<PAGE>
 
                              SECURITY AGREEMENT


          THIS SECURITY AGREEMENT dated as of December 6, 1996 executed and
delivered by ZYNAXIS VACCINE TECHNOLOGIES, INC., a corporation organized under
the laws of Pennsylvania, with its principal place of business and chief
executive office located at 371 Phoenixville Pike, Malvern, Chester County,
Pennsylvania (the "Debtor"), in favor of CYTRX CORPORATION, with an office
located at 154 Technology Parkway, Norcross, Georgia 30092 (the "Secured
Party").

          WHEREAS, the Debtor has executed and delivered that certain Guaranty
dated the date hereof (the "Guaranty") guaranteeing the obligations of Zynaxis,
Inc., Debtor's parent ("Zynaxis"), to the Secured Party and desires to secure
its obligations under the Guaranty by granting to the Secured Party a security
interest in certain of the Debtor's assets;

          NOW, THEREFORE, in consideration of the above premises and for other
good and valuable consideration, the receipt and sufficiency of which are hereby
acknowledged by the Debtor, the Debtor hereby agrees with the Secured Party as
follows:

          Section 1.  Grant of Security.  To secure the prompt and complete
                      -----------------                                    
payment, observance and performance when due (whether at stated maturity, by
acceleration or otherwise) of all of the Guaranteed Obligations, the Debtor
hereby collaterally assigns and pledges to the Secured Party, and grants to the
Secured Party a security interest in, the Collateral.

          Section 2.  Representations and Warranties.  The Debtor represents 
                      ------------------------------      
and warrants to the Secured Party as follows:

          (a) Name.  The correct corporate name of the Debtor is set forth in
              ----                                                           
the first paragraph of this Agreement, and the Debtor does not conduct and,
during the five-year period immediately preceding the date of this Agreement,
has not conducted, business under any trade name or other fictitious name other
than those set forth in Schedule (a) attached hereto.

          (b) Organization; Power; Qualification.  The Debtor is a corporation,
              ----------------------------------                               
duly organized, validly existing and in good standing under the laws of the
Commonwealth of Pennsylvania, and has the corporate power and authority to carry
on its business as now conducted and to own, lease and operate its material
Assets.  The Debtor is duly qualified or licensed to transact business as a
foreign corporation in good standing in the States of the United States and
foreign jurisdictions where the character of its Assets or the nature or conduct
of its business requires it to be so qualified or licensed, except for such
jurisdictions in which the failure to be so qualified or licensed is not
reasonably likely to have, individually or in the aggregate, a Material Adverse
Effect on the Debtor.
<PAGE>
 
          (c) Authorization.  The Debtor has the right and power, and has taken
              -------------                                                    
all necessary action to authorize it to execute, deliver and perform this
Agreement in accordance with its terms.  This Agreement, the Financing
Statements and the instruments, agreements and other documents to which the
Debtor is a party and which evidence or relate in any way to the Guaranteed
Obligations have been executed and delivered by the authorized officers of the
Debtor and each is a legal, valid and binding obligation of the Debtor
enforceable against the Debtor in accordance with its terms.

          (d) Compliance of Agreement with Laws, etc.  Subject to execution of
              --------------------------------------                          
that certain Preferred Stock and Warrant Agreement by and among Zynaxis, the
Secured Party, Vaxcel, Inc., and the holders of the outstanding shares of the
Debtor's Series A Convertible Preferred Stock, the execution, delivery and
performance of this Agreement by the Debtor in accordance with its terms,
including the granting of the Security Interest, do not and will not, by the
passage of time, the giving of notice or otherwise (i) conflict with, result in
a breach of or constitute a default under any indenture, instrument or other
agreement to which the Debtor is a party or by which it or any of its properties
may be bound or (ii) result in, or require the creation or imposition of, any
Lien upon or with respect to any property in which the Debtor now or may
hereafter have rights.

          (e) Liens.  None of the Collateral is, as of the date hereof, 
              -----   
subject to any Lien, except Permitted Liens set forth in Schedule (e). No
financing statement under the Uniform Commercial Code of any jurisdiction which
names the Debtor as debtor or covers any of the Collateral, or any other notice
filed in the public records indicating the existence of a Lien thereon, has been
filed and is still effective in any jurisdiction, and the Debtor has not signed
any such financing statement or notice or any security agreement authorizing any
Person to file any such financing statement or notice.

          (f) Chief Executive Office.  The chief executive office and principal 
              ----------------------   
place of business of the Debtor are located at the address set forth in the
first paragraph of this Agreement, and have been located there for the five-year
period immediately preceding the date hereof. Except as listed in Schedule
2.(f), during such five-year period the Debtor has not changed its name,
identity or corporate structure in any way.

          (g) Places of Business.  The addresses (including the applicable 
              ------------------   
counties) of all of the places of business of the Debtor are set forth in
Schedule (g) attached hereto.

          (h) Collateral.  All Equipment of the Debtor is located on or at one 
              ----------       
or more of the places set forth in Schedule (h) hereof.

