UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D
.C. 20460 

### MAY 21 2015

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION 

### MEMORANDUM SUBJECT:


### FROM:

THRU:

TO: BEAD Chemical Profile (BCP) for Registration Review: Alpha-Chlorohydrin (PC Code 117101) Colwell Cook,

# Biologist~ Biological Analysis Branch Elizabeth Hill, Economist**~--:::?'--->.** Economic Analysis Brandi Biological andEconomic Ana ysis Division (7503P) ArnetJones, Chief / Biological Analysis Branch { Timothy Kiely, Chief

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# Lu/ Economic Analysis Branch Biological and Economic Analysis Division (7503P) Matthew Manupella, Chemical Review Manager Risk Management and Implementation Branch 2 Pesticide Re-evaluation Division (7508P)


### PRPdate: May 20, 2015

Page 1SUMMARY There is one active registration (EPA Reg.# 42882-2) with the registration name Epibloc®, that has the active ingredient alpha-chlorohydrin. This product was initially registered in 1983 and is registered for Norway rats in sanitary sewers and inside commercial and industrial facilities. This producthas notbeing manufactured nor sold in the United States; consequently, there are no usage data for alpha-chlorohydrin available.
INTRODUCTION TheBiological and Economic Analysis Division (BEAD) Chemical Profile (BCP) provides an overview ofthe pest management roles and quantitative usage information for active ingredients under re-evaluation review. The BCP includes summaries ofprevious BEAD products and available public and/or private use and usage data for alpha-chlorohydrin to describe the role of this chemical in pest management. Information provided inthis BCP may be used by stakeholders (e.g., users and registrants), OPP risk and benefit assessors, OPPrisk managers, and the general public during the Registration Review process ofthis pesticide. The alpha-chlorohydrin product is a rodenticide bait that canbe applied in a sachet ("place pack") in sanitary sewers and indoors ofindustrial and commercial facilities for control of Norway rats.
IDSTORY OFBEAD PRODUCTS A search ofthe BEAD databases for previous analyses for alpha-chlorohydrin indicates that there are no records ofprior BEAD benefits assessments nor emergency exemptionrequests for this compound.
BIOLOGICAL ASPECTS RELEVANT ALPHA-CHLOROHYDRIN Alpha-chlorohydrin is a rodenticide that causes male infertility in male mammals at low doses. Athigh doses testicular lesions and/ordeath can occur. S- alpha-chlorohydrin is converted to a metabolite that inhibits an essential enzyme in sperm glycolosis, thereby decreasing sperm motility and count (USEPA 2006). ROLE ofALPHA-CHLOROHYDRIN in RODENT CONTROL Since this product is not being marketed in the U.S. it currentlyplays no role in Norway rat control. Theoretically this product would provide a different mode ofaction to other rodenticides. Itcould play a role in managing populations ofNorway rats, although it is unlikely to eliminate populations, since the male sterility is reversible once the alpha-chlorohydrinhas beenremoved.
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### REFERENCES USEPA. 

### 2006. Alpha-Chlorohydrin Pesticide Fact Sheet. Available at: http://www.epa.gov/pesticides/chem search/reg actions/registration/fs PC-117101 01-Dec

06.pdf Accessed: February 11, 2015.

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