts, and for the

treatment of food hand ling establishments.

Tolerances for residues of thiamethoxam ar e listed in 40 CFR §180.565 and are expressed in

terms of the combined residues of the inse cticide thiamethoxam and its metabolite CGA-322704. Thiamethoxam’s major metabolite is CGA-322704, which is also the registered active ingredient

clothianidin. Clothianidin has a complete toxicological database and appears to have effects in

mammals that are different from those of thiamethoxa m. Prior to receipt of the complete toxicity database for clothianidin, the Agency assumed, ba sed on structural similari ty, that the toxicity profile for clothianidin was equivalent to th iamethoxam, and conducted risk assessments on the

combined thiamethoxam and clothianidin residu es. The Agency notes that the complete

database has demonstrated that clothianidin does not have the sa me toxicity profile and residues

of clothianidin need not be added to residues of thiame thoxam and compared to the thiamethoxam endpoints for risk assessment, in stead separate dietary exposure and risk

assessments should be conducted for thiamethoxa m and clothianidin. However, given the complexity of previous combined assessments, th e Agency is continuing to include residues of

clothianidin from thiamethoxam uses in the thia methoxam risk assessment recognizing that this

is an overestimate of risk. Since risks for th iamethoxam using combined residue values are not of concern, it is not necessary at this time to revisit previous dietary inputs and separate out residues of the parent compound only. A separate risk assessment which addresses risks from clothianidin residues resulting from the direct applicati on of clothianidin as well as risks from residues of clothianidin coming from thiamet hoxam uses is being conducted (Michael Doherty, D384145) concurrently to support the new uses that are the subject of this action.

The acute assessment is based on tolerance leve l residues of thiamethoxam/clothianidin (the

tolerance is for combined residue s). The chronic analysis is based on tolerance level/proposed tolerance levels and/or average field tria l (D376367, W. Drew, 2 Nov 2010) residues and assumes 100% crop treated for all commodities. For the chronic analysis, an anticipated residue of 0.01 ppm was used for residues in or on all commodities for which there are no existing or proposed thiamethoxam tolerances since the proposed new uses include food handling establishment use. The assumption of 100% CT in these analyses (acute a nd chronic) results in a

conservative assessment for thiamethoxam. The analyses included dir ect incorporation of

estimated thiamethoxam/clothianid in residues in drinking water. Clothianidin is not a major degradate of thiamethoxam in water; therefore th e water numbers reflect residues of the parent compound only. For water, the highest estimate from conservative models was used for both the

acute and the chronic di etary exposure analyses.

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 3 of 33 Based on these highly conservative assumptions, acute dietary (food and water) risk estimates at the 95th percentile of exposure are less than or equa l to 9.5% of the acute population-adjusted dose (aPAD) for all population subgroups. Chro nic dietary (food and wate r) risk estimates are less than or equal to 43% of the chronic population-adjusted dose (cPAD) for all population subgroups. Generally, HED is c oncerned when risk estimates exceed 100% of the PAD; therefore, all acute and chronic dietary risk estimates are below HED’s level of concern (LOC).

These analyses indicate that th ere are no dietary exposure consid erations that would preclude registration of thiamethoxam for the requested se ed treatment uses on alfalfa and peanuts, and the treatment of food handling establishments.

1. Introduction

Dietary risk assessment incorporat es both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expresse d as a percentage of a maximum acceptable dose (the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the populat ion adjusted dose (PAD). The PAD is equivalent to the point of departure (POD), such as the NOAEL or LOAEL, divided by the requisite uncertainty and/or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk

exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in

more detail are available on the EPA pesticides web site, Available Information on Assessing Exposure from Pesticides, A User’s Guide (21 June 2000), which can be accessed via the web

link http://www.epa.gov/fedrgstr/E PA-PEST/2000/July/Day-12/6061.pdf (or see SOP 99.6, dated 8/20/1999).

The most recent dietary risk assessment for thiamethoxam was conducted by D. McNeilly (D373595, 3 May 2010).

2. Residue Information

Tolerances have been established for both thiamethoxam (40CFR §180.565) and clothianidin (40CFR §180.586) on a variety of commodities. This assessment includes residue estimates associated with the requested Se ction 3 registration of thiamethoxam use as a seed treatment for alfalfa and peanuts, and for the thiamethoxam tr eatment of food handling establishments (see Table 2). The residue of concern for this di etary risk assessment is thiamethoxan and its metabolite, clothianidin.

As discussed above, thiamethoxam’s major metabolite is CGA-322704, which is also the registered active ingredient clothi anidin. Clothianidin has a complete toxicological database and appears to have effects in mamm als that are different from thos e of thiamethoxam. Prior to receipt of the complete toxicity database for clothianidin, the Agency assumed, based on structural similarity, that the t oxicity profile for clothianidin was equivalent to thiamethoxam,

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 4 of 33 and conducted risk assessments on the combined thiamethoxam and clothianidin residues. The Agency notes that the complete database has de monstrated that clothianidin does not have the same toxicity profile and residues of clothianidin need not be added to residues of thiamethoxam and compared to the thiamethoxam endpoints for risk assessment, instead separate dietary exposure and risk assessments should be c onducted for thiamethoxam and clothianidin. However, given the complexity of previous comb ined assessments, the Ag ency is continuing to

include residues of clothianidin from thiamethoxam uses in the thiamethoxam risk assessment recognizing that this is an overestimate of risk.

Table 1. HED-Recommended Tolerances for Thiamet hoxam’s Proposed Uses in /on Alfalfa, Peanuts and Food Handling Establishment Use.

Commodity Proposed Tolerance (ppm) Recommended Tolerance (ppm) Comments; Correct Commodity Definition

Tolerances Proposed under 180.565(a)

Alfalfa, forage 0.05 0.05 Seed treatment

Alfalfa, hay 0.12 0.12 Seed treatment

Food Handling Est. 0.01 0.02

Peanut 0.05 0.05 Seed treatment

Peanut, hay 0.25 0.25 Seed treatment

Peanut, meal None 0. 15 Seed treatment



## Acute Assessment

The acute assessment is based on tolerance leve l residues of thiamethoxam/clothianidin (the

tolerance is for combined residue s). The drinking water estimate for the acute analysis provided

in Table 2 includes residues of thiamethoxam from thiamethoxam uses, and is discussed in Section 3 below. A complete lis ting of the residues and proce ssing factors used in the acute analysis are included in Attachment 1.

Chronic Assessment

Most of the inputs are derived from HED’ s June 30, 2009 review for thiamethoxam (D364256, Dennis McNeilly) and updated with anticipated residues for the proposed peanut and food handling establishment uses. A complete listing of the residues and processing factors used in the chronic analysis are in Attachment 2.

The chronic assessment makes use of tolerance level residues (peanuts only), average residue values or the highest observed residue value from the thiamet hoxam field trials. Anticipated

residues were evaluated for selected commod ities only, which were listed in HED’s dietary analyses for thiamethoxam (D364256, D. McNeill y, 30 June 2009) and to which are added the

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 5 of 33 residue estimates for proposed us es on alfalfa, peanuts, and the food handling establishment treatment. Although monitoring data are available for some co mmodities, field trial residues were used for all the uses, along with a high end estimate of drinking water residues. Therefore this assessment is considered highly conservative.

Food Handling Establishments

The data supporting thiamethoxam use in food handling areas included a variety of food commodities exposed to thiamethoxam, in two di fferent types of food handling establishments, at 1X the maximum proposed rate. Ba sed on maximum thiamethoxam and CGA-322704 residues of <0.01 ppm in food commodities exposed to 1X treatment in food handling areas (the majority of samples had non-detectable residue s), HED recommends a tolerance of 0.02 ppm in food/feed commodities (other than those covere d by a higher tolerance as a result of use on growing crops) and will use an anticipated residue of 0.01 ppm in DEEM. All samples had residues values below the LOQ of <0.01, fo r both thiamethoxam and the metabolite CGA322704 (combined LOQ = 0.02 ppm).

Processing factors

There are no processed commodities associated w ith the proposed use on alfalfa or the use in food handling establishments. The processed commodities associated with the proposed use on peanuts are peanut meal (an animal feed item ) and refined oil. Reduction of thiamethoxam residues in peanut oil after processing ranged fr om 0.22x -0.40x; an average processing factor of

0.31x will be used in DEEM.

Empirical processing factors were used when available. For food forms without empirical processing factors, DEEM 7.81 default values were used. A complete listing of the empirical processing factors used can be f ound in Table 2 below. Note: Pr ocessing factors are not used and use of them would not be appropriate for residue estimates result ing from food handling

establishment use.

Livestock

HED has reevaluated the poultry di etary burden and determined that at the 1X feeding level, residues in poultry commodities would still be <L OQ. HED concludes that residues in eggs and poultry meat, fat, and meat byproducts remain a 40CFR §180.6[a][3] situation (there is no expectation of finite residues in these commodities). As a result, tolerances are still not required in any poultry commodities.

The dietary burden for cattle and/ or swine have not increased signi ficantly from those previously calculated. Therefore, the current tolerances in livestock commodities are still appropriate and the residue estimates for livestock commodities are as recommended in the previous

thiamethoxam risk assessment (D348703, M. Doherty, 25 Sept 2008).Thiamethoxam (060109) Dietary Exposureand Risk AssessmentDP Number 376368Page 6 of 33TABLE 2. INPUT TABLE FOR SELECTED THIAMETHOXAM COMMODITIES.RACBlendingClassificationDataSourceNo. ofSamplesNo. ofDetectableResiduesLOD orLOQ(Avg. inPPM)ReferenceProcessingFactors (PF)1Anticipated Residue Estimates/ToleranceChronic (Tol., AR)2Artichoke, globe NB/PB FT 6 6 <0.02D281702/D325447N/A 0.19Barley, grain B FT 16 10 <0.02D281702/D325447(PF Ref -D281702)0.3 pearled0.3 bran0.1 flour0.086Brassica, head and stem,subgroup 5-ANB/PBFT(cabbage)12 10 <0.02D281702/D325447N/A 0.98Brassica, leafy greens,subgroup 5-BNB/PBFT(mustardgreens)10 10 <0.02D281702/D325447N/A 0.82Caneberry subgroup13-APB FT 12 12 <0.02D281702/D325447N/A 0.12Citrus, fruits:OrangeGrapefruitLemonNB/PB FT281612271612<0.02 D3492720.6 oil0.6 juice0.100.070.09Food HandlingEstablishmentsNA FT42421838<0.02 D376367 NA 0.01Thiamethoxam (060109) Dietary Exposureand Risk AssessmentDP Number 376368Page 7 of 33TABLE 2. INPUT TABLE FOR SELECTED THIAMETHOXAM COMMODITIES.RACBlendingClassificationDataSourceNo. ofSamplesNo. ofDetectableResiduesLOD orLOQ(Avg. inPPM)ReferenceProcessingFactors (PF)1Anticipated Residue Estimates/ToleranceChronic (Tol., AR)2Fruit, pome, group 11 NB/PBFT (apple)FT (pear)26122610<0.02D281702/D325447& D2650790.75 juice0.060.06Fruit, stone, group 12CherryPeachPlumPBNB/PBNB/PBFTFTFT20202020198<0.02W. Cutchin,12/10/03 DERs1 prunes0.210.070.071Grape PB FT 24 22 <0.02D281702/D3254471.1 juice 0.06Grape, raisin PB FT (grape) 24 22 <0.02D281702/D325447PF – D2817022.3 0.06Peanut B FT 54 10 <0.02 D376367 0.31 oil 0.05Rice B FT 32 1 <0.02D357449/D357450PF – D3574490.9Polished rice0.01Soybeans B FT 30 0 <0.02D281702/D325447N/A 0.01Tree Nuts, group 14 PB FT 12 0 <0.02 D349272 N/A 0.01Thiamethoxam (060109) Dietary Exposureand Risk AssessmentDP Number 376368Page 8 of 33TABLE 2. INPUT TABLE FOR SELECTED THIAMETHOXAM COMMODITIES.RACBlendingClassificationDataSourceNo. ofSamplesNo. ofDetectableResiduesLOD orLOQ(Avg. inPPM)ReferenceProcessingFactors (PF)1Anticipated Residue Estimates/ToleranceChronic (Tol., AR)2Tropical Fruits NBFT(avocado)10 2 <0.02D357449/D357450N/A 0.11Vegetable, fruiting, group8TomatoPepperNB/PB FT4042-42<0.02<0.02D281702/D325447 +D265079PF – D265079Tomato puree1.7Tomato paste3.80.080.08Vegetable, legume, group6B/PBFTSnap beansLima beans161000<0.02S. Tadayon,26 Nov 2002N/A0.010.01Vegetable, root, subgroup1ANB/PB Tolerance N/AD357449/D357450Potato chips1.2Potato flakes1.70.05Water (direct, indirect) N/A EFED N/A N/A N/A N/A N/A Acute= 0.13177 ppm Chronic= 0.01131 ppm1 - The processing factors for existing uses are taken fromHED’s June 30, 2009 memo, the sources for these processing factors are cited in thereference column. An average processing of 0.31 for peanut oil is the only new processing factor associated with theproposed new uses.2 - Anticipated residues were calculated using 1⁄2 LOQ forall values below the LOQ.3- Separate analyses were conducted and reported for thiamethoxam and clothianidin. Each compound has an LOQ of 0.01 ppm, witha combinedLOQ of 0.02 ppm.