          (i) Security Interest.  It is the intent of the Debtor that this 
              -----------------   
Agreement create a valid and perfected first-priority security interest in the
Collateral, securing the payment of the Guaranteed Obligations, except with
respect to the Collateral subject to the Permitted Liens set forth in Schedule
(e), with respect to which Collateral the Debtor and the Secured Party hereby
agree and acknowledge that this Agreement shall create a valid and perfected
second-priority security interest therein.
<PAGE>
 
     Section 3.  Continued Priority of Security Interest.
                 --------------------------------------- 

     (a) The Security Interest shall at all times be valid, perfected and of
first priority, except as set forth in Section (i) hereof, and enforceable
against the Debtor and all other Persons, in accordance with the terms of this
Agreement, as security for the Guaranteed Obligations.  The Debtor shall, at its
sole cost and expense, take all action that may be necessary or desirable, or
that the Secured Party may request, so as at all times to maintain the validity,
perfection, enforceability and priority of the Security Interest in the
Collateral in conformity with the immediately preceding sentence, or to enable
the Secured Party to exercise or enforce its rights hereunder, including, but
not limited to, executing and delivering financing statements, pledges,
designations, hypothecations, notices and assignments, in each case in form and
substance satisfactory to the Secured Party, relating to the creation, validity,
perfection, priority or continuation of the Security Interest under the Uniform
Commercial Code or other Applicable Law.

     (b) The Secured Party is hereby authorized to execute and file in all
necessary and appropriate jurisdictions (as determined by the Secured Party) one
or more financing statements (or any other document or instrument referred to in
this Section) in the name of the Debtor and to sign the Debtor's name thereto.
The Debtor authorizes the Secured Party to file any such financing statement,
document or instrument without the signature of the Debtor to the extent
permitted by Applicable Law.  Further, to the extent permitted by Applicable
Law, a carbon, photographic, xerographic or other reproduction of this Agreement
or of any Financing Statement is sufficient as a financing statement.

     Section 4.  Covenants Regarding Collateral Generally.
                 ---------------------------------------- 

     (a) Delivery of Instruments.  In the event any of the Collateral becomes
         -----------------------                                             
evidenced by an instrument, the Debtor will immediately thereafter deliver such
instrument to the Secured Party, appropriately endorsed to the Secured Party.

     (b) Defense of Title.  The Debtor shall at all times be the sole owner of
         ----------------                                                     
each and every item of Collateral and shall defend its title in and to, and the
Secured Party's Security Interest in, the Collateral against the claims and
demands of all Persons.

     (c) Maintenance of Collateral.  The Debtor shall maintain all physical
         -------------------------                                         
property that constitutes Collateral in good and workable condition, with
reasonable allowance for wear and tear, and shall exercise proper custody over
all such property.

     (d) Insurance.  Zynaxis, on behalf of the Debtor, shall at all times
         ---------                                                       
maintain insurance on the Collateral against loss or damage by fire, theft,
burglary, pilferage, loss in transit and such other hazards and risks as the
Secured Party shall specify, in amounts (which shall not be less than the
aggregate value of the Collateral) and under policies issued by insurers
acceptable to the Secured Party.  All premiums on such insurance shall be paid
by Zynaxis, on behalf of the Debtor, and certified copies of the policies, or
<PAGE>
 
other evidence of insurance acceptable to the Secured Party, shall be delivered
to the Secured Party promptly upon the Secured Party's request.  The Debtor will
not use or permit the Collateral to be used unlawfully or outside of any
insurance coverage.  All insurance policies required under this Section shall
contain loss payable clauses on New York standard loss payee forms or other
forms satisfactory to the Secured Party, naming the Secured Party as loss payee,
and providing that no such insurance shall be affected by any act or neglect of
the insured or owner of the property described in such policy and such policies
and loss payable clauses may not be canceled, amended or terminated with respect
to the Secured Party unless at least thirty days' prior written notice is given
to the Secured Party.

     (e) Location of Office.  The Debtor's chief executive office, principal
         ------------------                                                 
place of business will continue to be kept at the address set forth in the first
paragraph of this Agreement and the Debtor will not change the location of such
office and place of business or such books and records without giving the
Secured Party at least thirty days' prior written notice thereof.

     (f) Location of Collateral.  All Equipment and all other tangible
         ----------------------                                       
Collateral will at all times be kept by the Debtor at the locations set forth in
Schedule (f), and shall not, without the prior written consent of the Secured
Party, be removed therefrom except in connection with sales thereof made in the
ordinary course of business or pursuant to the Liquidation Agreement.

     (g) Inspection.  The Secured Party (by any of its officers, employees or
         ----------                                                          
agents) shall have the right, at any time or times during normal business hours:
(i) to inspect the Collateral, all files relating thereto and the premises upon
which any of the Collateral is located, (ii) to discuss the Debtor's affairs and
finances with any Person, to verify the amount, quantity, value and condition
of, or any other matter relating to, any of the Collateral and (iii) to review,
audit and make extracts from all records and files related to any of the
Collateral.

