UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MAY 21 2015 

OFFICE OF CHEMICAL SAFETY 

AND POLLUTION PREVENTION 

MEMORANDUM 

SUBJECT: 

FROM: 

THRU: 

TO: 

BEAD Chemical Profile (BCP) for Registration Review: Alpha-Chlorohydrin (PC 

Code 117101) 

Colwell Cook, Biologist~ Biological Analysis Branch 

Elizabeth Hill, Economist ~--:::?'--->. 

Economic Analysis Brandi 

Biological and Economic Ana ysis Division (7503P) 

Arnet Jones, Chief / 

Biological Analysis Branch { 

Timothy Kiely, Chief /j/) O{l{;kJYlcN~ -{vv !imott\1 }l;'e Lu/ 

Economic Analysis Branch 

Biological and Economic Analysis Division (7503P) 

Matthew Manupella, Chemical Review Manager 

Risk Management and Implementation Branch 2 

Pesticide Re-evaluation Division (7508P) 

PRP date: May 20, 2015 

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SUMMARY 

There is one active registration (EPA Reg.# 42882-2) with the registration name Epibloc®, that 

has the active ingredient alpha-chlorohydrin. This product was initially registered in 1983 and is 

registered for Norway rats in sanitary sewers and inside commercial and industrial facilities. 

This product has not being manufactured nor sold in the United States; consequently, there are 

no usage data for alpha-chlorohydrin available. 

INTRODUCTION 

The Biological and Economic Analysis Division (BEAD) Chemical Profile (BCP) provides an 

overview of the pest management roles and quantitative usage information for active ingredients 

under re-evaluation review. The BCP includes summaries of previous BEAD products and 

available public and/or private use and usage data for alpha-chlorohydrin to describe the role of 

this chemical in pest management. Information provided in this BCP may be used by 

stakeholders (e.g., users and registrants), OPP risk and benefit assessors, OPP risk managers, and 

the general public during the Registration Review process of this pesticide. 

The alpha-chlorohydrin product is a rodenticide bait that can be applied in a sachet ("place 

pack") in sanitary sewers and indoors of industrial and commercial facilities for control of 

Norway rats. 

IDSTORY OF BEAD PRODUCTS 

A search of the BEAD databases for previous analyses for alpha-chlorohydrin indicates that 

there are no records of prior BEAD benefits assessments nor emergency exemption requests for 

this compound. 

BIOLOGICAL ASPECTS RELEVANT ALPHA-CHLOROHYDRIN 

Alpha-chlorohydrin is a rodenticide that causes male infertility in male mammals at low doses. 

At high doses testicular lesions and /or death can occur. S- alpha-chlorohydrin is converted to a 

metabolite that inhibits an essential enzyme in sperm glycolosis, thereby decreasing sperm 

motility and count (USEPA 2006). 

ROLE of ALPHA-CHLOROHYDRIN in RODENT CONTROL 

Since this product is not being marketed in the U.S. it currently plays no role in Norway rat 

control. Theoretically this product would provide a different mode of action to other 

rodenticides. It could play a role in managing populations of Norway rats, although it is unlikely 

to eliminate populations, since the male sterility is reversible once the alpha-chlorohydrin has 

been removed. 

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REFERENCES 

USEP A. 2006. Alpha-Chlorohydrin Pesticide Fact Sheet. Available at: 

http://www.epa.gov/pesticides/chem search/reg actions/registration/fs PC-117101 01-Dec06.pdf Accessed: February 11, 2015. 

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