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 9 of 33 3. Drinking Water Data

The drinking water residues used in these di etary risk assessments were provided by EFED (D373378, C. Kopert, 20 May 2010), and incorporated directly into the di etary assessments. Water residues were incorporated in DEEM-F CID via entry into the food categories “water, direct, all sources” and “water, indirect, al l sources.” The estimated drinking water concentrations (EDWCs) in surface water are 0.13177 ppm and 0.01131 ppm for acute and chronic scenarios, respectively. Typically, HED uses the higher of the surface or groundwater estimates for each duration when assessing dietary risk, with the surface water (rice tail water) having higher values in this case.

The EDWCs were incorporated into the acu te and chronic thiamethoxam assessments. Clothianidin, a major metabolite of thiamethoxam in plants and livestock, is not a significant degradate of thiamethoxam in surface or gr oundwater sources of drinking water.

A Tier II screening-level drinking water assessm ent was conducted for the proposed new use on peanut and alfalfa seeds. EFED also evalua ted leafy vegetables, dry bulb onions and corn because previous assessments on these commodities were conducted at a lower application rate.

For surface water, the EDWCs for the crops mo deled in this assessment did not exceed the previous EDWCs for rice reported in the pr evious drinking water assessment (D363202, F. Khan, 07 April 2009). The reported acute concen tration of 131.77 μg/L, annual mean (chronic) concentration of 11.31 μg/L and the highest 30 y ear annual average concentration of 11.31 μg/L from the rice model are higher than the re ported EDWCs for various uses in Table 3. Therefore,

the current EDWCs for surface water do not su persede the drinking water concentrations previously estimated for this chemical (D363202).

For groundwater, based on the proposed highest annual use rate for dry bulb onions (0.3 lbs ai/acre) and the proposed rates for peanut seed (0.08 lbs ai/acre) and alfalfa seed (0.022 lbs ai/acre), the SCI-GROW model c oncentrations of thiamethoxam were 4.66 μg/L, 1.24 μg/L, and 0.34 μg/L, respectively. This value was compared to 4.14 μg/L reported for grapes in an earlier drinking water assessment (D329467) dated 10 January 2007. Since 4.66 μg/L for dry bulb onions is greater than 4.14 μg/L, the current EDWC supercedes the previously recommended EDWC for groundwater.

The acute scenario EDWC in surface water ( 0.13177 ppm) was obtained via exposure modeling

which utilized a modified Tier I Rice Model a nd the Provisional Cranberry Model. This model and its description are available at th e EPA internet website via the web link, http://www.epa.gov/oppefed1/models/water/

.

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 10 of 33 Table 3. Tier II Estimated Drinking Water Concentr ations (EDWCs) resulting from applications of

Thiamethoxam.

Drinking Water Source (model) Use

Scenario (modeled rate) 1-in-10 year acute (μg/L) 1-in-10 year chronic (μg/L) 30- year average (μg/L)

Surface Water (PRZM/EXAMS) NC Peanuts: (1 app. 1 

### X 0.08 lbs ai/acre) 1.51 0.16 0.05

CA Alfalfa (January 9)

MN Alfalfa (May 25)

NC Alfalfa (March 25)

PA Alfalfa (March 9)

TX Alfalfa (August 25)

IL Alfalfa (May 25) (all were 1 app. X 0.022 lbs. ai/acre) 0.37

0.27

0.55

0.37

0.89

0.58 0.07

0.03

0.08

0.05

0.10

0.06 0.03

0.02

0.03

0.03

0.05

0.03

Dry Bulb Onions:

CA Onion

GA Onion (1 app. X 0.3 lbs ai/acre) 1.57

20.45 0.25

1.54 0.06

0.44

Leafy Vegetables: CA Lettuce (1 run) (1 app. X 0.266 lbs. ai/acre) 23.78 3.68 1.29

Tail water (Rice Model) Rice (0.173 lbs ai/A/year) 131.77 1,2 

### 11.31 1,3 

### 11.31 1,3



### Cranberry (0.188 lbs ai/A/year) 54.75 2 

### 4.50 3 

### 4.50 3



### Groundwater (SCI-GROW) Peanuts: (1 app. X 0.08 lbs ai/acre) 

### 1.24 1.24 1.24

Alfalfa: (1 app. X 0.022 lbs. ai/acre) 0.34 0.34 0.34

Dry bulb onions: (1 app. X 0.30 lbs. ai/acre) 4.66 4.66 4.66

Bold text denotes maximum estimated EDWC values. All values adjusted with PCA factor of 0.87.



## 1 Recommended EDWCs for surface water.

2 EDWCs based on day 1.

3 EWDCs based on average of 365 days.

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 11 of 33 Water Monitoring Data

Only very limited monitoring data are available for thiamethoxam and these data are discussed

below ; 

## due to this limitation HED used modeling data for the dr inking water residue estimate for both the acute and chronic dietary risk assessments.

Two small-scale prospective ground water (PGW) monitoring studies were initiated in southwest Michigan in June 2001 and southwestern Geor gia in the spring of 2002, to determine the potential for the active ingredient thiamethoxam and its degradates to reach groundwater when used in a vulnerable hydrogeologic setting. Analyti cal data were collected for 47 months (from treatment in the spring of 2001 until May 2005) in the Michigan study and for 36 months (from treatment in the spring of 2002 until May 2005) in the Georgia study.

In Michigan, thiamethoxam residues found in soil -pore water samples have clearly peaked and then declined. No quantifiable residues of thiamethoxam > LOQ (0.05 ppb) were observed in any of the 3, 6, and 9-ft lysimeters after the 36, 16, and 41-MAT sampling events, respectively. By the 47-MAT sampling event only trace level detec tions of thiamethoxam were observed in three of the 15-ft. lysimeter units (m aximum concentration 0.11 ppb).

In Georgia, thiamethoxam residue s have only been confirmed in four shallow monitoring wells (MW-1S, MW-3S, MW-5S, and MW-8S) dur ing 47 months of sampling. Thiamethoxam residues in groundwater peaked at 43-MAT, a nd by 47-MAT residues were confined to two shallow monitoring wells only (maximum c oncentration 0.12 ppb). No detections of thiamethoxam at or greater than the analyti cal method LOQ have been observed in any groundwater samples collected from the deep monitoring wells during 47 months of sampling.

4. DEEM-FCIDTM Program and Consumption Information

Thiamethoxam acute and chronic dietary exposur e assessments were conducted using DEEMFCIDTM (Version 2.03), which incorporates cons umption data from USDA’s CSFII, 1994 to 1996, and 1998. The 1994-96, 1998 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” (such as apple pie) are linked to EPA-defined food commoditie s (such as apples, peeled fruit - cooked, fresh/unspecified, or baked; or wheat flour - cooked, fresh/unspeci fied, or baked) using publicly available recipe translation files develope d jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are aver aged for the entire US population, and within population subgroups, but for acute exposure assessm ent, they are retained as individual consumption events (which is why it is appropriat e to add residue values together for the acute assessment, while separate exposure estimates ar e summed for the chronic assessment). Based on analysis of the 1994-96, 1998 CSFII consumpti on data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general US populat ion, all infants (<1 year old), children 1- 2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years

old.

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 12 of 33 For chronic dietary exposure assessment, an esti mate of the residue level in each food or foodform (such as orange or orange juice) on th e food commodity residue list is multiplied by the average daily consumption estimate for that food/ food form. The resultin g residue consumption

estimate for each food/food form is summed with the residue consumption estimates for all other food/food forms on the commodity resi due list to arrive at the tota l average estimated exposure. Exposure is expressed in mg/kg body weight/day, and as a percent of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-d ay food consumption data are used on an individual-by-individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate, and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “match ed” in multiple random pairings with residue values, and then summed in a probabilistic assessme nt. The resulting distribution of exposures is expressed as a percentage of the aPAD on bot h a user (those who reported eating relevant commodities/food forms) and a pe r-capita (those who reported ea ting the relevant commodities as well as those who did not) basis. In accordan ce with HED policy, per capita exposure and risk are reported for all tiers of analys is. However, for Tiers 1 and 2, significant differences in user versus per capita exposure and risk are identif ied, and noted in the risk assessment.

5. Toxicological Information

The toxicology database for thiamethoxam is comp lete. The scientific quality is relatively high and the toxicity profile of thiamethoxam can be characterized for most effects, including potential carcinogenic, mu tagenic, developmental, and neurotoxic effects.

The Agency has determined that the 10X FQPA safety factor fo r the protection of infants and children can be reduced to 1X. There is no qua ntitative or qualitative evidence of increased susceptibility of rat or rabbit fetuses to in utero exposure to thiamethoxam in the developmental toxicity studies. The developmental NOAELs are either higher than or equal to the maternal NOAELs. The Developmental Neurotoxity (DNT ) Workgroup concluded there was no evidence of increased quantitative susceptibility in the DNT study in rats, based on evaluation of additional brain morphometric data for the low- and mid-dose pups (January 17, 2007 meeting).

Although there is evidence of increased quantitative suscepti bility for male pups of both two generation reproductive studies, NOAELs and LOAELs were established in these studies, and the Agency selected the NOAEL for te sticular effects in F1 pups as the basis for risk assessment. The Agency is confident that the NOAEL selected for risk assessment is protective of the most sensitive effect (testicular effects) for th e most sensitive subgroup (pups) observed in the toxicological database.

In addition, the NOAELs selected for risk assessment are protectiv e of all toxicological effects

observed in the database includi ng treatment-related changes in th e adrenal gland, thyroid, testes

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 13 of 33 and ovaries. Thus, the Agency believes the FQPA sa fety factor can be reduced to 1X and still be conservatively protective of human health risk.

Table 4. Toxicological Doses and Endpoints for Thiamethoxam for Use in Human Health Risk Assessments.

Exposure/

Scenario Point of Departure Uncertainty/ FQPA Safety Factors Level of Concern

for Risk

Assessment Study and Toxicological Effects

Acute Dietary All populations including

infants and

children NOAEL =

34.5 mg/kg/day UF A 

### = 10x

UF H 

### = 10x

SF FQPA 

### =1 aRfD=0.35 mg/kg/day

aPAD=0.35 mg/kg/day Rat Developmental Neurotoxicity study LOAEL = 298.7 mg/kg/day based on delayed sexual maturation in male pups, and reduced brain morphometric measurements.

Chronic Dietary All populations including

infants and

children NOAEL= 1.2 mg/kg/day

( MRID

46402904 

### ) UF A 

### = 10x

UF H 

### = 10x

SF FQPA 

### =1 cRfD=0.012 mg/kg/day

cPAD=0.012 mg/kg/day 2-Generation reproduction study LOAEL = 1.8 mg/kg/day based on increased incidence and severity of tubular atrophy in testes of F1 generation males.

2-Generation reproduction study (46402904)
LOAEL = 3 (males), not determined (females) mg/kg/day based on sperm abnormalities in F1 males.
Cancer (oral, dermal, inhalation) “Not Likely to be Carcinogenic to Humans” based on convincing evidence that a nongenotoxic mode of action for liver tumors was established in the mouse and that the carcinogenic effects are a result of a mode of action dependent on sufficient amounts of a hepatotoxic metabolite produced persistently. Quantification of cancer risk is not required.



## 6. Results/Discussion

As previously stated, for acute and chronic asse ssments, HED is concerned when dietary risk

exceeds 100% of the PAD. The DEEM-FCIDTM anal yses estimate the dietary exposure of the US population and various population subgroups. Th e results of the assessments are shown in Table 5, below.