     (h) Other Information.  The Debtor shall furnish to the Secured Party such
         -----------------                                                     
other information with respect to the Collateral as the Secured Party may
reasonably request from time to time.

     (i) Payments Directly to Secured Party.  The Secured Party may at any time
         ----------------------------------                                    
and from time to time after the occurrence of an Event of Default notify, or
request the Debtor to notify, in writing or otherwise, any account debtor or
other obligor with respect to any one or more of the Receivables to make payment
to the Secured Party or any agent or designee of the Secured Party directly, at
such address as may be specified by the Secured Party.  If, notwithstanding the
giving of any notice, any account debtor or other such obligor shall make
payment to the Debtor, the Debtor shall hold all such payments it receives in
trust for the Secured Party, without commingling the same with other funds or
property of or held by the Debtor, and shall promptly deliver the same to the
Secured Party or any such agent or designee immediately upon receipt by the
Debtor in the identical form received, together with any necessary endorsements.
<PAGE>
 
     (j) Proceeds of Collateral.  The Debtor shall account fully and faithfully
         ----------------------                                                
for proceeds in whatever form received in disposition in any manner of any of
the Collateral.  To the extent practicable, the Debtor shall at all times keep
accurate and complete records of the Collateral and proceeds thereof.

     Section 5.  Debtor's Name.  So long as any of the Guaranteed Obligations
                 -------------                                               
remain unpaid or unperformed, the Debtor shall not, without giving the Secured
Party at least sixty days' prior written notice, (i) change its name, identity
or structure or (ii) conduct business under any trade name or other fictitious
name other than those set forth in Schedule (a).

     Section 6.  The Secured Party Appointed Attorney-in-Fact.  The Debtor
                 --------------------------------------------             
hereby irrevocably appoints the Secured Party the Debtor's attorney-in-fact,
effective after the occurrence of an Event of Default and for so long thereafter
as there are unsatisfied Guaranteed Obligations, with full authority in the
place and stead of the Debtor and in the name of the Debtor or otherwise, from
time to time in the Secured Party's discretion to take any action and to execute
any instrument or document which the Secured Party may deem necessary or
advisable to accomplish the purposes of this Agreement and to exercise any
rights and remedies the Secured Party may have under this Agreement or
Applicable Law, including, without limitation: (i) to obtain and adjust
insurance required to be maintained pursuant to Section (d) hereof; (ii) to
ask, demand, collect, sue for, recover, compromise, receive and give acquittance
and receipts for moneys due and to become due under or in respect of any of the
Collateral, including any Receivable; (iii) to receive, endorse, and collect any
drafts or other instruments, documents and chattel paper, in connection with
clause (i) or (ii) above; (iv) to sell or assign any Receivable upon such terms,
for such amount and at such time or times as the Secured Party deems advisable,
to settle, adjust, compromise, extend or renew any Receivable or to discharge
and release any Receivable; (v) to file any claims or take any action or
institute any proceedings which the Secured Party may deem necessary or
desirable for the collection of any of the Collateral or otherwise to enforce
the rights of the Secured Party with respect to any of the Collateral; and (vi)
to execute any document or instrument referred to in Section   The power-of-
attorney granted hereby shall be irrevocable and coupled with an interest.

     Section 7.  The Secured Party May Perform.  If the Debtor fails to perform
                 -----------------------------                                 
any agreement contained herein, the Secured Party may, without notice to the
Debtor, itself perform, or cause performance of, such agreement, and the
expenses of the Secured Party incurred in connection therewith shall be payable
by the Debtor under Section  hereof.

     Section 8.  Remedies.  The Secured Party may take any or all of the
                 --------                                               
following actions upon the occurrence of an Event of Default hereunder.
<PAGE>
 
     (a) Acceleration.  Upon the occurrence of an Event of Default specified in
         ------------                                                          
clauses (f) or (g) of the definition thereof, all of the Guaranteed Obligations
shall become automatically due and payable without presentment, demand, protest,
or other notice of any kind, all of which are expressly waived, notwithstanding
anything in this Agreement or any other agreement evidencing any Guaranteed
Obligations to the contrary.  If any other Event of Default shall have occurred
and be continuing, the Secured Party may declare all of the Guaranteed
Obligations to be forthwith due and payable, whereupon the same shall
immediately become due and payable without presentment, demand, protest or other
notice of any kind, all of which are expressly waived, anything in this
Agreement or any other agreement evidencing any Guaranteed Obligations to the
contrary notwithstanding.

     (b)  Equipment.
          --------- 

          (i)  Entry.  The Secured Party may enter upon any premises on which
               -----                                                         
     Equipment may be located and, without resistance or interference by the
     Debtor, take physical possession of any or all thereof and maintain such
     possession on such premises or move the same or any part thereof to such
     other place or places as the Secured Party shall choose, without being
     liable to the Debtor on account of any loss, damage or depreciation that
     may occur as a result thereof, other than for actions that were not taken
     in good faith.

          (ii) Assembly.  The Debtor shall, upon request of and without charge
               --------                                                       
     to the Secured Party, assemble the Equipment and maintain or deliver it
     into the possession of the Secured Party or any agent or representative of
     the Secured Party at such place or places as the Secured Party may
     designate and as are reasonably convenient to both the Secured Party and
     the Debtor.

     (c) Use of Premises.  The Secured Party may without notice, demand or other
         ---------------                                                        
process, and without payment of any rent or any other charge enter any of the
Debtor's premises and, without breach of the peace, until the Secured Party
completes the enforcement of its rights in the Collateral, take possession of
such premises or place custodians in exclusive control thereof, remain on such
premises and use the same and any of the Debtor's equipment, for the purpose of
(A) completing any work in process, preparing any Equipment for disposition and
disposing thereof and (B) collecting any Receivable.

     (d) Rights as a Secured Creditor.  The Secured Party may exercise all of
         ----------------------------                                        
the rights and remedies of a secured party under the Uniform Commercial Code and
under any other Applicable Law, including, without limitation, the right,
without notice except as specified below and with or without taking possession
thereof, to sell the Collateral or any part thereof in one or more parcels at
public or private sale at any location chosen by the Secured Party, for cash, on
credit or for future delivery, and at such price or prices and upon such other
terms as the Secured Party may deem commercially reasonable.  The Debtor agrees
that, to the extent notice of sale shall be required by Applicable Law, at least
ten days' prior notice to the Debtor of the time and place of any public sale or
<PAGE>
 
the time after which any private sale is to be made shall constitute reasonable
notification, but notice given in any other reasonable manner or at any other
reasonable time shall constitute reasonable notification.  The Secured Party
shall not be obligated to make any sale of Collateral regardless of notice of
sale having been given.  The Secured Party may adjourn any public or private
sale from time to time by announcement at the time and place fixed therefor, and
such sale may, without further notice, be made at the time and place to which it
was so adjourned.

     (e) Waiver of Marshaling.  The Debtor hereby waives any right to require
         --------------------                                                
any marshaling of assets and any similar right.

     (f) Appointment of Receiver.  The Secured Party shall be entitled to the
         -----------------------                                             
appointment of a receiver, without notice of any kind whatsoever and without
regard to the adequacy of any security for the Guaranteed Obligations or the
solvency of any party bound for its payment, to take possession of all or any
portion of the Collateral and/or the business operations of the Debtor and to
exercise such power as the court shall confer upon such receiver.

     Section 9.  Application of Proceeds.  All proceeds from each sale of, or
                 -----------------------                                     
other realization upon, all or any part of the Collateral following an Event of
Default shall be applied or paid over as follows:

     (a) First:  to the payment of all costs and expenses incurred in connection
with such sale or other realization, including reasonable attorneys' fees if the
Secured Party endeavored to collect the Guaranteed Obligations by or through an
attorney at law;

     (b) Second:  to the payment of the interest due upon any of the Guaranteed
Obligations, in any order which the Secured Party may elect;

     (c) Third:  to the payment of the principal due upon any of the Guaranteed
Obligations in any order which the Secured Party may elect; and

     (d) Fourth:  the balance (if any) of such proceeds shall be paid to the
Debtor or to whomsoever may be legally entitled thereto.

The Debtor shall remain liable and shall pay, on demand, any deficiency
remaining in respect of the Guaranteed Obligations, together with interest
thereon at a rate per annum equal to the highest rate then payable hereunder on
such Guaranteed Obligations, which interest shall constitute part of the
Guaranteed Obligations.

     Section 10.  Rights Cumulative.  The rights and remedies of the Secured
                  -----------------                                         
Party under this Agreement and each other document or instrument evidencing or
securing the Guaranteed Obligations shall be cumulative and not exclusive of any
rights or remedies which it would otherwise have.  In exercising its rights and
remedies the Secured Party may be selective and no failure or delay by the
Secured Party in exercising any right shall operate as a waiver of it, nor shall
any single or partial exercise of any power or right preclude its other or
further exercise or the exercise of any other power or right.
<PAGE>
 
     Section 11.  Expenses.  Upon the occurrence of an Event of Default, the
                  --------                                                  
Debtor will pay, on demand, all out-of-pocket expenses incurred by the Secured
Party in connection with:  (a) the collection or enforcement of the Guaranteed
Obligations including the reasonable fees and disbursements of counsel to the
Secured Party, if such collection or enforcement is done through or by an
attorney, and (b) the exercise by the Secured Party of any right or remedy
granted to it under this Agreement, including, without limitation, the expenses
incurred by the Secured Party in connection with the collection of Receivables
directly from account debtors.

     Section 12.  Amendments, Etc.  No amendment or waiver of any provision of
                  ----------------                                            
this Agreement nor consent to any departure by the Debtor herefrom shall in any
event be effective unless the same shall be in writing and signed by the parties
hereto, and then such waiver or consent shall be effective only in the specific
instance and for the specific purpose for which given.