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 14 of 33 Table 5. Summary of Estimated Dietary (Food + Drin king Water) Exposures and Risk for Thiamethoxam.

Population Subgroup aPAD, mg/kg/day Acute Estimates (95 th


### Percentile) 1 

### cPAD, mg/kg/day Chronic Estimates

Exposure, mg/kg/day Risk, % aPAD Exposure, mg/kg/day Risk, % cPAD

U.S. Population 0.35 0.018094 5.2 0.012 0.002825 24
All infants (< 1 year) 2 

### 0.35 0.033165 9.5 0.012 0.003052 25
Children 1-2 yrs 0.35 0.032947 9.4 0.012 0.005150 43
Children 3-5 yrs 0.35 0.026627 7.6 0.012 0.004520 38
Children 6-12 yrs 0.35 0.018819 5.4 0.012 0.003241 27
Youth 13-19 yrs 0.35 0.014311 4.1 0.012 0.002333 19
Adults 20-49 yrs 0.35 0.016277 4.7 0.012 0.002591 22
Adults 50+ yrs 0.35 0.016617 4.8 0.012 0.002648 22
Females 13-49 yrs 0.35 0.16123 4.6 0.012 0.002617 22

1 - Results for the 99 th 

### and 99.9 th 

### percentile are reported in Attachment 3. 2 - The population subgroup with the highest estimated exposure/risk is bolded.



## As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. population and various population subgroups. The resu lts reported in Table 5 are for the general U.S. population, all infants (<1 year old), child ren 1-2, children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50+ years. The acute results summarized in Table 6 are

for the 95 th 

## percentile of exposure. A complete listing of acute a nd chronic exposure and risk

estimates can be found in Att achments 2 and 3, respectively.

The analyses indicate that the re quested uses of thiamethoxam, c oupled with currently registered uses, will result in acute and chronic dietary (f ood + drinking water) exposures that are below HED’s level of concern for all population subgrou ps, including those of infants and children.

Typically, HED uses tolerance-level residues in its most conservative assessments. For this reason, the acute assessment is considered to be an unrefined assessment (i.e., screening level)

and evaluation at the 95 th 

## percentile of exposure is appropriate. The acute assessment indicates that All Infants are the most highly-exposed subgroup, utilizing 9.5% of the aPAD, while the general US population utilizes 5.2 % of the aPAD; all risk estimat es are below HED’s level of concern (Table 5). Similarly, risk estimates fo r the chronic dietary expos ure analysis are below HED’s level of concern, with Children 1-2 y ears being the most highly-exposed subgroup, utilizing 43% of the chronic popul ation-adjusted dose (cPAD), wh ile the general U.S. population

utilizes 24% of the cPAD.

7. Characterization of Inputs/Outputs

This assessment is based on tolerance level or anticipated residues derived from field trial residue data and assumes 100% CT. The expos ure values represent high-end estimates and

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 15 of 33 should be considered highly conservative, hea lth-protective estimates of dietary exposure and risk. The Tier I Rice Model used to generate the EDWCs is expected to generate conservative estimates that exceed peak measured concentr ations of pesticides in water bodies well downstream of rice paddies by less than one order of magnitude to multiple orders of magnitude.

8. Conclusions

Based on highly conservative assumptions, there are no dietary (food + dr inking water) exposure considerations that would preclud e registration of thiamethoxam on al falfa, peanuts and/or use in food handling establishments.

9. List of Attachments

Attachment 1. Input file for the acute di etary exposure analyses of thiamethoxam. Attachment 2. Input file for the chronic dietary exposure analyses of thiamethoxam. Attachment 3. Summary of the acute diet ary exposure analysis for thiamethoxam. Attachment 4. Summary of the chronic di etary exposure analysis for thiamethoxam.

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 16 of 33 Attachment 1. Input File for the Acute Dietary Exposure Estimates.

U.S. Environmental Protection Agency Ver. 2.02 DEEM-FCID Acute analysis for THIAMETHOXAM Residue file name: C:\Documents and Settings\dmcneill\My Documents\Thiamethoxam_3\060109 2010 Acute T+Water.R98 Analysis Date 10-28-2010 Residue file dated: 10-28-2010/09:42:38 Reference dose (aRfD) = 0.35 mg/kg bw/day

Comment: Acute and Chronic RfDs = aPAD and cPAD

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Food Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 14000030 14 Almond 0.020000 1.000 1.000 14000031 14 Almond-babyfood 0.020000 1.000 1.000 14000040 14 Almond, oil 0.020000 1.000 1.000 14000041 14 Almond, oil-babyfood 0.020000 1.000 1.000 04010050 4A Amaranth, leafy 4.000000 1.000 1.000 11000070 11 Apple, fruit with peel 0.200000 1.000 1.000 11000080 11 Apple, peeled fruit 0.200000 1.000 1.000 11000081 11 Apple, peeled fruit-babyfood 0.200000 1.000 1.000 11000090 11 Apple, dried 0.200000 8.000 1.000 11000091 11 Apple, dried-babyfood 0.200000 8.000 1.000 11000100 11 Apple, juice 0.200000 0.750 1.000 11000101 11 Apple, juice-babyfood 0.200000 0.750 1.000 11000110 11 Apple, sauce 0.200000 1.000 1.000 11000111 11 Apple, sauce-babyfood 0.200000 1.000 1.000 12000120 12 Apricot 0.500000 1.000 1.000 12000121 12 Apricot-babyfood 0.500000 1.000 1.000 12000130 12 Apricot, dried 0.500000 6.000 1.000 12000140 12 Apricot, juice 0.500000 1.000 1.000 12000141 12 Apricot, juice-babyfood 0.500000 1.000 1.000 95000160 O Artichoke, globe 0.450000 1.000 1.000 04010180 4A Arugula 4.000000 1.000 1.000

95000200 O Avocado 0.400000 1.000 1.000 09020210 9B Balsam pear 0.200000 1.000 1.000 15000250 15 Barley, pearled barley 0.300000 0.300 1.000

Full comment: D281702 15000251 15 Barley, pearled barley-babyfood 0.300000 0.300 1.000

Full comment: D281702 15000260 15 Barley, flour 0.300000 0.100 1.000

Full comment: D281702 15000261 15 Barley, flour-babyfood 0.300000 0.100 1.000

Full comment: D281702 15000270 15 Barley, bran 0.300000 0.300 1.000

Full comment: D281702 06030300 6C Bean, black, seed 0.020000 1.000 1.000 06020310 6B Bean, broad, succulent 0.020000 1.000 1.000 06030320 6C Bean, broad, seed 0.020000 1.000 1.000 06020330 6B Bean, cowpea, succulent 0.020000 1.000 1.000 06030340 6C Bean, cowpea, seed 0.020000 1.000 1.000 06030350 6C Bean, great northern, seed 0.020000 1.000 1.000 06030360 6C Bean, kidney, seed 0.020000 1.000 1.000 06020370 6B Bean, lima, succulent 0.020000 1.000 1.000 06030380 6C Bean, lima, seed 0.020000 1.000 1.000 06030390 6C Bean, mung, seed 0.020000 1.000 1.000 06030400 6C Bean, navy, seed 0.020000 1.000 1.000 06030410 6C Bean, pink, seed 0.020000 1.000 1.000 06030420 6C Bean, pinto, seed 0.020000 1.000 1.000 06010430 6A Bean, snap, succulent 0.020000 1.000 1.000 06010431 6A Bean, snap, succulent-babyfood 0.020000 1.000 1.000 21000440 M Beef, meat 0.020000 1.000 1.000 21000441 M Beef, meat-babyfood 0.020000 1.000 1.000 21000450 M Beef, meat, dried 0.020000 1.920 1.000 21000460 M Beef, meat byproducts 0.040000 1.000 1.000 21000461 M Beef, meat byproducts-babyfood 0.040000 1.000 1.000

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 17 of 33 21000480 M Beef, kidney 0.040000 1.000 1.000 21000490 M Beef, liver 0.040000 1.000 1.000 21000491 M Beef, liver-babyfood 0.040000 1.000 1.000 01010500 1AB Beet, garden, roots 0.050000 1.000 1.000 Full comment: D357449, recommended tol. 01010501 1AB Beet, garden, roots-babyfood 0.050000 1.000 1.000 01010520 1A Beet, sugar 0.050000 1.000 1.000 01010521 1A Beet, sugar-babyfood 0.050000 1.000 1.000 01010530 1A Beet, sugar, molasses 0.050000 1.000 1.000 01010531 1A Beet, sugar, molasses-babyfood 0.050000 1.000 1.000 13010550 13A Blackberry 0.350000 1.000 1.000 13010560 13A Blackberry, juice 0.350000 1.000 1.000 13010561 13A Blackberry, juice-babyfood 0.350000 1.000 1.000 13020570 13B Blueberry 0.300000 1.000 1.000 13020571 13B Blueberry-babyfood 0.300000 1.000 1.000 13010580 13A Boysenberry 0.350000 1.000 1.000
14000590 14 Brazil nut 0.020000 1.000 1.000
05010610 5A Broccoli 4.500000 1.000 1.000 05010611 5A Broccoli-babyfood 4.500000 1.000 1.000 05010620 5A Broccoli, Chinese 4.500000 1.000 1.000
05020630 5B Broccoli raab 3.000000 1.000 1.000 05010640 5A Brussels sprouts 4.500000 1.000 1.000

15000650 15 Buckwheat 0.020000 1.000 1.000 15000660 15 Buckwheat, flour 0.020000 1.000 1.000

01010670 1AB Burdock 0.050000 1.000 1.000

14000680 14 Butternut 0.020000 1.000 1.000 05010690 5A Cabbage 4.500000 1.000 1.000 05020700 5B Cabbage, Chinese, bok choy 3.000000 1.000 1.000 05010710 5A Cabbage, Chinese, napa 4.500000 1.000 1.000 05010720 5A Cabbage, Chinese, mustard 4.500000 1.000 1.000
95000740 O Canistel 0.400000 1.000 1.000 09010750 9A Cantaloupe 0.200000 1.000 1.000

04020760 4B Cardoon 4.000000 1.000 1.000

01010780 1AB Carrot 0.050000 1.000 1.000 01010781 1AB Carrot-babyfood 0.050000 1.000 1.000 01010790 1AB Carrot, juice 0.050000 1.000 1.000

09010800 9A Casaba 0.200000 1.000 1.000

14000810 14 Cashew 0.020000 1.000 1.000
05010830 5A Cauliflower 4.500000 1.000 1.000
01010840 1AB Celeriac 0.050000 1.000 1.000 04020850 4B Celery 4.000000 1.000 1.000 04020851 4B Celery-babyfood 4.000000 1.000 1.000 04020860 4B Celery, juice 4.000000 1.000 1.000

04020870 4B Celtuce 4.000000 1.000 1.000 09020880 9B Chayote, fruit 0.200000 1.000 1.000 95000890 O Cherimoya 0.110000 1.000 1.000 12000900 12 Cherry 0.500000 1.000 1.000 12000901 12 Cherry-babyfood 0.500000 1.000 1.000 12000910 12 Cherry, juice 0.500000 1.500 1.000 12000911 12 Cherry, juice-babyfood 0.500000 1.500 1.000

14000920 14 Chestnut 0.020000 1.000 1.000 06030980 6C Chickpea, seed 0.020000 1.000 1.000 06030981 6C Chickpea, seed-babyfood 0.020000 1.000 1.000 06030990 6C Chickpea, flour 0.020000 1.000 1.000 01011000 1AB Chicory, roots 0.050000 1.000 1.000 09021020 9B Chinese waxgourd 0.200000 1.000 1.000 04011040 4A Chrysanthemum, garland 4.000000 1.000 1.000
10001060 10 Citrus citron 0.400000 1.000 1.000

Full comment: D348703 10001070 10 Citrus hybrids 0.400000 1.000 1.000 10001080 10 Citrus, oil 0.400000 0.600 1.000

Full comment: D349272 95001150 O Coffee, roasted bean 0.050000 1.000 1.000 95001160 O Coffee, instant 0.050000 1.000 1.000

05021170 5B Collards 3.000000 1.000 1.000 15001200 15 Corn, field, flour 0.020000 1.000 1.000 15001201 15 Corn, field, flour-babyfood 0.020000 1.000 1.000