     Section 13.  Notices.  Unless otherwise provided herein, communications
                  -------                                                   
provided for hereunder shall be in writing and shall be mailed, whether by
first-class United States Post or by any commercial express mail carrier
(including Federal Express and U.P.S.), telecopied or delivered, if to the
Debtor:  at its address at 371 Phoenixville Pike, Malvern, Pennsylvania 19355,
Attn: Martyn Greenacre, telephone number: (610) 889-2200, telecopy number: (610)
889-2222, with a copy to Morgan, Lewis & Bockius LLP, 2000 One Logan Square,
Philadelphia, Pennsylvania 19103-6993, Attn: David King, telephone number: (215)
963-5000, telecopy number: (215) 963-5299; if to the Secured Party, at its
address at 154 Technology Parkway, Norcross, Georgia 30092, Attn: Jack J.
Luchese, telephone number: (770) 368-9500, telecopy number: (770) 448-3357, with
a copy to Alston & Bird, One Atlantic Center, 1201 West Peachtree Street,
Atlanta, Georgia 30309-3424, Attn: George M. Maxwell, Jr., telephone number:
(404) 881-7000, telecopy number: (404) 881-7777; or, as to each party, at such
other address as shall be designated by such party in a written notice to the
other parties.  All such notices and other communications to the Debtor shall be
effective (i) if mailed, when received or three days after mailing, whichever is
earlier; (ii) if telecopied, when transmitted; or (iii) if hand delivered, when
delivered.  All such notices or communications to the Secured Party shall be
effective when actually received.

     Section 14.  Continuing Security Interest.  This Agreement shall create a
                  ----------------------------                                
continuing security interest in the Collateral and shall (i) remain in full
force and effect until indefeasible payment in full of the Guaranteed
Obligations, (ii) be binding upon the Debtor, its successors and assigns and
(iii) inure to the benefit of the Secured Party, and its successors and assigns.
The Debtor's successors and assigns shall include, without limitation, a
receiver, trustee or debtor-in-possession thereof or therefore.

     Section 15.  Applicable Law; Severability.  THIS AGREEMENT SHALL BE
                  ----------------------------                          
GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF GEORGIA.
Whenever possible, each provision of this Agreement shall be interpreted in such
a manner as to be effective and valid under Applicable Law, but if any provision
of this Agreement shall be prohibited by or invalid under Applicable Law, such
provisions shall be ineffective only to the extent of such prohibition or
invalidity, without invalidating the remainder of such provisions or the
remaining provisions of this Agreement.
<PAGE>
 
     Section 16.  Waiver.  THE DEBTOR WAIVES (i) ANY NOTICE PRIOR TO THE TAKING
                  ------                                                       
POSSESSION OR CONTROL OF THE COLLATERAL OR ANY POSTING OF ANY BOND OR SECURITY
WHICH MIGHT BE REQUIRED BY ANY COURT PRIOR TO ALLOWING THE SECURED PARTY TO
EXERCISE ANY OF SECURED PARTY'S REMEDIES SET FORTH HEREIN, INCLUDING THE
ISSUANCE OF AN IMMEDIATE WRIT OF POSSESSION AND (ii) THE BENEFIT OF ALL
VALUATION, APPRAISEMENT AND EXEMPTION LAWS.

     Section 17.  Indemnification.  The Debtor agrees to indemnify and hold the
                  ---------------                                              
Secured Party harmless from and against any claim, loss, damage, action, cause
of action, liability, cost and expense or suit of any kind or nature whatsoever,
including reasonable attorneys' fees and expenses, brought against or incurred
by the Secured Party, in any manner arising out of or, directly or indirectly,
related to or connected with any action taken by the Secured Party pursuant to
the terms of this Agreement; provided, however, that the indemnity set forth in
this Section 18. shall not apply to the extent that the claim, loss, damage,
action, cause of action, liability, cost, expense or suit arises primarily and
directly from the gross negligence or willful misconduct of the Secured Party.

     Section 19.  Counterparts.  This Agreement may be executed in several
                  ------------                                            
counterparts, each of which shall be an original and all of which, taken
together, shall constitute but one and the same instrument.

     Section 20.  Definitions.  (a) For the purposes of this Agreement:
                  -----------                                          

     "Agreement" means this Security Agreement, as the same may be amended,
      ---------                                                            
supplemented, restated or otherwise modified from time to time.

     "Applicable Law" means all applicable provisions of constitutions,
      --------------                                                   
statutes, laws, rules, regulations and orders of all governmental bodies and all
orders, rulings and decrees of all courts and arbitrators.

     "Assets" of a Person means all of the assets, properties, businesses and
      ------                                                                 
rights of such Person of every kind, nature, character and description, whether
real, personal or mixed, tangible or intangible, accrued or contingent, or
otherwise relating to or utilized in such Person's business, directly or
indirectly, in whole or in part, whether or not carried on the books and records
of such Person, and whether or not owned in the name of such Person or any
Subsidiary of such Person and wherever located.

     "Capitalized Lease Obligation" means Indebtedness represented by
      ----------------------------                                   
obligations under a lease that is required to be capitalized for financial
reporting purposes in accordance with GAAP, and the amount of such Indebtedness
shall be the capitalized amount of such obligations determined in accordance
with such principles.