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 18 of 33 15001210 15 Corn, field, meal 0.020000 1.000 1.000 15001211 15 Corn, field, meal-babyfood 0.020000 1.000 1.000 15001220 15 Corn, field, bran 0.020000 1.000 1.000 15001230 15 Corn, field, starch 0.020000 1.000 1.000 15001231 15 Corn, field, starch-babyfood 0.020000 1.000 1.000 15001240 15 Corn, field, syrup 0.020000 1.500 1.000 15001241 15 Corn, field, syrup-babyfood 0.020000 1.500 1.000 15001250 15 Corn, field, oil 0.020000 1.000 1.000 15001251 15 Corn, field, oil-babyfood 0.020000 1.000 1.000 15001260 15 Corn, pop 0.020000 1.000 1.000 15001270 15 Corn, sweet 0.020000 1.000 1.000 15001271 15 Corn, sweet-babyfood 0.020000 1.000 1.000 95001280 O Cottonseed, oil 0.100000 1.000 1.000 95001281 O Cottonseed, oil-babyfood 0.100000 1.000 1.000 11001290 11 Crabapple 0.200000 1.000 1.000 95001300 O Cranberry 0.020000 1.000 1.000 95001301 O Cranberry-babyfood 0.020000 1.000 1.000 95001310 O Cranberry, dried 0.020000 1.000 1.000 95001320 O Cranberry, juice 0.020000 1.100 1.000 95001321 O Cranberry, juice-babyfood 0.020000 1.100 1.000 04011330 4A Cress, garden 4.000000 1.000 1.000 04011340 4A Cress, upland 4.000000 1.000 1.000

09021350 9B Cucumber 0.200000 1.000 1.000

13021360 13B Currant 0.200000 1.000 1.000 13021370 13B Currant, dried 0.200000 1.000 1.000 04011380 4A Dandelion, leaves 4.000000 1.000 1.000 13011420 13A Dewberry 0.350000 1.000 1.000 08001480 8 Eggplant 0.250000 1.000 1.000 13021490 13B Elderberry 0.200000 1.000 1.000
04011500 4A Endive 4.000000 1.000 1.000 04021520 4B Fennel, Florence 4.000000 1.000 1.000
14001550 14 Filbert 0.020000 1.000 1.000 14001560 14 Filbert, oil 0.020000 1.000 1.000 20001630 20 Flaxseed, oil 0.020000 1.000 1.000 01011680 1AB Ginseng, dried 0.050000 1.000 1.000
23001690 M Goat, meat 0.020000 1.000 1.000 23001700 M Goat, meat byproducts 0.040000 1.000 1.000 23001720 M Goat, kidney 0.040000 1.000 1.000 23001730 M Goat, liver 0.040000 1.000 1.000 13021740 13B Gooseberry 0.200000 1.000 1.000 95001750 O Grape 0.200000 1.000 1.000 95001760 O Grape, juice 0.200000 1.100 1.000

Full comment: D281702 95001761 O Grape, juice-babyfood 0.200000 1.100 1.000 95001770 O Grape, leaves 0.200000 1.000 1.000 95001780 O Grape, raisin 0.200000 2.300 1.000

Full comment: D281702 95001790 O Grape, wine and sherry 0.200000 1.000 1.000 10001800 10 Grapefruit 0.400000 1.000 1.000 10001810 10 Grapefruit, juice 0.400000 0.600 1.000

Full comment: D349272 06031820 6C Guar, seed 0.020000 1.000 1.000 06031821 6C Guar, seed-babyfood 0.020000 1.000 1.000 14001850 14 Hickory nut 0.020000 1.000 1.000 09011870 9A Honeydew melon 0.200000 1.000 1.000 95001880 O Hop 0.100000 1.000 1.000 24001890 M Horse, meat 0.020000 1.000 1.000 01011900 1AB Horseradish 0.050000 1.000 1.000 13021910 13B Huckleberry 0.200000 1.000 1.000

05021940 5B Kale 3.000000 1.000 1.000
05011960 5A Kohlrabi 4.500000 1.000 1.000 10001970 10 Kumquat 0.400000 1.000 1.000

10001990 10 Lemon 0.400000 1.000 1.000 10002000 10 Lemon, juice 0.400000 0.600 1.000

Full comment: D348272 10002001 10 Lemon, juice-babyfood 0.400000 0.600 1.000

Full comment: D349272

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 19 of 33 10002010 10 Lemon, peel 0.400000 1.000 1.000 06032030 6C Lentil, seed 0.020000 1.000 1.000 04012040 4A Lettuce, head 4.000000 1.000 1.000 04012050 4A Lettuce, leaf 4.000000 1.000 1.000
10002060 10 Lime 0.400000 1.000 1.000 10002070 10 Lime, juice 0.400000 0.600 1.000

Full comment: D348272 10002071 10 Lime, juice-babyfood 0.400000 0.600 1.000

Full comment: D349272 13012080 13A Loganberry 0.350000 1.000 1.000 11002100 11 Loquat 0.200000 1.000 1.000 14002130 14 Macadamia nut 0.020000 1.000 1.000 95002150 O Mango 0.400000 1.000 1.000 95002151 O Mango-babyfood 0.400000 1.000 1.000 95002160 O Mango, dried 0.400000 1.000 1.000 95002170 O Mango, juice 0.400000 1.000 1.000 95002171 O Mango, juice-babyfood 0.400000 1.000 1.000 28002210 M Meat, game 0.020000 1.000 1.000 27002220 D Milk, fat 0.020000 1.000 1.000 27002221 D Milk, fat - baby food/infant for 0.020000 1.000 1.000 27012230 D Milk, nonfat solids 0.020000 1.000 1.000 27012231 D Milk, nonfat solids-baby food/in 0.020000 1.000 1.000 27022240 D Milk, water 0.020000 1.000 1.000 27022241 D Milk, water-babyfood/infant form 0.020000 1.000 1.000 27032251 D Milk, sugar (lactose)-baby food/ 0.020000 1.000 1.000 15002260 15 Millet, grain 0.020000 1.000 1.000 05022290 5B Mustard greens 3.000000 1.000 1.000
12002300 12 Nectarine 0.500000 1.000 1.000 15002310 15 Oat, bran 0.020000 1.000 1.000 15002320 15 Oat, flour 0.020000 1.000 1.000 15002321 15 Oat, flour-babyfood 0.020000 1.000 1.000 15002330 15 Oat, groats/rolled oats 0.020000 1.000 1.000 15002331 15 Oat, groats/rolled oats-babyfood 0.020000 1.000 1.000

08002340 8 Okra 0.250000 1.000 1.000 03002370 3 Onion, dry bulb 0.030000 1.000 1.000 03002371 3 Onion, dry bulb-babyfood 0.030000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0.030000 9.000 1.000 03002381 3 Onion, dry bulb, dried-babyfood 0.030000 9.000 1.000 10002400 10 Orange 0.400000 1.000 1.000 10002410 10 Orange, juice 0.400000 0.600 1.000

Full comment: D349272 10002411 10 Orange, juice-babyfood 0.400000 0.600 1.000

Full comment: D348272 10002420 10 Orange, peel 0.400000 1.000 1.000 95002450 O Papaya 0.400000 1.000 1.000 95002451 O Papaya-babyfood 0.400000 1.000 1.000 95002460 O Papaya, dried 0.400000 1.800 1.000 95002470 O Papaya, juice 0.400000 1.500 1.000 04012480 4A Parsley, leaves 4.000000 1.000 1.000 01012500 1AB Parsley, turnip rooted 0.050000 1.000 1.000 01012510 1AB Parsnip 0.050000 1.000 1.000 01012511 1AB Parsnip-babyfood 0.050000 1.000 1.000 06022550 6B Pea, succulent 0.020000 1.000 1.000 06022551 6B Pea, succulent-babyfood 0.020000 1.000 1.000 06032560 6C Pea, dry 0.020000 1.000 1.000 06032561 6C Pea, dry-babyfood 0.020000 1.000 1.000 06012570 6A Pea, edible podded, succulent 0.020000 1.000 1.000 06032580 6C Pea, pigeon, seed 0.020000 1.000 1.000 06022590 6B Pea, pigeon, succulent 0.020000 1.000 1.000

12002600 12 Peach 0.500000 1.000 1.000 12002601 12 Peach-babyfood 0.500000 1.000 1.000 12002610 12 Peach, dried 0.500000 7.000 1.000 12002611 12 Peach, dried-babyfood 0.500000 7.000 1.000 12002620 12 Peach, juice 0.500000 1.000 1.000 12002621 12 Peach, juice-babyfood 0.500000 1.000 1.000

95002630 O Peanut 0.050000 1.000 1.000 95002640 O Peanut, butter 0.050000 1.890 1.000

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 20 of 33 95002650 O Peanut, oil 0.050000 0.310 1.000

Full comment: D376367

11002660 11 Pear 0.200000 1.000 1.000 11002661 11 Pear-babyfood 0.200000 1.000 1.000 11002670 11 Pear, dried 0.200000 6.250 1.000 11002680 11 Pear, juice 0.200000 1.000 1.000 11002681 11 Pear, juice-babyfood 0.200000 1.000 1.000

14002690 14 Pecan 0.020000 1.000 1.000 08002700 8 Pepper, bell 0.250000 1.000 1.000 08002701 8 Pepper, bell-babyfood 0.250000 1.000 1.000 08002710 8 Pepper, bell, dried 0.250000 1.000 1.000 08002711 8 Pepper, bell, dried-babyfood 0.250000 1.000 1.000 08002720 8 Pepper, nonbell 0.250000 1.000 1.000 08002721 8 Pepper, nonbell-babyfood 0.250000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.250000 1.000 1.000 95002750 O Peppermint 1.500000 1.000 1.000 95002760 O Peppermint, oil 1.500000 0.050 1.000
14002820 14 Pistachio 0.020000 1.000 1.000

12002850 12 Plum 0.500000 1.000 1.000 12002851 12 Plum-babyfood 0.500000 1.000 1.000 12002860 12 Plum, prune, fresh 0.500000 1.000 1.000 12002861 12 Plum, prune, fresh-babyfood 0.500000 1.000 1.000 12002870 12 Plum, prune, dried 0.500000 5.000 1.000 12002871 12 Plum, prune, dried-babyfood 0.500000 5.000 1.000 12002880 12 Plum, prune, juice 0.500000 1.400 1.000 12002881 12 Plum, prune, juice-babyfood 0.500000 1.400 1.000 25002900 M Pork, meat 0.020000 1.000 1.000 25002901 M Pork, meat-babyfood 0.020000 1.000 1.000 25002920 M Pork, meat byproducts 0.020000 1.000 1.000 25002921 M Pork, meat byproducts-babyfood 0.020000 1.000 1.000 25002940 M Pork, kidney 0.020000 1.000 1.000 25002950 M Pork, liver 0.020000 1.000 1.000 01032960 1C Potato, chips 0.250000 1.200 1.000 01032970 1C Potato, dry (granules/ flakes) 0.250000 1.700 1.000 01032971 1C Potato, dry (granules/ flakes)-b 0.250000 1.700 1.000
01032980 1C Potato, flour 0.250000 1.700 1.000 01032981 1C Potato, flour-babyfood 0.250000 1.700 1.000 01032990 1C Potato, tuber, w/peel 0.250000 1.000 1.000 01032991 1C Potato, tuber, w/peel-babyfood 0.250000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 0.250000 1.000 1.000 01033001 1C Potato, tuber, w/o peel-babyfood 0.250000 1.000 1.000

10003070 10 Pummelo 0.400000 1.000 1.000 09023080 9B Pumpkin 0.200000 1.000 1.000 09023090 9B Pumpkin, seed 0.200000 1.000 1.000 11003100 11 Quince 0.200000 1.000 1.000 29003120 M Rabbit, meat 0.020000 1.000 1.000
04013130 4A Radicchio 4.000000 1.000 1.000 01013140 1AB Radish, roots 0.050000 1.000 1.000 02003150 2 Radish, tops 0.800000 1.000 1.000 01013160 1AB Radish, Oriental, roots 0.050000 1.000 1.000 02003170 2 Radish, Oriental, tops 0.800000 1.000 1.000 05023180 5B Rape greens 3.000000 1.000 1.000 20003190 20 Rapeseed, oil 0.020000 1.000 1.000 20003191 20 Rapeseed, oil-babyfood 0.020000 1.000 1.000 13013200 13A Raspberry 0.350000 1.000 1.000 13013201 13A Raspberry-babyfood 0.350000 1.000 1.000 13013210 13A Raspberry, juice 0.350000 1.000 1.000 13013211 13A Raspberry, juice-babyfood 0.350000 1.000 1.000