     "Collateral" means all of the Debtor's right, title and interest in and to
      ----------                                                               
each of the following, wherever located and whether now or hereafter existing,
or now owned or hereafter acquired or arising:
<PAGE>
 
     (a)  all Receivables;

     (b)  all Equipment;

     (c) all rights of the Debtor as an unpaid vendor or lienor (including,
without limitation, stoppage in transit, replevin and reclamation) with respect
to any other properties of the Debtor;

     (d) all general intangibles of the Debtor including, but not limited to,
all contract rights of the Debtor and all trademarks, trade names, patents,
copyrights and any and all other intellectual property of the Debtor, but not
including the intangibles described on Schedule 19.(a);

     (e) all documents of title, policies and certificates of insurance, chattel
paper and instruments of the Debtor;

     (f) all books, records, files and correspondence in any way related to any
of the foregoing or otherwise pertaining to the business operations of the
Debtor;

     (g) any and all balances, credits, deposits, accounts, items and monies of
the Debtor now or hereafter with the Secured Party or any Subsidiary of the
Secured Party or deposited with the Secured Party or any financial institution
selected by the Secured Party pursuant to any lock box, deposit, escrow or other
collection agreement or otherwise, and all property of the Debtor of every kind
and description now or hereafter in the possession or control of the Secured
Party for any reason; and

     (h) any and all products and proceeds of any of the foregoing (including,
but not limited to, any claims to any items referred to in this definition, and
any claims of the Debtor against third parties for loss of, damage to or
destruction of, any or all of the Collateral or for proceeds payable under, or
unearned premiums with respect to, policies of insurance) in whatever form,
including, but not limited to, cash, instruments, general intangibles, accounts
receivable, goods, documents and chattel paper.

     "Debtor" has the meaning set forth in the first paragraph hereof.
      ------                                                          

     "Default" means any of the events specified in the definition of Event of
      -------                                                                 
Default, whether or not there has been satisfied any requirement for giving of
notice, lapse of time or the happening of any other condition.

     "Equipment" means all equipment, machinery, apparatus, fittings, fixtures
      ---------                                                               
and other tangible personal property of every kind and description owned by the
Debtor or in which the Debtor has an interest, and all parts, accessories and
special tools and all increases and accessions thereto and substitutions and
replacements therefor; provided, however, that the term "Equipment" shall not be
deemed to include items leased by the Debtor as lessee.

     "Event of Default" means any of the following events, whatever the reason
      ----------------                                                        
for such event and whether it shall be voluntary or involuntary or be effected
by operation of law or pursuant to any judgment or order of any court or any
order, rule or regulation of any governmental or nongovernmental body:
<PAGE>
 
     (a) failure of the Debtor to pay any principal, interest or other amount
with respect to any of the Guaranteed Obligations when due;

     (b) the failure of the Debtor to comply with any of the terms and
provisions of this Agreement or any of the documents or instruments evidencing
any of the Guaranteed Obligations;

     (c) any written representation or warranty made at any time by the Debtor
to the Secured Party shall prove to have been incorrect or misleading in any
material respect when made;

     (d) a default, event of default, or event which with the giving of notice
or the passage of time or both would constitute a default or event of default,
shall have occurred under any other document, instrument, contract or agreement
now or hereafter entered into by the Debtor and Secured Party or executed by the
Debtor in favor of the Secured Party, or the Debtor shall in any way fail to
comply with the terms, covenants or conditions contained in any such document,
instrument, contract or agreement;

     (e) a default, event of default, or event which with the giving of notice
or the passage of time or both would constitute a default or event of default,
shall have occurred under any document, instrument, contract or agreement (i)
evidencing or securing indebtedness of the Debtor for borrowed money or (ii)
material to the financial condition of the Debtor; provided, however, that the
Debtor's failure to pay royalties as described in letters from Southern Research
Institute to Debtor dated August 21, 1996 and August 27, 1996 shall not
constitute an Event of Default if Zynaxis complies with the covenant in Section
8.10 of the Agreement and Plan of Merger and Contribution dated the date hereof
to which Zynaxis and the Secured Party are parties.

     (f) the Debtor shall (i) commence a voluntary case under the Bankruptcy
Code of 1978, as amended or other federal bankruptcy law (as now or hereafter in
effect); (ii) file a petition seeking to take advantage of any other laws,
domestic or foreign, relating to bankruptcy, insolvency, reorganization, winding
up or composition for adjustment of debts; (iii) consent to, or fail to contest
in a timely and appropriate manner, any petition filed against it in an
involuntary case under such bankruptcy laws or other laws; (iv) apply for or
consent to, or fail to contest in a timely and appropriate manner, the
appointment of, or the taking of possession by, a receiver, custodian, trustee,
or liquidator of itself or of a substantial part of its property, domestic or
foreign; (v) be unable to, or admit in writing its inability to, pay its debts
as they become due; (vi) make a general assignment for the benefit of creditors;
or (vii) make a conveyance fraudulent as to creditors under any state or federal
law; or

     (g) a case or other proceeding shall be commenced against the Debtor in any
court of competent jurisdiction seeking (i) relief under the Bankruptcy Code of
1978, as amended or other federal bankruptcy law (as now or hereafter in effect)
or under any other laws, domestic or foreign, relating to bankruptcy,
insolvency, reorganization, winding up or adjustment of debts or (ii) the
appointment of a trustee, receiver, custodian, liquidator or the like for the
Debtor of all or any substantial part of the assets, domestic or foreign, of the
Debtor.
<PAGE>
 
     "Financing Statements" means any and all financing statements executed and
      --------------------                                                     
delivered by or on behalf of the Debtor in connection with the perfection of the
Security Interest, together with any amendments thereto and any continuations
thereof.

     "GAAP" means generally accepted accounting principles as set forth in
      ----                                                                
statements from Auditing Standards No. 69 entitled "The Meaning of 'Present
Fairly in Conformance with Generally Accepted Accounting Principles in the
Independent Auditors Reports'" issued by the Auditing Standards Board of the
American Institute of Certified Public Accountants and statements and
pronouncements of the Financial Accounting Standards Board that are applicable
to the circumstances.  Unless otherwise agreed, references to GAAP herein shall
be to GAAP as in effect on the date hereof.

     "Guaranty", "Guaranteed" or to "Guarantee" as applied to any obligation
      --------    ----------         ---------                              
means and includes:

     (a) a guaranty (other than by endorsement of negotiable instruments for
collection in the ordinary course of business), directly or indirectly, in any
manner, of any part or all of such obligation, or
<PAGE>
 
     (b) an agreement, direct or indirect, contingent or otherwise, and whether
or not constituting a guaranty, the practical effect of which is to assure the
payment or performance (or payment of damages in the event of nonperformance) of
any part or all of such obligation whether by:

          (i)   the purchase of securities or obligations,

          (ii)  the purchase, sale or lease (as lessee or lessor) of property or
     the purchase or sale of services primarily for the purpose of enabling the
     obligor with respect to such obligation to make any payment or performance
     (or payment of damages in the event of nonperformance) of or on account of
     any part or all of such obligation, or to assure the owner of such
     obligation against loss,

          (iii) the supplying of funds to or in any other manner investing in
     the obligor with respect to such obligation,

          (iv)  repayment of amounts drawn down by beneficiaries of letters of
     credit, or

          (v)   the supplying of funds to or investing in a Person on account of
     all or any part of such Person's obligation under a Guaranty of any
     obligation or indemnifying or holding harmless, in any way, such Person
     against any part or all of such obligation.

     "Guaranteed Obligations" (a) all Obligations; (b) all other indebtedness
      ----------------------                                                 
and obligations now or hereafter owing by Debtor to Secured Party, whenever and
however incurred or evidenced, whether direct or indirect, absolute or
contingent, or due or to become due (including, but not limited to, any other
loans or advances from time to time extended by Secured Party to Debtor under
any agreement whether or not evidenced by promissory notes or otherwise); and
(c) any and all extensions, renewals, modifications, amendments or substitutions
of the foregoing, including, but not limited to, any and all Guaranteed
Obligations arising under and with respect to the Guaranty.

     "Indebtedness" as applied to a Person means, without duplication, (a) all
      ------------                                                            
items which in accordance with GAAP would be included in determining total
liabilities as shown on the liability side of a balance sheet of such Person as
at the date as of which Indebtedness is to be determined including, without
limitation, all Capitalized Lease Obligations of such Person and all
reimbursement obligations of such Person under letters of credit and acceptances
issued for its account, and (b) all obligations of other Persons which such
Person has Guaranteed.

     "Lien" as applied to the property of any Person means:  () any security
      ----                                                                  
interest, encumbrance, mortgage, deed to secure debt, deed of trust, pledge,
lien, charge or lease constituting a Capitalized Lease Obligation, conditional
sale or other title retention agreement, or other security title or encumbrance
of any kind in respect of any property of such Person, or upon the income or
profits therefrom; () any arrangement, express or implied, under which any
property of such Person is transferred, sequestered or otherwise identified for
the purpose of subjecting the same to the payment of Indebtedness or performance
of any other obligation in priority to the payment of the general, unsecured
<PAGE>
 
creditors of such Person; and () the filing of, or any agreement to give, any
financing statement under the Uniform Commercial Code or its equivalent in any
jurisdiction.

     "Liquidation Agreement" means that certain letter agreement dated the date
      ---------------------                                                    
hereof by and between the Debtor and the Secured Party regarding the sale of
Assets and the settlement of liabilities of Debtor.