04023220 4B Rhubarb 4.000000 1.000 1.000 15003230 15 Rice, white 0.020000 1.000 1.000 15003231 15 Rice, white-babyfood 0.020000 1.000 1.000 15003240 15 Rice, brown 0.020000 1.000 1.000 15003241 15 Rice, brown-babyfood 0.020000 1.000 1.000 15003250 15 Rice, flour 0.020000 1.000 1.000 15003251 15 Rice, flour-babyfood 0.020000 1.000 1.000 15003260 15 Rice, bran 0.020000 0.900 1.000

Full comment: D357449

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 21 of 33 15003261 15 Rice, bran-babyfood 0.020000 0.900 1.000

Full comment: D357449 01013270 1AB Rutabaga 0.050000 1.000 1.000 15003280 15 Rye, grain 0.020000 1.000 1.000 15003290 15 Rye, flour 0.020000 1.000 1.000 20003300 20 Safflower, oil 0.020000 1.000 1.000 20003301 20 Safflower, oil-babyfood 0.020000 1.000 1.000 01013310 1AB Salsify, roots 0.050000 1.000 1.000 95003330 O Sapote, Mamey 0.400000 1.000 1.000 26003390 M Sheep, meat 0.020000 1.000 1.000 26003391 M Sheep, meat-babyfood 0.020000 1.000 1.000 26003400 M Sheep, meat byproducts 0.040000 1.000 1.000 26003420 M Sheep, kidney 0.040000 1.000 1.000 26003430 M Sheep, liver 0.040000 1.000 1.000 15003440 15 Sorghum, grain 0.020000 1.000 1.000 15003450 15 Sorghum, syrup 0.020000 1.000 1.000 06003470 6 Soybean, seed 0.020000 1.000 1.000 06003480 6 Soybean, flour 0.020000 1.000 1.000 06003481 6 Soybean, flour-babyfood 0.020000 1.000 1.000 06003490 6 Soybean, soy milk 0.020000 1.000 1.000 06003491 6 Soybean, soy milk-babyfood or in 0.020000 1.000 1.000 06003500 6 Soybean, oil 0.020000 1.000 1.000 06003501 6 Soybean, oil-babyfood 0.020000 1.000 1.000 95003520 O Spearmint 1.500000 1.000 1.000 95003530 O Spearmint, oil 1.500000 0.050 1.000

Full comment: D281702 04013550 4A Spinach 4.000000 1.000 1.000 04013551 4A Spinach-babyfood 4.000000 1.000 1.000 09023560 9B Squash, summer 0.200000 1.000 1.000 09023561 9B Squash, summer-babyfood 0.200000 1.000 1.000 09023570 9B Squash, winter 0.200000 1.000 1.000 09023571 9B Squash, winter-babyfood 0.200000 1.000 1.000 95003590 O Strawberry 0.300000 1.000 1.000 95003591 O Strawberry-babyfood 0.300000 1.000 1.000 95003600 O Strawberry, juice 0.300000 1.000 1.000 95003601 O Strawberry, juice-babyfood 0.300000 1.000 1.000 20003640 20 Sunflower, seed 0.020000 1.000 1.000 20003650 20 Sunflower, oil 0.020000 1.000 1.000 20003651 20 Sunflower, oil-babyfood 0.020000 1.000 1.000 01033660 1CD Sweet potato 0.020000 1.000 1.000 01033661 1CD Sweet potato-babyfood 0.020000 1.000 1.000
04023670 4B Swiss chard 4.000000 1.000 1.000 10003690 10 Tangerine 0.400000 1.000 1.000 10003700 10 Tangerine, juice 0.400000 0.600 1.000

Full comment: D348272 01033710 1CD Tanier, corm 0.020000 1.000 1.000
08003740 8 Tomatillo 0.250000 1.000 1.000

08003750 8 Tomato 0.250000 1.000 1.000 08003751 8 Tomato-babyfood 0.250000 1.000 1.000 08003760 8 Tomato, paste 0.800000 1.000 1.000 Tol. 08003761 8 Tomato, paste-babyfood 0.800000 1.000 1.000 Tol. 08003770 8 Tomato, puree 0.250000 1.700 1.000 08003771 8 Tomato, puree-babyfood 0.250000 1.700 1.000 08003780 8 Tomato, dried 0.250000 14.300 1.000 08003781 8 Tomato, dried-babyfood 0.250000 14.300 1.000 08003790 8 Tomato, juice 0.250000 1.500 1.000 15003810 15 Triticale, flour 0.020000 1.000 1.000 15003811 15 Triticale, flour-babyfood 0.020000 1.000 1.000
01033870 1CD Turmeric 0.020000 1.000 1.000 01013880 1AB Turnip, roots 0.050000 1.000 1.000 05023890 5B Turnip, greens 3.000000 1.000 1.000

14003910 14 Walnut 0.020000 1.000 1.000 86010000 O Water, direct, all sources 0.131770 1.000 1.000

Full comment: D373378 86020000 O Water, indirect, all sources 0.131770 1.000 1.000

Full comment: D373378

09013990 9A Watermelon 0.200000 1.000 1.000

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 22 of 33 09014000 9A Watermelon, juice 0.200000 1.000 1.000 15004010 15 Wheat, grain 0.020000 1.000 1.000 15004011 15 Wheat, grain-babyfood 0.020000 1.000 1.000 15004020 15 Wheat, flour 0.020000 1.000 1.000 15004021 15 Wheat, flour-babyfood 0.020000 1.000 1.000 15004030 15 Wheat, germ 0.020000 1.000 1.000 15004040 15 Wheat, bran 0.020000 1.000 1.000
15004050 15 Wild rice 0.020000 1.000 1.000
01034060 1CD Yam, true 0.020000 1.000 1.000

01034070 1CD Yam bean 0.020000 1.000 1.000

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 23 of 33 Attachment 2. Input File for the Chronic Dietary Exposure

Estimates.

U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for THIAMETHOXAM 1994-98 data Residue file: C:\Documents and Settings\dmcneill\My Documents\Thiamethoxam_3\060109

2010 T+FHE+Water.R98 Adjust. #2 NOT used Analysis Date 09-28-2010 Residue file dated: 09-28-2010/14:20:28/8 Reference dose (RfD) = 0.012 mg/kg bw/day

Comment:Acute and Chronic RfDs = aPAD and cPAD

-------------------------------------------------------------------------------- Food Crop Residue Adj.Factors Comment EPA Code Grp Food Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 95000010 O Acerola 0.010000 1.000 1.000 FHE 18000020 18 Alfalfa, seed 0.010000 1.000 1.000 FHE

14000030 14 Almond 0.010000 1.000 1.000 D34927

Full comment: D349272 14000031 14 Almond-babyfood 0.010000 1.000 1.000 14000040 14 Almond, oil 0.010000 1.000 1.000 14000041 14 Almond, oil-babyfood 0.010000 1.000 1.000 04010050 4A Amaranth, leafy 4.000000 1.000 1.000 95000060 O Amaranth, grain 0.010000 1.000 1.000 FHE 11000070 11 Apple, fruit with peel 0.060000 1.000 1.000 D28170

Full comment: D281702 & D265079 11000080 11 Apple, peeled fruit 0.060000 1.000 1.000 11000081 11 Apple, peeled fruit-babyfood 0.060000 1.000 1.000 11000090 11 Apple, dried 0.060000 8.000 1.000 11000091 11 Apple, dried-babyfood 0.060000 8.000 1.000 11000100 11 Apple, juice 0.060000 0.750 1.000 11000101 11 Apple, juice-babyfood 0.060000 0.750 1.000 11000110 11 Apple, sauce 0.060000 1.000 1.000 11000111 11 Apple, sauce-babyfood 0.060000 1.000 1.000 12000120 12 Apricot 0.210000 1.000 1.000 W. Cut Full comment: W. Cuthchin 12/10/03 DERs 12000121 12 Apricot-babyfood 0.210000 1.000 1.000 12000130 12 Apricot, dried 0.210000 6.000 1.000 12000140 12 Apricot, juice 0.210000 1.000 1.000 12000141 12 Apricot, juice-babyfood 0.210000 1.000 1.000 01030150 1CD Arrowroot, flour 0.010000 1.000 1.000 FHE 01030151 1CD Arrowroot, flour-babyfood 0.010000 1.000 1.000 FHE 95000160 O Artichoke, globe 0.190000 1.000 1.000 D28170 Full comment: D281702/D325447 01030170 1CD Artichoke, Jerusalem 0.010000 1.000 1.000 FHE 04010180 4A Arugula 4.000000 1.000 1.000 95000190 O Asparagus 0.010000 1.000 1.000 FHE
95000200 O Avocado 0.110000 1.000 1.000 D35744 Full comment: D357449/D357450 09020210 9B Balsam pear 0.200000 1.000 1.000 95000220 O Bamboo, shoots 0.010000 1.000 1.000 FHE

95000230 O Banana 0.010000 1.000 1.000 FHE 95000231 O Banana-babyfood 0.010000 1.000 1.000 FHE 95000240 O Banana, dried 0.010000 1.000 1.000 FHE 95000241 O Banana, dried-babyfood 0.010000 1.000 1.000 FHE 15000250 15 Barley, pearled barley 0.086000 0.300 1.000 D28170 Full comment: D281702/D325447 15000251 15 Barley, pearled barley-babyfood 0.086000 0.300 1.000 15000260 15 Barley, flour 0.086000 0.100 1.000 15000261 15 Barley, flour-babyfood 0.086000 0.100 1.000 15000270 15 Barley, bran 0.086000 0.300 1.000 19010280 19A Basil, fresh leaves 0.010000 1.000 1.000 FHE 19010281 19A Basil, fresh leaves-babyfood 0.010000 1.000 1.000 FHE 19010290 19A Basil, dried leaves 0.010000 1.000 1.000 FHE 19010291 19A Basil, dried leaves-babyfood 0.010000 1.000 1.000 FHE

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 24 of 33 06030300 6C Bean, black, seed 0.010000 1.000 1.000 S,. Ta Full comment: S,. Tayayin, 26 Nov 2002 06020310 6B Bean, broad, succulent 0.010000 1.000 1.000 06030320 6C Bean, broad, seed 0.010000 1.000 1.000 06020330 6B Bean, cowpea, succulent 0.010000 1.000 1.000 06030340 6C Bean, cowpea, seed 0.010000 1.000 1.000 06030350 6C Bean, great northern, seed 0.010000 1.000 1.000 06030360 6C Bean, kidney, seed 0.010000 1.000 1.000 06020370 6B Bean, lima, succulent 0.010000 1.000 1.000 06030380 6C Bean, lima, seed 0.010000 1.000 1.000 06030390 6C Bean, mung, seed 0.010000 1.000 1.000 06030400 6C Bean, navy, seed 0.010000 1.000 1.000 06030410 6C Bean, pink, seed 0.010000 1.000 1.000 06030420 6C Bean, pinto, seed 0.010000 1.000 1.000 06010430 6A Bean, snap, succulent 0.010000 1.000 1.000 06010431 6A Bean, snap, succulent-babyfood 0.010000 1.000 1.000 21000440 M Beef, meat 0.020000 1.000 1.000 21000441 M Beef, meat-babyfood 0.020000 1.000 1.000 21000450 M Beef, meat, dried 0.020000 1.920 1.000 21000460 M Beef, meat byproducts 0.040000 1.000 1.000 Rec. T

Full comment: Rec. Tol. 21000461 M Beef, meat byproducts-babyfood 0.040000 1.000 1.000 21000470 M Beef, fat 0.010000 1.000 1.000 FHE 21000471 M Beef,fat-babyfood 0.010000 1.000 1.000 FHE 21000480 M Beef, kidney 0.040000 1.000 1.000 21000490 M Beef, liver 0.040000 1.000 1.000 21000491 M Beef, liver-babyfood 0.040000 1.000 1.000 01010500 1AB Beet, garden, roots 0.050000 1.000 1.000 01010501 1AB Beet, garden, roots-babyfood 0.050000 1.000 1.000 02000510 2 Beet, garden, tops 0.010000 1.000 1.000 FHE 01010520 1A Beet, sugar 0.050000 1.000 1.000 01010521 1A Beet, sugar-babyfood 0.050000 1.000 1.000 01010530 1A Beet, sugar, molasses 0.050000 1.000 1.000 01010531 1A Beet, sugar, molasses-babyfood 0.050000 1.000 1.000 95000540 O Belgium endive 0.010000 1.000 1.000 FHE 13010550 13A Blackberry 0.120000 1.000 1.000 D28170

Full comment: D281702 13010560 13A Blackberry, juice 0.120000 1.000 1.000 13010561 13A Blackberry, juice-babyfood 0.120000 1.000 1.000 13020570 13B Blueberry 0.300000 1.000 1.000 13020571 13B Blueberry-babyfood 0.300000 1.000 1.000 13010580 13A Boysenberry 0.120000 1.000 1.000
14000590 14 Brazil nut 0.010000 1.000 1.000
95000600 O Breadfruit 0.010000 1.000 1.000 FHE
05010610 5A Broccoli 0.980000 1.000 1.000 D28170

Full comment: D281702 05010611 5A Broccoli-babyfood 0.980000 1.000 1.000 05010620 5A Broccoli, Chinese 0.980000 1.000 1.000
05020630 5B Broccoli raab 0.820000 1.000 1.000 05010640 5A Brussels sprouts 0.980000 1.000 1.000

15000650 15 Buckwheat 0.020000 1.000 1.000 15000660 15 Buckwheat, flour 0.020000 1.000 1.000

01010670 1AB Burdock 0.050000 1.000 1.000

14000680 14 Butternut 0.010000 1.000 1.000 05010690 5A Cabbage 0.980000 1.000 1.000 05020700 5B Cabbage, Chinese, bok choy 0.820000 1.000 1.000 D28170

Full comment: D281702 05010710 5A Cabbage, Chinese, napa 0.980000 1.000 1.000 05010720 5A Cabbage, Chinese, mustard 0.980000 1.000 1.000

95000730 O Cactus 0.010000 1.000 1.000 FHE 95000740 O Canistel 0.400000 1.000 1.000 09010750 9A Cantaloupe 0.200000 1.000 1.000

04020760 4B Cardoon 4.000000 1.000 1.000

95000770 O Carob 0.010000 1.000 1.000 FHE

01010780 1AB Carrot 0.050000 1.000 1.000 01010781 1AB Carrot-babyfood 0.050000 1.000 1.000 01010790 1AB Carrot, juice 0.050000 1.000 1.000

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 25 of 33 09010800 9A Casaba 0.200000 1.000 1.000

14000810 14 Cashew 0.010000 1.000 1.000

01030820 1CD Cassava 0.010000 1.000 1.000 FHE 01030821 1CD Cassava-babyfood 0.010000 1.000 1.000 FHE
05010830 5A Cauliflower 0.980000 1.000 1.000
01010840 1AB Celeriac 0.050000 1.000 1.000 04020850 4B Celery 4.000000 1.000 1.000 04020851 4B Celery-babyfood 4.000000 1.000 1.000 04020860 4B Celery, juice 4.000000 1.000 1.000

04020870 4B Celtuce 4.000000 1.000 1.000 09020880 9B Chayote, fruit 0.200000 1.000 1.000 95000890 O Cherimoya 0.110000 1.000 1.000 12000900 12 Cherry 0.210000 1.000 1.000 12000901 12 Cherry-babyfood 0.210000 1.000 1.000 12000910 12 Cherry, juice 0.210000 1.500 1.000 12000911 12 Cherry, juice-babyfood 0.210000 1.500 1.000

14000920 14 Chestnut 0.010000 1.000 1.000 40000930 P Chicken, meat 0.010000 1.000 1.000 FHE 40000931 P Chicken, meat-babyfood 0.010000 1.000 1.000 FHE 40000940 P Chicken, liver 0.010000 1.000 1.000 FHE 40000950 P Chicken, meat byproducts 0.010000 1.000 1.000 FHE 40000951 P Chicken, meat byproducts-babyfoo 0.010000 1.000 1.000 FHE 40000960 P Chicken, fat 0.010000 1.000 1.000 FHE 40000961 P Chicken, fat-babyfood 0.010000 1.000 1.000 FHE 40000970 P Chicken, skin 0.010000 1.000 1.000 FHE 40000971 P Chicken, skin-babyfood 0.010000 1.000 1.000 FHE 06030980 6C Chickpea, seed 0.010000 1.000 1.000 06030981 6C Chickpea, seed-babyfood 0.010000 1.000 1.000 06030990 6C Chickpea, flour 0.010000 1.000 1.000 01011000 1AB Chicory, roots 0.050000 1.000 1.000 02001010 2 Chicory, tops 0.010000 1.000 1.000 FHE 09021020 9B Chinese waxgourd 0.200000 1.000 1.000
19011030 19A Chive 0.010000 1.000 1.000 FHE 04011040 4A Chrysanthemum, garland 4.000000 1.000 1.000
19021050 19B Cinnamon 0.010000 1.000 1.000 FHE 19021051 19B Cinnamon-babyfood 0.010000 1.000 1.000 FHE
10001060 10 Citrus citron 0.100000 1.000 1.000 10001070 10 Citrus hybrids 0.100000 1.000 1.000 10001080 10 Citrus, oil 0.100000 0.600 1.000 95001090 O Cocoa bean, chocolate 0.010000 1.000 1.000 FHE 95001100 O Cocoa bean, powder 0.010000 1.000 1.000 FHE
95001110 O Coconut, meat 0.010000 1.000 1.000 FHE 95001111 O Coconut- meat-babyfood 0.010000 1.000 1.000 FHE 95001120 O Coconut, dried 0.010000 1.000 1.000 FHE 95001130 O Coconut, milk 0.010000 1.000 1.000 FHE 95001140 O Coconut, oil 0.010000 1.000 1.000 FHE 95001141 O Coconut, oil-babyfood 0.010000 1.000 1.000 FHE 95001150 O Coffee, roasted bean 0.050000 1.000 1.000 95001160 O Coffee, instant 0.050000 1.000 1.000

05021170 5B Collards 0.820000 1.000 1.000 19011180 19A Coriander, leaves 0.010000 1.000 1.000 FHE 19011181 19A Coriander, leaves-babyfood 0.010000 1.000 1.000 FHE 19021190 19B Coriander, seed 0.010000 1.000 1.000 FHE 19021191 19B Coriander, seed-babyfood 0.010000 1.000 1.000 FHE 15001200 15 Corn, field, flour 0.020000 1.000 1.000 15001201 15 Corn, field, flour-babyfood 0.020000 1.000 1.000 15001210 15 Corn, field, meal 0.020000 1.000 1.000 15001211 15 Corn, field, meal-babyfood 0.020000 1.000 1.000 15001220 15 Corn, field, bran 0.020000 1.000 1.000 15001230 15 Corn, field, starch 0.020000 1.000 1.000 15001231 15 Corn, field, starch-babyfood 0.020000 1.000 1.000 15001240 15 Corn, field, syrup 0.020000 1.500 1.000 15001241 15 Corn, field, syrup-babyfood 0.020000 1.500 1.000 15001250 15 Corn, field, oil 0.020000 1.000 1.000 15001251 15 Corn, field, oil-babyfood 0.020000 1.000 1.000 15001260 15 Corn, pop 0.020000 1.000 1.000 15001270 15 Corn, sweet 0.020000 1.000 1.000

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 26 of 33 15001271 15 Corn, sweet-babyfood 0.020000 1.000 1.000 95001280 O Cottonseed, oil 0.100000 1.000 1.000 95001281 O Cottonseed, oil-babyfood 0.100000 1.000 1.000 11001290 11 Crabapple 0.060000 1.000 1.000 95001300 O Cranberry 0.020000 1.000 1.000 95001301 O Cranberry-babyfood 0.020000 1.000 1.000 95001310 O Cranberry, dried 0.020000 1.000 1.000 95001320 O Cranberry, juice 0.020000 1.100 1.000 95001321 O Cranberry, juice-babyfood 0.020000 1.100 1.000 04011330 4A Cress, garden 4.000000 1.000 1.000 04011340 4A Cress, upland 4.000000 1.000 1.000

09021350 9B Cucumber 0.200000 1.000 1.000

13021360 13B Currant 0.200000 1.000 1.000 13021370 13B Currant, dried 0.200000 1.000 1.000 04011380 4A Dandelion, leaves 4.000000 1.000 1.000 01031390 1CD Dasheen, corm 0.010000 1.000 1.000 FHE 02001400 2 Dasheen, leaves 0.010000 1.000 1.000 FHE

95001410 O Date 0.010000 1.000 1.000 FHE 13011420 13A Dewberry 0.120000 1.000 1.000 19021430 19B Dill, seed 0.010000 1.000 1.000 FHE
19011440 19A Dillweed 0.010000 1.000 1.000 FHE 70001450 P Egg, whole 0.010000 1.000 1.000 FHE 70001451 P Egg, whole-babyfood 0.010000 1.000 1.000 FHE 70001460 P Egg, white 0.010000 1.000 1.000 FHE 70001461 P Egg, white (solids)-babyfood 0.010000 1.000 1.000 FHE 70001470 P Egg, yolk 0.010000 1.000 1.000 FHE 70001471 P Egg, yolk-babyfood 0.010000 1.000 1.000 FHE 08001480 8 Eggplant 0.080000 1.000 1.000 D28170 Full comment: D281702, tomato 13021490 13B Elderberry 0.200000 1.000 1.000
04011500 4A Endive 4.000000 1.000 1.000 95001510 O Feijoa 0.010000 1.000 1.000 FHE 04021520 4B Fennel, Florence 4.000000 1.000 1.000 95001530 O Fig 0.010000 1.000 1.000 FHE 95001540 O Fig, dried 0.010000 1.000 1.000 FHE
14001550 14 Filbert 0.010000 1.000 1.000 14001560 14 Filbert, oil 0.010000 1.000 1.000
80001570 F Fish-freshwater finfish 0.010000 1.000 1.000 FHE 80001580 F Fish-freshwater finfish, farm ra 0.010000 1.000 1.000 FHE 80001590 F Fish-saltwater finfish, tuna 0.010000 1.000 1.000 FHE 80001600 F Fish-saltwater finfish, other 0.010000 1.000 1.000 FHE 80001610 F Fish-shellfish, crustacean 0.010000 1.000 1.000 FHE 80001620 F Fish-shellfish, mollusc 0.010000 1.000 1.000 FHE 20001630 20 Flaxseed, oil 0.020000 1.000 1.000 Tol.
03001640 3 Garlic 0.010000 1.000 1.000 FHE 03001650 3 Garlic, dried 0.010000 1.000 1.000 FHE 03001651 3 Garlic, dried-babyfood 0.010000 1.000 1.000 FHE 01031660 1CD Ginger 0.010000 1.000 1.000 FHE 01031661 1CD Ginger-babyfood 0.010000 1.000 1.000 FHE 01031670 1CD Ginger, dried 0.010000 1.000 1.000 FHE 01011680 1AB Ginseng, dried 0.050000 1.000 1.000
23001690 M Goat, meat 0.020000 1.000 1.000 23001700 M Goat, meat byproducts 0.040000 1.000 1.000 Rec. T

Full comment: Rec. Tol. 23001710 M Goat, fat 0.005000 1.000 1.000 FHE 23001720 M Goat, kidney 0.040000 1.000 1.000 23001730 M Goat, liver 0.040000 1.000 1.000 13021740 13B Gooseberry 0.200000 1.000 1.000 95001750 O Grape 0.060000 1.000 1.000 D28170
Full comment: D281702 95001760 O Grape, juice 0.060000 1.100 1.000 95001761 O Grape, juice-babyfood 0.060000 1.100 1.000 95001770 O Grape, leaves 0.200000 1.000 1.000 95001780 O Grape, raisin 0.060000 2.300 1.000 D28170

Full comment: D281702 95001790 O Grape, wine and sherry 0.060000 1.000 1.000 10001800 10 Grapefruit 0.070000 1.000 1.000

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 27 of 33 10001810 10 Grapefruit, juice 0.070000 0.600 1.000 06031820 6C Guar, seed 0.010000 1.000 1.000 06031821 6C Guar, seed-babyfood 0.010000 1.000 1.000

95001830 O Guava 0.010000 1.000 1.000 FHE 95001831 O Guava-babyfood 0.010000 1.000 1.000 FHE 19011840 19A Herbs, other 0.010000 1.000 1.000 FHE 19011841 19A Herbs, other-babyfood 0.010000 1.000 1.000 FHE 14001850 14 Hickory nut 0.010000 1.000 1.000 95001860 O Honey 0.010000 1.000 1.000 FHE 95001861 O Honey-babyfood 0.010000 1.000 1.000 FHE 09011870 9A Honeydew melon 0.200000 1.000 1.000 95001880 O Hop 0.100000 1.000 1.000 24001890 M Horse, meat 0.020000 1.000 1.000 01011900 1AB Horseradish 0.050000 1.000 1.000 13021910 13B Huckleberry 0.200000 1.000 1.000
95001920 O Jaboticaba 0.010000 1.000 1.000 FHE
95001930 O Jackfruit 0.010000 1.000 1.000 FHE