     "Material Adverse Effect" on a Person means an event, change or occurrence
      -----------------------                                                  
which, individually or together with any other event, change or occurrence, has
a material adverse impact on (i) the financial position, business, or results of
operations of such Person and its Subsidiaries, taken as a whole, or (ii) the
ability of such Person to perform its obligations under this Agreement or to
consummate the Contribution or the other transactions contemplated by this
Agreement, provided that "Material Adverse Effect" shall not be deemed to
include the impact of (a) changes in laws of general applicability or
interpretations thereof by courts or governmental authorities, (b) changes in
generally accepted accounting principles or regulatory accounting principles,
and (c) actions and omissions of a Person (or any of its Subsidiaries) taken
with the prior informed written consent of the other Person in contemplation of
the transactions contemplated hereby.

     "Note" means that certain Senior Secured Note dated the date hereof in a
      ----                                                                   
principal amount equal to $2,000,000 and executed by Zynaxis in favor of the
Secured Party.

     "Obligations" means, individually and collectively:  (a) all obligations
      -----------                                                            
and indebtedness owing by Zynaxis to the Secured Party and all future advances
made to Zynaxis by the Secured Party, however and whenever created, arising or
evidenced, whether direct or indirect, through assignment from third parties,
whether absolute or contingent, or otherwise, now or hereafter existing, or due
or to become due, including, without limitation, obligations under all
guaranties, letters of credit and overdrafts; and (b) all renewals,
modifications, extensions and supplements to any of the foregoing, including,
but not limited to, any and all Obligations arising under and with respect to
the Note and the Liquidation Agreement.

     "Permitted Liens" means:  (a) Liens securing taxes, assessments and other
      ---------------                                                         
governmental charges or levies not yet due and payable or the claims of, or
obligations owing to, materialmen, mechanics, carriers, warehousemen or
landlords for labor, materials, supplies or rentals incurred in the ordinary
course of business but not yet due and payable; (b) Liens consisting of deposits
or pledges made, in the ordinary course of business, in connection with, or to
secure payment of, obligations under workmen's compensation, unemployment
insurance or similar legislation; (c) Liens consisting of encumbrances in the
nature of zoning restrictions, easements, and rights or restrictions of record
on the use of real property, which in the sole judgment of the Secured Party do
not materially detract from the value of such property or impair the use thereof
in the business of the Debtor; (d) Liens in favor of the Secured Party; and (e)
Liens identified in Schedule 2.(e) hereto.
<PAGE>
 
     "Person" means an individual, corporation, partnership, association, trust
      ------                                                                   
or unincorporated organization, or a government or any agency or political
subdivision thereof.

     "Receivables" means all accounts and any and all rights to the payment of
      -----------                                                             
money or other forms of consideration of any kind (whether classified under the
Uniform Commercial Code as accounts, chattel paper, general intangibles, or
otherwise) for goods sold or leased or for services rendered including, but not
limited to, accounts receivable, proceeds of any letters of credit naming the
Debtor as beneficiary, chattel paper, tax refunds, insurance proceeds, contract
rights, notes, drafts, instruments, documents, acceptances, and all other debts,
obligations and liabilities in whatever form from any Person.

     "Secured Party" has the meaning set forth in the first paragraph hereof.
      -------------                                                          

     "Security Interest" means the Lien of the Secured Party upon, and the
      -----------------                                                   
collateral assignments to the Secured Party of, the Collateral effected hereby
or pursuant to the terms hereof.

     "Subsidiaries" shall mean all those corporations, associations, or other
      ------------                                                           
business entities of which the entity in question either (i) owns or controls
50% or more of the outstanding equity securities either directly or through an
unbroken chain of entities as to each of which 50% or more of the outstanding
equity securities is owned directly or indirectly by its parent (provided, there
shall not be included any such entity the equity securities of which are owned
or controlled in a fiduciary capacity), (ii) in the case of partnerships, serves
as a general partner, (iii) in the case of a limited liability company, serves
as a managing member, or (iv) otherwise has the ability to elect a majority of
the directors, trustees or managing members thereof.

     "Uniform Commercial Code" shall mean the Uniform Commercial Code as in
      -----------------------                                              
effect in the State of Georgia, as the same may be amended from time to time.

     (b) Unless otherwise set forth herein to the contrary, all terms not
otherwise defined herein and which are defined in the Uniform Commercial Code
are used herein with the meanings ascribed to them in the Uniform Commercial
Code.
<PAGE>
 
     IN WITNESS WHEREOF, the Debtor has caused this Security Agreement to be
duly executed and delivered under seal by its duly authorized officers as of the
day first above written.

                            ZYNAXIS VACCINE TECHNOLOGIES, INC.


                            By:    /s/ Martyn Greenacre
                               ---------------------------------
                               Name:  Martyn Greenacre
                                    ----------------------------
                               Title:  Chairman, President & CEO
                                     ---------------------------


                            ATTEST:


                            By:
                               ---------------------------------
                               Name:
                                    ----------------------------
                               Title:
                                     ---------------------------
                               (CORPORATE SEAL)


Agreed and accepted as of the
date first written above.

CYTRX CORPORATION


By:   /s/ Jack J. Luchese
   --------------------------------
  Name:  Jack J. Luchese
       ----------------------------
  Title:  Chairman, President & CEO
        ---------------------------