05021940 5B Kale 0.820000 1.000 1.000
95001950 O Kiwifruit 0.010000 1.000 1.000 FHE
05011960 5A Kohlrabi 0.980000 1.000 1.000 10001970 10 Kumquat 0.400000 1.000 1.000
03001980 3 Leek 0.010000 1.000 1.000 FHE

10001990 10 Lemon 0.090000 1.000 1.000 10002000 10 Lemon, juice 0.090000 0.600 1.000 10002001 10 Lemon, juice-babyfood 0.090000 0.600 1.000 10002010 10 Lemon, peel 0.090000 1.000 1.000 19012020 19A Lemongrass 0.010000 1.000 1.000 FHE 06032030 6C Lentil, seed 0.010000 1.000 1.000 04012040 4A Lettuce, head 4.000000 1.000 1.000 04012050 4A Lettuce, leaf 4.000000 1.000 1.000
10002060 10 Lime 0.100000 1.000 1.000 10002070 10 Lime, juice 0.100000 0.600 1.000 10002071 10 Lime, juice-babyfood 0.100000 0.600 1.000 13012080 13A Loganberry 0.120000 1.000 1.000 95002090 O Longan 0.010000 1.000 1.000 FHE 11002100 11 Loquat 0.060000 1.000 1.000 95002110 O Lychee 0.010000 1.000 1.000 FHE 95002120 O Lychee, dried 0.010000 1.000 1.000 FHE
14002130 14 Macadamia nut 0.010000 1.000 1.000 95002140 O Mamey apple 0.010000 1.000 1.000 FHE 95002150 O Mango 0.110000 1.000 1.000 D35744 Full comment: D357449, avacado 95002151 O Mango-babyfood 0.110000 1.000 1.000 95002160 O Mango, dried 0.110000 1.000 1.000 95002170 O Mango, juice 0.110000 1.000 1.000 95002171 O Mango, juice-babyfood 0.110000 1.000 1.000 95002180 O Maple, sugar 0.010000 1.000 1.000 FHE 95002190 O Maple syrup 0.010000 1.000 1.000 FHE 19012200 19A Marjoram 0.010000 1.000 1.000 FHE 19012201 19A Marjoram-babyfood 0.010000 1.000 1.000 FHE 28002210 M Meat, game 0.020000 1.000 1.000 27002220 D Milk, fat 0.020000 1.000 1.000 27002221 D Milk, fat - baby food/infant for 0.020000 1.000 1.000 27012230 D Milk, nonfat solids 0.020000 1.000 1.000 27012231 D Milk, nonfat solids-baby food/in 0.020000 1.000 1.000 27022240 D Milk, water 0.020000 1.000 1.000 27022241 D Milk, water-babyfood/infant form 0.020000 1.000 1.000 27032251 D Milk, sugar (lactose)-baby food/ 0.020000 1.000 1.000 15002260 15 Millet, grain 0.020000 1.000 1.000 95002270 O Mulberry 0.010000 1.000 1.000 FHE

95002280 O Mushroom 0.010000 1.000 1.000 FHE 05022290 5B Mustard greens 0.820000 1.000 1.000
12002300 12 Nectarine 0.210000 1.000 1.000 15002310 15 Oat, bran 0.020000 1.000 1.000 15002320 15 Oat, flour 0.020000 1.000 1.000 15002321 15 Oat, flour-babyfood 0.020000 1.000 1.000 15002330 15 Oat, groats/rolled oats 0.020000 1.000 1.000

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 28 of 33 15002331 15 Oat, groats/rolled oats-babyfood 0.020000 1.000 1.000

08002340 8 Okra 0.080000 1.000 1.000
95002350 O Olive 0.010000 1.000 1.000 FHE 95002360 O Olive, oil 0.010000 1.000 1.000 FHE 03002370 3 Onion, dry bulb 0.030000 1.000 1.000 03002371 3 Onion, dry bulb-babyfood 0.030000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0.030000 9.000 1.000 03002381 3 Onion, dry bulb, dried-babyfood 0.030000 9.000 1.000 03002390 3 Onion, green 0.010000 1.000 1.000 FHE 10002400 10 Orange 0.100000 1.000 1.000 10002410 10 Orange, juice 0.100000 0.600 1.000 10002411 10 Orange, juice-babyfood 0.100000 0.600 1.000 10002420 10 Orange, peel 0.100000 1.000 1.000 95002430 O Palm heart, leaves 0.010000 1.000 1.000 FHE 95002440 O Palm, oil 0.010000 1.000 1.000 FHE 95002441 O Palm, oil-babyfood 0.010000 1.000 1.000 FHE 95002450 O Papaya 0.110000 1.000 1.000 95002451 O Papaya-babyfood 0.110000 1.000 1.000 95002460 O Papaya, dried 0.110000 1.800 1.000 95002470 O Papaya, juice 0.110000 1.500 1.000 04012480 4A Parsley, leaves 4.000000 1.000 1.000 19012490 19A Parsley, dried leaves 0.010000 1.000 1.000 FHE 19012491 19A Parsley, dried leaves-babyfood 0.010000 1.000 1.000 FHE 01012500 1AB Parsley, turnip rooted 0.050000 1.000 1.000 01012510 1AB Parsnip 0.050000 1.000 1.000 01012511 1AB Parsnip-babyfood 0.050000 1.000 1.000
95002520 O Passionfruit 0.010000 1.000 1.000 FHE 95002521 O Passionfruit-babyfood 0.010000 1.000 1.000 FHE 95002530 O Passionfruit, juice 0.010000 1.000 1.000 FHE 95002531 O Passionfruit, juice-babyfood 0.010000 1.000 1.000 FHE 95002540 O Pawpaw 0.010000 1.000 1.000 FHE 06022550 6B Pea, succulent 0.010000 1.000 1.000 06022551 6B Pea, succulent-babyfood 0.010000 1.000 1.000 06032560 6C Pea, dry 0.010000 1.000 1.000 06032561 6C Pea, dry-babyfood 0.010000 1.000 1.000 06012570 6A Pea, edible podded, succulent 0.010000 1.000 1.000 06032580 6C Pea, pigeon, seed 0.010000 1.000 1.000 06022590 6B Pea, pigeon, succulent 0.010000 1.000 1.000

12002600 12 Peach 0.070000 1.000 1.000 12002601 12 Peach-babyfood 0.070000 1.000 1.000 12002610 12 Peach, dried 0.070000 7.000 1.000 12002611 12 Peach, dried-babyfood 0.070000 7.000 1.000 12002620 12 Peach, juice 0.070000 1.000 1.000 12002621 12 Peach, juice-babyfood 0.070000 1.000 1.000

95002630 O Peanut 0.050000 1.000 1.000 New To
Full comment: New Tol. 95002640 O Peanut, butter 0.050000 1.000 1.000 95002650 O Peanut, oil 0.050000 0.310 1.000

11002660 11 Pear 0.060000 1.000 1.000 11002661 11 Pear-babyfood 0.060000 1.000 1.000 11002670 11 Pear, dried 0.060000 6.250 1.000 11002680 11 Pear, juice 0.060000 0.750 1.000 11002681 11 Pear, juice-babyfood 0.060000 0.750 1.000

14002690 14 Pecan 0.010000 1.000 1.000 08002700 8 Pepper, bell 0.080000 1.000 1.000 D28170 Full comment: D281702, pepper 08002701 8 Pepper, bell-babyfood 0.080000 1.000 1.000 08002710 8 Pepper, bell, dried 0.080000 1.000 1.000 08002711 8 Pepper, bell, dried-babyfood 0.080000 1.000 1.000 08002720 8 Pepper, nonbell 0.080000 1.000 1.000 08002721 8 Pepper, nonbell-babyfood 0.080000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.080000 1.000 1.000 19022740 19B Pepper, black and white 0.010000 1.000 1.000 FHE 19022741 19B Pepper, black and white-babyfood 0.010000 1.000 1.000 FHE 95002750 O Peppermint 1.500000 1.000 1.000 95002760 O Peppermint, oil 1.500000 0.050 1.000
95002770 O Persimmon 0.010000 1.000 1.000 FHE

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 29 of 33 95002780 O Pine nut 0.010000 1.000 1.000 FHE 95002790 O Pineapple 0.010000 1.000 1.000 FHE 95002791 O Pineapple-babyfood 0.010000 1.000 1.000 FHE 95002800 O Pineapple, dried 0.010000 1.000 1.000 FHE 95002810 O Pineapple, juice 0.010000 1.000 1.000 FHE 95002811 O Pineapple, juice-babyfood 0.010000 1.000 1.000 FHE
14002820 14 Pistachio 0.010000 1.000 1.000
95002830 O Plantain 0.010000 1.000 1.000 FHE 95002840 O Plantain, dried 0.010000 1.000 1.000 FHE

12002850 12 Plum 0.071000 1.000 1.000 12002851 12 Plum-babyfood 0.071000 1.000 1.000 12002860 12 Plum, prune, fresh 0.071000 1.000 1.000 12002861 12 Plum, prune, fresh-babyfood 0.071000 1.000 1.000 12002870 12 Plum, prune, dried 0.071000 5.000 1.000 12002871 12 Plum, prune, dried-babyfood 0.071000 5.000 1.000 12002880 12 Plum, prune, juice 0.071000 1.400 1.000 12002881 12 Plum, prune, juice-babyfood 0.071000 1.400 1.000 95002890 O Pomegranate 0.010000 1.000 1.000 FHE 25002900 M Pork, meat 0.020000 1.000 1.000 25002901 M Pork, meat-babyfood 0.020000 1.000 1.000 25002910 M Pork, skin 0.010000 1.000 1.000 FHE 25002920 M Pork, meat byproducts 0.020000 1.000 1.000 25002921 M Pork, meat byproducts-babyfood 0.020000 1.000 1.000 25002930 M Pork, fat 0.010000 1.000 1.000 FHE 25002931 M Pork, fat-babyfood 0.010000 1.000 1.000 FHE 25002940 M Pork, kidney 0.020000 1.000 1.000 25002950 M Pork, liver 0.020000 1.000 1.000 01032960 1C Potato, chips 0.250000 1.200 1.000 01032970 1C Potato, dry (granules/ flakes) 0.250000 1.700 1.000 01032971 1C Potato, dry (granules/ flakes)-b 0.250000 1.700 1.000
01032980 1C Potato, flour 0.250000 1.700 1.000 01032981 1C Potato, flour-babyfood 0.250000 1.700 1.000 01032990 1C Potato, tuber, w/peel 0.250000 1.000 1.000 01032991 1C Potato, tuber, w/peel-babyfood 0.250000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 0.250000 1.000 1.000 01033001 1C Potato, tuber, w/o peel-babyfood 0.250000 1.000 1.000 60003010 P Poultry, other, meat 0.010000 1.000 1.000 FHE 60003020 P Poultry, other, liver 0.010000 1.000 1.000 FHE 60003030 P Poultry, other, meat byproducts 0.010000 1.000 1.000 FHE 60003040 P Poultry, other, fat 0.010000 1.000 1.000 FHE 60003050 P Poultry, other, skin 0.010000 1.000 1.000 FHE 95003060 O Psyllium, seed 0.010000 1.000 1.000 FHE

10003070 10 Pummelo 0.100000 1.000 1.000 09023080 9B Pumpkin 0.200000 1.000 1.000 09023090 9B Pumpkin, seed 0.200000 1.000 1.000 11003100 11 Quince 0.060000 1.000 1.000 95003110 O Quinoa, grain 0.010000 1.000 1.000 FHE 29003120 M Rabbit, meat 0.020000 1.000 1.000
04013130 4A Radicchio 4.000000 1.000 1.000 01013140 1AB Radish, roots 0.050000 1.000 1.000 02003150 2 Radish, tops 0.010000 1.000 1.000 FHE 01013160 1AB Radish, Oriental, roots 0.050000 1.000 1.000 02003170 2 Radish, Oriental, tops 0.010000 1.000 1.000 FHE 05023180 5B Rape greens 0.820000 1.000 1.000 20003190 20 Rapeseed, oil 0.020000 1.000 1.000 20003191 20 Rapeseed, oil-babyfood 0.020000 1.000 1.000 13013200 13A Raspberry 0.120000 1.000 1.000 13013201 13A Raspberry-babyfood 0.120000 1.000 1.000 13013210 13A Raspberry, juice 0.120000 1.000 1.000 13013211 13A Raspberry, juice-babyfood 0.120000 1.000 1.000

04023220 4B Rhubarb 4.000000 1.000 1.000 15003230 15 Rice, white 0.010000 1.000 1.000 15003231 15 Rice, white-babyfood 0.010000 1.000 1.000 15003240 15 Rice, brown 0.010000 1.000 1.000 15003241 15 Rice, brown-babyfood 0.010000 1.000 1.000 15003250 15 Rice, flour 0.010000 1.000 1.000 15003251 15 Rice, flour-babyfood 0.010000 1.000 1.000

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 30 of 33 15003260 15 Rice, bran 0.010000 0.900 1.000 15003261 15 Rice, bran-babyfood 0.010000 0.900 1.000 01013270 1AB Rutabaga 0.050000 1.000 1.000 15003280 15 Rye, grain 0.020000 1.000 1.000 15003290 15 Rye, flour 0.020000 1.000 1.000 20003300 20 Safflower, oil 0.020000 1.000 1.000 20003301 20 Safflower, oil-babyfood 0.020000 1.000 1.000 01013310 1AB Salsify, roots 0.050000 1.000 1.000 02003320 2 Salsify, tops 0.010000 1.000 1.000 FHE 95003330 O Sapote, Mamey 0.400000 1.000 1.000 19013340 19A Savory 0.010000 1.000 1.000 FHE
95003350 O Seaweed 0.010000 1.000 1.000 FHE 95003351 O Seaweed-babyfood 0.010000 1.000 1.000 FHE 95003360 O Sesame, seed 0.010000 1.000 1.000 FHE 95003361 O Sesame, seed-babyfood 0.010000 1.000 1.000 FHE 95003370 O Sesame, oil 0.010000 1.000 1.000 FHE 95003371 O Sesame, oil-babyfood 0.010000 1.000 1.000 FHE

03003380 3 Shallot 0.010000 1.000 1.000 FHE 26003390 M Sheep, meat 0.020000 1.000 1.000 26003391 M Sheep, meat-babyfood 0.020000 1.000 1.000 26003400 M Sheep, meat byproducts 0.040000 1.000 1.000 26003410 M Sheep, fat 0.010000 1.000 1.000 FHE 26003411 M Sheep, fat-babyfood 0.010000 1.000 1.000 FHE 26003420 M Sheep, kidney 0.040000 1.000 1.000 26003430 M Sheep, liver 0.040000 1.000 1.000 15003440 15 Sorghum, grain 0.020000 1.000 1.000 15003450 15 Sorghum, syrup 0.020000 1.000 1.000 95003460 O Soursop 0.010000 1.000 1.000 FHE 06003470 6 Soybean, seed 0.010000 1.000 1.000 D28170

Full comment: D281702 06003480 6 Soybean, flour 0.010000 1.000 1.000 06003481 6 Soybean, flour-babyfood 0.010000 1.000 1.000 06003490 6 Soybean, soy milk 0.010000 1.000 1.000 06003491 6 Soybean, soy milk-babyfood or in 0.010000 1.000 1.000 06003500 6 Soybean, oil 0.010000 1.000 1.000 06003501 6 Soybean, oil-babyfood 0.010000 1.000 1.000 95003510 O Spanish lime 0.010000 1.000 1.000 FHE 95003520 O Spearmint 1.500000 1.000 1.000 95003530 O Spearmint, oil 1.500000 0.050 1.000 D28170

Full comment: D281702 19023540 19B Spices, other 0.010000 1.000 1.000 FHE 19023541 19B Spices, other-babyfood 0.010000 1.000 1.000 FHE 04013550 4A Spinach 4.000000 1.000 1.000 04013551 4A Spinach-babyfood 4.000000 1.000 1.000 09023560 9B Squash, summer 0.200000 1.000 1.000 09023561 9B Squash, summer-babyfood 0.200000 1.000 1.000 09023570 9B Squash, winter 0.200000 1.000 1.000 09023571 9B Squash, winter-babyfood 0.200000 1.000 1.000
95003580 O Starfruit 0.010000 1.000 1.000 FHE 95003590 O Strawberry 0.300000 1.000 1.000 95003591 O Strawberry-babyfood 0.300000 1.000 1.000 95003600 O Strawberry, juice 0.300000 1.000 1.000 95003601 O Strawberry, juice-babyfood 0.300000 1.000 1.000 95003610 O Sugar apple 0.010000 1.000 1.000 FHE 95003620 O Sugarcane, sugar 0.010000 1.000 1.000 FHE 95003621 O Sugarcane, sugar-babyfood 0.010000 1.000 1.000 FHE 95003630 O Sugarcane, molasses 0.010000 1.000 1.000 FHE 95003631 O Sugarcane, molasses-babyfood 0.010000 1.000 1.000 FHE 20003640 20 Sunflower, seed 0.020000 1.000 1.000 20003650 20 Sunflower, oil 0.020000 1.000 1.000 20003651 20 Sunflower, oil-babyfood 0.020000 1.000 1.000 01033660 1CD Sweet potato 0.020000 1.000 1.000 01033661 1CD Sweet potato-babyfood 0.020000 1.000 1.000
04023670 4B Swiss chard 4.000000 1.000 1.000
95003680 O Tamarind 0.010000 1.000 1.000 FHE 10003690 10 Tangerine 0.100000 1.000 1.000 10003700 10 Tangerine, juice 0.100000 0.600 1.000

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 31 of 33 01033710 1CD Tanier, corm 0.020000 1.000 1.000 95003720 O Tea, dried 0.010000 1.000 1.000 FHE 95003730 O Tea, instant 0.010000 1.000 1.000 FHE
08003740 8 Tomatillo 0.080000 1.000 1.000

08003750 8 Tomato 0.080000 1.000 1.000 08003751 8 Tomato-babyfood 0.080000 1.000 1.000 08003760 8 Tomato, paste 0.080000 3.800 1.000 D26507
Full comment: D265079 08003761 8 Tomato, paste-babyfood 0.080000 3.800 1.000 08003770 8 Tomato, puree 0.080000 1.700 1.000 D26507
Full comment: D265079 08003771 8 Tomato, puree-babyfood 0.080000 1.700 1.000 08003780 8 Tomato, dried 0.080000 14.300 1.000 08003781 8 Tomato, dried-babyfood 0.080000 14.300 1.000 08003790 8 Tomato, juice 0.080000 1.500 1.000
95003800 O Tomato, Tree 0.010000 1.000 1.000 FHE 15003810 15 Triticale, flour 0.020000 1.000 1.000 15003811 15 Triticale, flour-babyfood 0.020000 1.000 1.000 50003820 P Turkey, meat 0.010000 1.000 1.000 FHE 50003821 P Turkey, meat-babyfood 0.010000 1.000 1.000 FHE 50003830 P Turkey, liver 0.010000 1.000 1.000 FHE 50003831 P Turkey, liver-babyfood 0.010000 1.000 1.000 FHE 50003840 P Turkey, meat byproducts 0.010000 1.000 1.000 FHE 50003841 P Turkey, meat byproducts-babyfood 0.010000 1.000 1.000 FHE 50003850 P Turkey, fat 0.010000 1.000 1.000 FHE 50003851 P Turkey, fat-babyfood 0.010000 1.000 1.000 FHE 50003860 P Turkey, skin 0.010000 1.000 1.000 FHE 50003861 P Turkey, skin-babyfood 0.010000 1.000 1.000 FHE
01033870 1CD Turmeric 0.250000 1.000 1.000 01013880 1AB Turnip, roots 0.050000 1.000 1.000 05023890 5B Turnip, greens 0.820000 1.000 1.000 95003900 O Vinegar 0.010000 1.000 1.000 FHE

14003910 14 Walnut 0.010000 1.000 1.000 86010000 O Water, direct, all sources 0.011310 1.000 1.000 86020000 O Water, indirect, all sources 0.011310 1.000 1.000

09013990 9A Watermelon 0.200000 1.000 1.000 09014000 9A Watermelon, juice 0.200000 1.000 1.000 15004010 15 Wheat, grain 0.020000 1.000 1.000 15004011 15 Wheat, grain-babyfood 0.020000 1.000 1.000 15004020 15 Wheat, flour 0.020000 1.000 1.000 15004021 15 Wheat, flour-babyfood 0.020000 1.000 1.000 15004030 15 Wheat, germ 0.020000 1.000 1.000 15004040 15 Wheat, bran 0.020000 1.000 1.000
15004050 15 Wild rice 0.020000 1.000 1.000
01034060 1CD Yam, true 0.250000 1.000 1.000
01034070 1CD Yam bean 0.250000 1.000 1.000

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 32 of 33 Attachment 3. Summary of the acute dietary exposure analysis

for thiamethoxam.

U.S. Environmental Protection Agency Ver. 2.02 DEEM-FCID ACUTE Analysis for THIAMETHOXAM (1994-98 data) Residue file: 060109 2010 Acute T+Water.R98 Adjustment factor #2 NOT used. Analysis Date: 09-28-2010/14:24:08 Residue file dated: 09-28-2010/14:19:26/8 Daily totals for food and foodform consumption used.
Run Comment: "Acute and Chronic RfDs = aPAD and cPAD"

===============================================================================

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- U.S. Population:

0.018094 5.17 0.029790 8.51 0.058415 16.69 All infants:

0.033165 9.48 0.053499 15.29 0.087409 24.97 Children 1-2 yrs:

0.032947 9.41 0.056186 16.05 0.108420 30.98 Children 3-5 yrs:

0.026627 7.61 0.046231 13.21 0.079162 22.62 Children 6-12 yrs:

0.018819 5.38 0.034746 9.93 0.071004 20.29 Youth 13-19 yrs:

0.014311 4.09 0.022203 6.34 0.038760 11.07 Adults 20-49 yrs:

0.016277 4.65 0.025243 7.21 0.042160 12.05 Adults 50+ yrs:

0.016617 4.75 0.025593 7.31 0.040500 11.57 Females 13-49 yrs:

0.016123 4.61 0.025604 7.32 0.046388 13.25

### Thiamethoxam (060109) Dietary Exposure and Risk Assessment DP Number 376368



## Page 33 of 33 Attachment 4. Summary of the chronic dietary exposure analysis

for thiamethoxam.

U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for THIAMETHOXAM (1994-98 data) Residue file name: C:\Documents and Settings\dmcneill\My Documents\Thiamethoxam_3\060109 2010

T+FHE+Water.R98 Adjustment factor #2 NOT used. Analysis Date 09-28-2010/14:21:15 Residue file dated: 09-28-2010/14:20:28/8 Reference dose (RfD, Chronic) = .012 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.002825 23.5%

U.S. Population (spring season) 0.002894 24.1% U.S. Population (summer season) 0.002814 23.5% U.S. Population (autumn season) 0.002786 23.2% U.S. Population (winter season) 0.002809 23.4%

Northeast region 0.002932 24.4% Midwest region 0.002844 23.7% Southern region 0.002543 21.2% Western region 0.003155 26.3%

Hispanics 0.002912 24.3% Non-hispanic whites 0.002826 23.5% Non-hispanic blacks 0.002448 20.4% Non-hisp/non-white/non-black 0.003674 30.6%

All infants (< 1 year) 0.003052 25.4% Nursing infants 0.001338 11.2% Non-nursing infants 0.003703 30.9% Children 1-6 yrs 0.004617 38.5% Children 7-12 yrs 0.003133 26.1%

Females 13-19 (not preg or nursing) 0.002248 18.7% Females 20+ (not preg or nursing) 0.002722 22.7% Females 13-50 yrs 0.002669 22.2% Females 13+ (preg/not nursing) 0.002473 20.6% Females 13+ (nursing) 0.003126 26.1%

Males 13-19 yrs 0.002398 20.0% Males 20+ yrs 0.002493 20.8%
Seniors 55+ 0.002624 21.9%

Children 1-2 yrs 0.005150 42.9% Children 3-5 yrs 0.004520 37.7% Children 6-12 yrs 0.003241 27.0% Youth 13-19 yrs 0.002333 19.4% Adults 20-49 yrs 0.002591 21.6% Adults 50+ yrs 0.002648 22.1% Females 13-49 yrs 0.002617 21.8%

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